<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF06</accession>
    <name>A0A7U8TF06_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402901.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424508"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="92" mass="9780" checksum="BDAA16C88A96429C" modified="2021-06-02" version="1">MSAWFNYTATLKILIFSLLAGALLPGLFAVGVRLQAAGDGADATARRRPLLVAVSWAIFALVLAVVIIGVLYIARDFIAHHTGWAFLGATPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF36</accession>
    <name>A0A7U8TF36_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydro_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro_3" evidence="1">
        <location>
            <begin position="50"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="534" mass="57370" checksum="12433C0A18592D22" modified="2021-06-02" version="1">MADADLVMTGTVLTVDDARPTAEAIAVADGRVIAVGDRSEVAGLVGANTRVIDLGAGCVMPGFVEAHGHPLLEAVVLSDRFVDIRPVTMRDADDVVAAIRGEVARRGPAGAYLVGWDPLLQSGLGEPTLTWLDSLAPNGPLVIIHNSGHKAYFNSHAAWLNGLTRDTADPKGAKYGRDGNGELDGTAEEIGAILPLLASVADPSNFGAMLRAECARLNRAGLTTCSEMAFDPGYRPMVEAVRAELTVRLCTYEISNARMCTDATPGQGDDMLRQVGIKIWVDGSPWVGNIDLTFPYLDTPATRAIGVPPGSRGCANYTREQLAEIVGAYFPRGWQIACHVHGDGGVDTILDVYEEALRRNPRDDHRLRLEHVGAIRPDQLRRAAELGVTCSIFVDQIHYWGDVIVDDLFGAQRGSRWMPAGSAVAAGMRISLHNDPPVTPEEPLRNISVAATRVAPSGRVLAPEERLTVEQAIRAQTIDAAWQLFAEDAIGSLQVGKYADMVVLSADPRTVPPEQIADLAVRATFLAGRQVYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF37</accession>
    <name>A0A7U8TF37_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402937.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424523"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030785112" evidence="1">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="29"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="112" mass="12117" checksum="8A3AF97188684AD4" modified="2021-06-02" version="1">MKGTKLAVVVGMTVAAVSLAAPAQADDYDAPFNNTIHRFGIYGPQDYNAWLAKISCERLSRGVDGDAYKSATFLQRNLPRGTTQGQAFQFLGAAIDHYCPEHVGVLQRAGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFA9</accession>
    <name>A0A7U8TFA9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rplL</name>
        <name evidence="7" type="ORF">TBLG_02790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403353.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFA9"/>
    <dbReference type="GeneID" id="45424612"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L12_N" evidence="6">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L12" evidence="5">
        <location>
            <begin position="63"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="130" mass="13440" checksum="EC2EF7E7E50F43ED" modified="2021-06-02" version="1">MAKLSTDELLDAFKEMTLLELSDFVKKFEETFEVTAAAPVAVAAAGAAPAGAAVEAAEEQSEFDVILEAAGDKKIGVIKVVREIVSGLGLKEAKDLVDGAPKPLLEKVAKEAADEAKAKLEAAGATVTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFF7</accession>
    <name>A0A7U8TFF7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpsQ</name>
        <name evidence="8" type="ORF">TBLG_02854</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403596.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFF7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 3 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031076577" description="30S ribosomal protein S17" evidence="7">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="136" mass="14872" checksum="5F7EF044EE366F93" modified="2021-06-02" version="1">MMAEAKTGAKAAPRVAKAAKAAPKKAAPNDAEAIGAANAANVKGPKHTPRTPKPRGRRKTRIGYVVSDKMQKTIVVELEDRMRHPLYGKIIRTTKKVKAHDEDSVAGIGDRVSLMETRPLSATKRWRLVEILEKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFI5</accession>
    <name>A0A7U8TFI5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030691835" evidence="1">
        <location>
            <begin position="41"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="584" mass="57044" checksum="406BFBB133C4D42F" modified="2021-06-02" version="1">MSFVIVARDALAAAAADLAQIGSAVNAGNLAAANPTTAVAAAAADEVSAALAALFGAHAREYQAAAAQAAAYHEQFVHRLSAAATSYAVTEVTIATSLRGALGSAPASVSDGFQAFVYGPIHATGQQWINSPVGEALAPIVNAPTNVLLGRDLIGNGVTGTAAAPNGGPGGLLFGDGGAGYTGGNGGSAGLIGNGGTGGAGFAGGVGGMGGTGGWLMGNGGMGGAGGVGGNGGAGGQALLFGNGGLGGAGGAGGVDGAIGRGGWFIGTGGMATIGGGGNRQSIVIDFVRHGQTPGNAAMLIDTAVPGPGLTALGQQQAQAIANALAAKGPYAGIFDSQLIRTQQTAAPLANLLGMAPQVLPGLNEIHAGIFEDLPQISPAGLLYLVGPIAWTLGFPIVPMLAPGSTDVNGIVFNRAFTGAVQTIYDASLANPVVAADGNITSVAYSSAFTIGVGTMMNVDNPHPLLLLTHPVPNTGAVVVQGNPEGGWTLVSWDGIPVGPASLPTALFVDVRELITAPQYAAYDIWESLFTGDPAAVINAVRDGADEVGAAVVQFPHAVADDVIDATGHPYLSGLPIGLPSLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFJ7</accession>
    <name>A0A7U8TFJ7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403885.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFJ7"/>
    <dbReference type="GeneID" id="45424726"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023921">
        <property type="entry name" value="ADH_Zn_actinomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03989">
        <property type="entry name" value="Rxyl_3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="5">
        <location>
            <begin position="5"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="375" mass="39748" checksum="8DBF5D1504EECDE5" modified="2021-06-02" version="1">MKTKGALIWEFNQPWSVEEIEIGDPRKDEVKIQMEAAGMCRSDHHLVTGDIPMAGFPVLGGHEGAGIVTEVGPGVDDFAPGDHVVLAFIPSCGKCPSCQAGMRNLCDLGAGLLAGESVTDGSFRIQARGQNVYPMTLLGTFSPYMVVHRSSVVKIDPSVPFEVACLVGCGVTTGYGSAVRTADVRPGDDVAIVGLGGVGMAALQGAVSAGARYVFAVEPVEWKRDQALKFGATHVYPDINAALMGIAEVTYGLMAQKVIITVGKLDGADVDSYLTITAKGGTCVLTAIGSLVDTQVTLNLAMLTLLQKNIQGTIFGGGNPHYDIPKLLSMYKAGKLNLDDMVTTAYKLEQINDGYQDMLNGKNIRGVIRYTDDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFK1</accession>
    <name>A0A7U8TFK1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">secY</name>
        <name evidence="13" type="ORF">TBLG_02876</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403723.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFK1"/>
    <dbReference type="GeneID" id="45424697"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="318"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="441" mass="47611" checksum="447C85AA879FEBF2" modified="2021-06-02" version="1">MLSAFISSLRTVDLRRKILFTLGIVILYRVGAALPSPGVNFPNVQQCIKEASAGEAGQIYSLINLFSGGALLKLTVFAVGVMPYITASIIVQLLTVVIPRFEELRKEGQAGQSKMTQYTRYLAIALAILQATSIVALAANGGLLQGCSLDIIADQSIFTLVVIVLVMTGGAALVMWMGELITERGIGNGMSLLIFVGIAARIPAEGQSILESRGGVVFTAVCAAALIIIVGVVFVEQGQRRIPVQYAKRMVGRRMYGGTSTYLPLKVNQAGVIPVIFASSLIYIPHLITQLIRSGSGVVGNSWWDKFVGTYLSDPSNLVYIGIYFGLIIFFTYFYVSITFNPDERADEMKKFGGFIPGIRPGRPTADYLRYVLSRITLPGSIYLGVIAVLPNLFLQIGAGGTVQNLPFGGTAVLIMIGVGLDTVKQIESQLMQRNYEGFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFK6</accession>
    <name>A0A7U8TFK6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031466753" evidence="2">
        <location>
            <begin position="46"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="159" mass="15791" checksum="D76F7B137361B9F2" modified="2021-06-02" version="1">MTASSSHSVEKPCTSDQVASSAPAGFARALGSRSAATPRASSAAAAVSASTSSESEPSSSRAHFTPPLRGHLIAIVSPGLLAPGLLVTITGALEAPGRRGPVAARHPHGSGGMLAGADAGHVRSQCLRIPNGRSHRLCWRSAIEVVSLAAAVTVAVGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFM2</accession>
    <name>A0A7U8TFM2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="56" mass="6242" checksum="A97A33DB80832526" modified="2021-06-02" version="1">MQDAGKTKRAALRCLKRRLARTVFQALRTVHQPSSEHTQPAAACHRSYCSRSCLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFM4</accession>
    <name>A0A7U8TFM4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_02893</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFM4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006226">
        <property type="entry name" value="Mtu_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00028">
        <property type="entry name" value="Mtu_PIN_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="142" mass="15799" checksum="DC4F1405BE9C1DD6" modified="2021-06-02" version="1">MFLLDANVLLAAHRGDHPNHRTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRAEAFAFVEAVTAQPHHLPTNPGPRHLVLLRKLCDEADASGDLIPDAVLAAIAVGHHCAVVSLDRDFARFASVRHIRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFN0</accession>
    <name>A0A7U8TFN0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403880.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFN0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="139" mass="15242" checksum="8291E503C8F07FD0" modified="2021-06-02" version="1">MTQTTQSPALIASQSSWRCVQAHDREGWLALMADDVVIEDPIGKSVTNPDGSGIKGKEAVGAFFDTHIAANRLTVTCEETFPSSSPDEIAHILVLHSEFDGGFTSEVRGVFTYRVNKAGLITNMRGYWNLDMMTFGNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFP9</accession>
    <name>A0A7U8TFP9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TGc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="76"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="242" mass="26710" checksum="8A8336391C5AB071" modified="2021-06-02" version="1">MTLANNGTGMDHFLTPTEYLDAGHPLVRTTAATLIRDAVSDTERVRRIYYYVRDVPYDVLASFRYLAQGHHRASDVIGHGVAFCMGKASSFVALCRAAGVPARIAFQTIDAPDKEFLSPQVRALWGGRTGRPFPWHSLGEAYLGRRWVKLDATIDAPTAARLGKPYRQEFDGATPIPTVEGTILRENGSYADYPSAVAQWYERIAQSVLKALQSTEVHALVAPDEELWTGPPVELADATHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFT1</accession>
    <name>A0A7U8TFT1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">rRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03034</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404610.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFT1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="132"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="288" mass="30701" checksum="11931734A6E26F29" modified="2021-06-02" version="1">MTEGRCAQHPDGLDVQDVCDPDDPRLDDFRDLNSIDRRPDLPTGKALVIAEGVLVVQRMLASRFTPLALFGTDRRLAELKDDLAGVGAPYYRASADVMARVIGFHLNRGVLAAARRVPEPSVAQVVAGARTVAVLEGVNDHENLGSIFRNAAGLSVDAVVFGTGCADPLYRRAVRVSMGHALLVPYARAADWPTELMTLKESGFRLLAMTPHGNACKLPEAIAAVSHERIALLVGAEGPGLTAAALRISDVRVRIPMSRGTDSLNVATAAALAFYERTRSGHHIGPGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFT5</accession>
    <name>A0A7U8TFT5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, luxR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="814"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="882" mass="94570" checksum="694141F0F10BD434" modified="2021-06-02" version="1">MRALLAQNRLVTLCGTGGVGKTRLAIQIASASELRDGLCFVDLAPITESGIVAATAARAVGLPDQPGRSTMDSLRRFIGNRRMLMVLDNCEHLLDACAALVVELLGACPELTILATSREPIGMAGEITWRVPSMSITDEAVELFADRASRVQPGFTIANHNAAAVGEICRRLDGIPLAIEFAAARVRSMSPLEIADGLDDCFRLLAGGVRGAVQRQQTLRASIDWSHALLTETEQILFRRLAPFVGGFDLAAVRAVAAGSDLDPFSVLDQLTLLVDKSLVVADDCQGRTRYRLLETVRRYALEKLGDSGEADVHARHRDYYTALAASLNTPADNDHQRLVARAETEIDNLRAAFAWSRENGHITEALQLASSLQPIWFGRAHLREGLSWFNSILEDQRFHRLAVSTAVRARALADKAMLSTWLATSPVGATDIIAPAQQALAMAREVGDPAALVRALTACGCSSGYNAEAAAPYFAEATDLARAIDDKWTLCQILYWRGVGTCISGDPNALRAAAEECRDLADTIGDRFVSRHCSLWLSLAQMWAGNLTEALELSREITAEAEASNDVPTKVLGLYTQAQVLAYCGASAAHAIAGACIAAATELGGVYQGIGYAAMTYAALAAGDVTAALEASDAARPILRAQPDQVTMHQVLMAQLALAGGDAIAARQFANDAVDATNGWHRMVALTIRARVATARGEPELARDDAHAALACGAELHIYQGMPDAMELLAGLAGEVGSHSEGVRLLGAAAALRQQTRQVRFKIWDAGYQASVTALREAMGDEDFDRAWAEGAALSTDEAIAYAQRGRGERKRPARGWGSLTPTERDVVRLVSERLSNKDIAKRLFVSPRTVQTHLTHVYAKLGLASRVQLVDEAARRGSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFU3</accession>
    <name>A0A7U8TFU3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, luxR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="211" mass="23257" checksum="69AA25E6746FBCA7" modified="2021-06-02" version="1">MPSRATVQEFSDSYPFCHNGFRPIMMPKIVSVQHSTRRHLTSFVGRKAELNDVRRLLSDKRLVTLTGPDGMGKSRLALQIGAQIAHEFTYGRWDCDLATVTDRDCVSISMLNALGLPVQPGLSAIDTLVGVINDARVLLVLDHCEHLLDACAAIIDSLLRSCPRLTILTTSTEAIGLAGELTWRVPPLSLTNDAIELFVDRARRVRSGFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFW4</accession>
    <name>A0A7U8TFW4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404756.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFW4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="166" mass="18081" checksum="98093E7F6085E54B" modified="2021-06-02" version="1">MSGYSAPRRISDADDVTSFSSGEPSLDDYLRKRALANHVQGGSRCFVTCRDGRVVGFYALASGSVAHADAPGRVRRNMPDPVPVILLSRLAVDRKEQGRGLGSHLLRDAIGRCVQAADSIGLRAILVHALHDEARAFYVHFDFEISPTDPLHLMLLMKDARALIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFX2</accession>
    <name>A0A7U8TFX2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid carrier protein or keto acyl-CoA thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFX2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="287"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="412" mass="43875" checksum="085E9F4D807EE94B" modified="2021-06-02" version="1">MDDGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAKVDAADLAAAGVVHVANAFGEMFARQGHLGAMPATVCDDLWDTPATRHEAACASGSVATLAAMADLRSGAYRVALVVGLELEKTVPGDTAAEHLSAAAWTGHEGAEARYLWPSMFAQVADEYDRRYGLDDTHLRAIAQLNFANARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLVSDAYLRDHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVRATVLDALRRARVTLDDLDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIENGEIEIGGRLPINPSGGLIGGGHPVGASGVRMLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTATTVSFVVSTTRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG05</accession>
    <name>A0A7U8TG05_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="160" mass="17321" checksum="2B6EC9285EFE4BDF" modified="2021-06-02" version="1">MGLLGFGGAAAEAAQVATHHTTVLLDHHAGACEAVARAAEKAAEEVAAIKMRLQVIRDAAREHHLTIAYATGTALPPPDLSSYSPADQQAILNTAIRRASNVCWPTPRPPMRIWPRRFDAPPGTCRASRSMPNSAMRHPQCRRCRRRTATLRRSSGGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG43</accession>
    <name>A0A7U8TG43_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyketide synthase pks16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405202.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG43"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="2">
        <location>
            <begin position="444"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="544" mass="58467" checksum="B91D412C110EF246" modified="2021-06-02" version="1">MSRFTEKMFHNARTATTGMVTGEPHMPVRHTWGEVHERARCIAGGLAAAGVGLGDVVGVLAGFPVEIAPTAQALWMRGASLTMLHQPTPRTDLAVWAEDTMTVIGMIEAKAVIVSEPFLVAIPILEQKGMQVLTVADLLASDPIGPIEVGEDDLALMQLTSGSTGSPKAVQITHRNIYSNAEAMFVGAQYDVDKDVMVSWLPCFHDMGMVGFLTIPMFFGAELVKVTPMDFLRDTLLWAKLIDKYQGTMTAAPNFAYALLAKRLRRQAKPGDFDLSTLRFALSGAEPVEPADVEDLLDAGKPFGLRPSAILPAYGMAETTLAVSFSECNAGLVVDEVDADLLAALRRAVPATKGNTRRLATLGPLLQDLEARIIDEQGDVMPARGVGVIELRGESLTPGYLTMGGFIPAQDEHGWYDTGDLGYLTEEGHVVVCGRVKDVIIMAGRNIYPTDIERAAGRVDGVRPGCAVAVRLDAGHSRESFAVAVESNAFEDPAEVRRIEHQVAHEVVAEVDVRPRNVVVLGPGTIPKTPSGKLRRANSVTLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG45</accession>
    <name>A0A7U8TG45_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ppx-GppA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405299.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG45"/>
    <dbReference type="GeneID" id="45424998"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="319" mass="33664" checksum="8BF72E61F9F1E4BE" modified="2021-06-02" version="1">MALTRVAAIDCGTNSIRLLIADVGAGLARGELHDVHRETRIVRLGQGVDATGRFAPEAIARTRTALTDYAELLTFHHAERVRMVATSAARDVVNRDVFFAMTADVLGAALPGSAAEVITGAEEAELSFRGAVGELGSAGAPFVVVDLGGGSTEIVLGEHEVVASYSADIGCVRLTERCLHSDPPTLQEVSTARRLVRERLEPALRTVPLELARTWVGLAGTMTTLSALAQSMTAYDAAAIHLSRVPGADLLEVCQRLIGMTRKQRAALAPMHPGRADVIGGGAIVVEELARELRERAGIDQLTVSEHDILDGIALSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG79</accession>
    <name>A0A7U8TG79_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG79"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014417">
        <property type="entry name" value="Integrase_predicted"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004338">
        <property type="entry name" value="Integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="104" mass="11830" checksum="7900BAC3B0AB6C29" modified="2021-06-02" version="1">MTGKGIVESTTKTKRDRHVPVPEPVWRRLHAELPTDPNALVFPGRKGGFLPLGEYRWAFDNAGDQVGIEGWYRTVWGTPRPRWRSAQALTSRSCNGSLDTQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG91</accession>
    <name>A0A7U8TG91_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="135" mass="10823" checksum="8D8628B03371D9D1" modified="2021-06-02" version="1">MRGLFGNGGAGGGGGKGGNGAGGGLGGGSFGLPGLNGSGGDGGDGGNGAPGGVLYGNGGAGGQGSSGGIGGPGATGGAGGKGGDGGDAQLIGDGGNGGNGGAGGTGGTPGPGGPGGSGGLGGLLFGQTGTAGVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG92</accession>
    <name>A0A7U8TG92_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hemolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0073 (Hly-III) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901993.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG92"/>
    <dbReference type="GeneID" id="45425058"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019835">
        <property type="term" value="P:cytolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004254">
        <property type="entry name" value="AdipoR/HlyIII-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005744">
        <property type="entry name" value="Hy-lIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20855">
        <property type="entry name" value="PTHR20855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03006">
        <property type="entry name" value="HlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01065">
        <property type="entry name" value="hlyIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="242" mass="26034" checksum="BBC1DE12CF8D3500" modified="2021-06-02" version="1">MSGQADTATTAEARTPAHAAHHLVEGVARVLTKPRFRGWIHVYSAGTAVLAGASLVAVSWAVGSAKAGLTTLAYTAATITMFTVSATYHRVNWKSATARNWMKRADHSMIFVFIAGSYTPFALLALPAHDGRVVLSIVWGGAIAGILLKMCWPAAPRSVGVPLYLLLGWVAVWYTATILHNAGVTALVLLFVGGALYSIGGILYAVRWPDPWPTTFGYHEFFHACTAVAAICHYIAMWFVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG96</accession>
    <name>A0A7U8TG96_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="3">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="3">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xseB</name>
        <name evidence="4" type="ORF">TBLG_03280</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="3"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405844.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG96"/>
    <dbReference type="GeneID" id="45425081"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="85" mass="9322" checksum="ACD4756808DA79A8" modified="2021-06-02" version="1">MVCDPNGDDTGRTHATVPVSQLGYEACRDELMEVVRLLEQGGLDLDASLRLWERGEQLAKRCEEHLAGARQRVSDVLAGDEAQNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGE0</accession>
    <name>A0A7U8TGE0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GTP-binding protein TypA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="2">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="469" mass="50046" checksum="D1B0DF02EB460750" modified="2021-06-02" version="1" fragment="single">MPFRNVAIVAHVDHGKTTLVDAMLRQSGALRERGELQERVMDTGDLEREKGITILAKNTAVHRHHPDGTVTVINVIDTPGHADFGGEVERGLSMVDGVLLLVDASEGPLPQTRFVLRKALAAHLPVILVVNKTDRPDARIAEVVDASHDLLLDVASDLDDEAAAAAEHALGLPTLYASGRAGVASTTAPPDGQVPDGTNLDPLFEVLEKHVPPPKGEPDAPLQALVTNLDASTFLGRLALIRIYNGRIRKGQQVAWIRQVDGQQTVTTAKITELLATEGVERKPTDAAVAGDIVAVAGLPEIMIGDTLAASANPVALPRITVDEPAISVTIGTNTSPLAGKVGGHKLTARMVRSRLDAELVGNVSIRVVDIGAPDAWEVQGRGELALAVLVEQMRREGFELTVGKPQVVTKTIDGTLHEPFESMTVDCPEEYIGAVTQLMAARKGRMVEMANHTTGWVRMDFVVPSPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGH2</accession>
    <name>A0A7U8TGH2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA-3-methyladenine glycosylase I tagA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03386</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406244.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGH2"/>
    <dbReference type="GeneID" id="45425180"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005019">
        <property type="entry name" value="Adenine_glyco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004597">
        <property type="entry name" value="Tag"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03352">
        <property type="entry name" value="Adenine_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00624">
        <property type="entry name" value="tag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="204" mass="23005" checksum="F20BB256292432FD" modified="2021-06-02" version="1">MSGDGLVRCPWAEVRPGPDAQLYRDYHDNEWGRPLYGRVALFERMSLEAFQSGLSWLIILRKRENFRRAFSGFDIDKIARYTDTDVRRLLADDGIVRNRAKIEATIANARAAADLGSSEDLSELLWSFAPPPRPRPVDGSEIPSVSTESKAMSRELKRRGFRFVGPTTAYALMQATGMVDDHIQACWVPTERPFDQPGCPMAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGH4</accession>
    <name>A0A7U8TGH4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03388</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898773.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGH4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009250">
        <property type="term" value="P:glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011875">
        <property type="entry name" value="M1P_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02149">
        <property type="entry name" value="glgA_Coryne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="194"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="387" mass="41533" checksum="BC4C4B66980BAAFF" modified="2021-06-02" version="1">MRVAMLTREYPPEVYGGAGVHVTELVAYLRRLCAVDVHCMGAPRPGAFAYRPDPRLGSANAALSTLSADLVMANAASAATVVHSHTWYTALAGHLAAILYDIPHVLTAHSLEPLRPWKKEQLGGGYQVSTWVEQTAVLAANAVIAVSSAMRNDMLRVYPSLDPNLVHVIRNGIDTETWYPAGPARTGSVLAELGVDPNRPMAVFVGRITRQKGVVHLVTAAHRFRSDVQLVLCAGAADTPEVADEVRVAVAELARNRTGVFWIQDRLTIGQLREILSAATVFVCPSVYEPLGIVNLEAMACATAVVASDVGGIPEVVADGITGSLVHYDADDATGYQARLAEAVNALVADPATAERYGHAGRQRCIQEFSWAYIAEQTLDIYRKVCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGH8</accession>
    <name>A0A7U8TGH8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001827">
        <property type="entry name" value="Homeobox_Antennapedia_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031304">
        <property type="entry name" value="SLT_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13406">
        <property type="entry name" value="SLT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00032">
        <property type="entry name" value="ANTENNAPEDIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="SLT_2" evidence="4">
        <location>
            <begin position="194"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="411" mass="41387" checksum="BE601AC4EA1A3500" modified="2021-06-02" version="1">MHIGGRWGARPAVAAVRRGACRLTRAPAFGVAAIAPLVFASAVGGAAPVFPGRTAPVHAVITPVAAVAASGIDLSGPVVIAMKRPPTSFRVAVATISAPPPPMIVNSPGALGIPAMALSAYRNAELKMAAAAPGCGVSWNLLAGIGRIESMHANGGATDARGTAIQPIYGPTLDGTLPGNEIIIQSSVGNRVTYARAMGPMQFLPGTWARYATDGDDDGVADPQNLFDSTLAAARYLCSGGLNLRDPAQVMAALLRYNNSMPYAQNVLGWAAGYATGVFPVDLPPITGPPPPLGDAHLENPEGLGPGLPINVNGLTADGPMAHLPLIDLTPRQAALNPPPMFPWMAPDPSAPMPGCTLICIGSHGPPVGAPPFPPTAPPPPFLPAAPPPPDPLAGPPGDAGLAPPAPAPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGI3</accession>
    <name>A0A7U8TGI3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar-transport ATP-binding protein ABC transporter sugC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03415</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406299.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGI3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008643">
        <property type="term" value="P:carbohydrate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03301">
        <property type="entry name" value="ABC_MalK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015855">
        <property type="entry name" value="ABC_transpr_MalK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040582">
        <property type="entry name" value="OB_MalK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17912">
        <property type="entry name" value="OB_MalK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="393" mass="42915" checksum="0152AA1F79F5A9D5" modified="2021-06-02" version="1">MAEIVLDHVNKSYPDGHTAVRDLNLTIADGEFLILVGPSGCGKTTTLNMIAGLEDISSGELRIAGERVNEKAPKDRDIAMVFQSYALYPHMTVRQNIAFPLTLAKMRKADIAQKVSETAKILDLTNLLDRKPSQLSGGQRQRVAMGRAIVRHPKAFLMDEPLSNLDAKLRVQMRGEIAQLQRRLGTTTVYVTHDQTEAMTLGDRVVVMYGGIAQQIGTPEELYERPANLFVAGFIGSPAMNFFPARLTAIGLTLPFGEVTLAPEVQGVIAAHPKPENVIVGVRPEHIQDAALIDAYQRIRALTFQVKVNLVESLGADKYLYFTTESPAVHSVQLDELAEVEGESALHENQFVARVPAESKVAIGQSVELAFDTARLAVFDADSGANLTIPHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGJ4</accession>
    <name>A0A7U8TGJ4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase_H_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019993">
        <property type="entry name" value="RecB_nuclease_TM0106_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038720">
        <property type="entry name" value="YprB_RNase_H-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13482">
        <property type="entry name" value="RNase_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03491">
        <property type="entry name" value="TIGR03491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_H_2" evidence="1">
        <location>
            <begin position="320"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="787" mass="85727" checksum="B9C69E7F3FFE1A1F" modified="2021-06-02" version="1">MSHRGVAAVFVTGDSIVYSASDLAAAARCQYALLREFDAKLGRGPAVAVDDELMARAAVLGSAHEGRRLDQLRHEFGDAVAIIGRPAYTPAGLAAAADATRRAIANHAPVVYQAAMFDGRFVGFADFLIRDGHRYRVADTKLARSPTVTALLQLAAYADALVHSGVPVAADAELELGDGTIVRYRVGELIPVYRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQCTERLRASDDLLLVGGMRVRQRDKLLEAGITTIAELADHTAPVPGLTTNALGKLTAQAKLQIRQRDTGAPQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQWGLEYLFGVLEAGRAGVFRPLWAHDRTAERQALTDFLAIVARRRRRHPNMHIYHYAPYEKTALLRLVGRYGIGEDDVDDLLRNGVLVDLYPLVRKSIRVGTDSFSLKALEPLYLGTQPRSGDVTTAADSINSYARYCELRAAGRIDEAATVLKEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQPVPDADPIDDGDSLASVLSKFTGDAAAGERTPEQTAVALLAAARGYHRREDKPFWWAHFDRLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTGELARGDLNGNVFALYEPPAPPGMTDNPDRRAAGPAAVVETDDPTVPTEVVIVERTRSDGNTFQQLPFALAPGPPVPTTALRESIESTAAAVASGSPQLPSTALMDVLLRRPPRTRSGAALPRSSDPVTDIAAAALDLDSSYLAVHGPSGDRARRTTAPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGK4</accession>
    <name>A0A7U8TGK4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transmembrane ATP-binding protein ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03446</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="537"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="575"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="615"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="759"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="26"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="148"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="226"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="266"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="792" mass="85883" checksum="1BE418B77412DE39" modified="2021-06-02" version="1">MITPNAPRLELRAAGRTWHAVAGREWSIGRASEADIRLDNPRVSRQHAVLEATPEGWVLVNLSTNGTFVDGQRVERLTVRQPITIFLGSASSGQRVQLYPVAQSPTPTPASHPPAPPRPATPKPAQRQGETTVARPPTAFHAIDQLVVTIGRAPENTVVLNDLLVSRRHAILRRTGNRWELSDNASANGTYVNGHRISRAVIGPTDIVGIGHQLLHLSGDRLVEYVDTGDISYQASNLRVVTNKGRVLLADVSFVLPQRSLLAVVGPSGAGKSTLLGALTGFRPAGNGTVRYDERDLYDNYAELRHRIGFVPQDDILHTPLTVRRALNYAARLRFPQDVSVDERNQRIEEVLVELGLSTQADQRIDSLSGGQRKRTSVALELLTKPSLLFLDEPTSGLDPGYEKSVMQTLRKLADDGRSVVVVTHNIAHLNMCDRLLILAPGGRLAYFGPPQQALGYFNCTDFADLFTLLEHDTSTDWTGRFNASPLREALIGHPAMRPARPAAARHARPVAQQSAFAQFAILCRRYLAVIAADRQYAVFLLVLPLLLSLFAHAVPGQAGLSLAKAIELKSTQPSQLLVLLIIGGALMGCAASIREIVKERAIYRREHGIGLSRGAYLASKLVVLTALTSLQALILGFLGVALLPPPDQSVILPWPSVEVAVAVVAVTVVSMMIGLLISAMIGNADRGMPLLVLVVMAQLVLCGGMFGVSGRPPLEQLSWLSPSRWAYAMAAATVDLNDLRRTAGGDQDPLWDYNVGSWLMAAGACAVQALVLVILIALQLKRIEPQRKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGK6</accession>
    <name>A0A7U8TGK6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Drugs-transport transmembrane ATP-binding protein ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406574.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGK6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="335"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="582" mass="62116" checksum="B9002E187776691F" modified="2021-06-02" version="1">MLLALLRQHIRPYRRLVAMLMMLQLVSTLASLYLPTVNAAIVDDGVAKGDTATIVRLGAVMLGVTGLQVLCAIGAVYLGSRTGAGFGRDLRSAMFEHIITFSERETARFGAPTLLTRSTNDVRQILFLVQMTATVLVTAPIMCVGGIIMAIHQEAALTWLLLVSVPILAVANYWIISHMLPLFRRMQSLIDGINRVMRDQLSGVRVVRAFTREGYERDKFAQANTALSNAALSAGNWQALMLPVTTLTINASSVALIWFGGLRIDSGQMQVGSLIAFLSYFAQILMAVLMATMTLAVLPRASVCAERITEVLSTPAALGNPDNPKFPTDGVTGVVRLAGATFTYPGADCPVLQDISLTARPGTTTAIVGSTGSGKSTLVSLICRLYDVTAGAVLVDGIDVREYHTERLWSAIGLVPQRSYLFSGTVADNLRYGGGPDQVVTEQEMWEALRVAAADGFVQTDGLQTRVAQGGVNFSGGQRQRLAIARAVIRRPAIYVFDDAFSALDVHTDAKVHASLRQVSGDATIIVVTQRISNAAQADQVIVVDNGKIVGTGTHETLLADCPTYAEFAASQSLSATVGGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGL5</accession>
    <name>A0A7U8TGL5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Sulfate adenylyltransferase subunit 1</fullName>
                <ecNumber evidence="12">2.7.7.4</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">ATP-sulfurylase large subunit</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="12">Sulfate adenylate transferase</fullName>
                <shortName evidence="12">SAT</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Adenylyl-sulfate kinase</fullName>
                <ecNumber evidence="13">2.7.1.25</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="13">APS kinase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="13">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="13">Adenosine-5'-phosphosulfate kinase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysC</name>
        <name evidence="12" type="synonym">cysN</name>
        <name evidence="16" type="ORF">TBLG_03467</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">APS kinase catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Catalyzes the synthesis of activated sulfate.</text>
    </comment>
    <comment type="function">
        <text evidence="12">With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 13">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="12">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="13">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="12"/>
    <dbReference type="EC" id="2.7.1.25" evidence="13"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406621.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGL5"/>
    <dbReference type="GeneID" id="45425258"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00062">
        <property type="entry name" value="Sulf_adenylyltr_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="578"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="524"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="11"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="450"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFD12883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="614" mass="67839" checksum="2C3709C8B91867C4" modified="2021-06-02" version="1">MTTLLRLATAGSVDDGKSTLIGRLLYDSKAVMEDQWASVEQTSKDRGHDYTDLALVTDGLRAEREQGITIDVAYRYFATPKRKFIIADTPGHIQYTRNMVTGASTAQLVIVLVDARHGLLEQSRRHAFLASLLGIRHLVLAVNKMDLLGWDQEKFDAIRDEFHAFAARLDVQDVTSIPISALHGDNVVTKSDQTPWYEGPSLLSHLEDVYIAGDRNMVDVRFPVQYVIRPHTLEHQDHRSYAGTVASGVMRSGDEVVVLPIGKTTRITAIDGPNGPVAEAFPPMAVSVRLADDIDISRGDMIARTHNQPRITQEFDATVCWMADNAVLEPGRDYVVKHTTRTVRARIAGLDYRLDVNTLHRDKTATALKLNELGRVSLRTQVPLLLDEYTRNASTGSFILIDPDTNGTVAAGMVLRDVSARTPSPNTVRHRSLVTAQDRPPRGKTVWFTGLSGSGKSSVAMLVERKLLEKGISAYVLDGDNLRHGLNADLGFSMADRAENLRRLSHVATLLADCGHLVLVPAISPLAEHRALARKVHADAGIDFFEVFCDTPLQDCERRDPKGLYAKARAGEITHFTGIDSPYQRPKNPDLRLTPDRSIDEQAQEVIDLLESSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGR1</accession>
    <name>A0A7U8TGR1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-[acyl-carrier protein] reductase fabG2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406963.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGR1"/>
    <dbReference type="GeneID" id="45425329"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="247" mass="25871" checksum="76CA07892E7BBA73" modified="2021-06-02" version="1">MASLLNARTAVITGGAQGLGLAIGQRFVAEGARVVLGDVNLEATEVAAKRLGGDDVALAVRCDVTQADDVDILIRTAVERFGGLDVMVNNAGITRDATMRTMTEEQFDQVIAVHLKGTWNGTRLAAAIMRERKRGAIVNMSSVSGKVGMVGQTNYSAAKAGIVGMTKAAAKELAHLGIRVNAIAPGLIRSAMTEAMPQRIWDQKLAEVPMGRAGEPSEVASVAVFLASDLSSYMTGTVLDVTGGRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGR2</accession>
    <name>A0A7U8TGR2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898835.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425330"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="109" mass="12054" checksum="B26551789FC2E72E" modified="2021-06-02" version="1">MTPRSLPRYGNSSRRKSFPMHRPSNVATATRKKSSIGWVLLACSVAGCKGIDTTEFILGRAGAFELAVRAAQHRHRYLTMVNVGRAPPRRCRTVCMAATDTPRNIRLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGU1</accession>
    <name>A0A7U8TGU1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407257.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGU1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="492" mass="55252" checksum="9E8FCDAEFF70EABC" modified="2021-06-02" version="1">MMPDYHALIVGAGFSGIGAAIKLDRAGFSDYLVVEAGDGVGGTWHWNTYPGIAVDIPSFSYQFSFEQSRHWSRTYAPGHELKAYAEHCVDKYGIRSRIRLNTKVLAAEFDDEHSLWRVQTDPGGEITARFLISACGILTVPKLPDIDGVDSFEGVTMHTARWDHTQDLTGKRVGIIGTGASAVQVIPEMAPIVSHLTVFQRTPIWCFPKFDVPLPTAVRWAMRIPGGKAVHRLLSQAFVEATFPIAAHYFAVFPLAKHMESAGRRYLRQQVHDPVVREQLTPRYAVGCKRPGFHNTYLSTFNRDNVRLVTEPIDKITPTAVATTDGASHEIDVLVLATGFKVLDTDSIPTYAVTGTGGASLSRFWDEHRLQAYEGVSVPGYPNFFTVFGPYGYVGSSYFALIETQAHHIIRCLKRARRTGATRIEVTEEANARYFAEVMRRRHRQVFWQDSCRLANSYYFDKNGDVPLRPTTTVEAYWRSRRFDLGDYRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGV7</accession>
    <name>A0A7U8TGV7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative gluconeogenesis factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for morphogenesis under gluconeogenic growth conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the gluconeogenesis factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407352.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGV7"/>
    <dbReference type="GeneID" id="45425400"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00973">
        <property type="entry name" value="Gluconeogen_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010119">
        <property type="entry name" value="Gluconeogen_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30135">
        <property type="entry name" value="PTHR30135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01826">
        <property type="entry name" value="CofD_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD13026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="342" mass="35823" checksum="D38C002F8C0BA16D" modified="2021-06-02" version="1">MTDGIVALGGGHGLYATLSAARRLTPYVTAVVTVADDGGSSGRLRSELDVVPPGDLRMALAALASDSPHGRLWATILQHRFGGSGALAGHPIGNLMLAGLSEVLADPVAALDELGRILGVKGRVLPMCPVALQIEADVSGLEADPRMFRLIRGQVAIATTPGKVRRVRLLPTDPPATRQAVDAIMAADLVVLGPGSWFTSVIPHVLVPGLAAALRATSARRALVLNLVAEPGETAGFSVERHLHVLAQHAPGFTVHDIIIDAERVPSEREREQLRRTATMLQAEVHFADVARPGTPLHDPGKLAAVLDGVCARDVGASEPPVAATQEIPIDGGRPRGDDAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGY6</accession>
    <name>A0A7U8TGY6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-ser_dehydrat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGY6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-ser_dehydrat" evidence="1">
        <location>
            <begin position="19"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="133" mass="14330" checksum="DC6852AA33DB4ABA" modified="2021-06-02" version="1">MLGDAQQLELGRCAPADIALTVAATVVSRQDCRSGLRRIVLDCGSKILGSDRPAWATGFGRLIDHADARIAALSEHHATVVWPDDAPLPPVGTRLRVIPNHVCLTTNLVDDVAVVRDATLIDRWKVAARGKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH98</accession>
    <name>A0A7U8TH98_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5 7">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsL</name>
        <name evidence="9" type="ORF">TBLG_02825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1 5 7">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5 7">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403453.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH98"/>
    <dbReference type="GeneID" id="45424644"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="124" mass="13849" checksum="2B441B040CEF20CD" modified="2021-06-02" version="1">MPTIQQLVRKGRRDKISKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVKLTSQVEVTAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYKIIRGSLDTQGVKNRKQARSRYGAKKEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THE4</accession>
    <name>A0A7U8THE4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycine betaine transport membrane protein betP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03074</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BCCT transporter (TC 2.A.15) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071705">
        <property type="term" value="P:nitrogen compound transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018093">
        <property type="entry name" value="BCCT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000060">
        <property type="entry name" value="BCCT_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30047">
        <property type="entry name" value="PTHR30047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02028">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00842">
        <property type="entry name" value="bcct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01303">
        <property type="entry name" value="BCCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="593" mass="63840" checksum="7BA2433A55C1DD8B" modified="2021-06-02" version="1">MSAKERGDQNAVVDALRSIQPAVFIPASVVIVAMIVVSVVYSSVAENAFVRLNSAITGGVGWWYILVATGFVVFALYCGISRIGTIRLGRDDELPEFSFWAWLAMLFSAGMGIGLVFYGVAEPLSHYLRPPRSRGVPALTDAAANQAMALTVFHWGLHAWAIYVVVGLGMAYMTYQRGRPLSVRWLLEPVVGRGRVEGALGHAVDVIAIVGTLFGVATSLGFGITQIASGLEYLGWIRVDNWWMVGMIAAITATATASVVSGVSKGLKWLSNINMALAAALALFVLLLGPTLFLLQSWVQNLGGYVQSLPQFMLRTAPFSHDGWLGDWTIFYWGWWISWAPFVGMFIARISRGRTIREFIGAVLLVPTVIASLWFTIFGDSALLRQRNNGDMLVNGAVDTNTSLFRLLDGLPIGAITSVLAVLVIVFFFVTSSDSGSLVIDILSAGGELDPPKLTRVYWAVLEGVAAAVLLLIGGAGSLTALRTAAIATALPFSIVMVVACYAMTKAFHFDLAATPRLLHVTVPDVVAAGNRRRHDISATLSGLIAVRDVDSGTYIVHPDTGALTVTAPPDPLDDHVFESDRHVTRRNTTSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THH0</accession>
    <name>A0A7U8THH0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404898.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THH0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="73" mass="7918" checksum="9055EA99193F5435" modified="2021-06-02" version="1">MKTLYLRNVPDDVVERLERLAELAKTSVSAVAVRELTEASRRADNPALLGDLPDIGIDTTELIGGIDAERAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THJ4</accession>
    <name>A0A7U8THJ4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adhesion component transport ATP-binding protein ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900248.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THJ4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="248" mass="27373" checksum="711E0BBC872BB81A" modified="2021-06-02" version="1">MNRQPIVQLSNLSWTFREGETRRQVLDHITFDFEPGEFVALLGQSGSGKSTLLNLISGIEKPTTGDVTINGFAITQKTERDRTLFRRDQIGIVFQFFNLIPTLTVLENITLPQELAGVSQRKAAVVARDLLEKVGMADRERTFPDKLSGGEQQRVAISRALAHNPMLVLADEPTGNLDSDTGDKVLDVLLDLTRQAGKTLIMATHSPSMTQHADRVVNLQGGRLIPAVNRENQTDQPASTILLPTSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THQ9</accession>
    <name>A0A7U8THQ9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphate starvation-inducible protein phoH2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03269</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405802.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THQ9"/>
    <dbReference type="GeneID" id="45425069"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="7">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="433" mass="46914" checksum="191E65BD34073C8C" modified="2021-06-02" version="1">MTDTRTYVLDTSVLLSDPWACSRFAEHDVVVPLVVISELEAKRHHHELGWFARQALRLFDDLRLEHGRLDQPIPVGTQGGTLHVELNHTDPAVLPAGFRTDSNDSRILSCAANLAAEGKRVTLVSKDIPLRVKAAAVGLAADEYHAQDVVVSGWSGMHELETASADIDALFADGEIDLVEARDLPCHTGIRLLGGGSHALGRVNAHKRVQLVRGDREAFGLRGRSAEQRVALDLLLDESVGIVSLGGKAGTGKSALALCAGLEAVLERRTHRKVVVFRPLYAVGGQELGYLPGSESEKMGPWAQAVFDTLEGLASPAVLEEVLSRGMLEVLPLTHIRGRSLHDSFVIVDEAQSLERNVLLTVLSRLGTGSRVVLTHDIAQRDNLRVGRHDGVAAVIEKLKGHPLFAHITLLRSERSPIAALVTEMLEEITGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THW5</accession>
    <name>A0A7U8THW5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane transporter mmpL10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898761.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031349608" evidence="8">
        <location>
            <begin position="23"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="829"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="860"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="903"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="930"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="9">
        <location>
            <begin position="30"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="9">
        <location>
            <begin position="635"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1002" mass="106415" checksum="5B49B70AF2076AD8" modified="2021-06-02" version="1">MVGCWVALALVLPMAVPSLAEMAQRHPVAVLPADAPSSVAVRQMAEAFHESGSENILVVLLTDEKGLGAADENVYHTLVDRLRNDAKDVVMLQDFLTTPPLREVLGSKDGKAWILPIGLAGDLGTPKSYHAYTDVERIVKRTVAGTTLTANVTGPAATVADLTDAGARDRASIELAIAVMLLVILMVIYRNPVTMLLPLVTIGASLMTAQALVAGVSLVGGLAVSNQAIVLLSAMIAGAGTDYAVFLISRYHEYVRLGEHPERAVQRAMMSVGKVIAASAATVGITFLGMRFAKLGVFSTVGPALAIGIAVSFLAAVTLLPAILVLASPRGWVAPRGERMATFWRRAGTRIVRRPKAYLGASLIGLVALASCASLAHFNYDDRKQLPPSDPSSVGYAAMEHHFSVNQTIPEYLIIHSAHDLRTPRGLADLEQLAQRVSQIPGVAMVRGVTRPNGETLEQARATYQAGQVGNRLGGASRMIDERTGDLNRLASGANLLADNLGDVRGQVSRAVAGVRSLVDALAYIQNQFGGNKTFNEIDNAARLVSNIHALGDALQVNFDGIANSFDWLDSVVAALDTSPVCDSNPMCGNARVQFHKLQTARDNGTLDKVVGLARQLQSTRSPQTVSAVVNDLGRSLNSVVRSLKSLGLDNPDAARARLISMQNGANDLASAGRQVADGVQMLVDQTKNMGIGLNQASAFLMAMGNDASQPSMAGFNVPPQVLKSEEFKKVAQAFISPDGHTVRYFIQTDLNPFSTAAMDQVNTIIDTAKGAQPNTSLADASISMSGYPVMLRDIRDYYERDMRLIVAVTVVVVILILMALLRAIVAPLYLVGSVVISYMSAIGLGVVVFQVFLGQELHWSVPGLAFVVLVAVGADYNMLLASRLRDESALGVRSSVIRTVRCTGGVITAAGLIFAASMSGLLFSSIGTVVQGGFIIGVGILIDTFVVRTITVPAMATLLGRASWWPGHPWQRCAPEEGQMSARMSARTKTVFQAVADGSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI56</accession>
    <name>A0A7U8TI56_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405867.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="91" mass="9044" checksum="5BBF133365E8B90D" modified="2021-06-02" version="1">MGALGTVRGLQDSNTAFVGALHSGNLLGATGAVLQAPGNAVNGFLFGQTSISQSIDVSPEYGYELVAVSDPVGGTAGSARAGHGYVHADLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI80</accession>
    <name>A0A7U8TI80_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <shortName evidence="4">PHS</shortName>
            <ecNumber evidence="4">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Pterin carbinolamine dehydratase</fullName>
            <shortName evidence="4">PCD</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="4"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406082.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI80"/>
    <dbReference type="GeneID" id="45425131"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="94" mass="10380" checksum="21F1A514995CE65A" modified="2021-06-02" version="1">MAVLTDEQVDAALHDLNGWQRAGGVLRRSIKFPTFMAGIDAVRRVAERAEEVNHHPDIDIRWRTVTFALVTHAVGGITENDIAMAHDIDAMFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TID3</accession>
    <name>A0A7U8TID3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406322.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TID3"/>
    <dbReference type="GeneID" id="45425217"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="89" mass="9767" checksum="579ABC9A1A59045B" modified="2021-06-02" version="1">MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSNDEIRNRYTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIL0</accession>
    <name>A0A7U8TIL0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="4">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Cobinamide/cobalamin adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03496</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="4"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406839.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIL0"/>
    <dbReference type="GeneID" id="45425287"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016030">
        <property type="entry name" value="CblAdoTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036451">
        <property type="entry name" value="CblAdoTrfase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029499">
        <property type="entry name" value="PduO-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12213">
        <property type="entry name" value="PTHR12213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01923">
        <property type="entry name" value="Cob_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89028">
        <property type="entry name" value="SSF89028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00636">
        <property type="entry name" value="PduO_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cob_adeno_trans" evidence="5">
        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="193" mass="20694" checksum="2FB302A9F5A5208B" modified="2021-06-02" version="1">MAVHLTRIYTRTGDDGTTGLSDMSRVAKTDARLVAYADCDEANAAIGAALALGHPDTQITDVLRQIQNDLFDAGADLSTPIVENPKHPPLRIAQSYIDRLEGWCDAYNAGLPALKSFVLPGGSPLSALLHVARTVVRRAERSAWAAVDAHPEGVSVLPAKYLNRLSDLLFILSRVANPDGDVLWRPGGDRTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR48</accession>
    <name>A0A7U8TR48_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AraC/xylS-family virulence-regulating transcriptional regulator virS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="236"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="340" mass="37832" checksum="CC0AE5640D3BEF75" modified="2021-06-02" version="1">MELGSLIRATNLWGYTDLMRELGADPLPFLRRFDIPPGIEHQEDAFMSLAGFVRMLEASAAELDCPDFGLRLARWQGLGILGPVAVIARNAATLFGGLEAIGRYLYVHSPALTLTVSSTTARSNVRFGYEVTEPGIPYPLQGYELSMANAARMIRLLGGPQARARVFSFRHAQLGTDAAYREALGCTVRFGRTWCGFEVDHRLAGRPIDHADPETKRIATKYLESQYLPSDATLSERVVGLARRLLPTGQCSAEAIADQLDMHPRTLQRRLAAEGLRCHDLIERERRAQAARYLAQPGLYLSQIAVLLGYSEQSARNRSCRRWFGMTPRQYRAYGGVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR85</accession>
    <name>A0A7U8TR85_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="14" type="ORF">TBLG_03730</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900633.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR85"/>
    <dbReference type="GeneID" id="45427108"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="21"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD14832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="359" mass="39960" checksum="D6176DCBD467AE66" modified="2021-06-02" version="1">MSTPTLPDMVAPSPRVRVKDRCRRMMGDLRLSVIDQCNLRCRYCMPEEHYTWLPRQDLLSVKEISAIVDVFLSVGVSKVRITGGEPLIRPDLPEIVRTLSAKVGEDSGLRDLAITTNGVLLADRVDGLKAAGMKRITVSLDTLQPERFKAISQRNSHDKVIAGIKAVAAAGFTDTKIDTTVMRGANHDELADLIEFARTVNAEVRFIEYMDVGGATHWAWEKVFTKANMLESLEKRYGRIEPLPKHDTAPANRYALPDGTTFGIIASTTEPFCATCDRSRLTADGLWLHCLYAISGINLREPLRAGATHDDLVETVTTGWRRRTDRGAEQRLAQRERGVFLPLSTLKADPHLEMHTRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR96</accession>
    <name>A0A7U8TR96_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03745</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900636.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="289" mass="32305" checksum="B47BCE0603D4C57C" modified="2021-06-02" version="1">MQFNVLGPLELNLRGTKLPLGTPKQRAVLAMLLLSRNQVVAADALVQAIWEKSPPARARRTVHTYICNLRRTLSDAGVDSRNILVSEPPGYRLLIGDRQQCDLDRFVAAKESGLRASAKGYFSEAIRYLDSALQNWRGPVLGDLRSFMFVQMFSRALTEDELLVHTKLAEAAIACGRADVVIPKLERLVAMHPYRESLWKQLMLGYYVNEYQSAAIDAYHRLKSTLAEELGVEPAPTIRALYHKILRQLPMDDLVGRVTRGRVDLRGGNGAKVEELTESDKDLLPIGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRD9</accession>
    <name>A0A7U8TRD9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="60" mass="6859" checksum="04A3D28B597D3BFB" modified="2021-06-02" version="1">MVAPIRFAAPRAAPGMSECAAIVTRREDREMGKQGDRKARKQRAQEREQHRRQASANREP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRI1</accession>
    <name>A0A7U8TRI1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03876</name>
        <name evidence="2" type="ORF">TBLG_03881</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416966.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="280" mass="30689" checksum="B7B223D207315AD4" modified="2021-06-02" version="1">MSPRVPRLRWDDPFRALDMLASLWSSTGMSLVSAGAAQAVAAPYRTLFTTLQQLLIGKEVTVRIGDHDVVLTVTELDSALEPQGLAVGQLGEVRVAARGISWDQHHLHSAVAVLRNVHIRPGVPPLVIAAPVELSSALPTEIFDDVLRQATPQLRGELSESGAARLRWARRPDWGGLEVDVDVAGTTSQTTLWLRPRTVITGQRRWTLPARTPAYRVPLPELPHGLRITDVSLAADCLQLSALLPEWRTELPLRYLESVITQLSQGALSFVWPPLRSGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRJ3</accession>
    <name>A0A7U8TRJ3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRJ3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="110" mass="12476" checksum="ABCB54B8D1133E27" modified="2021-06-02" version="1">MRGHVAEVNGGVAAMALWFLNFSTWDGVAGIYVEDLFVWPRFRRRGLARGLLSTLARECVDNRYTRLAWSVLNWNSDAIALYDRIGGQPQHEWTIYRLSGPRLAALAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRK3</accession>
    <name>A0A7U8TRK3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrolipoamide dehydrogenase lpdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03942</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="4"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="352"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="189"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="471" mass="49193" checksum="C2F962D3EE2D727D" modified="2021-06-02" version="1">MVTRIVILGGGPAGYEAALVAATSHPETTQVTVIDCDGIGGAAVLDDCVPSKTFIASTGLRTELRRAPHLGFHIDFDDAKISLPQIHARVKTLAAAQSADITAQLLSMGVQVIAGRGELIDSTPGLARHRIKATAADGSTSEHEADVVLVATGASPRILPSAQPDGERILTWRQLYDLDALPDHLIVVGSGVTGAEFVDAYTELGVPVTVVASQDHVLPYEDADAALVLEESFAERGVRLFKNARAASVTRTGAGVLVTMTDGRTVEGSHALMTIGSVPNTSGLGLERVGIQLGRGNYLTVDRVSRTSATGIYAAGDCTGLLPLASVAAMQGRIAMYHALGEGVSPIRLRTVAATVFTRPEIAAVGVPQSVIDAGSVAARTIMLPLRTNARAKMSEMRHGFVKIFCRRSTGVVIGGVVVAPIASELILPIAVAVQNRITVNELAQTLAVYPSLSGSITEAARRLMAHDDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRL0</accession>
    <name>A0A7U8TRL0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase, cytochrome b556 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03957</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045281">
        <property type="term" value="C:succinate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000104">
        <property type="term" value="F:succinate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039023">
        <property type="entry name" value="SdhC_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41910">
        <property type="entry name" value="PTHR41910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="112" mass="12837" checksum="67B69DC333C484D5" modified="2021-06-02" version="1">MWSWVCHRISGATIFFFLFVHVLDAAMLRVSPQTYNAVLATYKTPIVGLMEYGIVAAVLFHALNGIRVILIDFWSEGPRYQRLMLWIIGSVFLLLMVPAGVVVGIHMWEHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN2</accession>
    <name>A0A7U8TRN2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">TBLG_03983</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418017.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRN2"/>
    <dbReference type="GeneID" id="45427412"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD15085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="102" mass="11612" checksum="C38A6774457F71BA" modified="2021-06-02" version="1">MPQPEQLPGPNADIWNWQLQGLCRGMDSSMFFHPDGERGRARTQREQRAKEMCRRCPVIEACRSHALEVGEPYGVWGGLSESERDLLLKGTMGRTRGIRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRP8</accession>
    <name>A0A7U8TRP8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_04017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417916.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRP8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="130" mass="14317" checksum="39C93D9ADFC94AA0" modified="2021-06-02" version="1">MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAGGLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRV1</accession>
    <name>A0A7U8TRV1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417435.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005274">
        <property type="entry name" value="IM_pro_YhjD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035875">
        <property type="entry name" value="RNase_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00766">
        <property type="entry name" value="TIGR00766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="289" mass="31293" checksum="FD1AB3C1C33A82DF" modified="2021-06-02" version="1">MGELAEPGVLDRLRARFGWLDHVVRAFTRFNDRNGSLFAAGLTYYTIFAIFPLLMVGFGVGGFALSRRPELLTTLEERIRTSVSGAVGQQLVDLMNSAIDARASVGVIGLATAAWVGLGWMWHLREALSQMWAHPVAPAGYLRTKLSDLAAMVGTFVVIVATIALTVLGHARPMAAVLRWLEIPQFSVFDEIFRGISVLVSVLVSWVLFTWMIGRLPREPVGLVTAARAGLMAAVGFELFKQVGAIYLQIVLRSPAGAVFGPVLGLMVFAFVTAWLILFATAWAATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRV8</accession>
    <name>A0A7U8TRV8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Secreted serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_04103</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023834">
        <property type="entry name" value="T7SS_pept_S8A_mycosin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03921">
        <property type="entry name" value="T7SS_mycosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="12">
        <location>
            <begin position="9"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD15209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="344" mass="34191" checksum="2977636871BF2ADA" modified="2021-06-02" version="1">PGGDYVFTGDGTADCDAHGTLVAGIIAAAPDAQSDNFSGVAPDVTLISIRQSSSKFAPVGDPSSTGVGDVDTMAKAVRTAADLGASVINISSIACVPAAAAPDDRALGAALAYAVDVKNAVIVAAAGNTGGAAQCPPQAPGVTRDSVTVAVSPAWYDDYVLTVGSVNAQGEPSAFTLAGPWVDVAATGEAVTSLSPFGDGTVNRLGGQHGSIPISGTSYAAPVVSGLAALIRARFPTLTARQVMQRIESTAHHPPAGWDPLVGNGTVDALAAVSSDSIPQAGTATSDPAPVAVPVPRRSTPGPSDRRALHTAFAGAAICLLALMATLATASRRLRPRRNGIAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRW4</accession>
    <name>A0A7U8TRW4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900033.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRW4"/>
    <dbReference type="GeneID" id="45427358"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="11"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="396" mass="42835" checksum="2B8A8DF27E719847" modified="2021-06-02" version="1">MAPGSCEAPDVFNPAKLGPLTLRNRVIKAATFEARTPDALVTDDLIEYHRLPAAGGVAMTTVAYCAVSPGGRTGGNQIWMRPHAVPGLRRLTEAIHAEGAAISAQIGHAGPVADARSNQATALAPVRFFNPIAMRFAQKATREDIDDVLAAHAHAARLAVDAGFDAVEIHLGHNYLASAFLSPLLNRRDDEFGGSLQNRAKVARGLVMAVRRAVRQQVAVTAKLNMTDGIRGGITVDEALTTARWLQDDGGLDAIELTAGSSLVNPMYLFRGDAPVKEFAAAFKPPLRWGIRMTGHRFFREYPYRDAYLLREARLFRAELTIPLILLGGITNRTTMDLAMAEGFEFVAMARALLAEPDLVNRIAAEGSQVRSACTHCNQCMATIYRRTHCVVTGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRX9</accession>
    <name>A0A7U8TRX9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418931.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025971">
        <property type="entry name" value="LppP/LprE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14041">
        <property type="entry name" value="Lipoprotein_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="220" mass="22983" checksum="AA4AE3BED7A08DDE" modified="2021-06-02" version="1">MSDEIDPDWPAPAYQPSDDVDTTPPAPGGSWPTAWLVALVVLACVAAAVVAYAGMHRVRPGANQAAPATTSAPARPTSPASQVGPCGPDEATAVRAALAQLAPDSKTGRPWNSTPEDSNYDPCADLSAVLVTVQDATNSSPDQALMFHRGTFVGTATPRAYPFTNLIGPASTNDIVVLSYRTRQSCDGCQDGILTIVGFAWRGDHVQILDSLPELFDAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSX7</accession>
    <name>A0A7U8TSX7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4129 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900649.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025403">
        <property type="entry name" value="DUF4129"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13559">
        <property type="entry name" value="DUF4129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4129" evidence="3">
        <location>
            <begin position="237"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="319" mass="33396" checksum="7066F7D8809899CF" modified="2021-06-02" version="1">MPGTKPGSDKPTGRVVVVIVLLMLAGAALRGHLPADDGAPLAAAGGSRAALMFIVAALAATLALIALAIITRLRHPLPVAPSAGELSAMLGGAAGRPNWRVLLLGLGTILAWLLIAILLARLFVPDDVGPAAPIPDSTATPDASSTTPSRPQPPQDNNDDVLGILFASTIGLFLMVVAGSLITSRRQRKSAPARISGDRIESPAPSARSESLARAAEIGLAEMADLRREPREAIIACYVAMERELSHVPGVAPQDFDTPTEVLARAVEHRALHGASAAALVSLFAEARFSPHVMNEEHREVAMRLLRLVLDELSTRTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT24</accession>
    <name>A0A7U8TT24_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416883.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT24"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="321" mass="34475" checksum="164014C4944CC4C9" modified="2021-06-02" version="1">MRAVLIVNPTATATTPAGRDLLAHALESRLQLTVEHTNHRGHGTELGQAAVADGVDLVVVHGGDGTVSAVVNGMLGRPGTTPVRPVPAVAVVPGGSANVLARALGISADPIAATNQLIQLLDDYGRHQQWRRIGLIDCGERWAVFNAGMGVDAEVVAAVEAERDKGGKVTAWRYIRAAVRAVLACTRREPALTLQLPNRDPITGVHFVFVSNSSPWTYANNRPVWTNPDCRFESGLGVFATTSMKVVPTLRVVRQMFAKQPKFEFNHVINNDDVACLRVTSMGPPIASQFDGDYLGVRETMTFRAVPDALAVVAPPARKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT62</accession>
    <name>A0A7U8TT62_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT62"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="176" mass="18885" checksum="BA98FC9805E1EBCE" modified="2021-06-02" version="1">MVAARLPFGWPADSGVTADIIEAAMELAIDTARHATAPFGAALLDVTTLRAFSGGNTYFESGDRFAHAETNVLRAAMSTLPELSNHVLISTAEPCPMCAAASVLSGVRAIIFGTSIETLIQCGWFQIRISASDVVAASTRPTRPSVYSGFLSHKTDLLYRNSENRRAMNPWTDPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTL9</accession>
    <name>A0A7U8TTL9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">APH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05154">
        <property type="entry name" value="ACAD10_11_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041726">
        <property type="entry name" value="ACAD10_11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="290" mass="33327" checksum="1EE25CD9DCC092E2" modified="2021-06-02" version="1">MFPTYRLDHQFEVIRLVGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVPPDVMPYTFGDNWFADAPAERQRQLQDATVAALATLHSIPNAQNTFSFLTQGRTSDTTLHRHFNWVRSWYDFAVEGIGRSPLLERTFEWLQSHWPDDAAAREPVLLWGDARVGNVLYRDFQPVAVLDWEMVALGPRELDVAWMIFAHRVFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSGVMWACVFMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTM5</accession>
    <name>A0A7U8TTM5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MCE-family lipoprotein mce4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418964.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTM5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="384" mass="41293" checksum="D033E406C2D13AD6" modified="2021-06-02" version="1">MNRIWLRAIILTASSALLAGCQFGGLNSLPLPGTAGHGEGAYSVTVEMADVATLPQNSPVMVDDVTVGSVAGIVAVQRPDGSFYAAVKLDLDKNVLLPANAVAKVSQTSLLGSLHVELAPPTDRPPTGRLVDGSRITEANTDRFPTTEEVFSALGVVVNKGNVGALEEIIDETHQAVAGRQAQFVNLVPRLAELTAGLNRQVHDIIDALDGLNRVSAILARDKDNLGRALDTLPDAVRVLNQNRDHIVDAFAALKRLTMVTSHVLAETKVDFGEDLKDLYSIVKALNDDRKDFVTSLQLLLTFPFPNFGIKQAVRGDYLNVFTTFDLTLRRIGETFFTTAYFDPNMAHMDEILNPPDFLIGELANLSGQAADPFKIPPGTASGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTZ9</accession>
    <name>A0A7U8TTZ9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein yrbE4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418986.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTZ9"/>
    <dbReference type="GeneID" id="45427487"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="254" mass="26640" checksum="F93B3BE178D2DBC3" modified="2021-06-02" version="1">MIQQLAVPARAVGGFFEMSMDTARAAFRRPFQFREFLDQTWMVARVSLVPTLLVSIPFTVLVAFTLNILLREIGAADLSGAGTAFGTITQLGPVVTVLVVAGAGATAICADLGARTIREEIDAMRVLGIDPIQRLVVPRVLASTLVALLLNGLVCAIGLSGGYAFSVFLQGVNPGAFINGLTVLTGLRELILAEIKALLFGVMAGLVGCYRGLTVKGGPKGVGNAVNETVVYAFICLFVINVVMTAIGVRISAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y211</accession>
    <name>A0A7U8Y211_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y211"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="64"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="156" mass="16595" checksum="B014C305809C60B2" modified="2021-06-02" version="1">MALVLAAAGAVTVVQFRDAAHEADPDGALRGLTDDITADLVRELVTILPIVLVIAAVAAYLLSRAALRPVDRIRAAAQTLTTTPHPDTDAPLPVPPTDDEIAWLATTLNTMLTRLQRALAHEQQFVADASHELRTPLALLTTELELRCAGPDPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y227</accession>
    <name>A0A7U8Y227_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_02763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016741">
        <property type="entry name" value="UCP018953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018953">
        <property type="entry name" value="UCP018953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FIST" evidence="7">
        <location>
            <begin position="32"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="8">
        <location>
            <begin position="221"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="383" mass="39634" checksum="8C2CF14886BF2D99" modified="2021-06-02" version="1">MRIGVGVSTAPDVRRAAAEAAAHAREELAGGTPALAVLLGSRSHTDQAVDLLAAVQASVEPAALIGCVAQGIVAGRHELENEPAVAVWLASGPPAETFHLDFVRTGSGALITGYRFDRTAHDLHLLLPDPYSFPSNLLIEHLNTDLPGTTVVGGVVSGGRRRGDTRLFRDRDVLTSGLVGVRLPGAHSVSVVSQGCRPIGEPYIVTGADGAVITELGGRPPLHRLREIVLGMAPDEQELVSRGLQIGIVVDEHLAVPGQGDFLIRGLLGADPTTGAIGIGEVVEVGATVQFQVRDAAAADKDLRLAVERVAAELPGPPVGGLLFTCNGRGRRMFGVTDHDASTIEDLLGGIPLAGFFAAGEIGPVAGHNALHGFTASMALFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2I8</accession>
    <name>A0A7U8Y2I8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402915.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424514"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009956">
        <property type="entry name" value="Post-segregation_anti-tox_CcdA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07362">
        <property type="entry name" value="CcdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="88" mass="9544" checksum="82A6144124328836" modified="2021-06-02" version="1">MLSRRTKTIVVCTLVCMARLNVYVPDELAERARARGLNVSALTQAAISAELENSATDAWLEGLEPRSTGARHDDVLGAIDAARDEFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2J8</accession>
    <name>A0A7U8Y2J8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved alanine and proline rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="234" mass="24082" checksum="A1D90905B3A3D0B8" modified="2021-06-02" version="1">MPTIWTFVRAAAVLVGFFRRTTYGRYRSRRSAPAPAPAPNIPQQADQLGRQRTRKFLQNLRQRSGRPLPPLSAPQSCGTRPRRPRDNRHLSKTGAGGPAASRGPRANSVHFPGVNAPIPGNNPGGTGASPSTAPGGQLRPFPGGNAPDPGGLTRTGPGGGPRCRPPFPGVPSAKVDLPQLPYLPLQVPQQLSLPADLPALASGVIPAAPIAPTPPAPGAPALPPGPPSLLAALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2K8</accession>
    <name>A0A7U8Y2K8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="3">1.2.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900286.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2K8"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="9">
        <location>
            <begin position="53"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="543" mass="58841" checksum="61454C51BDD42D9C" modified="2021-06-02" version="1">MDAITQVPVPANEPVHDYAPKSPERTRLRTELASLADHPIDLPHVIGGRHRMGDGERIDVVQPHRHAARLGTLTNATHADAAAAVEAAMSAKSDWAALPFDERAAVFLRAADLLAGPWREKIAAATMLGQSKSVYQAEIDAVCELIDFWRFNVAFARQILEQQPISGPGEWNRIDYRPLDGFVYAITPFNFTSIAGNLPTAPALMGNTVIWKPSITQTLAAYLTMQLLEAAGLPPGVINLVTGDGFAVSDVALADPRLAGIHFTGSTATFGHLWQWVGTNIGRYHSYPRLVGETGGKDFVVAHASARPDVLRTALIRGAFDYQGQKCSAVSRAFIAHSVWQRMGDELLAKAAELRYGDITDLSNYGGALIDQRAFVKNVDAIERAKGAAAVTVAVGGEYDDSEGYFVRPTVLLSDDPTDESFVIEYFGPLLSVHVYPDERYEQILDVIDTGSRYALTGAVIADDRQAVLTALDRLRFAAGNFYVNDKPTGAVVGRQPFGGARGSGTNDKAGSPLNLLRWTSARSIKETFVAATDHIYPHMAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2L8</accession>
    <name>A0A7U8Y2L8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="180" mass="20475" checksum="0CF59BDAAF170700" modified="2021-06-02" version="1">MSKPFAPRRLYTPRTSRTLAPRLDPEAVGRTTESIARFFGTGRYLLVQTLLVLTWIVLNLFAVGLRWDPYPFILLYLAFSTQASYAAPLILLAQNHQEKRDRAVFEEDRRRAAQTKADTEYNARELAALRLAIGEVPTRDYLRHELDSLRALLAELQPTDPDVAQPRVADEAEQHAKKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2P2</accession>
    <name>A0A7U8Y2P2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="134" mass="14350" checksum="01A33E32C745031D" modified="2021-06-02" version="1">PVRASEGCQRCDLAVPGFPTDLQPMAIALASIADGTSMITENVFEARFRFVEEMIRLGADARTDGHHAVVRGLPQLSSAPVWCSDIRAGAGLVLAGLVADGDTEVHDVFHIDRGYPLFVENLVSLGAEIERVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2R2</accession>
    <name>A0A7U8Y2R2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008585">
        <property type="entry name" value="Gamma_PGA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038128">
        <property type="entry name" value="Gamma_PGA_hydro_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05908">
        <property type="entry name" value="Gamma_PGA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="354" mass="39031" checksum="AD73AE47B37A4CD3" modified="2021-06-02" version="1">MPDRRHPYFAYGSNLCAHQMASRCPDAGAPRPAVLSDHNWLINQRGVATVEPFAGNKVHGVLWQLSERDLVRLDSAEGVPVRYRRERLTVHTDDTALPAWVYIDHRVMPGRPRPGYLPRVIDGARHHGLPQRWIDYLHRWDPARWPLPVLPSSRSGPAPQSLSELLSQPGVIETSQLRSRFGFLAIHGGGLEQATDLIAERSAEAAGASVYLLRHPDNYPHHLPSARFDPAESARLAEFLDHVDVAVSLHGYDRIGRSTQLLAGGRNRALAAHLARHIQLPGYRVVTDLAAIPEELRGLHPDNPVNRVRDGGTQLELSIRVRGLGPRSTLPGVGGMSPVTATLVQGLVTAARSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2R7</accession>
    <name>A0A7U8Y2R7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA ligase (ATP)</fullName>
            <ecNumber evidence="2">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">NHEJ DNA polymerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TBLG_03096</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04863">
        <property type="entry name" value="MtLigD_Pol_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014146">
        <property type="entry name" value="LigD_ligase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014144">
        <property type="entry name" value="LigD_PE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014145">
        <property type="entry name" value="LigD_pol_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033649">
        <property type="entry name" value="MtLigD_Pol-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13298">
        <property type="entry name" value="LigD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02777">
        <property type="entry name" value="LigD_PE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02778">
        <property type="entry name" value="ligD_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02779">
        <property type="entry name" value="NHEJ_ligase_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="547"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="743"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFD12512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="759" mass="83636" checksum="511B335C7B5674EB" modified="2021-06-02" version="1">MGSASEQRVTLTNADKVLYPATGTTKSDIFDYYAGVAEVMLGHIAGRPATRKRWPNGVDQPAFFEKQLALSAPPWLSRATVAHRSGTTTYPIIDSATGLAWIAQQAALEVHVPQWRFVAEPGSGELNPGPATRLVFDLDPGEGVMMAQLAEVARAVRDLLADIGLVTFPVTSGSKGLHLYTPLDEPVSSRGATVLAKRVAQRLEQAMPALVTSTMTKSLRAGKVFVDWSQNSGSKTTIAPYSLRGRTHPTVAAPRTWAELDDPALRQLSYDEVLTRIARDGDLLERLDADAPVADRLTRYRRMRDTSKTPEPIPTAKPVTGDGNTFVIQEHHARRPHYDFRLERDGVLVSWAVPKNLPDNTSVNHLAIHTEDHPLEYATFEGAIPSGEYGAGKVIIWDSGTYDTEKFHDDPHTGEVIVNLHGGRISGRYALIRTNGDRWLAHRLKNQKDQKVFEFDNLAPMLATHGTVAGLKASQWAFEGKWDGYRLLVEADHGAVRLRSRSGRDVTAEYPQLRALAEDLADHHVVLDGEAVVLDSSGVPSFSQMQNRGRDTRVEFWAFDLLYLDGRALLGTRYQDRRKLLETLANATSLTVPELLPGDGAQAFACSRKHGWEGVIAKRRDSRYQPGRRCASWVKDKHWNTQEVVIGGWRAGEGGHSSGVGSLLMGIPGPGGLQFAGRVGTGLSERELANLKEMLAPLHTDESPFDVPLPARDAKGITYVKPALVAEVRYSEWTPEGRLRQSSWRGLRPDKKPSEVVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2S6</accession>
    <name>A0A7U8Y2S6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407378.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013228">
        <property type="entry name" value="PE-PPE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08237">
        <property type="entry name" value="PE-PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PE-PPE" evidence="3">
        <location>
            <begin position="149"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="528" mass="54584" checksum="3D27409215D347A9" modified="2021-06-02" version="1">MSFVFAVPEMVAATASDLASLGAALSEATAAAAIPTTQVLAAAADEVSAAIAELFGAHGQEFQALSAQASAFHDRFVRALSAAAGWYVDAEAANAALVDTAATGASELGSGGRTALILGSTGTPRPPFDYMQQVYDRYIAPHYLGYAFSGLYTPAQFQPWTGIPSLTYDQSVAEGAGYLHTAIMQQVAAGNDVVVLGFSQGASVATLEMRHLASLPAGVAPSPDQLSFVLLGNPNNPNGGILARFPGLYLQSLGLTFNGATPDTDYATTIYTTQYDGFADFPKYPLNILADVNALLGIYYSHSLYYGLTPEQVASGIVLPVSSPDTNTTYILLPNEDLPLLQPLRGIVPEPLLDLIEPDLRAIIELGYDRTGYADVPTPAALFPVHIDPIAVPPQIGAAIGGPLTALDGLLDTVINDQLNPVVTSGIYQAGAELSVAAAGYGAPAGVTNAIFIGQQVLPILVEGPGALVTADTHYLVDAIQDLAAGDLSGFNQNLQLIPATNIALLVFAAGIPAVAAVAILTGQDFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2X7</accession>
    <name>A0A7U8Y2X7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405871.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2X7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="107" mass="12050" checksum="61F04577CD12F4A7" modified="2021-06-02" version="1">MIFIVVKFETKPEWTERWPDLVASFTAATRAEEGNLWFEWSRSLDDPAEYVLVESFRDGEAGGVHVNSDHFRQAMRELPKALASTPKIISQTIDATGWSAMGEMTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Y2</accession>
    <name>A0A7U8Y2Y2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cobalamin-independent methionine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Methionine synthase, vitamin-B12 independent isozyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">metE</name>
        <name evidence="14" type="ORF">TBLG_03306</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21196"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58140"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
            <dbReference type="EC" id="2.1.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the vitamin-B12 independent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.14" evidence="10"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405914.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Y2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00082"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00172">
        <property type="entry name" value="Meth_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013215">
        <property type="entry name" value="Cbl-indep_Met_Synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006276">
        <property type="entry name" value="Cobalamin-indep_Met_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08267">
        <property type="entry name" value="Meth_synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000382">
        <property type="entry name" value="MeTrfase_B12_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01371">
        <property type="entry name" value="met_syn_B12ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 10 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Meth_synt_1" evidence="13">
        <location>
            <begin position="12"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Meth_synt_2" evidence="12">
        <location>
            <begin position="432"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-homocysteine binding" evidence="10">
        <location>
            <begin position="437"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-methionine binding" evidence="10">
        <location>
            <begin position="437"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-methyltetrahydropteroyltri-L-glutamate binding" evidence="10">
        <location>
            <begin position="521"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="700"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="567"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="611"/>
        </location>
        <ligand>
            <name>5-methyltetrahydropteroyltri-L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:58207"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="732"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="759" mass="81582" checksum="702F90BF79B25C8D" modified="2021-06-02" version="1">MTQPVRRQPFTATITGSPRIGPRRELKRATEGYWAGRTSRSELEAVAATLRRDTWSALAAAGLDSVPVNTFSYYDQMLDTAVLLGALPPRVSPVSDGLDRYFAAARGTDQIAPLEMTKWFDTNYHYLVPEIGPSTTFTLHPGKVLAELKEALGQGIPARPVIIGPITFLLLSKAVDGAGAPIERLEELVPVYSELLSLLADGGAQWVQFDEPALVTDLSPDAPALAEAVYTALCSVSNRPAIYVATYFGDPGAALPALARTPVEAIGVDLVAGADTSVAGVPELAGKTLVAGVVDGRNVWRTDLEAALGTLATLLGSAATVAVSTSCSTLHVPYSLEPETDLDDALRSWLAFGAEKVREVVVLARALRDGHDAVADEIASSRAAIASRKRDPRLHNGQIRARIEAIVASGAHRGNAAQRRASQDARLHLPPLPTTTIGSYPQTSAIRVARAALRAGEIDEAEYVRRMRQEITEVIALQERLGLDVLVHGEPERNDMVQYFAEQLAGFFATQNGWVQSYGSRCVRPPILYGDVSRPRAMTVEWITYAQSLTDKPVKGMLTGPVTILAWSFVRDDQPLADTANQVALAIRDETVDLQSAGIAVIQVDEPALRELLPLRRADQAEYLRWAVGAFRLATSGVSDATQIHTHLCYSEFGEVIGAIADLDADVTSIEAARSHMEVLDDLNAIGFANGVGPGVYDIHSPRVPSAEEMADSLRAALRAVPAERLWVNPDCGLKTRNVDEVTASLHNMVAAAREVRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Z8</accession>
    <name>A0A7U8Y2Z8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="275" mass="30048" checksum="F2AF0BE9F6DA807B" modified="2021-06-02" version="1">MTMKSLAALDRPSWLSSSAWPWQPYLLSHHQGGIAVTDIGDGPAVLFVHVGSWSFVWRDVLLRLANDFRCVAIDAPGCGLSDRLSTPPTLAQAADAITSVIDALQLRDLTLVAHDLGGPAGFLAAARRGDRVAALAAVNCFAWRPTGPLFRGMLAAMGSAPVRELDAAINALARATSTRFGAGRHWSRADRAAFRAGIDAPARRAWHAYFRDARRAHAPLYRRRRPRLRGGLADRPLLTIFGQFNDPLRFQPRWKELFPTARQLAGPPGQPLSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y373</accession>
    <name>A0A7U8Y373_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgl</name>
        <name evidence="9" type="ORF">TBLG_03636</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407433.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y373"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD13052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="247" mass="25804" checksum="1639B68A595D7D2C" modified="2021-06-02" version="1">MSSSIEIFPDSDILVAAAGKRLVGAIGAAVAARGQALIVLTGGGNGIALLRYLSAQAQQIEWSKVHLFWGDERYVPEDDDERNLKQARRALLNHVDIPSNQVHPMAASDGDFGGDLDAAALAYEQVLAASAAPGDPAPNFDVHLLGMGPEGHINSLFPHSPAVLESTRMVVAVDDSPKPPPRRITLTLPAIQRSREVWLLVSGPGKADAVAAAIGGADPVSVPAAGAVGRQNTLWLLDRDAAAKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4E2</accession>
    <name>A0A7U8Y4E2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Divalent metal cation transporter MntH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mntH</name>
        <name evidence="5" type="ORF">TBLG_03082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">H(+)-stimulated, divalent metal cation uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NRAMP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898649.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4E2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00221">
        <property type="entry name" value="NRAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01197">
        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="428" mass="45004" checksum="D90CF98756715CD8" modified="2021-06-02" version="1">MAGEFRLLSHLCSRGSKVGELAQDTRTSLKTSWYLLGPAFVAAIAYVDPGNVAANVSSGAQFGYLLLWVIVAANVMAALVQYLSAKLGLVTGRSLPEAIGKRMGRPARLAYWAQAEIVAMATDVAEVIGGAIALRIMFNLPLPIGGIITGVVSLLLLTIQDRRGQRLFERVITALLLVIAIGFTASFFVVTPPPNAVLGGLAPRFQGTESVLLAAAIMGATVMPHAVYLHSGLARDRHGHPDPGPQRRRLLRVTRWDVGLAMLIAGGVNAAMLLVAALNMRGRGDTASIEGAYHAVHDTLGATIAVLFAVGLLASGLASSSVGAYAGAMIMQGLLHWSVPMLVRRLITLGPALAILTLGFDPTRTLVLSQVVLSFGIPFAVLPLVKLTGSPAVMGGDTNHRATTWVGWVVAVMVSLLNVMLIYLTVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4F5</accession>
    <name>A0A7U8Y4F5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="2">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4F5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="114"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="242" mass="25980" checksum="C0E14A8DA7550AF8" modified="2021-06-02" version="1">MHGARTGVSFYAYAMTDHDQTAARREIADALLAALERRHEVADAIVEAANKAAAVEAIVNLLGTSHLAAEAVMSMSFDQLTQDARTKIIAELDDLNKQLSFTVKERPASSGEGLELRPFSPDEDRDIFARRTEEMGAAGDGSGGPAGSVDDEIRAAQKRVDDEEAAWFVAVDSGVKVGMVFGELVHGEVDVRIWIHPDHRKKGYGTAALRKSRSEMAWAFPAVPMVARAPAAQPAQPGSAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4G8</accession>
    <name>A0A7U8Y4G8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione hydrolase proenzyme</fullName>
            <ecNumber evidence="4">2.3.2.2</ecNumber>
            <ecNumber evidence="4">3.4.19.13</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase large chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="4">Glutathione hydrolase small chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 4">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>an alpha-amino acid + an N-terminal (5-L-glutamyl)-[peptide] = 5-L-glutamyl amino acid + N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">This enzyme consists of two polypeptide chains, which are synthesized in precursor form from a single polypeptide.</text>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by autocatalysis into a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="4"/>
    <dbReference type="EC" id="3.4.19.13" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403933.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4G8"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="512" mass="54593" checksum="68F2AEAB79ED3817" modified="2021-06-02" version="1">MPILATNVVCTSQPLAAQAGLRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGLNASGRSPSAWTPEYFGGNAVPVLGWNSVTVPGAVSAWVELHARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFADAFMPGGRAPKPGELFTFPDHAATLEKIAATNGEEFYRGELAAKLEAHSAANGGVMRADDLAAHRVDWVDTITGTYRGYTIHQIPPNGQGIVALIALGILEHFDMSSWSVDSAESVHVQIEALKLAFADAQACVADIDYMPVHPKRLLDKEYLRQRATLIDPKRAMPAATGIPRGGTVYLAAADAAGMMVSMIQSNYLGFGSGVVVPGTGISLHNRGSDFTVVPRHPNRVGPRKRPYHTIIPGFVTRDGAPVMSFGVMGGMMQPQGHVQVLVRIADYGQNPQAACDGPRFRWVNGMRVSFENGFPDSTLDELRQRGHDLVAVADYSQFGSCQAIWRLDDGYLAASDPRRDGQAAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4H6</accession>
    <name>A0A7U8Y4H6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Enolase</fullName>
            <ecNumber evidence="8">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">eno</name>
        <name evidence="13" type="ORF">TBLG_03187</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell surface</location>
        </subcellularLocation>
        <text evidence="8">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="8"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4H6"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="11">
        <location>
            <begin position="138"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 9">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8 9">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="8">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="429" mass="44862" checksum="F808FB8E0D891C9A" modified="2021-06-02" version="1">MPIIEQVGAREILDSRGNPTVEVEVALIDGTFARAAVPSGASTGEHEAVELRDGGDRYGGKGVQKAVQAVLDEIGPAVIGLNADDQRLVDQALVDLDGTPDKSRLGGNAILGVSLAVAKAAADSAELPLFRYVGGPNAHILPVPMMNILNGGAHADTAVDIQEFMVAPIGAPSFVEALRWGAEVYHALKSVLKKEGLSTGLGDEGGFAPDVAGTTAALDLISRAIESAGLRPGADVALALDAAATEFFTDGTGYVFEGTTRTADQMTEFYAGLLGAYPLVSIEDPLSEDDWDGWAALTASIGDRVQIVGDDIFVTNPERLEEGIERGVANALLVKVNQIGTLTETLDAVTLAHHGGYRTMISHRSGETEDTMIADLAVAIGSGQIKTGAPARSERVAKYNQLLRIEEALGDAARYAGDLAFPRFACETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4L6</accession>
    <name>A0A7U8Y4L6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Outer membrane protein A ompA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404684.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4L6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1 3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="212"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="326" mass="33574" checksum="9E0D46ABCC179F4A" modified="2021-06-02" version="1">MASKAGLGQTPATTDARRTQKFYRGSPGRPWLIGAVVIPLLIAAIGYGAFERPQSVTGPTGVLPTLTPTSTRGASALSLSLLSISRSGNTVTLIGDFPDEAAKAALMTALNGLLAPGVNVIDQIHVDPVVRSLDFSSAEPVFTASVPIPDFGLKVERDTVTLTGTAPSSEHKDAVKRAATSTWPDMKIVNNIEVTGQAPPGPPASGPCADLQSAINAVTGGPIAFGNDGASLIPADYEILNRVADKLKACPDARVTINGYTDNTGSEGINIPLSAQRAKIVADYLVARGVAGDHIATVGLGSVNPIASNATPEGRAKNRRVEIVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4R1</accession>
    <name>A0A7U8Y4R1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007511">
        <property type="entry name" value="DUF501"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37163">
        <property type="entry name" value="PTHR37163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04417">
        <property type="entry name" value="DUF501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="155" mass="16625" checksum="D988E18FEF572BC5" modified="2021-06-02" version="1">MVTRQLGRAPRGVLAIAYRCPNGEPGVVKTAPRLPDGTPFPTLYYLTHPVLTAAASRLETTGLMREMNRRLGQDAELAAAYRRAHESYLSERDALEPLGTTVSAGGMPDRVKCLHVLIAHSLAKGPGLNPFGDEALALLAAEPRTAATLVAGQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y520</accession>
    <name>A0A7U8Y520_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">pyrR</name>
        <name evidence="6" type="ORF">TBLG_03565</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407196.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y520"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="27"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="115"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="193" mass="20627" checksum="07A499B7D4E66159" modified="2021-06-02" version="1">MGAAGDAAIGRESRELMSAADVGRTISRIAHQIIEKTALDDPVGPDAPRVVLLGIPTRGVTLANRLAGNITEYSGIHVGHGALDITLYRDDLMIKPPRPLASTSIPAGGIDDALVILVDDVLYSGRSVRSALDALRDVGRPRAVQLAVLVDRGHRELPLRADYVGKNVPTSRSESVHVRLREHDGRDGVVISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7G7</accession>
    <name>A0A7U8Y7G7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416815.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7G7"/>
    <dbReference type="GeneID" id="45427186"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="98"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="447" mass="49122" checksum="A4283DA59BF6B36C" modified="2021-06-02" version="1">MDDGSVSDIKRGRAARNAKLASIPVGFAGRAALGLGKRLTGKSKDEVTAELMEKAANQLFTVLGELKGGAMKVGQALSVMEAAIPDEFGEPYREALTKLQKDAPPLPASKVHRVLDGQLGTKWRERFSSFNDTPVASASIGQVHKAIWSDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVERTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQRDLIGTLLAELTFDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFGAVAPMPGGFPIELGMTIRLAREKNYDLLLPTMEKAGLIQRGRQVSVREIDEMLRQYVEPIQVEVFHYTRKWLQKMTVSQIDRSVAQIRTARQMDLPAKLAIPMRVIASVGAILCQLDAHVPIKALSEELIPGFAEPDAIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Q4</accession>
    <name>A0A7U8Y7Q4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027948">
        <property type="entry name" value="DUF4436"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14494">
        <property type="entry name" value="DUF4436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="312" mass="33876" checksum="FE1E9B977DF3D3B2" modified="2021-06-02" version="1">MAWRWHPLTEGSRGYNFRAGTHKWAGSELGRILRVVVGLVLVIAAYVTVIALYHSTGLGRPHEVAHGRPTADGTTVTLHVEQLQTIKGVLVANLAVSPGTELLDSQTQGLKDDLTVTVTSVVTPTKRTWSSGSLPGVFPVPLTISGDPANWPFDHYRSGPITVQLYRGAAHAPERVSVTFVDRLPGWNVDISGVGDANVPAPYRVGLHRSPSSVAFGTVIVGVLIALAGVGLFVAVQTARGRRQFQPPMTTWYAAMLFAVIPLRNALPDAPPIGFWIDVTVVLWVVVALVTSMVLYILCWWWHLKPDVDETM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Y3</accession>
    <name>A0A7U8Y7Y3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03691</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901532.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7Y3"/>
    <dbReference type="GeneID" id="45427065"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="3">
        <location>
            <begin position="7"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="DUF190" evidence="3">
        <location>
            <begin position="127"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="DUF190" evidence="3">
        <location>
            <begin position="248"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="369" mass="40466" checksum="6BAE19CDAEA2598E" modified="2021-06-02" version="1">MNEQCLKLTAYFGERQRAVGGAGRFLADAMLDLFGSHNVATSVMLRGTTSFGPKHEFRCDQSLSLSEDPPVTVAAVDIESKIRSLVDDVTAMTDRGLVTLERARLVTRHSGAEEFGDIDSRNGDAAKLTIYAGRQVRVAGAPAYYTICELLHRHGFAGATVLLGVDGTAHGRRRRARFFGRNVNVPLMIIAVGTPAQVAVAAMELTAALPNPLLTIERVRLCKRDGELFARPQQLPQTDDQGRTLWQKLMVHTAEATHHEGLPIHRALVHRLMQSETARGATALRGIWGFYGDHKPHGDKLFQLVRRVPVTTIIVDTPQAIARSFDIVDELTNWHGLVTSEMVPAAVSLTGSRDGTQKTGETPLARYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y866</accession>
    <name>A0A7U8Y866_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="6 10">2.4.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Inosine-guanosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03946</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>a purine 2'-deoxy-D-ribonucleoside + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + a purine nucleobase</text>
            <dbReference type="Rhea" id="RHEA:36431"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="ChEBI" id="CHEBI:142361"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Purine metabolism; purine nucleoside salvage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PNP/MTAP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="6 10"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417233.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y866"/>
    <dbReference type="GeneID" id="45427302"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09009">
        <property type="entry name" value="PNP-EcPNPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011269">
        <property type="entry name" value="PUNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011268">
        <property type="entry name" value="Purine_phosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11904">
        <property type="entry name" value="PTHR11904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000477">
        <property type="entry name" value="PurNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01697">
        <property type="entry name" value="PNPH-PUNA-XAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01698">
        <property type="entry name" value="PUNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="12">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="11">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a purine D-ribonucleoside</name>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000477-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD15048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="268" mass="27572" checksum="12AA429779CE89F6" modified="2021-06-02" version="1">MADPRPDPDELARRAAQVIADRTGIGEHDVAVVLGSGWLPAVAALGSPTTVLPQAELPGFVPPTAAGHAGELLSVPIGAHRVLVLAGRIHAYEGHDLRYVVHPVRAARAAGAQIMVLTNAAGGLRADLQVGQPVLISDHLNLTARSPLVGGEFVDLTDAYSPRLRELARQSDPQLAEGVYAGLPGPHYETPAEIRMLQTLGADLVGMSTVHETIAARAAGAEVLGVSLVTNLAAGITGEPLSHAEVLAAGAASATRMGALLADVIARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y885</accession>
    <name>A0A7U8Y885_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="204" mass="20821" checksum="4CCBFCCBF1BCEB38" modified="2021-06-02" version="1">MTVAFASDQRLENGAEQLESLRRQMALLSEKVSGGPSRSGDLVPAGPVSLPPGTVGVLSGARSLLLSMVASVTAAGGNAAIVGQPDIGLLAAVEMGADLSRLAVIPDPGTDPVEVAAVLIDGMDLVVLGLGGRRVTRARARAVVARARQKGCTLLVTDGDWQGVSTRLAARVCGYEITPALRGVPTPGLGRISGVRLQINGRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA26</accession>
    <name>A0A7U8YA26_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="393" mass="44454" checksum="34B8EDA0A84D7C45" modified="2021-06-02" version="1">ATAQRLQSWDADDLLNTPVDDVVEQLVELGSVECPDLRVDDAFMLPATEVDQQYRDWGEQRTRRVTRLVLVVPFEGHKDIFNLRPDQFTTMPPQVLRLQGHEIHLAIDNPSNDAAAINAAFHKQIANIEKYLGWSRRQIDLHNQGLRNELPGMVARRREQLLATRNLQAEIGFPVRRRKDADTYAAPISRKSVRPRPHRPAGARAAFKPEPAMQDEDYQSALRVLRNQRNALERTPSVAAKLDGEEIRDMLLVGLNAQFEGDAGGELFNGAGKTDILIRVDDRNIFIGECKVWSGPRTMDDALKQLFGYLVWRDTKAAILLFIRNKDVTAVIDNAIAKIKEHPNHKRCPAHRAGADQYEFTMHADGDPEREIHLTLIPFALRPTAEVPTTTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA44</accession>
    <name>A0A7U8YA44_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA44"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="62" mass="6498" checksum="F0D7B053E3E60952" modified="2021-06-02" version="1">MRRSASTCGWKTPTRRGTSRPSDSKTLILELPDERAVAIVPVPSKLSLKAAGGPRGAQSGHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA49</accession>
    <name>A0A7U8YA49_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Conserved membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03872</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NTE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900661.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA49"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="11">
        <location>
            <begin position="25"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="515"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="12">
        <location>
            <begin position="790"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="8">
        <location>
            <begin position="794"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="8">
        <location>
            <begin position="821"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="8">
        <location>
            <begin position="937"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="823"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD14974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1048" mass="110199" checksum="9F19B809B6D5A49D" modified="2021-06-02" version="1">MHISLHGGKGFANLTRRRRPSSASVLLVAGFGAFLAFLDSTIVNIAFPDIQRSFPSYDIGSLSWILNGYNIVFAAFMVAAGRLADLLGRRRTFLSGVLVFTIASGLCAVAGSVEQLVAFRVLQGIGAAILVPASLALVVEGFDAARRAHAIGLWGAAAAIAAGLGPPIGGLLVEWAGWRWVLLVNVPLGIVAAIATKRMLVESRASGRRRMPDLRGALLLAVTLGLVTLGLVKGPDWGWLSVATVGSFLASVLTSVGFVHSSRSHPAPLVEPALLRSRSFVAGNLLTLVAAAGFYCYGLTHVLYLNYVWHYSLLKAGFAIAPAAVVAAVVAAALGRVAGRHGHRVIVLVGALVWAGSLVWYLQRVGSEPDFLRVWLPGQLLQGIGVGATLPVLSSAALAEVAKGGSYATSSAVVSTTRQLGAVLGVAVMVILIGKPEHGTAEEALRRGWAMAAICFIAVAVAAAVLGRTNRNPVQMPAPEPAIAPRLEPPIPQPAAAPIEHWAAGDADPLGNLPLFAGLDAATLAQLGEHVEDVELEAGCYLFHEGDPSDSLYVIRTGRVQVLQDSIVLKELGRGEVLGELGLLIDAPRSATVRALRDTKLVRLTKAQFDEIADHGALAALVKVLATRLREAPPPATDSTSPEVVVSVIGVSGDAPVPAVAAGLLTALSARLRAVDPGRVDRDGLDRAERVADKVVLHAAVEDAGWRDFCLRVADRIVLVAGDPNPQAARLPARARGADLVLAGPAASREHRRQWEELITPRSVHVVHYRRILENVRPLAARIAGRSIGLVLGGGGARGFAHLGVLDELERVGVTIDRFAGTSMGAVIAVFGACGMDAATADAYAYEYFIRHNPLSDYAFPVRGLVRGRRTLTLLEAAFGDRLVEELPKEFRCVSVDLLARRPVVHRRGRLVDVIGCSLRLPGIYPPQVYNGRLHVDGGVLDNLPVSTRASPDGPLIAVSIGLGGGGPGSARQDGSPKVPGIGDTLMRTMTIGSQRGADAALSLAQVVIRPDTGAVGLLEFHQIDAAREAGRVAAREAMPHIMALLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA74</accession>
    <name>A0A7U8YA74_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Propionyl-CoA carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417136.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA74"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="3">
        <location>
            <begin position="25"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="4">
        <location>
            <begin position="295"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="548" mass="59354" checksum="A1C4C382ABBE3FAE" modified="2021-06-02" version="1">MTSVTDRSAHSAERSTEHTIDIHTTAGKLAELHKRREESLHPVGEDAVEKVHAKGKLTARERIYALLDEDSFVELDALAKHRSTNFNLGEKRPLGDGVVTGYGTIDGRDVCIFSQDATVFGGSLGEVYGEKIVKVQELAIKTGRPLIGINDGAGARIQEGVVSLGLYSRIFRNNILASGVIPQISLIMGAAAGGHVYSPALTDFVIMVDQTSQMFITGPDVIKTVTGEEVTMEELGGAHTHMAKSGTAHYAASGEQDAFDYVRELLSYLPPNNSTDAPRYQAAAPTGPIEENLTDEDLELDTLIPDSPNQPYDMHEVITRLLDDEFLEIQAGYAQNIVVGFGRIDGRPVGIVANQPTHFAGCLDINASEKAARFVRTCDCFNIPIVMLVDVPGFLPGTDQEYNGIIRRGAKLLYAYGEATVPKITVITRKAYGGAYCVMGSKDMGCDVNLAWPTAQIAVMGASGAVGFVYRQQLAEAAANGEDIDKLRLRLQQEYEDTLVNPYVAAERGYVDAVIPPSHTRGYIGTALRLLERKIAQLPPKKHGNVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAC1</accession>
    <name>A0A7U8YAC1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="70" mass="7782" checksum="4E1983D0ACF35725" modified="2021-06-02" version="1">MADPRLPRSRRWLLNLVITRGTPPRLEGCRPASRGLTLALMTDSKPSAWQLLSANSKHNSGGLNWPFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF14</accession>
    <name>A0A7U8TF14_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">O-succinylbenzoic acid-CoA ligase menE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF14"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="271"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="362" mass="36619" checksum="12BC19439BCCACB4" modified="2021-06-02" version="1">MLGGSDPALVAVPTQHESLLGALRVGEQIDDDVALVVTTSGTTGPPKGAMLTAAALTASASAAHDRLGGPGSWLLAVPPYHIAGLAVLVRSVIAGSVPVELNVSAGFDVTELPNAIKRLGSGRRYTSLVAAQLAKALTDPAATAALAELDAVLIGGGPAPRPILDAAAAAGITVVRTYGMSETSGGCVYDGVPLDGVRLRVLAGGRIAIGGATLAKGYRNPVSPDPFAEPGWFHTDDLGALESGDSGVLTVLGRADEAISTGGFTVLPQPVEAALGTHPAVRDCAVFGLADDRLGQRVVAAIVVGDGCPPPTLEALRAHVARTLDVTAAPRELHVVNVLPRRGIGKVDRAALVRRFAGEADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF57</accession>
    <name>A0A7U8TF57_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403017.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016791">
        <property type="entry name" value="Polyketide_synth_GrhN/RubW_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021513">
        <property type="entry name" value="GrhN_RubW_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="163" mass="18035" checksum="23C55B9D8A6135F7" modified="2021-06-02" version="1">MTDQSYAVDIAHPPAALLRLVNPILRSLLHTPLAGPLRTQLMVVSFTGRKTGRHFSIPLSAHVIDNDLYALTEAGWKHNFSDGAAAQVVYDGKTTAMRGELIRDRAVVSELFLRAAQAYGVKRGQRMLGLSFRDRRIPTLEEFAEAVDRLKLVAIRLTPADNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF58</accession>
    <name>A0A7U8TF58_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898511.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF58"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027798">
        <property type="entry name" value="Ub_Mut7C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14451">
        <property type="entry name" value="Ub-Mut7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ub-Mut7C" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="97"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="252" mass="28540" checksum="AA2487A2BD5B980C" modified="2021-06-02" version="1">MVGYVDVRAYAELNEFVELQARGLTVRRPFRSHQTVKDVLEAMGIPHTEVDLILVNGDPADFSYRPVAGDRIAAYPMFEALDIGSTARLRPAPLRNPRFVVDVNLGQLARLLRLLGFDTRWSSAADDPTLADISLGEQRILLTRDRGLLKRRAITHGLFVHSQHPEEQALEVLRRLDLNGRLAPLSRCLRCNGELAAVSKDEVIGQLEPLTRRYYESFSRCFGCGRIYWPGSHHARLVRLVERLRDQLTTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF91</accession>
    <name>A0A7U8TF91_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="385" mass="40142" checksum="F0E545B31C536345" modified="2021-06-02" version="1">MAGDRGADPGPANVTPGADDHAQHASPTVLCPQGHVNAWDYRFCERCGSPIGVVPWPSEESGTRQTAPARSFVPLVVLAATLLVVAVVVTAVGYAVTRPARNDREEPSSARGAATTGVPFAQAEAASCPDDPVLEAESIDLTSDGLAVSAAFMSACAGGDVESNSALEVTVADGRRDVAAGSFDFSADPLRIEPGVPARRTLVFPPGMYWRTPDMLSGAPALAATRKGRSDRSAARGGSARTTMVAAASAAPAYGSINAVAGAVLVELRDSDFPYVRVGIANRWVPQVSSKRVGLVAAGKTWTSADILRDHLALRQRFGGARLVWSGHWTTFSGPDFWVTVVGPAQPTAAEANRWCDSNGFGADDCFAKFISTLVGAKGTTVYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF94</accession>
    <name>A0A7U8TF94_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dolichyl-phosphate sugar synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF94"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="210" mass="22404" checksum="ECA006F121AC9ED0" modified="2021-06-02" version="1">MLPCLNEEESLPAVLAAIPAGYRALVVDNNSTDDTATVAARHGAQVVVEPRPGYGSAVHAGVLAATTPIVAVIDADGSMDAGDLPKLVAELDKGADLVTGRRRPVAGLHWPWVARVGTVVMSWRLRTRHRLPVHDIAPMRVARREALLDLGVVDRRSGYPLELLVRAAAAGWRVVELDVSYGPRTGGKSKVSGSLRGSIIAILDFWKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF96</accession>
    <name>A0A7U8TF96_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein TBLG_02772</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403277.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF96"/>
    <dbReference type="GeneID" id="45424594"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="158" mass="17481" checksum="F4AD9150CE3C7326" modified="2021-06-02" version="1">MALSADIVGMHYRYPDHYEVEREKIREYAVAVQNDDAWYFEEDGAAELGYKGLLAPLTFICVFGYKAQAAFFKHANIATAEAQIVQVDQVLKFEKPIVAGDKLYCDVYVDSVREAHGTQIIVTKNIVTNEEGDLVQETYTTLAGRAGEDGEGFSDGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFD0</accession>
    <name>A0A7U8TFD0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase echA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="297" mass="31534" checksum="639BC0384A98444B" modified="2021-06-02" version="1">MTHAIRPVDFDNLKTMTYEVTGRIARITFNRPEKGNAIIADTPLELSALVERADLDPGVHVILVSGRGEGFCAGFDLSAYAEGSSSTGGGGAYQGTVLDGKTQAVNHLPNQPWDPMIDYQMMSRFVRGFASLMHADKPTVVKIHGYCVAGGTDIALHADQVIAAADAKIGYPPTRVWGVPAAGLWAHRLGDQRAKRLLFTGDCITGAQAAEWGLAVEAPEPADLDERTERLVARIAALPVNQLIMVKLALNSALLQQGVATSRMVSTVIDDAAPPHTEWHALSTSRSSTAPGCGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFG0</accession>
    <name>A0A7U8TFG0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsE</name>
        <name evidence="12" type="ORF">TBLG_02865</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="function">
        <text evidence="7">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403680.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFG0"/>
    <dbReference type="GeneID" id="45424686"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="11">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="220" mass="22888" checksum="F40C104B499F7498" modified="2021-06-02" version="1">MAEQPAGQAGTTDNRDARGDREGRRRDSGRGSRERDGEKSNYLERVVAINRVSKVVKGGRRFSFTALVIVGDGNGMVGVGYGKAKEVPAAIAKGVEEARKSFFRVPLIGGTITHPVQGEAAAGVVLLRPASPGTGVIAGGAARAVLECAGVHDILAKSLGSDNAINVVHATVAALKLLQRPEEVAARRGLPIEDVAPAGMLKARRKSEALAASVLPDRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFG1</accession>
    <name>A0A7U8TFG1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsH</name>
        <name evidence="7" type="ORF">TBLG_02862</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403669.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFG1"/>
    <dbReference type="GeneID" id="45424683"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="132" mass="14412" checksum="36A711E2FD00C851" modified="2021-06-02" version="1">MTMTDPIADFLTRLRNANSAYHDEVSLPHSKLKANIAQILKNEGYISDFRTEDARVGKSLVIQLKYGPSRERSIAGLRRVSKPGLRVYAKSTNLPRVLGGLGVAIISTSSGLLTDRQAARQGVGGEVLAYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFG4</accession>
    <name>A0A7U8TFG4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplO</name>
        <name evidence="10" type="ORF">TBLG_02867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFG4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="9">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="146" mass="15521" checksum="7AF627EA25FC2085" modified="2021-06-02" version="1">MTLKLHDLRPARGSKTARTRVGRGDGSKGKTAGRGTKGTRARKQVPVTFEGGQMPIHMRLPKLKGFRNRFRTEYEIVNVGDINRLFPQGGAVGVDDLVAKGAVRKNALVKVLGDGKLTAKVDVSAHKFSGSARAKITAAGGSATEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFH4</accession>
    <name>A0A7U8TFH4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02884</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901008.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="175" mass="19452" checksum="CD8EB84AE02A6723" modified="2021-06-02" version="1">MLPKNTRPTSETAEEFWDNSLWCSWGDRETGYTRTVTVSICQVADGEREAEGVRDMMRLECPAGLDLRTPNPEAYEITGQRPGEFVFVLGYLGHVRAIVGNCYIEIMPMGTRVELSKLADVALDIGRSVGCSAYENDFTLPDIPTQWRNQPLGWYTQGLAPYLPGLSDPKDAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFJ3</accession>
    <name>A0A7U8TFJ3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsZ</name>
        <name evidence="5" type="synonym">rpsN</name>
        <name evidence="6" type="ORF">TBLG_02861</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403667.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFJ3"/>
    <dbReference type="GeneID" id="45424682"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="61" mass="6825" checksum="6E88B1BE54107AD6" modified="2021-06-02" version="1">MAKKALVNKAAGKPRFAVRAYTRCSKCGRPRAVYRKFGLCRICLREMAHAGELPGVQKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFN6</accession>
    <name>A0A7U8TFN6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02975</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010095">
        <property type="entry name" value="Transposase_IS605_OrfB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="OrfB_Zn_ribbon" evidence="5">
        <location>
            <begin position="4"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="96" mass="10098" checksum="74C70316EB26ABAE" modified="2021-06-02" version="1">MGPSSKTCHACRHVQDIGWDEKWQCDGCSITHQRDDNAAINLARYEEPPSVVGPVGAAVKRGADRKTGPGPAGGREARKGTGHPAGEQPRDGVLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFQ7</accession>
    <name>A0A7U8TFQ7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine synthase A cysK2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404395.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFQ7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901607">
        <property type="term" value="P:alpha-amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="3">
        <location>
            <begin position="31"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="372" mass="40148" checksum="226282B741603B6A" modified="2021-06-02" version="1">MRSRQTRDRYRLLPEGYQVTPGRNRHPGTMVGNTPVLWIPELSGTSDPDRGFWAKLEGFNPGGMKDRPALYMVECARARGDIAPGAAIVESTSGTLGLGLALAGKVYRHPVTLVTDPGLEPIIARMLTAYGAGVDMVTQPHPVGGWQQARKDRVAQLMAEYPGAWNPNQYGNPDNVGAYRSLALELVAQLGRIDVLVCSVGTGGHSAGVARVLREFNPDMRLIGVDTIGSTIFGQPASNRLMRGLGSSIYPRNVDYRAFDEVHWVAPPEAVWACRSLAATHYASGGWSVGAVALVAGWAARNLPADTTIAAVFPDGPQRYFDTIYNDAYCNEHELLGGQPPTEPDEIASPLDAVVTRWTRSTTVIDPTQVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFQ8</accession>
    <name>A0A7U8TFQ8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404420.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFQ8"/>
    <dbReference type="GeneID" id="45424824"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="27"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="397" mass="42209" checksum="2667A0F603D1C4F5" modified="2021-06-02" version="1">MTVSRLRPYATTVFAEMSALATRIGAVNLGQGFPDEDGPPKMLQAAQDAIAGGVNQYPPGPGSAPLRRAIAAQRRRHFGVDYDPETEVLVTVGATEAIAAAVLGLVEPGSEVLLIEPFYDSYSPVVAMAGAHRVTVPLVPDGRGFALDADALRRAVTPRTRALIINSPHNPTGAVLSATELAAIAEIAVAANLVVITDEVYEHLVFDHARHLPLAGFDGMAERTITISSAAKMFNCTGWKIGWACGPAELIAGVRAAKQYLSYVGGAPFQPAVALALDTEDAWVAALRNSLRARRDRLAAGLTEIGFAVHDSYGTYFLCADPRPLGYDDSTEFCAALPEKVGVAAIPMSAFCDPAAGQASQQADVWNHLVRFTFCKRDDTLDEAIRRLSVLAERPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFV2</accession>
    <name>A0A7U8TFV2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA thiolase fadA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404423.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFV2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="281"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="403" mass="42384" checksum="84022FC43EB2BA94" modified="2021-06-02" version="1">MSEEAFIYEAIRTPRGKQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVSPVGDQGGDIARAAVLASGMPVTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVESMSRVPMGSDGGAMGLDPATNYDVMFVPQGIGADLIATIEGFSREDVDAYALRSQQKAAEAWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAALGGFDDVALQKYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVATATSGADPVIMLTGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHPLGATGAMILGTMVDELERRNARRALITLCIGGGMGVATIIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG17</accession>
    <name>A0A7U8TG17_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="68" mass="7239" checksum="44C008B9D200CA96" modified="2021-06-02" version="1">MIGKGRLQRAFSIVAALICARKLIPKRKAHHGCAHAQKVAREHPKPALAVEGPAGRVRAEHTGRAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG28</accession>
    <name>A0A7U8TG28_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405164.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG28"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="333" mass="35626" checksum="F66AFCDF3247331D" modified="2021-06-02" version="1">MDGIAELTGARVEDLAGMDVFQGCPAEGLVSLAASVQPLRAAAGQVLLRQGEPAVSFLLISSGSAEVSHVGDDGVAIIARALPGMIVGEIALLRDSPRSATVTTIEPLTGWTGGRGAFATMVHIPGVGERLLRTARQRLAAFVSPIPVRLADGTQLMLRPVLPGDRERTVHGHIQFSGETLYRRFMSARVPSPALMHYLSEVDYVDHFVWVVTDGSDPVADARFVRDETDPTVAEIAFTVADAYQGRGIGSFLIGALSVAARVDGVERFAARMLSDNVPMRTIMDRYGAVWQREDVGVITTMIDVPGPGELSLGREMVDQINRVARQVIEAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG37</accession>
    <name>A0A7U8TG37_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405180.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030522010" evidence="1">
        <location>
            <begin position="32"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="567" mass="61298" checksum="978B464784CB72D1" modified="2021-06-02" version="1">MVLRSRKSTLGVVVCLALVLGGPLNGCSSSASHRGPLNAMGSPAIPSTAQEIPNPLRGQYEDLMEPLFPQGNPAQQRYPPWPASYDASLRVSWRQLQPTDPRTLPPDAPDDRKYDFSVIDNALTRLADRGMRLTLRVYAYSSCCKASYPDGTNIAIPDWERAIASTNTSYPGPATDPSTGVVQVVPNFNDSTYLNDFAQLLAALGRRYDGDERLSVFEFSGYGDFSENHVAYLRDTLGAPGPGPDESVATLGYYSQFRDQNITTASIKQLIAANVSAFPHTQLVTSPANPEIVRELFADEVTNKLAAPVGVRSDCLGVDAPLPAWAESSTSHYVQTKDPVVAALRQRLATAPVITEWCELPTGSSPRAYYEKGLRDVIRYHVSMTSSVNFPDQTATSPMDPALYLVWAQANAAAGYRYSVEAQPGSQALAGKVATISVTWTNYGAAAATEKWVPGYRLVDSTGQVVRTLPAAVDLKTLVSDQRGDRSSDQPTPASVAETVRVDLSGLPAGHYTLRAAIDWQQHKPNGSHVVNYPPMLLSRDGRDDSGFYPVATLDIPRDAQTAVNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGA3</accession>
    <name>A0A7U8TGA3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase (Decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03295</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="3">
        <location>
            <begin position="186"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="340" mass="36344" checksum="E4293265E97E6D50" modified="2021-06-02" version="1">MQLGMIGLGRMGANIVRRLAKGGHDCVVYDHDPDAVKAMAGEDRTTGVASLRELSQRLSAPRVVWVMVPAGNITTAVIEELANTLEAGDIVIDGGNTYYRDDLRHEKLLFKKGIHLLDCGTSGGVWGRERGYCLMIGGDGDAFARAEPIFATVAPGVAAAPRTPGRDGEVAPSEQGYLHCGPCGSGHFVKMVHNGIEYGMMASLAEGLNVLRNADVGTRVQHGDAETAPLPNPECYQYDFDIPEVAEVWRRGSVIGSWLLDLTAIALRESPDLAEFSGRVSDSGEGRWTAIAAIDEGVPAPVLTTALQSRFASRDLDDFANKALSAMRKQFGGHAEKPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGA8</accession>
    <name>A0A7U8TGA8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-[acyl-carrier protein] desaturase desA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03268</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="275" mass="31359" checksum="9A57C6279AC44116" modified="2021-06-02" version="1">MAQKPVADALTLELEPVVEANMTRHLDTEDIWFAHDYVPFDQGENFAFLGGRDWDPSQSTLPRTITDACQILLILKDNLAGHHRELVEHFILEDWWGRWLGRWTAEEHLHAIALREYLVVTREVDPVANEDVRVQHVMKGYRAEKYTQVETLVYMAFYERCGAVFCRNLAAQIEEPILAGLIDRIARDEVRHEEFFANLVTHCLDYTRDETIAAIAARAADLDVLGADIEAYRDKLQNVADAGIFGKPQLRQLISDRITAWGLAGEPSLKQFVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGD1</accession>
    <name>A0A7U8TGD1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03334</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyltransferase 87 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018584">
        <property type="entry name" value="GT87"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09594">
        <property type="entry name" value="GT87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="416" mass="45534" checksum="5BE821E083159B56" modified="2021-06-02" version="1">SQADRHHLIPPSGCQAAWTSPPARETRAAVLLLVLSVGARLAWTYLAPNGANFVDLHVYVSGAASLDHPGTLYGYVYADQTPDFPLPFTYPPFAAVVFYPLHLVPFGLIALLWQVVTMAALYGAVRISQRLMGGTAETGHFAAMLWTAIAIWIEPLRSTFDYGQINVLLMLAALWAVYTPRWWLSGLLVGVASGVKLTPAITAVYLVGVRRLHAAAFSVVVFLATVGVSLLVVGDEARYYFTDLLGDAGRVGPIATSFNQSWRGAISRILGHDAGFGPLVLAAIASTAVLAILAWRALDRSDRLGKLLVVELFGLLLSPISWTHHWVWLVPLMIWLIDGPARERPGARILGWGWLVLTIVGVPWLLSFAQPSIWQIGRPWYLAWAGLVYVVATLATLGWIAASERYVRIRPRRMAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGE1</accession>
    <name>A0A7U8TGE1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012545">
        <property type="entry name" value="DUF1697"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36439">
        <property type="entry name" value="PTHR36439"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08002">
        <property type="entry name" value="DUF1697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008502">
        <property type="entry name" value="UCP008502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="198" mass="21293" checksum="6327A27E584FA637" modified="2021-06-02" version="1">MRAMPRAYVAVASFSGGLVQSGMAKFAAFLRGVNVGGVNLKMAEVATALTDAGFCNVRTILASGNVLLESTCGAAEVREKTEATLRERFGYDAWALIYDVDTVRTIVAAYPFECELEGYQSYVTFVADAAILDELSALADTAGPDENISRGPDPLGVLYWQVPKGSTLDSTIGQTMGKKRYKSSTTTRNLRTLAKVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGG1</accession>
    <name>A0A7U8TGG1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03379</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGG1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="194" mass="19906" checksum="0A57FED5D8CE48D6" modified="2021-06-02" version="1">MLLAYVLITKGEFGAAASMLEPAAATLERTGYSWGPLSLMLLATAIAQQGHIAESAKTLQRAEARHGTKSALFAPELGLARAWTRAAAQDMTGAIAAAREAARTAERAGQAAVALCAWHNAVRLGDIRAVDPVTRLAAEIDCTVGNILVKHARGLADGDAAELTAVAEELAGIGMAAAAADATKAAARLGPQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGG4</accession>
    <name>A0A7U8TGG4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyketide beta-ketoacyl synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2005"/>
            <end position="2081"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="6">
        <location>
            <position position="2040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="2085" mass="220504" checksum="7A3322101776E2E2" modified="2021-06-02" version="1">MRTATATSVAVIGMACRLPGGIDSPQRLWEALLRGDDLVGEIPADRWDANVYYDPEPGVPGRSVSRWGAFLDDVGGFDCDFFGLTEREATAIDPQHRLLLEVSWEAIEHAGVDPATLAESQTGVFVGLTHGDYELLSADCGAAEGPYGFTGTSNSFASGRVAYTLGLHGPAVTVDTACSSGLTAVHQACRSLDDGESDLALAGGVVVTLEPRKSVSGSLQGMLSPTGRCHAFDEAADGFVSGEGCVVLLLKRLPDAVRDGDRVLAIVRGTAANQDGRTVNIAAPSAQAQIAVYQQALVAAGVEASTVGMVEAHGTGTPVGDPVEYASLAAVYGTEGPCALTSVKTNFGHLQSASGPLGLMKTILALRHGVVPQNLHFCRLPDQLAEIDTELFVPQANTSWPDNTGQPRRAAVSSYGMSGTNVHAILEQAPVSEPAASGPELTPEAGGLALFPVSATSAEQLHVTAARLADWVDQNGNAGSRVSMRDLGYTLSCRRAHRPVRTVVTASSFDELSAALRDVAGDQIPYQPAVGHDDRGPVWVFSGQGSQWPGMGTELLVAEPVFAATVAAMEPVIARESGFSVTEAMSAPQTVSGIDRVQPTIFAVQVALAAALKSYGVRPGAIIGHSLGEAAAAVVAGALSLHDGLRVICRRSRLMSRIAGSGAMASVELPGQQVLSELAIRGISDVVLSVVASPTSTVVGGATQSIRDLVAAWEQQDVLAREVAVDVASHTPQVDPILDELLEVLAEVDPTAPEIPYYSATLWDPRERPSFTGEYWVENLRYTVRFAAAVQAALKDGYRVFGELAPHPLLTYAVEQNAASLDMPIATLAAMRRGEQLPFGLRGFVADVHNAGAKVDFSVQYPDGRLVDAPLPSWTHRTLMLSREDSHRSHTGAVQAVHPLLGAHVHLLEEPERHVWQAAVGTGAHPWLGDHRIHNVAAFPGAAYCEMALAAARTTLGELSEVRDIKFEQTLLLDEQTVVSSAATIAAPGILQFAVESHQEGEPARRASAMLHALEEMPQPPGYDTNALTAAHESSMSGEELRKMFNSLGIQYGPAFSGLVAVHTARGDVTTVLAEVALPGAIRSQQSAYASHPALLDACFQSVLVHPEVQKATVGGLMLPVGVRRLRNYHSTRSAHYCLARVTSSSRAGECEADLDVFDQAGTVLLTVEGLRLAAGISEHERANRVFDERLLTIEWERGELPEVPQIDAGSWLLLSASEADPLTAQLADALNAVGAQSTSVASASDVAQLRSLLGGRLTGVVVVTGPPTGGLTQCGRDYVSQLVGIARELAELPGEPPRLFVVTRSAASVLPSDLANLEQAGLRGLMRVIDSEHPHLGATAIDVDNDETVAALVASQLQSGSQEDETAWRNGIWYTARLRPGPLRPAERRTAVVEYRRDGMRLQIRTPGDLESLEFVTFDRVAPGPGEIEVAVTASSVNFADVLVAFGRYPTFEGYRQQLGIDFAGVVTAVGPDVTEHRIGDHVGGMSANGCWSTFVRCDARLAVTLPPELPVAAAAAVPTASATAWYALHDLARICSDDKVLIHSGTGGVGQAAIAIARAAGCEIFATAGSAQRRQLLHDMGVEHVYDSRSTEFAEQIRGDTDGYGVDVVLNSLPGAAQRAGIELLAFGGRFVEIGKRDIYGDTRLGLFPFRRNLSLYAVDLALLTHSHPHTVRRLLKTVYQHTVEGTLPVPQTTHYPIHDAAVAIRLVGGAGHTGKVVLDVPRTGEGVAVVPPEQVRTSRPDGAYLVTGGLGGLGLFLAGELAAAGCGRIVLNSRSTPSPHATRVIERLRAAGADIQVECGDIADAATAHRVVAVATASGLPVRGVLHAAAVVEDATLANVTDELIDRCWAPKVHGAWNIHRATAAQPLEWFCLFSSAAALVGSPGQGAYAAANSWLDAFAHWRRAQGLPATSIAWGAWAEIGRATALAEGTGAAIAPAEGARAFQTLLRYGRAYSGYAPIMGTPWLTAFAQRSRFAEAFHATGQNQPATGKFLAELGSLPREEWPRTVRRLVSDQISLLLRRTIDPDRPLSDYGLDSLGNLELRTRIETETGIRVSPTKITTVRGLAEHVCDELAAAQSAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGP7</accession>
    <name>A0A7U8TGP7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,4-glucan:maltose-1-phosphate maltosyltransferase</fullName>
            <shortName evidence="3">GMPMT</shortName>
            <ecNumber evidence="3">2.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(1-&gt;4)-alpha-D-glucan:maltose-1-phosphate alpha-D-maltosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">glgE</name>
        <name evidence="6" type="ORF">TBLG_03512</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1-&gt;4)-glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + alpha-maltose 1-phosphate = [(1-&gt;4)-alpha-D-glucosyl](n+2) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:42692"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:10183"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="EC" id="2.4.99.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.16" evidence="3"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406897.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGP7"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02124">
        <property type="entry name" value="GlgE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026585">
        <property type="entry name" value="GlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021828">
        <property type="entry name" value="GlgE_dom_N/S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11896">
        <property type="entry name" value="DUF3416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="5">
        <location>
            <begin position="232"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="286"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Maltose 1-phosphate binding" evidence="3">
        <location>
            <begin position="557"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="447"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>alpha-maltose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="701" mass="78640" checksum="EE637BA1DA7D694F" modified="2021-06-02" version="1">MSGRAIGTETEWWVPGRVEIDDVAPVVSCGVYPAKAVVGEVVPVSAAVWREGHEAVAATLVVRYLGVRYPHLTDRPRARVLPTPSEPQQRVKPLLIPMTSGQEPFVFHGQFTPDRVGLWTFRVDGWGDPIHTWRHGLIAKLDAGQGETELSNDLLVGAVLLERAATGVPRGLRDPLLAAAAALRTPGDPVTRTALALTPEIEELLADYPLRDLVTRGEQFGVWVDRPLARFGAWYEMFPRSTGGWDDDGNPVHGTFATAAAELPRIAGMGFDVVYLPPIHPIGKVHRKGRNNSPTAAPTDVGSPWAIGSDEGGHDTVHPSLGTIDDFDDFVSAARDLGMEVALDLALQCAPDHPWAREHRQWFTELPDGTIAYAENPPKKYQDIYPLNFDNDPEGLYDEVLRVVQHWVNHGVKFFRVDNPHTKPPNFWAWLIAQVKTVDPDVLFLSEAFTPPARQYGLAKLGFTQSYSYFTWRTTKWELTEFGNQIAELADYRRPNLFVNTPDILHAVLQHNGPGMFAIRAVLAATMSPAWGMYCGYELFEHRAVREGSEEYLDSEKYELRPRDFASALDQGRSLQPFITRLNIIRRLHPAFQQLRTIHFHHVDNDALLAYSKFDPATGDCVLVVVTLNAFGPEEATLWLDMAALGMEDYDRFWVRDEITGEEYQWGQANYIRIDPARAVAHIINMPAVPYESRNTLLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGQ0</accession>
    <name>A0A7U8TGQ0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="173" mass="16512" checksum="EA68482FB39EA53F" modified="2021-06-02" version="1">MSFVIAAPETLVRAASDLANIGSTLGAANAAALGPTTELLAAGADEVSAAIASLFAAHGQAYQAVSAQMSAFHAQFVQTFTAGAGAYASAEAAAAAPLEGLLNIVNTPTQLLLGRPLIGNGANGAPGTGQAGGAGGLLYGNGGAGGSGAPGQAGGPGWSRGAIRQRRGGWGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGS2</accession>
    <name>A0A7U8TGS2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGS2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="377" mass="41311" checksum="3C9570D10B3DF52E" modified="2021-06-02" version="1">MVWQREKLLQVNEIGYRDIDAGVPMQRDTLFRIASMTKPVTVAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAYGFSVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYSHAIDVLGVIVSRIEDAPLYQVIDERVLGPAGMTDTGFYVSADAQRRAATMYRLDEQDRLRHDVMGPPHVTPPSFCNAGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHSFLGAPFWVGRGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLYLIQHCPDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGT8</accession>
    <name>A0A7U8TGT8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450 132 cyp132</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407260.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGT8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="461" mass="52186" checksum="EA176E6EAEA05791" modified="2021-06-02" version="1">MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGSDITRFRCAGRRFVSISHPDYVDHVLHEARLKYVKSDEYGPIRATAGLNLLTDEGDSWARHRGALNSTFARRHLRGLVGLMIDPIADVTAALVPGAQFDMHQSMVETTLRVVANALFSQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLREMQEITLTLDRAINSVIDRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGHETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRYFSSVWIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPTDRPRCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRPKHGVHVIGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGV4</accession>
    <name>A0A7U8TGV4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aminoglycosides/tetracycline-transport membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407310.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGV4"/>
    <dbReference type="GeneID" id="45425388"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="408"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="475"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD13014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="518" mass="54689" checksum="3D211E3F5A3F77D0" modified="2021-06-02" version="1">MRAGRRVAISAGSLAVLLGALDTYVVVTIMRDIMNSVGIPINQLHRITWIVTMYLLGYIAAMPLLGRASDRFGRKLMLQVSLAGFIIGSVVTALAGHFGDFHMLIAGRTIQGVASGALLPITLALGADLWSQRNRAGVLGGIGAAQELGSVLGPLYGIFIVWLLHDWRDVFWINVPLTAIAMVMIHFSLPSHDRSTEPERVDLVGGLLLALALGLAVIGLYNPNPDGKHVLPDYGAPLLVGALVAAVAFFGWERFARTRLIDPAGVHFRPFLSALGASVAAGAALMVTLVDVELFGQGVLQMDQAQAAGMLLWFLIALPIGAVTGGWIATRAGDRAVAFAGLLIAAYGYWLISHWPVDLLADRHNILGLFTVPAMHTDLVVAGLGLGLVIGPLSSATLRVVPSAQHGIASAAVVVARMTGMLIGVAALSAWGLYRFNQILAGLSAAIPPNASLLERAAAIGARYQQAFALMYGEIFTITAIVCVFGAVLGLLISGRKEHADEPEVQEQPTLAPQVEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGV6</accession>
    <name>A0A7U8TGV6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable cell division protein WhiA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">whiA</name>
        <name evidence="8" type="ORF">TBLG_03611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cell division and chromosome segregation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WhiA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901156.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGV6"/>
    <dbReference type="GeneID" id="45425401"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043937">
        <property type="term" value="P:regulation of sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01420">
        <property type="entry name" value="HTH_type_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027434">
        <property type="entry name" value="Homing_endonucl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018478">
        <property type="entry name" value="Sporu_reg_WhiA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003802">
        <property type="entry name" value="Sporulation_regulator_WhiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023054">
        <property type="entry name" value="Sporulation_regulator_WhiA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039518">
        <property type="entry name" value="WhiA_LAGLIDADG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37307">
        <property type="entry name" value="PTHR37307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02650">
        <property type="entry name" value="HTH_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14527">
        <property type="entry name" value="LAGLIDADG_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10298">
        <property type="entry name" value="WhiA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00647">
        <property type="entry name" value="DNA_bind_WhiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WhiA_N" evidence="6">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="LAGLIDADG_WhiA" evidence="7">
        <location>
            <begin position="125"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_WhiA" evidence="5">
        <location>
            <begin position="219"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD13027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="325" mass="34933" checksum="E3EB4C1804267360" modified="2021-06-02" version="1">MTTDVKDELSRLVVKSVSARRAEVTSLLRFAGGLHIVGGRVVVEAELDLGSIARRLRKEIFELYGYTAVVHVLSASGIRKSTRYVLRVANDGEALARQTGLLDMRGRPVRGLPAQVVGGSIDDAEAAWRGAFLAHGSLTEPGRSSALEVSCPGPEAALALVGAARRLGVGAKAREVRGADRVVVRDGEAIGALLTRMGAQDTRLVWEERRLRREVRATANRLANFDDANLRRSARAAVAAAARVERALEILGDTVPEHLASAGKLRVEHRQASLEELGRLADPPMTKDAVAGRIRRLLSMADRKAKVDGIPDTESVVTPDLLEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGV8</accession>
    <name>A0A7U8TGV8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <shortName evidence="7">LS</shortName>
            <shortName evidence="7">Lumazine synthase</shortName>
            <ecNumber evidence="4 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ribH</name>
        <name evidence="8" type="ORF">TBLG_03604</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homopentamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="4 7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGV8"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-amino-6-(D-ribitylamino)uracil binding" evidence="7">
        <location>
            <begin position="75"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="1-deoxy-L-glycero-tetrulose 4-phosphate binding" evidence="7">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD13020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="154" mass="15901" checksum="B10283E900683696" modified="2021-06-02" version="1">MPDLPSLDASGVRLAIVASSWHGKICDALLDGARKVAAGCGLDDPTVVRVLGAIEIPVVAQELARNHDAVVALGVVIRGQTPHFDYVCDAVTQGLTRVSLDSSTPIANGVLTTNTEEQALDRAGLPTSAEDKGAQATVAALATALTLRELRAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGW2</accession>
    <name>A0A7U8TGW2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03613</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="304"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD13029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="458" mass="50004" checksum="058A7918345EBF07" modified="2021-06-02" version="1">MKRLSSVDAAFWSAETAGWHMHVGALAICDPSDAPEYSFQRLRFVFERLPEIPQLRWRVTGAPLGLDRPWFVEDEELDIDFHIRRIGVPAPGGRRELEELVGRLMSYKLDRSRPLWELWVIEGVEGGRIATLTKMHHAIVDGVSGAGLGEILLDITPEPRPPQQETVGFVGFQIPGLERRAIGALINVGIMTPFRIVRLLEQTVRQQIAALGVAGKPARYFEAPKTRFNAPVSPHRRVTGTRVELARAKAVKDAFGVKLNDVVLALVAGAARQYLQKRDELPAKPLIAQIPVSTRSEETKADVGNQVSSMTASLATHIEDPAKRLAAIHESTLSAKEMAKALSAHQIMGLTETTPPGLLQLAARAYTASGLSHNLAPINLVVSNVPGPPFPLYMAGARLDSLVPLGPPVMDVALNITCFSYQDYLDFGLVTTPEVANDIDEMADAIEPALAELERAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH76</accession>
    <name>A0A7U8TH76_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898607.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427949"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="183" mass="20426" checksum="426BC717165687D2" modified="2021-06-02" version="1">MKAATSWMQQQVLATATVVRWRLAWLSKPETWRRRKRRQSQKIRRSVQKQRRSTVWDNQRKTFGVVISPARLTAWIAASALILLTGTELFGTALSWVKLSPIWHVFSFAVDTRPIATLLDYASHPIDPRSYSSVAVTAVGAEATLLAFFFATVGVVASTALNTLRSSPPLLLSSPRLTTGCDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THA8</accession>
    <name>A0A7U8THA8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023978">
        <property type="entry name" value="GMC_oxidoreductase_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03970">
        <property type="entry name" value="Rv0697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="4">
        <location>
            <begin position="9"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_oxred_C" evidence="5">
        <location>
            <begin position="358"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="479" mass="50322" checksum="E59E3E409FED0FAC" modified="2021-06-02" version="1">MTAAVRHSDVLVVGAGSAGSVVAERLSMDSSCVVTVLEAGPGLADPGLLAQTANGLQLPIGAGSPLVERYRTRLTDRPVRHLPIVRGATVGGSGAINGGYFCRGLPSDFDRASIPGWAWSDVLEHFRAIETDLDFETPVHGRSGPIPVRRTHEMTGITESFMAAAEDAGFAWIADLNDVGPEMPSGVGAVPLNIVNGVRTSSAVGYLMPALGRPNLTLLARMRAVRLRFSATTAVGVDAIGPGGPVSLSADRIVLCAGAIQSAHLLMLSGVGEEEVLRSAGVKVLMALPVGMGCSDHPEWVMPTNWAVAVDRPVLEVLLSTHDGIEIRPYTGGFVAMTGDGTAGHRDWPHIGVALMQPRARGRITLVSSDPQIPVRIEHRYDSEPADVAALRQGSALAHELCGAATRIGPAVWATSQHLCGSAPMGTDDDPRAVVDPRCRVRGIENLWVIDGSVLPSITSRGPHATIVMLGHRAAEFVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THE5</accession>
    <name>A0A7U8THE5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved threonine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403446.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021417">
        <property type="entry name" value="DUF3060"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11259">
        <property type="entry name" value="DUF3060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031437617" evidence="2">
        <location>
            <begin position="43"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="165" mass="16586" checksum="82C02C4731DCBCFC" modified="2021-06-02" version="1">MVEKPLRADRATHSRLATFALALAAAALPLAGCSSTANPPAATTTPATATTTTATSGPTAAPTVTTGESTTASIQIGDMLTYGSIGTTATLDCADGKSLNVAGSDNTLTVNGTCETVTVGGANNKIAFDRIDERLVVVGLDNTVTYKNGDPTIDNLGAGNRINKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THK0</accession>
    <name>A0A7U8THK0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898578.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THK0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="275" mass="29064" checksum="DCF83063BCB90D3C" modified="2021-06-02" version="1">MPRFEPHPARRTTVVAGASSGIGAATATELAGRGFPVALGARRMDKLAELVDKIRADGGEAVAFPLDVTDPESVKSFVAQTVEALGEVELLVSSAGDMLPGQLHEVSTEAFAEQVQIHLVGANRLATAVLPAMVARRRGDLIFVGSDVGLRQRPHMGAYGAAKAGLAAMVTNLQMELEGTGVRASIVHPGPTLTGMGWQLSAEQVGPMLADWAKWGQARHNYFLRPSDLARAIAFVAETPRGCVVVNMEIQPEAPLRDAPAHRQKLVLGEEGMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THL4</accession>
    <name>A0A7U8THL4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-keto-acid decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900222.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THL4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="TPP_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PTHR43452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="15"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="210"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="404"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="560" mass="59783" checksum="F0430F720D57B7C4" modified="2021-06-02" version="1">MTPQKSDACSDPVYTVGDYLLDRLAELGVSEIFGVPGDYNLQFLDHIVAHPTIRWVGSANELNAGYAADGYGRLRGMSAVVTTFGVGELSVTNAIAGSYAEHVPVVHIVGGPTKDAQGTRRALHHSLGDGDFEHFLRISREITCAQANLMPATAGREIDRVLSEVREQKRPGYILLSSDVARFPTEPPAAPLPRYPGGTSPRALSLFTKAAIELIADHQLTVLADLLVHRLQAVKELEALLAADVVPHATLMWGKSLLDESSPNFLGIYAGAASAERVRAAIEGAPVLVTAGVVFTDMVSGFFSQRIDPARTIDIGQYQSSVADQVFAPLEMSAALQALATILTGRGISSPPVVPPPAEPPPAMPARDEPLTQQMVWDRVCSALTPGNVVLADQGTSFYGMADHRLPQGVTFIGQPLWGSIGYTLPAAVGAAVAHPDRRTVLLIGDGAAQLTVQELGTFSREGLSPVIVVVNNDGYTVERAIHGETAPYNDIVSWNWTELPSALGVTNHLAFRAQTYGQLDDALTVAAARRDRMVLVEVVLPRLEIPRLLGQLVGSMAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THP3</accession>
    <name>A0A7U8THP3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027787">
        <property type="entry name" value="Alpha/beta-hydrolase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012037">
        <property type="entry name" value="Alpha/beta-hydrolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027788">
        <property type="entry name" value="Alpha/beta-hydrolase_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10081">
        <property type="entry name" value="Abhydrolase_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15420">
        <property type="entry name" value="Abhydrolase_9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007542">
        <property type="entry name" value="UCP007542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9_N" evidence="4">
        <location>
            <begin position="63"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_9" evidence="3">
        <location>
            <begin position="287"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="587" mass="64372" checksum="B6A7555BE792ABD6" modified="2021-06-02" version="1">MTEPAAATTTNASDEPATGAEQAVDTAATPQTPEPQPIRSTWWIRHYTFTGTAMGLVFVWFSMTPSLLPRGPLFQGLVSGICGAFGYGLGVFAVWLVRYMRSHNSSPPPPRWAWPPLIAVGAVGMVGMAVQFHVWQDDVRDLMGVEHLRWYDYPLAAALSLVVLFTLVEIGQFIRWLFRFLVGQVDRIAPFRVSAAIVVVLLVVLTITLLNGVVLKFAMNSMNSTFAAVNNEMNPDSAPPKTPLRSGGPGSLVSWESLGHQGRIFVHSGPTIADLTAFNGTPAVEPIRTYAGLNSADGIMATAELAARELARTGGLRRAVVAVATSTGTGWINEAEASALEYMYNGDTAIVSMQYSFLPSWLSFLVDKENARHAGEALFEAVDKLIRQLPESQRPKLVVFGESLGSFGGEAPFMNLNNILARTDGALFSGPTFNNTVWNSLTANRDAGSPQWLPIYDDGRNVRFVARARDLQRPDAPWGRPWVVYLQHASDPIAWWTPRLLFREPDWLREQRGYDVLPQTRWIPVVTFVQVSADMAVATHVPDGHGHRYVATVADGWAAVLSPPGWTQQKTERLQPLLHANAKPFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THQ5</accession>
    <name>A0A7U8THQ5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="419" mass="44500" checksum="A05034876F152CCE" modified="2021-06-02" version="1">MGARAIFRGFNRPSRVLMINQFGINIGFYMLMPYLADYLAGPLGLAAWAVGLVMGVRNFSQQGMFFVGGTLADRFGYKPLIIAGCLIRTGGFALLVVAQSLPSVLIAAAATGFAGALFNPAVRGYLAAEAGERKIEAFAMFNVFYQSGILLGPLVGLVLLALDFRITVLAAAGVFGLLTVAQLVALPQHRADSEREKTSILQDWRVVVRNRPFLTLAAAMTGCYALSFQIYLALPMQASILMPRNQYLLIAAMFAVSGLVAVGGQLRITRWFAVRWGAERSLVVGATILAASFIPVAVIPNGQRFGVAVAVMALVLSASLLAVASAALFPFEMRAVVALSGDRLVATHYGFYSTIVGVGVLVGNLAIGSLMSAGRRLNTDEIVWGGLILVGIVAVAGLRRLDTFTSGSQNMTGRWAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THR4</accession>
    <name>A0A7U8THR4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaC</name>
        <name evidence="8" type="ORF">TBLG_03016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404544.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THR4"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="7">
        <location>
            <begin position="26"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="122"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="167" mass="17598" checksum="07216D9B18C05E90" modified="2021-06-02" version="1">MARASGASDYRSGELSHQDERGAAHMVDITEKATTKRTAVAAGILRTSAQVVALISTGGLPKGDALATARVAGIMAAKRTSDLIPLCHQLALTGVDVDFTVGQLDIEITATVRSTDRTGVEMEALTAVSVAALTLYDMIKAVDPGALIDDIRVLHKEGGRRGTWTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THT6</accession>
    <name>A0A7U8THT6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03314</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="282" mass="30426" checksum="BAFD4CDDF166D08D" modified="2021-06-02" version="1">MPRDYTAPRWAHAWAGEPRPARWHPANQPAHPDHSNRESPACMSQSTTPYRSSVLAEFRRAITNVAVPHHEPPGIVRRRRVVVGVTLVIGAVMLGFSLRRTPGESSFYWLTLALAAVWIAGALMSGPLHLGGICWRGRNQRPVITGTTVGLLLAGIFGVGAMIVRAIPGAAEPIARVLQFAHQGTLLPILLITLINGIAEEMFFRGALYTALGRRYPVTISTVLYVGATMASANLMLGFAAIFVGTVCALERRASGGVLAPILTHFVWGLIMVFALPPLFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THY6</accession>
    <name>A0A7U8THY6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein lpqX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03404</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406266.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="185" mass="19513" checksum="B461BCA907B2DE38" modified="2021-06-02" version="1">MSRQWHWLAATLLLITTAACSRPGTEEPDCPTKITLPPGATPTTTLDPRCIVRATTTGTADGDAASRWTGTVRIAGFYASICNAVWDGNVSLAGKDELTGKATLILVETSCPGKVVAGELVLKGNVGSDSLAITWAHPELPQRAFDLGAGQGTIRRSGDRAEGTFNSDMGGGTEFFLTWSLTMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI01</accession>
    <name>A0A7U8TI01_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="6 12">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TBLG_03166</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:9517"/>
            <dbReference type="Rhea" id="RHEA-COMP:9527"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="6 12"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901066.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424974"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="GlyclTrfase_39-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="Glyco_trans_39/83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="PTHR10050"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="PMT" evidence="13">
        <location>
            <begin position="100"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_4TMC" evidence="14">
        <location>
            <begin position="311"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD12582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="503" mass="55531" checksum="EB6226AA8F1442C6" modified="2021-06-02" version="1">MVPVVSPGPLVPVADFGPLDRLRGWIVTGLITLLATVTRFLNLGSLTDAGTPIFDEKHYAPQAWQVLNNHGVEDNPGYGLVVHPPVGKQLIAIGEAIFGYNGFGWRFTGALLGVVLVALVVRIVRRISRSTLVGAIAGVLLICDGVSFVTARTALLDGFLTFFVVAAFGALIVDRDQVRERMHIALLAGRSAATVWGPRVGVRWWRFGAGVLLGLACATKWSGVYFVLFFGAMALAFDVAARRQYQVQRPWLGTVRRDVLPSGYALGLIPFAVYLATYAPWFASETAIDRHAVGQAVGRNSVVPLPDAVRSLWHYTAKAFHFHAGLTNSAGNYHPWESKPWTWPMSLRPVLYAIDQQDVAGCGAQSCVKAEMLVGTPAMWWLAVPVLAYAGWRMFVRRDWRYAVVLVGYCAGWLPWFADIDRQMYFFYAATMAPFLVMGISLVLGDILYHPGQGSERRTLGLIVVCCYVALVVTNFAWLYPVLTGLPISQQTWNLEIWLPSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI03</accession>
    <name>A0A7U8TI03_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI03"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="129" mass="14286" checksum="510CDE4D04AB38BF" modified="2021-06-02" version="1">MQQGNPPDAPQLAPAVAWVKKRAGRTPRTVTADRGYGEAAVDQQLTEVGVKNVLIPRKGKPSQDRRAEEHRKAFRRTIKWRTGCEGRISHLKRGYGWDRGRIGGLEGTRTWVGHGVFAHNLVTISALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI45</accession>
    <name>A0A7U8TI45_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase echA9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405716.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI45"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003860">
        <property type="term" value="F:3-hydroxyisobutyryl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045004">
        <property type="entry name" value="ECH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032259">
        <property type="entry name" value="HIBYL-CoA-H"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43176">
        <property type="entry name" value="PTHR43176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16113">
        <property type="entry name" value="ECH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ECH_2" evidence="2">
        <location>
            <begin position="16"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="345" mass="36354" checksum="2D6258EF82685623" modified="2021-06-02" version="1">MTGESHEVLTNVEGGVGFVTLNRPKAINSLNQTMVDLLATVLMSWEHEDAVHAVVLSGAGERGLCAGGDVVAVYHSARKDGVEARRFWRHEYLLNALIGRFAKPYVALMDGIVMGGGVGVSAHANTRVVTDTSKVAMPEVGIGFIPDVGGVYLLSRAPGALGLHAALTGAPFSGADAIALGFADHFVPHGDLDAFTQKIVTGGVESALAAHAVEPPPSTLAAQRDWIDECYAGDSVADIVAALRKQGGEPAVNASDLIASRSPIALSVTLQAVRRAAKLDTLEDVLIQDYRVSSASLRSHDLVEGIRAQLIDKDRNPNWSPATLDAITAADIEAYFEPVDDDLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI61</accession>
    <name>A0A7U8TI61_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycine and proline rich membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405804.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425071"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="293" mass="29874" checksum="2A192D0D8ACBE864" modified="2021-06-02" version="1">MTVPPAGPYGNYPYGPNTYGQDPYWGGQPQGGSYPPAYPPQQYPPGWPAGPYPPGPPPPGPGSKTPWLILAGLAVLGVILLVVILVIGLRGDNKSTTATSPATSAPTSQPFSQQTATGCTPNVSGGVQPIGDSISAGKLSFPTSAAPGWSAFSDDQNPNLIDAVGVGHEVAGADQWMMQAEVAITNFVTTMDVAAQASKLMQCVADGPGYAGSSPTLGPTKTSSITVDGVRAARVDADITIADSSRNVKGDSVTIIAVDTKPVTVFLGATPIGDATSRATVERVIEALKVNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI92</accession>
    <name>A0A7U8TI92_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03584</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031443703" description="PE domain-containing protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="3">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD13000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="295" mass="26728" checksum="2A23375C249BF02E" modified="2021-06-02" version="1">MSFLFAQPEMLGAAATDLASIGSAISTANAAAAAATTRVLAAGADEVSAAVAALFSGHAQTYQALSTQAAAFHQQIVQTLTSTAGAYASAEAANVEQQLLGAINAPTMALLGRPLIGHGADGAPGTGQAGGAGGILYGNGGNGGSGATGQAGGAGGAAGLIGHGGAGGLGGTGASGGAGGAGGWLWGNGGAGGNGGVGVAGDPGGVGGAGGAGGAAGLWGSGGSGGTGGQGGVGGGKSGDCGTGGYRRRLWRWWLAARATASPADTGGRSEPASAQEATAGSAAPAATVAACREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIN1</accession>
    <name>A0A7U8TIN1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="6">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="6">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="6"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406931.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIN1"/>
    <dbReference type="GeneID" id="45425319"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="158"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="204" mass="21016" checksum="879DF0B08A5CCAEE" modified="2021-06-02" version="1">MALVTKLLVASRNRKKLAELRRVLDGAGLSGLTLLSLGDVSPLPETPETGVTFEDNALAKARDAFSATGLASVADDSGLEVAALGGMPGVLSARWSGRYGDDAANTALLLAQLCDVPDERRGAAFVSACALVSGSGEVVVRGEWPGTIAREPRGDGGFGYDPVFVPYGDDRTAAQLSPAEKDAVSHRGRALALLLPALRSLATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIQ3</accession>
    <name>A0A7U8TIQ3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein lprF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03556</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LppX/LprAFG lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16334">
        <property type="entry name" value="LppX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009830">
        <property type="entry name" value="LppX/LprAFG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07161">
        <property type="entry name" value="LppX_LprAFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="261" mass="26880" checksum="B22F2FAD724AE91A" modified="2021-06-02" version="1">MNGLISQACGSHRPRRPSSLGAVAILIAATLFATVVVGCGKKPTTASSPSPGSPSPEAQQILQDSSKATKGLHSVHVVVTVNNLSTLPFESVDADVTNQPQGNGQAVGNAKVRMKPNTPVVATEFLVTNKTMYTKRGGDYVSVGPAEKIYDPGIILDKDRGLGAVVGQVQNPTIQGRDAIDGLATVKVSGTIDAAVIDPIVPQLGKGGGRLPITLWIVDTNASTPAPAANLVRMVIDKDQGNVDITLSNWGAPVTIPNPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR79</accession>
    <name>A0A7U8TR79_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable DNA ligase</fullName>
            <ecNumber evidence="12">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">lig</name>
        <name evidence="16" type="ORF">TBLG_03682</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="12 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="12"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415991.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR79"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 12 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 12 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 12 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="288"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="12">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFD14784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="507" mass="53727" checksum="8D73EB4C08C7149D" modified="2021-06-02" version="1">MLLHDVAITSMDVAATSSRLTKVARIAALLHRAAPDTQLVTIIVSWLSGELPQRHIGVGWAALRSLPPPAPQPALTVTGVDATLSKIGTLSGKGSQAQRAALVAELFSAATEAEQTFLLRLLGGELRQGAKGGIMADAVAQAAGLPAATVQRAAMLGGDLAAAAAAGLSGAALDTFTLRVGRPIGPMLAQTATSVHDALERHGGTTIFEAKLDGARVQIHRANDQVRIYTRSLDDVTARLPEVVEATLALPVRDLVADGEAIALCPDNRPQRFQVTASRFGRSVDVAAARATQPLSVFFFDILHRDGTDLLEAPTTERLAALDALVPARHRVDRLITSDPTDAANFLDATLAAGHEGVMAKAPAARYLAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGGFVMVGKTFKGMTDAMLDWQTTRFHEIAVGPTDGYVVQLRPEQVVEVALDGVQRSSRYPGGLALRFARVVRYRADKDPAEADTIDAVRALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR93</accession>
    <name>A0A7U8TR93_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein E moaE1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899923.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR93"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="147" mass="15920" checksum="22735F7154C1412A" modified="2021-06-02" version="1">MANVVAEGAYPYCRLTDQPLSVDEVLAAVSGPEQGGIVIFVGNVRDHNAGHDVTRLFYEAYPPMVIRTLMSIIGRCEDKAEGVRVAVAHRTGELQIGDAAVVIGASAPHRAEAFDAARMCIELLKQEVPIWKKEFSSTGAEWVGDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRG7</accession>
    <name>A0A7U8TRG7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoenolpyruvate transferase</fullName>
            <ecNumber evidence="3">2.7.8.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EPPG:FO PEP transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fbiA</name>
        <name evidence="4" type="ORF">TBLG_03899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27510"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
            <dbReference type="ChEBI" id="CHEBI:143701"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="2.7.8.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CofD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.28" evidence="3"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417087.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRG7"/>
    <dbReference type="GeneID" id="45427255"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07186">
        <property type="entry name" value="CofD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01257">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010115">
        <property type="entry name" value="FbiA/CofD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43007">
        <property type="entry name" value="PTHR43007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="SSF142338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01819">
        <property type="entry name" value="F420_cofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3 4" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>7,8-didemethyl-8-hydroxy-5-deazariboflavin</name>
            <dbReference type="ChEBI" id="CHEBI:59904"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="331" mass="35335" checksum="4D144F9A17F792C6" modified="2021-06-02" version="1">MKVTVLAGGVGGARFLLGVQQLLGLGQFAANSAHSDADHQLSAVVNVGDDAWIHGLRVCPDLDTCMYTLGGGVDPQRGWGQRDETWHAMQELVRYGVQPDWFELGDRDLATHLVRTQMLQAGYPLSQITEALCDRWQPGARLLPATDDRCETHVVITDPVDESRKAIHFQEWWVRYRAQVPTHSFAFVGAEKSSAATEAIAALADADIIMLAPSNPVVSIGAILAVPGIRAALREATAPIVGYSPIIGEKPLRGMADTCLSVIGVDSTAAAVGRHYGARCATGILDCWLVHDGDHAEIDGVTVRSVPLLMTDPNATAEMVRAGCDLAGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRI3</accession>
    <name>A0A7U8TRI3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-lysine 6-transaminase</fullName>
            <ecNumber evidence="4">2.6.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lysine 6-aminotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03929</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-lysine = (S)-2-amino-6-oxohexanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21200"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="EC" id="2.6.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.36" evidence="4"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045484">
        <property type="term" value="F:L-lysine 6-transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017657">
        <property type="entry name" value="L-lysine_6-transaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03251">
        <property type="entry name" value="LAT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="449" mass="48998" checksum="A5E8143DB2D66B9B" modified="2021-06-02" version="1">MAAVVKSVALAGRPTTPDRVHEVLGRSMLVDGLDIVLDLTRSGGSYLVDAITGRRYLDMFTFVASSALGMNPPALVDDREFHAELMQGALNKPSNSDVYSVAMARFVETFARVLGDPALPHLFFVEGGALAVENALKAAFDWKSRHNQAHGIDPALGTQVLHLRGAFHGRSGYTLSLTNTKPTITARFPKFDWPRIDAPYMRPGLDEPAMAALEAEALRQARAAFETRPHDIACFVAEPIQGEGGDRHFRPEFFAAMRELCDEFDALLIFDEVQTGCGLTGTAWAYQQLDVAPDIVAFGKKTQVCGVMAGRRVDEVADNVFAVPSRLNSTWGGNLTDMVRARRILEVIEAEGLFERAVQHGKYLRARLDELAADFPAVVLDPRGRGLMCAFSLPTTADRDELIRQLWQRAVIVLPAGADTVRFRPPLTVSTAEIDAAIAAVRSALPVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRJ6</accession>
    <name>A0A7U8TRJ6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane alkane 1-monooxygenase alkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family. AlkB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417047.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03512">
        <property type="entry name" value="Alkane-hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033885">
        <property type="entry name" value="AlkB/XylM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38674">
        <property type="entry name" value="PTHR38674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="FA_desaturase" evidence="9">
        <location>
            <begin position="138"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD14992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="416" mass="47014" checksum="720B8968ADE3598D" modified="2021-06-02" version="1">MTTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLPLIWGMNQLGWHAAAQVPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVTDRLENDKYYRYCTYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAGKLGVALSVGVLGGVGINTAHEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRVSTPEDPASARFGETLWEFLPRSVIGGLRSAVHLEAQRLRRLGVSPWNPMTYLRNDVLNAWLMSVVLWGGLIAVFGPALIPFVIIQAVFGFSLLEAVNYLEHYGLLRQKSANGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHANPTRRYQTLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDITRVNLHPRVREKALARYGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRM6</accession>
    <name>A0A7U8TRM6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">guaB</name>
        <name evidence="16" type="ORF">TBLG_03989</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900682.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRM6"/>
    <dbReference type="GeneID" id="45427407"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="189"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="374"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="397"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="421"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="334"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="513"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFD15091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="529" mass="54867" checksum="689A7C7C53993C0A" modified="2021-06-02" version="1">MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRQ4</accession>
    <name>A0A7U8TRQ4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417961.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRQ4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010976">
        <property type="entry name" value="B-phosphoglucomutase_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02009">
        <property type="entry name" value="PGMB-YQAB-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="262" mass="28228" checksum="C8CCD1502EB5B87B" modified="2021-06-02" version="1">MANWYRPNYPEVRSRVLGLPEKVRACLFDLDGVLTDTASLHTKAWKAMFDAYLAERAERTGEKFVPFDPAADYHTYVDGKKREDGVRSFLSSRAIEIPDGSPDDPGAAETVYGLGNRKNDMLHKLLRDDGAQVFDGSRRYLEAVTAAGLGVAVVSSSANTRDVLATTGLDRFVQQRVDGVTLREEHIAGKPAPDSFLRAAELLGVTPDAAAVFEDALSGVAAGRAGNFAVVVGINRTGRAAQAAQLRRHGADVVVTDLAELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRQ6</accession>
    <name>A0A7U8TRQ6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417984.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRQ6"/>
    <dbReference type="GeneID" id="45427401"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="188" mass="20609" checksum="7B226876C5A43630" modified="2021-06-02" version="1">MTTRPATDRRKMPTGREEVAAAILQAATDLFAERGPAATSIRDIAARSKVNHGLVFRHFGTKDQLVGAVLDHLGTKLTRLLHSEAPADIIERALDRHGRVLARALLDGYPVGQLQQRFPNVAELLDAVRPRYDSDLGARLAVAHALALQFGWRLFAPMLRSATGIDELTGDELRLSVNDAVARILEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRT0</accession>
    <name>A0A7U8TRT0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04058</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1765"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1765" mass="176105" checksum="D5824640BE54CA35" modified="2021-06-02" version="1" fragment="single">NVGSYNVGAGNVGSYNVGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIVSTGLFNAGGFNTGVVNAGSYNTGSFNAGEANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGVLWRGDYQGLLGFSSGANVLPVIPLSLDINGGVGAITIEPIHILPDIPININETLYLGPLVVPPINVPAISLGVGIPNISIGPIKINPITLWPAQNFNQTITLAWPVSSITIPQIQQVALSPSPIPTTLIGPIHINTGFSIPVTFSYSTPALTLFPVGLSIPTGGPLTLTLGVTAGTEAFTIPGFSIPEQPLPLAINVIGHINALSTPAITIDNIPLNLHAIGGVGPVDIVGGNVPASPGFGNSTTAPSSGFFNTGAGGVSGFGNVGAHTSGWFNQSTQAMQVLPGTVSGYFNSGTLMSGIGNVGTQLSGMLSGGALGGNNFGLGNIGFDNVGFGNAGSSNFGLANMGIGNIGLANTGNGNIGIGLSGDNLTGFGGFNSGSENVGLFNSGTGNVGFFNSGTGNLGVFNSGSHNTGFFLTGNNINVLAPFTPGTLFTISEIPIDLQVIGGIGPIHVQPIDIPAFDIQITGGFIGIREFTLPEITIPAIPIHVTGTVGLEGFHVNPAFVLFGQTAMAEITANPVVLPDPFITIDHYGPPLGPPGAKFPSGSFYLSISDLQINGPIIGSYGGPGTIPGPFGATFNLSTSSLALFPAGLTVPDQTPVTVNLTGGLDSITLFPGGLAFPENPVVSLTNFSVGTGGFTVFPQGFTVDRIPVDLHTTLSIGPFPFRWDYIPPTPANGPIPAVPGGFGLTSGLFPFHFTLNGGIGPISIPTTTVVDALNPLLTVTGNLEVGPFTVPDIPIPAINFGLDGNVNVSFNAPATTLLSGLGITGSIDISGIQITNIQTQPAQLFMSVGQTLFLFDFRDGIELNPIVIPGSSIPITMAGLSIPLPTVSESIPLNFSFGSPASTVKSMILHEILPIDVSINLEDAVFIPATVLPAIPLNVDVTIPVGPINIPIITEPGSGNSTTTTSDPFSGLAVPGLGVGLLGLFDGSIANNLISGFNSAVGIVGVNLGLANVGLFNAGSGNVGSYNVGAGNVGSYNVGGGNIGGNNVGLGNVGWGNFGLGNSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIVSTGLFNAGGFNTGVVNAGSYNTGSFNAGQANTGGFNPGSVNTGWLNTGDINTGVANSGDVNTGAFISGNYSNGVLWRGDYQGLLGFSYRPAVLPQTPFLDLTLTGGLGSVVIPAIDIPAIRPEFSANVAIDSFTVPSIPIPQIDLAATTVSVGLGPITVPHLDIPRVPVTLNYLFGSQPGGPLKIGPITGLFNTPIGLTPLALSQIVIGASSSQGTITAFLANLPFSTPVVTIDEIPLLASITGHSEPVDIFPGGLTIPAMNPLSINLSGGTGAVTIPAITIGEIPFDLVAHSTLGPVHILIDLPAVPGFGNTTGAPSSGFFNSGAGGVSGFGNVGAMVSGGWNQAPSALLGGGSGVFNAGTLHSGVLNFGSGMSGLFNTSVLGLGAPALVSGLGSVGQQLSGLLASGTALHQGLVLNFGLADVGWQCRVGNVGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRU1</accession>
    <name>A0A7U8TRU1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="85" mass="8933" checksum="B7241AF3DC13BE51" modified="2021-06-02" version="1">MTVRAVLRRTVGAQWPILAGVNFWRRGALLIGIGVGVAAVLRLVLSEERAGLLVVRSKGIDFVTTVTVAAAMVYIASTIDPLGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRU7</accession>
    <name>A0A7U8TRU7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_04012</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="6">
        <location>
            <begin position="161"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="290" mass="30340" checksum="9B350666FB333567" modified="2021-06-02" version="1">MAIDPNSIGAVTEPMLFEWTDRDTLLYAIGVGAGTGDLAFTTENSHGIDQQVLPTYAVICCPAFGAAAKVGTFNPAALLHGSQGIRLHAPLPAAGKLSVVTEVADIQDKGEGKNAIVVLRGRGCDPESGSLVAETLTTLVLRGQGGFGGARGERPAAPEFPDRHPDARIDMPTREDQALIYRLSGDRNPLHSDPWFATQLAGFPKPILHGLCTYGVAGRALVAELGGGVAANITSIAARVTKPVFPGETLSTGIWRTEPGRAMFRTEVAGSDGRRGPGGARRRCGEYAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TS13</accession>
    <name>A0A7U8TS13_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsM</name>
        <name evidence="8" type="ORF">TBLG_04113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418360.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TS13"/>
    <dbReference type="GeneID" id="45427449"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="124" mass="14351" checksum="93B44CB17A4503B1" modified="2021-06-02" version="1">MARLVGVDLPRDKRMEVALTYIFGIGRTRSNEILAATGIDRDLRTRDLTEEQLIHLRDYIEANLKVEGDLRREVQADIRRKIEIGCYQGLRHRRGMPVRGQRTKTNARTRKGPKRTIAGKKKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT04</accession>
    <name>A0A7U8TT04_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416799.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT04"/>
    <dbReference type="GeneID" id="45427182"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031529299" description="Endopeptidase La" evidence="2">
        <location>
            <begin position="24"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="112"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="4">
        <location>
            <begin position="233"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="340" mass="35473" checksum="0455561371799322" modified="2021-06-02" version="1">MNRRILTLMVALVPIVVFGVLLAVVTVPFVALGPGPTFDTLGEIDGKQVVQIVGTQTYPTSGHLNMTTVSQRDGLTLGEALALWLSGQEQLMPRDLVYPPGKSREEIENDNAADFKRSEAAAEYAALGYLKYPKAVTVASVMDPGPSVDKLQAGDAIDAVDGTPVGNLDQFTALLKNTKPGQEVTIDFRRKNEPPGIAQITLGKNKDRDQGVLGIEVVDAPWAPFAVDFHLANVGGPSAGLMFSLAVVDKLTSGHLVGSTFVAGTGTIAVDGKVGQIGGITHKMAAARAAGATVFLVPAKNCYEASSDSPPGLKLVKVETLSQAVDALHAMTSGSPTPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTL8</accession>
    <name>A0A7U8TTL8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_04130</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="8"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="338"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD15236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="497" mass="53272" checksum="06D661EE0B5658C7" modified="2021-06-02" version="1">MSQTARRLGPQDMFFLYSESSTTMMHVGALMPFTPPSGAPPDLLRQLVDESKASEVVEPWSLRLSHPELLYHPTQSWVVDDNFDLDYHVRRSALASPGDERELGIPVSRLHSHALDLRRPPWEVHFIEGLEGGRFAIYIKMHHSLIDGYTGQKMLARSLSTDPHDTTHPLFFNIPTPGRSPADTQDSVGGGLIAGAGNVLDGLGDVVRGLGGLVSGVGSVLGSVAGAGRSTFELTKALVNAQLRSDHEYLNLVGSVQAPHCILNTRISRNRRFATQQYPLDRLKAIGAQYDATINDVALAIIGGGLRRFLDELGELPNKSLIVVLPVNVRPKDDEGGGNAVATILATLGTDVADPVQRLAAVTASTRAAKAQLRSMDKDAILAYSAALMAPYGVQLASTLSGVKPPWPYTFNLCVSNVPGPEDVLYLRGSRMEASYPVSLVAHSQALNVTLQSYAGTLNFGFIGCRDTLPHLQRLAVYTGEALDQLAAADGAAGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTW1</accession>
    <name>A0A7U8TTW1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417120.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTW1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="394" mass="42459" checksum="FF4AE7C448ED5FD3" modified="2021-06-02" version="1">MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAARQITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDLVVAAEAGMTTGMPTPEGKPQIIPFQLVDNASGHVLAQAVLAALLHRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKGVGFATQPSDAFRTADGYIVISAYVPKHWQKLCYLIGRPDLVEDQRFAEQRSRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDTPLFAENDLTLEVGRGADTITVIRTPARYASFRAVVTDPPPTAGEHNAVFLARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y1Z5</accession>
    <name>A0A7U8Y1Z5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_02673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402904.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y1Z5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031515426" description="Phosphate transporter" evidence="8">
        <location>
            <begin position="18"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="388"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="417" mass="42735" checksum="D22C23184E508B5B" modified="2021-06-02" version="1">MNLQLFLLLIVVVTALAFDFTNGFHDTGNAMATSIASGALAPRVAVALSAVLNLIGAFLSTAVAATIAKGLIDANLVTLELVFAGLVGGIVWNLLTWLLGIPSSSSHALIGGIVGATIAAVGLRGVIWSGVVSKVIVPAVVAALLATLVGAVGTWLVYRTTRGVAEKRTERGFRRGQIGSASLVSLAHGTNDAQKTMGVIFLALMSYGAVSTTASVPPLWVIVSCAVAMAAGTYLGGWRIIRTLGKGLVEIKPPQGMAAESSSAAVILLSAHFGYALSTTQVATGSVLGSGVGKPGAEVRWGVAGRMVVAWLVTLPLAGLVGAFTYGLVHFIGGYPGAILGFALLWLTATAIWLRSRRAPIDHTNVNADWEGNLTAGLEAGAQPLADQRPPVPAPPAPTPPPNHRAPQFGVTTRNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y252</accession>
    <name>A0A7U8Y252_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403497.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y252"/>
    <dbReference type="GeneID" id="45424659"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023871">
        <property type="entry name" value="MftE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03964">
        <property type="entry name" value="mycofact_creat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="251" mass="26580" checksum="6C0882C57D15EAF0" modified="2021-06-02" version="1">MNSSYHRRVPVVGELGSATSSQLPSTSPSIVIPLGSTEQHGPHLPLDTDTRIATAVARTVTARLHAEDLPIAQEEWLMAPAIAYGASGEHQRFAGTISIGTEALTMLLVEYGRSAACWARRLVFVNGHGGNVGALTRAVGLLRAEGRDAGWCPCTCPGGDPHAGHTETSVLLHLSPADVRTERWRAGNRAPLPVLLPSMRRGGVAAVSETGVLGDPTTATAAEGRRIFAAMVDDCVRRVARWMPQPDGMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y285</accession>
    <name>A0A7U8Y285_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="64"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="304"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="426" mass="44963" checksum="359D38103153C05A" modified="2021-06-02" version="1">MQPLVVARRVDGAREAVDGSINTAGVFGRRNRYVAHWDDTGQADWVSGIGATLIRGDGRLDGPRRVVVTKSSGESVALTARHAVVICTGSRPALPDLPGITEARPWTNRQATDNSTVPDRLAIVGAGGVGVEMATAWQGLGASVTLLARGSGLLPRMEPFVGELIGRGLADAGVDVRVGVSVRALGRPNPTGPVVLELDDGTELRVDEVLFATGRAPRTDDIGLETIGLTPGSWLDVDDTCRVRAVDDGWLYAAGDVNHRALLTHQGKYQARIAGTAIGARAAGRPLDTTSWGMHATTADHHAVPQAFFTDPEAAAVGLTADQAAQAGHRIKAIDVEIGDVVMGAKLFADGYTGRARMVVDVDRGHLLGVTMVGPGAAELLHSATVAVAGQVPIDRLWHAVPCFPTISELWLRLLESYRDSFYLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2A7</accession>
    <name>A0A7U8Y2A7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-2-naphthoyl-CoA synthase</fullName>
            <shortName evidence="3">DHNA-CoA synthase</shortName>
            <ecNumber evidence="3">4.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menB</name>
        <name evidence="4" type="ORF">TBLG_02676</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26562"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57364"/>
            <dbReference type="ChEBI" id="CHEBI:58897"/>
            <dbReference type="EC" id="4.1.3.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 6/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00167"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008935">
        <property type="term" value="F:1,4-dihydroxy-2-naphthoyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01934">
        <property type="entry name" value="MenB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010198">
        <property type="entry name" value="DHNA-CoA_synthase_MenB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43113">
        <property type="entry name" value="PTHR43113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01929">
        <property type="entry name" value="menB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="103"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="157"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="314" mass="34670" checksum="AF297C017F6B061D" modified="2021-06-02" version="1">MVAPAGEQGRSSTALSDNPFDAKAWRLVDGFDDLTDITYHHHVDDATVRVAFNRPEVRNAFRPHTVDELYRVLDHARMSPDVGVVLLTGNGPSPKDGGWAFCSGGDQRIRGRSGYQYASGDTADTVDVARAGRLHILEVQRLIRFMPKVVICLVNGWAAGGGHSLHVVCDLTLASREYARFKQTDADVGSFDGGYGSAYLARQVGQKFAREIFFLGRTYTAEQMHQMGAVNAVAEHAELETVGLQWAAEINAKSPQAQRMLKFAFNLLDDGLVGQQLFAGEATRLAYMTDEAVEGRDAFLQKRPPDWSPFPRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2E3</accession>
    <name>A0A7U8Y2E3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403368.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2E3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="51" mass="5905" checksum="5480968ED5001858" modified="2021-06-02" version="1">MSVTQIDLDDEALADVMRIAAVHTKKEAVNLAMRDYVERFRRIEALARSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2I6</accession>
    <name>A0A7U8Y2I6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898733.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="232" mass="24082" checksum="031ED9350FF504ED" modified="2021-06-02" version="1">MISTTRIDFLWILSVAFASMIALATLLTLINQVVGTPYIPGGDSPAGTDCSELASWVSNAATARPVFGDRFNTGNEEAALAARGFQQGTAPNALVIGWNGHHTAVTLPDGTPVSSGEGGGVRVGGGGAYQPKFTHHMYLPMDVDAGEDQPPAPDEPVTAVDDVEPEMPAPCPTQRPPVTPRHNLCNKLRTMPGALSAALAAAAPVWPAPISGCRGFSTSLLAKRNHPVIVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2J1</accession>
    <name>A0A7U8Y2J1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="2">
        <location>
            <begin position="45"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="3">
        <location>
            <begin position="309"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="526" mass="57725" checksum="C9D75AFAC09615F3" modified="2021-06-02" version="1">MPGQDTKVRFFRVFCWCPVLRMVRIMLMHAVRAWRSADDFPCTEHMAYKIAQVAADPVDVDPEVADMVCNRIIDNAAVSAASMVRRPVTVARHQALAHPVRHGAKVFGVEGSYSADWAAWANGVAARELDFHDTFLAADYSHPADNIPPLVAVAQQLGVCGAELIRGLVTAYEIHIDLTRGICLHEHKIDHVAHLGPAVAAGIGTMLRLDQETIYHAIGQALHLTTSTRQSRKGAISSWKAFAPAHAGKVGIEAVDRAMRGEGSPAPIWEGEDGVIAWLLAGPEHTYRVPLPAPGEPKRAILDSYTKQHSAEYQSQAPIDLACRLRERIGDLDQIASIVLHTSHHTHVVIGTGSGDPQKFDPDASRETLDHSLPYIFAVALQDGCWHHERSYAPERARRSDTVALWHKISTVEDPEWTRRYHCADPAKKAFGARAEVTLHSGEVIVDELAVADAHPLGTRPFERKQYVEKFTELADGVVEPVEQQRFLAVVESLADLESGAVGGLNVLVDPRVLDKAPVIPPGIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2J3</accession>
    <name>A0A7U8Y2J3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405961.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2J3"/>
    <dbReference type="GeneID" id="45425117"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="250" mass="25788" checksum="123A1005A12BD6B6" modified="2021-06-02" version="1">MKTKDAVAVVTGGASGLGLATTKRLLDAGAQVVVVDLRGDDVVGGLGDRARFAQADVTDEAAVSNALELADSLGPVRVVVNCAGTGNAIRVLSRDGVFPLAAFRKIVDINLVGTFNVLRLGAERIAKTEPIGEERGVIINTASVAAFDGQIGQAAYSASKGGVVGMTLPIARDLASKLIRVVTIAPGLFDTPLLASLPAEAKASLGQQVPHPSRLGNPDEYGALVLHIIENPMLNGEVIRLDGAIRMAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2L6</accession>
    <name>A0A7U8Y2L6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02768</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="279" mass="32290" checksum="72DC41D1F824E0BB" modified="2021-06-02" version="1">MVDSMGWVLSSWHEVTGVDSGTWLAWVAWAALGLGVVALVVTKRQIQRNRRLAAEQTRPYVAMFMEPHVADWHVIELVVRNFGRTAAYDVRFSFPNPPTVAQYENAANGYADVVELRLPQELPMLAPGQEWRMVWDSALDRAEIGRGIESRFPGTVTYYDRPEQPRRWRFWRRGRRPLETKVVLDWDALPPVARIELMTTHDLAKREKQKLELLRSLLTYFHYASKETRPDVFRSEIDRINRAAAETQDRWRARQVEVPTEVSQRSEGQGPQPTRIPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2V5</accession>
    <name>A0A7U8Y2V5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="228" mass="23987" checksum="055420030606310E" modified="2021-06-02" version="1">MPHPTTLMKLTTRCGSAAIDGLNEALLAKAAEAKLLGTNRIRADTTVARANVSYPTDLGLLAKAMRRIAAIGKRIQAAGGAVRTRVGDRSRAAGRRAHAVAAKLRSRAELGRDEARAAVLRFTGELAELAQAAAQEAQQLLDNAKQAVLRAKAKAAALAARGERDAVAGRRCGGLVRAVNDLTELLNATRQIVAQTRQRVAGITSDGASRRVSLHDGDARPDHQGSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y328</accession>
    <name>A0A7U8Y328_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrate reductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03338</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406090.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y328"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10557">
        <property type="entry name" value="NarH_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="558" mass="62038" checksum="F8CD674042F03F0B" modified="2021-06-02" version="1">MKVMAQMAMVMNLDKCIGCHTCSVTCKQAWTNRSGTEYVWFNNVETRPGVGYPRTYEDQERWRGGWVRDKKGRLRLRDGGRIHKLLRIFANPKLPTIGDYYEPWTYDYENLTSAPAGDTFPTAAPRSLISGNPMKVSWGSNWDDNLAGSPEIVPNDPVLKKVNQVNQEVKLKLEETFMFYLPRICEHCLNPSCVASCPSGAMYKRTEDGIVLVDQDRCRGWRMCVSGCPYKKVYFNHKTGKAEKCTLCYPRIEVGLPTVCSETCVGRLRYLGLVLYDVDQVLQAASVESDTDLYEAQRRILLDPHDPRVIAGARAEGIADEWIEAAQRSPVYALINTYRVALPLHPEYRTMPMVWYIPPLSPVVDAVSRDGHDGEDLGNLFGALDALRIPIAYLAELFTAGDTEVVAGVLRRLAAMRCYMRDINLGRETQPHIPESVGMTEEQIYQMYRLLAVAKYEERYVIPTSYAGELPAAAMTDDMGCSLSVDGGPGMYESGPFGQGSPTPVPIAVESFHALQHAGSAATGGAGRSRVNLLNWDPNGAAAGLFPEPQPSKDVVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y334</accession>
    <name>A0A7U8Y334_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ada regulatory protein alkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03501</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y334"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035451">
        <property type="entry name" value="Ada-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004026">
        <property type="entry name" value="Ada_DNA_repair_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010316">
        <property type="entry name" value="AlkA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037046">
        <property type="entry name" value="AlkA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02805">
        <property type="entry name" value="Ada_Zn_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06029">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01009">
        <property type="entry name" value="AlkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57884">
        <property type="entry name" value="SSF57884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="9">
        <location>
            <begin position="87"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="496" mass="53729" checksum="E0E1FDE9D824CF7B" modified="2021-06-02" version="1">MHDDFERCYRAVQSKDARFDGWFVVAVLTTGVYCRPSCPVRPPFARNVRFLPTAAAAQGEGFRACKRCRPDASPGSPEWNVRSDVVARAMRLIADGTVDRDGVSGLAAQLGYTIRQLERLLQAVVGAGPLALARAQRMQTARVLIETTNLPFGDVAFAAGFSSIRQFNDTVRLACDGTPTALRARAAARFESATASAGTVSLRLPVRAPFAFEGVFGHLAATAVPGCEEVRDGAYRRTLRLPWGNGIVSLTPAPDHVRCLLVLDDFRDLMTATARCRRLLDLDADPEAIVEALGADPDLRAVVGKAPGQRIPRTVDEAEFAVRAVLAQQVSTKAASTHAGRLVAAYGRPVHDRHGALTHTFPSIEQLAEIDPGHLAVPKARQRTINALVASLADKSLVLDAGCDWQRARGQLLALPGVGPWTAEVIAMRGLGDPDAFPASDLGLRLAAKKLGLPAQRRALTVHSARWRPWRSYATQHLWTTLEHPVNQWPPQEKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y338</accession>
    <name>A0A7U8Y338_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease adapter protein ClpS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpS</name>
        <name evidence="3" type="ORF">TBLG_03516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds to the N-terminal domain of the chaperone ClpA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406906.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y338"/>
    <dbReference type="GeneID" id="45425309"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00302">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022935">
        <property type="entry name" value="ClpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33473">
        <property type="entry name" value="PTHR33473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ClpS" evidence="2">
        <location>
            <begin position="25"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="101" mass="11222" checksum="D78302CEC5FF5E5D" modified="2021-06-02" version="1">MAVVSAPAKPGTTWQRESAPVDVTDRAWVTIVWDDPVNLMSYVTYVFQKLFGYSEPHATKLMLQVHNEGKAVVSAGSRESMEVDVSKLHAAGLWATMQQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y364</accession>
    <name>A0A7U8Y364_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y364"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014577">
        <property type="entry name" value="UCP033093_metalloPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033093">
        <property type="entry name" value="UCP_ML1119"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="35"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="417" mass="44791" checksum="2C0F1774D3330742" modified="2021-06-02" version="1">MSPRPGPAGRGPAPCRCADLHSLCVDSHALRRDGMRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLKALAADVGAEFVVVAGDVFEHNQLAPQIVGQSLEAMRVIGLPVYLLPGNHDPLDASSVYTSTLFRAERPDNVVVLDRAGVHEVRPGVQIVAAPWRSKAPTTDPVAEVLAGLPTDAAIRLLVAHGGVDALDPDHDKPSLIRLAALDDALTRQAIHYVALGDKHSLTQVGSSGRVWYSGAPEVTNFDDVEPDPGHVLVVDIDESDPRHPVTVDARRIGRWRFVTLHHQVDTSRDIADLDLNLDLMTDKDRTVVRLALTGSLTVTDRAALDTCLDKYARLFAWLGLWERHTDLAVIPVDAEFTDLGIGGFAAAAVDELVATARGGDDESAVDAQAALALLLRLADRGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y368</accession>
    <name>A0A7U8Y368_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406629.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425264"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030952595" evidence="1">
        <location>
            <begin position="34"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="37"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="111" mass="11025" checksum="46585EA14834BE41" modified="2021-06-02" version="1">MFTRRFAASMVGTTLTAATLGLAALGFAGTASASSTDEAFLAQLQADGITPPSAARAIKDAHAVCDALDEGHSAKAVIKAVAKATGLSAKGAKTFAVDAASAYCPQYVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y3A6</accession>
    <name>A0A7U8Y3A6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="54"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="274" mass="29320" checksum="830F032F9DF9FEC9" modified="2021-06-02" version="1">MTIDTPAREDQTLAATHRAMWALGDYALMAEEVMAPLGPILVAAAGIGPGVRVLDVAAGSGNISLPAAKTGATVISTDLTPELLQRSQARAAQQGLTLQYQEANAQALPFADDEFDTVISAIGVMFAPDHQAAADELVRVCRPGGTIGVISWTCEGFFGRMLATIRPYRPSVSADLPPSALWGREAYVTGLLGDGVTDLKTARGLLEVKRFDTAQAVHDYFKNNYGPTIEAYAHIGDNAVLAAELDRQLVELAAQYLSDGVMEWEYLLLTAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4B5</accession>
    <name>A0A7U8Y4B5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Galactose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="13">2.7.7.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">TBLG_02754</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>alpha-D-galactose 1-phosphate + UDP-alpha-D-glucose = alpha-D-glucose 1-phosphate + UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:13989"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="2.7.7.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.12" evidence="13"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4B5"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019779">
        <property type="entry name" value="GalP_UDPtransf1_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005850">
        <property type="entry name" value="GalP_Utransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11943">
        <property type="entry name" value="PTHR11943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02744">
        <property type="entry name" value="GalP_UDP_tr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00117">
        <property type="entry name" value="GAL_P_UDP_TRANSF_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 13" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="6 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="14">
        <location>
            <begin position="76"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="GalP_UDP_tr_C" evidence="15">
        <location>
            <begin position="246"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="10 12">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFD12170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="394" mass="43454" checksum="551525558C75801A" modified="2021-06-02" version="1">MSATPPPGGLDASVFIANERGRQLDEALPVGFCVVTAPTRWTLADGRDLLFFSLPGHVPAPVSDRRPLPERDPAPSRLRFDRATGQWVIVAAQRQDRTYKPPAARCPLCPGPTGLSSEVPAPDYDVVVFENRFPSLAGAGIAPIGAPDGDGFVSAPGHGRCEVICFSADHTGSFAGLDPAHARLVVHAWRHRTAELTALPGVAQVFCFENRGEEIGVTLTHPHGQIYAYPYLTPRTAAMLRQARRHRKRHGDNLFASLLAREVADGSRIVVRGELFTAFVPFAARWPVEVHIYPNRLVRNLTELNDGELDEFARIYLDVLQRFDRMYSSPLPYMSALHQFSEVQRDGYFHVELMSIRRSATKLKYLAAAESAMDAFIADVIPESVAARLRELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4K4</accession>
    <name>A0A7U8Y4K4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405836.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4K4"/>
    <dbReference type="GeneID" id="45425079"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="106" mass="11395" checksum="837F8B4BDAAC1C7C" modified="2021-06-02" version="1">MYLPWGVVLAGGANGFGAGAYQTGTICEVSTQIAVRLPDEIVAFIDDEVRGQHARSRAAVVLRALERERRRRLAERDAEILATNTSATGDLDTLAGHCARTALDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4K6</accession>
    <name>A0A7U8Y4K6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="312" mass="24413" checksum="2AD36217B2F1CF1E" modified="2021-06-02" version="1">MGGEGGKGGEGAYGGAGGAGGSAASIGNAAIGGNGGAGGNAQAPGGVGGAGGEGGDAQVGTNSPSNAEAGNGGSGGNGFDSFASGGTGGAGGTGGAGGRGGLLIGDGGAGGAGGVGGTGGSGAPGGGGGAGGDGGAANTDSAGSSRKAFGGDGGVGGDGASALGTGGEGGIGGQGGNGGAGGLLIGNGGAGGVGGTAGAGGTGGSGGAGGAGGAGGGGTNSGPGAAFGGNGNTGGNGGNGGAPGALGGKGGSGGLIGRAGSDGGVGAGGAGGAGGAGGTGGEGGTGGDGKTTDGNPGMGGSPGSAGQPGQPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4P1</accession>
    <name>A0A7U8Y4P1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03128</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="175" mass="18122" checksum="BEE00E9C11218CD0" modified="2021-06-02" version="1">AQWTLIAANPVAGMTAAVAVLIIACPCALGLATPTAIMVGTGRGAELGILVKGGEVLEASKKMETVSSIATARTASTLNPVATDTVAARSGAFTTILRSASYAATPTAPVTTVGTAFARNPCYTIADAPFVCRCPEKHRSPALVTCCWHPASAPRWPTRRPRHRRAARVDRSAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4V2</accession>
    <name>A0A7U8Y4V2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="11">RNAP omega subunit</shortName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10 11">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rpoZ</name>
        <name evidence="12" type="ORF">TBLG_03577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407248.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4V2"/>
    <dbReference type="GeneID" id="45425368"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="110" mass="11842" checksum="ED2FBEB38F46FF0F" modified="2021-06-02" version="1">MSISQSDASLAAVPAVDQFDPSSGASGGYDTPLGITNPPIDELLDRVSSKYALVIYAAKRARQINDYYNQLGEGILEYVGPLVEPGLQEKPLSIALREIHADLLEHTEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4W0</accession>
    <name>A0A7U8Y4W0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acid-CoA ligase fadD36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406218.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4W0"/>
    <dbReference type="GeneID" id="45425164"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="46"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="390"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="473" mass="49520" checksum="39EEC2B0D02BAD3D" modified="2021-06-02" version="1">MLLASLNPAVVSAADIADAVRIDGDVLSRSDLVGAATSVAERVAGAHRVAVLATPTASTVLAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWLGPLPDDPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPKGVQLSRRAIAADLDALAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRFGNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAGALKPARLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPGWVGLPLAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLFDGYLNQPDATAAAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVLLGHPDVAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHKRPREVRIVDALPRNALGKVLKKQLLSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4Y2</accession>
    <name>A0A7U8Y4Y2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406375.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="226" mass="25230" checksum="CCFFA2BEEB08B54B" modified="2021-06-02" version="1">MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMHGRRYGRPGGWQQAQQPDASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLESPEEESAARASGRVSRFRDETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVPVMTRLKQPERQVLDTLVDAGVARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLRAQGPDLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y536</accession>
    <name>A0A7U8Y536_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Transaldolase</fullName>
            <ecNumber evidence="6 8">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tal</name>
        <name evidence="9" type="ORF">TBLG_03639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the transaldolase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="6 8"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y536"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00955">
        <property type="entry name" value="Transaldolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00493">
        <property type="entry name" value="Transaldolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004732">
        <property type="entry name" value="Transaldolase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036915">
        <property type="entry name" value="Trnald_Bac_Plnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00876">
        <property type="entry name" value="tal_mycobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="8">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="373" mass="40691" checksum="CDB659CE154CF1E6" modified="2021-06-02" version="1">MTAQNPNLAALSAAGVSVWLDDLSRDRLRSGNLQELIDTKSVVGVTTNPSIFQKALSEGHTYDAQIAELAARGADVDATIRTVTTDDVRSACDVLVPQWEDSDGVDGRVSIEVDPRLAHETEKTIQQAIELWKIVDRPNLFIKIPATKAGLPAISAVLAEGISVNVTLIFSVQRYREVMDAYLTGMEKARQAGHSLSKIHSVASFFVSRVDTEIDKRLDRIGSRQALELRGQAGVANARLAYAAYREVFEDSDRYRSLKVDGARVQRPLWASTGVKNPDYSDTLYVTELVAPHTVNTMPEKTIDAVADHGVIQGDTVTGTASDAQAVFDQLGAIGIDLTDVFAVLEEEGVRKFEASWNELLQETRAHLDTAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7J9</accession>
    <name>A0A7U8Y7J9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417165.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="125" mass="13152" checksum="C3FF49EDC96E4A83" modified="2021-06-02" version="1">MHEVGGPSRGDRLGRDDSEVHSAIRFAVVAAVVGVGFLIMGALLVSTCSGVDTAACGPPQRILLALGGPLILCAAGLWAFLRTYRVWRAEGTWWGWHGAGWFLLTLMVLTLCIGVPPIAGPVMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7R1</accession>
    <name>A0A7U8Y7R1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_04104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418333.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7R1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007795">
        <property type="entry name" value="T7SS_EccB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044857">
        <property type="entry name" value="T7SS_EccB_R1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042485">
        <property type="entry name" value="T7SS_EccB_R3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40765">
        <property type="entry name" value="PTHR40765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05108">
        <property type="entry name" value="T7SS_ESX1_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03919">
        <property type="entry name" value="T7SS_EccB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD15210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="470" mass="48199" checksum="61833F78B676F584" modified="2021-06-02" version="1">MPSPATTWLHVSGYRFLLRRIECALLFGDVCAATGALRARTTSLALGCVLAIVAAMGCAFVALLRPQSALGQAPIVMGRESGALYVRVDDVWHPVLNLASARLIAATNANPQPVSESELGHTKRGPLLGIPGAPQLLDQPLAGAESAWAICDSDNGGSTTVVVGPAEDSSAQVLTAEQMILVATESGSPTYLLYGGRRAVVDLADPAVVWALRLQGRVPHVVAQSLLNAVPEAPRITAPRIRGGGRASVGLPGFLVGGVVRITRASGDEYYVVLEDGVQRIGQVAADLLRFGDSQGSVNVPTVAPDVIRVAPIVNTLPVSAFPDRPPTPVDGSPGRAVTTLCVTWTPAQPGAARVAFLAGSGPPVPLGGVPVTLAQADGRGPALDAVYLPPGRSAYVAARSLSGGGTGTRYLVTDTGVRFAIHDDDVAHDLGLPTAAIPAPWPVLATLPSGPELSRANASVARDTVAPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7X4</accession>
    <name>A0A7U8Y7X4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03661</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415944.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7X4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="287" mass="31249" checksum="AE811BD52912BD92" modified="2021-06-02" version="1">MRHDSRVLDNGGPDAADPDLLIDFRNVSLRRNGRTLVGPLDWAVELDERWVIVGPNGAGKTSLLRIAAAAEHPSSGVAFVLGERLGRVDVSELRARVGLSSSALAERVPGDERVRDLVVSAGYAVLGRWRERYEAVDYHRAIDMLESLGAEHLANRTYGTLSEGERKRVLIARALMTDPELLLLDEPAAGLDLGGREELVARLADLAADPDAPALVLVTHHVEEIPPGFSHCLLLSEARVVAAGLLPDALTAENLSTAFGQEITLEVADGRYFARRRRSRAAHRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Z5</accession>
    <name>A0A7U8Y7Z5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416902.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7Z5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="72" mass="7790" checksum="B19F600467979341" modified="2021-06-02" version="1">MPKAAMAKPAAAEQATGYVVGGISPFGQRKRLRTVVDVSALSWDRVLRCRQTALGRHGGPAGPDHLDQRDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y803</accession>
    <name>A0A7U8Y803_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03751</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899932.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y803"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="299"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD14853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="463" mass="50721" checksum="48CC60A8670F1D6B" modified="2021-06-02" version="1">MNHLTTLDAGFLKAEDVDRHVSLAIGALAVIEGPAPDQEAFLSSLAQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWRIALPRPGNEDQLFELIADLMARRLDRGRPLWEVWVIEGLADSKWAILTKLHHCMADGIAATHLLAGLSDESMSDSFASNIHTTMQSQSASVRRGGFRVNPSEALTASTAVMAGIVRAAKGASEIAAGVLSPAASSLNGPISDLRRYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNVLIQRGERPRFDSLRTLVPVSTRSNSALSKTDNRVSLMLPNLPVDQENPLQRLRIVHSRLTRAKAGGQRQFGNTLMAIANRLPFPMTAWAVGLLMRLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIAMQLRTSVAMLSYADDLYFGILADYDVVADAGQLARGIEDAVARLVAISKRRKVTRRRGALSLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y886</accession>
    <name>A0A7U8Y886_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418950.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y886"/>
    <dbReference type="GeneID" id="45427475"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="54" mass="5695" checksum="3406A9C3DF1FBC96" modified="2021-06-02" version="1">MSTKSDHGEIGDVEPLADSTASQARRVVAAYANDADECRIFLSMLGIGPAKLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y8A6</accession>
    <name>A0A7U8Y8A6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-acetylhomoserine sulfhydrylase metC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_04062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900028.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y8A6"/>
    <dbReference type="GeneID" id="45427341"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="449" mass="47371" checksum="3240E5B4827B0C47" modified="2021-06-02" version="1">MSADSNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQGRFPGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAARRFSADPQSVAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9X3</accession>
    <name>A0A7U8Y9X3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty-acid-CoA ligase fadD13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416081.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y9X3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="9"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="413"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="503" mass="54459" checksum="B4CF011549E7B620" modified="2021-06-02" version="1">MKNIGWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYGAPSAPVIDAIRAQADPPGTVTDWIGADSLAERLRSAAADEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIGGAVPAILNFMRQVPEFAELDAPDFRYFITGGAPMPEALIKIYAAKNIEVVQGYALTESCGGGTLLLSEDALRKAGSAGRATMFTDVAVRGDDGVIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNGWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKWGEIAAAIVVADQNEVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPTGKILKTVLREQYSATVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9Z0</accession>
    <name>A0A7U8Y9Z0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TBLG_03707</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="13">
        <location>
            <begin position="4"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="14">
        <location>
            <begin position="309"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD14809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="472" mass="52611" checksum="B0BF4BCC28BBF153" modified="2021-06-02" version="1">MRRLNGVDALMLYLDGGSAYNHTLKISVLDPSTDPDGWSWPKARQMFEERAHLLPVFRLRYLPTPLGLHHPIWVEDPEFDLDAHVRRVVCPAPGGMAEFCALVEQIYAHPLDRDRPLWQTWVVEGLDGGRVALVTLLHHAYSDGVGVLDMLAVFYNDTPDEAPVVAPPWEPPPLPSTRQRLGWALRDLPSRLGKIAPTVRAVRDRVRIEREFAKDGDRRVPPTFDRSAPPGPFQRGLSRSRRFSCESFPLAEVREVSKTLGVTINDVFLACVAGAVRRYLERCGSPPTDAMVATMPLAVTPAAERAHPGNYSSVDYVWLRADIADPLERLHATHLAAEATKQHFAQTKDADVGAVVELLPERLISGLARANARTKGRFDTFKNVVVSNVPGPREPRYLGRWRVDQWFSTGQISHGATLNMTVWSYCDQFNLCVMADAVAVRNTWELVGGFRASHEELLAAARAQATPKEMAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA66</accession>
    <name>A0A7U8YA66_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417045.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA66"/>
    <dbReference type="GeneID" id="45427245"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="55" mass="6107" checksum="4BE92E74AAB55FE0" modified="2021-06-02" version="1">MAAYRCPVCDYVYDEANGDAREGFPAGTGWDQIPDDWCCPDCAVREKVDFEKIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF50</accession>
    <name>A0A7U8TF50_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898507.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="113" mass="12777" checksum="08F7C0E60E10914B" modified="2021-06-02" version="1">MGEHAIKRHMRQRKPTKHPLAQKRGARILVLTDDPRRSVLIVPGCHLDSMRREKNAYYFQDGNALVGMVVSGGTVEYDADDRTYVVQLTDGRHTTESSFEHSSPSRSPQSDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF52</accession>
    <name>A0A7U8TF52_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome P450 135B1 cyp135B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402992.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF52"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="472" mass="50688" checksum="B7E2898BEE80863F" modified="2021-06-02" version="1">MSGTSSMGLPPGPRLSGSVQAVLMLRHGLRFLTACQRRYGSVFTLHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEANSMLAGLLGDSSLLLIDDDVHRDRRRLMSPPFHRDAVARQAGPIAEIAAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGASDPVRLAALRKVMPRLLNVGPWATLALANPSLLNNRLWSRLRRRIEEADALLYAEIADRRADPDLAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWALERLTRHPVTLAKAVQAADASAAGDPAGDEYLDAVAKETLRIRPVVYDVGRVLTEAVEVAGYRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRMVGATLSPTTWLPFGGGNRRCLGATFAMVEMRVVLREILRRVELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATSQATAQGAGCPAARGGGPSRAVGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF59</accession>
    <name>A0A7U8TF59_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="113" mass="12297" checksum="225FCBA0F73D20A0" modified="2021-06-02" version="1">MAIPGDLPCGANLRDPNSNDPLLTLSSKGQNPKLYANELSTVHPRFPSTRANGQTSTVLAPRRYCRSSSRSRPGARTPLPSRDPAGEDKEWSAMWMSGHTPSSTSSWSCRRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFA1</accession>
    <name>A0A7U8TFA1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Galactokinase</fullName>
            <ecNumber evidence="10">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galK</name>
        <name evidence="14" type="ORF">TBLG_02755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>alpha-D-galactose + ATP = ADP + alpha-D-galactose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="10"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00246">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022963">
        <property type="entry name" value="Galactokinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF6">
        <property type="entry name" value="PTHR10457:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="5 10 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="13">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="11">
        <location>
            <begin position="95"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="12">
        <location>
            <begin position="262"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="16"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="103"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="363" mass="37625" checksum="C061C4CBEB46F406" modified="2021-06-02" version="1">MTVSYGAPGRVNLIGEHTDYNLGFALPIALPRRTVVTFTPEHTGAITARSDRADGSARIPLDTTPGQVTGWAAYAAGAIWALRGAGHPVPGGAMSITSDVEIGSGLSSSAALIGAVLGAVGAATGTRIDRLERARLAQRAENDYVGAPTGLLDHLAALFGAPKTALLIDFRDITVRPVAFDPDACDVVLLLMDSRARHRHAGGEYALRRASCERAAADLGVSSLRAVQDRGLAALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHESMREDFAITTERIDLIAESAVRAGALGARMTGGGFGGAVIALVPADRARDVADTVRRAAVTAGYDEPAVSRTYAAPGAAECR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFD3</accession>
    <name>A0A7U8TFD3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403125.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFD3"/>
    <dbReference type="GeneID" id="45424564"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="85" mass="9681" checksum="3410851F93D4EACE" modified="2021-06-02" version="1">MSATIPARDLRNHTAEVLRRVAAGEEIEVLKDNRPVARIVPLKRRRQWLPAAEVIGELVRLGPDTTNLGEELRETLTQTTDDVRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFH5</accession>
    <name>A0A7U8TFH5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MDMPI_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403741.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFH5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017520">
        <property type="entry name" value="CHP03086"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03086">
        <property type="entry name" value="TIGR03086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="182" mass="19148" checksum="D0F73C3C37642FD7" modified="2021-06-02" version="1">MDPLMAHQRAQDAFAALLANVRADQLGGPTPCSEWTINDLIEHVVGGNEQVGRWAASPIEPPARPDGLVAAHQAAAAVAHEIFAAPGGMSATFKLPLGEVPGQVFIGLRTTDVLTHAWDLAAATGQSTDLDPELAVERLAAARALVGPQFRGPGKPFADEKPCPRERPPADQLAAFLGRTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFH7</accession>
    <name>A0A7U8TFH7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">adk</name>
        <name evidence="9" type="ORF">TBLG_02877</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403726.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFH7"/>
    <dbReference type="GeneID" id="45424698"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="181" mass="20125" checksum="8BF4829220AEEC52" modified="2021-06-02" version="1">MRVLLLGPPGAGKGTQAVKLAEKLGIPQISTGELFRRNIEEGTKLGVEAKRYLDAGDLVPSDLTNELVDDRLNNPDAANGFILDGYPRSVEQAKALHEMLERRGTDIDAVLEFRVSEEVLLERLKGRGRADDTDDVILNRMKVYRDETAPLLEYYRDQLKTVDAVGTMDEVFARALRALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFN8</accession>
    <name>A0A7U8TFN8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylosuccinate lyase</fullName>
            <shortName evidence="11">ASL</shortName>
            <ecNumber evidence="4 11">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_02923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 11"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFN8"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="12">
        <location>
            <begin position="365"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="472" mass="51036" checksum="9BDEA7848EB0CF10" modified="2021-06-02" version="1">MSIPNVLATRYASAEMVAIWSPEAKVVSERRLWLAVLRAQAELGVAVADSVLADYERVVDDVDLASISARERVLRHDVKARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLEVIFAHGVAAVARLAERAVSYRDLIMAGRSHNVAAQATTLGKRFASAAQEMMIALRRLRELIDRYPLRGIKGPMGTGQDMLDLLGGDRAALADLERRVADFLGFATVFNSVGQVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELATEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYASMVAELAGAQWNEGDVFCSVVRRVALPDSFFAVDGQIETFLTVLDEFGAYPAVIGRELDRYLPFLATTKVLMAAVRAGMGRESAHRLISEHAVATALAMREHGAEPDLLDRLAADPRLPLGRDALEAALADKKAFAGAAGDQVDDVVAMVDALVSRYPDAAKYTPGAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFP2</accession>
    <name>A0A7U8TFP2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02921</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403945.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFP2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041583">
        <property type="entry name" value="TetR_C_31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17940">
        <property type="entry name" value="TetR_C_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="207" mass="22382" checksum="C8B7D116C25C35C2" modified="2021-06-02" version="1">MGVTAAVTPKGERRRYALVSAAAELLGEGGFEAVRHRAVARRAGLPLASTTYYFSSLDDLIARAVEHIGMIEVAQLRARVSALSRRRRGPETTAVVLVDLLVGEMSSPGLAEQLISRYERHIACTRLPDLRESMRRSLRQRAEAVAEAIERSGRSAQIELVCTLICAVDGSVVSALVEGRDPRAAALATVVDLIDVLAPVDQRPVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFT4</accession>
    <name>A0A7U8TFT4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13896">
        <property type="entry name" value="CuRO_3_CopA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034279">
        <property type="entry name" value="CuRO_3_CopA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="83"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="190"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="394"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="504" mass="53799" checksum="B56F75A50D333882" modified="2021-06-02" version="1">MPELATSGNAFDKRRFSRRGFLGAGIASGFALAACASKPTASGAAGMTAAIDAAEAARPHSGRTVTATLTPQPARIDLGGPIVSTLTYGNTIPGPLIRATVGDEIVVSVTNRLGDPTSVHWHGIALRNDMDGTEPATANIGPGGDFTYRFSVPDPGTYWAHPHVGLQGDHGLYLPVVVDDPTEPGHYDAEWIIILDDWTDGIGKSPQQLYGELTDPNKPTMQNTTGMPEGEGVDSNLLGGDGGDIAYPYYLINGRIPVAATSFKAKPGQRIRIRIINSAADTAFRIALAGHSMTVTHTDGYPVIPTEVDALLIGMAERYDVMVNAAGGVFSLVALAEGKNALARALLSTGAGSPPDPQFRPDELNWRVGTVEMFTAATTANLGRPEPTHDLPVTLGGTMAKYDWTINGEPYSTTNPLHVRLGQRPTLMFDNTTMMYHPIHLHGHTFQMIKADGSPGARKDTVIVLPKQKMRAVLVADNPGVWVMHCHNNYHQVAGMATRLDYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFU9</accession>
    <name>A0A7U8TFU9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03013</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="183"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="392"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="542" mass="59785" checksum="FC787A917B3FCB6C" modified="2021-06-02" version="1">MQSDKTVLLEVDHELAGAARAAIAPFAELERAPEHVHTYRITPLALWNARAAGHDAEQVVDALVSYSRYAVPQPLLVDIVDTMARYGRLQLVKNPAHGLTLVSLDRAVLEEVLRNKKIAPMLGARIDDDTVVVHPSERGRVKQLLLKIGWPAEDLAGYVDGEAHPISLHQEGWQLRDYQRLAADSFWAGGSGVVVLPCGAGKTLVGAAAMAKAGATTLILVTNIVAARQWKRELVARTSLTENEIGEFSGERKEIRPVTISTYQMITRHTKGEYRHLELFDSRDWGLIIYDEVHLLPAPVFRMTADLQSKRRLGLTATLIREDGREGDVFSLIGPKRYDAPWKDIEAQGWIAPAECVEVRVTMTDSERMMYATAEPEERYRICSTVHTKIAVVKSILAKHPDEQTLVIGAYLDQLDELGAELGAPVIQGSTRTSEREALFDAFRRGEVATLVVSKVANFSIDLPEAAVAVQVSGTFGSRQEEAQRLGRILRPKADGGGAIFYSVVARDSLDAEYAAHRQRFLAEQGYGYIIRDADDLLGPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFV9</accession>
    <name>A0A7U8TFV9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="88" mass="9202" checksum="0FB7543858260CCA" modified="2021-06-02" version="1">MSAPPAQAPVCGALAARPTAPGNASCTRPAKRDCRYGSRCETCLPFALAKDCRQASSRLQAATEPDETTTTSVISMRSPGSLQYQPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFX7</accession>
    <name>A0A7U8TFX7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-CoA carboxylase carboxyl transferase beta subunit accD3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03058</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404691.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFX7"/>
    <dbReference type="GeneID" id="45424867"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000438">
        <property type="entry name" value="Acetyl_CoA_COase_Trfase_b_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01070">
        <property type="entry name" value="ACCCTRFRASEB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="242"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="495" mass="51772" checksum="156C96E927FF950C" modified="2021-06-02" version="1">MSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVFGRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQMVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLTVAEPGALIGFLGPRVYELLYGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDVPTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQRAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCLAELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWLAPLPPEGASAIVFRDTAHAAELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERLATRLQRYRRIGLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG61</accession>
    <name>A0A7U8TG61_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405582.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG61"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="371" mass="40249" checksum="E8B5D6DFDF924B08" modified="2021-06-02" version="1">MQASDRTWQSNFIRRWYFTETVEYRPLVKYDASMSWDERTVSALEGAFRSEVRARRVNGPHRDVIVSLDGAEFLVRWLTTGWPRQVAEALHATSRPDILAAPTMSPGARKAAHDAGVGWVDESGAADIHYRNTSTGTTLVIETKGAPPAPLDARIGWRRATLAVCEALLANIAGPTVASVVEATGLSMGSSAQALKFLEKNGHLASATARGPKSARLIVDRDALLDAYAEAADKLRSPISISTGVLWRDPTAGVVKAGQLWDAAGIEWAATSALSASLLAPMQTEIAPMEIYVPGRSWSDLRRAAMAAGLQEIAGGRLILRFFPTPACARLTEQNLQGFRSMLWPRVYADLRTAGVRGEDAAEHLREAMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG81</accession>
    <name>A0A7U8TG81_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">greA</name>
        <name evidence="11" type="ORF">TBLG_03250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405742.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG81"/>
    <dbReference type="GeneID" id="45425053"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="82"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="164" mass="17855" checksum="22C65042E6DF3529" modified="2021-06-02" version="1">MTDTQVTWLTQESHDRLKAELDQLIANRPVIAAEINDRREEGDLRENGGYHAAREEQGQQEARIRQLQDLLSNAKVGEAPKQSGVALPGSVVKVYYNGDKSDSETFLIATRQEGVSDGKLEVYSPNSPLGGALIDAKVGETRSYTVPNGSTVSVTLVSAEPYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGA7</accession>
    <name>A0A7U8TGA7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="7">SHMT</shortName>
            <shortName evidence="7">Serine methylase</shortName>
            <ecNumber evidence="7">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glyA</name>
        <name evidence="10" type="ORF">TBLG_03267</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405797.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGA7"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="5"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="122"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7 8">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="426" mass="45001" checksum="9256AAEB7C1F9BA6" modified="2021-06-02" version="1">MSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFAPRAVLQAQGSVLTNKYAEGLPGRRYYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLHALMSPGERLLGLDLANGGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEFRPKVIIAGWSAYPRVLDFAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGGRSGLIVGKQQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFADRQRRTLSGARIIADRLMAPDVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEVGITVNRNAVPNDPRPPMVTSGLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVSALKDRATRLARAFPLYDGLEEWSLVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGF2</accession>
    <name>A0A7U8TGF2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GTP-binding protein TypA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="113" mass="12622" checksum="B014B0A2E25D4598" modified="2021-06-02" version="1" fragment="single">MRARHTGSLVSDRAGAITPFALLQLADRGQFFVEPGQQTYEGMVVGINPRPEDLDINVTREKKLTNMRSSTADVIETLAKPLQLDLERAMELCAPDECVEVTPEIVRIRKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGI8</accession>
    <name>A0A7U8TGI8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGI8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021465">
        <property type="entry name" value="DUF3117"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11314">
        <property type="entry name" value="DUF3117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="75" mass="7810" checksum="E9758D122BCDD945" modified="2021-06-02" version="1">MLGADQARAGGPARIWREHSMAAMKPRTGDGPLEATKEGRGIVMRVPLEGGGRLVVELTPDEAAALGDELKGVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGL3</accession>
    <name>A0A7U8TGL3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase DeaD</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cold-shock DEAD box protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">deaD</name>
        <name evidence="6" type="synonym">csdA</name>
        <name evidence="13" type="ORF">TBLG_03432</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DeaD/CsdA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070417">
        <property type="term" value="P:cellular response to cold"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12499">
        <property type="entry name" value="RRM_EcCsdA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00964">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034415">
        <property type="entry name" value="CsdA_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005580">
        <property type="entry name" value="DbpA/CsdA_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028618">
        <property type="entry name" value="DEAD_helicase_DeaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03880">
        <property type="entry name" value="DbpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="12">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="44"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="226"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="563" mass="61420" checksum="B95C4C79024AA1DB" modified="2021-06-02" version="1">MAFPEYSPAASAATFADLQIHPRVLRAIGDVGYESPTAIQAATIPALMAGSDVVGLAQTGTGKTAAFAIPMLSKIDITSKVPQALVLVPTRELALQVAEAFGRYGAYLSQLNVLPIYGGSSYAVQLAGLRRGAQVVVGTPGRVIDHLERATLDLSRVDFLVLDEADEMLTMGFADDVERILSETPEYKQVALFSATMPPAIRKLSAKYLHDPFEVTCKAKTAVAENISQSYIQVARKMDALTRVLEVEPFEAMIVFVRTKQATEEIAEKLRARGFSAAAISGDVPQAQRERTITALRDGDIDILVATDVAARGLDVERISHVLNYDIPHDTESYVHRIGRTGRAGRSGAALIFVSPRELHLLKAIEKATRQTLTEAQLPTVEDVNTQRVAKFADSITNALGGPGIELFRRLVKEYEREHDVPMADIAAALAVQCRGGEAFLMAPDPPLSRRNRDQRRDRPQRPKRRPDLTTYRVAVGKRHKIGPGAIVGAIANEGGLHRSDFGQIRIGPDFSLVELPAKLPRATLKKLAQTRISGVLIDLRPYRPPDAARRHNGGKPRRKHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGP8</accession>
    <name>A0A7U8TGP8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent helicase dinG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898827.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGP8"/>
    <dbReference type="GeneID" id="45425307"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="14"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="664" mass="70168" checksum="875A13606091CDB1" modified="2021-06-02" version="1">MSESVSMSVPELLAIAVAALGGTRRRGQQEMAAAVAHAFETGEHLVVQAGTGTGKSLAYLVPAIIRALCDDAPVVVSTATIALQRQLVDRDLPQLVDSLTNALPRRPKFALLKGRRNYLCLNKIHNSVTASDHDDERPQEELFDPVAVTALGRDVQRLTAWASTTVSGDRDDLKPGVGDRSWSQVSVSARECLGVARCPFGSECFSERARGAAGLADVVVTNHALLAIDAVAESAVLPEHRLLVVDEAHELADRVTSVAAAELTSATLGMAARRITRLVDPKVTQRLQAASATFSSAIHDARPGRIDCLDDEMATYLSALRDAASAARSAIDTGSDTTTASVRAEAGAVLTEISDTASRILASFAPAIPDRSDVVWLEHEDNHESARAVLRVAPLSVAELLATQVFARATTVLTSATLTIGGSFDAMATAWGLTADTPWRGLDVGSPFQHAKSGILYVAAHLPPPGRDGSGSAEQLTEIAELITAAGGRTLGLFSSMRAARAATEAMRERLSTPVLCQGDDSTSTLVEKFTADAATSLFGTLSLWQGVDVPGPSLSLVLIDRIPFPRPDDPLLSARQRAVAARGGNGFMTVAASHAALLLAQGSGRLLRRVTDRGVVAVLDSRMATARYGEFLRASLPPFWQTTNATQVRAALRRLARADAKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGS7</accession>
    <name>A0A7U8TGS7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycolipid sulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008146">
        <property type="term" value="F:sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000863">
        <property type="entry name" value="Sulfotransferase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00685">
        <property type="entry name" value="Sulfotransfer_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sulfotransfer_1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="326" mass="37022" checksum="CFBE7F67DF7F9BFB" modified="2021-06-02" version="1">MNSEHPMTDRVVYRSLMADNLRWDALQLRDGDIIISAPSKSGLTWTQRLVSLLVFDGPDLPGPLSTVSPWLDQTIRPIEEVVATLDAQQHRRFIKTHTPLDGLVLDDRVSYICVGRDPRDAAVSMLYQSANMNEDRMRILHEAVVPFHERIAPPFAELGHARSPTEEFRDWMEGPNQPPPGIGFTHLKGIGTLANILHQLGTVWVRRHLPNVALFHYADYQADLAGELLRLARVLGIAATRDRARDLAQYATLDAMRSRASEIAPNTTDGIWHSDERFFRRGGSGDWQQFFTEAEHLRYYHRINQLAPPDLLAWAHEGRRGYDPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGT0</accession>
    <name>A0A7U8TGT0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carbamoyl-phosphate synthase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="4">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="439" mass="47268" checksum="27B178C8019C23A7" modified="2021-06-02" version="1">ETVAELGLPVVVRPSFTMGGLGSGIAYSTDEVDRMAGAGLAASPSANVLIEESIYGWKEFELELMRDGHDNVVVVCSIENVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAILREVGVDTGGCNIQFAVNPRDGRLIVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEIVNDITGETPACFEPTLDYVVVKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFVEALGKVMRSLETTRAGFWTAPDPDGGIEEALTRLRTPAEGRFLRHRAGVAAGCDGGTGGRGQRCRPVFHRADQRAGQSAQRTRRGTRAERRAAAARQAQRTIGSPDRVAETGIGRRGRRAVTARAPGHPPGIQDGGHLRGGVRSPNPLPLQQLRARPRRRNRGGPADRKAQGADPRFGAQSDRPGYRVRLQLRTRGNHVEPGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGU5</accession>
    <name>A0A7U8TGU5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="356" mass="31319" checksum="650E4D2DAEFBBA1C" modified="2021-06-02" version="1">MHARGRPGGTRAAQARTGVSAQRAQRRARRHRAATAAACRAAAGPRGHGGQTGVGGKVGENNFGGAGGAGGTGGLIGNGGAGGTGGQGAISGAGGAGGNAWLIGDGGAGGNGGDIRGQGGGAGGAGGAGGQLIGNGGTGGAGGTVTSPNGLGGAGGAGGSAGLIGHGGTGGAGGHSAQGPDGNGGIGGAGGAGGNGGQLYGTGGTGGTGGKGGDGFGVFGKGGAGGTGGRGGAAGLIGDAGTGGTGGKGGTAGEDGTGGNGGTGGNGGAAVLIGNGGGGGAGGNGGAGNDGTPGNGGGGGVGVFFLFFCVSARPTRSARPARPRLTRPNRRGPRNPEKGWSTPGANIRWAQRHTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGX2</accession>
    <name>A0A7U8TGX2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD13044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="128" mass="14098" checksum="1101B3AB15CD6CD6" modified="2021-06-02" version="1" fragment="single">MTASRRSDHTDATRRALVDAGRYLFARRDYGDVSIEDIVTRARVTRGALDYHFDSKKDLFQTVLEVVEADLVADVEAAIAKVTDAWICWSSASTPSLTRRPNRMRCRSLRLTARQCSGGANGAGSTCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH13</accession>
    <name>A0A7U8TH13_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="45" mass="5518" checksum="6978FFC6A39D07DF" modified="2021-06-02" version="1">MVRKHAFHWRYDSTEELELLNQLWQLVSLRLNFFTPTKKALGFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH31</accession>
    <name>A0A7U8TH31_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 126 cyp126</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02924</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898584.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH31"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="414" mass="45954" checksum="2CCCBE0250818E3F" modified="2021-06-02" version="1">MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEHTPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPRHTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICILLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPADDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQLQTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRDPSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEPAEWTRSNRHTGIRHLVVELRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH58</accession>
    <name>A0A7U8TH58_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Demethylmenaquinone methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.163</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">menG</name>
        <name evidence="5" type="ORF">TBLG_02686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402936.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH58"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 4 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0830">Ubiquinone</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="234" mass="25299" checksum="220DE28AD89F2ABD" modified="2021-06-02" version="1">MSRAALDKDPRDVASMFDGVARKYDLTNTVLSLGQDRYWRRATRSALRIGPGQKVLDLAAGTAVSTVELTKSGAWCVAADFSVGMLAAGAARKVPKVAGDATRLPFGDDVFDAVTISFGLRNVANQQAALREMARVTRPGGRLLVCEFSTPTNALFATAYKEYLMRALPRVARAVSSNPEAYEYLAESIRAWPDQAVLAHQISRAGWSGVRWRNLTGGIVALHAGYKPGKQTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH80</accession>
    <name>A0A7U8TH80_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="6" type="ORF">TBLG_02795</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403365.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH80"/>
    <dbReference type="GeneID" id="45424616"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="127" mass="13960" checksum="FE33A563A46A0975" modified="2021-06-02" version="1">MAAATTTGTHRGLELRAAQRAVGSCEPQRAEFCRSARNADEFDQMSRMFGDVYPDVPVPKSVWRWIDSAQHRLARAGAVGALSVVDLLICDTAAARGLVVLHDDADYELAERHLPDIRVRRVVSADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THB3</accession>
    <name>A0A7U8THB3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900225.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="548" mass="57938" checksum="CB45FA24B081A560" modified="2021-06-02" version="1">MAPTPGRRTRNGSVNGHPGMANYPPDDANYRRSRRPPPMPSANRYLPPLGEQPEPERSRVPPRTTRAGERITVTRAAAMRSREMGSRMYLLVHRAATADGADKSGLTALTWPVMANFAVDSAMAVALANTLFFAAASGESKSRVALYLLITIAPFAVIAPLIGPALDRLQHGRRVALALSFGLRTALAVVLIMNYDGATGSFPSWVLYPCALAMMVFSKSFSVLRSAVTPRVMPPTIDLVRVNSRLTVFGLLGGTIAGGAIAAGVEFVCTHLFQLPGALFVVVAITIAGASLSMRIPRWVEVTSGEVPATLSYHRDRGRLRRRWPEEVKNLGGTLRQPLGRNIITSLWGNCTIKVMVGFLFLYPAFVAKAHEANGWVQLGMLGLIGAAAAVGNFAGNFTSARLQLGRPAVLVVRCTVLVTVLAIAAAVAGSLAATAIATLITAGSSAIAKASLDASLQHDLPEESRASGFGRSESTLQLAWVLGGAVGVLVYTELWVGFTAVSALLILGLAQTIVSFRGDSLIPGLGGNRPVMAEQETTRRGAAVAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THF2</accession>
    <name>A0A7U8THF2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03089</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031326">
        <property type="term" value="P:regulation of cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd14952">
        <property type="entry name" value="NHL_PKND_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035016">
        <property type="entry name" value="NHL_PKND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="15"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="414"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="498"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="540"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="8">
        <location>
            <begin position="624"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="303"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="664" mass="69514" checksum="0BCDC19C6050ACC0" modified="2021-06-02" version="1">MSDAVPQVGSQFGPYQLLRLLGRGGMGEVYEAEDTRKHRVVALKLISPQYSDNAVFRARMQREADTAGRLTEPHIVPIHDYGEINGQFFVEMRMIDGTSLRALLKQYGPLTPARAVAIVRQIAAALDAAHANGVTHRDVKPENILVTASDFAYLVDFGIARAASDPGLTQTGTAVGTYNYMAPERFTGDEVTYRADIYALACVLGECLTGAPPYRADSVERLIAAHLMDPAPQPSQLRPGRVPPALDQVIAKGMAKNPAERFMSAGDLAIAAHDALTTSEQHQATTILRRGDNATLLATPADTGLSQSESGIAGAGTGPPTPGAARWSPGDSATVAGPLAADSRGGNWPSQTGHSPAVPNALQASLGHAVPPAGNKRKVWAVVGAAAIVLVAIVAAAGYLVLRPSWSPTQASGQTVLPFTGIDFRLSPSGVAVDSAGNVYVTSEGMYGRVVKLATGSTGTTVLPFNGLYQPPGLAVDGAGTVYVTDFNNRVVTLAAGSNNQTVLPFDGLNYPEGLAVDTQGAVYVADRGNNRVVKLAAGSKTQTVLPFTGLNDPDGVAVDNSGNVYVTDTDNNRVVKLEAESNNQVVLPFTDITAPWGIAVDEAGTVYVTEHNTNQVVKLLAGSTTSTVLPFTGLNTPLAVAVDSDRTVYVADRGNDRVVKLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THI0</accession>
    <name>A0A7U8THI0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403738.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THI0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="165" mass="18079" checksum="CDDC565CC7FE0B0A" modified="2021-06-02" version="1">MASDNRDPIAAARANWERSGWGDVSLGMVAVTSVMRAHQILLARVETALRPYDLSFSRFELLRLLAFSRIGALPITKASDRLQVHVTSVTHAIRRLEADGLVRRVPHPTDGRTTLVQITELGRSTVEDATVTLNEQVFANVGMGAEESQALVSAVETLRRNAGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THL0</accession>
    <name>A0A7U8THL0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="8">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purC</name>
        <name evidence="10" type="ORF">TBLG_02926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="8"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403962.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THL0"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01058">
        <property type="entry name" value="SAICAR_SYNTHETASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="9">
        <location>
            <begin position="11"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="297" mass="32930" checksum="200D1EA37DF98637" modified="2021-06-02" version="1">MRPALSDYQHVASGKVREIYRVDDEHLLLVASDRISAYDYVLDSTIPDKGRVLTAMSAFFFGLVDAPNHLAGPPDDPRIPDEVLGRALVVRRLEMLPVECVARGYLTGSGLLDYQATGKVCGIALPPGLVEASRFATPLFTPATKAALGDHDENISFDRVVEMVGALRANQLRDRTLQTYVQAADHALTRGIIIADTKFEFGIDRHGNLLLADEIFTPDSSRYWPADDYRAGVVQTSFDKQFVRSWLTGSESGWDRGSDRPPPPLPEHIVEATRARYINAYERISELKFDDWIGPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THM6</accession>
    <name>A0A7U8THM6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein D 2 moaD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404559.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THM6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="92" mass="9440" checksum="0557800AF22DB372" modified="2021-06-02" version="1">MTQVSDESAGIQVTVRYFAAARAAAGAGSEKVTLRSGATVAELIDGLSVRDVRLATVLSRCSYLRDGIVVRDDAVALSAGDTIDVLPPFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THN7</accession>
    <name>A0A7U8THN7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404326.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424788"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="213" mass="23442" checksum="B39DAAC708C66C19" modified="2021-06-02" version="1">MQTGQNRGRWSGVPLESRHALRRDNLVAAGVQLLGGAGGPALTVRAVCRHAGLTERYFYESFADREHFVRAVYDDVCTRAMATLTSAQTPREAVEQFVELMVDDPVRGRVLLLAPAVEPALTRSGAEWMPNFIELLQRKLSRIVDPVLQKLVATSLIGALTGLFTAYLNGRLGATRKQFIDYCVNMLLSTAATYAPHRERGESEHSIPAGPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THY9</accession>
    <name>A0A7U8THY9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="249" mass="26745" checksum="4F574F5869BA794A" modified="2021-06-02" version="1" fragment="single">MAPDCGAVRIGNCSGFYGDRLSAMREMLTGGELDYLTGDYLAELTMLILGRDRMKNPDRGYAKTFLAQLEDCLGLAHDRGVRIVTNAGGLNPAGLANAVRALAARLGIPAQVAHVEGDDLQPRAAELGLGTPLTANAYLGAWGIVDCFERGADVVVTGRVTDASVVVGAAAAHFGWGRTDYHRLAGAVVAGHVIECGVQASGRQLRRLHRDRRPHSRRLLAGRDRCRRLVGDHQARRAPRLGGGRRLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI58</accession>
    <name>A0A7U8TI58_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI58"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="65"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="273" mass="29154" checksum="7F555606A74C55F7" modified="2021-06-02" version="1">MRRCIPHRCIGHGTVVSVRITVLGCSGSVVGPDSPASGYLLRAPHTPPLVIDFGGGVLGALQRHADPASVHVLLSHLHADHCLDLPGLFVWRRYHPSRPSGKALLYGPSDTWSRLGAASSPYGGEIDDCSDIFDVHHWADSEPVTLGALTIVPRLVAHPTESFGLRITDPSGASLAYSGDTGICDQLVELARGVDVFLCEASWTHSPKHPPDLHLSGTEAGMVAAQAGVRELLLTHIPPWTSREDVISEAKAEFDGPVHAVVCDETFEVRRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI96</accession>
    <name>A0A7U8TI96_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406064.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI96"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017658">
        <property type="entry name" value="CHP03252_HhH-GPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03252">
        <property type="entry name" value="TIGR03252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="1">
        <location>
            <begin position="25"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="195" mass="20872" checksum="C699C6B19D69FE95" modified="2021-06-02" version="1">MPNLQLVQEPAADALLNANPFALLVGMLLDQQVPMETAFAGPKKIADRMGSFDAGDIADYDPDKFVALCSERPAIHRFPGSMAKRIQALAQIIVDRYDGDAAALWTAGEPDGNELLRRLKGLPGFGEQKARIFLALLGKQYGVTPKGWQVAAGEFGQPGTYLSVADIVDAGSLGQVRSHKRQRKAAAKAEGKAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIA3</accession>
    <name>A0A7U8TIA3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein lprG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03599</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LppX/LprAFG lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407315.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIA3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16334">
        <property type="entry name" value="LppX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009830">
        <property type="entry name" value="LppX/LprAFG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07161">
        <property type="entry name" value="LppX_LprAFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031406066" evidence="4">
        <location>
            <begin position="31"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD13015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="236" mass="24548" checksum="2591DAE6D2E2DC22" modified="2021-06-02" version="1">MRTPRRHCRRIAVLAAVSIAATVVAGCSSGSKPSGGPLPDAKPLVEEATAQTKALKSAHMVLTVNGKIPGLSLKTLSGDLTTNPTAATGNVKLTLGGSDIDADFVVFDGILYATLTPNQWSDFGPAADIYDPAQVLNPDTGLANVLANFADAKAEGRDTINGQNTIRISGKVSAQAVNQIAPPFNATQPVPATVWIQETGDHQLAQAQLDRGSGNSVQMTLSKWGEKVQVTKPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR36</accession>
    <name>A0A7U8TR36_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03655</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002372">
        <property type="entry name" value="PQQ_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13360">
        <property type="entry name" value="PQQ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="360" mass="37323" checksum="4539FDBE33BBDB96" modified="2021-06-02" version="1">MAAGPALSARGYLALNGQTPAGCSLMEWQNDNNGRQRWCVRLVQGGGFAGPLFDGFDNLYVGQPGAIISFPPTQWTRWRQPVIGMPSTPRFLGHGRLLVSTHLGQLLVFDTRRGMVVGSPVDLVDGIDPTDATRGLADCAPARPGCPVAAAPAFSSVNGTVVVSVWQPGEPAAKLVGLKYHAEQLVREWTSDAVSAGVLASPVLSADGSTVYVNGRDHRLWALNAADGKAKWSAPLGFLAQTPPALTPHGLIVSGGGPDTALAAFRDAGDHAEGAWRRDDVTALSTASLAGTGVGYTVISGPNHDGTPGLSLLVFDPANGHTVNSYPLPGATGYPVGVSVGNDRRVVTATSDGQVYSFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR63</accession>
    <name>A0A7U8TR63_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR63"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="235"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="437" mass="45037" checksum="7514AF6FD6CAF242" modified="2021-06-02" version="1">MVSYVVALPEVMSAAATDVASIGSVVATASQGVAGATTTVLAAAEDEVSAAIAALFSAHGQDYQALSAQLAVFHERFVQALTGAAKGYAAAELANASLLQSEFASGIGNGFATIHQEIQRAPTALAAGFTQVPPFAAAQAGIFTGTPSGAAGFDIASLWPVKPLLSLSALETHFAIPNNPLLALIASDIPPLSWFLGNSPPPLLNSLLGQTVQYTTYDGMSVVQITPAHPTGEYVVAIHGGAFILPPSIFHWLNYSVTAYQTGATVQVPIYPLVQEGGTAGTVVPAMAGLISTQIAQHGVSNVSVVGDSAGGNLALAAAQYMVSQGNPVPSSMVLLSPWLDVGTWQISQAWAGNLAVNDPLVSPLYGSLNGLPPTYVYSGSLDPLAQQAVVLEHTAVVQGAPFSFVLAPWQIHDWILLTPWGLLSWPQINQQLGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR76</accession>
    <name>A0A7U8TR76_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002577">
        <property type="entry name" value="HTH_HxlR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01638">
        <property type="entry name" value="HxlR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51118">
        <property type="entry name" value="HTH_HXLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH hxlR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="104" mass="11711" checksum="C465E45B9C3B1C53" modified="2021-06-02" version="1">MSSRLRMLVEVGLFDRVPYSSDPERHEYRLTEAGRDLFAAIVVLMQWGDEYLPRPEGPPIKLRHHTCGEHADPRLICTHCGEEITARNVTPEPGPGFKAKLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR98</accession>
    <name>A0A7U8TR98_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03756</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416381.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR98"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022171">
        <property type="entry name" value="PPE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12484">
        <property type="entry name" value="PPE-SVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-SVP" evidence="3">
        <location>
            <begin position="300"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="380" mass="37980" checksum="345B1EF9EC9AE4AA" modified="2021-06-02" version="1">MDFALLPPEVNSARMYTGPGAGSLLAAAGGWDSLAAELATTAEAYGSVLSGLAALHWRGPAAESMAVTAAPYIGWLYTTAEKTQQTAIQARAAALAFEQAYAMTLPPPVVAANRIQLLALIATNFFGQNTAAIAATEAQYAEMWAQDAAAMYGYATASAAAALLTPFSPPRQTTNPAGLTAQAAAVSQATDPLSLLIETVTQALQALTIPSFIPEDFTFLDAIFAGYATVGVTQDVESFVAGTIGAESNLGLLNVGDENPAEVTPGDFGIGELVSATSPGGGVSASGAGGAASVGNTVLASVGRANSIGQLSVPPSWAAPSTRPVSALSPAGLTTLPGTDVAEHGMPGVPGVPVAAGRASGVLPRYGVRLTVMAHPPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRA0</accession>
    <name>A0A7U8TRA0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable NADH dehydrogenase I nuog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molydop_binding" evidence="1">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="196" mass="20499" checksum="051EB8F935D00D2C" modified="2021-06-02" version="1">MVFPVAPTTQKAGAFVNWEGRYRTFEPALRGSTLQAGQSDHRVLDALADDMGVHLGVPTVEAAREELAALGIWDGKHAAGPHIAATGPTQPEAGEAILTGWRMLLDEGRLQDGEPYLAGTARTPVVRLSPDTAAEIGAADGEAVTVSTSRGSITLPCSVTDMPDRVVWLPLNSAGSTVHRQLRVTIGSIVKIGAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRB0</accession>
    <name>A0A7U8TRB0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416593.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427153"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="160" mass="18023" checksum="04BF63428B2E9956" modified="2021-06-02" version="1">MKRLIALGIFLIVGIELLALILHDRRLVLAGSGLALALVLLNVRRMLGNRDELTAAPDSDDLGEGLRRWLSNTETTIRWSESTRADWDRHLRPMLARRFEIATGHRQAKDPVAFAATGRMLFGDELWEWVNPNNVTHTGDRQPGPGRAALEEILQKLEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRB2</accession>
    <name>A0A7U8TRB2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase fadE24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900638.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRB2"/>
    <dbReference type="GeneID" id="45427126"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="111"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="228"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="337"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD14862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="468" mass="49646" checksum="C7955D76B3CEE3B5" modified="2021-06-02" version="1">MTNTTSAANAAKPSGARTDRRGRTTGVGLAPHKRTGIDVALALLTPIVGQEFLDKYRLRDPLNRSLRYGVKTMFATAGAATRQFQRVQGLRGGPTRLKSSGRDYFDLTPDDDQKLIIETVDEFAEEVLRPAAHDADDAATYPSDLTAKAAELGITAINIPEDFDGIAEHRSSVTNVLVAEALAYGDMGLALPILAPGGVASALTHWGSADQQATYLKEFAGENVPQACVAITEPQPLFDPTRLKTTAVRTPSGYRLDGVKSLIPAAADAELFIVGAQLGGKPALFIVESAASGLTVKADPSMGIRGAALGQVELCGVSVPLNARLGEDEASDNDYSEALALARLGWAALAVGTSHAVLDYVVPYVKQRQAFGEPIAHRQAVAFMCANIAIELDGLRLITWRGASRAEQGLPFAREAALAKRLGSDKGMQIGLDGVQLLGGHGYTKEHPVERWYRDLRAIGVAEGVVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRB9</accession>
    <name>A0A7U8TRB9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900648.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427150"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="145" mass="14442" checksum="B905278D4EDD5456" modified="2021-06-02" version="1">MTSFAHPGTRGLSTVFGLMMVGSAAVGSHGLAVVVGLAAVIAVGVAAVFRLAATLAVVLSVVMIVVSGPTHVLAALSGFCAAVYLVCRYGAGVVAGSWPTTVAAVGFTFAGLAATSFPLQVPWLPLAAPLAVLATYVLATRPFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRC8</accession>
    <name>A0A7U8TRC8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UPF0182 protein TBLG_03818</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPF0182 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRC8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01600">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005372">
        <property type="entry name" value="UPF0182"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39344">
        <property type="entry name" value="PTHR39344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03699">
        <property type="entry name" value="UPF0182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="906"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="912"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="992" mass="107474" checksum="BF3C09B480567BBF" modified="2021-06-02" version="1">MGMRSAARMPKLTRRSRILIMIALGVIVLLLAGPRLIDAYVDWLWFGELGYRSVFTTMLATRIVVCLVAGVVVGGIVFGGLALAYRTRPVFVPDADNDPVARYRAVVLARLRLVGIGIPAAIGLLAGIVAQSYWARIQLFLHGGDFGVRDPQFGRDLGFYAFELPFYRLMLSYMLVSVFLAFVANLVAHYIFGGIRLSGRTGALSRSARVQLVSLVGVLVLLKAVAYWLDRYELLSHTRGGKPFTGAGYTDINAVLPAKLILMAIALICAAAVFSAIALRDLRIPAIGLVLLLLSSLIVGAGWPLIVEQISVKPNAAQKESEYISRSITATRQAYGLTSDVVTYRNYSGDSPATAQQVAADRATTSNIRLLDPTIVSPAFTQFQQGKNFYYFPDQLSIDRYLDRNGNLRDYVVAARELNPDRLIDNQRDWINRHTVYTHGNGFIASPANTVRGIANDPNQNGGYPEFLVNVVGANGTVVSDGPAPLDQPRIYFGPVISNTSADYAIVGRNGDDREYDYETNIDTKRYTYTGSGGVPLGGWLARSVFAAKFAERNFLFSNVIGSNSKILFNRDPAQRVEAVAPWLTTDSAVYPAIVNKRLVWIVDGYTTLDNYPYSELTSLSSATADSNEVAFNRLVPDKKVSYIRNSVKATVDAYDGTVTLYQQDEKDPVLKAWMQVFPGTVKPKSDIAPELAEHLRYPEDLFKVQRMLLAKYHVNDPVTFFSTSDFWDVPLDPNPTASSYQPPYYIVAKNIAKDDNSASYQLISAMNRFKRDYLAAYISASSDPATYGNLTVLTIPGQVNGPKLANNAITTDPAVSQDLGVIGRDNQNRIRWGNLLTLPVAQGGLLYVEPVYASPGASDAASSYPRLIRVAMMYNDKVGYGPTVRDALTGLFGPGAGATATGIAPTEAAVPPSPAANPPPPASGPQPPPVTAAPPVPVGAVTLSPAKVAALQEIQAAIGAARDAQKKGDFAAYGSALQRLDEAITKFNDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRE0</accession>
    <name>A0A7U8TRE0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416847.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRE0"/>
    <dbReference type="GeneID" id="45427196"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="101" mass="10988" checksum="2A86219FF2F03E5D" modified="2021-06-02" version="1">MAPVTDEQVELVRSLVAAIPLGRVSTYGDIAALAGLSSPRIVGWIMRTDSSDLPWHRVIRASGRPAQHLATRQLELLRAEGVLSVDGRVALSEIRYEFPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRE5</accession>
    <name>A0A7U8TRE5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416804.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRE5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018766">
        <property type="entry name" value="Zinicin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042271">
        <property type="entry name" value="Zinicin_2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39420">
        <property type="entry name" value="PTHR39420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10103">
        <property type="entry name" value="Zincin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03624">
        <property type="entry name" value="TIGR03624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="472" mass="49358" checksum="C5585A4BF67C5D23" modified="2021-06-02" version="1">MSTGEVMGDLPFGFSSGDDPPEDPSGRDKRGKDGADSGSGANPLGAFGIGGEFNMADLGQIFTRLGEMFGGVGTAMAAGKTSGPVNYDLARQVASSSIGFIAPIPAATNSAIADAVHLADTWLDGATSLPAGATKAVGWSPTDWVDNTLATWKRLCDPMAQQISTVWASSLPEEAKSMAGPLLSIMSQMGGIAFGSQLGQALGRLSREVLTSTDIGLPLGPKGVAAILPGAVESFAAGLEQPRSEILTFLATREAAHHRLFSHVPWLASQLLGAVEAYAMGMKIDMTGIEELARDINPTSLADPAAMEQLLSQGVFEPKATPAQTQALERLETLLALIEGWVQTVVTAALGERIPGEAALSETLRRRRASGGPAEQTFATLVGLELRPRKLREAGALWERLTRAVGMDARDAVWQHPDLLPATDDLDDPAAFIDRVIGGDTSGIDEAIAELERDQQARGADDSGHDGGPVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRF0</accession>
    <name>A0A7U8TRF0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methanol dehydrogenase transcriptional regulator moxR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416588.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRF0"/>
    <dbReference type="GeneID" id="45427152"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_3" evidence="1">
        <location>
            <begin position="42"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_lid_2" evidence="2">
        <location>
            <begin position="236"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="320" mass="35301" checksum="557115AF1D7D0E96" modified="2021-06-02" version="1">MIMPAATTTAHCEAVLDEIERVVVGKRSALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLDFTRVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLLADEINRTPPKTQAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTYPLPEAQLDRFAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVEQVTVHEDVLHYVVSLANATRHHPQVAVGASPRAELDLVQLSRARALLLGRDYVIPEDVKELATAAVAHRITLRPEMWVRKIAGADVVSELLRRLPVPRISGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRJ2</accession>
    <name>A0A7U8TRJ2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="137" mass="15179" checksum="15A119C9EACDA669" modified="2021-06-02" version="1">MGQIPPQPVRRVLPLMVVPGNGQKWRNRTETEEAMGDTYRDPVDHLRTTRPLAGESLIDVVHWPGYLLIVAGVVGGVGALAAFGTGHHAEGMTFGVVAIVVTVVGLAWLAFEHRRIRKIADRWYTEHPEVRRQRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRK5</accession>
    <name>A0A7U8TRK5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Succinate dehydrogenase flavoprotein subunit</fullName>
            <ecNumber evidence="5 16">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TBLG_03959</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>a quinone + succinate = a quinol + fumarate</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (bacterial route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 16"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRK5"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 16" id="KW-0274">FAD</keyword>
    <keyword evidence="9 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0813">Transport</keyword>
    <keyword evidence="8 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="17">
        <location>
            <begin position="8"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="18">
        <location>
            <begin position="457"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="15">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFD15061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="590" mass="64826" checksum="63AB833980D73AC1" modified="2021-06-02" version="1">MICQHRYDVVIVGAGGAGMRAAVEAGPRVRTAVLTKLYPTRSHTGAAQGGMCAALANVEDDNWEWHTFDTVKGGDYLADQDAVEIMCKEAIDAVLDLEKMGMPFNRTPEGRIDQRRFGGHTRDHGKAPVRRACYAADRTGHMILQTLYQNCVKHDVEFFNEFYALDLALTQTPSGPVATGVIAYELATGDIHVFHAKAVVIATGGSGRMYKTTSNAHTLTGDGIGIVFRKGLPLEDMEFHQFHPTGLAGLGILISEAVRGEGGRLLNGEGERFMERYAPTIVDLAPRDIVARSMVLEVLEGRGAGPLKDYVYIDVRHLGEEVLEAKLPDITEFARTYLGVDPVTELVPVYPTCHYLMGGIPTTVTGQVLRDNTSVVPGLYAAGECACVSVHGANRLGTNSLLDINVFGRRAGIAAASYAQGHDFVDMPPNPEAMVVGWVSDILSEHGNERVADIRGALQQSMDNNAAVFRTEETLKQALTDIHALKERYSRITVHDKGKRFNTDLLEAIELGFLLELAEVTVVGALNRKESRGGHAREDYPNRDDVNYMRHTMAYKEIGADKEGPELRSDVRLDFKPVVQTRYEPKERKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRM3</accession>
    <name>A0A7U8TRM3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417051.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="462" mass="51550" checksum="75EB8C218E253176" modified="2021-06-02" version="1">MVIGASIAGLCAARVLSDFYSTVTVFERDELPEAPANRATVPQDRHLHMLMARGAQEFDSLFPGLLHDMVAAGVPMLENRPDCIYLGAAGHVLGTGHTLRKEFTAYVPSRPHLEWQLRRRVLQLSNVQIVRRLVTEPQFERRQQRVVGVLLDSPGSGQDREREEFIAADLVVDAAGRGTRLPVWLTQWGYRRPAEDTVDIGISYASHQFRIPDGLIAEKVVVAGASHDQSLGLGMLCYEDGTWVLTTFGVADAKPPPTFDEMRALADKLLPARFTAALAQAQPIGCPAFHAFPASRWRRYDKLERFPRGIVPFGDAVASFNPTFGQGMTMTSLQAGHLRRALKARNSAMKGDLAAELNRATAKTTYPVWMMNAIGDISFHHATAEPLPRWWRPAGSLFDQFLGAAETDPVLAEWFLRRFSLLDSLYMVPSVPIIGRAIAHNLRLWLKEQRERRQPVTTRRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN0</accession>
    <name>A0A7U8TRN0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03951</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417254.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="308" mass="33649" checksum="4A642C261AAB9330" modified="2021-06-02" version="1">MTGPPPSLPERIRTDEADVLMLPDGRALAYLEWGDSTGYPAFYFHGTPSSRLEGAFADGAARRTGFRLIAIDRPGYGRSTFQAGRNFRDWPADVCALADAFELEEFGVVGHSGAGPHLFACGAVIPRTRLAFVGALGPWGPLATPDIMRSLNAADRCYARLARSGPRLFGALFAPLGWCAKYTPGLFSTLLAAAVPAADKHLLSDERFGRHLRAIQLEAFRQGSRGAAYESFLQFRPWGFDLAEVAVPTHIWLGDRDSFVPRAMGEYLQRAIPHVDLHWAHGKGHFNIEDWDAILAACALDIGKRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRR5</accession>
    <name>A0A7U8TRR5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="Far_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_4" evidence="1">
        <location>
            <begin position="5"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="259" mass="28782" checksum="97F5DC775CCD64CD" modified="2021-06-02" version="1" fragment="single">MRYVVTGGTGFIGRHVVSRLLDGRPEARLWALVRRQSLSRFERLAGQWGDRVRPLVGDLTELELSERTIAELGDIDHVLHCAAVHDTTWADATRAVIELAARLDATFHHVSSIAVAGDFAGHYTEADFDVGQRLPTPYHRMTFEAERLVRSTPGLRYRIYRPAVVVGDSRTGEMDTIDGPYYLFGVLAKLAVLPSFTPMLLPDIGRTNIVPVDYVADALVALMHADGRDGQTFHLTARQQSDCAHLRGNRRRATAPATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRU0</accession>
    <name>A0A7U8TRU0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663495">
        <property type="protein sequence ID" value="EFD15160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="5"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="141" mass="13814" checksum="34A9D20821BD1E5F" modified="2021-06-02" version="1">MSFVVMPPEINSLLIYTGAGPGPLLAAAAAWDELAAELGSAAAAFGSVTSGLVGGIWQGPSSVAMAAAAAPYAGWLSAAAASAESAAGQARAVVGVFEAALAATVDPFVIAANRSRLVSLALSNLFGQNTPAIAAAEFDYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRZ3</accession>
    <name>A0A7U8TRZ3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MCE-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418958.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRZ3"/>
    <dbReference type="GeneID" id="45427478"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="160" mass="18007" checksum="87D0286AFF544DB7" modified="2021-06-02" version="1">MRRLISVAYALMVATIVGLSAAGGWFYWDRVQTGGEASARALLPKLAMQEIPQVFGYDYQTVERSLTAVYPLLTPDYRQEFQKSANAQIIPEAKKREVVVQANVVGVGVMDAKRDCASVMVYLNRTVTDKTRQPLYDGSRLRVDFQRIDGKWLIAYITPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TS02</accession>
    <name>A0A7U8TS02_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein mce4D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04146</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418966.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TS02"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="122"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="451" mass="47233" checksum="EC489BE8FE9B0FA2" modified="2021-06-02" version="1">MMGRVAMLTGSRGLRYATVIALVAALVGGVYVLSSTGNKRTIVGYFTSAVGLYPGDQVRVLGVPVGEIDMIEPRSSDVKITMSVSKDVKVPVDVQAVIMSPNLVAARFIQLTPVYTGGAVLPDNGRIDLDRTAVPVEWDEVKEGLTRLAADLSPAAGELQGPLGAAINQAADTLDGNGDSLHNALRELAQVAGRLGDSRGDIFGTVKNLQVLVDALSESDEQIVQFAGHVASVSQVLADSSANLDQTLGTLNQALSDIRGFLRENNSTLIETVNQLNDFAQTLSDQSENIEQVLHVAGPGITNFYNIYDPAQGTLNGLLSIPNFANPVQFICGGSFDTAAGPSAPDYYRRAEICRERLGPVLRRLTVNYPPIMFHPLNTITAYKGQIIYDTPATEAKSETPVPELTWVPAGGGAPVGNPADLQSLLVPPAPGPAPAPPAPGAGPGEHGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT47</accession>
    <name>A0A7U8TT47_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416074.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT47"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="276" mass="29217" checksum="4721366EEBE3E270" modified="2021-06-02" version="1">MSSFEGKVAVITGAGSGIGRALALNLSEKRAKLALSDVDTDGLAKTVRLAQALGAQVKSDRLDVAEREAVLAHADAVVAHFGTVHQVYNNAGIAYNGNVDKSEFKDIERIIDVDFWGVVNGTKAFLPHVIASGDGHIVNISSLFGLIAVPGQSAYNAAKFAVRGFTEALRQEMLVARHPVKVTCVHPGGIKTAVARNATVADGEDQQTFAEFFDRRLALHSPEMAAKTIVNGVAKGQARVVVGLEAKAVDVLARIMGSSYQRLVAAGVAKFFPWAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTD1</accession>
    <name>A0A7U8TTD1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="63"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="225" mass="25022" checksum="088162CACEC262EA" modified="2021-06-02" version="1">MVRNAQRAVRRASGRRKAWLRQAINHLEKLIGRTERVVDQARSRLAGVMPDSSSRLVSLHDADARPIRKGRLGKPVEFGYKAQVVDNADGVILDHSVELGNPADAPQLAPAIERISRRTGRPPRAVTADRGCGDASVEDDLHQLGVRNVAIPRKSKPSATRRAFEHRRAFRDKIKWRTGSEGRINHLKRSYGWNRTELTGITGARTWCGHGVFAHNLVKISTLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTY6</accession>
    <name>A0A7U8TTY6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="7">1.1.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + sn-glycerol 3-phosphate = a quinol + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18977"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.1.5.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.5.3" evidence="7"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417217.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTY6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00977">
        <property type="entry name" value="FAD_G3PDH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="8">
        <location>
            <begin position="37"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="9">
        <location>
            <begin position="413"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD15043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="585" mass="62778" checksum="760C15F7E75BB69F" modified="2021-06-02" version="1">MSNPIQAPDGGQGWPAAALGPAQRAVAWKRLGTEQFDVVVIGGGVVGSGCALDAATRGLKVALVEARDLASGTSSRSSKMFHGGLRYLEQLEFGLVREALYERELSLTTLAPHLVKPLPFLFPLTKRWWERPYIAAGIFLYDRLGGAKSVPAQRHFTRAGALRLSPGLKRSSLIGGIRYYDTVVDDARHTMTVARTAAHYGAVVRCSTQVVALLREGDRVIGVGVRDSENGAVAEVRGHVVVNATGVWTDEIQALSKQRGRFQVRASKGVHVVVPRDRIVSDVAMILRTEKSVMFVIPWGSHWIIGTTDTDWNLDLAHPAATKADIDYILGTVNAVLATPLTHADIDGVYAGLRPLLAGESDDTSKLSREHAVAVPAAGLVAIAGGKYTTYRVMAADAIDAAVQFIPARVAPSITEKVSLLGADGYFALVNQAEHVGALQGLHPYRVRHLLDRYGSLISDVLAMAASDPSLLSPITEAPGYLKVEAAYAAAAEGALHLEDILARRMRISIEYPHRGVDCAREVAEVVAPVLGWTAADIDREVANYMARVEAEVLSQAQPDDVSADMLRASAPEARAEILEPVPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TU65</accession>
    <name>A0A7U8TU65_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04162</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663495">
        <property type="protein sequence ID" value="EFD15163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="233" mass="22968" checksum="B4EBB10E5BAE12A4" modified="2021-06-02" version="1">TSGSSSGFKVRPSFSFFAVGPDGMPGGEVSILQPFTVAPINLNPTTLHFPGFTIPTGPIHIGLPLSLTIPGFTIPGGTLIPQLPLGLGLSGGTPPFDLPTVVIDRIPVELHASTTIGPVSLPIFGFGGAPGFGNDTTAPSSGFFNTGGGGGSGFSNSGSGMSGVLNAISDPLLGSASGFANFGTQLSGILNRGAGISGVYNTGTLGLVTSAFVSGFMNVGQQLSGLLFAGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y260</accession>
    <name>A0A7U8Y260_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal peptide peptidase SppA, 67K type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02868</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y260"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004634">
        <property type="entry name" value="Pept_S49_pIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001217">
        <property type="entry name" value="Protease_4_SppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00705">
        <property type="entry name" value="SppA_67K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="129"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S49" evidence="5">
        <location>
            <begin position="403"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="623" mass="65936" checksum="4CCF55715DA4DDCC" modified="2021-06-02" version="1">MPIFGGFCVCSRALGGRWVRWVNMVAFLPSIPVVEDLRALVGRVDTARHHGVPNGCVLEFNLRSVPPETTGFDPLTVLTGGGRPMALRDAVAAIHRAAEDPRVAGLIARVQLPPSPAGAVQELREAIAAFSAVKPSLAWAETYPGTLSYYLASAFGEVWMQPSGSVGLVGFATNATFLRDALHKAGIEAQFVARGEYKSAANLFTEDGFTDAHREAVTRMLDSLQDQVWQAVAKSRNIGVDALDELADRAPLLRDDAVTCGLIDRIGFRDQAYARMAELVGVEKGSPESSGSQTSPDEKPPRMYLARYASSARPRLTPPVPSIPGRRSKPTIAVVTLEGPIVNGRGGPQFLPLGPSSAGGDTIAAALREVAADDSVSAIVLRVDSPGGSVTASETIWREVARARDRGKPVVASMGAVAASGGYYVSMGADAIVANPGTITGSIGVITGKLVVRDLKDRLGVGSDAVRTNANADAWSIDAPFTPDQQAHREAEADLFYSDFVERVAEGRKMTTDAVDVVARGRVWTGADALDRGLVDELGGLRTAVRRAKVLAGLDEDTEVRIVSYPGSSLWDMVRPRPSSRPAAASLPDAMGALLARSIVGIVEQVEQTLSGASVLWLGESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y292</accession>
    <name>A0A7U8Y292_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404335.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y292"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="130" mass="14296" checksum="DC6C2FD5B599D1A2" modified="2021-06-02" version="1">MYADSGPDPLPDDQVCLVVEVFRMLADATRVQVLWSLADREMSVNELAEQVGKPAPSVSQHLAKLRMARLVRTRRDGTTIFYRLENEHVRQLVIDAVFNAEHAGPGIPRHHRAAGGLQSVAKASATKDVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2A6</accession>
    <name>A0A7U8Y2A6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin converting factor, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="130" mass="13481" checksum="13420A9D333A26A6" modified="2021-06-02" version="1" fragment="single">MTQVLRAALTDQPIFLAEHEELVSHRSAGAIVGFVGMIRDRDGGRGVLRLEYSAHPSAAQVLADLVAEVAEESSGVRAVAASHRIGVLQVGEAALVAAVAADHRRAAFGTCAHLGGDHSRRGFPCGSTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2B1</accession>
    <name>A0A7U8Y2B1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">htpX</name>
        <name evidence="14" type="ORF">TBLG_02691</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402959.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="69"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="286" mass="30682" checksum="9D1ED210A449465D" modified="2021-06-02" version="1">MTWHPHANRLKTFLLLVGMSALIVAVGALFGRTALMLAALFAVGMNVYVYFNSDKLALRAMHAQPVSELQAPAMYRIVRELATSAHQPMPRLYISDTAAPNAFATGRNPRNAAVCCTTGILRILNERELRAVLGHELSHVYNRDILISCVAGALAAVITALANMAMWAGMFGGNRDNANPFALLLVALLGPIAATVIRMAVSRSREYQADESGAVLTGDPLALASALRKISGGVQAAPLPPEPQLASQAHLMIANPFRAGERIGSLFSTHPPIEDRIRRLEAMARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2F3</accession>
    <name>A0A7U8Y2F3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030818187" evidence="1">
        <location>
            <begin position="36"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="189" mass="17640" checksum="02176F362B44FC6B" modified="2021-06-02" version="1">MRLTRWSLPGILPTARGTASTVASLLLPGAQSAAAALPAVGLPALPGVTPASLLAMAAAAGLPGVGFPSLPGVSPTDLMAMAAAAGLPTSLPGLAGMSPAELTALVAGGLPMLAAAGLPAGLAGVDPATLAAALPALAAGLPALPAGLPPLPAVPALPAPPPLPGPPPLPALPSRLCTPGFGPIGVCIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2K3</accession>
    <name>A0A7U8Y2K3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406163.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425143"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="146" mass="15218" checksum="433A910C547E0E79" modified="2021-06-02" version="1">MGHRVDTLSDRQRANLTTGATDRAIRLVVLALLTVDGVVSALAGALLMPWYIGSAPFPISALISGLVNAALVWAAARWTTSSRVAALPLWAWLLTVAAMSFGGPGDDVILGGQGLLVYGALVFVVAGAVPPAWVLWRRRVQADGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2L3</accession>
    <name>A0A7U8Y2L3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl-diaminopimelate desuccinylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406235.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2L3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009014">
        <property type="term" value="F:succinyl-diaminopimelate desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010174">
        <property type="entry name" value="Succinyl-DAP_deSuclase_DapE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01900">
        <property type="entry name" value="dapE-gram_pos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="166"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="354" mass="37273" checksum="F8DA6ABA0E1CA6DB" modified="2021-06-02" version="1">MLDLRGDPIELTAALIDIPSESRKEARIADEVEAALRAQASGFEIIRNGNAVLARTKLNRSSRVLLAGHLDTVPVAGNLPSRRENDQLHGCGAADMKSGDAVFLHLAATLAEPTHDLTLVFYDCEEIDSAANGLGRIQRELPDWLSADVAILGEPTAGCIEAGCQGTLRVVLSVTGTRAHSARSWLGDNAIHKLGAVLDRLAVYRARSVDIDGCTYREGLSAVRVAGGVAGNVIPDAASVTINYRFAPDRSVAAALQHVHDVFDGLDVQIEQTDAAAGALPGLSEPAAKALVEAAGGQVRAKYGWTDVSRFAALGIPAVNYGPGDPNLAHCRDERVPVGNITAAVDLLRRYLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2N4</accession>
    <name>A0A7U8Y2N4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="76" mass="8443" checksum="9BCAD6B1F5724456" modified="2021-06-02" version="1">MSPAHSLVAINFKAEIVALQGWDRTRPCGRWSYARPDANLAQGNLNSMPQITASAKSPLARVQRRAAGCYRHLTRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2N7</accession>
    <name>A0A7U8Y2N7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sua5/YciO/YrdC/YwlC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2N7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="217" mass="22602" checksum="F3FB7ECBE80DE49E" modified="2021-06-02" version="1">MTETFDCADPEQRSRGIVSAVGAIKAGQLVVMPTDTVYGIGADAFDSSAVAALLSAKGRGRDMPVGVLVGSWHTIEGLVYSMPDGARELIRAFWPGALSLVVVQAPSLQWDLGDAHGTVMLRMPLHPVAIELLREVGPMAVSSANISGHPPPVDAEQARSQLGDHVAVYLDAGPSEQQAGSTIVDLTGATPRVLRQGPVSTERIAEVLGVDAASLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2W5</accession>
    <name>A0A7U8Y2W5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase lipU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900268.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2W5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="66"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="297" mass="31681" checksum="400FF66FEC76AEE5" modified="2021-06-02" version="1">MAVRPVLAVGSYLPHAPWPWGVIDQAARVLLPASTTVRAAVSLPNASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELLSKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGDSAGGYLALALAQRLQEVGEEPAALVAISPLLQLAKEHKQAHPNIKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTLIHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEAIRSLRQIGEYIREATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y324</accession>
    <name>A0A7U8Y324_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rv1128c/1148c/1588c/1702c/1945/3466 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="380"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="482" mass="52954" checksum="44F6F27E8BD30E63" modified="2021-06-02" version="1">MSETFCLTDHSEPMTARFLSVVLRRIRGMRSDTREEISAALDAYHASLSRVLDLKCDALTTPELLACLQRLEVERRRQGAAEHALINQLAGQACEEELGGTLRTALANRLHITPGEASRRIAEAEDLGERRALTGEPLPAQLTATAAAQREGKIGREHIKEIQAFFKELSAAVDLGIREAAEAQLAELATSRRPDHLHGLATQLMDWLHPDGNFSDQERARKRGITMGKQEFDGMSRISGLLTPELRATIEAVLAKLAAPGACNPDDQTPLVDDTPDADAVRRDTRSQAQRNHDAFLAALRGLLASGELGQHKGLPVTIVVSTTLKELEAATGKGVTGGGSRVPMSDLIRMASHANHYLALFDGAKPLALYHTKRLASPAQRIMLYAKDRGCSRPGCDAPAYHSEVHHVTPWTTTHRTDINDLTLACGPDNRLVEKGWKTRKNAHGDTEWLPPPHLDHGQPRINRYHHPAKILCEQDDDEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y355</accession>
    <name>A0A7U8Y355_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Guanylate kinase</fullName>
            <ecNumber evidence="2 9">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gmk</name>
        <name evidence="11" type="ORF">TBLG_03576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2 9"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900331.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y355"/>
    <dbReference type="GeneID" id="45425367"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="10">
        <location>
            <begin position="21"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="28"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="208" mass="22095" checksum="3D2948315974549F" modified="2021-06-02" version="1">MSVGEGPDTKPTARGQPAAVGRVVVLSGPSAVGKSTVVRCLRERIPNLHFSVSATTRAPRPGEVDGVDYHFIDPTRFQQLIDQGELLEWAEIHGGLHRSGTLAQPVRAAAATGVPVLIEVDLAGARAIKKTMPEAVTVFLAPPSWQDLQARLIGRGTETADVIQRRLDTARIELAAQGDFDKVVVNRRLESACAELVSLLVGTAPGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y3B9</accession>
    <name>A0A7U8Y3B9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ORF">TBLG_03638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407443.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y3B9"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="32"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="217"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD13054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="514" mass="57343" checksum="22A9CCEDC9AB062F" modified="2021-06-02" version="1">MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQITMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEHWAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y440</accession>
    <name>A0A7U8Y440_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methoxy mycolic acid synthase 1 mmaA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403310.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y440"/>
    <dbReference type="GeneID" id="45424605"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="286" mass="33149" checksum="229EB252DCA8C552" modified="2021-06-02" version="1">MAKLRPYYEESQSAYDISDDFFALFLDPTWVYTCAYFERDDMTLEEAQLAKVDLALDKLNLEPGMTLLDVGCGWGGALVRAVEKYDVNVIGLTLSRNHYERSKDRLAAIGTQRRAEARLQGWEEFEENVDRIVSFEAFDAFKKERYLTFFERSYDILPDDGRMLLHSLFTYDRRWLHEQGIALTMSDLRFLKFLRESIFPGGELPSEPDIVDNAQAAGFTIEHVQLLQQHYARTLDAWAANLQAARERAIAVQSEEVYNNFMHYLTGCAERFRRGLINVAQFTMTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4A8</accession>
    <name>A0A7U8Y4A8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline iminopeptidase pip</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02992</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404376.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4A8"/>
    <dbReference type="GeneID" id="45424806"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="24"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR005539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="286" mass="31925" checksum="95E42CF7ED2A52E7" modified="2021-06-02" version="1">MEGTIAVPGGRVWFQRIGGGPGRPLLVVHGGPGLPHNYLAPLRRLSDEREVIFWDQLGCGNSACPSDVDLWTMNRSVAEMATVAEALALTRFHIFSHSWGGMLAQQYVLDKAPDAVSLTIANSTASIPEFSASLVSLKSCLDVATRSAIDRHEAAGTTHSAEYQAAIRTWNETYLCRTRPWPRELTEAFANMGTEIFETMFGPSDFRIVGNVRDWDVVDRLADIAVPTLLVVGRFDECSPEHMREMQGRIAGSRLEFFESSSHMPFIEEPARFDRVMREFLRLHDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4C3</accession>
    <name>A0A7U8Y4C3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine aminotransferase</fullName>
            <ecNumber evidence="6">2.6.1.52</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphohydroxythreonine aminotransferase</fullName>
            <shortName evidence="6">PSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">serC</name>
        <name evidence="8" type="ORF">TBLG_03037</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2-oxoglutarate + 4-(phosphooxy)-L-threonine = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>2-oxoglutarate + O-phospho-L-serine = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="6">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 6">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 6">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="6"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404623.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4C3"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00311"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006272">
        <property type="entry name" value="Pser_aminoTfrase_mycobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000525">
        <property type="entry name" value="SerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01366">
        <property type="entry name" value="serC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="7">
        <location>
            <begin position="41"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="251"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="376" mass="40233" checksum="32677398E8967D1E" modified="2021-06-02" version="1">MADQLTPHLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNLVGRVRSGLAELFSLPDGYEVILGNGGATAFWDAAAFGLIDKRSLHLTYGEFSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTGVAVAVRRPEGSDDALVVIDATSGAGGLPVDIAETDAYYFAPQKNFASDGGLWLAIMSPAALSRIEAIAATGRWVPDFLSLPIAVENSLKNQTYNTPAIATLALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTPFVTDPGLRSQVVGTIDFVDDVDAGTVAKILRANGIVDTEPYRKLGRNQLRVAMFPAVEPDDVSALTECVDWVVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4F8</accession>
    <name>A0A7U8Y4F8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="175" mass="18710" checksum="EBDAA7AB4AFDD53A" modified="2021-06-02" version="1">MGPPHRSRPPLPSPGPTCQVLPTTAVIHTVTAEALGRIGIDAPRIPGSLDVAAHAAIGLLPLVAGCDRRHRRPVRGARAGRAAQVSLCMTAIRVEPVSSNAVCTGPAAQVGDQSRSPQRDYAHQTLQPDVPRRRARRHRPRRCSAKTGSSSSTMRCTCHQNQCLWSSGVSWALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4G2</accession>
    <name>A0A7U8Y4G2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_02904</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="256"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="485" mass="52032" checksum="C6C20F1061AE847B" modified="2021-06-02" version="1">MARHLRGRLPLRVRLVAATLILVATGLVASGIAVTSMLQHRLTSRIDRVLLEEAQIWAQITLPLAPDPYPGHNPDRPPSRFYVRVISPDGQSYTALNDNTAIPAVPANNDVGRHPTTLPSIGGSKTLWRAVSVRASDGYLTTVAIDLADVRSTVRSLVLLQVGIGSAVLVVLGVAGYAVVRRSLRPLAEFEQTAAAIGAGQLDRRVPQWHPRTEVGRLSLALNGMLAQIQRAVASAESSAEKARDSEDRMRQFITDASHELRTPLTTIRGFAELYRQGAARDVGMLLSRIESEASRMGLLVDDLLLLARLDAHRPLELCRVDLLALASDAAHDARAMDPKRRITLEVLDGPGTPEVLGDESRLRQVLRNLVANAIQHTPESADVTVRVGTEGDDAILEVADDGPGMSQEDALRVFERFYRADSSRARASGGTGLGLSIVDSLVAAHGGAVTVTTALGEGCCFRVSLPRVSDVDQLSLTPVVPGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4K2</accession>
    <name>A0A7U8Y4K2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4K2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="157" mass="17649" checksum="1C4B6C00917999C2" modified="2021-06-02" version="1">MIANLVAVAIRASREVVIEAPPEVIVEALADMDAVPSWSSVHKRVEVVDTYSDGRPHHVKVTIKVAGIVDTELLEYHWGPDWVVWDAAKTAQQHGQHGEYNLRREDNDKTRVRFTLTVEPSAPLPAFWVNIARKKILHAATEGLRKQVVGRRRFTSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4K8</accession>
    <name>A0A7U8Y4K8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="286" mass="32190" checksum="27113756E430CA88" modified="2021-06-02" version="1">MQSGPHLVGRVGTSFPLIARHQGATRDDAGDTGQPDPLPHVAHPDRLYPPMVHGVDPSTLALDRALNETRTGDLWLFRGRSRPDRAIQTLTNAPVNHVGMTVAIDDLPPLIWHAELGDKLLDVWTGTNHRGVQLNDARQVVQQWAGRYRQRCWLRQLTPHANRDQEDKLLRVIARMNGTPFPTTARLTGRWLRGRLPTLNDWLRGIPVLDRKVREQTQRRKQQQRTMGLATAYCAETVAITYEEMGLLVTDKDAHWFDPGKFWSGDSLPLAPGYRLGHEIAVDVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4U3</accession>
    <name>A0A7U8Y4U3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898842.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4U3"/>
    <dbReference type="GeneID" id="45425340"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019919">
        <property type="entry name" value="Lucif-like_OxRdtase_MSMEG_2256"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03617">
        <property type="entry name" value="F420_MSMEG_2256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="340" mass="37252" checksum="F4D3BCA7C5AC0767" modified="2021-06-02" version="1">MGGARRLKLDGSIPNQLARAADAAVALERNGFDGGWTAEASHDPFLPLLLAAEHTSRLELGTNIAVAFARNPMIVANVGWDLQTYSKGRLILGLGTQIRPHIEKRFSMPWGHPARRMREFVAALRAIWLAWQDGTKLCFEGEFYTHKIMTPMFTPEPQPYPVPRVFIAAVGEAMTEMCGEVADGHLGHPMVSKRYLTEVSVPALLRGLARSGRDRSAFEVSCEVMVATGADDAELAAACTATRKQIAFYGSTPAYRKVLEQHGWGDLHPELHRLSKLGEWEAMGGLIDDEMLGAFAVVGPVDTIAGALRNRCEGVVDRVLPIFMAASQECINAALQDFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4V6</accession>
    <name>A0A7U8Y4V6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="7">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406185.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4V6"/>
    <dbReference type="GeneID" id="45425149"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000813">
        <property type="entry name" value="7Fe_ferredoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00354">
        <property type="entry name" value="7FE8SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="108" mass="11839" checksum="0B5B5515F020447C" modified="2021-06-02" version="1">MTYTIAEPCVDIKDKACIEECPVDCIYEGARMLYIHPDECVDCGACEPVCPVEAIFYEDDVPEQWSHYTQINADFFAELGSPGGAAKVGMTENDPQAVKDLAPQSEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7K4</accession>
    <name>A0A7U8Y7K4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417219.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7K4"/>
    <dbReference type="GeneID" id="45427299"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="PTHR12935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="SSF110857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="159" mass="17489" checksum="F24BA2F064A4E48F" modified="2021-06-02" version="1">MPLYAAYGSNMHPEQMLERAPHSPMAGTGWLPGWRLTFGGEDIGWEGALATVVEDPDSKVFVVLYDMTPADEKNLDRWEGSEFGIHQKIRCRVERISSDTTTDPVLAWLYVLDAWEGGLPSARYLGVMADAAEIAGAPSDYVHDLRTRPARNIGPGTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7K7</accession>
    <name>A0A7U8Y7K7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase hydrophobic membrane anchor subunit sdhD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03958</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417269.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7K7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="144" mass="16901" checksum="6B2A2FE04CB8F31C" modified="2021-06-02" version="1">MSAPVRQRSHDRPASLDNPRSPRRRAGMPNFEKFAWLFMRFSGVVLVFLAIGHLFIMLMWDNGVYRLDFNFVAQRWASPFWQTWDLLLLWLAQLHGGNGLRTIIDDYSRKDTTRFWLNSLLVLSMLFTLMLGTYVIVTFDPNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7T4</accession>
    <name>A0A7U8Y7T4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="9">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 9">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415946.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7T4"/>
    <dbReference type="GeneID" id="45427036"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="10">
        <location>
            <begin position="23"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD14765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="573" mass="63673" checksum="9B0F91666F482BEE" modified="2021-06-02" version="1">MTAEAPPLGELEAIRPYPARTGPKGSLVYKLITTTDHKMIGIMYCVACISFFFIGGLLALLMRTELAAPGLQFLSNEQFNQLFTMHGTIMLLFYATPIVFGFANLVLPLQIGAPDVAFPRLNAFSFWLFVFGATIGAAGFITPGGAADFGWTAYTPLTDAIHSPGAGGDLWIMGLIVAGLGTILGAVNMITTVVCMRAPGMTMFRMPIFTWNIMVTSILILIAFPLLTAALFGLAADRHLGAHIYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIVSEIFPVFSRKPIFGYTTLVYATLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMWKGQLTFETPMLFSVGFMVTFLLGGLTGVLLASPPLDFHVTDSYFVVAHFHYVLFGTIVFATFAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQHWLGDEGMPRRYADYLPTDGFQGLNVVSTIGAFILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIRSERPAFELHYPHMVERLRAEAHVGRHHDEPAMVTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7U4</accession>
    <name>A0A7U8Y7U4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416050.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="118" mass="13751" checksum="3D89E1C43C5E88F4" modified="2021-06-02" version="1">MVRETRVRVARVYEDIDPDDGQRVLVDRIWPHGIRKDDQRVGIWCKDVAPSKELREWYHHQPERFDEFASRYQEELHDSAALAELRKLTGRSVVTPVTATRHVARSHAAVLAQLLNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Z0</accession>
    <name>A0A7U8Y7Z0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved alanine and valine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416876.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7Z0"/>
    <dbReference type="GeneID" id="45427205"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="407" mass="42506" checksum="41DC48DF9F09C48F" modified="2021-06-02" version="1">MVKPERRTKTDIAAAATIAVVVAVAASLIWWTSDARATISRPAAVAVPTPAPAREVPTSLKQLWTAASPATRVPVVVGGTVATGDGRQVDGRDPATGESLWSYARDTDLCGVTWVYHYAVAVYRYDRGCGQVSTIDGSTGRRGAARSGYADPRVRLFSDGTTVLSAGDTRLELWRSDMVRMLAYGEIDARVKPSNRGLQSGCTLESAAASSAAVSVLEACTNQADLRLVLLRPGKEDDEPIQRIVPEPGVRPGSGARVLVVSQNNTAVYLPARSGAQPRVDVIDETGATVSSTLLAKPPSTSAVASRTGNLVTWWTGDALLVFDAGNLTQRYTIAAGETTAPVGPGVMMAGQLLVPVTGGIGVYDPVSGANNRYIPVTRPPSTSAVIPAVSGSRVIEQRGDTLVALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y809</accession>
    <name>A0A7U8Y809_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-alpha-D-mannose-1-phosphate guanylyltransferase manB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417097.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y809"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="359" mass="37857" checksum="4F098A4E61D16A7A" modified="2021-06-02" version="1">MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAGLPFLTHLLSRIAAAGIEHVILGTSYKPAVFEAEFGDGSALGLQIEYVTEEHPLGTGGGIANVAGKLRNDTAMVFNGDVLSGADLAQLLDFHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEKTEDPPTDQINAGCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMGTPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAAVSPGALLIGGTVVGRGAEIGPGTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIRDGVIGDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y877</accession>
    <name>A0A7U8Y877_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine racemase</fullName>
            <ecNumber evidence="3">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03976</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="3"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y877"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_C" evidence="7">
        <location>
            <begin position="274"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="3">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="3">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3 4">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600821-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="408" mass="43388" checksum="44FECA297BA7C8E2" modified="2021-06-02" version="1">MKRFWENVGKPNDTTDGRGTTSLAMTPISQTPGLLAEAMVDLGAIEHNVRVLREHAGHAQLMAVVKADGYGHGATRVAQTALGAGAAELGVATVDEALALRADGITAPVLAWLHPPGIDFGPALLADVQVAVSSLRQLDELLHAVRRTGRTATVTVKVDTGLNRNGVGPAQFPAMLTALRQAMAEDAVRLRGLMSHMVYADKPDDSINDVQAQRFTAFLAQAREQGVRFEVAHLSNSSATMARPDLTFDLVRPGIAVYGLSPVPALGDMGLVPAMTVKCAVALVKSIRAGEGVSYGHTWIAPRDTNLALLPIGYADGVFRSLGGRLEVLINGRRCPGVGRICMDQFMVDLGPGPLDVAEGDEAILFGPGIRGEPTAQDWADLVGTIHYEVVTSPRGRITRTYREAENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y8D4</accession>
    <name>A0A7U8Y8D4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="317" mass="32734" checksum="E200757102FAE9FB" modified="2021-06-02" version="1">MKLTESNRSPRTTNTTDLSGKVAVVTGAAAGLGRAEALGLARLGATVVVNDVASALDASDVVDEIGAAAADAGAKAVAVAGDISQRATADELLASAVGLGGLDIVVNNAGITRDRMLFNMSDEEWDAVIAVHLRGHFLLTRNAAAYWRDKAKDAEGGSVFGRLVNTSSEAGLVGPVGQANYAAAKAGITALTLSAARALGRYGVCANVICPRARTAMTADVFGAAPDVEAGQIDPLSPQHVVSLVQFLASPAAAEVNGQVFIVYGPQVTLVSPPHMERRFSADGTSWDPTELTATLRDYFAGRDPEQSFSATDLMHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9Y6</accession>
    <name>A0A7U8Y9Y6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y9Y6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="174" mass="17844" checksum="5073A9EE87C0359D" modified="2021-06-02" version="1">MACVRRSCDVTGTARAGIGAGADPAVVDAVAVAADDCGFATLWVGEHVVMVDRPASRYPYSRDGVIAVPAQADWLDPMIALSFAAAASSRVDVATGVLLLPEHNPVIVAKEAASLDRLSGRRLTLGVASDGPRRSSTRSECHSSGAQSAPPNTSLQCAHYGATTSHRSTATVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA22</accession>
    <name>A0A7U8YA22_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="235" mass="24878" checksum="4C083C8D8669D8D6" modified="2021-06-02" version="1">MTSLAERTVLVTGANRGMGREYVAQLLGRKVAKVYAATRNPLAIDVSDPRVIPLQLDVTDAVSVAEVADLATDVGILINNAGISRASSVLDKDTSALRGELETNLFGPLALASAFADRIAERSGAIVNVSSVLAWLPLGMSYGVSKAAMWSATESMRIELAPRGVQVVGVYVGLVDTDMGRFADAPKSDPADVVRQVLDGIEAGKEDVLADEMSRQVRASLNVPARERIARLMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA39</accession>
    <name>A0A7U8YA39_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase rhlE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416875.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA39"/>
    <dbReference type="GeneID" id="45427204"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="41"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="259"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="416"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD14944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="527" mass="56703" checksum="21D4F93D8B61A74F" modified="2021-06-02" version="1">MTAVKHTTESTFAKLGVRDEIVRALGEEGIKRPFAIQELTLPLALDGEDVIGQARTGMGKTFAFGVPLLQRITSGDGTRPLTGAPRALVVVPTRELCLQVTDDLATAGKYLTAGPDTDDAAAVRRRLSVVSIYGGRPYEPQIEALRAGADVVVGTPGRLLDLCQQGHLQLGGLSVLVLDEADEMLDLGFLPDIERILRQIPADRQSMLFSATMPDPIITLARTFMVRPTHIRAEAPHSSAVHDATEQFVYRAHALDKVELVSRVLQARDRGATMIFTRTKRTAQKVADELTERGFAVGAVHGDLGQLAREKALKAFRTGGIDVLVATDVAARGIDIDDVTHVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELPRWSMIDQALGLGSPDPAETYSNSPHLYAELAIPATAGGTVGPARKSQGRRRDTDCDGQKTAQHARNTPRRRRTRGGKPVTGHPGTNPISSPIVGGDATSEPGSGTASDSGSDVVSGSRSGNGEAARRRRRRRRRPTHAQDGFAARAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA68</accession>
    <name>A0A7U8YA68_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">dTDP-rha:a-D-glcnac-diphosphoryl polyprenol, a-3-L-rhamnosyl transferase wbbL1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901582.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="301" mass="33295" checksum="DA8A3AE10C1A2518" modified="2021-06-02" version="1">MVAVTYSPGPHLERFLASLSLATERPVSVLLADNGSTDGTPQAAVQRYPNVRLLPTGANLGYGTAVNRTIAQLGEMAGDAGEPWVDDWVIVANPDVQWGPGSIDALLDAASRWPRAGALGPLIRDPDGSVYPSARQMPSLIRGGMHAVLGPFWPRNPWTTAYRQERLEPSERPVGWLSGSCLLVRRSAFGQVGGFDERYFMYMEDVDLGDRLGKAGWLSVYVPSAEVLHHKAHSTGRDPASHLAAHHKSTYIFLADRHSGWWRAPLRWTLRGSLALRSHLMVRSSLRRSRRRKLKLVEGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAB6</accession>
    <name>A0A7U8YAB6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="154" mass="16867" checksum="D638FE2B36223522" modified="2021-06-02" version="1">MTGRDRRVDSDQRPPAPSWILGSHGLALLCMEVLPFIVNHVVLMKSSRIPGPTQPTVVRELVAVGEPSYTALPAGLPHHPRPQRGGSSRAAPVLVDDSMPHPGTRRCCALPQPGHQFPKPGQFRRQSWSRRSLSRAQTLSPNVEPSSLSRGHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAD3</accession>
    <name>A0A7U8YAD3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031329778" evidence="2">
        <location>
            <begin position="21"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="88" mass="9289" checksum="4433594E81CB6EB0" modified="2021-06-02" version="1">MSPVSAMNRLRLTKTSPATAFSAVAHRVELADVHARPVGPGDLSPQTPVDRGPSEHRGLPPWPVATGSNTKPIGPSRHSFKPYTATAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAE1</accession>
    <name>A0A7U8YAE1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="6 8">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">glmM</name>
        <name evidence="13" type="ORF">TBLG_04095</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="6 8"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418304.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAE1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="3"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="161"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="260"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="376"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD15201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="448" mass="45873" checksum="1A796BAC81742A04" modified="2021-06-02" version="1">MGRLFGTDGVRGVANRELTAELALALGAAAARRLSRSGAPGRRVAVLGRDPRASGEMLEAAVIAGLTSEGVDALRVGVLPTPAVAYLTGAYDADFGVMISASHNPMPDNGIKIFGPGGHKLDDDTEDQIEDLVLGVSRGPGLRPAGAGIGRVIDAEDATERYLRHVAKAATARLDDLAVVVDCAHGAASSAAPRAYRAAGARVIAINAEPNGRNINDGCGSTHLDPLRAAVLAHRADLGLAHDGDADRCLAVDANGDLVDGDAIMVVLALAMKEAGELACNTLVATVMSNLGLHLAMRSAGVTVRTTAVGDRYVLEELRAGDYSLGGEQSGHIVMPALGSTGDGIVTGLRLMTRMVQTGSSLSDLASAMRTLPQVLINVEVVDKATAAAAPSVRTAVEQAAAELGDTGRILLRPSGTEPMIRVMVEAADEGVAQRLAATVADAVSTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAF6</accession>
    <name>A0A7U8YAF6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha,alpha-trehalose-phosphate synthase (ADP-forming)</fullName>
            <ecNumber evidence="6">2.4.1.347</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_04140</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ADP-alpha-D-glucose + D-glucose 6-phosphate = ADP + alpha,alpha-trehalose 6-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53880"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.347"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53884"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:137927"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-glucose 6-phosphate + GDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:62230"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate + TDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + H(+) + TDP</text>
            <dbReference type="Rhea" id="RHEA:53888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="ChEBI" id="CHEBI:61417"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="ChEBI" id="CHEBI:137931"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.347" evidence="6"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAF6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="PTHR10788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="500" mass="55877" checksum="B79269D3A64B30DC" modified="2021-06-02" version="1">MAPSGGQEAQICDSETFGDSDFVVVANRLPVDLERLPDGSTTWKRSPGGLVTALEPVLRRRRGAWVGWPGVNDDGAEPDLHVLDGPIIQDELELHPVRLSTTDIAQYYEGFSNATLWPLYHDVIVKPLYHREWWDRYVDVNQRFAEAASRAAAHGATVWVQDYQLQLVPKMLRMLRPDLTIGFFLHIPFPPVELFMQMPWRTEIIQGLLGADLVGFHLPGGAQNFLILSRRLVGTDTSRGTVGVRSRFGAAVLGSRTIRVGAFPISVDSGALDHAARDRNIRRRAREIRTELGNPRKILLGVDRLDYTKGIDVRLKAFSELLAEGRVKRDDTVLVQLATPSRERVESYQTLRNDIERQVGHINGEYGEVGHPVVHYLHRPAPRDELIAFFVASDVMLVTPLRDGMNLVAKEYVACRSDLGGALVLSEFTGAAAELRHAYLVNPHDLEGVKDGIEEALNQTEEAGRRRMRSLRRQVLAHDVDRWAQSFLDALAGAHPRGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF41</accession>
    <name>A0A7U8TF41_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402939.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF41"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011777">
        <property type="entry name" value="Geranylgeranyl_Rdtase_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02032">
        <property type="entry name" value="GG-red-SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="408" mass="43870" checksum="B2F61E46A656EA8C" modified="2021-06-02" version="1">MSVDDSADVVVVGAGPAGSAAAAWAARAGRDVLVIDTATFPRDKPCGDGLTPRAVAELHQLGLGKWLADHIRHRGLRMSGFGGEVEVDWPGPSFPSYGSAVARLELDDRIRKVAEDTGARMLLGAKAVAVHHDSSRRVVSLTLADGTEVGCRQLIVADGARSPLGRKLGRRWHRETVYGVAVRGYLSTAYSDDPWLTSHLELRSPDGAVLPGYGWIFPLGNGEVNIGVGALSTSRRPADLALRPLISYYTDLRRDEWGFTGQPRAVSSALLPMGGAVSGVAGSNWMLIGDAAACVNPLNGEGIDYGLETGRLAAELLDSRDLARLWPSLLADRYGRGFSVARRLALLLTFPRFLPTTGPITMRSTALMNIAVRVMSNLVTDDDRDWVARVWRGGGQLSRLVDRRPPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF43</accession>
    <name>A0A7U8TF43_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">o-succinylbenzoate synthase</fullName>
            <shortName evidence="5">OSB synthase</shortName>
            <shortName evidence="5">OSBS</shortName>
            <ecNumber evidence="5">4.2.1.113</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-(2'-carboxyphenyl)-4-oxybutyric acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">o-succinylbenzoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">menC</name>
        <name evidence="7" type="ORF">TBLG_02681</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10196"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18325"/>
            <dbReference type="ChEBI" id="CHEBI:58689"/>
            <dbReference type="EC" id="4.2.1.113"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.113" evidence="5"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402923.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF43"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00165"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00470">
        <property type="entry name" value="MenC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010196">
        <property type="entry name" value="OSB_synthase_MenC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041338">
        <property type="entry name" value="OSBS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18374">
        <property type="entry name" value="Enolase_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 5" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MR_MLE" evidence="6">
        <location>
            <begin position="87"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="326" mass="33975" checksum="422999B373336667" modified="2021-06-02" version="1">MIPVLPPLEALLDRLYVVALPMRVRFRGITTREVALIEGPAGWGEFGAFVEYQSAQACAWLASAIETAYCAPPPVRRDRVPINATVPAVAAAQVGEVLARFPGARTAKVKVAEPGQSLADDIERVNAVRELVPMVRVDANGGWGVAEAVAAAAALTADGPLEYLEQPCATVAELAELRRRVDVPIAADESIRKAEDPLAVVRAQAADIAVLKVAPLGGISALLDIAARIAVPVVVSSALDSAVGIAAGLTAAAALPELDHACGLGTGGLFEEDVAEPAAPVDGFLAVARTTPDPARLQALGAPPQRRQWWIDRVKACYSLLVPSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF84</accession>
    <name>A0A7U8TF84_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF84"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="855" mass="92753" checksum="8E14A443A3DC6D3B" modified="2021-06-02" version="1">MAEAFDATQAVARILAEHGPLSEDDIARRLLDSGVADPDAVLRALRLETEWPARQLVDDRWVWLPTLLAGRVFTHRLGADEAVHDMLGVTPDLDPITTLCEHEEYGRLADGSAARIVLAGYDEELLERRGIPDEAIDPGGALLLEPGTLATLGAAAGDLVGVRLTAAGLVLERIGTAGADTSVGARLAELVDPDEPAFFPAAVWTACVDDPAAFTEPVAPLREILDQHGLTHEDDWLAPGGFNFDAWRFENRCELLAFRHDLDPNDAVALYTLIKLHETMSLLLEATDPDELPRDVLATAAETATETGSDSLVDLLGDIGAALADPLLAELLVAETVGTDSGGAAALGLLTEMLEPKVPRAARVAVRWLRAVALDRIGDVEAAERELLAAESMDTEWPLPLLDLARIASDRGDAERGLALLRRAGTEPDHPLVRLLERHRAQPRRDLGRNEACWCGSGRKYKKCHLGREALPLAERVDWLYAKASQHALSGDWTGLLAEVSYERFRYADSDDEDALAAALADPLVLDAVLFEGGAFAEFLEVRGSLLPDDERLLAEQWLLVERSVFEVEHVQPGEGVIVRDVRTGDTHEVHERAASRQLRAGQLICARPVPAGDTMVFFGGIEPVALHERAVLIELLDDEPDPVTLVAQLSRRFAPPTLVNTEGDSLAICEASVRVDDPAGIQGALDGVYDRVDGEEPPRWIEHVTNDGMLRVRATLVLDGDTLRVETNSEPRMDRVLATLTRLDPAMTVLDDDRRPLRNTREAAALAEQMPVTGAGAPDPDSPELAAALEEFIRDYETSWLDQPIPALDGHTPRQAADDPTRRADLIKLLDTFPAGAGARGGMDADRLRTALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFA0</accession>
    <name>A0A7U8TFA0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplK</name>
        <name evidence="11" type="ORF">TBLG_02777</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="6 8">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403291.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFA0"/>
    <dbReference type="GeneID" id="45424600"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0488">Methylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11_N" evidence="10">
        <location>
            <begin position="11"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L11" evidence="9">
        <location>
            <begin position="73"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="142" mass="15003" checksum="6601A28FC4581455" modified="2021-06-02" version="1">MAPKKKVAGLIKLQIVAGQANPAPPVGPALGQHGVNIMEFCKAYNAATENQRGNVIPVEITVYEDRSFTFTLKTPPAAKLLLKAAGVAKGSAEPHKTKVAKVTWDQVREIAETKKTDLNANDVDAAAKIIAGTARSMGITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFA4</accession>
    <name>A0A7U8TFA4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018905">
        <property type="entry name" value="A-galactase_NEW3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10633">
        <property type="entry name" value="NPCBM_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NPCBM_assoc" evidence="1">
        <location>
            <begin position="75"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="282" mass="29940" checksum="A527CEDB5B77FEC1" modified="2021-06-02" version="1">VHRPARLSGRHRAGPARRGPLIWLTCWRPTTWRWRRTPRPLSRSTRAIGCTTRGPAPLGGLPAVAHLHPRRVRGQPGDDVVLRLTAASDCTDSVLGGVVDVVCPLGWPATPARLPFTLGAGAHLQADIALSIPAGAPPGPYPVRAQLRVVDTAVPAAWRQVVEDVCVVTVGADSDLEELVYLVDGPADIELAAGDRARLAVTIGSRAHAELALDAHSISPWGTWEWIGPPALGAVLPARGMAKLAFDVTPPAWLEPGQWWALVRVGCAGQLVYSPAVKVSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFD2</accession>
    <name>A0A7U8TFD2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="124" mass="13369" checksum="0E7F2E893AACA007" modified="2021-06-02" version="1">MFDSAAAITNPGHAWASAMERSGLLECAAGLDEQPFGEFTADKLNPDRGSSRRVPRRQADGGIATHVERGGGQRQSGGQAGVVPQRMHGFPALAMQDRLIHHGEQTQNRIAQAFRVRFCVCSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFE6</accession>
    <name>A0A7U8TFE6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplC</name>
        <name evidence="8" type="ORF">TBLG_02845</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403579.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFE6"/>
    <dbReference type="GeneID" id="45424666"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="217" mass="23090" checksum="420D4FCD7530FB84" modified="2021-06-02" version="1">MARKGILGTKLGMTQVFDESNRVVPVTVVKAGPNVVTRIRTPERDGYSAVQLAYGEISPRKVNKPLTGQYTAAGVNPRRYLAELRLDDSDAATEYQVGQELTAEIFADGSYVDVTGTSKGKGFAGTMKRHGFRGQGASHGAQAVHRRPGSIGGCATPARVFKGTRMAGRMGNDRVTVLNLLVHKVDAENGVLLIKGAVPGRTGGLVMVRSAIKRGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFI4</accession>
    <name>A0A7U8TFI4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HIT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFI4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="67"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="110" mass="11959" checksum="0C2BBCA7CD55A1DE" modified="2021-06-02" version="1">MAFLTIEPMTQGHTLVVPRAEIDHWQNVDPALFGRVMSVSQLIGKAVCRAFSTQRAGMIIAGLEVPHLHIHVFPTRSLSDFGFANVDRNPSPGSLDEAQAKIRAALAQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFM8</accession>
    <name>A0A7U8TFM8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxynitrite isomerase</fullName>
            <ecNumber evidence="5">5.99.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Ferric nitrobindin</fullName>
            <shortName evidence="5">Nb(III)</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_02959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>peroxynitrite = nitrate</text>
            <dbReference type="Rhea" id="RHEA:63116"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:25941"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="5">Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Nitrogen metabolism.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrobindin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.99.-.-" evidence="5"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898596.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFM8"/>
    <dbReference type="GeneID" id="45424776"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062213">
        <property type="term" value="F:peroxynitrite isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07828">
        <property type="entry name" value="lipocalin_heme-bd-THAP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01297">
        <property type="entry name" value="nitrobindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022939">
        <property type="entry name" value="Nb(III)_bact/plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045165">
        <property type="entry name" value="Nitrobindin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014878">
        <property type="entry name" value="THAP4-like_heme-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15854">
        <property type="entry name" value="PTHR15854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08768">
        <property type="entry name" value="THAP4_heme-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="SSF50814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THAP4_heme-bd" evidence="6">
        <location>
            <begin position="65"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXWXGXG" evidence="5">
        <location>
            <begin position="73"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="226" mass="23900" checksum="9EC0562C72F22495" modified="2021-06-02" version="1">MSSGAGSDATGAGGVHAAGSGDRAVAAAVERAKATAARNIPAFDDLPVPADTANLREGADLNNALLALLPLVGVWRGEGEGRGPDGDYRFGQQIVVSHDGGDYLNWESRSWRLTATGDYQEPGLREAGFWRFVADPYDPSESQAIELLLAHSAGYVELFYGRPRTQSSWELVTDALARSRSGVLVGGAKRLYGIVEGGDLAYVEERVDADGGLVPHLSARLSRFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFP7</accession>
    <name>A0A7U8TFP7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_02995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404384.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFP7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016624">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="E1_dh" evidence="6">
        <location>
            <begin position="42"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="334" mass="35757" checksum="483DD0BA07DE9DA4" modified="2021-06-02" version="1">MTRTSEGLAAFVVDQLEELYRRMWVLRLLDMALEQLRIEGLINGPLQGGFGQEAVSVGAAAALGEGDVIITTHRPHAQHVGTDAPLGPVIADMLGATAGDLEGADEDAHIADPRAGLPAAIRVVKQSPLLAIGHAYALWLRDTGRVTLCVTQDCDVDADAFNEAADLAAVWQLPVVILVENIRGALSVHLDRYTHEPRVYRRAVAYGMPGVSVDGNDVEAVRDCVANAVVRARAGGGPTLVQAITYRTTDFSGSDRGGYRDLAGSEQFLDPLIFARRRLIAAGTTRGRLDEQERAACQQVADAVAFAKARARPNGGGPISRPTSGWHQQPKTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFS4</accession>
    <name>A0A7U8TFS4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipoprotein lpqQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02983</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404362.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFS4"/>
    <dbReference type="GeneID" id="45424801"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030566417" evidence="4">
        <location>
            <begin position="28"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PknH_C" evidence="5">
        <location>
            <begin position="36"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="214" mass="22903" checksum="D3E46247C1ABA39C" modified="2021-06-02" version="1">MCCSTAAKSAVIVCCAAIATTACSFQATSTQPSTAPPTSRVDSLIVSIEDVRRIANYEELAAHFQTDLREPPEADTNVPGPCRVVGSSDRTFGTDWSEFRSAGYHGVTDDLRPGGPVMVETVSQAIALYPDPSTARGVFHRLESSLAECAGLHDPYFDFILDRPDASTVRIGAAGWSHVYRLKSSVFISVGVLGIEPAEPIANVILQTISDRIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFX6</accession>
    <name>A0A7U8TFX6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFX6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030868789" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="32"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="46"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="54"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="370" mass="37848" checksum="36151162549B3B58" modified="2021-06-02" version="1">MKFARSGAAVSLLAAGTLVLTACGGGTNSSSSGAGGTSGSVHCGGKKELHSSGSTAQENAMEQFVYAYVRSCPGYTLDYNANGSGAGVTQFLNNETDFAGSDVPLNPSTGQPDRAAERCGSPAWDLPTVFGPIAITYNIKGVSTLNLDGPTTAKIFNGTITVWNDPQIQALNSGTDLPPTPISVIFRSDKSGTSDNFQKYLDGASNGAWGKGASETFNGGVGVGASGNNGTSALLQTTDGSITYNEWSFAVGKQLNMAQIITSAGPDPVAITTESVGKTIAGAKIMGQGNDLVLDTSSFYRPTQPGSYPIVLATYEIVCSKYPDATTGTAVRAFMQAAIGPGQEGLDQYGSIPLPKSFQAKLAAAVNAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG46</accession>
    <name>A0A7U8TG46_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator kdpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="60"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="60"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="159" mass="17613" checksum="721DCB2949D2A429" modified="2021-06-02" version="1">MAGLTAPVIVLSARTDSSDKVQALDAGADDYVTKPFGMDEFLARLRAAVRRNTAAAELEQPVIETDSFTVDLAGKKVIKDGAEVHLTPTEWGMLEMLARNRGKLVGRGELLKEVWGPAYATETHYLRVYLAQLRRKLEDDPSHPKHLLTESGMGYRFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG69</accession>
    <name>A0A7U8TG69_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_1" evidence="2">
        <location>
            <begin position="118"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="287" mass="31402" checksum="3DE32093E1DC7A8B" modified="2021-06-02" version="1">MRASPADGLAITGLSWKGSRGGSVREVRGGTCPLSSGRGKRCGSAITVGRWMVPATRCSPTLPRCSGWTLRWPRISRSCCRWIPRTCGHTSIRRAPARTRSPQGALSNYKKSADEPDDHAIGRSRGGLTTKIHALTDQREAPVRIRLTAGQAGDNPQLLPLLDDYRHASTEYALGSTDFRLLADKAYSHPSTRAALRSKKIKHTIPERQDQIDRRKAKGSAGGRPPAFDAALYGLRNTVERGFHRLKQWRGIATRYDKYALTYLGGVLLACAVIHARVGTPKLGDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG77</accession>
    <name>A0A7U8TG77_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Beta-ketoacyl CoA thiolase fadA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03244</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="281"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="405" mass="42625" checksum="7553D7D013E60623" modified="2021-06-02" version="1">MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALNPHQIDDLMMGCGLPGGESGFNIARVVAVALGYDFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVEAVSRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVAIMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVSTDDGPRPGTTYEKVSELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIMGLGPIEASKKALERAGMAITDIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGHPFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG93</accession>
    <name>A0A7U8TG93_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fumarate hydratase class II</fullName>
            <shortName evidence="3">Fumarase C</shortName>
            <ecNumber evidence="3">4.2.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Aerobic fumarase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Iron-independent fumarase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fumC</name>
        <name evidence="6" type="ORF">TBLG_03272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="3"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405805.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG93"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045239">
        <property type="term" value="C:tricarboxylic acid cycle enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="PTHR11444"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lyase_1" evidence="4">
        <location>
            <begin position="18"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="5">
        <location>
            <begin position="408"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="104"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding (B site)" evidence="3">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="474" mass="50141" checksum="4052F93F963D3DBB" modified="2021-06-02" version="1">MAVDADSANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGLERTQIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAKGGVTLHPNDDVNMSQSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGB3</accession>
    <name>A0A7U8TGB3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="123" mass="12914" checksum="ACCD191F6CAD0C24" modified="2021-06-02" version="1">GGVVEYRDNVMVITINRPEARNAVNGAVSIVVGDALEEAHDNPDVRAVVITGAGDKSLCAGADLKAIARRENPYHPHHGEWGIAGYRHHFIDKPTSAAVSGTALDDGAEPALASDLVVADEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGD8</accession>
    <name>A0A7U8TGD8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406047.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGD8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="15"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="121" mass="13114" checksum="E869C22997DA5CE3" modified="2021-06-02" version="1">MELRDWLRVDVKAGKPLFDQLRTQVIDGVRAGALPPGTRLPTVRDLAGQLGVAANTVARAYRELESAAIVETRGRFGTFISRFDPTDAAMAAAAKEYVGVARALGLTKSDAMRYLTHVPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGM1</accession>
    <name>A0A7U8TGM1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="3">DAP decarboxylase</shortName>
            <shortName evidence="3">DAPDC</shortName>
            <ecNumber evidence="3 4">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lysA</name>
        <name evidence="7" type="ORF">TBLG_03475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="3 4"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406632.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGM1"/>
    <dbReference type="GeneID" id="45425267"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3 4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="6">
        <location>
            <begin position="48"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="5">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="3">
        <location>
            <begin position="300"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="447" mass="47458" checksum="3CE085A33F7F30F4" modified="2021-06-02" version="1">MNELLHLAPNVWPRNTTRDEVGVVCIAGIPLTQLAQEYGTPLFVIDEDDFRSRCRETAAAFGSGANVHYAAKAFLCSEVARWISEEGLCLDVCTGGELAVALHASFPPERITLHGNNKSVSELTAAVKAGVGHIVVDSMTEIERLDAIAGEAGIVQDVLVRLTVGVEAHTHEFISTAHEDQKFGLSVASGAAMAAVRRVFATDHLRLVGLHSHIGSQIFDVDGFELAAHRVIGLLRDVVGEFGPEKTAQIATVDLGGGLGISYLPSDDPPPIAELAAKLGTIVSDESTAVGLPTPKLVVEPGRAIAGPGTITLYEVGTVKDVDVSATAHRRYVSVDGGMSDNIRTALYGAQYDVRLVSRVSDAPPVPARLVGKHCESGDIIVRDTWVPDDIRPGDLVAVAATGAYCYSLSSRYNMVGRPAVVAVHAGNARLVLRRETVDDLLSLEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGM9</accession>
    <name>A0A7U8TGM9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide-transport membrane protein ABC transporter oppC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03463</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406607.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425254"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="81"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="291" mass="31374" checksum="F6BB51906154CF9F" modified="2021-06-02" version="1">MTEFASRRTLVVRRFLRNRAAVASLAALLLLFVSAYALPPLLPYSYDDLDFNALLQPPGTKHWLGTNALGQDLLAQTLRGMQKSMLIGVCVAVISTGIAATVGAISGYFGGWRDRTLMWVVDLLLVVPSFILIAIVTPRTKNSANIMFLVLLLAGFGWMISSRMVRGMTMSLREREFIRAARYMGVSSRRIIVGHVVPNVASILIIDAALNVAAAILAETGLSFLGFGIQPPDVSLGTLIADGTASATAFPWVFLFPASILVLILVCANLTGDGLRDALDPASRSLRRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGP9</accession>
    <name>A0A7U8TGP9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403128.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="20"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="213"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="411" mass="44694" checksum="3C2CCD98EE43F4C0" modified="2021-06-02" version="1">MGVVERAIAPSVLAALADTPVVVVNGARQVGKTTLVARLDYPGSSEVVSLDDVANRDAARDDPRAFVSRPVDTLVIDEAQLEPGLFRAIKAEVDRDRRPGRFLLTGSARLLSAPDMADALVGRVEIIELWPFSQGERAGIADGFVDALFTAPRELIHGSDMRRADLVDRIATGGFPDIVARSPSRRRAWFDNYLTTATQSVIREISPIERLAEMPRVLRLCAARTGAELNVSALANDLSIPARTTAGYLALLEAAFLIHRVPAWSTNLSRKVIRRPKLVVSDSGLACHLLGVTGATLDRPGRPLGPLLETFVANEIRKQLTWSTERPSLWHFRDRGGAEVDLVLEHPDGRVCGIEVKATSTPRAEDLRGLRYLAERLDDRFQFGVLLTAAPEATPFGPTLAALPVSTLWAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGR0</accession>
    <name>A0A7U8TGR0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031204178" evidence="1">
        <location>
            <begin position="29"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="111" mass="11589" checksum="98FC7A294E07D8A3" modified="2021-06-02" version="1">MRRRPLFLTAAVSSVAISLRRAAGTAFEIEVDMPTSLAGNGVDLGAAIEVAGTFALETQRRVPDDGPFDELVAPASHALLVGHDASPSLRLARLRPALDAQEIHGAAASFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGR5</accession>
    <name>A0A7U8TGR5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GGDEF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898837.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGR5"/>
    <dbReference type="GeneID" id="45425333"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="212"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="354"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="623" mass="67653" checksum="ED54E5FA997191B7" modified="2021-06-02" version="1">MCNDTATPQLEELVTTVANQLMTVDAATSAEVSQRVLAYLVEQLGVDVSFLRHNDRDRRATRLVAEWPPRLNIPDPDPLRLIYFADADPVFALCEHAKEPLVFRPEPATEDYQRLIEEARGVPVTSAAAVPLVSGEITTGLLGFIKFGDRKWHEAELNALMTIATLFAQVQARVAAEARLRYLADHDDLTGLHNRRALLQHLDQRLAPGQPGPVAALFLDLDRLKAINDYLGHAAGDQFIHVFAQRIGDALVGESLIARLGGDEFVLIPASPMSADAAQPLAERLRDQLKDHVAIGGEVLTRTVSIGVASGTPGQHTPSDLLRRADQAALAAKHAGGDSVAIFTADMSVSGELRNDIELHLRRGIESDALRLVYLPEVDLRTGDIVGTEALVRWQHPTRGLLAPGCFIPVAESINLAGELDRWVLRRACNEFSEWQSAGLGHDALLRINVSAGQLVTGGFVDFVADTIGQHGLDASSVCLEITENVVVQDLHTARATLARLKEVGVHIAIDDFGTGYSAISLLQTLPIDTLKIDKTFVRQLGTNTSDLVIVRGIMTLAEGFQLDVVAEGVETEAAARILLDQRCYRAQGFLFSRPVPGEAMRHMLSARRLPPTCIPATDPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGT1</accession>
    <name>A0A7U8TGT1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ORF">TBLG_03566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407200.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGT1"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="159"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="319" mass="33819" checksum="3D1F8C52A48F95AA" modified="2021-06-02" version="1">MTPRHLLTAADLSRDDATAILDDADRFAQALVGRDIKKLPTLRGRTVVTMFYENSTRTRVSFEVAGKWMSADVINVSAAGSSVGKGESLRDTALTLRAAGADALIIRHPASGAAHLLAQWTGAHNDGPAVINAGDGTHEHPTQALLDALTIRQRLGGIEGRRIVIVGDILHSRVARSNVMLLDTLGAEVVLVAPPTLLPVGVTGWPATVSHDFDAELPAADAVLMLRVQAERMNGGFFPSVREYSVRYGLTERRQAMLPGHAVVLHPGPMVRGMEITSSVADSSQSAVLQQVSNGVQVRMAVLFHVLVGAQDAGKEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGX1</accession>
    <name>A0A7U8TGX1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="171" mass="13726" checksum="2B28845FFBBB6FA4" modified="2021-06-02" version="1">AGLGGSSGPGGTPGDWGTGGTGGTGGTGGQGANGGLTGGRGGTGGNGGNGNTGGTGGAGGTGGTGHNGSQPGMGGNGGAGGFGGNGFAGVGGRGGMGGSGGTGGTGDAGPFGTGTGGTGGHGGQGGGGGFSILLGLGGLGGLGSPGSIATGTAGGAGGGGGFGGLGGGEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGX3</accession>
    <name>A0A7U8TGX3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407225.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGX3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="102" mass="9862" checksum="8165F09DBDB9D752" modified="2021-06-02" version="1">MTLRVVPESLAGASAAIEAVTARLAAAHAAAAPFIAAVIPPGSDSVSVCNAVEFSVHGSQHVAMAAQGVEELGRSGVGVAESGASYAARDALAAASYLSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGX4</accession>
    <name>A0A7U8TGX4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transketolase tkt</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03640</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD13056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="572" mass="61888" checksum="E1086B532EED1BE6" modified="2021-06-02" version="1">MTTLEEISALTRPRHPDDWTEIDSAAVDTIRVLAADAVQKVGNGHPGTAMSLAPLAYTLFQRTMRHDPSDTHWLGRDRFVLSAGHSSLTLYIQLYLGGFGLELSDIESLRTWGSKTPGHPEFRHTPGVEITTGPLGQGLASAVGMAMASRYERGLFDPDAEPGASPFDHYIYVIASDGDIEEGVTSEASSLAAVQQLGNLIVFYDRNQISIEDDTNIALCEDTAARYRAYGWHVQEVEGGENVVGIEEAIANAQAVTDRPSFIALRTVIGYPAPNLMDTGKAHGAALGDDEVAAVKKIVGFDPDKTFQVREDVLTHTRGLVARGKQAHERWQLEFDAWARREPERKALLDRLLAQKLPDGWDADLPHWEPGSKALATRAASGAVLSALGPKLPELWGGSADLAGSNNTTIKGADSFGPPSISTKEYTAHWYGRTLHFGVREHAMGAILSGIVLHGPTRAYGGTFLQFSDYMRPAVRLAALMDIDTIYVWTHDSIGLGEDGPTHQPIEHLSALRAIPRLSVVRPADANETAYAWRTILARRNGSGPVGLILTRQGVPVLDGTDAEGVARAVTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGX5</accession>
    <name>A0A7U8TGX5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGX5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD13050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="161" mass="18316" checksum="4D0A5404001C9858" modified="2021-06-02" version="1">MVGYAEPVLIERQSVVAAPAEQVWQRVVTPEGINDELRPWMTMSVPRGAKGMTVDTVPIGAPIGRAWLRLFGVLPFDYDRLSIAELEPGRRFREDSTMLSMRQWQHERTVTPEGDTKTIVRDRITFQTRAGLRFAAPLIAAGLRALFGHRHRRLQRHFAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THB9</accession>
    <name>A0A7U8THB9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, tetR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02791</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403355.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THB9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="231" mass="24727" checksum="05591A82EA789BE8" modified="2021-06-02" version="1">MTSQTGVRDELLHAGVRLLDDHGPDALQTRKVAAAAGTSTMAVYTHFGGMRGLIAAIAEEGLRQFDVALTVPQTADPVADLLAIGTAYRRYAIERPHMYRLMFGSTSAHGINVPARDVLTLKVAEIEHQHPSFAHVVRAVHRCLLAGRFATALGADDDTAIVATAAQFWSQIHGFVMLELAGFYGDRGAAVEPVLAAMTVNLLVALGDSPERAQCSLRAEQTQKNTLGRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THN3</accession>
    <name>A0A7U8THN3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="44" mass="5221" checksum="C557AD7A4730A55C" modified="2021-06-02" version="1">MTLDRHGHLLNDDLAVWPMRCAKSSRTLRYHCGMRRRNRVGLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THS8</accession>
    <name>A0A7U8THS8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THS8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="92"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="285" mass="31190" checksum="681FA6E535D2A9B7" modified="2021-06-02" version="1">MLFNAVHNSLPPNIDIDHAILRGEDHPPTCAKCVARGRISALGSLDLRYHSLRCYAAPPDVGRCEFVPPRRRVLIANQGLDVSRLPPTGTVTLLLADVEESTHLWQMCPEDMATAIAHLDHTVSEAITNHGGVQPVKRYEGDSFVAAFTRASDAAACALDLQRTSLAPIRLRIGLHTGEVQLRDELYVGPTINRTARLRDLAHGGQVVLSAATGDLVTGRLPADAWLVDLGRHPLRGLPRPEWVMQLCHPDIREKFPPLRTAKSSPTSILPAQFTTFVGRRAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THT2</accession>
    <name>A0A7U8THT2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Non-homologous end joining protein Ku</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ku</name>
        <name evidence="4" type="ORF">TBLG_03095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer. Interacts with LigD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic Ku family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404795.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THT2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00789">
        <property type="entry name" value="KU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01875">
        <property type="entry name" value="Prokaryotic_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="Ku70/Ku80_beta-barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009187">
        <property type="entry name" value="Prok_Ku"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41251">
        <property type="entry name" value="PTHR41251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006493">
        <property type="entry name" value="Prok_Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SSF100939"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02772">
        <property type="entry name" value="Ku_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ku" evidence="3">
        <location>
            <begin position="52"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="273" mass="30904" checksum="DE11166BC1C52519" modified="2021-06-02" version="1">MRAIWTGSIAFGLVNVPVKVYSATADHDIRFHQVHAKDNGRIRYKRVCEACGEVVDYRDLARAYESGDGQMVAITDDDIASLPEERSREIEVLEFVPAADVDPMMFDRSYFLEPDSKSSKSYVLLAKTLAETDRMAIVHFTLRNKTRLAALRVKDFGKREVMMVHTLLWPDEIRDPDFPVLDQKVEIKPAELKMAGQVVDSMADDFNPDRYHDTYQEQLQELIDTKLEGGQAFTAEDQPRLLDEPEDVSDLLAKLEASVKARSKANSNVPTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THT7</accession>
    <name>A0A7U8THT7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Penicillin-binding protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030524075" evidence="1">
        <location>
            <begin position="26"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="57"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3471" evidence="3">
        <location>
            <begin position="433"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="526" mass="56192" checksum="DF5CC3D0500D7256" modified="2021-06-02" version="1">MTKRAATAAMVMLLTLTGCGSTHQALGPPSGLPDASPNERSAIQIPAGRIDDAVAKVDGLVGELMQNTGIPGMAVAIVHGGKTLYAKGFGVRDVGKGGGPDNKVDADTVFQLASVSKSVGATVVAHAVTDNVVTWDTPVVSKLPWFALRDPYVTGQVTIADLYSHRSGLPDHAGDLLEDLGYDRRQVLQRLKYLPLAPFRISYAYTNFGVTAAAEAVAAAAGQSWEDLSDEVLYRPLGMGSTSSRFTDFLARPNHAVNHVKVADRWEARYQRDPDAQSPAGGVSSSLNDMTHWLAMVLADGVYNGRRITSPEALLPVYTPQVISRHPVSPRARASFYGYGFNVGVTSSGRTEYSHSGAFGLGAAANFVVLPSEDLAITALTNAGPIGVPETLTAEFMDLVQYGQVREDWAALYKKAFAPLNELAGSLVGKQSPANPAPSRPLNDYVGVYANDYWGPATVTYHDGQLRLSLGPKNQTFDLTHWDGDTFTFTLSTENALPGSISKATFAGDTLNLEYYDADKLGTFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THX7</accession>
    <name>A0A7U8THX7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="6"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="137"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="197" mass="21395" checksum="F10A56D2185D3965" modified="2021-06-02" version="1">MAIASKSALRDQLLAARRRVADDVRAAEARMLRGHLERMVTSDSTVCAYVPVGGEPGSIEMLDVLLRRAGRVLLPVARTAGGDLPLPLRWGEYRAGGLARARWGLLEPPEPWLPEAALAQASLVLVPALAVDRQGVRLGRGRGFYDRSLRCRDPHARLVAVVRTVELVDVLPSEPHDVPMTHALTPERGLIALPCGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THZ1</accession>
    <name>A0A7U8THZ1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="240" mass="26338" checksum="C96AC175F83F10A7" modified="2021-06-02" version="1">CQGRLPSRMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPCTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLIPDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKKRKGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI35</accession>
    <name>A0A7U8TI35_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF222 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898712.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="54" mass="5974" checksum="709BCC29D04E8F75" modified="2021-06-02" version="1">MRECLAMVGQVFTAGDIDYRMFQTIVCRSDLTVDGEVLAPWPPSSLSGRLAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI76</accession>
    <name>A0A7U8TI76_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03554</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI76"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="86" mass="9773" checksum="FD0FC335CA0DDC0D" modified="2021-06-02" version="1">MRPSRQGEVGEVAGYVVEYNRRTHVRRITEFATPQEAMEHRLKLEAERTDSNIEIVALVSKSLGTLKQTHSRYFTGEELNVGNGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TID6</accession>
    <name>A0A7U8TID6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PepX_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TID6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="SSF49785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00976">
        <property type="entry name" value="NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PepX_C" evidence="1">
        <location>
            <begin position="322"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="561" mass="62627" checksum="C35176E8172866AD" modified="2021-06-02" version="1">MARNPSPALDRPWRRPGALRYALERVRGVAKPPITVTDPPADVVIERDVEVPTRDGTLLRINVFRSAEGGARPVIASIHPYGKDALPRRRGNRWTFSPQYRMLRQPKPLTFSALTGWEAPDPAWWTAQGFVVVNADSRGCGRSDGTGDLLSHQEAEDTYDLVGWLADQSWSDGRVVMLGVSYLAISQYAVAALQPPALRAICPWEGFTDAYRDLAFPGGIRESGFTRLWSRGVRRRTRQTYDMEQMQEAHPLRDDFWRSRVPDLSAIKVPMLVCGSFSDNNLHSRGSIRAFTRSGCGHARLYTHRGGKWETFYSATALSEQLKFLRDALAGSSGSRSVRLEVREDRDTITAVREETQWPLAGTRWRPMYLAGPGLLATEPPPTAGSIRFQTRSRAAAFNWTIPEDIELTGPMAARLWVQLDGCDDANLFVGVEKWRDGQFVAFEGSYGWGRDRVTTGWQRVSLRELDPELSQPWEPVPACARPRPVTAGEVVAVDVALGPSATLFRAGEQLRLVVGGRWLSPRNPLTGQFPAAYPRPPRGRVTLHWGPRYDAHLLIPEVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIG4</accession>
    <name>A0A7U8TIG4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406358.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425227"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="37"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="455" mass="47270" checksum="833B5078CF3BD325" modified="2021-06-02" version="1">MNTDVLAGLMAELPEGMVVTDPAVTDGYRQDRAFDPSAGKPLAIIRPRRTEEVQTVLRWASANQVPVVTRGAGSGLSGGATALDGGIVLSTEKMRDITVDPVTRTAVCQPGLYNAEVKEAAAEHGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTGDYVLGMQVVLANGTAVRLGGPRLKDVAGLSLTKLFVGSEGTLGVITEVTLRLLPAQNASSIVVASFGSVQAAVDAVLGVTGRLRPAMLEFMDSVAINAVEDTLRMDLDRDAAAMLVAGSDERGRAATEDAAVMAAVFAENGAIDVFSTDDPDEGEAFIAARRFAIPAVESKGALLLEDVGVPLPALGELVTGIARIAEERNLMISVIAHAGDGNTHPLLVYDPADAAMLERAHLAYGEIMDLAVGLGGTITGEHGVGRLKRPWLAGYLGPDVLALNQRIKQALDPQGILNPGSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIP3</accession>
    <name>A0A7U8TIP3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019692">
        <property type="entry name" value="DUF2581"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10756">
        <property type="entry name" value="bPH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="154" mass="16383" checksum="3109AB9ABDD3296D" modified="2021-06-02" version="1">MTAAPNDWDVVLRPHWTPLFAYAAAFLIAVAHVAGGLLLKVGSSGVVFQTADQVAMGALGLVLAGAVLLFARPRLRVGSAGLSVRNLLGDRIVGWSEVIGVSFPGGSRWARIDLADDEYIPVMAIQAVDKDRAVAAMDTVRSLLARYRPDLCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIR1</accession>
    <name>A0A7U8TIR1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898881.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIR1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="136" mass="15023" checksum="F493EB61BE9E297D" modified="2021-06-02" version="1">MTVMADRSGRPAPVRRRMKTLTQAALNADKTVEQVEDVLDGLGKTMAELNSSLSQLNSTVERLEDGLDHLEGTLHSLDDLAKRLIVLVEPVEAIVDRIDYIVSLGETVMSPLSVTEHAVRGVLDRLRNRTVHEPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR35</accession>
    <name>A0A7U8TR35_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021784">
        <property type="entry name" value="DUF3349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11829">
        <property type="entry name" value="DUF3349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="124" mass="13382" checksum="22DEB3D987B658D9" modified="2021-06-02" version="1">MTKTFSHPHFFRSVLRWLQVGYPEGVPGPDRVALLSLLRSTPLTEEQIGEVVRHFTENGSPAVADRVIDRDEIAEFISEVTHHDAGPENIQRVAGILAAAGWPLAGVDVGESESGSNRAPASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR38</accession>
    <name>A0A7U8TR38_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899891.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR38"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030979">
        <property type="term" value="P:alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037090">
        <property type="entry name" value="57_glycoside_trans_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015293">
        <property type="entry name" value="BE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040042">
        <property type="entry name" value="Branching_enz_MT3115-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41695">
        <property type="entry name" value="PTHR41695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09210">
        <property type="entry name" value="DUF1957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="3">
        <location>
            <begin position="13"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1957" evidence="4">
        <location>
            <begin position="443"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="526" mass="57815" checksum="6095D375968E9589" modified="2021-06-02" version="1">MNTSASPVPGLFTLVLHTHLPWLAHHGRWPVGEEWLYQSWAAAYLPLLQVLAALADENRHRLITLGMTPVVNAQLDDPYCLNGVHHWLANWQLRAEEAASVRYARQSKSADYPSCTPEALRAFGIRECADAARALDNFATRWRHGGSPLLRGLIDAGTVELLGGPLAHPFQPLLAPRLREFALREGLADAQLRLAHRPKGIWAPECAYAPGMEVDYATAGVSHFMVDGPSLHGDTALGRPVGKTDVVAFGRDLQVSYRVWSPKSGYPGHAAYRDFHTYDHLTGLKPARVTGRNVPSEQKAPYDPERADRAVDVHVADFVDVVRNRLLSESERIGRPAHVIAAFDTELFGHWWYEGPTWLQRVLRALPAAGVRVGTLSDAIADGFVGDPVELPPSSWGSGKDWQVWSGAKVADLVQLNSEVVDTALTTIDKALAQTASLDGPLPRDHVADQILRETLLTVSSDWPFMVSKDSAADYARYRAHLHAHATREIAGALAAGRRDTARRLAEGWNRADGLFGALDARRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR50</accession>
    <name>A0A7U8TR50_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxylaminobenzene mutase hab</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416059.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR50"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="133" mass="14080" checksum="BC16B4E13211C3D0" modified="2021-06-02" version="1">MQKLLFTIGLALFLIGLLTGLVIPALKNPRMALSSHLEGVLNGMFLVVLGLLWPHIDLPEAWQVIAVALIVYSAYANWLATLLAAAWGAGRKFAPIATGDHKAPAAKEGFVSFLLLSLSVAIVIGVVIVIIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR56</accession>
    <name>A0A7U8TR56_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416053.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR56"/>
    <dbReference type="GeneID" id="45427072"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="158" mass="17122" checksum="80A62A6BD3800F8F" modified="2021-06-02" version="1">MVLDGVVSDTRRSRTIAARQQTIWDVLADFGSLSSWVEGVDHSCVLNHGPDGGALGSTRRVQVGRNTLVERVIEFDPPTTLAYRIEGLPARLRKVTNRWTLRPADPVGAVTVVTLTSTIEIGGNPLARLAELVVGRAMAKRSNTMLAGLAQRLEDKHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR67</accession>
    <name>A0A7U8TR67_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03711</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900628.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427087"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="181"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="185"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="212"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="407"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="563" mass="61645" checksum="A04DE7C1A5AAC250" modified="2021-06-02" version="1">MPIPFADGMLSRLGRRGAALDLIEEFEDESGEPPASLSPADLLAAEPALLLQKMENRLVRHHLANPDVLSGEQLRKLRYILNFARLADFEPGAAGPGGSRGRGDISVGGQVAPWRSRVVDALYAPLREEPDPVTALEGAKDVLATLVDDQDDQRRVLIERHGSDFSATELDAEVGYKKLVTVLGGGGGAGFVYIGGMQRLLAAGQVPDYMIGSSFGSIIGSLVARELPVPIDEYAEWAKTVSYRAILGPERRRSRHGLAGMFTLRFDQFAHTLLSRADGERMRMSDLAIPFDVVVAGVRRQPYAALPSRFRHRERSTLTLRSLPFLPIGIGPWVAARMWQVAAFIDLRVVKPIVISADGATRDVNVVDAASFSSAIPGVLHHETSDPRMLPILDELCADQDVAAMVDGGAASNVPVELAWERVRDGRLGTRNACYLAFDCFHPHWDPRHLWLVPITQAVQLQMVRNLPYADHLVRFEPTLSPVNLAPSAAAIDRACRWGRDSVEPAIAVTSALLEPTWWEGDRPPAAEPKERTKSAASSMSAVMAAIQAPTGRFRRWRSRHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR70</accession>
    <name>A0A7U8TR70_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899894.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="94" mass="10067" checksum="4F1AAF72D597821A" modified="2021-06-02" version="1">MGGPFDADAEAHFDEVAEAFAKLTNVDRDVGVDLEKELCMTVEADDRSDALVTRRLLPRVPRCIPLAARLAPGTIGCPSFWNPIATGGASRQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR72</accession>
    <name>A0A7U8TR72_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaC</name>
        <name evidence="7" type="ORF">TBLG_03732</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="6">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="170" mass="17844" checksum="B2B1D481145FE41A" modified="2021-06-02" version="1">MIDHALALTHIDERGAARMVDVSEKPVTLRVAKASGLVIMKPSTLRMISDGAAAKGDVMAAARIAGIAAAKRTGDLIPLCHPLGLDAVSVTITPCEPDRVKILATTTTLGRTGVEMEALTAVSVAALTIYNMCKAVDRAMEISQIVLQEKSGGRSGVYRRSASDLACQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRC3</accession>
    <name>A0A7U8TRC3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899955.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRC3"/>
    <dbReference type="GeneID" id="45427172"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039554">
        <property type="entry name" value="HigA2-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13744">
        <property type="entry name" value="HTH_37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="41"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="109" mass="11802" checksum="A66DBE160D79613A" modified="2021-06-02" version="1">MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTELGTLQAYVAALGGHLRIVAEFGENTVELTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRD5</accession>
    <name>A0A7U8TRD5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Threonine and proline rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="133" mass="14058" checksum="91E9B1ABD356F20E" modified="2021-06-02" version="1">MRPQLPPETVTTVAPPGTGPTTVPTRTPTAAPPQTAVPPPAPLNPRTVVYRVTGTKQLFDLVNVVYTDARGFPVTDFNVSLPWTKMVVLNPGVQTESVVATSLYSRLNCSIVNTGAQTVVASTNNAIIATCTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRJ9</accession>
    <name>A0A7U8TRJ9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417119.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRJ9"/>
    <dbReference type="GeneID" id="45427267"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="PTHR31937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD15012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="222" mass="23633" checksum="B9714287801D44FB" modified="2021-06-02" version="1">METTTEHRDESTLDSPVSVAREAEWQRNVRWARWLAWVSLAVLLTEGAVGLWQGIAVGSVALTGWALGGGSEGLASAMVLWRFTGDRTWSATAEHRAQRGVAVSFWLTAPYLVAESIRHLAGEHRAETSVIGIGLTAIALLLMPVLGWANHRVGERLGSGATAGEGTQNYLCAAQAAAVLLGLAITAVWSNGWWIDPAIGLAIAGIAVWQGIRTWRGHGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRK2</accession>
    <name>A0A7U8TRK2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03906</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417107.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRK2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031456286" evidence="3">
        <location>
            <begin position="33"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="95"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="366"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="498" mass="51314" checksum="B54D95E3C342CDC9" modified="2021-06-02" version="1">MMSAQRVVRTVRTARAISTALAVAIVLGTGVAWSSVRSFEDGIFHMSAPSLGHGGDDGAIDILLVGLDSRTDAHGNPLSAEELATLHAGDEEATNTDTIILIRVPNNGKSATAISIPRDSYVAAPGLGKTKINGVYGQTRETKRAGLVQAGASPTEAAAAGTEAGREALIKTVADLTGVTVDHYAEIGLLGFALIADALGGVDVCLKEPVYEPLSGADFPAGRQKLNGPQALSFVRQRHDLPRGDLDRVVRQQAVMAALAHRVISGQTLSSPATLKRLEQAVQRSVVLSSGWDIMDFVRQLQKLAGGNVAFATIPVLDGAGWSDDGMQSVVRVDPRQVQDWVVGLLHEQDQGKTDELAYTPAKTTANVVNDTDINGLAAAVSKVLSSKGFTTGSVGNNDGDHVPGSQVRAAKADDLGAQQVAKELGGLPVVADASIAPGSVRVVLANDYSGPGSGLGGSDPNGVVSPARAFNLGSADDTTPPPSPILTAGSDAPECIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRK9</accession>
    <name>A0A7U8TRK9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase sigma factor sigF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03925</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417158.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRK9"/>
    <dbReference type="GeneID" id="45427282"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014322">
        <property type="entry name" value="RNA_pol_sigma-B/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02980">
        <property type="entry name" value="SigBFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r3" evidence="5">
        <location>
            <begin position="126"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="7">
        <location>
            <begin position="209"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="261" mass="28794" checksum="7FD4AA6AB64061AB" modified="2021-06-02" version="1">MTARAAGGSASRANEYADVPEMFRELVGLPAGSPEFQRHRDKIVQRCLPLADHIARRFEGRGEPRDDLIQVARVGLVNAAVRFDVKTGSDFVSFAVPTIMGEVRRHFRDNSWSVKVPRRLKELHLRLGTATADLSQRLGRAPSASELAAELGMDRAEVIEGLLAGSSYHTLSIDSGGGSDDDARAITDTLGDVDAGLDQIENREVLRPLLEALPERERTVLVLRFFDSMTQTQIAERVGISQMHVSRLLAKSLARLRDQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRL1</accession>
    <name>A0A7U8TRL1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphatase</fullName>
            <ecNumber evidence="2">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="2">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:44644"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:65317"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23996"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Maf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="2"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417146.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRL1"/>
    <dbReference type="GeneID" id="45427278"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="222" mass="23010" checksum="C9E25348F3A96A26" modified="2021-06-02" version="1">MTRLVLGSASPGRLKVLRDAGIEPLVIASHVDEDVVIAALGPDAVPSDVVCVLAAAKAAQVATTLTGTQRIVAADCVVVACDSMLYIEGRLLGKPASIDEAREQWRSMAGRAGQLYTGHGVIRLQDNKTVYRAAETAITTVYFGTPSASDLEAYLASGESLRVAGGFTLDGLGGWFIDGVQGNPSNVIGLSLPLLRSLVQRCGLSVAALWAGNAGGPAHKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRP6</accession>
    <name>A0A7U8TRP6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="6">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="6">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tsaD</name>
        <name evidence="9" type="ORF">TBLG_03980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="6">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="6"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900052.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRP6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="344" mass="35091" checksum="032B3EB3862CB2A4" modified="2021-06-02" version="1">MTTVLGIETSCDETGVGIARLDPDGTVTLLADEVASSVDEHVRFGGVVPEIASRAHLEALGPAMRRALAAAGLKQPDIVAATIGPGLAGALLVGVAAAKAYSAAWGVPFYAVNHLGGHLAADVYEHGPLPECVALLVSGGHTHLLHVRSLGEPIIELGSTVDDAAGEAYDKVARLLGLGYPGGKALDDLARTGDRDAIVFPRGMSGPADDRYAFSFSGLKTAVARYVESHAADPGFRTADIAAGFQEAVADVLTMKAVRAATALGVSTLLIAGGVAANSRLRELATQRCGEAGRTLRIPSPRLCTDNGAMIAAFAAQLVAAGAPPSPLDVPSDPGLPVMQGQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRQ3</accession>
    <name>A0A7U8TRQ3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Esterase lipoprotein lpqC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417210.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRQ3"/>
    <dbReference type="GeneID" id="45427293"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="304" mass="31368" checksum="78C2C39E1FAEFC0E" modified="2021-06-02" version="1">MPWARMLSLIVLMVCLAGCGGDQLLARHASSVATFQFGGLTRSYRLHVPPAEPSGLVISLHGGGGTGAGQEALTDFDAVADAADLLVVYPDGYDKSWADGRGASPADRRHLDDVGFLVALAAKLVHDFDIAPGHVFATGMSNGGFMSNRLACDRADIFAAVAPVAGTLGVGVTCNPSRPVSVLEAHGTADPLVPFNGGAVRGRGGLSHSISVASLVDRWRAVDGCQGDPSAAELPDVGDGTMVHLFDSSSCAAGTEVISYQIDNGGHTWPGGRQYLPKAVIGATTRAFDGSQVIAQFFATHGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRQ8</accession>
    <name>A0A7U8TRQ8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417881.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRQ8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="214" mass="23733" checksum="9A32D9D3FAC17F8F" modified="2021-06-02" version="1">MTLNLSVDEVLTTTRSVRKRLDFDKPVPRDVLMECLELALQAPTGSNSQGWQWVFVEDAAKKKAIADVYLANARGYLSGPAPEYPDGDTRGERMGRVRDSATYLAEHMHRAPVLLIPCLKGREDESAVGGVSFWASLFPAVWSFCLALRSRGLGSCWTTLHLLDNGEHKVADVLGIPYDEYSQGGLLPIAYTQGIDFRPAKRLPAESVTHWNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRS5</accession>
    <name>A0A7U8TRS5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase amiD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417900.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRS5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="475" mass="50646" checksum="8A74C138EE3C6745" modified="2021-06-02" version="1">MTDADSAVPPRLDEDAISKLELTEVADLIRTRQLTSAEVTESTLRRIERLDPQLKSYAFVMPETALAAARAADADIARGHYEGVLHGVPIGVKDLCYTVDAPTAAGTTIFRDFRPAYDATVVARLRAAGAVIIGKLAMTEGAYLGYHPSLPTPVNPWDPTAWAGVSSSGCGVATAAGLCFGSIGSDTGGSIRFPTSMCGVTGIKPTWGRVSRHGVVELAASYDHVGPITRSAHDAAVLLSVIAGSDIHDPSCSAEPVPDYAADLALTRIPRVGVDWSQTTSFDEDTTAMLADVVKTLDDIGWPVIDVKLPALAPMVAAFGKMRAVETAIAHADTYPARADEYGPIMRAMIDAGHRLAAVEYQTLTERRLEFTRSLRRVFHDVDILLMPSAGIASPTLETMRGLGQDPELTARLAMPTAPFNVSGNPAICLPAGTTARGTPLGVQFIGREFDEHLLVRAGHAFQQVTGYHRRRPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRY0</accession>
    <name>A0A7U8TRY0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsD</name>
        <name evidence="10" type="ORF">TBLG_04111</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="6">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418354.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRY0"/>
    <dbReference type="GeneID" id="45427447"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="9">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="91"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD15217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="201" mass="23476" checksum="013594A411325FD5" modified="2021-06-02" version="1">MARYTGPVTRKSRRLRTDLVGGDQAFEKRPYPPGQHGRARIKESEYLLQLQEKQKARFTYGVMEKQFRRYYEEAVRQPGKTGEELLKILESRLDNVIYRAGLARTRRMARQLVSHGHFNVNGVHVNVPSYRVSQYDIVDVRDKSLNTVPFQIARETAGERPIPSWLQVVGERQRVLIHQLPERAQIDVPLTEQLIVEYYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRZ2</accession>
    <name>A0A7U8TRZ2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein yrbE4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="280" mass="29576" checksum="51EC530725ED50BC" modified="2021-06-02" version="1">MSYDVTIRFRRFFSRLQRPVDNFGEQALFYGETMRYVPNAITRYRKETVRLVAEMTLGAGALVMIGGTVGVAAFLTLASGGVIAVQGYSSLGDIGIEALIGFLSAFLNVRVVAPVIAGIALAATIGAGATAQLGAMRVSEEIDAVECMAVHSVSYLVSTRLIAGLVAIIPLYSLSVLAAFFAARFTTVFVNGQSAGLYDHYFNTFLIPSDLLWSFMQAIAMSIAVMLVHTYYGYNASGGSVGVGVAVGQAVRTSLIVVVVITLFISLAVYGASGNFNLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTF0</accession>
    <name>A0A7U8TTF0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, deoR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416005.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTF0"/>
    <dbReference type="GeneID" id="45427059"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="202" mass="21958" checksum="DD5CF31A5DBC97B9" modified="2021-06-02" version="1">MTAGSDRRPRDPAGRRQAIVEAAERVIARQGLGGLSHRRVAAEANVPVGSTTYYFNDLDALREAALAHAANASADLLAQWRSDLDKDRDLAATLARLTTVYLADQDRYRTLNELYMAAAHRPELQRLARLWPDGLLALLEPRIGRRAANAVTVFFDGATLHALITGTPLSTDELTDAIARLVADGPEQREVGQSAHAGRTPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTS8</accession>
    <name>A0A7U8TTS8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator pvdS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03866</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTS8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022486">
        <property type="entry name" value="PPK2_PA0141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03707">
        <property type="entry name" value="PPK2_P_aer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="5">
        <location>
            <begin position="33"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="295" mass="34124" checksum="BAE7A32AE71FE634" modified="2021-06-02" version="1">MDIPSVDVSTATNDGASSRAKGHRSAAPGRRKISDAVYQAELFRLQTEFVKLQEWARHSGARLVVIFEGRDGAGKGGAIKRITEYLNPRVARIAALPAPTDRERGQWYYQRYIAHLPAKGEIVLFDRSWYNRAGVEKVMGFCTPQEYVLFLRQTPIFEQMLIDDGILLRKYWFSVSDAEQLRRFKARRNDPVRQWKLSPMDLESVYRWEDYSRAKDEMMVHTDTPVSPWYVVESDIKKHARLNMMAHLLSTIDYADVEKPKVKLPPRPLVSGNYRRPPRELSTYVDDYVATLIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y255</accession>
    <name>A0A7U8Y255_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmC</name>
        <name evidence="6" type="ORF">TBLG_02853</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403594.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y255"/>
    <dbReference type="GeneID" id="45424674"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="77" mass="8859" checksum="F786EEB9FF265247" modified="2021-06-02" version="1">MAVGVSPGELRELTDEELAERLRESKEELFNLRFQMATGQLNNNRRLRTVRQEIARIYTVLRERELGLATGPDGKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2C0</accession>
    <name>A0A7U8Y2C0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="88" mass="10123" checksum="E15E7165C994160C" modified="2021-06-02" version="1">MCWGFSQRLIAAYAHPDRRRGKTSPTEAINGRLDALRRNALGLPELRALMRGDSRLSPHSRFHTEHPASDPPHRLNGRRTHHANRQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2E1</accession>
    <name>A0A7U8Y2E1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010427">
        <property type="entry name" value="DUF1023"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06259">
        <property type="entry name" value="Abhydrolase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="266" mass="28069" checksum="E1FA43081A6B61AD" modified="2021-06-02" version="1">MLQRELTRLQNGWLSRDGVWHTDTDKLADLRALRDTLAAHPGTSLILLDTASDPRKVLAAVGVGDVDNAERVGVTMGGLNTRVSSSVGDMVKEAGIQRAKAAELRERAGWPNYDAVASIAWLGYDAPDGLKDVMHDWSARDAAGPLNRFDKGLAATTNVSDQHITAFGHSYGSLVTSLALQQGAPVSDVVLYGSPGTELTHASQLGVEPGHAFYMIGVNDHVANTIPEFGAFGSAPQDVPGMTQLSVNTGLAPGPLLGDGQLHERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2G6</accession>
    <name>A0A7U8Y2G6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FGE-sulfatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403610.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2G6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGE-sulfatase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="299" mass="32744" checksum="BB06E071070AC02D" modified="2021-06-02" version="1">MLTELVDLPGGSFRMGSTRFYPEEAPIHTVTVRAFAVERHPVTNAQFAEFVSATGYVTVAEQPLDPGLYPGVDAADLCPGAMVFCPTAGPVDLRDWRQWWDWVPGACWRHPFGRDSDIADRAGHPVVQVAYPDAVAYARWAGRRLPTEAEWEYAARGGTTATYAWGDQEKPGGMLMANTWQGRFPYRNDGALGWVGTSPVGRFPANGFGLLDMIGNVWEWTTTEFYPHHRIDPPSTACCAPVKLATAADPTISQTLKGGSHLCAPEYCHRYRPAARSPQSQDTATTHIGFRCVADPVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2H9</accession>
    <name>A0A7U8Y2H9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405760.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2H9"/>
    <dbReference type="GeneID" id="45425061"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="106" mass="11544" checksum="9447236936812197" modified="2021-06-02" version="1">MPCVGYGDRREFVDAVAVEAICENLNTSGQPDPDLVIRTSGEQRLSGHRGPTGGVSRRRLLRALRDYSTPHASIPYVPPPYRSDGIHASRLAVESVFDALAGRVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2M9</accession>
    <name>A0A7U8Y2M9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Drugs-transport transmembrane ATP-binding protein ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03453</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406569.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2M9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="42"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="397"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="430"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="631" mass="68305" checksum="7B7A2D5E91AD06ED" modified="2021-06-02" version="1">MTAPPGARPRAASPPPNMRSRDFWGSAARLVKRLAPQRRLSIAVITLGIAGTTIGVIVPRILGHATDLLFNGVIGRGLPGGITKAQAVASARARGDNTFADLLSGMNVVPGQGVDFAAVERTLALALALYLAAALMIWAQARLLNLTVQKTMVRLRTDVEDKVHRLPLSYFDGQQRGELLSRVTNDIDNLQSSLSMTISQLVTSILTMVAVLAMMVSISGLLALITLLTVPLSLLVTRAITRRSQPLFVAHWTSTGRLNAHLEETYSGFTVVKTFGHQAAARERFHELNDDVYQAGFGAQFLSGLVQPATAFIGNLGYVAVAVAGGLQVATGQITLGSIQAFIQYIRQFNMPLSQLAGMYNALQSGVASAERVFDVLDEPEESPEPEPELPNLTGRVEFEHVNFAYLPGTPVIRDLSLVAEPGSTVAIVGPTGAGKTTLVNLLMRFYEIGSGRILIDGVDIASVSRQSLRSRIGMVLQDTWLYDGTIAENIAYGRPEATTDEIVEAARAAHVDRFVNTLPAGYQTRVSGDGGSISVGEKQLITIARAFLARPQLLILDEATSSVDTRTELLIQRAMRELRRDRTSFIIAHRLSTIRDADHILVVQTGQIVERGNHAELLARRGVYYQMTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2N0</accession>
    <name>A0A7U8Y2N0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_02828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="339" mass="37298" checksum="E82AAA0C1F8C2362" modified="2021-06-02" version="1">MAKAKFQRTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPDLNETKAFDQIDNAPEERQRGITINIAHVEYQTDKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKADAVDDEELLELVEMEVRELLAAQEFDEDAPVVRVSALKALEGDAKWVASVEELMNAVDESIPDPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVINVNEEVEIVGIRPSTTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGVKREDVERGQVVTKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQSTSAPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Q2</accession>
    <name>A0A7U8Y2Q2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03051</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5 8">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901040.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Q2"/>
    <dbReference type="GeneID" id="45424859"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004108">
        <property type="term" value="F:citrate (Si)-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06114">
        <property type="entry name" value="EcCS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024176">
        <property type="entry name" value="Citrate_synthase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010953">
        <property type="entry name" value="Citrate_synthase_typ-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001369">
        <property type="entry name" value="Citrate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01798">
        <property type="entry name" value="cit_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001369-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="431" mass="47978" checksum="FA818DFFCBC5D1B9" modified="2021-06-02" version="1">MADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFDVGFANTAAAKSSITYIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDLKRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMDNGQVELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNSLTLVENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQNCSTSTVRLVGSSRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRDSGDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDSLLGIAKELEEAALTDDYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWREMHDEGDSKIGRPRQIYTGYTERDYVTIDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Q4</accession>
    <name>A0A7U8Y2Q4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component system transcriptional regulator phoP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02903</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403867.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Q4"/>
    <dbReference type="GeneID" id="45424722"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="247" mass="27514" checksum="11DA6C43F4761061" modified="2021-06-02" version="1">MRKGVDLVTAGTPGENTTPEARVLVVDDEANIVELLSVSLKFQGFEVYTATNGAQALDRARETRPDAVILDVMMPGMDGFGVLRRLRADGIDAPALFLTARDSLQDKIAGLTLGGDDYVTKPFSLEEVVARLRVILRRAGKGNKEPRNVRLTFADIELDEETHEVWKAGQPVSLSPTEFTLLRYFVINAGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDTGEKRLLHTLRGVGYVLREPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Q7</accession>
    <name>A0A7U8Y2Q7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="6">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purD</name>
        <name evidence="9" type="ORF">TBLG_02918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="6"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898580.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Q7"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="107"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="422" mass="43509" checksum="1FB82706EBEB19A1" modified="2021-06-02" version="1">MRVLVIGSGAREHALLLALGKDPQVSGLIVAPGNAGTARIAEQHDVDITSAEAVVALAREVGADMVVIGPEVPLVLGVADAVRAAGIVCFGPGKDAARIEGSKAFAKDVMAAAGVRTANSEIVDSPAHLDAALDRFGPPAGDPAWVVKDDRLAAGKGVVVTADRDVARAHGAALLEAGHPVLLESYLDGPEVSLFCVVDRTVVVPLLPAQDFKRVGEDDTGLNTGGMGAYAPLPWLPDNIYREVVSRIVEPVAAELVRRGSSFCGLLYVGLAITARGPAVVEFNCRFGDPETQAVLALLESPLGQLLHAAATGKLADFGELRWRDGVAVTVVLAAENYPGRPRVGDVVVGSEAEGVLHAGTTRRDDGAIVSSGGRVLSVVGTGADLSAARAHAYEILSSIRLPGGHFRSDIGLRAAEGKISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2W3</accession>
    <name>A0A7U8Y2W3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="1">
        <location>
            <begin position="2"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="287" mass="31995" checksum="231CA1F807D54259" modified="2021-06-02" version="1">MCRLFGLHSGTDAVTATFWLLNASDSLAEQSRRNPDGTGLGVFDEHHQPRLHKQPIAAWQDADFATEAHELTGTTFVAHVRYATTGSLDIRNTHPFLQDGRIFAHNGVVEGLDVLDERLREVGADDLVLGQTDSERVFALITASIRARDGNESAGLIDALRWLAANVPIYAVNVLLSTATDVWALRYPESHELYILDRRGDGAPEFHLRSKRIRAHSTHLRERSSVVFATEPMDDNPRWRLLDAGELVHVDAALRVNRSLVLPDPPRHPILREDLSEPVLHAQHTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Y7</accession>
    <name>A0A7U8Y2Y7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family. ESAT-6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Y7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009416">
        <property type="entry name" value="ESAT-6-like_Myco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037656">
        <property type="entry name" value="DUF1066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="94" mass="9818" checksum="8F9701831E93F657" modified="2021-06-02" version="1">MTINYQFGDVDAHGAMIRALAGSLEAEHQAIISDVLTASDFWGGAGSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y312</accession>
    <name>A0A7U8Y312_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Multifunctional 2-oxoglutarate metabolism enzyme</fullName>
            <ecNumber evidence="10">1.2.4.2</ecNumber>
            <ecNumber evidence="12">2.2.1.5</ecNumber>
            <ecNumber evidence="11">2.3.1.61</ecNumber>
            <ecNumber evidence="9">4.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="26">2-hydroxy-3-oxoadipate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">2-oxoglutarate carboxy-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">2-oxoglutarate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Alpha-ketoglutarate decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Alpha-ketoglutarate-glyoxylate carboligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="35" type="ORF">TBLG_03426</name>
    </gene>
    <organism evidence="35 36">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="35 36" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35 36">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="31">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10483"/>
            <dbReference type="Rhea" id="RHEA-COMP:10484"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) = CO2 + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:10524"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="4.1.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO2</text>
            <dbReference type="Rhea" id="RHEA:14341"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57712"/>
            <dbReference type="EC" id="2.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from 2-oxoglutarate (transferase route): step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="10"/>
    <dbReference type="EC" id="2.2.1.5" evidence="12"/>
    <dbReference type="EC" id="2.3.1.61" evidence="11"/>
    <dbReference type="EC" id="4.1.1.71" evidence="9"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00997"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="25" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="15" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="22 32" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="18" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="23" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="24" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="21" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="16" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transket_pyr" evidence="34">
        <location>
            <begin position="863"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="32">
        <location>
            <begin position="773"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00012226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00013148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00020204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00029773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00030696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00032625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00032880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00033243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00033664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="EFD12842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1214" mass="134031" checksum="87A597C913AAB43A" modified="2021-06-02" version="1">MYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLVAERAAAAAPQAPPKPADTAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSASLEVPTATSVRAVPAKLLIDNRIVINNQLKRTRGGKISFTHLLGYALVQAVKKFPNMNRHYTEVDGKPTAVTPAHTNLGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRRARDGKLTTEDFAGVTISLTNPGTIGTVHSVPRLMPGQGAIIGVGAMEYPAEFQGASEERIAELGIGKLITLTSTYDHRIIQGAESGDFLRTIHELLLSDGFWDEVFRELSIPYLPVRWSTDNPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRVFKVDGFAGAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPTVAQQKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMPHRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVSLTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAETLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEACVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYMYDVVDTKRGARKSYTEALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHGVQPSESVESDQMIPAGLATAVDKSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGKIDWAFGELLALGSLVAEGKLVRLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLSEYAAVGFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEGQGPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDSIQRPLIVFTPKSMLRHKAAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLYYELAARKAKDNRNDLAIVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPRFGLELPELLPDKLAGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y350</accession>
    <name>A0A7U8Y350_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar-transport membrane protein ABC transporter sugA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03413</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406295.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y350"/>
    <dbReference type="GeneID" id="45425206"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="85"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="307" mass="33051" checksum="8B88E852E40F622D" modified="2021-06-02" version="1">MTSVEQRTATAVFSRTGSRMAERRLAFMLVAPAAMLMVAVTAYPIGYALWLSLQRNNLATPNDTAFIGLGNYHTILIDRYWWTALAVTLAITAVSVTIEFVLGLALALVMHRTLIGKGLVRTAVLIPYGIVTVVASYSWYYAWTPGTGYLANLLPYDSAPLTQQIPSLGIVVIAEVWKTTPFMSLLLLAGLALVPEDLLRAAQVDGASAWRRLTKVILPMIKPAIVVALLFRTLDAFRIFDNIYVLTGGSNNTGSVSILGYDNLFKGFNVGLGSAISVLIFGCVAVIAFIFIKLFGAAAPGGEPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y387</accession>
    <name>A0A7U8Y387_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mycobactin import ATP-binding/permease protein IrtA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">TBLG_03533</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a heterodimer with IrtB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ABC transporter superfamily. Siderophore-Fe(3+) uptake transporter (SIUT) (TC 3.A.1.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013113">
        <property type="entry name" value="FAD-bd_9_SIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007037">
        <property type="entry name" value="SIP_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08021">
        <property type="entry name" value="FAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04954">
        <property type="entry name" value="SIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="401"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="17">
        <location>
            <begin position="294"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="16">
        <location>
            <begin position="610"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="643"/>
            <end position="650"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EFD12949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="859" mass="93014" checksum="37D09BC16459C9BD" modified="2021-06-02" version="1">MARGLQGVMLRSFGARDHTATVIETISIAPHFVRVRMVSPTLFQDAEAEPAAWLRFWFPDPNGSNTEFQRAYTISEADPAAGRFAVDVVLHDPAGPASSWARTVKPGATIAVMSLMGSSRFDVPEEQPAGYLLIGDSASIPGMNGIIETVPNDVPIEMYLEQHDDNDTLIPLAKHPRLRVRWVMRRDEKSLAEAIENRDWSDWYAWATPEAAALKCVRVRLRDEFGFPKSEIHAQAYWNAGRAMGTHRATEPAATEPEVGAAPQPESAVPAPARGSWRAQAASRLLAPLKLPLVLSGVLAALVTLAQLAPFVLLVELSRLLFSGAGAHRLFTVGFAAVGLLGTGALLAAALTLWLHVIDARFARALRLRLLSKLSRLPLGWFTSRGSGSIKKLVTDDTLALHYLVTHAVPDAVAAVVAPVGVLVYLFVVDWRVALVLFGPVLVYLTITSSLTIQSGPRIVQAQRWAEKMNGEAGSYLEGQPVIRVFGAASSSFRRRLDEYIGFLVAWQRPLAGKKTLMDLATRPATFLWLIAATGTLLVATHRMDPVNLLPFMFLGTTFGARLLGIAYGLGGLRTGLLAARHLQVTLDETELAVREHPREPLDGEAPATVVFDHVTFGYRPGVPVIQDVSLTLRPGTVTALVGPSGSGKSTLATLLARFHDVERGAIRVGGQDIRSLAADELYTRVGFVLQEAQLVHGTAAENIALAVPDAPAEQVQVAAREAQIHDRVLRLPDGYDTVLGANSGLSGGERQRLTIARAILGDTPVLILDEATAFADPESEYLVQQALNRLTRDRTVLVIAHRLHTITRADQIVVLDHGRIVERGTHEELLAAGGRYCRLWDTGQGSRVAVAAAQDGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y458</accession>
    <name>A0A7U8Y458_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="215" mass="22892" checksum="0AC27CD04DD5BD4A" modified="2021-06-02" version="1">MALAKLAQSADRIAARQRMQRSLAQLVATCELPAPTGTAPIERRISESFAASRSTRRSPIAQSMTRPSPPRPGSPTLPVDGEDPFAEAVLTASVSCRLYPTDTGGTPADRCTPATGGEFPTSALIASRGAAYPATQPNGPSIRTILRALAIHRRPSANSKLGAVTTEFDTSAPRILDQLHASDVIRLDASARCILSPQHRIRIVFRSPMVPRFSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y480</accession>
    <name>A0A7U8Y480_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="241" mass="24872" checksum="F56B90ECA5051126" modified="2021-06-02" version="1">MNLGQTLVGIATWPARAGLAAADTGLNMAGAAVDMAKQALGDAGGASGSTSMANMLGIDDTIARANRLARLLDDDMPLGRAIAPNGPMDRMLRPGGVVDLLTQPGGLLDRLTAEGGAMQRALQPGGLADQLLAEDGLIERVLSEDGLADRLLAEGGLIDKTTAKDGPLEQLADVADTLARLTPGMEALEPAIATLQDAVIALTMVVNPLSSIAERIPLPGRRPARRSSSRSVRSQRVVDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4C5</accession>
    <name>A0A7U8Y4C5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="66"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="383" mass="42744" checksum="9BB4298F30670542" modified="2021-06-02" version="1">MTEYVKFGQIIESSPGAFEESLSRDSAACSTGCRPQKPMSAQALREEIGSELARLSFNRRKRLSSPGSIDQVHYLTLRSGEEVGSDPAAGHPPPRAADLQILKRFAQTVELAKLGRRLSAQDVVADFADNLAEELDFRLEAQSMEAWVSHLHASPLGKNIRVPQVHWDFTTERVLTMERVHGIRIDNAAAIRKAGFDGVELVKALLFSVFEGGLRHGLFHGDLHAGNLYVDEAGRIVFFDFGIMGRIDPRTRWLLRELVYALLVKKDHAAAGKIVVLMGAVGTMKPETQAAKDLERFATPLTMQSLGDMSYADIGRQLSALADAYDVKLPRELVLIGKQFLYVERYMKLLAPRWQMMSDPQLTGYFANFMVEVSREHQSDIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4H2</accession>
    <name>A0A7U8Y4H2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Deoxyribonuclease tatD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4H2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="264" mass="29096" checksum="2FF3E92616456C59" modified="2021-06-02" version="1">MVDAHTHLDACGARDADTVRSLVERAAAAGVTAVVTVADDLESARWVTRAAEWDRRVYAAVALHPTRADALTDAARAELERLVAHPRVVAVGETGIDMYWPGRLDGCAEPHVQREAFAWHIDLAKRTGKPLMIHNRQADRDVLDVLRAEGAPDTVILHCFSSDAAMARTCVDAGWLLSLSGTVSFRNARELREAVPLMPVEQLLVETDAPYLTPHPHRGLANEPYCLPYTVRALAELVNRRPEEVALITTSNARRAYGLGWMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4J7</accession>
    <name>A0A7U8Y4J7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_02994</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404382.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4J7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="430" mass="43855" checksum="B904FA823AD2F67F" modified="2021-06-02" version="1">MRYTGPERCSGDGQVRAAGDRYSTVIWLLGGNLLVRSAGFGYPFLAYHVAGRGHGAGAVGAVVAAYGLGWAVGQLLCGWLVDRVGARVTLVSTMLVAAAVLVLMAGLHTVPGLLVGAMIAGLVCDAPRPVLGAVIAELVADPQRRAQLDGWRYGWVLNIGAAITGGVGGVVAGWLDTPVLYWINGIGCAIFAGLAGRCIPADVCRRTESGLRACTAMSKVGYRQALSDKRLVLLAVSGLATLTTLMGFFAAVPMLMSASGLGVGAYGWVQLINALAVVAVTPLLTPWLSKQLALGPRPDILAGAGVWVTLCMAAAGLARTTVGFSVAAAACSPGEIAWFVVAAGIVHRIAPPAHGGRYHGIWSMAVAASSVAAPILAAFNLANGGRLVLAATTVTVGFFGAALCLPLARVLAAASCGPLSSKEPSRDSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4Q0</accession>
    <name>A0A7U8Y4Q0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="358" mass="39518" checksum="3E383720F8B9F830" modified="2021-06-02" version="1">MPSIPQSLLWISLVVLWLFVLVPMLISKRDAVRRTSDVALATRVLNGGAGARLLKRGGPAAGHRWGYLPPEGQGDDPDWKPEEDWRDDPVEDGFADVEHDIDEDQEADDARRRGAVVMKVAAPQTAGADEPDYLDVDVVEEDSEALPVGAGAAVGESADEADAEAADGVAGHADPEADPVEYEYEYEYVEDTCGLELEEDDQEAPPTVASGTSRRRRFDTKTAAAVSARKYTFRKRALIVMAVILVGSAAAAFELTPVAWWICGSATGVTVLYLAYLRRQTRIEEKVRRRRMQRIARARLGVQNTRDREYDVVPSRLRRPGAVVLEIDDEDPIFTHLESAAPIRNYGWPRDLPRAVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4S9</accession>
    <name>A0A7U8Y4S9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03502</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="276"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="360"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="540" mass="59207" checksum="F0B61BC0C40E6A11" modified="2021-06-02" version="1">MSAKKSTAQRLGRVLETVTRQSGRLPETPAYGSWLLGRVSESQRRRRVRIQVMLTALVVTANLLGIGVALLLVTIAIPEPSIVRDTPRWLTFGVVPGYVLLALALGSYALTRQTVQALRWAIEGRKPTREEERRTFLAPWRVAVGHLMFWGVGTALLTTLYGLINNAFIIDRCSQQRGGVLVATATYLHTEFALRPFAAQALEAGPPPRRLAPGILGRTMVVWLLGSGVPVVGIALMAMFEMVLLNLTRMQFATGVLIISMVTLVFGFILMWILAWLTATPVRVVRAALRRVERGELRTNLVVFDGTELGELQRGFNAMVAGLRERERVRDLFGRHVGREVAAAAERERSKLGGEERHVAVVFIDIVGSTQLVTSRPPADVVKLLNKFFAIVVDEVDRHHGLVNKFEGDASLTIFGAPNRLPCPEDKALAAARAIADRLVNEMPECQAGIGVAAGQVIAGNVGARERFEYTVIGEPVNEAARLCELAKSRPGKLLASAQAVDAASEEERARWSLGRHVKLRGHDQPVRLAKPVGLTKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4U7</accession>
    <name>A0A7U8Y4U7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TfuA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900327.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4U7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012924">
        <property type="entry name" value="TfuA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016845">
        <property type="entry name" value="UCP026633_TfuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07812">
        <property type="entry name" value="TfuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026633">
        <property type="entry name" value="UCP026633_TfuA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TfuA" evidence="1">
        <location>
            <begin position="53"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="497" mass="54517" checksum="7DDEC524A1F2474A" modified="2021-06-02" version="1">MTACGRIVVTAGPTISAADIRSVVPDAEVAPPIAFGQALSYDLRSGDTLLIVDGLFFQQPSVRHKELLTLMADGVRVVGSSSMGALRAAELHPFGMEGYGWVFESYRDGVLEADDEVGVVHGDADDGYPVFVDALVNMRHTLARAVATGVVCSELAERIIETARATPFTMRTWARLLSEVGAPDQRGLAAQLRSLRVDVKHADALLALRQLGQRPRVEPLRPGPPPTVWSRRWRQRWAPPTSVAASADHGESFVDVTDLEVLSFLSVSSVDYWAYRPALQQVAAWYWTLKHPEQSGSVGERAARAVAEVASEGYGRALEFIAYRYALATGIIDETGFPEAVAAHWLTTEERHGLGNDPISISARVITRTLFVVRLLPAIDHFLDLLRKDSRLPRWRAMAAHALCKRDDLARQKPHLNLGRPDPTQLKRLFGARWGTQVNRIELARRGLMTEDAFYAAATPFAVAAVDDQLPRIEVGTLGPAPLSADVPERHFDFGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4U9</accession>
    <name>A0A7U8Y4U9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03324</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025161">
        <property type="entry name" value="Put_IS4/IS5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13340">
        <property type="entry name" value="DUF4096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="135" mass="15189" checksum="DE6A5A397E471DA2" modified="2021-06-02" version="1">MTRVGVISDEFWAVVEPLMPSHEGKPGRRFSDHRLILEGIAWRFRTGSPWRDLPAEFGPWQTVWKRHHRWSLDGTCDEVFAHVAAVFGVDAEVAEDIEKLLSVDSTNVRAHQHSAGACSDTLATGGTVELQEIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4V7</accession>
    <name>A0A7U8Y4V7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407295.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4V7"/>
    <dbReference type="GeneID" id="45425382"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="160" mass="17521" checksum="231F89F7000E318A" modified="2021-06-02" version="1">MMPTEYPATAEESVDVITDALLTASRLLVAISAHSIAQVDENITIPQFRTLVILSNHGPINLATLATLLGVQPSATGRMVDRLVGAELIDRLPHPTSRRELLAALTKRGRDVVRQVTEHRRTEIARIVEQMAPAERHGLVRALTAFTEAGGEPDARYEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7C4</accession>
    <name>A0A7U8Y7C4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="327" mass="36008" checksum="87836EBD1A6D3714" modified="2021-06-02" version="1">MTRSSNIPADATPNPHATAEQVAAARHDSKLAQVLYHDWEAENYDEKWSISYDQRCVDYARGRFDAIVPDEVIAQLPYDRALELGCGTGFFLLNLIQAGVARRGSVTDLSPGMVKVATRNGQALGLDIDGRVADAEGIPYDDDAFDLVVGHAVLHHVPDVELSLREVVRVLKPGGRFVFAGEPTTVGDGYARTLSTLTWRVVTNATKLPGLRGWRRPQGELDESSRAAALEALVDLHTFTPQDLQRIAHNAGAVEVQTATEEFTAAMLGWPLRTFECTVPPGQLGWGWARFAFTSWKTLGWVDANVWRHVVPKGWFYNVMITGVKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7S7</accession>
    <name>A0A7U8Y7S7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein mce4A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04149</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418979.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7S7"/>
    <dbReference type="GeneID" id="45427485"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="41"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="122"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="400" mass="42418" checksum="31B6B34D820D9F00" modified="2021-06-02" version="1">MSGGGSRRTSVRVAAALLAGLMVGSAVLTYLSYTAAFTSTDTVTVSSPRAGLVMEKGAKVKYRGIQVGKVTDISYSGNQARLKLAIDSGEMGFIPSNATVRIAGNTIFGAKSVEFIPPKTPSPKPLSPNAHVAASQVQLEVNTLFQSLIDLLHKIDPLETNATLSALSEGLRGHGDDLGALLSGLNTLTRQANPKLPALQEDFRKAAVVANVYADAAGDLNTVFDNLPTINKTIVDQKDNLNDTLLATIGLSNNAYETLAPAEQNFIDAINRLRAPLKVTSDYSPVFGCLFKGIARGVKEFAPLIGVRKAGLFTSSSFVLGAPSYTYPESLPIVNASGGPNCRGLPDIPTKQTGGSFYRAPFLVTDNALIPYQPFTELQVDAPSTLQFLFNGAFAERDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7X5</accession>
    <name>A0A7U8Y7X5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416624.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7X5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="495" mass="52082" checksum="0440961A0F5FCBA4" modified="2021-06-02" version="1">MAMSAKASDDIAWLPATAQLAVLAAKKVSSAELVELYLSRIDTYNASLNAIVTVDPDAARRVAKRSDAARARGDELGPLHGLPITVKDSYETAGMRTTCGRRDLADYVPTQDAEAVARLRRAGAIIMGKTNMPTGNQDVQASNPVFGRTNNPWDAARTSGGSAGGGAAATAAGLTSFDYGSEIGGSTRIPAHYCGLYGHKSTWRSVPLVGHIPSAPGNPGRWGQADMACAGVQVRGARDIIPALEATVGPMRADGGFSYALAPPRAGALKDFRVAVWAEDPHCPIDADVRRAMDDAVAALRAAGAHVVEQPATIPVDMAVSHNIFQSLVFGAFAVDRSTLSPASAAALGLRAVRHPRGEAANALGATLQSHRAWLFADAARHEMRDRWAGFFNEFDVLLLPVTPTPAPLHHNKDHDRLGRTIDVDGVSRSYWDQLKWNALANIAGTPATTMPITTTATGLPIGIQAMGPAGGDRTTVEFAALLTEVLGGFRVPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Z7</accession>
    <name>A0A7U8Y7Z7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03736</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="399"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="415" mass="45681" checksum="23FC2D6B17AC1074" modified="2021-06-02" version="1">MTSSHLIDTEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALCGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIGSNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRARAALTSTEEPAKQQTTNTPALTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y836</accession>
    <name>A0A7U8Y836_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y836"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="99" mass="11010" checksum="76AAE1F535198DD5" modified="2021-06-02" version="1">MRATVGLVEAIGIRELRQHASRYLARVEAGEELGVTNKGRLVARLIPVQAAERSREALIESGVLIPARRPQNLLDVTAEPARGRKRTLSDVLNEMRDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y861</accession>
    <name>A0A7U8Y861_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="8">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_04064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8 11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8 11">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="8"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417452.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y861"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="PTHR11822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 12" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Iso_dh" evidence="13">
        <location>
            <begin position="12"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="97"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="78"/>
            <end position="80"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="313"/>
            <end position="318"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="9">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD15170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="409" mass="45514" checksum="FDBC1989DF42383A" modified="2021-06-02" version="1">MSNAPKIKVSGPVVELDGDEMTRVIWKLIKDMLILPYLDIRLDYYDLGIEHRDATDDQVTIDAAYAIKKHGVGVKCATITPDEARVEEFNLKKMWLSPNGTIRNILGGTIFREPIVISNVPRLVPGWTKPIVIGRHAFGDQYRATNFKVDQPGTVTLTFTPADGSAPIVHEMVSIPEDGGVVLGMYNFKESIRDFARASFSYGLNAKWPVYLSTKNTILKAYDGMFKDEFERVYEEEFKAQFEAAGLTYEHRLIDDMVAACLKWEGGYVWACKNYDGDVQSDTVAQGYGSLGLMTSVLMTADGKTVEAEAAHGTVTRHYRQYQAGKPTSTNPIASIFAWTRGLQHRGKLDGTPEVIDFAHKLESVVIATVESGKMTKDLAILIGPEQDWLNSEEFLDAIADNLEKELAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y891</accession>
    <name>A0A7U8Y891_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_04154</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418997.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y891"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="234"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="400" mass="43785" checksum="2B25B8A76861F271" modified="2021-06-02" version="1">MRISYTPQQEELRRELRSYFATLMTPERREALSSVQGEYGVGNVYRETIAQMGRDGWLALGWPKEYGGQGRSAMDQLIFTDEAAIAGAPVPFLTINSVAPTIMAYGTDEQKRFFLPRIAAGDLHFSIGYSEPGAGTDLANLRTTAVRDGDDYVVNGQKMWTSLIQYADYVWLAVRTNPESSGAKKHRGISVLIVPTTAEGFSWTPVHTMAGPDTSATYYSDVRVPVANRVGEENAGWKLVTNQLNHERVALVSPAPIFGCLREVREWAQNTKDAGGTRLIDSEWVQLNLARVHAKAEVLKLINWELASSQSGPKDAGPSPADASAAKVFGTELATEAYRLLMEVLGTAATLRQNSPGALLRGRVERMHRACLILTFGGGTNEVQRDIIGMVALGLPRANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9V4</accession>
    <name>A0A7U8Y9V4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransf_11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415922.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y9V4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="2">
        <location>
            <begin position="66"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="274" mass="29984" checksum="E50314FC7518FD0A" modified="2021-06-02" version="1">MCAFVPHVPRHSRGDNPPSASTASPAVLTLTGERTIPDLDIENYWFRRHQVVYQRLAPRCTARDVLEAGCGEGYGADLIACVARQVIAVDYDETAVAHVRSRYPRVEVMQANLAELPLPDASVDVVVNFQVIEHLWDQARFVRECARVLRGSGLLMVSTPNRITFSPGRDTPINPFHTRELNADELTSLLIDAGFVDVAMCGLFHGPRLRDMDARHGGSIIDAQIMRAVAGAPWPPELAADVAAVTTADFEMVAAGHDRDIDDSLDLIAIAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9Z3</accession>
    <name>A0A7U8Y9Z3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoD</name>
        <name evidence="8" type="ORF">TBLG_03769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y9Z3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="7">
        <location>
            <begin position="155"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="440" mass="48164" checksum="75959DE0D084A638" modified="2021-06-02" version="1">MTAIADSAGGAGETVLVAGGQDWQQVVDAARSADPGERIVVNMGPQHPSTHGVLRLILEIEGETVVEARCGIGYLHTGIEKNLEYRYWTQGVTFVTRMDYLSPFFNETAYCLGVEKLLGITDEIPERVNVIRVLMMELNRISSHLVALATGGMELGAMTPMFVGFRAREIVLTLFEKITGLRMNSAYIRPGGVAQDLPPNAATEIAEALKQLRQPLREMGELLNENAIWKARTQGVGYLDLTGCMALGITGPILRSTGLPHDLRKSEPYCGYQHYEFDVITDDSCDAYGRYMIRVKEMWESMKIVEQCLDKLRPGPTMISDRKLAWPADLQVGPDGLGNSPKHIAKIMGSSMEALIHHFKLVTEGIRVPAGQVYVAVESPRGELGVHMVSDGGTRPYRVHYRDPSFTNLQSVAAMCEGGMVADLIAAVASIDPVMGGVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA05</accession>
    <name>A0A7U8YA05_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416362.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA05"/>
    <dbReference type="GeneID" id="45427117"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="332" mass="35978" checksum="8C28FF93130D131A" modified="2021-06-02" version="1">MNTHFPDAETVRTVLTLAVRAPSIHNTQPWRWRVCPTSLELFSRPDMQLRSTDPDGRELILSCGVALHHCVVALASLGWQAKVNRFPDPKDRCHLATIGVQPLVPDQADVALAAAIPRRRTDRRAYSCWPVPGGDIALMAARAARGGVMLRQVSALDRMKAIVAQAVLDHVTDEEYLRELTIWSGRYGSVAGVPARNEPPSDPSAPIPGRLFAGPGLSQPSDVLPADDGAAILALGTETDDRLARLRAGEAASIVLLTATAMGLACCPITEPLEIAKTRDAVRAEVFGAGGYPQMLLRVGWAPINADPLPPTPRRELSQVVEWPEELLRQRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA81</accession>
    <name>A0A7U8YA81_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphomannomutase pmmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03947</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA81"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="207"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="304"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="486"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD15049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="534" mass="56166" checksum="A5AD2A5053D76C63" modified="2021-06-02" version="1">MTPENWIAHDPDPQTAAELAACGPDELKARFSRPLAFGTAGLRGHLRGGPDAMNLAVVLRATWAVARVLTDRGLAGSPVIVGRDARHGSPAFAAAAAEVLAAAGFSVLLLPDPAPTPVVAFAVRHTGAAAGIQITASHNPATDNGYKVYVDGGLQLLAPTDRQIEAAMATAPPADQIARKTVNPSENRASDLIDRYIQRAAGVRRCAGSVRVALTPLHGVGGAMAVETLRRAGFTEVHTVATQFAPNPDFPTVTLPNPEEPGATDALLTLATDVDADVAIALDPDADRCAVGIPTVSGWRMLSGDETGWLLGDYILSQTDDRASPPETRVVASTVVSSRMLAAIAAHHAAVHVETLTGFKWLARADANLPGTLVYAYEEAIGHCVDPTAVRDKDGISAAVLVCDLVAALKGQGRSVTDALDELARCYGVHEVAALSRPVGGAVETTDLMRRLREDPPRRLAGFPATVTDIGDTLILTGGDDNMLVRVAVRPSGTEPKLKCYLEIRCAVTGDLPAARQLVRARIDELSASVRRWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF66</accession>
    <name>A0A7U8TF66_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein yrbE2A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403095.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF66"/>
    <dbReference type="GeneID" id="45424555"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="265" mass="27327" checksum="1632EE79C5D0CD44" modified="2021-06-02" version="1">MTTHAVIITYLRDQTQPAVDAIGGFYRTCVLTGKALVRRPFHWREAIEQGWFITSVSLLPTLAVSIPLTVLIIFTLNILLAEFGAADISGAGAALGAVTQLGPLTTVLVIAGAGATAICADLGARTIREEIDAMEVLGIDPIHRLVVPRVVAATIVAALLNGAVITIGLVGGFVFSVFIQHVSAGAYVGTLTLVTGLPEVIISVVKSATFGLIAGLVGCYRGLTTKGGPKGVGTAVNETLVLCVIALFATNVVLTTIGVRFGTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF82</accession>
    <name>A0A7U8TF82_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_02741</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403187.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF82"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="133" mass="14533" checksum="94BFC7469D7D706F" modified="2021-06-02" version="1">MIVDTSAIIAILRDEDDAAAYADALANADVRRLSAASYLECGIVLDSQRDPVISRALDELIEEAEFVVEPVTERQARLARAAYADFGRGSGHPAGLNFGDCLSYALAIDRREPLLWKGNDFGHTGVQRALDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF90</accession>
    <name>A0A7U8TF90_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403232.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="140"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="315" mass="33420" checksum="F167E52CA2C83D25" modified="2021-06-02" version="1">MSFCVYCGAELADPTRCGACGAYKIGSTWHRTTTPTVGAATTATGWRPDPTGRHEGRYFVAGQPTDLVREGDAEAVDPLGQQQLDQSGAVGVSPSAVSGWVRSGHRRLWWALAGVVAFLGLVGAGVVGTLFLNRDRESIDDKYLAALRRSGLTGEFNSDANAIARGKQVCRQLQDGGEQQGMPVDQVAVQYYCPQFSDGFHILETITVTGSFTLKDESPNVYAPAITVSGSGCSGSAGYADIDRGTQVTVKNGQGDILATAFLQAGQGGRFLCTFPFSFEITEGEDRYVVSVSRRGEMSYSFADLKANGLSLVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF95</accession>
    <name>A0A7U8TF95_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_02762</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403246.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF95"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="135" mass="14408" checksum="E0763876C27DF722" modified="2021-06-02" version="1">MSTTPAAGVLDTSVFIATESGRQLDEALIPDRVATTVVTLAELRVGVLAAATTDIRAQRLATLESVADMETLPVDDDAARMWARLRIHLAESGRRVRINDLWIAAVAASRALPVITQDDDFAALDGAASVEIIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFB2</accession>
    <name>A0A7U8TFB2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonucleotide-transport ATP-binding protein ABC transporter mkl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="28"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="60"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="359" mass="39422" checksum="8C7C0B6C2B72AFC7" modified="2021-06-02" version="1">MRYSDSYHTTGRWQPRASTEGFPMGVSIEVNGLTKSFGSSRIWEDVTLTIPAGEVSVLLGPSGTGKSVFLKSLIGLLRPERGSIIIDGTDIIECSAKELYEIRTLFGVLFQDGALFGSMNLYDNTAFPLREHTKKKESEIRDIVMEKLALVGLGGDEKKFPGEISGGMRKRAGLARVLVLDPQIILCDEPDSGLDPVRTAYLSQLIMDINAQIDATILIVTHNINIARTVPDNMGMLFRKHLVMFGPREVLLTSDEPVVRQFLNGRRIGPIGMSEEKDEATMAEEQALLDAGHHAGGVEEIEGVPPQISATPGMPERKAVARRQARVREMLHTLPKKAQAAILDDLEGTHKYAVHEIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFB6</accession>
    <name>A0A7U8TFB6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="122" mass="14065" checksum="89E230FA8F0EA1B4" modified="2021-06-02" version="1">MFLPNTRAYRRYNRSVWAVRGSTRPQWQPPPKFQHAKCMSMRLAHRLQILLDDECHRRITAVARERGVPVATVVREAIDRGLVSPAGRRKSAGRRLLDAADMSVPEPRELKQELEALRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFE8</accession>
    <name>A0A7U8TFE8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 9">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplW</name>
        <name evidence="10" type="ORF">TBLG_02847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403581.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFE8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 9" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="100" mass="10958" checksum="45316B7DDC064AB3" modified="2021-06-02" version="1">MATLADPRDIILAPVISEKSYGLLDDNVYTFLVRPDSNKTQIKIAVEKIFAVKVASVNTANRQGKRKRTRTGYGKRKSTKRAIVTLAPGSRPIDLFGAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFF1</accession>
    <name>A0A7U8TFF1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-lactate dehydrogenase lldD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_02837</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02809">
        <property type="entry name" value="alpha_hydroxyacid_oxid_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023989">
        <property type="entry name" value="MftD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03966">
        <property type="entry name" value="actino_HemFlav"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="309"/>
            <end position="313"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="332"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="396" mass="42177" checksum="9E9410A80A5C268C" modified="2021-06-02" version="1">MAEAWFETVAIAQQRAKRRLPKSVYSSLIAASEKGITVADNVAAFSELGFAPHVIGATDKRDLSTTVMGQEVSLPVIISPTGVQAVDPGGEVAVARAAAARGTVMGLSSFASKPIEEVIAANLKTFFQVYWQGGRDALAERVERARQAGAVGLVVTTDWTFSHGRDWGSPKIPEEMNLKTILRLSPEAITRPRWLWKFAKTLRPPDLRVPNQGRRGEPGPPFFAAYGEWMATPPPTWEDIGWLRELWGGPFMLKGVMRVDDAKRAVDAGVSAISVSNHGGNNLDGTPASIRALPAVSAAVGDQVEVLLDGGIRRGSDVVKAVALGARAVMIGRAYLWGLAANGQAGVENVLDILRGGIDSALMGLGHASVHDLSPADILVPTGFIRDLGVPSRRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFG7</accession>
    <name>A0A7U8TFG7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="301" mass="32263" checksum="EE444944D6D2B739" modified="2021-06-02" version="1">MPRAHDDNWDLASSVGATATMVAAGRALATKDPRGLINDPFAEPLVRAVGLDFFTKLIDGELDIATTGNLSPGRAQAMIDGIAVRTKYFDDYFRTATDGGVRQVVILAAGLDARAYRLPWPAGTVVYEIDQPQVIDFKTTTLAGIGAKPTAIRRTVYIDLRADWPAALQAAGLDSTAPTAWLAEGMLIYLPPDPRTGCSTTAPNSVLRAARSLPNLSRALWISTQAGYEKWRIRFASTAWTSTWRRWCILANAATSSTTCAPRAGTLRAQCGPTYSGAMVCPFPPHTTTIRSAKSSSSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFI3</accession>
    <name>A0A7U8TFI3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transmembrane transporter mmpL5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_02818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004707">
        <property type="entry name" value="MmpL_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00833">
        <property type="entry name" value="actII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="801"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="832"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="874"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="63"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="MMPL" evidence="8">
        <location>
            <begin position="618"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="964" mass="104783" checksum="B52341E1D25B6E04" modified="2021-06-02" version="1">MIVQRTAAPTGSVPPDRHAARPFIPRMIRTFAVPIILGWLVTIAVLNVTVPQLETVGQIQAVSMSPDAAPSMISMKHIGKVFEEGDSDSAAMIVLEGQRPLGDAAHAFYDQMIGRLQADTTHVQSLQDFWGDPLTATGAQSSDGKAAYVQVKLAGNQGESLANESVEAVKTIVERLAPPPGVKVYVTGSAALVADQQQAGDRSLQVIEAVTFTVIIVMLLLVYRSIITSAIMLTMVVLGLLATRGGVAFLGFHRIIGLSTFATNLLVVLAIAAATDYAIFLIGRYQEARGLGQDRESAYYTMFGGTAHVVLGSGLTIAGATFCLSFTRLPYFQTLGVPLAIGMVIVVAAALTLGPAIIAVTSRFGKLLEPKRMARVRGWRKVGAAIVRWPGPILVGAVALALVGLLTLPGYRTNYNDRNYLPADLPANEGYAAAERHFSQARMNPEVLMVESDHDMRNSADFLVINKIAKAIFAVEGISRVQAITRPDGKPIEHTSIPFLISMQGTSQKLTEKYNQDLTARMLEQVNDIQSNIDQMERMHSLTQQMADVTHEMVIQMTGMVVDVEELRNHIADFDDFFRPIRSYFYWEKHCYDIPVCWSLRSVFDTLDGIDVMTEDINNLLPLMQRLDTLMPQLTAMMPEMIQTMKSMKAQMLSMHSTQEGLQDQMAAMQEDSAAMGEAFDASRNDDSFYLPPEVFDNPDFQRGLEQFLSPDGHAVRFIISHEGDPMSQAGIARIAKIKTAAKEAIKGTPLEGSAIYLGGTAAMFKDLSDGNTYDLMIAGISALCLIFIIMLIITRSVVAAAVIVGTVVLSLGASFGLSVLIWQHILGIELHWLVLAMAVIILLAVGADYNLLLVARLKEEIHAGINTGIIRAMGGSGSVVTAAGLVFAFTMMSFAVSELTVMAQVGTTIGMGLLFDTLIVRSFMTPSIAALLGKWFWWPQVVRQRPVPQPWPSPASARTFALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFM9</accession>
    <name>A0A7U8TFM9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol acetyltransferase</fullName>
            <shortName evidence="2">MSH acetyltransferase</shortName>
            <ecNumber evidence="2">2.3.1.189</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Mycothiol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mshD</name>
        <name evidence="4" type="ORF">TBLG_02965</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = CoA + H(+) + mycothiol</text>
            <dbReference type="Rhea" id="RHEA:26172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16768"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
            <dbReference type="EC" id="2.3.1.189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. MshD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.189" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404307.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFM9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035447">
        <property type="term" value="F:mycothiol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01698">
        <property type="entry name" value="MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017813">
        <property type="entry name" value="Mycothiol_AcTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021524">
        <property type="entry name" value="MSH_acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03448">
        <property type="entry name" value="mycothiol_MshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="152"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 1" evidence="2">
        <location>
            <begin position="88"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="238"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="245"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding 2" evidence="2">
        <location>
            <begin position="287"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>1D-myo-inositol 2-(L-cysteinylamino)-2-deoxy-alpha-D-glucopyranoside</name>
            <dbReference type="ChEBI" id="CHEBI:58887"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="315" mass="33599" checksum="E1728C0652CF2716" modified="2021-06-02" version="1">MTALDWRSALTADEQRSVRALVTATTAVDGVAPVGEQVLRELGQQRTEHLLVAGSRPGGPIIGYLNLSPPRGAGGAMAELVVHPQSRRRGIGTAMARAALAKTAGRNQFWAHGTLDPARATASALGLVGVRELIQMRRPLRDIPEPTIPDGVVIRTYAGTSDDAELLRVNNAAFAGHPEQGGWTAVQLAERRGEAWFDPDGLILAFGDSPRERPGRLLGFHWTKVHPDHPGLGEVYVLGVDPAAQRRGLGQMLTSIGIVSLARRLGGRKTLDPAVEPAVLLYVESDNVAAVRTYQSLGFTTYSVDTAYALAGTDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFS0</accession>
    <name>A0A7U8TFS0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Resuscitation-promoting factor rpfA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040010">
        <property type="term" value="P:positive regulation of growth rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030711077" evidence="3">
        <location>
            <begin position="34"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Transglycosylas" evidence="4">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="271"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="408" mass="40288" checksum="70919E7EBAEDC3D9" modified="2021-06-02" version="1" fragment="single">MSGRHRKPTTSNVSVAKIAFTGAVLGGGGIAMAAQATAATDGEWDQVARCESGGNWSINTGNGYLGGLQFTQSTWAAHGGGEFAPSAQLASREQQIAVGERVLATQGRGAWPVCGRGLSNATPREVLPASAAMDAPLDAAAVNGEPAPLAPPPADPAPPVELAANDLPAPLGEPLPAAPADPAPPADLAPPAPADVAPPVELAVNDLPAPLGEPLPAAPADPAPPADLAPPAPADLAPPAPADLAPPAPADLAPPVELAVNDLPAPLGEPLPAAPAELAPPADLAPASADLAPPAPADLAPPAPAELAPPAPADLAPPAAVNEQTAPGDQPATAPGGPVGLATDLELPEPDPQPADAPPPGDVTEAPAETPQVSNIAYTKKLWQAIRATGRLRQRCAGLARTAVRHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFS1</accession>
    <name>A0A7U8TFS1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-hydroxyacyl-CoA dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:22432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.35" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404426.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFS1"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="9">
        <location>
            <begin position="328"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="8">
        <location>
            <begin position="508"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="720" mass="76104" checksum="52CB1865400F3BE5" modified="2021-06-02" version="1">MPDNTIQWDKDADGIVTLTMDDPSGSTNVMNEAYIESMGKAVDRLVAEKDSITGVVVASAKKTFFAGGDVKTMIQARPEDAGDVFNTVETIKRQLRTLETLGKPVVAAINGAALGGGLEIALACHHRIAADVKGSQLGLPEVTLGLLPGGGGVTRTVRMFGIQNAFVSVLAQGTRFKPAKAKEIGLVDELVATVEELVPAAKAWIKEELKANPDGAGVQPWDKKGYKMPGGTPSSPGLAAILPSFPSNLRKQLKGAPMPAPRAILAAAVEGAQVDFDTASRIESRYFASLVTGQVAKNMMQAFFFDLQAINAGGSRPEGIGKTPIKRIGVLGAGMMGAGIAYVSAKAGYEVVLKDVSLEAAAKGKGYSEKLEAKALERGRTTQERSDALLARITPTADAADFKGVDFVIEAVFENQELKHKVFGEIEDIVEPNAILGSNTSTLPITGLATGVKRQEDFIGIHFFSPVDKMPLVEIIKGEKTSDEALARVFDYTLAIGKTPIVVNDSRGFFTSRVIGTFVNEALAMLGEGVEPASIEQAGSQAGYPAPPLQLSDELNLELMHKIAVATRKGVEDAGGTYQPHPAEAVVEKMIELGRSGRLKGAGFYEYADGKRSGLWPGLRETFKSGSSQPPLQDMIDRMLFAEALETQKCLDEGVLTSTADANIGSIMGIGFPPWTGGSAQFIVGYSGPAGTGKAAFVARARELAAAYGDRFLPPESLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFT8</accession>
    <name>A0A7U8TFT8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="68" mass="6653" checksum="55844DBA22E1C3B8" modified="2021-06-02" version="1">MILGIGIGGAGGDGGGALGVLGGNGRRRRRRRRGRSGWDRRGAVPAVPAAPPPPVTVALAATAATPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFU5</accession>
    <name>A0A7U8TFU5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component system transcriptional regulator prrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03057</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404690.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFU5"/>
    <dbReference type="GeneID" id="45424866"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="137"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="137"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="236" mass="25254" checksum="9510F7C4E522D8BE" modified="2021-06-02" version="1">MGGMDTGVTSPRVLVVDDDSDVLASLERGLRLSGFEVATAVDGAEALRSATENRPDAIVLDINMPVLDGVSVVTALRAMDNDVPVCVLSARSSVDDRVAGLEAGADDYLVKPFVLAELVARVKALLRRRGSTATSSSETITVGPLEVDIPGRRARVNGVDVDLTKREFDLLAVLAEHKTAVLSRAQLLELVWGYDFAADTNVVDVFIGYLRRKLEAGGGPRLLHTVRGVGFVLRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFY0</accession>
    <name>A0A7U8TFY0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404775.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFY0"/>
    <dbReference type="GeneID" id="45424894"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031496439" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="23"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="49"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="4">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002756-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="370" mass="37953" checksum="7D557829A9A118E0" modified="2021-06-02" version="1">MKLNRFGAAVGVLAAGALVLSACGNDDNVTGGGATTGQASAKVDCGGKKTLKASGSTAQANAMTRFVNVFEQACPGQTLNYTANGSGAGISEFNGNQTDFGGSDVPLSKDEAAAAQRRCGSPAWNLPVVFGPIAVTYNLNSVSSLNLDGPTLAKIFNGSITQWNNPAIQALNRDFTLPGERIHVVFRSDESGTTDNFQRYLQAASNGAWGKGAGKSFQGGVGEGARGNDGTSAAAKNTPGSITYNEWSFAQAQHLTMANIVTSAGGDPVAITIDSVGQTIAGATISGVGNDLVLDTDSFYRPKRPGSYPIVLATYEIVCSKYPDSQVGTAVKAFLQSTIGAGQSGLGDNGYIPIPDEFKSRLSTAVNAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG06</accession>
    <name>A0A7U8TG06_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein lprP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898662.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032018">
        <property type="entry name" value="LppA/LppB/LprP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16708">
        <property type="entry name" value="LppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030986944" evidence="6">
        <location>
            <begin position="26"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="224" mass="24415" checksum="608373B8B8A402FB" modified="2021-06-02" version="1">MKRTSRSLTAALLGIAALLAGCIKPNTFDPYANPGRGELDRRQKIVNGRPDLETVQQQLANLDATIRAMIAKYSPQTRFSTGVTVSHLTNGCNDPFTRTIGRQEASELFFGRPAPTPQQWLQIVTELAPVFKAAGFRPNNSVPGDPPQPLGAPNYSQIRDDGVTINLVNGDNRGPLGYSYNTGCHLPAAWRTAPPPLNMRPANDPDVHYPYLYGSPGGRTRDAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG21</accession>
    <name>A0A7U8TG21_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03145</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG21"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="246"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="504" mass="54432" checksum="06AD7E74E9549F4A" modified="2021-06-02" version="1">MWWFRRRDRAPLRATSSLSLRWRVMLLAMSMVAMVVVLMSFAVYAVISAALYSDIDNQLQSRAQLLIASGSLAADPGKAIEGTAYSDVNAMLVNPGQSIYTAQQPGQTLPVGAAEKAVIRGELFMSRRTTADQRVLAIRLTNGSSLLISKSLKPTEAVMNKLRWVLLIVGGIGVAVAAVAGGMVTRAGLRPVGRLTEAAERVARTDDLRPIPVFGSDELARLTEAFNLMLRALAESRERQARLVTDAGHELRTPLTSLRTNVELLMASMAPGAPRLPKQEMVDLRADVLAQIEELSTLVGDLVDLSRGDAGEVVHEPVDMADVVDRSLERVRRRRNDIHFDVEVIGWQVYGDTAGLSRMALNLMDNAAKWSPPGGHVGVRLSQLDASHAELVVSDRGPGIPVQERRLVFERFYRSASARALPGSGLGLAIVKQVVLNHGGLLRIEDTDPGGQPPGTSIYVLLPGRRMPIPQLPGATAGARSTDIENSRGSANVISVESQSTRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG52</accession>
    <name>A0A7U8TG52_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Two component system transcriptional regulator trcR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405328.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG52"/>
    <dbReference type="GeneID" id="45425007"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="33"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="158"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="158"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="257" mass="29209" checksum="164B4DF50FDA80A9" modified="2021-06-02" version="1">MTTMSGYTRSQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMALHYEGWDVEVAHDGQEAIAKFDKVGPDVLVLDIMLPDVDGLEILRRVRESDVYTPTLFLTARDSVMDRVTGLTSGADDYMTKPFSLEELVARLRGLLRRSSHLERPADEALRVGDLTLDGASREVTRDGTPISLSSTEFELLRFLMRNPRRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDSDREPMIHTVRGIGYMLRPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG71</accession>
    <name>A0A7U8TG71_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900263.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG71"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="25"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="NTP_transf_9" evidence="1">
        <location>
            <begin position="142"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="254" mass="28946" checksum="E08907398378AB2F" modified="2021-06-02" version="1">MSVDYPQMAATRGRIEPAPRRVRGYLGHVLVFDTSAARYVWEVPYYPQYYIPLADVRMEFLRDENHPQRVQLGPSRLHSLVSAGQTHRSAARVFDVDGDSPVAGTVRFNWDPLRWFEEDEPIYGHPRNPYQRADALRSHRHVRVELDGIVLADTRSPVLLFETGIPTRYYIDPADIAFEHLEPTSTQTLCPYKGTTSGYWSVRVGDAVHRDLAWTYHYPLPAVAPIAGLVAFYNEKVDLTVDGVALPRPHTQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGD2</accession>
    <name>A0A7U8TGD2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved alanine and proline rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406066.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003882">
        <property type="entry name" value="Pistil_extensin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01218">
        <property type="entry name" value="PSTLEXTENSIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030851891" evidence="2">
        <location>
            <begin position="45"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="371" mass="36480" checksum="C90E100833511CF9" modified="2021-06-02" version="1">MRRLTNTEHRENTTVASTWSVCKGLAAVVITSAAAFALCPNAAADPATPQPNPTQQLPGLPALAQLSPIIQQAAMNPAQATQLLMAAASAFAGNPAVPTESKNVASSVNQFVAEPTNPDSAALGVPAPHGVALPEAIPVPHVPPLGAEPGVQAHLPTGIDPSHAAGPAPAVAPTVTPPVAAPPASAPAPAPDAAQPVAVPGPPPAPPAPRAAAPAPASAAPAPAAAPAPASGFGADAPPTQDFMYPSIGPNCVADGSNSIATALSVAGPAKIPLPGPGPGQTAYVFTAVGTPGPADVQRLPLNVTWVNLTTGKSGSATLRPRSDINPDGPTTLTVIADTGSGSIMSTIFGQVTTKDRQCQFMPTIGSTVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGD6</accession>
    <name>A0A7U8TGD6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Respiratory nitrate reductase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TBLG_03340</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406095.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGD6"/>
    <dbReference type="GeneID" id="45425136"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="9"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD12756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="246" mass="28058" checksum="B40514EF7FC6F92F" modified="2021-06-02" version="1">MAVLDLVEIFWDAAPYVVVAIAVVGTWWRYRYDKFGWTTRSSQLYESRLLSIGSPMFHFGSLLVIMGHVMGLFIPDSWTRAFGMSDHLYHLQALLLGAPAGFATLLGIGLLIYRRRIQTPVWLATTRNDKLMYLVLVCAIVAGLACTLMGATHEGDMHDYRRSVSVWFRSIWMLAPRGDLMAQATLYYQVHVLIALALFALWPFTRLVHAFSAPIAYLFRPYIVYRSREVAAKHELIGSAPRRRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGD7</accession>
    <name>A0A7U8TGD7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03313</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="166" mass="19025" checksum="3305BF310B4B2750" modified="2021-06-02" version="1">MYYLLILAVVFERLAELVVAQRNARWSFAQGGKEFGRPHYVVMVILHTALLLGCVVEPWALHRPFIPWLGWPMLAVVVASQGLRWWCVKSLGKRWNTRVIVLPHATLVRRGPYRWMRHPNYVAVVAEGFALPLVHTAWLTTLVFTLANATLLTVRLRVENSVLGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGH1</accession>
    <name>A0A7U8TGH1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tetronasin-transport ATP-binding protein ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03394</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGH1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="10"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="311" mass="33476" checksum="6F6CF4E70D03D75B" modified="2021-06-02" version="1">MSADNHQVPIEIRGLTKHFGSVRALDGLDLTVREGEVHGFLGPNGAGKSTTLRILLGLVKADGGSVRLLGGDPWTDAVDLHRHIAYVPGDVTLWPSLTGGETIDLLARMRGGIDNARRAELIERFGLDPTKKARTYSKGNRQKVSLISALSSHATLLLLDEPSSGLDPLMENVFQQCIGEARQRGVTVLLSSHILAETEALCEKVTIIRAGKTVESGSLDALRHLSRTSIKAEMIGDPGDLSRIKGVEDISIEGTTVRAQVDSESLRELIQVLGHAGVRSLVSQPPTLEELFLRHYSLGPEVAAEQQVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGK1</accession>
    <name>A0A7U8TGK1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable conserved integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="280" mass="29394" checksum="F33F7AF21B011298" modified="2021-06-02" version="1">MRIGRREGLAVAIGFVLVGAAFVLPRLNLGIKPRSDIGLERFATRAGAAPIFGYWDAHVGWGTAPAVLTAVAVVAWGPVVAHRLPWRVLTLSTWATAAAWAFSLAMIDGWQRGFAGRLTTRDEYLWQVPGIADIPATLRTFTSRILDFQPNSWVTHVSGHPPGALLTFVWLDRIGLRGGGWAGLVCLLVGSSAAAAVLIAVRVLASEQMARRTAPFVAVAPTAIWIAVSADGYFAGVAAWGIALLAGAGAWVPLAFPALVAARSGATARLGCLFSTTGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGL0</accession>
    <name>A0A7U8TGL0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402929.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="171" mass="18800" checksum="88E6540119F22C71" modified="2021-06-02" version="1">MISPKPLLHILIHGRSDELPDTRGRIVLRWLRIAVLIVTGLVTLQSVLLVAGAWRNDIAIQRNMGVAQAEVLSAGPRRSTIEFVTPDRITYRPQLGVLYPSELSTGMRIYVEYNKRDPNLVRVQHRNAGLAIIPAGSIAVVAWLIAAAALVVLAVLDKRLERRENSASATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGL1</accession>
    <name>A0A7U8TGL1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dehydrogenase FAD flavoprotein gmc oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406598.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGL1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="PTHR11552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="GMC_OxRdtase_N" evidence="7">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="528" mass="57331" checksum="9177AD391F994CB6" modified="2021-06-02" version="1">MDTQSDYVVVGTGSAGAVVASRLSTDPATTVVALEAGPRDKNRFIGVPAAFSKLFRSEIDWDYLTEPQPELDGREIYWPRGKVLGGSSSMNAMMWVRGFASDYDEWAARAGPRWSYADVLGYFRRIENVTAAWHFVSGDDSGVTGPLHISRQRSPRSVTAAWLAAARECGFAAARPNSPRPEGFCETVVTQRRGARFSTADAYLKPAMRRKNLRVLTGATATRVVIDGDRAVGVEYQSDGQTRIVYARREVVLCAGAVNSPQLLMLSGIGDRDHLAEHDIDTVYHAPEVGCNLLDHLVTVLGFDVEKDSLFAAEKPGQLISYLLRRRGMLTSNVGEAYGFVRSRPELKLPDLELIFAPAPFYDEALVPPAGHGVVFGPILVAPQSRGQITLRSADPHAKPVIEPRYLSDLGGVDRAAMMAGLRICARIAQARPLRDLLGSIARPRNSTELDEATLELALATCSHTLYHPMGTCRMGSDEASVVDPQLRVRGVDGLRVADASVMPSTVRGHTHAPSVLIGEKAADLIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGN0</accession>
    <name>A0A7U8TGN0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="10">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">atpA</name>
        <name evidence="14" type="ORF">TBLG_03490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="10"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406699.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGN0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="13">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="11">
        <location>
            <begin position="152"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab_C" evidence="12">
        <location>
            <begin position="382"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="172"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="10">
        <location>
            <position position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="549" mass="59288" checksum="20C1A10AE661957A" modified="2021-06-02" version="1">MAELTIPADDIQSAIEEYVSSFTADTSREEVGTVVDAGDGIAHVEGLPSVMTQELLEFPGGILGVALNLDEHSVGAVILGDFENIEEGQQVKRTGEVLSVPVGDGFLGRVVNPLGQPIDGRGDVDSDTRRALELQAPSVVHRQGVKEPLQTGIKAIDAMTPIGRGQRQLIIGDRKTGKTAVCVDTILNQRQNWESGDPKKQVRCVYVAIGQKGTTIAAVRRTLEEGGAMDYTTIVAAAASESAGFKWLAPYTGSAIAQHWMYEGKHVLIIFDDLTKQAEAYRAISLLLRRPPGREAYPGDVFYLHSRLLERCAKLSDDLGGGSLTGLPIIETKANDISAYIPTNVISITDGQCFLETDLFNQGVRPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAFAAFASDLDAASKAQLERGARLVELLKQPQSQPMPVEEQVVSIFLGTGGHLDSVPVEDVRRFETELLDHMRASEEEILTEIRDSQKLTEEAADKLTEVIKNFKKGFAATGGGSVVPDEHVEALDEDKLAKEAVKVKKPAPKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGP0</accession>
    <name>A0A7U8TGP0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="104" mass="11632" checksum="4345CC96263DFBEC" modified="2021-06-02" version="1">MCFGQGEKGKQALDRWISWAQRCRIPVFVELAARIKRHRVAIDAALDHGLSQGLIESTNTKIRLLTRIAFGFRSPQALIALAMLTLAGHRPTLPGRHNHPQISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGP2</accession>
    <name>A0A7U8TGP2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Threonine synthase</fullName>
            <ecNumber evidence="6 10">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TBLG_03477</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="6 10"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026260">
        <property type="entry name" value="Thr_Synthase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038945">
        <property type="entry name" value="Thr_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 10 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="14">
        <location>
            <begin position="33"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="11">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="cross-link" description="Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)" evidence="13">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR038945-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD12893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="360" mass="37352" checksum="42627F594C5774B3" modified="2021-06-02" version="1">MTVPPTATHQPWPGVIAAYRDRLPVGDDWTPVTLLEGGTPLIAATNLSKQTGCTIHLKVEGLNPTGSFKDRGMTMAVTDALAHGQRAVLCASTGNTSASAAAYATRAGITCAVLIPQGKIAMGKLAQAVMHGAKIIQIDGNFDDCLELARKMAADFPTISLVNSVNPVRIEGQKTAAFEIVDVLGTAPDVHALPVGNAGNITAYWKGYTEYHQLGLIDKLPRMLGTQAAGAAPLVLGEPVSHPETIATAIRIGSPASWTSAVEAQQQSKGRFLAASDEEILAAYHLVARVEGVFVEPASAASIAGLLKAIDDGWVARGSTVVCTVTGNGLKDPDTALKDMPSVSPVPVDPVAVVEKLGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGR9</accession>
    <name>A0A7U8TGR9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03551</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGR9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="1">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="177"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="2">
        <location>
            <begin position="559"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="653" mass="69582" checksum="E6205AA55F588959" modified="2021-06-02" version="1">MAAEMDWDKTVGAAEDVRRIFEHIPAILVGLEGPDHRFVAVNAAYRGFSPLLDTVGQPAREVYPELEGQQIYEMLDRVYQTGEPQSGSEWRLQTDYDGSGVEERYFDFVVTPRRRADGSIEGVQLIVDDVTSRVRARQAAEARVEELSERYRNVRDSATVMQQALLAASVPVVPGADIAAEYLVAAEDTAAGGDWFDALALGDRLVLVVGDVVGHGVEAAAVMSQLRTALRMQISAGYTVVEALEAVDRFHKQVPGSKSATMCVGSLDFTSGEFQYCTAGHPPPLLVTADASARYVEPTGAGPLGSGTGFPVRSEVLNIGDAILFYTDGLIERPGRPLEASTAEFADLAASIASGSGGFVLDAPARPIDRLCSDTLELLLRSTGYNDDVTLLAMQRRAPTPPLHITLDATINAARTVRAQLREWLAEIGADHSDIADIVHAISEFVENAVEHGYATDVSKGIVVEAALAGDGNVRASVIDRGQWKDHRDGARGRGRGLAMAEALVSEARIMHGAGGTTATLTHRLSRPARFVTDTMVRRAAFQQTIDSEFVSLVESGRIVVRGDVDSTTAATLDRQIAVESRSGIAPVTIDLSAVTHLGSAGVGALAAACDRARKQGTECVLVAPPGSPAHHVLSLVQLPVVGADTEDIFAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGT5</accession>
    <name>A0A7U8TGT5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0336 protein TBLG_02774</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0336 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403282.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGT5"/>
    <dbReference type="GeneID" id="45424596"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00799">
        <property type="entry name" value="UPF0336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="MaoC-like_dehydrat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016709">
        <property type="entry name" value="UPF0336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="MaoC_dehydrat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018072">
        <property type="entry name" value="UCP018072"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC_dehydrat_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="166" mass="18930" checksum="71BE5CF102B02BDA" modified="2021-06-02" version="1">MALKTDIRGMIWRYPDYFIVGREQCREFARAVKCDHPAFFSEEAAADLGYDALVAPLTFVTILAKYVQLDFFRHVDVGMETMQIVQVDQRFVFHKPVLAGDKLWARMDIHSVDERFGADIVVTRNLCTNDDGELVMEAYTTLMGQQGDGSARLKWDKESGQVIRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGU9</accession>
    <name>A0A7U8TGU9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SUN protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGU9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="7">
        <location>
            <begin position="174"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="276"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD13011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="457" mass="48493" checksum="D97DEFCDBABA891D" modified="2021-06-02" version="1">MTPRSRGPRRRPLDPARRAAFETLRAVSARDAYANLVLPALLAQRGIGGRDAAFATELTYGTCRARGLLDAVIGAAAERSPQAIDPVLLDLLRLGTYQLLRTRVDAHAAVSTTVEQAGIEFDSARAGFVNGVLRTIAGRDERSWVGELAPDAQNDPIGHAAFVHAHPRWIAQAFADALGAAVGELEAVLASDDERPAVHLAARPGVLTAGELARAVRGTVGRYSPFAVYLPRGDPGRLAPVRDGQALVQDEGSQLVARALTLAPVDGDTGRWLDLCAGPGGKTALLAGLGLQCAARVTAVEPSPHRADLVAQNTRGLPVELLRVDGRHTDLDPGFDRVLVDAPCTGLGALRRRPEARWRRQPADVAALAKLQRELLSAAIALTRPGGVVLYATCSPHLAETVGAVADALRRHPVHALDTRPLFEPVLAGLGEGPHVQLWPHRHGTDAMFAAALRRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGV1</accession>
    <name>A0A7U8TGV1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02804</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403405.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGV1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="5">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="112" mass="11590" checksum="ED398523D598FDF9" modified="2021-06-02" version="1">MTEGEVGVGLLDTSVFIARESGGAIADLPERVALSVMTIGELQLGLLNAGDSATRSRRADTLALARTADQIPVSEAVMISLARLVADCRAAGVRRSVKLTDALIAATAEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGW3</accession>
    <name>A0A7U8TGW3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein mmpS5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MmpS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403439.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGW3"/>
    <dbReference type="GeneID" id="45424639"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008693">
        <property type="entry name" value="MmpS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038468">
        <property type="entry name" value="MmpS_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05423">
        <property type="entry name" value="Mycobact_memb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="142" mass="15249" checksum="055BD99A3F46E8F5" modified="2021-06-02" version="1">MIGTLKRAWIPLLILVVVAIAGFTVQRIRTFFGSEGILVTPKVFADDPEPFDPKVVEYEVSGSGSYVNINYLDLDAKPQRIDGAALPWSLTLKTTAPSAAPNILAQGDGTSITCRITVDGEVKDERTATGVDALTYCFVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGZ3</accession>
    <name>A0A7U8TGZ3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="177"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="351"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD13033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="422" mass="46957" checksum="EC7F9D9078751F00" modified="2021-06-02" version="1">MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMADLWRASITENFVTAVHYLDRDTPQSLVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAGELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVGDGLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH00</accession>
    <name>A0A7U8TH00_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031293163" evidence="1">
        <location>
            <begin position="34"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD13048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="122" mass="12018" checksum="56AC0525262F37EB" modified="2021-06-02" version="1" fragment="single">MSNVMVVPGMLSAAAADVASIGAALSAANGAAAPTTAGVLAAGADEVSAAIASLFSGYARDYQALSAQMARFHQQFVQALTASVGSYAAAEAANASPLQALEQQVLAAINAPTQTLLGRPLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THM4</accession>
    <name>A0A7U8THM4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405514.1">
        <property type="nucleotide sequence ID" value="NZ_KK338665.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THM4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="341" mass="36089" checksum="2C78E17F8964BF41" modified="2021-06-02" version="1">MCAHQFFGLVHNPVVAAAIGKPEPPPVDSDIGLPTTVPFEPWSVADFSRYLSTLGLPAAGDAVTLHRILSSMERAGLLLPLGWDPRLPVMGQKYISQGAISKGQRGGNLWLSEVFGAELIIPSYNAVTVQLAGHDDAGNPVDSWGTGLVVDHNHVITNKHVVTGLAGTSAGLSVYPSSNHAEAELVNFSGTAHPHPTLDVAVIKFEMPEGKYIPRLGGMAFRDPDWADEVYVFGYPRVPMTAEMAITVQRGEVVNPAATTIPGRQKIFLYSAIARPGNSGGPIVAQDGRVIGLVVEDSAEAPSTGTGPNAAPFYRGIPSSEVIRALDELDFGGIVEMDTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THU3</accession>
    <name>A0A7U8THU3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03076</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016547">
        <property type="entry name" value="UCP009158"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014795">
        <property type="entry name" value="Vibrio_phage_ICP1_Orf50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35401">
        <property type="entry name" value="PTHR35401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08681">
        <property type="entry name" value="DUF1778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009158">
        <property type="entry name" value="UCP009158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="158" mass="17358" checksum="6906C98A3E7F47F3" modified="2021-06-02" version="1">MHRAGAAVTANVWCRAGGIRMAPRPVIPVATQQRLRRQADRQSLGGSGLPALNCTPIRHTIDVMATKPERKTERLAARLTPEQDALIRRAAEAEGTDLTNFTVTAALAHARDVLADRRLFVLTDAAWTEFLAALDRPVSHKPRLEKLFAARSIFDTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI13</accession>
    <name>A0A7U8TI13_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase_C39_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898800.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI13"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039564">
        <property type="entry name" value="Peptidase_C39-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13529">
        <property type="entry name" value="Peptidase_C39_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030760334" description="Peptidase_C39_2 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_C39_2" evidence="2">
        <location>
            <begin position="47"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="232" mass="23974" checksum="76AC21DDE5573B98" modified="2021-06-02" version="1">MTTSKIATAFKTATFALAAGAVALGLASPADAAAGTMYGDPAAAAKYWRQQTYDDCVLMSAADVIGQVTGREPSERAIIKVAQSTPSVVHPGSIYTKPADAEHPNSGMGTSVADIPTLLAHYGVDAVITDEDHATATGVATGMAALEQYLGSGHAVIVSINAEMIWGQPVEETDSAGNPRSDHAVVVTGVDTENGIVHLNDSGTPTGRDEQIPMETFVEAWATSHDFMAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI46</accession>
    <name>A0A7U8TI46_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03275</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898727.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425075"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="385" mass="41717" checksum="7468D37557C66B10" modified="2021-06-02" version="1">MNTEFTLTQKRALAILTLIALLFGAYFLRNYFVLIVVAAVGAYLFTPLFKWFTKRFNTGLSAACTLLSALAAVVVPVGALVGLAIVQIARMVDSVADWVRTTDLSTLGDKILQFVNGLFDRVPFLHITVTADALRKAMISVAQNVGEWLLHFLRDAAGSLAGVITSAIIFVYVFVALLVNREKLRTLIGQLNPLGEDVTDLYLQKMGSMVRGTVNGQFVIAACQGVAGAASIYIAGFHHGFFIFAIVLTALSIIPLGGGIVTIPFGIGMIFYGNIAGGIFVLLWHLLVVTNIDNVLRPILVPRDARLNSALMLLSVFAGITMFGPWGIIIGPVLMILIVTTIDVYLAVYKGVELEQFEAPPVRRRWLPRRGPATSRNAPPPSTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI86</accession>
    <name>A0A7U8TI86_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase echA10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405957.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI86"/>
    <dbReference type="GeneID" id="45425115"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="268" mass="27649" checksum="8EFA8FF161FD8DC0" modified="2021-06-02" version="1">MSNYRIDTRTIVPGLAVTLADGVLSVTIDRPESLNSLTKPVLAGMADAIEGAATDPRVKVVRLGGAGRGFSSGGAISVDDVWASGPPTDTVAEANRTVRAIVALPQPVVAVVQGPTVGCGVSLALACDLVLASDNAFFMLAHTNVGLMPDGGASALVQAAIGRIRAMHMALLPDRVPAAEALSWGLVSAVYPAADFDAEVDKLISRLLAGPALAIAKTKNAINAATLTELAPTLLRELDGQALLLRTDDFAEGATAFQQRRTPMFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI89</accession>
    <name>A0A7U8TI89_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">F420 biosynthesis protein fbiC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01612">
        <property type="entry name" value="FO_synth_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019940">
        <property type="entry name" value="CofH_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00293">
        <property type="entry name" value="((2_3_4_5-tetrahydroxypentyl)a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03551">
        <property type="entry name" value="F420_cofH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="184"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="496" mass="53214" checksum="18A46F79B289043E" modified="2021-06-02" version="1">RPTMSTPNGPGPALDELAAVTAEAGYDMVQRLTAQPKYVQAGAAWIDPRVRGHVVALADPATGLARDVNPVGMPWQEPDDVASWGRVDLGAAIDTQGRNTAVRSDLASAFGDWESIREQVHELAVRAPERIDTDVLAALRSAERAPAGCTDGEYLALATADGPALEAVAALADSLRRDVVGDEVTFVVNRNINFTNICYTGCRFCAFAQRKGDADAYSLSVGEVADRAWEAHVAGATEVCMQGGIDPELPVTGYADLVRAVKARVPSMHVHAFSPMEIANGVTKSGLSIREWLIGLREAGLDTIPGTAAEILDDEVRWVLTKGKLPTSLWIEIVTTAHEVGLRSSSTMMYGHVDSPRHWVAHLNVLRDIQDRTGGFTEFVPLPFVHQNSPLYLAGAARPGPSHRDNRAVHALARIMLHGRISHIQTSWVKLGVRRTQVMLEGGANDLGGTLMEETISRMAGSEHGSAKTVAELVAIAEGIGRPARQRTTTYALLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIH4</accession>
    <name>A0A7U8TIH4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406680.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="161" mass="16895" checksum="35D2A16588ECF023" modified="2021-06-02" version="1">MTTPAQDAPLVFPSVAFRPVRLFFINVGLAAVAMLVAGVFGHLTVGMFLGLGLLLGLLNALLVRRSAESITAKEHPLKRSMALNSASRLAIITILGLIIAYIFRPAGLGVVFGLAFFQVLLVATTALPVLKKLRTATEEPVATYSSNGQTGGSEGRSASDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TII3</accession>
    <name>A0A7U8TII3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406857.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TII3"/>
    <dbReference type="GeneID" id="45425292"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="75"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="165" mass="17858" checksum="081F482D1E796E64" modified="2021-06-02" version="1">MIHYRTIDSPIGPLTLAGHGSVLTNLRMLEQTYEPSRTHWTPDPGAFSGAVDQLNAYFAGELTEFDVELDLRGTDFQQRVWKALLTIPYGETRSYGEIADQIGAPGAARAVGLANGHNPIAIIVPCHRVIGASGKLTGYGGGINRKRALLELEKSRAPADLTLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIU1</accession>
    <name>A0A7U8TIU1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016676">
        <property type="entry name" value="P_lipid/glycerol_AcTrfase_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016753">
        <property type="entry name" value="P_lipid/glycerol_ac_tran_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="56"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="275" mass="29928" checksum="D032B9F8AE625A8B" modified="2021-06-02" version="1">MSETDSPGNGDDAGIGDIGKFDPGLTQRLISVLRPVLKTYHRSQVHGLDSFPPGGALVVANHSGGMFPMDVPVFSVDFYDKFGYDRPVYTLSHDILFMGLTGDLFRRTGYIRATRENAAKALRSGGVVVVFPGGDYDAYRPTFAENVIDFNGRKGYDSTAVEAGVPIVPAVSIGGQESQLYLSRGTWLARRLGLKRLLRSDILPISFGFPFGFSAAIPPNLPLPAKIVMQVLDPINLTKQFGEDPDVDAVDEHVRSVMQQALNDLAAKRRFPILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRB7</accession>
    <name>A0A7U8TRB7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416584.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRB7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="188"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="423" mass="45831" checksum="1322B3DA444E1D9A" modified="2021-06-02" version="1">MIQTCEVELRWRASQLTLAIATCAGVALAAAVVAGRWQLIAFAAPLLGVLCSISWQRPVPVIQVHGDPDSQRCFENEHVRVTVWVTTESVDAAVELTVSALAGMQFEALESVSRRTTTVSAVAQRWGRYPIRARVAVVARGGLLMGAGTVDAAEIVVFPLTPPQSTPLPQTELLDRLGAHLTRHVGPGVEYADIRPYVPGDQLRAVNWVVSARRGRLHVTRRLTDRAADVVVLIDMYRQPAGPATEATERVVRGAAQVVQTALRNGDRAGIVALGGNRPRWLGADIGQRQFYRVLDTVLGAGEGFENTTGTLAPRAAVPAGAVVIAFSTLLDTEFALALIDLRKRGHVVVAVDVLDSCPLQDQLDPLVVRMWALQRSAMYRDMATIGVDVLSWPADHSLQQSMGALPNRRRRGRGRASRARLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRD6</accession>
    <name>A0A7U8TRD6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03805</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899953.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRD6"/>
    <dbReference type="GeneID" id="45427170"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="150" mass="16799" checksum="E987C6E7708019C5" modified="2021-06-02" version="1">MQLGRKVTSHHDIDRFGVASTADESVYRPLPPRLRLAQVNLSRRRCRTQSDMYKSRFSECTVQSVDVSVTELRAHLSDWLDRARAGGEVVITERGIPIARLAALDSTDTLERLTAEGVIGKATAQRPVAAGRPRPRPQRPVSDRVSDQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRE8</accession>
    <name>A0A7U8TRE8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03830</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRE8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="325"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="25"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD14932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1055" mass="110701" checksum="7038057CA67DBFF9" modified="2021-06-02" version="1">MSHIWGVEAGAALAPGLRGPVLVLGGPGTGKSTLLVEAAVAHIGAGTDPESVLLLTGSGRMGMRARSALTTALLRSRTNGPCRAAIREPVVRTVHSYAYAVLRKAAQRAGDALPRLLTSAEQDAIIRELLAGDAEDGPAATTTWPAHLRPALTTAGFATELRNLLARCAERGLDPLELQQLGRRRGRPEWIAAGQFAQRYEQVMLLRGAVGLAAPQATAPALSAAELVGAALEAFAVDPELLAAERARVRTLLVDDAQQLDPQAARLVRMLAAGTELALIAGDPNQAVFGFRGGEPTGLLADDPPPAGGAPIPSVTLTVSHRCAPAVARAVTGIARRLPGRSVGRRIEGTGTEVGSVTVRLAGSAHAEAAMIADALRRAHLIDGVPWSQMAVIVRSVPRAVRLPRALAAAGVPVAPPAVGGPLSAEPAVRALLTVLEATADGLDGDQALLLLTGPIGGVDPVSLRQLRRTLQRARPGQTSRKFGDLLVEVLGGDAPPSGPGSRALRRVRAVLTAAARCHRSGSLGGQDPRHTLWAAWQRSGLQRRWLAASEHGGAAAVQATRDLETVTALFDITDHYVSRTSGASLRGLVEHVTALQLPVVRPEPAAPTEQVMVLSAHAALGHEWDLVVIAGLQDGLWPNTVPRGGVLGTQRLLDELDGVTKDASMRAPLLAEERRLLVTAMGRARRRLLVTAVDSDAGGGGHEAVLPSAFFFEIAQWADGDGEPVAMQPVSAPRVLSAAAVVGRLRAVVCAPACAVDDADRDCAATQLARLAKAGVPGADPSEWHGLAPVSTSDPLCDSDDLVTLTPSTLQALNDCPLRWLAERHGGTNTRELPSAVGSVLHALFAEPGRSESQLLAELDRVWGHLPFGAQWYSANELARHRAMIQAFVQWRAQSRSELTEVGVEVDIDGALEDGSGQARKIRLRGRADRLERDPAGRLVIVDIKTGKTPVSKDDAQQHAQLAMYQLAVAEGLVRAGDEPGGARLVYVGKSGAAGVAERKQDPLTPAARDEWRNLVRQLAAATAGPQFIARRNDGCTHCPLRPGCPAHVRGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRF6</accession>
    <name>A0A7U8TRF6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Linoleoyl-CoA desaturase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416919.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FA_desaturase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="427" mass="48443" checksum="56341F7F1B393A65" modified="2021-06-02" version="1">MAITDVDVFAHLTDADIENLAAELDAIRRDVEESRGERDARYIRRTIAAQRALEVSGRLLLAGSSRRLAWWTGALTLGVAKIIENMEIGHNVMHGQWDWMNDPEIHSSTWEWDMSGSSKHWRYTHNFVHHKYTNILGMDDDVGYGMLRVTRDQRWKRYNIFNVVWNTILAIGFEWGVALQHLEIGKIFKGRADREAAKTRLREFSAKAGRQVFKDYVAFPALTSLSPGATYRSTLTANVVANVIRNVWSNAVIFCGHFPDGAEKFTKTDMIGEPKGQWYLRQMLGSANFNAGPALRFMSGNLCHQIEHHLYPDLPSNRLHEISVRVREVCDRYDLPYTTGSFLVQYGKTWRTLAKLSLPDKYLRDNADDAPETRSERMFAGLGPGFAGADPVTGRRRGLKTAIAAVRGRRRSKRMAKSVTEPDDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRH7</accession>
    <name>A0A7U8TRH7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="3"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417054.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRH7"/>
    <dbReference type="GeneID" id="45427249"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="PTHR10309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="4">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="408" mass="43371" checksum="5D55B70C539E1C23" modified="2021-06-02" version="1">MELLRGALRTYAWGSRTAIAEFTGRPVPAAHPEAELWFGAHPGDPAWLQTPHGQTSLLEALVADPEGQLGSASRARFGDVLPFLVKVLAADEPLSLQAHPSAEQAVEGYLREERMGIPVSSPVRNYRDTSHKPELLVALQPFEALAGFREAARTTELLRALAVSDLDPFIDLLSEGSDADGLRALFTTWITAPQPDIDVLVPAVLDGAIQYVSSGATEFGAEAKTVLELGERYPGDAGVLAALLLNRISLAPGEAIFLPAGNLHAYVRGFGVEVMANSDNVLRGGLTPKHVDVPELLRVLDFAPTPKARLRPPIRREGLGLVFETPTDEFAATLLVLDGDHLGHEVDASSGHDGPQILLCTEGSATVHGKCGSLTLQRGTAAWVAADDGPIRLTAGQPAKLFRATVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRI2</accession>
    <name>A0A7U8TRI2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase lipV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRI2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="7"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="224" mass="23642" checksum="49BC00C437D99231" modified="2021-06-02" version="1">MPEIPIAAPDLLGHGRSPWAAPWTIDANVSALAALLDNQGDGPVVVVGHSFGGAVAMHLAAARPDQVAALVLLDPAVALDGSRVREVVDAMLASPDYLDPAEARAEKATGAWADVDPPVLDAELDEHLVALPNGRYGWRISLPAMVCYWSELARDIVLPPVGTATTLVRAVRASPAYVSDQLLAALDKRLGADFELLDFDCGHMVPQAKPTEVAAVIRSRLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRM4</accession>
    <name>A0A7U8TRM4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase lhr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="35"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="260"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1513" mass="161381" checksum="47C47C7F6A3931D7" modified="2021-06-02" version="1">MRFAQPSALSRFSALTRDWFTSTFAAPTAAQASAWAAIADGDNTLVIAPTGSGKTLAAFLWALDSLAGSEPMSERPAATRVLYVSPLKALAVDVERNLRTPLAGLTRLAERQGLPAPQIRVGVRSGDTPPALRRQLVSQPPDVLITTPESLFLMLTSAARQTLTGVQTVIIDEIHAIAATKRGAHLALSLERLDDLSSRRRAQRIGLSATVRPPEELARFLSGQSPTTIVAPPAAKTVELSVQVPVPDMANLTDNTIWPDVEARLVDLIESHNSTIVFANSRRLAERLTARLNEIHAARCGIELAPDTNQQVAGGAPAHIMGSGQTFGAPPVLARAHHGSISKEQRAVVEEDLKRGQLKAVVATSSLELGIDMGAVDLVIQVQAPPSVASGLQRIGRAGHQVGEISRGVLFPKHRTDLLGCAVSVQRMLAGEIETMRVPANPLDILAQHTVAAAALEPLDADAWFDTVRRAAPFATLPRSLFEATLDLLSGKYPSTEFAELRPRLVYDRDTGTLTARPGAQRLAVTSGGAIPDRGLFAVYLATERPSRVGELDEEMVYESRPGDVISLGATSWRITEITHDRVLVIPAPGQPARLPFWRGDDAGRPAELGAALGALTGELAALDRTAFGTRCAGLGFDDYATDNLWRLLDDQRTATAVVPTDSTLLVERFRDELGDWRVILHSPYGLRVHGPLALAVGRRLRDRYGIDEKPTASDNGIVVRLPDTVSAGEDSPPGAELFVFDADEIDPIVTTEVAGSALFASRFRESAARALLLPRRHPGRRSPLWQQRQRAARLLEVARKYPDFPIVLETVRECLQDVYDVPILVELMARIAQRRVRVAEAETAKPSPFAASLLFGYVGAFMYEGDTPLAERRAAALALDGTLLAELLGRVELRELLDPDVIAATSRQLQHLAADRVARDAEGVADLLRLLGPLTEDEIAARAGAPEVSGWLDGLRAAKRALVVSFAGRSWWVAVEDMGRLRDGVGAAVPVGLPASFTEAVADPLGELLGRYARTHTPFTTAAAAARFGLGLRVTADVLGRLASDGRLVRGEFVAAAEGSAGGEQWCDAEVLRILRRRSLAALRAQAEPVSTAAYGRFLPAWQHVSAGNSGIDGLAAVIDQLAGVRIPASAIEPLVLAPRIRDYSPAMLDELLASGDVTWSGAGSISGSDGWIALHPADSAPMTLAEPAEIDFTDAHRAILASLGTGGAYFFRQLTHDGLTEAELKAALWELIWAGRVTGDTFAPVRAVLGGAGTRKRAAPAHGGHRPPRLSRYRLTHAQARNADPTVAGRWSALPLPEPDSTLRAHYQAELLLNRHGVLTKDAVAAEGVAGGFATLYKVLSAFEDAGRCQRGYFIESLGGAQFAVASTVDRLRSYLDGVDPEQPDYHAVVLAAADPANPYGAALPWPASSADGTARPGRKAGALVVLVDGELAWFLERGGRSLLTFTDDPEANHAAAIGLADLVTAGRVASILVERADGMPVLQPGGRASAALTALLAAGFVRTPRGLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRS2</accession>
    <name>A0A7U8TRS2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TBLG_04030</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRS2"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="13">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="14">
        <location>
            <begin position="272"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD15132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="446" mass="48734" checksum="E2A0106352CC0D16" modified="2021-06-02" version="1">MAQLTALDAGFLKSRDPERHPGLAIGAVAVVNGAAPSYDQLKTVLTERIKSIPRCTQVLATEWIDYPGFDLTQHVRRVALPRPGDEAELFRAIALALERPLDPDRPLWECWIIEGLNGNRWAILIKIHHCMAGAMSAAHLLARLCDDADGSAFANNVDIKQIPPYGDARSWAETLWRMSVSIAGAVCTAAARAVSWPAVTSPAGPVTTRRRYQAVRVPRDAVDAVCHKFGVTANDVALAAITEGFRTVLLHRGQQPRADSLRTLEKTDGSSAMLPYLPVEYDDPVRRLRTVHNRSQQSGRRQPDSLSDYTPLMLCAKMIHALARLPQQGIVTLATSAPGPRHQLRLMGQKMDQVLPIPPTALQLSTGVAVLSYGDELVFGITADYDAASEMQQLVNGIELGVARLVALSDDSVLLFTKDRRKRSSRALPSAARRGRPSVPTARARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRT1</accession>
    <name>A0A7U8TRT1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04041</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417765.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRT1"/>
    <dbReference type="GeneID" id="45427359"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="122" mass="13423" checksum="7840FC2CB514B727" modified="2021-06-02" version="1">MSRPHPPVLTVRSDRSQQCFAAGRDVVVGSDLRADMRVAHPLIARAHLLLRFDRGNWIAIDNDSQSGMFVDGQRVSEVDIYDGLTINIGKPTGPWITFEVGHHQGIIGRLSRTPSSRPGSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRT9</accession>
    <name>A0A7U8TRT9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Penicillin-binding protein dacB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_04073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417415.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRT9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018044">
        <property type="entry name" value="Peptidase_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001967">
        <property type="entry name" value="Peptidase_S11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00768">
        <property type="entry name" value="Peptidase_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00725">
        <property type="entry name" value="DADACBPTASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030667911" evidence="10">
        <location>
            <begin position="33"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S11" evidence="11">
        <location>
            <begin position="88"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="6">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR618044-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD15179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="405" mass="41682" checksum="9CD518E7C18EFF05" modified="2021-06-02" version="1">MAFLRSVSCLAAAVFAVGTGIGLPTAAGEPNAAPAACPYKVSTPPAVDSSEVPAAGEPPLPLVVPPTPVGGNALGGCGIITAPGSAPAPGDVSAEAWLVADLDSGAVIAARDPHGRHRPASVIKVLVAMASINTLTLNKSVAGTADDAAVEGTKVGVNTGGTYTVNQLLHGLLMHSGNDAAYALARQLGGMPAALEKINLLAAKLGGRDTRVATPSGLDGPGMSTSAYDIGLFYRYAWQNPVFADIVATRTFDFPGHGDHPGYELENDNQLLYNYPGALGGKTGYTDDAGQTFVGAANRDGRRLMTVLLHGTRQPIPPWEQAAHLLDYGFNTPAGTQIGTLIEPDPSLMSTDRNPADRQRVDPQAAARISAADALPVRVGVAVIGALIVFGLIMVARAMNRRPQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRU8</accession>
    <name>A0A7U8TRU8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418284.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="237" mass="26877" checksum="5AE9591B2BC986AE" modified="2021-06-02" version="1">MADASVVARLRSWALAVWHFVSNAPLTYAWLVVLVITTIIQNNLTGSQLHFVLLHRSTNIAELGRDPLEVLFSSLLWIDGRNLEPYLLLFTLFLAPAEHWLGHLRWLTVGLTAHIGATYLSEGLLYLAIQHRDASERMVHARDIGVSYFLVGVMAVLTYHIAKPWRWGYLGVLLVIFGFPLIAMDKAELDFTAVGHFASILIGLLFYPMARERDGRLWNPARIKSLLHRRGTRGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRY8</accession>
    <name>A0A7U8TRY8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_04129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024282">
        <property type="entry name" value="DUF3376"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019894">
        <property type="entry name" value="Patatin-related_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11856">
        <property type="entry name" value="DUF3376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03607">
        <property type="entry name" value="TIGR03607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="951"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="996"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="245"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1021" mass="109316" checksum="0333712A47EA5AC0" modified="2021-06-02" version="1">MAGVTREINLLAQASQWRRLGGTFPTNSQLTNESAASLRLYAQLIDLLDMVVDVDILSGTSAGGINAALLASSRVTGSDLGGIRDLWLDLGALTELLRDPRDKKTPSLLYGDERIFAALAKRLPKLATGPFPPTTFPEAARTPSTTLYITTTLLAGETSRFTDSFGTLVQDVDRRGLFTFTETDLARPDTAPALALAARSSASFPLAFEPSFLPFTKGTAKKGEVPARPAMAPFTSLTRPHWVSDGGLLDNRPIGVLFKRIFDRPARRPVRRVLLFVVPSSGPAPDPMHEPPPDNVDEPLGLIDGLLKGLAAVTTQSIAADLRAIRAHQDCMEARTDAKLRLAELAATLRNGTRLLTPSLLTDYRTREATKQAQTLTSALLRRLSTCPPESGPATESLPKSWSAELTVGGDADKVCRQQITATILLSWSQPTAQPLPQSPAELARFGQPAYDLAKGCALTVIRAAFQLARSDADIAALAEVTEAIHRAWRPTASSDLSVLVRTMCSRPAIRQGSLENAADQLAADYLQQSTVPGDAWERLGAALVNAYPTLTQLAASASADSGAPTDSLLARDHVAAGQLETYLSYLGTYPGRADDSRDAPTMAWKLFDLATTQRAMLPADAEIEQGLELVQVSADTRSLLAPDWQTAQQKLTGMRLHHFGAFYKRSWRANDWMWGRLDGAGWLVHVLLDPRRVRWIVGERADTNGPQSGAQWFLGKLKELGAPDFPSPGYPLPAVGGGPAQHLTEDMLLDELGFLDDPAKPLPASIPWTALWLSQAWQQRVLEEELDGLANTVLDPQPGKLPDWSPTSSRTWATKVLAAHPGDAKYALLNENPIAGETFASDKGSPLMAHTVAKAAATAAGAAGSVRQLPSVLKPPLITLRTLTLSGYRVVSLTKGIARSTIIAGALLLVLGVAAAIQSVTVFGVTGLIAAGTGGLLVVLGTWQVSGRLLFALLSFSVVGAVLALATPVVREWLFGTQQQPGWVGTHAYWLGAQWWHPLVVVGLIALVAIMIAAANPGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TS03</accession>
    <name>A0A7U8TS03_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031411925" evidence="1">
        <location>
            <begin position="32"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="107" mass="11171" checksum="341B0CAA687204C3" modified="2021-06-02" version="1">MNIRCGLAAGAVICSAVALGIALHSGDPARALGPPPDGSYSFNQAGVSGVTWTITALCDQPSGTRNMNDYSDPIVWAFNCALNVVSTTPQQITRTDRLQNFSAGLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TS05</accession>
    <name>A0A7U8TS05_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900059.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TS05"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="100" mass="11120" checksum="5046B1B46578DC6C" modified="2021-06-02" version="1">MNADPVLSYNFDAIEYSVRQEIHTTAARFNAALQELRSQIAPLQQLWTREAAAAYHAEQLKWHQAASALNEILIDLGNAVRHGADDVAHADRRAAGAWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT25</accession>
    <name>A0A7U8TT25_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415983.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT25"/>
    <dbReference type="GeneID" id="45427047"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="184" mass="19095" checksum="043CF5A6D2146569" modified="2021-06-02" version="1">MSDTKSDIKILALVGSLRAASFNRQIAELAAKVAPDGVTVTMFEGLGDLPFYNEDIDTATEVPAPVSALREAASDAHAALVVTPEYNGSIPAVIKNAIDWLSRPFGDGALKDKPLAVIGGSMGRYGGVWAHDETRKSFSIAGTRVVDAIKLSVPFQTLGKSVADDAGLAANVRDAVGNLAAEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT44</accession>
    <name>A0A7U8TT44_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpf</name>
        <name evidence="4" type="ORF">TBLG_03879</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416957.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT44"/>
    <dbReference type="GeneID" id="45427235"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="155"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="214" mass="24567" checksum="32617A4AE68B9035" modified="2021-06-02" version="1">MDSGQVLAEPKSNAEIVFKGRNVEIPDHFRIYVSQKLARLERFDRTIYLFDVELDHERNRRQRKSCQRVEITARGRGPVVRGEACADSFYAALESAVVKLESRLRRGKDRRKVHYGDKTPVSLAEATAVVPAPENGFNTRPAEAHDHDGAVVEREPGRIVRTKEHPAKPMSVDDALYQMELVGHDFFLFYDKDTERPSVVYRRHAYDYGLIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT63</accession>
    <name>A0A7U8TT63_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Metal cation transporting P-type ATPase ctpC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899995.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT63"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="718" mass="76495" checksum="85D6C93AFE636315" modified="2021-06-02" version="1">MTLEVVSDAAGRMRVKVDWVRCDSRRAVAVEEAVAKQNGVRVVHAYPRTGSVVVWYSPRRADRAAVLAAIKGAAHVAAELIPARAPHSAEIRNTDVLRMVIGGVALALLGVRRYVFARPPLLGTTGRTVATGVTIFTGYPFLRGALRSLRSGKAGTDALVSAATVASLILRENVVALTVLWLLNIGEYLQDLTLRRTRRAISELLRGNQDTAWVRLTDPSAGSDAATEIQVPIDTVQIGDEVVVHEHVAIPVDGEVVDGEAIVNQSAITGENLPVSVVVGTRVHAGSVVVRGRVVVRAHAVGNQTTIGRIISRVEEAQLDRAPIQTVGENFSRRFVPTSFIVSAIALLITGDVRRAMTMLLIACPCAVGLSTPTAISAAIGNGARRGILIKGGSHLEQAGRVDAIVFDKTGTLTVGRPVVTNIVAMHKDWEPEQVLAYAASSEIHSRHPLAEAVIRSTEERRISIPPHEECEVLVGLGMRTWADGRTLLLGSPSLLRAEKVRVSKKASEWVDKLRRQAETPLLLAVDGTLVGLISLRDEVRPEAAQVLTKLRANGIRRIVMLTGDHPEIAQVVADELGIDEWRAEVMPEDKLAAVRELQDDGYVVGMVGDGINDAPALAAADIGIAMGLAGTDVAVETADVALANDDLHRLLDVGDLGERAVDVIRQNYGMSIAVNAAGLLIGAGGALSPVLAAILHNASSVAVVANSSRLIRYRLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTD8</accession>
    <name>A0A7U8TTD8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="5 10">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03671</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="5 10"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026459">
        <property type="entry name" value="RNR_1b_NrdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013554">
        <property type="entry name" value="RNR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="PTHR11573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08343">
        <property type="entry name" value="RNR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04170">
        <property type="entry name" value="RNR_1b_NrdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RIBORED_LARGE" evidence="11">
        <location>
            <begin position="577"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD14773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="726" mass="82284" checksum="2E7D1684F7669A51" modified="2021-06-02" version="1">MPPTVIAEPVASGAHASYSGGPGETDYHALNAMLNLYDADGKIQFDKDREAAHQYFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKTLLDRAYAKKFRFPTFLGAFKYYTSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTALAELLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLLRVEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHAHHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKRNDDMYLFSPYDVERVYGVPFADISVTEKYYEMVDDARIRKTKIKAREFFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLCSEILQVSTPSLFNEDLSYAKVGKDISCNLGSLNIAKTMDSPDFAQTIEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLARERIFYGSDEGIDFTNIYFYTVLYHALRASNRIAIERGTHFKGFERSKYASGEFFDKYTDQIWEPKTQKVRQLFADAGIRIPTQDDWRRLKESVQAHGIYNQNLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLEYYEDAYEIGYEKIIDTYAAATQHVDQGLSLTLFFKDTATHPRREQGADFTPGARGSRRCTTSRLRQMALEGTEVEGCVSCML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTF1</accession>
    <name>A0A7U8TTF1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RCK C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899982.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTF1"/>
    <dbReference type="GeneID" id="45427229"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026278">
        <property type="entry name" value="K(+)/H(+)_antiporter_KhtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005028">
        <property type="entry name" value="KhtT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK C-terminal" evidence="1">
        <location>
            <begin position="75"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="160" mass="17234" checksum="C30D11F8EAB11865" modified="2021-06-02" version="1">MDVKEVLLPGVGLRYEFTSYRGDRIGIVARRSGGFDVVLYGRDDPDEARPVLRLTDEEAEAVAQILGAPRIAERFTELTREVPGLKAGQIHIRAGSLFVDRPLGDTRARTRTGASIVAIVRDEDVLASPGPTDVLRAGDVLIVIGTEDGIAGVEQIVEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTG8</accession>
    <name>A0A7U8TTG8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030978162" evidence="1">
        <location>
            <begin position="28"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="379" mass="43106" checksum="6341209B6D91F229" modified="2021-06-02" version="1">MHRRTALKLPLLLAAGTVLGQAPRAAAGEPGRWSADRAHRWYQAHGWLVGANYITSNAINQLEMFQPGTYDPRRIDNELGLARFHGFNTVRVFLHDLLWAQDAPGFQTRLAQFVAIAARYHIKPLFVLFDSCWDPLPRPGRQRAPRAGVHNSGWVQSPGAERLDDRRYASTLYNYVTGVLGQFRNDDRVLGWDLWNEPDNPARVYRKVERKDKLERVAELLPQVFRWARTVDPVQPLTSGVWQGNWGDPGRRSTISAIQLDNADVITFHSYASPAEFEGRIAELAPLQRPILCTEYLARSQGSTVEGILPIAKRHNVGAFNWGLVAGKTQTYLPWDSWDHPYRAPPKVWFHDLLHPNGRPYRDGEVQTIRKLNGMPSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTH5</accession>
    <name>A0A7U8TTH5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bifunctional F420 biosynthesis protein FbiB</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Coenzyme F420:L-glutamate ligase</fullName>
                <ecNumber evidence="10">6.3.2.31</ecNumber>
                <ecNumber evidence="10">6.3.2.34</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Coenzyme F420-0:L-glutamate ligase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Coenzyme F420-1:gamma-L-glutamate ligase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Dehydro-coenzyme F420-0 reductase</fullName>
                <ecNumber evidence="10">1.3.8.17</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">fbiB</name>
        <name evidence="13" type="ORF">TBLG_03900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2-dependent reduction of dehydro-F420-0 to form F420-0.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>FMN + H(+) + oxidized coenzyme F420-0 = dehydro coenzyme F420-0 + FMNH2</text>
            <dbReference type="Rhea" id="RHEA:60360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:143705"/>
            <dbReference type="EC" id="1.3.8.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + L-glutamate + oxidized coenzyme F420-(gamma-L-Glu)(n) = GDP + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n+1) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:51236"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:12940"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + L-glutamate + oxidized coenzyme F420-0 = GDP + H(+) + oxidized coenzyme F420-1 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30555"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59907"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + L-glutamate + oxidized coenzyme F420-1 = GDP + H(+) + oxidized coenzyme F420-2 + phosphate</text>
            <dbReference type="Rhea" id="RHEA:30523"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57922"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:59920"/>
            <dbReference type="EC" id="6.3.2.34"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Monovalent cation. The ion could be potassium.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. The ions could be magnesium and/or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the N-terminal section; belongs to the CofE family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.31" evidence="10"/>
    <dbReference type="EC" id="6.3.2.34" evidence="10"/>
    <dbReference type="EC" id="1.3.8.17" evidence="10"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900663.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTH5"/>
    <dbReference type="GeneID" id="45427256"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052618">
        <property type="term" value="F:coenzyme F420-0:L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052619">
        <property type="term" value="F:coenzyme F420-1:gamma-L-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052890">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052645">
        <property type="term" value="P:F420-0 metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01259">
        <property type="entry name" value="F420_ligase_FbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008225">
        <property type="entry name" value="F420-0_g-glutamyl_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002847">
        <property type="entry name" value="F420-0_gamma-glut_ligase-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019943">
        <property type="entry name" value="F420_FbiB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023661">
        <property type="entry name" value="FbiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01996">
        <property type="entry name" value="F420_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01916">
        <property type="entry name" value="F420_cofE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03553">
        <property type="entry name" value="F420_FbiB_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_ligase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="11">
        <location>
            <begin position="260"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme F420:L-glutamate ligase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Dehydro-coenzyme F420-0 reductase" evidence="10">
        <location>
            <begin position="245"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="20"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="260"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>coenzyme F420-(gamma-Glu)n</name>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD15002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="448" mass="47578" checksum="8C6DB75DE6E86851" modified="2021-06-02" version="1">MTGPEHGSASTIEILPVIGLPEFRPGDDLSAAVAAAAPWLRDGDVVVVTSKVVSKCEGRLVPAPEDPEQRDRLRRKLIEDEAVRVLARKDRTLITENRLGLVQAAAGVDGSNVGRSELALLPVDPDASAATLRAGLRERLGVTVAVVITDTMGRAWRNGQTDAAVGAAGLAVLRNYAGVRDPYGNELVVTEVAVADEIAAAADLVKGKLTATPVAVVRGFGVSDDGSTARQLLRPGANDLFWLGTAEALELGRQQAQLLRRSVRRFSTDPVPGDLVEAAVAEALTAPAPHHTRPTRFVWLQTPAIRARLLDRMKDKWRSDLTSDGLPADAIERRVARGQILYDAPEVVIPMLVPDGAHSYPDAARTDAEHTMFTVAVGAAVQALLVALAVRGLGSCWIGSTIFAADLVRDELDLPVDWEPLGAIAIGYADEPSGLRDPVPAADLLILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TUB6</accession>
    <name>A0A7U8TUB6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018929">
        <property type="entry name" value="DUF2510"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10708">
        <property type="entry name" value="DUF2510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2510" evidence="3">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="260" mass="28501" checksum="AABDC9B19FFF6D58" modified="2021-06-02" version="1">MEHDVATSPPAGWYTDPDGSAGQRYWDGDRWTRHRRPNPSAPRSPLALRVDGLRSRWLGMPAGLRLTVPVAAVLTMVGVAVYAWIRPLPDDWSQLPKRLSCQLRPGPTPPATITVASVDVSHPRGAVLRLVVRFAEPLPPSPSGSFASGFAGYLLTYTIANNGKEFAELGPQQDTDELAIRKPGESRGTEPNMRPDRNTNARRTAPDTVEINLETKRLGLDQAPVDPQLTFAAQFRTPSTVTVDFGSQFCQGERLAGQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2D0</accession>
    <name>A0A7U8Y2D0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02752</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403213.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2D0"/>
    <dbReference type="GeneID" id="45424578"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="75" mass="8195" checksum="4AC8F2ADE7D65C9A" modified="2021-06-02" version="1">MRTTIDLPQDLHKQALAIARDTHRTLSETVADLMRRGLAANRPTALSSDPRTGLPLVSVGTVVTSEDVRSLEDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2D2</accession>
    <name>A0A7U8Y2D2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RecBCD enzyme subunit RecC</fullName>
            <ecNumber evidence="6">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exonuclease V subunit RecC</fullName>
            <shortName evidence="6">ExoV subunit RecC</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Helicase/nuclease RecBCD subunit RecC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">recC</name>
        <name evidence="8" type="ORF">TBLG_02766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RecC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="6"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2D2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009338">
        <property type="term" value="C:exodeoxyribonuclease V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01486">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006697">
        <property type="entry name" value="RecC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041500">
        <property type="entry name" value="RecC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17946">
        <property type="entry name" value="RecC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000980">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01450">
        <property type="entry name" value="recC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecC_C" evidence="7">
        <location>
            <begin position="795"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1097" mass="119501" checksum="D23908283F18D580" modified="2021-06-02" version="1">MALHLHRAERTDLLADGLGALLADPQPDPFAQELVLVAARGVERWLSQRLSLVLGCGPGRADGVCAGIAFRNPQSLIAEITGTLDDDPWSPEALAWPLLAVIDASLDEPWCRTLASHLGHFATTDAEAELRRGRRYSVARRLAGLFASYARQRPGLLAAWLDGDLGELPGDLAWQPPLWRALVTTVGADPPHVRHDKTIARLRDGPADLPARLSLFGHTRLACTDVQLLDALAVHHDLHLWLPHPSDELWRALAGFQGADGLLPRRQDTSRRAAQHPLLETLGRDVRELQRALPAARATDEFLGATTKPDTLLGWLQADIAGNAPRPAGRSLSDADRSVQVHACHGPARQIDVLREVLLGLLEDDPTLQPRDIVVMCPDIDTYAPLIVAGFGLGEVAGDCHPAHRLRVRLADRALTQTNPLLSVAAELLTIAETRATASQLLNLAQAAPVRAKFGFADDDLDTITTWVRESNIRWGFDPTHRRRYGLDTVVHNTWRFGLDRILTGVAMSEDSQAWLDTALPLDDVGSNRVELAGRLAEFVERLHHVVGGLSGARPLVAWLDALATGIDLLTACNDGWQRAQVQREFADVLARAGSRAAPLLRLPDVRALLDAQLAGRPTRANFRTGTLTVCTMVPMRSVPHRVVCLVGLDDGVFPRLSHPDGDDVLAREPMTGERDIRSEDRQLLLDAIGAATQTLVITYTGADERTGQPRPPAVPLAELLDALDQTTSAPVRERILVTHPLQPFDRKNVTPGALLGAKPFTFDPAALAAAQAAAGKRCPPTAFISGRLPAPPAADVTLADLLDFFKDPVKGFFRALDYTLPWDVDTVEDSIPVQVDALAEWTVGERMLRDMLRGLHPDDAAHSEWRRGTLPPGRLGVRRAKEIRNRARDLAAAALAHRDGHGQAHDVDVDLGDGRRLSGTVTPVFGGRTVSVTYSKLAPKHVLPAWIGLVTLAAQEPGREWSALCIGRSKTRNHIARRLFVPPPDPVAVLRELVLLYDAGRREPLPLPLKTSCAWAQARRDGQDPYPPARECWQTNRFRPGDDDAPAHVRAWGPRAPFEVLLGKPRAGEEVAGEETRLGALAARLWLPLLAAEGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2F7</accession>
    <name>A0A7U8Y2F7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpsG</name>
        <name evidence="10" type="ORF">TBLG_02826</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403456.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2F7"/>
    <dbReference type="GeneID" id="45424645"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="9">
        <location>
            <begin position="1"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="156" mass="17600" checksum="D308045C78F01166" modified="2021-06-02" version="1">MPRKGPAPKRPLVNDPVYGSQLVTQLVNKVLLKGKKSLAERIVYGALEQARDKTGTDPVITLKRALDNVKPALEVRSRRVGGATYQVPVEVRPDRSTTLALRWLVGYSRQRREKTMIERLANEILDASNGLGASVKRREDTHKMAEANRAFAHYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2P9</accession>
    <name>A0A7U8Y2P9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403827.1">
        <property type="nucleotide sequence ID" value="NZ_KK338667.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2P9"/>
    <dbReference type="GeneID" id="45424709"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010093">
        <property type="entry name" value="SinI_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01764">
        <property type="entry name" value="excise"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="168" mass="19428" checksum="6585892B0E9B9233" modified="2021-06-02" version="1">METLLKTSEAAQILGVSRQHVVNMCDRGEMVCVHVGSHRRVPSSEVERVTSRRLTREEERSLWLHRALLSPLLTEPDTVVSAARENLRRWSGMHRRDGMAGWYFTKWQRVLNDGLDAVMHVLTSPSEDAREMRQNSPFAGILPEATRVAVLRSFKDHWDREHERAMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2R4</accession>
    <name>A0A7U8Y2R4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="3">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="457" mass="48627" checksum="25D931E8A65BC50D" modified="2021-06-02" version="1">MTEPWIAFPPEVHSAMLNYGAGVGPMLISATQNGELSAQYAEAASEVEELLGVVASEGWQGQAAEAFVAAYMPFLAWLIQASADCVEMAAQQHVVIEAYTAAVELMPTQVELAANQIKLAVLVATNFFGINTIPIAINEAEYVEMWVRAATTMATYSTVSRSALSAMPHTSPPPLILKSDELLPDTGEDSDEDGHNHGGHSHGGHARMIDNFFAEILRGVSAGRIVWDPVNGTLNGLDYDDYVYPGHAIWWLARGLEFFQDGEQFGELLFTNPTGAFQFLLYVVVVDLPTHIAQIATWLGQYPQLLSAALTGVIAHLGAITGLAGLSGLSAIPSAAIPAVVPGADTRRGRAAYVGGRRGGPCSRRAGHAPRLSTRTGGSGRRHRSRPDAAGDWFRRLPALPGRRWRPRNRVRLGTVGPRQGRGVRFRCSRVGGPGLGACAGACCTAGPLGGEGTWPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2T9</accession>
    <name>A0A7U8Y2T9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404627.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424849"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025859">
        <property type="entry name" value="AurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11583">
        <property type="entry name" value="AurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="340" mass="39798" checksum="F36E94080DE8A605" modified="2021-06-02" version="1">MDRTRIVRRWRRNMDVADDAEYVEMLATLSEGSVRRNFNPYTDIDWESPEFAVTDNDPRWILPATDPLGRHPWYQAQSRERQIEIGMWRQANVAKVGLHFESILIRGLMNYTFWMPNGSPEYRYCLHESVEECNHTMMFQEMVNRVGADVPGLPRRLRWVSPLVPLVAGPLPVAFFIGVLAGEEPIDHTQKNVLREGKSLHPIMERVMSIHVAEEARHISFAHEYLRKRLPRLTRMQRFWISLYFPLTMRSLCNAIVVPPKAFWEEFDIPREVKKELFFGSPESRKWLCDMFADARMLAHDTGLMNPIARLVWRLCKIDGKPSRYRSEPQRQHLAAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2U4</accession>
    <name>A0A7U8Y2U4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405145.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2U4"/>
    <dbReference type="GeneID" id="45424962"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="306" mass="32406" checksum="880D3BB88CB0A3EA" modified="2021-06-02" version="1">MSRPEVLTPFTAIVPAAGLGTRFLPATKTVPKELLPVVDTPGIELVAAEAAAAGAERLVIVTSEGKDGVVAHFVEDLVLEGTLEARGKIAMLAKVRRAPALIKVESVVQAEPLGLGHAIGCVEPTLSPDEDAVAVLLPDDLVLPTGVLETMSKVRASRGGTVLCAIEVAREEISAYGVFDVEPVPDGDYTDDPNVLKVRGMVEKPKAETAPSRYAAAGRYVLDRAIFDALRRIDRGAGGEVQLTDAIALLIAEGHPVHVVVHQGSRHDLGNPGGYLKAAVDFALDRDDYGPDLRRWLVARLGLTEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2X3</accession>
    <name>A0A7U8Y2X3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS faily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031355334" evidence="1">
        <location>
            <begin position="34"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="139" mass="13783" checksum="3C1DB570F6CDA1FB" modified="2021-06-02" version="1" fragment="single">MSFVNVAPQLVSTAAADAARIGSAINTANTAAAATTQVLAAAQDEVSTAIAALFGSHGQHYQAISAQVAAYQERFVLALSQASSTYAVAEAASATPLQNVLDAINAPVQSLTGRPLIGDGANGIDGTGQAGGNGGWLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Y4</accession>
    <name>A0A7U8Y2Y4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405982.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425119"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="216" mass="23405" checksum="193B44A47DD8A113" modified="2021-06-02" version="1">MTSGAAASASRVDHPLFARIWPVVAAHEAEAIRALRRENLAGLSGRVLEVGAGVGTNFAYYPVAVEQVIAMEPEPRLAAKARIAAADAPVPIVVTDKTVEEFRDTETFDAVVCSLVLCSVSDPGAVLAHLRSLLRRGGELRYLEHVASAGARGRVQRFVDATFWPRLAGNCHTHRHTERAILDAGFVVDSSRREWAFPAWVPLPVSELALGRAHRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y316</accession>
    <name>A0A7U8Y316_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03441</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y316"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01277">
        <property type="entry name" value="HINT_subgroup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039384">
        <property type="entry name" value="HINT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="PTHR46648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="96"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="144" mass="15740" checksum="ACC8386CB8E99CC1" modified="2021-06-02" version="1">MPCVFCAIIAGEAPAIRIYEDGGYLAILDIRPFTRGHTLVLPKRHTVDLTDTPPEALADMVAIGQRIARAARATKLADATHIAINDGRAAFQTVFHVHLHVLPRRNGDKLSVAKGMMLRRDPDREATGRILREALAQQDAAAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y453</accession>
    <name>A0A7U8Y453_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Elongation factor G</fullName>
            <shortName evidence="6">EF-G</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fusA</name>
        <name evidence="8" type="ORF">TBLG_02827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898554.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y453"/>
    <dbReference type="GeneID" id="45424646"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="11"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="84"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="701" mass="77203" checksum="0C6DD4C128E31EA1" modified="2021-06-02" version="1">MAQKDVLTDLSRVRNFGIMAHIDAGKTTTTERILYYTGINYKIGEVHDGAATMDWMEQEQERGITITSAATTTFWKDNQLNIIDTPGHVDFTVEVERNLRVLDGAVAVFDGKEGVEPQSEQVWRQADKYDVPRICFVNKMDKIGADFYFSVRTMGERLGANAVPIQLPVGAEADFEGVVDLVEMNAKVWRGETKLGETYDTVEIPADLAEQAEEYRTKLLEVVAESDEHLLEKYLGGEELTVDEIKGAIRKLTIASEIYPVLCGSAFKNKGVQPMLDAVVDYLPSPLDVPPAIGHAPAKEDEEVVRKATTDEPFAALAFKIATHPFFGKLTYIRVYSGTVESGSQVINATKGKKERLGKLFQMHSNKENPVDRASAGHIYAVIGLKDTTTGDTLSDPNQQIVLESMTFPDPVIEVAIEPKTKSDQEKLSLSIQKLAEEDPTFKVHLDSETGQTVIGGMGELHLDILVDRMRREFKVEANVGKPQVAYKETIKRLVQNVEYTHKKQTGGSGQFAKVIINLEPFTGEEGATYEFESKVTGGRIPREYIPSVDAGAQDAMQYGVLAGYPLVNLKVTLLDGAYHEVDSSEMAFKIAGSQVLKKAAALAQPVILEPIMAVEVTTPEDYMGDVIGDLNSRRGQIQAMEERAGARVVRAHVPLSEMFGYVGDLRSKTQGRANYSMVFDSYSEVPANVSKEIIAKATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y487</accession>
    <name>A0A7U8Y487_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty-acid-CoA ligase fadD8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02679</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="59"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="470"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="571" mass="61066" checksum="3E4AD9522238C294" modified="2021-06-02" version="1">MSTAGDDAVGVPPACGGRSDAVGVPQLARESGAMRDQDCSGELLRSPTHNGHLLVGALKRHQNKPVLFLGDTRLTGGQLADRISQYIQAFEALGAGTGVAVGLLSLNRPEVLMIIGAGQARGYRRTALHPLGSLADHAYVLNDAGISSLIIDPNPMFVERALALLEQVDSLQQILTIGPVPDALKHVAVDLSAEAAKYQPQPLVAADLPPDQVIGLTYTGGTTGKPKGVIGTAQSIATMTSIQLAEWEWPANPRFLMCTPLSHAGAAFFTPTVIKGGEMIVLAKFDPAEVLRIIEEQRITATMLVPSMLYALLDHPDSHTRDLSSLETVYYGASAINPVRIAEAIRRFGPIFAQYYGQSEAPMVITYLAKGDHDEKRLTSCGRPTLFARVALLDEHGKPVKQGEVGEICVSGPLLAGGYWNLPDETSRTFKDGWLHTGDLAREDSDGFYYIVDRVKDMIVTGGFNVFPREVEDVVAEHPAVAQVCVVGAPDEKWGEAVTAVVVLRSNAARDEPAIEAMTAEIQAAVKQRKGSVQAPKRVVVVDSLPLTGLGKPDKKAVRARFWEGAGRAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y488</accession>
    <name>A0A7U8Y488_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD_binding_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y488"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033765">
        <property type="term" value="F:steroid dehydrogenase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014614">
        <property type="entry name" value="UCP036654"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43260">
        <property type="entry name" value="PTHR43260"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036654">
        <property type="entry name" value="UCP036654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="23"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="566" mass="61296" checksum="005B476B84ECE128" modified="2021-06-02" version="1">MALTCTDMSDAVAGSDAEGLTADAIVVGAGLAGLVAACELADRGLRVLILDQENRANVGGQAFWSFGGLFLVNSPEQRRLGIRDSHELALQDWLGTAAFDRPEDYWPEQWAHAYVDFAAGEKRSWLRARGLKIFPLVGWAERGGYDAQGHGNSVPRFHITWGTGPALVDIFVRQLRDRPTVRFAHRHQVDKLIVEGNAVTGVRGTVLEPSDEPRGAPSSRKSVGKFEFRASAVIVASGGIGGNHELVRKNWPRRMGRIPKQLLSGVPAHVDGRMIGIAQKAGAAVINPDRMWHYTEGITNYDPIWPRHGIRIIPGPSSLWLDAAGKRLPVPLFPGFDTLGTLEYITKSGHDYTWFVLNAKIIEKEFALSGQEQNPDLTGRRLGQLLRSRAHAGPPGPVQAFIDRGVDFVHANSLRELVAAMNELPDVVPLDYETVAAAVTARDREVVNKYSKDGQITAIRAARRYRGDRFGRVVAPHRLTDPKAGPLIAVKLHILTRKTLGGIETDLDARVLKADGTPLAGLYAAGEVAGFGGGGVHGYRALEGTFLGGCIFSGRAAGRGAAEDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y498</accession>
    <name>A0A7U8Y498_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin thiX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="34"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="140" mass="14774" checksum="307824A6F5F18356" modified="2021-06-02" version="1">MTTMIVSSVATGALATIARWLLTRRSVILREVGPETTPAAPARTAELGLSGAGPTVVHFRAPGCAPCDRVRRGVGDVCADLGDVAHIEVDLDSNPQAARRFSVLSLPTTLIFDVDGRQRYRTSGVPKAADLRSALKPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4B3</accession>
    <name>A0A7U8Y4B3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty-acid-CoA racemase far</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404414.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4B3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="359" mass="38059" checksum="20F09F5298A5D49B" modified="2021-06-02" version="1">MTTGGPLAGVKVIELGGIGPGPHAGMVLADLGADVVRVRRPGGLTMPSEDRDLLHRGKRIVDLDVKTQPQAMLELAAKADVLLDCFRPGTCERLGIGPDDCASVNPRLIFARITGWGQDGPLASTAGHDINYLSQTGALAAFGYADRPPMPPLNLVADFGGGSMLVLLGIVVALYERERSGVGQVVDAAMVDGVSVLAQMMWTMKGIGSLRDQRESFLLDGGAPFYRCYETSDGKYMAVGAIEPQFFAALLSGLGLSAADVPTQLDVAGYPQMYDIFAERFASRTRDEWTRVFAGTDACVTPVLAWSEAANNDHLKARSTVITAHGVQQAAPAPRFSRTPAGPVRPPPAAATPIDEINW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4E4</accession>
    <name>A0A7U8Y4E4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bifunctional 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase/cyclase/dehydrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03097</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404801.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4E4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="355"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="644" mass="69354" checksum="7DBEB7535F00819C" modified="2021-06-02" version="1">MKWVTYRSDHGERTGVLSGDAIYAMPPDVSLLDLVGRGADGLRTAGERAVRSPAAVVALDEVTLAAPIPRPPSIRDSLCFLDHMRNCQEAMGGGRVLMDTWYRIPAFYFACPSTVLGPYDDAPTAPGSAWQDFELEIAAVIGTSGKDLTVEQAERSIIGYTIFNDWSARDLQMLEGQLRIGQAKGKDSGITLGPYLVTPDELEPYCRGGKLSLRVIALVNGTVIGSGSTAQMDWSFGEVIAYASRGVTLTPGDVFGSGTVPTCTLVEHLRPPESFPGWLHDGDVVTLQVEGLGETRQTVRTSGTPFPLALRPNPDAEPDRRGVNPAPTRVPFTRGLHEVADRVWAWTLPDGGYGFSNAGLVAGDGASLLVDTLFDLALTREMLAAMKPVTERAPITDALITHSNGDHTHGTQLLDRSVRIIAAKGTSEEIEHGPAPEMLARIQTADLGPVATRYLRDRFGHFDFSGIKLRNADLTFDRDLAIELGGRRVDLLNLGPAHTTADSVVHVADAGVLFAGDLLFIGCTPIVWAGPIANWVAACDAMIALDAPTVVPGHGPVTGPDGIRAVRGYLAHIAEQAEAAYRKGLSLPEAVETIDLGEYASWLDSERVVVNVYQRYRELDPDTPRQDLLALLVMQAEWAARHCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4I9</accession>
    <name>A0A7U8Y4I9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405640.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4I9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="7"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="46"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="285" mass="29279" checksum="81F63797E3A927C5" modified="2021-06-02" version="1">MTTRRALVLAGGGLAGIAWETGVLRGIADESPAAARLLLDSDVLVGTSAGATVAAQISSGCPLDTLYERQLAETSAEIDPGVDIDAITDLFLTAVTEPHISTRRRLQRIGAVALAVDTVPESVRRQVIAQRLPSHDWPDRVLRVTAIDIATGELVVFHRESNVALVDAVAASCSVPGAWPPVTIAGRRYMDGGVASSVNLGVADDCDAAVVLVPAGADAPSPFGGGAAAEIAAATGMVFAVFADDDSLAAFGPNPLDPLCRVNSAMAGRQQGRREAQAVARLLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4S7</accession>
    <name>A0A7U8Y4S7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cystathionine gamma-synthase metB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03249</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405736.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4S7"/>
    <dbReference type="GeneID" id="45425051"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="388" mass="40982" checksum="B6D9C0F78F3EAE71" modified="2021-06-02" version="1">MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFARAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPLLSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAGAVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRAAQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4T9</accession>
    <name>A0A7U8Y4T9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">zwf</name>
        <name evidence="9" type="ORF">TBLG_03294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898735.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4T9"/>
    <dbReference type="GeneID" id="45425094"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="13"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="184"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="466" mass="52173" checksum="536302013052A596" modified="2021-06-02" version="1">MVDGGGGASDLLVIFGITGDLARKMTFRALYRLERHQLLDCPILGVASDDMSVGQLVKWARESIGRTEKIDDAVFDRLAGRLSYLHGDVTDSQLYDSLAELIGSACRPLYYLEMPPALFAPIVENLANVRLLERARVAVEKPFGHDLASALELNARLRAVLGEDQILRVDHFLGKQPVVELEYLRFANQALAELWDRNSISEIHITMAEDFGVEDRGKFYDAVGALRDVVQNHLLQVLALVTMEPPVGSSADDLNDKKAEVFRAMAPLDPDRCVRGQYLGYTEVAGVASDSATETYVALRTEIDNWRWAGVPIFVRAGKELPAKVTEVRLFLRRVPALAFLPNRRPAEPNQIVLRIDPDPGMRLQISAHTDDSWRDIHLDSSFAVDLGEPIRPYERLLYAGLVGDHQLFAREDSIEQTWRIVQPLLDNPGEIHRYDRGSWGPEAAQSLLRGHRGWQSPWLPRGTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4W2</accession>
    <name>A0A7U8Y4W2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407345.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4W2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="SSF50370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031292981" description="Ricin B-type lectin domain-containing protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B-type lectin" evidence="2">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD13023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="157" mass="16853" checksum="35CB2E952788773D" modified="2021-06-02" version="1">MGELRLVGGVLRVLVVVGAVFDVAVLNAGAASADGPVQLKSRLGDVCLDAPSGSWFSPLVINPCNGTDFQRWNLTDDRQVESVAFPGECVNIGNALWARLQPCVNWISQHWTVQPDGLVKSDLDACLTVLGGPDPGTWVSTRWCDPNAPDQQWDSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4Z2</accession>
    <name>A0A7U8Y4Z2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="9">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">argS</name>
        <name evidence="13" type="ORF">TBLG_03474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="9"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4Z2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arg_tRNA_synt_N" evidence="12">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DALR_1" evidence="11">
        <location>
            <begin position="429"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="550" mass="59709" checksum="4F11239A6238124D" modified="2021-06-02" version="1">MTPADLAELLKATAAAVLAERGLDASALPQMVTVERPRIPEHGDYASNLAMQLAKKVGTNPRELAGWLAEALTKVDGIASAEVAGPGFINMRLETAAQAKVVTSVIDAGHSYGHSLLLAGRKVNLEFVSANPTGPIHIGGTRWAAVGDALGRLLTTQGADVVREYYFNDHGAQIDRFANSLIAAAKGEPTPQDGYAGSYITNIAEQVLQKAPDALSLPDAELRETFRAIGVDLMFDHIKQSLHEFGTDFDVYTHEDSMHTGGRVENAIARLRETGNIYEKDGATWLRTSAFGDDKDRVVIKSDGKPAYIAGDLAYYLDKRQRGFDLCIYMLGADHHGYIARLKAAAAAFGDDPATVEVLIGQMVNLVRDGQPVRMSKRAGTVLTLDDLVEAIGVDAARYSLIRSSVDTAIDIDLALWSSASNENPVYYVQYAHARLSALARNAAELALIPDTNHLELLNHDKEGTLLRTLGEFPRVLETAASLREPHRVCRYLEDLAGDYHRFYDSCRVLPQGDEQPTDLHTARLALCQATRQVIANGLAIIGVTAPERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y502</accession>
    <name>A0A7U8Y502_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898821.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y502"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="4">
        <location>
            <begin position="361"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="567" mass="61935" checksum="0D6D7C290C49C349" modified="2021-06-02" version="1">MPSEKATTRHLPGAVETLSPRTGRRPETPAYGSWLLGRVSESPRMRRVRIQGMLTVAILVTNVIGLIVGAMLLTVAFPKPSVILDAPHWVSFGIVPGYCVLAFILGTYWLTRQTARALRWAIEERTPSHDEARSAFLVPLRVALAVLFLWGAAAALWTIIYGLANRLFIPRFLFSMGVIGVVAATSCYLLTEFALRPMAAQALEVGATPRSLVRGIVGRTMLVWLLCSGVPNVGVALTAIFDDTFWELSNDQFMITVLILWAPLLIFGFILMWILAWLTATPVRVVREALNRVEQGDLSGDLVVFDGTELGELQRGFNRMVEGLRERERVRDLFGRHVGREVAAAAERERPKLGGEERHVAVVFVDIVGSTQLVTSRPAAEVVMLLNRFFTVIVDEVNHHRGLVNKFQGDASLAVFGAPNRLSHPEDAALATARAIADRLASEMPECQAGIGVAAGQVVAGNVGAHERFEYTVIGEPVNEAARLCELAKSYPSRLLASSQTLRGASENECARWSLGETVTLRGHDQPIRLASPVQQLQMPAQSADIVGGALGDHQTHTIYRGAHPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7D1</accession>
    <name>A0A7U8Y7D1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899902.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7D1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05801">
        <property type="entry name" value="PGM_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005852">
        <property type="entry name" value="PGM_a-D-Glc-sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PTHR22573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01132">
        <property type="entry name" value="pgm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="10">
        <location>
            <begin position="40"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="11">
        <location>
            <begin position="209"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="12">
        <location>
            <begin position="323"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="9">
        <location>
            <begin position="490"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD14790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="547" mass="58266" checksum="1825BDDE89A9E951" modified="2021-06-02" version="1">MVANPRAGQPAQPEDLVDLPHLVTAYYSIEPDPDDLAQQVAFGTSGHRGSALTGTFNELHILAITQAIVEYRAAQGTTGPLFIGRDTHGLSEPAWVSALEVLAANQVVAVVDSRDRYTPTPAISHAILTYNRGRTEALADGIVVTPSHNPPSDGGIKYNPPNGGPADTAATTAIAKRANEILLARSMVKRLPLARALRTAQRHDYLGHYVDDLPNVVDIAAIREAGVRIGADPLGGASVDYWGEIAHRHGLDLTVVNPLVDATWRFMTLDTDGKIRMDCSSPDAMAGLIRTMFGNRERYQIATGNDADADRHGIVTPDEGLLNPNHYLAVAIEYLYTHRPSWPAGIAVGKTVVSSSIIDRVVAGIGRQLVEVPVGFKWFVDGLIGATLGFGGEESAGASFLRRDGSVWTTDKDGIIMALLAAEILAVTGATPSQRYHALAGEYGGPCYARIDAPADREQKARLARLSADQVSATELAGEPITAKLTTAPGNGAALGGLKVTTANAWFAARPSGTEDVYKIYAESFRGPQHLVEVQQTAREVVDRVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7X1</accession>
    <name>A0A7U8Y7X1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, tetR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416573.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7X1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="213" mass="23121" checksum="7E2B1CC982D79033" modified="2021-06-02" version="1">MPRQAGRWSPTALRILGAAAELIALRGYSSTSTRDIAAAVGVEQPAIYKHFSAKRDILAALVRLAVEWPLELFGHITAMPVPAVVKLHRWLTESLDHLHASPYVLVSILITPDLHQESFVAERELVAEMERALVGLIETGQGEGDVRAMHPLSAARLVQALFDALALPEFAVSPDEIVEFAMTALLSDPDRLAEIRAAADALEIQTAPPDRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Z9</accession>
    <name>A0A7U8Y7Z9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="11">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">secA</name>
        <name evidence="18" type="ORF">TBLG_03873</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="11">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11 12">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="11"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020937">
        <property type="entry name" value="SecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01312">
        <property type="entry name" value="SECA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 11 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 11 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="17">
        <location>
            <begin position="15"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="104"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="432"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="882"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="746"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="937"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFD14975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="962" mass="107273" checksum="E20DAE7DF1301EAF" modified="2021-06-02" version="1">MGVALSKDSYTCGDIAVLSKLLRLGEGRMVKRLKKVADYVGTLSDDVEKLTDAELRAKTDEFKRRLADQKNPETLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGAAALHLGNVAEMKTGEGKTLTCVLPAYLNALAGNGVHIVTVNDYLAKRDSEWMGRVHRFLGLQVGVILATMTPDERRVAYTRHHYAHTSLGRLPARHMAHSLDDLVQRGHHYAIVDEVDSILIDEARTPLIISGPADGASNWYTEFARLAPLMEKDVHYEVDLRKRTVGVHEKGVEFVEDQLGIDNLYEAANSPLVSYLNNALKAKELFSRDKDYIVRDGEVLIVDEFTGRVLIGRRYNEGMHQAIEAKEHVEIKAENQTLATITLQNYFRLYDKLAGMTGTAQTEAAELHEIYKLGVVSIPTNMPMIREDQSDLIYKTEEAKYIAVVDDVAERYAKGQPVLIGTTSVERSEYLSRQFTKRRIPHNVLNAKYHEQEATIIAVAGRRGGVTVATNMAGRGTDIVLGGNVDFLTDQRLRERGLDPVETPEEYEAAWHSELPIVKEEASKEAKEVIEAGGLYVLGTERHESRRIDNQLRGRSGRQGDPGESRFYLSLGDELMRRFNGAALETLLTRLNLPDDVPIEAKMVTRAIKSAQTQVEQQNFEVRKNVLKYDEVMNQQRKVIYAERRRILEGENLKDQALDMVRDVITAYVDGATGEGYAEDWDLDALWTALKTLYPVGITADSLTRKDHEFERDDLTREELLEALLKDAERAYAAREAELEEIAGEGAMRQLERNVLLNVIDRKWREHLYEMDYLKEGIGLRAMAQRDPLVEYQREGYDMFMAMLDGMKEESVGFLFNVTVEAVPAPPVAPAAEPAELAEFAAAAAAAAQQRSAVDGGARERAPSALRAKGVASESPALTYSGPAEDGSAQVQRNGGGAHKTPAGVPAGASRRERREAARRQGRGAKPPKSVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y811</accession>
    <name>A0A7U8Y811_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="255" mass="24622" checksum="0F5ACD83304CD089" modified="2021-06-02" version="1">MVGIGALNSGIGNLGFGNSGNNNIGFFNSGNNNVGFFNSGNNNFGFGNAGDINTGFGNAGDTNTGFGNAGFFNMGIGNAGNEDMGVGNGGSFNVGVGNAGNQSVGFGNAGTLNVGFANAGSINTGFANSGSINTGGFDSGDRNTGFGSSVDQSVSSSGFGNTGMNSSGFFNTGNVSAGYGNNGDVQSGINNTNSGGFNVGFYNSGAGTVGIANSGLQTTGIANSGTLNTGVANTGDHSSGGFNQGSDQSGFFGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y855</accession>
    <name>A0A7U8Y855_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">N5-carboxyaminoimidazole ribonucleotide synthase</fullName>
            <shortName evidence="3 5">N5-CAIR synthase</shortName>
            <ecNumber evidence="3 5">6.3.4.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 5">5-(carboxyamino)imidazole ribonucleotide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">purK</name>
        <name evidence="9" type="ORF">TBLG_03915</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="function">
        <text evidence="5">Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 5">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ATP + hydrogencarbonate = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19317"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.18" evidence="3 5"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417126.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y855"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00942"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034028">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004638">
        <property type="term" value="F:phosphoribosylaminoimidazole carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01928">
        <property type="entry name" value="PurK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005875">
        <property type="entry name" value="PurK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040686">
        <property type="entry name" value="PurK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17769">
        <property type="entry name" value="PurK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01161">
        <property type="entry name" value="purK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031515430" description="N5-carboxyaminoimidazole ribonucleotide synthase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="121"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="194"/>
            <end position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="280"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="429" mass="45695" checksum="1A80B4CCAB8CB13E" modified="2021-06-02" version="1">MMAVASSRTPAVTSFIAPLVAMVGGGQLARMTHQAAIALGQNLRVLVTSADDPAAQVTPNVVIGSHTDLAALRRVAAGADVLTFDHEHVPNELLEKLVADGVNVAPSPQALVHAQDKLVMRQRLAAAGVAVPRYAGIKDPDEIDVFAARVDAPIVVKAVRGGYDGRGVRMARDVADARDFARECLADGVAVLVEERVDLRRELSALVARSPFGQGAAWPVVQTVQRDGTCVLVIAPAPALPDDLATAAQRLALQLADELGVVGVLAVELFETTDGALLVNELAMRPHNSGHWTIDGARTSQFEQHLRAVLDYPLGDSDAVVPVTVMANVLGAAQPPAMSVDERLHHLFARMPDARVHLYGKAERPGRKVGHINFLGSDVAQLCERAELAAHWLSHGRWTDGWDPHRASDDAVGVPPACGGRSDEEERRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA62</accession>
    <name>A0A7U8YA62_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="553" mass="60643" checksum="9D27F711A7137DF5" modified="2021-06-02" version="1">MQPSHPTRPGAVIRYVGSSLDTCPMTTFAGKTAASADKVRGGYYTPPAVARFLAHWVHQAGPKILEPSCGDGRILRELSAITDHAHGVELVAREAKKSRDFASVDTENLFTWLHKTQLGSWDGVAGNPPYIRFGNRASEQRDPALELMRRVGLRPTKLTNAWVPFVVASTTLARDGGRVGLVVPAELLQVTYAAQLREFLLSRYREITLVTFERLVFDGILQEVVLFCGVVGPGPAHIRTVRLGDANDLNALGDKDFTNESAPALLHEKEKWTKYFLDPAQIRLLRGLKQSATMIRLGELADVDVGIVTGRNSFFTFTDAKAQALGLRAHCVPLVSRSAQLSGLIYDEDCRACDVAGNHRTWLLDAADYPTDPALVAHITAGEAAGVHLGYKCSIRKPWWSTPSLWMPDLFMLRQIHFAPRLTVNAAAATSTDTVHRVRLDPNVDPATLAAVFHNSATFAFAEIMGRSYGGGILELEPREAEQLPMPPPAYGSAELAQDVDLLLKANEIDKALDVVDRHVLIDGLGLSPRLVAGCRAAWLTLRDRRTKRGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA86</accession>
    <name>A0A7U8YA86_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA86"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044003">
        <property type="term" value="P:modulation by symbiont of host process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="PTHR31956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031293171" evidence="2">
        <location>
            <begin position="37"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="299" mass="31777" checksum="C999D8ECF62C9788" modified="2021-06-02" version="1">MLRGIQALSRPLTRVYRALAVIGVLAASLLASWVGAVPQVGLAASALPTFAHVVIVVEENRSQAAIIGNKSAPFINSLAANGAMMAQAFAETHPSEPNYLALFAGNTFGLTKNTCPVNGGALPNLGSELLSAGYTFMGFAEDLPAVGSTVCSAGKYARKHVPWVNFSNVPATLSVPFSAFPKPQNYPGLPTVSFVIPNADNDMHDGSIAQGDAWLNRHLSAYANWAKTNNSLLVVTWDEDDGSSRNQIPTVFYGAHVRPGTYNETISHYNVLSTLEQIYGLPKTGYATNAPPITDIWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAB5</accession>
    <name>A0A7U8YAB5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP/GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417769.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAB5"/>
    <dbReference type="GeneID" id="45427361"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="193" mass="20737" checksum="BE68ABF43C545E62" modified="2021-06-02" version="1">MALKHSEASGTASTKIVIAGGFGSGKTTFVGAVSEIMPLRTEAMVTDASAGVDMLEATPDKRSTTVAMDFGRITLGEDLVLYLFGTPGQRRFWFMWDDLVRGAIGAIVLVDCRRLQDSFAAVDFFEHRNLPFLIAINEFDSAPRYPVSAVRDALTLPAHIPVINVDARNRRSATDALIAVSEYALATLSPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAE6</accession>
    <name>A0A7U8YAE6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Probable DNA-directed RNA polymerase rpoa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA_pol_A_CTD" evidence="3">
        <location>
            <begin position="68"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="173" mass="18717" checksum="99A172583EC0F891" modified="2021-06-02" version="1">PTRWTPPGSSSAPTSTSWILDVETKNSISPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIKLHQLGLSLKDSPPSFDPSEVAGYDVATGTWSTEGAYDEQDYAETEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFA6</accession>
    <name>A0A7U8TFA6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Malonyl CoA-acyl carrier protein transacylase fabD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403326.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="224" mass="23617" checksum="89B882A9D9312A70" modified="2021-06-02" version="1">MSGRSRLPGSSSRRDAARIVAERVVATVAGVAVAVDEVDAAEARLRDGPRAAALPASGTSEGRQLRRWLTQLIVTERVVAAEAAARGLTAAGAPAEADLLPDATARLEIGSVAAAVLADPLARALFAAVTARVAVTDDAVADYHARNPLRFAAPCPGQHGWRAPAAAAPPLDQVRRAITEHLLGAARRRAFRVWLDARRNALVVLAPGYEHPGDPRQPDNTRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFB4</accession>
    <name>A0A7U8TFB4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-mannosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02785</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="SSF88688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-mann_mid" evidence="5">
        <location>
            <begin position="398"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1023"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1023" mass="111674" checksum="97EDA26FA346CA8E" modified="2021-06-02" version="1" fragment="single">MRVVSAESTELFVGPSDAPLQLVRVAVTGCTEPAPIRIHGDGLAGEAAARPGDDVIEVAVAVESPVVGERRTARVHTPDGPSLAFEFTVAEPGWTMFMISHFHYDPVWWNTQGAYTSQWREDPPGRARQANGFELVRAHLEMARREPEYKFVLAEVDYLKPYWDTHPQDRADLRRFLADGRIEVMGGTYNEPNTNLTSPETTIRNLVHGIGFQRDVLGAEPATAWQLDVFGHDPQFPGLAADAGLTSSSWARGPHHQWGPAQGGVDRMQFCSEFEWIAPSGRGLLTHYMPAHYSAGWSMDSSTSLADAEAATYALFDQLKKVALTRNVLLPVGTDYTPPNKWVTAIHRDWGARYTWPRFVCALPKEFFAAVRAELAKRGWVPSPQTRDMNPIYTGKDVSYIDTKQANRAAENAVLEAERFAVFAALLTGAEYPQAALAKAWVQLAYGAHHDAITGSESDQVYLDLLTGWRDAWELGRAARDNSLRLLSGAVAASHDRVVVWNPLTQRRTDIVTARVDPPLQAGVRVFDPDGAEVAALVEHDGRSVTWLACDVPSLGWRVYRLVPADEAPGWELVPGTDIANEHYRLAVDPERGGALSSLVQDGRQLIAAGRVANELALYEEYPSHPTQGEGPWHLLPTGPVVCSSACPAQVQAYRGPLGQRLVVRGRIGTLLRYTQTLTLWDGVDRVDCRTSIDEFTGEDRLLRLRWPCPVPGAMPISEVGDAVVGRGFALLHEGPESVDTAQHPWTLDNPAYGWFGLSSAVRVRAGDGVRAVSVAEVVSPTETVSGPMARDLMVALVRAGVTATCSGADKPRYGHLDVDSNLPDARIALGGPDRNTFTKAVLAEAAPAYTAELQRQLAKTGTARVWVPAANPLARAWLPGADLRAPCALPVLVIDGRDEKHLRAAVASLADDLADAEIVVHQRAAPQMEPFEDRTVALLNRGVPSFAVDSEGTLHTALMRSCTGWPSGVWIDQPRRTAPDGSNFQLQHWTHHFDYALVCGGGDWRRAGIPARSAQFSHPLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFE0</accession>
    <name>A0A7U8TFE0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="49" mass="5362" checksum="FEA3865CA9FC94D7" modified="2021-06-02" version="1">MRQAMRHTRPRVTVAGHGRQTERESAQDRKPVDANHPAAGPQGSSGQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFF2</accession>
    <name>A0A7U8TFF2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403235.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFF2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011660">
        <property type="entry name" value="VapB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07704">
        <property type="entry name" value="PSK_trans_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="84" mass="9140" checksum="E2024613405C6472" modified="2021-06-02" version="1">MALSIKHPEADRLARALAARTGETLTEAVVTALRERLARETGRARVVPLRDELAAIRHRCAALPVVDNRSAEAILGYDERGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFJ8</accession>
    <name>A0A7U8TFJ8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450 51 cyp51</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898577.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFJ8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="451" mass="50878" checksum="B3D671EA9542A57B" modified="2021-06-02" version="1">MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFL0</accession>
    <name>A0A7U8TFL0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, gntR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404007.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFL0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028978">
        <property type="entry name" value="Chorismate_lyase_/UTRA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011663">
        <property type="entry name" value="UTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07702">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00866">
        <property type="entry name" value="UTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64288">
        <property type="entry name" value="SSF64288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="1">
        <location>
            <begin position="20"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="269" mass="28959" checksum="4D49703BC0F29B94" modified="2021-06-02" version="1">MTSVKLDLDAADLRISRGSVPASTQLAEALKAQIIQQRLPRGGRLPSERELIDRSGLSRVTVRAAVGMLQRQGWLVRRQGLGTFVADPVEQELSCGVRTITEVLLSCGVTPQVDVLSHQTGPAPQRISETLGLVEVLCIRRRIRTGDQPLALVTAYLPPGVGPAVEPLLSGSADTETTYAMWERRLGVRIAQATHEIHAAGASPDVADALGLAVGSPVLVVDRTSYTNDGKPLEVVVFHHRPERYQFSVTLPRTLPGSGAGIIEKRDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFN7</accession>
    <name>A0A7U8TFN7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="103" mass="8670" checksum="412F3B9133EB452E" modified="2021-06-02" version="1">MGSPWGGAGGAGGAAPTGNGGAGGNGGDALGLVGVGGNGGNAGTGFGANTGGNGGDTTIVVNGMLAPSTLGYGGNGGNGVNGGAGGTGGKAGVFGAPGQNGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFX0</accession>
    <name>A0A7U8TFX0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="53" mass="5414" checksum="8CC547F9FB3E2A11" modified="2021-06-02" version="1">MVVHIVGLSIETTAPTDSAITPIMVREINIGEIPLGLRLGSDTTLLDAALAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFX4</accession>
    <name>A0A7U8TFX4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03087</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="85"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="324" mass="34292" checksum="16FED577209DE175" modified="2021-06-02" version="1">MVTEPLTKPALVAVDMRPARRGERLFKLAASAAGSTIVIAILLIAIFLLVRAVPSLRANHANFFTSTQFDTSDDEQLAFGVRDLFMVTALSSITALVLAVPVAVGIAVFLTHYAPRRLSRPFGAMVDLLAAVPSIIFGLWGIFVLAPKLEPITRFLNRNLGWLFLFKQGNVSLAGGGTIFTAGIVLSVMILPIVTSISREVFRQTPLIQIEAALALGATKWEVVRMTVLPYGRSGVVAASMLGLGRALGETVAVLVILRSAARPGTWSLFDGGYTFASKIASAASEFSEPLPTGAYISAGFALFVLTFLVNAAARAIAGGKVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFZ0</accession>
    <name>A0A7U8TFZ0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898656.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFZ0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032371">
        <property type="entry name" value="DUF4873"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16170">
        <property type="entry name" value="DUF4873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4873" evidence="2">
        <location>
            <begin position="250"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="346" mass="37206" checksum="F51A5815B5A36136" modified="2021-06-02" version="1">MAGVSEAERRGHRKLVRFQARRAIGPIRPTSAAWDRDFDPAGKRIAVVGTDAAAAHYISRLSESAASVTVFTQAPRRVVTGVPLWTTRAKRWLRRRTGAEHPAVAWATAAIDALTSSGIRTSDGVEHPVDAIIYGTGFAIADQVGDQTLVGAGGVTIRQAWDDGMEPYLGVAVHGFPNYFFITGPDTAAQARCVVECMKLMERTASRRIEVRRSSQQVFNERAQLKPAQPHRQTGGLEAFDLSSAATEDDQTYDGAATLTLAGARFRVRVRLTGHLDPIDGNYHWQGTVFDSLPETSLTHARAATLTIGGRSAPARITEQTPWGTHSVAGVGPPPYARSGPASATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG10</accession>
    <name>A0A7U8TG10_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898666.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033458">
        <property type="entry name" value="DUF5134"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17197">
        <property type="entry name" value="DUF5134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="210" mass="22887" checksum="D4ED4FF6CC098F24" modified="2021-06-02" version="1">MIHDLMLRWVVTGLFVLTAAECGLAIIAKRRPWTLIVNHGLHFAMAVAMAVMAWPWGARVPTTGPAVFFLLAAVWFGATAVVAVRGTATRGLYGYHGLMMLATAWMYAAMNPRLLPVRSCTEYATEPDGSMPAMDMTAMNMPPNSGSPIWFSAVNWIGTVGFAVAAVFWACRFVMERRQEATQSRLPGSIGQAMMAAGMAMLFFAMLFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG26</accession>
    <name>A0A7U8TG26_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polyprenyl-diphosphate synthase grcC2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405136.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG26"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="325" mass="34743" checksum="95781FA134FBF960" modified="2021-06-02" version="1">MIPAVSLGDPQFTANVHDGIARITELINSELSQADEVMRDTVAHLVDAGGTPFRPLFTVLAAQLGSDPDGWEVTVAGAAIELMHLGTLCHDRVVDESDMSRKTPSDNTRWTNNFAILAGDYRFATASQLASRLDPEAFAVVAEAFAELITGQMRATRGPASHIDTIEHYLRVVHEKTGSLIAASGQLGAALSGAAEEQIRRVARLGRMIGAAFEISRDIIAISGDSATLSGADLGQAVHTLPMLYALREQTPDTSRLRELLAGPIHDDHVAEALTLLRCSPGIGKAKNVVAAYAAQAREELPYLPDRQPRRALATLIDHAVSACD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG83</accession>
    <name>A0A7U8TG83_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="135" mass="10717" checksum="3354E5B5023FB3DB" modified="2021-06-02" version="1">AGGAGGTGSTAGSGGSGGTNPPTGLQAAGGNGGSGHAGGHGGNGGGAGLLGGGGTGGNGGGGGQGGLGAAAGGVDGNGGNGGNGGKGGDAQLVGDGGNGGNGGKGGAGLIAGLDGAGGAGGTRGLIFGNAGTPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGB5</accession>
    <name>A0A7U8TGB5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03302</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405904.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGB5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026281">
        <property type="entry name" value="HTH_RamB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010359">
        <property type="entry name" value="IrrE_HExxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018653">
        <property type="entry name" value="ScfR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06114">
        <property type="entry name" value="Peptidase_M78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09856">
        <property type="entry name" value="ScfRs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019251">
        <property type="entry name" value="Rv0465c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="486" mass="54087" checksum="6F3CD3C041A1DEBB" modified="2021-06-02" version="1">MTRSNVLPVARTYSRTFSGARLRRLRQERGLTQVALAKALDLSTSYVNQLENDQRPITVPVLLLLTERFDLSAQYFSSDSDARLVADLSDVFTDIGVEHAVSGAQIEEFVARMPEVGHSLVAVHRRLRAATEELEGYRSRATAETELPPARPMPFEEVRDFFYDRNNYIHDLDMAAERMFTESGMRTGGLDIQLAELMRDRFGISVVIDDNLPDTAKRRYHPDTKVLRVAHWLMPGQRAFQIATQLALVGQSDLISSIVATDDQLSTEARGVARIGLANYFAGAFLLPYREFHRAAEQLRYDIDLLGRRFGVGFETVCHRLSTLQRPRQRGIPFIFVRTDKAGNISKRQSATAFHFSRVGGSCPLWVVHDAFAQPERIVRQVAQMPDGRSYFWVAKTTAADGLGYLGPHKNFAVGLGCDLAHAHKLVYSTGVVLDDPSTEVPIGAGCKICNRTSCAQRAFPYLGGRVAVDENAGSSLPYSSTEQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGB9</accession>
    <name>A0A7U8TGB9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="122" mass="12376" checksum="9D8B21CDC878C1D5" modified="2021-06-02" version="1">MLSARCHIRHIGSPGKDARCAHLSATLRPGIGISPTNVGNATVLADGTPAKPIQGAETMQRARHTGSCFSANARGPAISSGNPSRAGCGVPSSTTTPSSTPQAIRLLACTDSDALTVTRTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGE3</accession>
    <name>A0A7U8TGE3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03355</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019880">
        <property type="entry name" value="OxyQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03539">
        <property type="entry name" value="DapC_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="29"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="362" mass="37776" checksum="BB724D3D44C92857" modified="2021-06-02" version="1">MSASLPVFPWDTLADAKALAGAHPDGIVDLSVGTPVDPVAPLIQEALAAASAAPGYPATAGTARLRESVVAALARRYGITRLTEAAVLPVIGTKELIAWLPTLLGLGGADLVVVPELAYPTYDVGARLAGTRVLRADALTQLGPQSPALLYLNSPSNPTGRVLGVDHLRKVVEWARGRGVLVVSDECYLGLGWDAEPVSVLHPSVCDGEHTGLLAVHSLSKSSSLAGYRAGFVVGDLEIVAELLAVRKHAGMMVPAPVQAAMVAALDDDAHERQQRERYAQRRAALLPALGSAGFAVDYSDAGLYLWATRGEPCRDSVAWLAQRGILVAPGDFYGPGGAQHVRVALTATDERVAAAVGRLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGE4</accession>
    <name>A0A7U8TGE4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898753.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGE4"/>
    <dbReference type="GeneID" id="45425144"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="308" mass="31002" checksum="243C8CEF0E2CA90C" modified="2021-06-02" version="1">MSFVFAAPEALAAAAADMAGIGSTLNAANVVAAVPTTGVLAAAADEVSTQVAALLSAHAQGYQQLSRQMMTAFHDQFVQALRASADAYATAEASAAQTMVNAVNAPARALLGHPLISADASTGGGSNALSRVQSMFLGTGGSSALGGSAAANAAASGALQLQPTGGASGLSAVGALLPRAGAAAAAALPALAAESIGNAIKNLYNAVEPWVQYGFNLTAWAVGWLPYIGILAPQINFFYYLGEPIVQAVLFNAIDFVDGTVTFSQALTNIETATAASINQFINTEINWIRGFLPPLPPISPPGFPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGG2</accession>
    <name>A0A7U8TGG2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.117</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Tetrahydrodipicolinate N-succinyltransferase</fullName>
            <shortName evidence="4">THDP succinyltransferase</shortName>
            <shortName evidence="4">THP succinyltransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Tetrahydropicolinate succinylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dapD</name>
        <name evidence="6" type="ORF">TBLG_03377</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + succinyl-CoA = (S)-2-succinylamino-6-oxoheptanedioate + CoA</text>
            <dbReference type="Rhea" id="RHEA:17325"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15685"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="EC" id="2.3.1.117"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route): step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.117" evidence="4"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00019"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008666">
        <property type="term" value="F:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02122">
        <property type="entry name" value="DapD_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019875">
        <property type="entry name" value="DapD_actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032784">
        <property type="entry name" value="THDPS_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038361">
        <property type="entry name" value="THDPS_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026586">
        <property type="entry name" value="Type2_DapD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14789">
        <property type="entry name" value="THDPS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03535">
        <property type="entry name" value="DapD_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="4" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THDPS_M" evidence="5">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Succinyl-CoA binding" evidence="4">
        <location>
            <begin position="290"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-anhydride intermediate" evidence="4">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>ligand shared between trimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>succinyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="317" mass="32672" checksum="4E685BC7F7DF9EBD" modified="2021-06-02" version="1">MSTVTGAAGIGLATLAADGSVLDTWFPAPELTESGTSATSRLAVSDVPVELAALIGRDDDRRTETIAVRTVIGSLDDVAADPYDAYLRLHLLSHRLVAPHGLNASGLFGVLTNVVWTNHGPCAIDGFEAVRARLRRRGPVTVYGVDKFPRMVDYVVPTGVRIADADRVRLGAHLAPGTTVMHEGFVNYNAGTLGASMVEGRISAGVVVGDGSDVGGGASIMGTLSGGGTHVISIGKRCLLGANSGLGISLGDDCVVEAGLYVTAGTRVTMPDSNSVKARELSGSSNLLFRRNSVSGAVEVLARDGQGIALNEDLHAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGH5</accession>
    <name>A0A7U8TGH5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031095843" evidence="1">
        <location>
            <begin position="25"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="97" mass="9638" checksum="B3050F70E5DC1AD7" modified="2021-06-02" version="1">MLASAATDLAGIGSALSAANAAAAAPTTAMLAACADEVSAVVASLFARHAQAYQALSLQATAFHQQFVQALTGAGGAYCGCRSRQRCCGAERAARTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGJ3</accession>
    <name>A0A7U8TGJ3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein lprE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406334.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025971">
        <property type="entry name" value="LppP/LprE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14041">
        <property type="entry name" value="Lipoprotein_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031196297" evidence="2">
        <location>
            <begin position="33"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="202" mass="20442" checksum="E3DCE415A91DAAFE" modified="2021-06-02" version="1">MPGVWSPPCPTTPRVGVVAALVAATLTGCGSGDSTVAKTPEATPSLSTAHPAPPSSEPSPPSATAAPPSNHSAAPVDPCAVNLASPTIAKVVSELPRDPRSEQPWNPEPLAGNYNECAQLSAVVIKANTNAGNPTTRAVMFHLGKYIPQGVPDTYGFTGIDTSQCTGDTVALTYASGIGLNNVVKFRWNGGGVELIGNTTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGJ8</accession>
    <name>A0A7U8TGJ8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406302.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGJ8"/>
    <dbReference type="GeneID" id="45425211"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="86" mass="9918" checksum="7F72C309438595C2" modified="2021-06-02" version="1">MRTTLTLDDDVVRLVEDAVHRERRPMKQVINDALRRALAPPVKRQEQYRLEPHESAVRSGLDLAGFNKLADELEDEALLDATRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGK3</accession>
    <name>A0A7U8TGK3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6 9">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 6 9">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mdh</name>
        <name evidence="13" type="ORF">TBLG_03417</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6 9">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the LDH/MDH superfamily. MDH type 2 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 6 9"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406301.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGK3"/>
    <dbReference type="GeneID" id="45425210"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01517">
        <property type="entry name" value="Malate_dehydrog_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010945">
        <property type="entry name" value="Malate_DH_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23382">
        <property type="entry name" value="PTHR23382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01759">
        <property type="entry name" value="MalateDH-SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Ldh_1_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Ldh_1_C" evidence="12">
        <location>
            <begin position="157"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6 7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="329" mass="34322" checksum="0A512659617F9C37" modified="2021-06-02" version="1">MSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALQALEGVVMELDDCAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSDLLEANGAIFTAQGKALNAVAADDVRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNRAISQLAAKTGAAVTDIKKMTIWGNHSATQYPDLFHAEVAGKNAAEVVNDQAWIEDEFIPTVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLISSFPVTTKGGNWTIVSGLEIDEFSRGRIDKSTAELADERSAVTELGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGL9</accession>
    <name>A0A7U8TGL9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406558.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGL9"/>
    <dbReference type="GeneID" id="45425241"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025240">
        <property type="entry name" value="DUF4189"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13827">
        <property type="entry name" value="DUF4189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031321944" evidence="1">
        <location>
            <begin position="36"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4189" evidence="2">
        <location>
            <begin position="39"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="124" mass="12550" checksum="1BCECB3EFAE4FC0C" modified="2021-06-02" version="1">MTTMITLRRRFAVAVAGVATAAATTVTLAPAPANAADVYGAIAYSGNGSWGRSWDYPTRAAAEATAVKSCGYSDCKVLTSFTACGAVAANDRAYQGGVGPTLAAAMKDALTKLGGGYIDTWACN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGQ6</accession>
    <name>A0A7U8TGQ6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406937.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023845">
        <property type="entry name" value="DUF3817_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12823">
        <property type="entry name" value="DUF3817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03954">
        <property type="entry name" value="integ_memb_HG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3817" evidence="8">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="120" mass="13382" checksum="8D9C983C8E43EEAA" modified="2021-06-02" version="1">MTAPETPAAQHAEPAIAVERIRTALLGYRIMAWTTGLWLIALCYEIVVRYVVKVDNPPTWIGVVHGWVYFTYLLLTLNLAVKVRWPLGKTAGVLLAGTIPLLGIVVEHFQTKEIKARFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGS9</accession>
    <name>A0A7U8TGS9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="90" mass="9952" checksum="08965356EBC0C85D" modified="2021-06-02" version="1">MAAYAQMCSSDNAPGGNRDATAHHRWTPEASLRVLRGFWIALVPAPLSSNGRIRHQPFNLIFRGVSVAAMHTVRQRRGGARPTLTIVKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGT4</accession>
    <name>A0A7U8TGT4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="362"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="475" mass="51286" checksum="68DC38814EA477EC" modified="2021-06-02" version="1">MGNLDLLLRLSGRIVKGCRPLGSVALARCGPAVRWPWWPRPAILEHMFDLVSLAGVDSRDDEASLTARIAELERVKSAAAAGQARAAAALDKLRRCNEADAGVPARRRGRGVASEVALARRDSPARGGRHLGFAKALVYEMPHTLAALEVGRLSEWRATLIVRESACLDVEDRRALDAELCADMSALDGMGDARIAAAARAIAYRLDAQAVVERAARAETERTVTIRPAPDTMTWVTALLPVARGVSVYAALKRAADTTFDDRTRGQVMADTLVERVTGQPAEAAQPVAVNLVLSDETLLAGDRAPAVVDGYGPIPAAVARNLVRDAVADTRSRATLRRLYRHPRSGALVAMESRARRFPKGLAAFIGLRDQRCRMPYCDAPIRHRDHAQPHHRGGPTTATNGLGSCERCNYVKEAPGWRVSTDTDETGRHTAEFTTPTGMYYHCTAPPLPGPLEIDVSQVEARIGVALTHLHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGX6</accession>
    <name>A0A7U8TGX6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403482.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGX6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041347">
        <property type="entry name" value="MftR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023851">
        <property type="entry name" value="Tscrpt_reg_TetR-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17754">
        <property type="entry name" value="TetR_C_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03968">
        <property type="entry name" value="mycofact_TetR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="198" mass="22264" checksum="0167B32FB5687C2A" modified="2021-06-02" version="1">MPHESRVGRRRSTTPHHISDVAIELFAAHGFTDVSVDDIARAAGIARRTLFRYYASKNAIPWGDFSTHLAQLQGLLDNIDSRIQLRDALRAALLAFNTFDESETIRHRKRMRVILQTPELQAYSMTMYAGWREVIAKFVARRSGGKTTDFMPQTVAWTMLGVALSAYEHWLRDESVSLTEALGAAFDVVGAGLDRLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH46</accession>
    <name>A0A7U8TH46_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="347" mass="37742" checksum="B8B9DBC7EB1DB436" modified="2021-06-02" version="1">MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEYGFDSVWLCDHFLKISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLPLLECWTALAALSRDTTKLRLGTSVLCNSYRHPSVLAKMAATLDVISQGRLDLGLGAGWFRRESQAYGIPFPPVGDRVSALAESLQVIKAVWTEPNPTYAGRFYTLDGATCDPPPVQRPHPPLWIGGEGDRVQRIAAKHAQGLNVRWWSPQQVTQRRGFLTQASEAAGRDPDTLRLSVTLLLAPTQSGEEEVRIREEFASIPEPGLIVGTPDRCVERIREYQDRGVGHFLFTIPHVVKSDYLHIIGSDIIPRVKTEVTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH49</accession>
    <name>A0A7U8TH49_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403210.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH49"/>
    <dbReference type="GeneID" id="45424577"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="80" mass="8254" checksum="B0AB24D7A7260F50" modified="2021-06-02" version="1">MMDVLAAGIAAGALTLAAWGAWRPHYRAASYLVAGAVELALIGLLVVTGQTLMAISVAFLVALGGPLVVVNHRRAERSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THB8</accession>
    <name>A0A7U8THB8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase atsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898561.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THB8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="37"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="787" mass="86214" checksum="9782187FEF9EE792" modified="2021-06-02" version="1">MAPEATEAFNGTIELDIRDSEPDWGPYAAPVAPEHSPNILYLVWDDVGIATWDCFGGLVEMPAMTRVAERGVRLSQFHTTALCSPTRASLLTGRNATTVGMATIEEFTDGFPNCNGRIPADTALLPEVLAEHGYNTYCVGKWHLTPLEESNMASTKRHWPTSRGFERFYGFLGGETDQWYPDLVYDNHPVSPPGTPEGGYHLSKDIADKTIEFIRDAKVIAPDKPWFSYVCPGAGHAPHHVFKEWADRYAGRFDMGYERYREIVLERQKALGIVPPDTELSPINPYLDVPGPNGETWPLQDTVRPWDSLSDEEKKLFCRMAEVFAGFLSYTDAQIGRILDYLEESGQLDNTIIVVISDNGASGEGGPNGSVNEGKFFNGYIDTVAESMKLFDHLGGPQTYNHYPIGWAMAFNTPYKLFKRYASHEGGIADPAIISWPNGIAAHGEIRDNYVNVSDITPTVYDLLGMTPPGTVKGIPQKPMDGVSFIAALADPAADTGKTTQFYTMLGTRGIWHEGWFANTIHAATPAGWSNFNADRWELFHIAADRSQCHDLAAEHPDKLEELKALWFSEAAKYNGLPLADLNLLETMTRSRPYLVSERASYVYYPDCADVGIGAAVEIRGRSFAVLADVTIDTTGAEGVLFKHGGAHGGHVLFVRDGRLHYVYNFLGERQQLVSSSGPVPSGRHLLGVRYLRTGTVPNSHTPVGDLELFFDENLVGALTNVLTHPGTFGLAGAAISVGRNGGSAVSSHYEAPFAFTGGTITQVTVDVSGRPFEDVESDLALAFSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THE7</accession>
    <name>A0A7U8THE7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PPE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="649" mass="63022" checksum="3048467839061A53" modified="2021-06-02" version="1">MPPETNSLRMYLGAGSRPLLAAAGAWDGLAEELHAAASSFGSVTSELAGGAWQGPASAAMANAAGPYASWLTAAGAQAELAARQARAAAGAFEEALAGVVHPAVVQANRVRTWLLAVSNVFGQNAPAIAAMESTYEQMWAQDVAVMAGYHAASSAAAAQLASWQPALPNINLGVGNIGNLNVGNGNTGDYNLGNGNLGNANFGGGNGSAFHGQISSFNVGSGNIGNFNLGSGNGNVGIGPSSFNVGSGNIGNANVGGGNSGDNNFGFGNFGNANIGIGNAGPNMSSPAVPTPGNGNVGIGNGGNGNFGGGNTGNANIGLGNVGDGNVGFGNSGSYNFGFGNSGSYNFGFGNTGNNNIGIGLTGSNQIGFGGLNSGSGNIGFGNSGTGNIGFFNSGSGNFGVGNSGVTNTGVANSGNINTGFGNSGFINTGFGNALSVNTGFGNSGQANTGIGNAGDFNTGNFNGGIINTGSFNSGAFNSGSFNGGDANSGFLNSGLTNTGFANSGNINTGGFNAGNLNTGFGNTTDGLGENSGFGNAGSGNSGFNNSGKGNSGAQNVGNLQISGFANSGQSVTGYNNSVSVTSGFGNKGTGLFSGFMSGFGNTGFLQSGFGNLEANPDNNSATSGFGNSGKQDSGGFNSIDFVSGFFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THU1</accession>
    <name>A0A7U8THU1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019920">
        <property type="entry name" value="F420-binding_dom_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03618">
        <property type="entry name" value="Rv1155_F420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="138" mass="15237" checksum="42E4A6EDF18496E4" modified="2021-06-02" version="1">MLAVISGNSIGVLATIKHDGRPQLSNVQYHFDPRKLLIQVSIAEPRAKTRNLRRDPRASILVDADDGWSYAVAEGTAQLTPPAAAPDDDTVEALIALYRNIAGEHPDWDDYRQAMVTDRRVLLTLPISHVYGLPPGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI36</accession>
    <name>A0A7U8TI36_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="120" mass="11821" checksum="B7A39728B02E1807" modified="2021-06-02" version="1">SFAGAEAANASQLQSIARQVRGAVNAVAGQVTGNGGSGNSGTSAAAANPNSDNTASIADRGTSAIMTTASATASSTGVDGGIAATYAVASQWDDGYVANYTITQFGRDFDDRLAVAIHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI99</accession>
    <name>A0A7U8TI99_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alternative RNA polymerase sigma factor sigI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03365</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI99"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="290" mass="31431" checksum="5120BD4F8A374F8C" modified="2021-06-02" version="1">MSQHDPVSAAWRAHRAYLVDLAFRMVGDIGVAEDMVQEAFSRLLRAPVGDIDDERGWLIVVTSRLCLDHIKSASTRRERPQDIAAWHDGDASVSSVDPADRVTLDDEVRLALLIMLERLGPAERVVFVLHEIFGLPYQQIATTIGSQASTCRQLAHRARRKINESRIAASVEPAQHRVVTRAFIEACSNGDLDTLLEVLDPGVAGEIDARKGVVVVGADRVGPTILRHWSHPATVLVAQPVCGQPAVLAFVNRALAGVLALSIEAGKITKIHVLVQPSTLDPLRAELGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIB1</accession>
    <name>A0A7U8TIB1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Esterase lipO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Abhydrolase_3" evidence="2">
        <location>
            <begin position="182"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD13030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="420" mass="46157" checksum="EE72C5ABAB114BF6" modified="2021-06-02" version="1">MRFRRMARPRPLTRAAVELLNAANGLRPLSGSGYSTVLAFWLGWPTSEVPGVYLGASVLDALRRGRRGDFGGLKGKAALALTAAAWVILAVIRYRGATTPGPVLEAGLTEQLGPDYAKELATLPTEPMRSRGRNLPLRTAMARRRYVETTNVVCYGPYGRANLADIWRRRDLPRDAKAPVLVQVPGGAWVLGWRRPQAYPLMSHLAARGWVCVSLNYRVSPRHTWPDHIVDVKRALAWVKENIAAYGGDPNFVAISGGSAGGHLYALAALTPNDPRFQPGFEQVDTSVAAAVPVYGRYDWFTTDAPGRREFVGLLETFVVKRKFSTHRDIFVDASPIHHVRADAPPFFVLHGRHDSLIPVAEAHAFVEELRAVSKSPVAYADLPHAQHAFDVFGSPRAHHTAEAVARFLSWVYATNPPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR12</accession>
    <name>A0A7U8TR12_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03642</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="364" mass="39888" checksum="BFF81B92BD46676A" modified="2021-06-02" version="1" fragment="single">MGGHRVILRNDQQKSIEGNDAMTSSHLIDAEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALCGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIGSNNPQERLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR33</accession>
    <name>A0A7U8TR33_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="134" mass="14571" checksum="D67E559FEBF4BB48" modified="2021-06-02" version="1">MSVAGDISGQTGMAAAEVICDTPPRCSSQAYDQGISKMLFRTSCISSPCHPLGVVFSSTGRSQVHQVSPDPRGAMNFPASASPGRRTWSRYDGNLEPCRAAQHIEDALLESLPDPVRFPISAKERYAHDRDRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR39</accession>
    <name>A0A7U8TR39_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">TBLG_03689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416045.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR39"/>
    <dbReference type="GeneID" id="45427063"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD14791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="132" mass="14301" checksum="CA9B283379B0174E" modified="2021-06-02" version="1">MPNHDYRELAAVFAGGALGALARAALSALAIPDPARWPWPTFTVNVVGAFLVGYFTTRLLERLPLSSYRRPLLGTGLCGGLTTFSTMQVETISMIEHGHWGLAAAYSVVSITLGLLAVHLATVLVRRVRIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR47</accession>
    <name>A0A7U8TR47_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyl-CoA dehydrogenase fadE22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003902404.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR47"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="6"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="204"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="7">
        <location>
            <begin position="367"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="461"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="567"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="721" mass="76741" checksum="D9F6942BFD9885B7" modified="2021-06-02" version="1">MGIALTDDHRELSGVARAFLTSQKVRWAARASLDAAGDARPPFWQNLAELGWLGLHIDERHGGSGYGLSELVVVIEELGRAVAPGLFVPTVIASAVVAKEGTDDQRARLLPALIDGTLTAGVGLDSQVQVTDGVADGEAGIVLGAGLAELLLVAAGDDVLVLERGRKGVSVDVPENFDPTRRSGRVRLDNVRVTTDDILLGAYESALARARTLLAAEAVGGAADCVDSAVAYAKVRQQFGRTIATFQAVKHHCANMLVAAESAIAAVWDAARAAAEDEEQFRLAAAVAAALAFPAYARNAELNIQVHGGIGFTWEHDAHLHLRRALVTVGLFGGDAPVRDVFERTAAGVTRAISLDLPAQAEELRARIRSDAAEIAALEKDAQRDKLIETGYVMPHWPRPWGRAAGAVEQLVIEEEFSAAGIERPDYSITGWVILTLIQHGTPWQIERFVEKALRQQEIWCQLFSEPDAGSDAASVKTRATRVEGGWKINGQKVWTSGAQYCARGLATVRTDPDAPKHAGITTVIIDMLAPGVEVRPLRQITGDSEFNEVFFNDVFVPDEDVVGAPNSGWTVARATLGNERVSIGGSGSYYEAMAAKLVQLVQRRSDAFAGAPIRVGAFLAEDHALRLLNLRRAARSVEGAGPGPEGNITKLKVAEHMIEGAAIAAALWGPEIALLDGPGRVIGRTVMGARGMAIAGGTSEVTRNQIAERILGMPRDPLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR58</accession>
    <name>A0A7U8TR58_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899911.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="150" mass="15728" checksum="217F6C5122291862" modified="2021-06-02" version="1">MASLRIAEVDPVDRSPNHHASGSVETSSSRSRSASVRACLIHTSRSSSCSARRMTSLLRSPLRIAALMICSSFSVGRKPMVAVMSTTIADVAQSYSNCSTHSGTPTPAFAASFLLDAINAPRVIAGRFASESVRFPAAAPHGSVPSRLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR65</accession>
    <name>A0A7U8TR65_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HpcH_HpaI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416052.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR65"/>
    <dbReference type="GeneID" id="45427071"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011206">
        <property type="entry name" value="Citrate_lyase_beta/mcl1/mcl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015582">
        <property type="entry name" value="Cit_lyase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH_HpaI" evidence="5">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015582-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="307" mass="33100" checksum="F1297521EC375EE6" modified="2021-06-02" version="1">MTSMYEQVDTNTADPVAGSRIDPVLARSWLLVNGAHGDRFESAAHSRADIVVLDIEDAVAPKDKHAARDNAVRWFGDGNADWVRINGFGTPWWADDLAMLADSPVGGVMLAMVESVDHVTETAKRLPNVPIVALVETARGLERINEIAAAKGTFRLAFGIGDFRRDTGFGEDPATLAYARSRFTIAARAAGLPSAIDGPTIGSNALKLIEATAVSAEFGMTGKICLSPDQCPVVNEGLSPSQDEIVWAKEFFAEFARDGGEIRNGSDLPRIARATKILDLARAYGIEVSDFEDEPVHMPAPTDTYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR80</accession>
    <name>A0A7U8TR80_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="119"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="221" mass="24498" checksum="F9AA28F4D6B533DD" modified="2021-06-02" version="1">GLGRSVAKRRRKPRSLKYSYDALKVLQRVWSASGGQCGKYLAASMVLQLDGLERHGVLEFGRDRYGPEVREELLAMSAASIDRYLKTAKAKDQISGVSTTKPSPLLRNSIKVRRAGDEVEAEPGFFEGDTVAHCGPTLKGEFAHTLNLTDVHIGWVFTRTVRNNARTHILAGLKASVTEIPHGITGLDFDNGTVFLNKPVISWAGDNGIYFTRFRPYKKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRB3</accession>
    <name>A0A7U8TRB3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416605.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="374" mass="41760" checksum="15800299C0C8D334" modified="2021-06-02" version="1">MPQMLGPLDEYPLHQLPQPIAWPGSSDRNFYDRSYFNAHDRTGNIFLITGIGYYPNLGVKDAFVLIRRADIQTAVHLSDAIDSDRLHQHVNGYRVEVVEPLRKLRIVLDETEGVAADLTWEGLFDVVQEQPHVLRSGNRVTLDAQRFAQLGTWSGRIVVDGERIAVDPATWLGSRDRSWGIRPVGEPEPAGRPADPPFEGMWWLYVPLAFDDFAVVLIIQEEPDGFRSLNDCTRIWRDGHVEQLGWPRVRIHYRSGTRIPTGATIEASTPDGAPVHFDVESKLAVPTHVGGGYGGDSDWSHGMWKGEKFVERRTYDMTDPTIIARAGFGVIDHVGRALCRDGDGNPVQGWGLFEHGALGRHDPSGFADWSTLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRB4</accession>
    <name>A0A7U8TRB4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADPH:adrenodoxin oxidoreductase fprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03727</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 8" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031377279" evidence="9">
        <location>
            <begin position="26"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="10">
        <location>
            <begin position="6"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="199"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="366"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD14829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="456" mass="49342" checksum="FE7B1A281F78BFB7" modified="2021-06-02" version="1">MRPYYIAIVGSGPSAFFAAASLLKAADTTEDLDMAVDMLEMLPTPWGLVRSGVAPDHPKIKSISKQFEKTAEDPRFRFFGNVVVGEHVQPGELSERYDAVIYAVGAQSDRMLNIPGEDLPGSIAAVDFVGWYNAHPHFEQVSPDLSGARAVVIGNGNVALDVARILLTDPDVLARTDIADHALESLRPRGIQEVVIVGRRGPLQAAFTTLELRELADLDGVDVVIDPAELDGITDEDAAAVGKVCKQNIKVLRGYADREPRPGHRRMVFRFLTSPIEIKGKRKVERIVLGRNELVSDGSGRVAAKDTGEREELPAQLVVRSVGYRGVPTPGLPFDDQSGTIPNVGGRINGSPNEYVVGWIKRGPTGVIGTNKKDAQDTVDTLIKDLGNAKEGAECKSFPEDHADQVADWLAARQPKLVTSAHWQVIDAFERAAGEPHGRPRVKLASLAELLRIGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRC0</accession>
    <name>A0A7U8TRC0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="27"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="210"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="429" mass="48053" checksum="B662D9374654987C" modified="2021-06-02" version="1">MVHDEAGHELIERHMLEQLREVAEYTRVVLINGPRQAGKTTLLQQLHAELGGWLRSLDVDVERASARADPEGYIMSAPRPTFLDEVQCAGDPLILAIKTATDRDRRPRQFFLSGSTRFLTVPTLSESLAGRVAILDLWPLSVAERSGVRPEIIAQLFTEPQVVLGTEPAPVTRHEYLQLACAGGFPEVVQRPAGRARSRWFSDYLRTVTQRDVRELKRIEQTDRLPRFMRYLAAITAQELNVAEAARVIGVDAGTIRSDLALFETVYLVHRLPAWSRNLTAKIKKRSKIHVVDSGFAAWLRGQSADSLARPTAEGAGPIMETFVINELMKLRAATELEVDLYHFRDRDGREIDCILQTPDSRVVGVEVKASATVNVHDFRHLSFARDRLGDEFITGVLFYTGARALPFGDRLMALPINLLWNGQSVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRG2</accession>
    <name>A0A7U8TRG2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416635.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427167"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="97" mass="10551" checksum="462CC708BE8031A0" modified="2021-06-02" version="1">MTAAEDKEERLRLSGTRIELEELLQLPVDVAYEGLLTDDVSESVRKKLITLRAGPSRTACSNLRNPAGVGADDGARRDVVHQRDIADGTGVEPATHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRK6</accession>
    <name>A0A7U8TRK6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="2">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03905</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="2"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRK6"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="3">
        <location>
            <begin position="7"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="304" mass="32055" checksum="63BA888674599E0A" modified="2021-06-02" version="1">MAGRSERLVITGAGGQLGSHLTAQAAREGRDMLALTSSQWDITDPAAAERIIRHGDVVINCAAYTDVDGAESNEAVAYAVNATGPQHLARACARVGARLIHVSTDYVFDGDFGGAEPRPYEPTDETAPQGVYARSKLAGEQAVLAAFPEAAVVRTAWVYTGGTGKDFVAVMRRLAAGHGRVDVVDDQTGSPTYVADLAEALLALADAGVRGRVLHAANEGVVSRFGQARAVFEECGADPQRVRPVSSAQFPRPAPRPSYSALSSRQWALAGLTPLRHWRSALATALAAPANSTSIDRRLPSTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN7</accession>
    <name>A0A7U8TRN7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03998</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900048.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRN7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="412" mass="44897" checksum="D0A76046EF800FF2" modified="2021-06-02" version="1">MKIRTLSGSVLEPPSAVRATPGTSMLKLEPGGSTIPKIPFIRPSFPGPAELAEDFVQIAQANWYTNFGPNERRFARALRDYLGPHLHVATLANGTLALLAALHVSFGAGTRDRYLLMPSFTFVGVAQAALWTGYRPWFIDIDANTWQPCVHSARAVIERFRDRIAGILLANVFGVGNPQISVWEELAAEWELPIVLDSAAGFGSTYADGERLGGRGACEIFSFHATKPFAVGEGGALVSRDPRLVEHAYKFQNFGLVQTRESIQLGMNGKLSEISAAIGLRQLVGLDRRLASRRKVLECYRTGMADAGVRFQDNANVASLCFASACCTSADHKAAVLGSLRRHAIEARDYYNPPQHRHPYFVTNAELVESTDLAVTADICSRIVSLPVHDHMAPDDVARVVAAVQEAEVRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRP3</accession>
    <name>A0A7U8TRP3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="3 5">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">moaC</name>
        <name evidence="8" type="ORF">TBLG_03965</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="3 5"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417293.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRP3"/>
    <dbReference type="GeneID" id="45427324"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoaC" evidence="7">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="116"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="177" mass="18555" checksum="6A5996E02C2D61B5" modified="2021-06-02" version="1">MNDHDGVLTHLDEQGAARMVDVSAKAVTLRRARASGAVLMKPSTLDMICHGTAAKGDVIATARIAGIMAAKRTGELIPLCHPLGIEAVTVTLEPQGADRLSIAATVTTVARTGVEMEALTAVTVTALTVYDMCKAVDRAMTITDIRLDEKSGGRSGHYRRHDADVKPSDGGSTEDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRP7</accession>
    <name>A0A7U8TRP7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Chaperonin-10</fullName>
            <shortName evidence="3">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">groES</name>
        <name evidence="3" type="synonym">groS</name>
        <name evidence="5" type="ORF">TBLG_03981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418028.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRP7"/>
    <dbReference type="GeneID" id="45427414"/>
    <dbReference type="GeneID" id="66599586"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="100" mass="10804" checksum="DE448187A56103FE" modified="2021-06-02" version="1">MAKVNIKPLEDKILVQANEAETTTASGLVIPDTAKEKPQEGTVVAVGPGRWDEDGEKRIPLDVAEGDTVIYSKYGGTEIKYNGEEYLILSARDVLAVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRS1</accession>
    <name>A0A7U8TRS1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="3">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2642"/>
            <end position="2671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="2671" mass="261711" checksum="6146E22DDAC18706" modified="2021-06-02" version="1">MEFPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEELGSAAVSFGQVTSGLTAGVWQGAAAAAMAAAAAPYAGWLGSVAAAAEAVAGQARVVVGVFEAALAATVDPALVAANRARLVALAVSNLLGQNTPAIAAAEAEYELMWAADVAAMAGYHSGASAAAAALPAFSPPAQALGGGVGAFLTALFASPAKALSLNAGLGNVGNYNVGLGNVGVFNLGAGNVGGQNLGFGNAGGTNVGFGNLGNGNVGFGNSGLGAGLAGLGNIGLGNAGSSNYGFANLGVGNIGFDNTGTNNVGVGLTGNHLTGIGGLNSGTGNIGLFNSGTGNVGFFNSGTGNFGVFNSGNYNTGVGNAGTASTGLFNAGNFNTGVVNVGSYNTGSFNAGDTNTGGFNPGGVNTGWLNTGNTNTGIANSGNVNTGAFISGNFNNGVLWVGDYQGLFGVSAGSSIPAIPIGLVLNGDIGPITIQPIPILPTIPLSIHQTVNLGPLVVPDIVIPAFGGGIGIPINIGPLTITPITLFAQQTFVNQLPFPTFSLGKITIPQIQTFDSNGQLVSFIGPIVIDTTIPGPTNPQIDLTIRWDTPPITLFPNGISAPDNPLGLLVSVSISNPGFTIPGFSVPAQPLPLSIDIEGQIDGFSTPPITIDRIPLTVGGGVTIGPITIQGLHIPAAPGVGNTTTAPSSGFFNSGAGGVSGFGNVGAGSSGWWNQAPSALLGAGSGVGNVGTLGSGVLNLGSGISGFYNTSVLPFGTPAAVSGIGNLGQQLSGVSAAGTTLRSMLAGNLGLANVGNFNTGFGNVGDVNLGAANIGGHNLGLGNVGDGNLGLGNIGHGNLGFANLGLTAGAAGVGNVGFGNAGINNYGLANMGVGNIGFANTGTGNIGIGLVGDHRTGIGGLNSGIGNIGLFNSGTGNVGFFNSGTGNFGIGNSGRFNTGIGNSGTASTGLFNAGSFSTGIANTGDYNTGSFNAGDTNTGGFNPGGINTGWFNTGHANTGLANAGTFGTGAFMTGDYSNGLLWRGGYEGLVGVRVGPTISQFPVTVHAIGGVGPLHVAPVPVPAVHVEITDATVGLGPFTVPPISIPSLPIASITGSVDLAANTISPIRALDPLAGSIGLFLEPFRLSDPFITIDAFQVVAGVLFLENIIVPGLTVSGQILVTPTPIPLTLNLDTTPWTLFPNGFTIPAQTPVTVGMEVANDGFTFFPGGLTFPRASAGVTGLSVGLDAFTLLPDGFTLDTVPATFDGTILIGDIPIPIIDVPAVPGFGNTTTAPSSGFFNTGGGGGSGFANVGAGTSGWWNQGHDVLAGAGSGVANAGTLSSGVLNVGSGISGWYNTSTLGAGTPAVVSGIGNLGQQLSGFLANGTVLNRSPIVNIGWADVGAFNTGLGNVGDLNWGAANIGAQNLGLGNLGSGNVGFGNIGAGNVGFANSGPAVGLAGLGNVGLSNAGSNNWGLANLGVGNIGLANTGTGNIGIGLVGDYQTGIGGLNSGSGNIGLFNSGTGNVGFFNTGTGNFGLFNSGSFNTGIGNSGTGSTGLFNAGNFNTGIANPGSYNTGSFNVGDTNTGGFNPGDINTGWFNTGIMNTGTRNTGALMSGTDSNGMLWRGDHEGLFGLSYGITIPQFPIRITTTGGIGPIVIPDTTILPPLHLQITGDADYSFTVPDIPIPAIHIGINGVVTVGFTAPEATLLSALKNNGSFISFGPITLSNIDIPPMDFTLGLPVLGPITGQLGPIHLEPIVVAGIGVPLEIEPIPLDAISLSESIPIRIPVDIPASVIDGISMSEVVPIDASVDIPAVTITGTTISAIPLGFDIRTSAGPLNIPIIDIPAAPGFGNSTQMPSSGFFNTGAGGGSGIGNLGAGVSGLLNQAGAGSLVGTLSGLGNAGTLASGVLNSGTAISGLFNVSTLDATTPAVISGFSNLGDHMSGVSIDGLIAILTFPPAESVFDQIIDAAIAELQHLDIGNALALGNVGGVNLGLANVGEFNLGAGNVGNINVGAGNLGGSNLGLGNVGTGNLGFGNIGAGNFGFGNAGLTAGAGGLGNVGLGNAGSGSWGLANVGVGNIGLANTGTGNIGIGLTGDYRTGIGGLNSGTGNLGLFNSGTGNIGFFNTGTGNFGLFNSGSYSTGVGNAGTASTGLFNAGNFNTGLANAGSYNTGSLNVGSFNTGGVNPGTVNTGWFNTGHTNTGLFNTGNVNTGAFNSGSFNNGALWTGDYHGLVGFSFSIDIAGSTLLDLNETLNLGPIHIEQIDIPGMSLFDVHEIVEIGPFTIPQVDVPAIPLEIHESIHMDPIVLVPATTIPAQTRTIPLDIPASPGSTMTLPLISMRFEGEDWILGSTAAIPNFGDPFPAPTQGITIHTGPGPGTTGELKISIPGFEIPQIATTRFLLDVNISGGLPAFTLFAGGLTIPTNAIPLTIDASGALDPITIFPGGYTIDPLPLHLALNLTVPDSSIPIIDVPPTPGFGNTTATPSSGFFNSGAGGVSGFGNVGSNLSGWWNQAASALAGSGSGVLNVGTLGSGVLNVGSGVSGIYNTSVLPLGTPAVLSGLGNVGHQLSGVSAAGTALNQIPILNIGLADVGNFNVGFGNVGDVNLGAANLGAQNLGLGNVGTGNLGFANVGHGNIGFGNSGLTAGAAGLGTRGSAMPAAPTMVSPTRACATSGWPTPAPATSGSGWWGTTSPASGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRU4</accession>
    <name>A0A7U8TRU4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="18"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="2023" mass="202988" checksum="F9FB695FF582F62E" modified="2021-06-02" version="1">MSRSHNLGSDTGRHTPYFGNAGRIGPAAAADHRRHRIAGNLVQPIHTHRHSADRHPGLHYQRNFDVGGRADRCVRRHSGGHHHRHQDRPDSAELRRSQQRRTHQHLDHRHSGAAGLWQLDRAAVVGLLQHRRRWRLGHRQLRRGGVRLAEPGLESDGGDALRPGQCRQPGIRCAELRRRHLGHVQREHAGLRAGGDLGFRQPGQPRVGGVHRWPAGDADQRRVGRLRAAEHHRRGDRRAAAPESAEHRQPGQRRQLQPRLRQRRRRQPGARATSATSTSAVATSAGRTWGWATSGTATSGSAPRPRHVGFGNSGLGALPGIGNIGLGNAGSNNVGFGNMGLGNIGFGNTGTNNLGIGLTGDNQTGFGGLNSGAGNLGLFNSGTGNIGFFNTGTGNWGLFNSGSYNTGIGNSGTGSTGLFNAGSFNTGLANAGSYNTGSLNAGNTNTGGFNPGNVNTGWFNAGHTNTGGFNTGNVNTGAFNSGSFNNGALWTGDHHGLVGFSYSIEITGSTLVDINETLNLGPVHIDQIDIPGMSLFDIHELVNIGPFRIEPIDVPAVVLDIHETMVIPPIVFLPSMTIGGQTYTIPLDTPPAPAPPPFRLPLLFVNALGDNWIVGASNSTGMSGGFVTAPTQGILIHTGPSSATTGSLALTLPTVTIPTITTSPIPLKIDVSGGLPAFTLFPGGLNIPQNAIPLTIDASGVLDPITIFPGGFTIDPLPLSLALNISVPDSSVPIIIVPPTPGFGNATATPSSGFFNSGAGGVSGFGNFGAGSSGWWNQAHAALAGAGSGVLNVGTLNSGVLNVGSGISGLYNTAIVGLGTPALVSGAGNVGQQLSGVLAAGTALTQSPIINLGLADVGNYNLGLGNVGDFNLGAANLGDLNLGLGNIGNANVGFGNIGHGNVGFGNSGLGAALGIGNIGLGNAGSTNVGLANMGVGNIGFANTGTNNLGIGLTGDNQTGIGGLNSGAGNLGLFNSGAGNVGFFNSGTGNWGLFNSGSFNTGIGNSGTGSTGLFNAGGFTTGLANAGSYNTGSFNVGDTNTGGFNPGSINTGWFNTGNANTGIANSGNVDTGALMSGNFSNGILWRGNYEGLFSYSYSLDVPRITILDAHFTGAFGPVVVPPIPVPAINAHLTGNAAMGAFTIPQIDIPALNPNVTGSVGFGPIAVPSVTIPALTAARAVLDMAASVGATSEIEPFIVWTSSGAIGPTWYSVGRIYNAGDLFVGGNIISGIPTLSTTGPVHAVFNAASQAFNTPALNIHQIPLGFQVPGSIDAITLFPGGLTFPANSLLNLDVFVGTPGATIPAITFPEIPANADGELYVIAGNIPLINIPPTPGIGNTTTVPSSGFFNTGAGGGSGFGNFGANMSGWWNQAHTALAGAGSGIANVGTLHSGVLNLGSGLSGIYNTSTLPLGTPALVSGLGNVGDHLSGLLASNLGQNPITIVNIGLANVGNGNVGLGNIGNLNLGAANIGDVNLGFGNIGDVNLGFGNIGGGNVGFGNIGDANFGFGNSGLAAGLAGMGNIGLGNAGSGNVGWANMGLGNIGFGNTGTNNLGIGLTGDNQSGIGGLNSGTGNIGLFNSGTGNIGFFNSGTANFGLFNSGSYNTGIGNSGVASTGLVNAGGFNTGVANAGSYNTGSFNAGDTNTGGFNPGSTNTGWFNTGNANTGVANAGNVNTGALITGNFSNGILWRGNYEGLAGFSFGYPIPLFPAVGADVTGDIGPATIIPPIHIPSIPLGFAAIGHIGPISIPNIAIPSIHLGIDPTFDVGPITVDPITLTIPGLSLDAAVSEIRMTSGSSSGFKVRPSFSFFAVGPDGMPGGEVSILQPFTVAPINLNPTTLHFPGFTIPTGPIHIGLPLSLTIPGFTIPGGTLIPQLPLGLGLSGGTPPFDLPTVVIDRIPVELHASTTIGPVSLPIFGFGGAPGFGNDTTAPSSGFFNTGGGGGSGFSNSGSGMSGVLNAISDPLLGSASGFANFGTQLSGILNRGAGISGVYNTGTLGLVTSAFVSGFMNVGQQLSGLLFAGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRV0</accession>
    <name>A0A7U8TRV0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663495">
        <property type="protein sequence ID" value="EFD15162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="349" mass="27938" checksum="E809029DEF14AC02" modified="2021-06-02" version="1" fragment="single">MKGATGADGTAPTSGGDGGNGGNGASPTVAGGNGGDGGKGGSGGNVGNGGNGGAGGNGAAGQAGTPGPTSGDSGTSGTDGGAGGNGGAGGAGGTLAGHGGNGGKGGNGGQGGIGGAGERGADGAGPNANGANGENGGSGGNGGDGGAGGNGGAGGKAQAAGYTDGATGTGGDGGNGGDGGKAGDGGAGENGLNSGAMLPGGGTVGNPGTGGNGGNGGNAGVGGTGGKAGTGSLTGLDGTDGITPNGGNGGNGGNGGKGGTAGNGSGAAGGNGGNGGSGLNGGDAGNGGNGGGALNQAGFFGTGGKGGNGGNGGAGMINGGLGGFGGAGGGGAVDVAATTGGAGGNGGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRZ0</accession>
    <name>A0A7U8TRZ0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="134"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="387" mass="43350" checksum="F3432D28B809BDE8" modified="2021-06-02" version="1">MIDTAIEEMIPLIGVRAACAATGRAPASYYRAHSKRLSAQSDTFTSTAVTDPSGPRESAQPRALSAAEREHVLAVLNSQRFADMAPAVVYATLLDEGIYLCSESTMYRLLRERGQTGDRRRQATHPAAVKPELVAHQPNSVWSWDITKLRGPAKWSYYYLYVILDIFSRYVVGWMVASRESKVLAERLIAQTLAAQHISADQLTLHADRGSSMSSKPVALLLADLGVTKSHSRPHTSNDNPLSEAQFKTLKYRPDFPKRFESIEAARVHCDRFFGWYNHEHKHSGIGLHTPADVHYGRADQIRRHRATVLDTAYRDHLERIRSQTTRATRATGLQRDQPTTEGGPADSINPRKSCLRNVDRFRPGLLDLPAPAPVDLRRLLPSGQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TST5</accession>
    <name>A0A7U8TST5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="146" mass="16138" checksum="6EFF87B2111A4F34" modified="2021-06-02" version="1">MTPNAASTGDSAKNTITGCCLITARALVARTRSISLPGMPFRMPADYHNASSDEPTNRHPWPAPARCCRHEWRTMRRTNACDRRRFGLSLTIHEDACRIISVVPVVLEVRRAEPAHPATPYPEPLARCSRSPGLNESSHMSGRIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSW8</accession>
    <name>A0A7U8TSW8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit H</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit H</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoH</name>
        <name evidence="8" type="ORF">TBLG_03774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cell membrane</location>
            <topology evidence="5 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TSW8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="410" mass="44658" checksum="8D3B863AA0B48BBD" modified="2021-06-02" version="1">MTTFGHDTWWLVAAKAIAVFVFLMLTVLVAILAERKLLGRMQLRPGPNRVGPKGALQSLADGIKLALKESITPGGIDRFVYFVAPIISVIPAFTAFAFIPFGPEVSVFGHRTPLQITDLPVAVLFILGLSAIGVYGIVLGGWASGSTYPLLGGVRSTAQVISYEVAMGLSFATVFLMAGTMSTSQIVAAQDGVWYAFLLLPSFVIYLISMVGETNRAPFDLPEAEGELVAGFHTEYSSLKFAMFMLAEYVNMTTVSALAATLFFGGWHAPWPLNMWASANTGWWPLIWFTAKVWGFLFIYFWLRATLPRLRYDQFMALGWKLLIPVSLVWVMVAAIIRSLRNQGYQYWTPTLVFSSIVVAAAMVLLLRKPLSAPGARASARQRGDEGTSPEPAFPTPPLLAGATKENAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTC2</accession>
    <name>A0A7U8TTC2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416822.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTC2"/>
    <dbReference type="GeneID" id="45427188"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="9">
        <location>
            <begin position="10"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="10">
        <location>
            <begin position="302"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="8">
        <location>
            <begin position="626"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD14927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="700" mass="75604" checksum="60A1B7520855C81C" modified="2021-06-02" version="1">MSIASDPLIAGLDDQQREAVLAPRGPVCVLAGAGTGKTRTITHRIASLVASGHVAAGQVLAVTFTQRAAGEMRSRLRALDAAARTGSGVGAVQALTFHAAAYRQLRYFWSRVIADTGWQLLDSKFAVVARAASRTRLHASTDDVRDLAGEIEWAKASLIGPEEYVTAVAAARRDPPLDAAQIAAVYSEYEALKARGDGVTLLDFDDLLLHTAAAIENDAAVAEEFQDRYRCFVVDEYQDVTPLQQRVLSAWLGDRDDLTVVGDANQTIYSFTGASPRFLLDFSRRFPDAAVVRLERDYRSTPQVVSLANRVIAAARGRVAGSKLRLSGQREPGPVPSFHEHSDEPAEAATVAASIARLIASGTPPSEVAILYRVNAQSEVYEEALTQAGIAYQVRGGEGFFNRQEIKQALLALQRVSERDTDAALSDVVRAVLAPLGLTAQPPVGTRARERWEALTALAELVDDELAQRPALQLPGLLAELRRRAEARHPPVVQGVTLASLHAAKGLEWDAVFLVGLADGTLPISHALAHGPNSEPVEEERRLLYVGITRARVHLALSWALSRSPGGRQSRKPSRFLNGIAPQTRADPVPGTSRRNRGAAARCRICNNELNTSAAVMLRRCETCAADVDEELLLQLKSWRLSTAKEQNVPAYVVFTDNTLIAIAELLPTDDAALIAIPGIGARKLEQYGSDVLQLVRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTC5</accession>
    <name>A0A7U8TTC5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03999</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 65 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900047.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTC5"/>
    <dbReference type="GeneID" id="45427397"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005194">
        <property type="entry name" value="Glyco_hydro_65_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005195">
        <property type="entry name" value="Glyco_hydro_65_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005196">
        <property type="entry name" value="Glyco_hydro_65_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037018">
        <property type="entry name" value="Glyco_hydro_65_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017045">
        <property type="entry name" value="Malt_Pase/Glycosyl_Hdrlase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03633">
        <property type="entry name" value="Glyco_hydro_65C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03632">
        <property type="entry name" value="Glyco_hydro_65m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03636">
        <property type="entry name" value="Glyco_hydro_65N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036289">
        <property type="entry name" value="Glycosyl_hydrolase_malt_phosph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="SSF74650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_65N" evidence="9">
        <location>
            <begin position="16"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65m" evidence="7">
        <location>
            <begin position="327"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_65C" evidence="8">
        <location>
            <begin position="698"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="590"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036289-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD15101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="786" mass="87316" checksum="73CB5E78DAD10AE6" modified="2021-06-02" version="1">MITEDAFPVEPWQVRETKLNLNLLAQSESLFALSNGHIGLRGNLDEGEPFGLPGTYLNSFYEIRPLPYAEAGYGYPEAGQTVVDVTNGKIFRLLVGDEPFDVRYGELISHERILDLRAGTLTRRAHWRSPAGKQVKVTSTRLVSLAHRSVAAIEYVVEAIEEFVRVTVQSELVTNEDVPETSADPRVSAILDRPLQAVEHERTERGALLMHRTRASALMMAAGMEHEVEVPGRVEITTDARPDLARTTVICGLRPGQKLRIVKYLAYGWSSLRSRPALRDQAAGALHGARYSGWQGLLDAQRAYLDDFWDSADVEVEGDPECQQAVRFGLFHLLQASARAERRAIPSKGLTGTGYDGHAFWDTEGFVLPVLTYTAPHAVADALRWRASTLDLAKERAAELGLEGAAFPWRTIRGQESSAYWPAGTAAWHINADIAMAFERYRIVTGDGSLEEECGLAVLIETARLWLSLGHHDRHGVWHLDGVTGPDEYTAVVRDNVFTNLMAAHNLHTAADACLRHPEAAEAMGVTTEEMAAWRDAADAANIPYDEELGVHQQCEGFTTLAEWDFEANTTYPLLLHEAYVRLYPAQVIKQADLVLAMQWQSHAFTPEQKARNVDYYERRMVRDSSLSACTQAVMCAEVGHLELAHDYAYEAALIDLRDLHRNTRDGLHMASLAGAWTALVVGFGGLRDDEGILSIDPQLPDGISRLRFRLRWRGFRLIVDANHTDVTFILGDGPGTQLTMRHAGQDLTLHTDTPSTIAVRTRKPLLPPPPQPPGREPVHRRALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTG0</accession>
    <name>A0A7U8TTG0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6036 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416066.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045792">
        <property type="entry name" value="DUF6036"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19502">
        <property type="entry name" value="DUF6036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6036" evidence="2">
        <location>
            <begin position="267"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="412" mass="45820" checksum="4A4773DE69C1E819" modified="2021-06-02" version="1">MTPHYRQAAASRLDTHRTQKLRSQTNGGKDRHQLTYEQFARMLTLMGPSDLWTVERAARHWGVSASRARAILSSRHIHRVSGYPAQAIKAVTLRQGARTDLKTANHLVPAAQAFTMAETGAAIGETEDERARLRIFFEFLRGADETGTSALDLIVDEPALIGEHRFDALLAAAAEYISARWGRPGPLWSVSIERFLDTAWWVSDLPSARAFAAVWTPAPFRRRGIYLDRHDLTSDGVCVMPEPVFNRTELQRAFTALAAKLERRGVVGQVHVVGGAAMLLAYNSRVTTRDIDALFSTDGPMLEAIREVADEMGWPRTWLNNQASGYVSRTPGEGAPVFDHPFLHVVATPAQHLLAMKVVAARGVRDGEDIRLLLDRLRITSAAGVWEIVARYFPAETITDRSRLLVEDLLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTG5</accession>
    <name>A0A7U8TTG5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663495">
        <property type="protein sequence ID" value="EFD15161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="69" mass="6284" checksum="5BD4244A86A884AE" modified="2021-06-02" version="1">GWPGRHWRRPGLRRLTGGDGGDGGDGGNGGNSGAKAGGAGGKGQAGQPNSGTEPGFGGDGGLGGAGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTJ1</accession>
    <name>A0A7U8TTJ1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899929.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTJ1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022171">
        <property type="entry name" value="PPE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12484">
        <property type="entry name" value="PPE-SVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-SVP" evidence="3">
        <location>
            <begin position="293"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="391" mass="38586" checksum="80F5EEDE9D80ADF1" modified="2021-06-02" version="1">MVLGFSWLPPEINSARMFAGAGSGPLFAAASAWEGLAADLWASASSFESVLAALTTGPWTGPASMSMAAAASPYVGWLSTVASQAQLAAIQARAAATAFEAALAATVHPTAVTANRVSLASLIAANVLGQNTPAIAATEFDYLEMWAQDVAAMVGYHAGAKSVAATLAPFSLPPVSLAGLAAQVGTQVAGMATTASAAVTPVVEGAMASVPTVMSGMQSLVSQLPLQHASMLFLPVRILTSPITTLASMARESATRLGPPAGGLAAANTPNPSGAAIPAFKPLGGRELGAGMSAGLGQAQLVGSMSVPPTWQGSIPISMASSAMSGLGVPPNPVALTQAAGAAGGGMPMMLMPMSISGAGAGMPGGLMDRDGAGWHVTQARLTVIPRTGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TU50</accession>
    <name>A0A7U8TU50_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417749.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427354"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021385">
        <property type="entry name" value="DUF3017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11222">
        <property type="entry name" value="DUF3017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="97" mass="10142" checksum="01706523CDA4D4C5" modified="2021-06-02" version="1">MTVRAVFRRTVGAQWPILLVGSIFAVGFVLAGANFWRRGALLIGIGVGVAAVLRLVLSEERAGLLVVRSKGIDFVTTVTVAAAMVYIASTIDPLGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y219</accession>
    <name>A0A7U8Y219_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="330" mass="34662" checksum="C3210E1A1302DC31" modified="2021-06-02" version="1">MPAIPFQGEARAGRRPGRPRRCPAGVVRCRPRSMGHVRPGFSPRLGSHRTLRPRWPPYAAASRGLTSGTSRWGWPRLGFGVVTAPTRWTLADGRELLFFSLPGPRTSGTAAERVARHAQAQTFAGDIRQRAIQLVVSEQEVASKITAATAGIATTTFPETPSIDDTIIGNDNRDTGVRLVDVKQDGGTSPPPPFAPWDTPDGTPPPGTGLSPTLQQMILGGDPANLTGQGLADNVQRFVQSLPANDPNTAWLRGQVADLQAHVADIEYARTHCSTNDWIDRTAQFASGAIVFSIGVLTAETGAGVVAAAAGGVGAATAGVSLLQCLVGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y297</accession>
    <name>A0A7U8Y297_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404368.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424803"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019238">
        <property type="entry name" value="AbiEi_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016600">
        <property type="entry name" value="UCP012611"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09952">
        <property type="entry name" value="AbiEi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012611">
        <property type="entry name" value="UCP012611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="342" mass="36896" checksum="B76CD42DD697DD8C" modified="2021-06-02" version="1">MDQIGADLAEAVERHLTEYGVRVLGGLSALNSAHPESLDLEIDAHPLTITALYLPHLSATAALQAWDTAGAGSPLLVVGPRLHPSSAETLRARGLWYIDGAGNAYLRHQGGLLIDVRGRRSAVSAQPGTLGDGLHSDGPRNPFTPKRAQVVCVLLDAPQLVDAPLRAIAASAGVSVGMAKETMDTLRTTGFFEHLGSRRRLVRTDELLDLWAAAYPGGLGRANKLLVASGDIHTWSAPDGLAVAVSGEQALPDEIRNPESLMLYVDTPAPGLPADLLIHNRWHRDPHGSIVIRKLFWRNLPDEQPGLAPTALIYADLLASREPRQVEVAHLMRRQDERLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2A0</accession>
    <name>A0A7U8Y2A0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2A0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="275" mass="29219" checksum="F6C10991B78AE69D" modified="2021-06-02" version="1">MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDVDKPGLRQAVNHLRAEGFDVHGVMCDVRHREEVTHLADEAFRLLGHVDVVFSNAGIVVGGPIVEMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTGGHVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADGIGVSVLCPMVVETNLVANSERIRGAACAQSSTTGSPGPLPLQDDNLGVDDIAQLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2L0</accession>
    <name>A0A7U8Y2L0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02976</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404349.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2L0"/>
    <dbReference type="GeneID" id="45424793"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="301" mass="33416" checksum="5F6C68208D1E6199" modified="2021-06-02" version="1">MVRADRDRWDLATSVGATATMVAAQRALAADPRYALIDDPYAAPLVRAVGMDVYTRLVDWQIPVEGDSEFDPQRMATGMACRTRFFDQFFLDATHSGIGQFVILASGLDARAYRLAWPVGSIVYEVDMPEVIEFKTATLSDLGAEPATERRTVAVDLRDDWATALQTAGFDPKVPAAWSAEGLLVYLPVEAQDALFDNITALSAPGSRLAFEFVPDTAIFADERWRNYHNRMSELGFDIDLNELVYHGQRGHVLDYLTRDGWQTSALTVTQLYEANGFAYPDDELATAFADLTYSSATLMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2M4</accession>
    <name>A0A7U8Y2M4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403376.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2M4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="102" mass="11320" checksum="6EB2F795CAAE1E11" modified="2021-06-02" version="1">MRRGELWFAATPGGDRPVLVLTRDPVADRIGAVVVVALTRTRRGLVSELELTAVENRVPSDCVVNFDNIHTLPRTAFRRRITRLSPARLHEACQTLRASTGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2P0</accession>
    <name>A0A7U8Y2P0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404412.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2P0"/>
    <dbReference type="GeneID" id="45424820"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="147" mass="16346" checksum="D8B55F6B86293E07" modified="2021-06-02" version="1">MAIKESRDIVIEASPEEILDVIADFEAMTEWSPAHQSVEILETGDDGRPSKVKMKVKTAGITDEQVVAYSWTDRSVRWTLVSSTQQRSQDGKYELTPKGDNTLVQFEITVDPQVPLPGFVLKRAIKGTIDTATEALRSQVLKVKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Q8</accession>
    <name>A0A7U8Y2Q8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404726.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Q8"/>
    <dbReference type="GeneID" id="45424873"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="144" mass="15754" checksum="852217DB6D0D4E4A" modified="2021-06-02" version="1">MAKLSGSIDVPLPPEEAWMHASDLTRYREWLTIHKVWRSKLPEVLEKGTVVESYVEVKGMPNRIKWTIVRYKPPEGMTLNGDGVGGVKVKLIAKVAPKEHGSVVSFDVHLGGPALLGPIGMIVAAALRADIRESLQNFVTVFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2R3</accession>
    <name>A0A7U8Y2R3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="319" mass="34156" checksum="7A25541525707FB9" modified="2021-06-02" version="1">MHRPPWLAQLRRRLRIGVQLGSRVVLEQGRQPRDVYVIGVLVGDQDRGQTGDSLEAVRESTGIEEQAGLTELSEEAGMAEMRELHVYDCALMGAFPMRLILATMLVAGRLLATLMAAPSAQAEPETCPPICDQIPATAWISTHAVPLNSQYRWPAMAGAAVAVTRATPRFGFEQVCATPAFPHDSRDWAVAGRVTVVHPDGQWQLQAQVLHWRGDTARGGQIAASVFGTAVAALRACQLGAPLQSPSVTDDEPTRMAAVISGPVIMHTYLVAHVSSSTISELTLWSSGPPQVPWPTVADSAVLDALTAPLCEAYIGSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Y9</accession>
    <name>A0A7U8Y2Y9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mutator protein mutT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03336</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406084.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Y9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="141" mass="15160" checksum="6BA8276A1D38413E" modified="2021-06-02" version="1">MLNQIVVAGAIVRGCTVLVAQRVRPPELAGRWELPGGKVAAGETERAALARELAEELGLEVADLAVGDRVGDDIALNGTTTLRAYRVHLLGGEPRARDHRALCWVTAAELHDVDWVPADRGWIADLARTLNGSAADVHRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y319</accession>
    <name>A0A7U8Y319_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein lprC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900308.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425247"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031438231" evidence="1">
        <location>
            <begin position="35"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="180" mass="18871" checksum="71DEB7D39E91D7DD" modified="2021-06-02" version="1">MRRVLVGAAALITALLVLTGCTKSISGTAVKAGGAGVPRNNNSQERYPNLLKECEVLTTDILAKTVGADPLDIQSTFVGAICRWQAANPAGLIDITRFWFEQGSLSNERKVAEGLKYQVETRAIQGVDSIVMRTGDPNGACGVASDAAGVVGWWVNPQAPGIDACGQAIKLMELTLATNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y335</accession>
    <name>A0A7U8Y335_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406182.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y335"/>
    <dbReference type="GeneID" id="45425148"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018309">
        <property type="entry name" value="Tscrpt_reg_PadR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10400">
        <property type="entry name" value="Vir_act_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Vir_act_alpha_C" evidence="2">
        <location>
            <begin position="105"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="189" mass="21077" checksum="48E8F1B70DEA7F02" modified="2021-06-02" version="1">MALPHAILVSLCEQASSGYELARRFDRSIGYFWTATHQQIYRTLRVMENNNWVRATTVLQHGRPDKKVYAISDSGRAELARWIAEPLSPTRPGRGSALTDSSTRDIAVKLRGAGYGDVAALYTQVTALRAERVKSLDTYRGIEKRTFADPSALDGAALHQYLVLRGGIRAEESAIDWLDEVAEALQEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y344</accession>
    <name>A0A7U8Y344_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406241.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y344"/>
    <dbReference type="GeneID" id="45425177"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="3">
        <location>
            <begin position="42"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="318" mass="33046" checksum="918057B69AAA8E65" modified="2021-06-02" version="1">MRSTPPASAGRSTPPALAGHSTPPALAGHSTLCGRPVAGDRALIMAIVNRTPDSFYDKGATFSDAAARDAVHRAVADGADVIDVGGVKAGPGERVDVDTEITRLVPFIEWLRGAYPDQLISVDTWRAQVAKAACAAGADLINDTWGGVDPAMPEVAAEFGAGLVCAHTGGALPRTRPFRVSYGTTTRGVVDAVISQVTAAAERAVAAGVAREKVLIDPAHDFGKNTFHGLLLLRHVADLVMTGWPVLMALSNKDVVGETLGVDLTERLEGTLAATALAAAAGARMFRVHEVAATRRVLEMVASIQGVRPPTRTVRGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y347</accession>
    <name>A0A7U8Y347_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407054.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425339"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="78" mass="8773" checksum="5ACF819F57E4AE15" modified="2021-06-02" version="1">MMALMNEIDLYEHKTPLPISPTSEGTPMTETHFRQTLYECAVKLRELAYTLPQGVGEHALLRMSEQMIVTAGQVAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y396</accession>
    <name>A0A7U8Y396_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898852.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y396"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="49"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="212" mass="22815" checksum="43A031E73FF9D3A4" modified="2021-06-02" version="1">MPGIDFDALYRGESPGEGLPPITTPPWDTKAPKDNVIGWHTGGWVHGDVLDIGCGLGDNAIYLARNGYQVTGLDISPTALTTAKRRASDAGVDVKFAVGDATKLTGYTGAFDTVIDCGMFHCLDDDGKRSYAASVHRATRPGATLLLSCFSNAMPPDEEWPRSTVSEQTLRDVLGGAGWDIESLEPATVRRELDGTEVEMAFWNVRAQRRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y413</accession>
    <name>A0A7U8Y413_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="7">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gpsA</name>
        <name evidence="16" type="ORF">TBLG_02692</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 13">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 11">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 7 13" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_Gly3P_dh_N" evidence="14">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_Gly3P_dh_C" evidence="15">
        <location>
            <begin position="184"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="259"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFD12108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="332" mass="35245" checksum="547C4D8F29ADF97D" modified="2021-06-02" version="1">MAANKREPKVVVLGGGSWGTTVASICARRGPTLQWVRSAVTAQDINDNHRNSRYLGNDVVLSDTLRATTDFTEAANCADVVVMGVPSHGFRGVLVELSKELRPWVPVVSLVKGLEQGTNMRMSQIIEEVLPGHPAGILAGPNIAREVAEGYAAAAVLAMPDQHLATRLSAMFRTRRFRVYTTDDVVGVETAGALKNVFAIAVGMGYSLGIGENTRALVIARALREMTKLGVAMGGKSETFPGLAGLGDLIVTCTSQRSRNRHVGEQLGAGKPIDEIIASMSQVAEGVKAAGVVMEFANEFGLNMPIAREVDAVINHGSTVEQAYRGLIAEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y433</accession>
    <name>A0A7U8Y433_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="88" mass="9623" checksum="EF551C33C39A2A38" modified="2021-06-02" version="1">MRIPGNRQCLLVQVLRQVDGSAHRLILTSLHRDARADAHRYSNGTDHAGRAADEPAETAHEPCWVAARGLASQASRAMSATYRPSSFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y438</accession>
    <name>A0A7U8Y438_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase echA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403259.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y438"/>
    <dbReference type="GeneID" id="45424587"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="231" mass="24355" checksum="1AE1D51006CD0922" modified="2021-06-02" version="1">MSDPVSYTRKDSIAVISMDDGKVNALGPAMQQALNAAIDNADRDDVGALVITGNGRVFSGGFDLKILTSGEVQPAIDMLRGGFELAYRLLSYPKPVVMACTGHAIAMGAFLLSCGDHRVAAHAYNIQANEVAIGMTIPYAALEIMKLRLTRSAYQQATGLAKTFFGETALAAGFIDEIALPEVVVSRAEEAAREFAGLNQHAHAATKLRSRADALTAIRAGIDGIAAEFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4M2</accession>
    <name>A0A7U8Y4M2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="135" mass="14642" checksum="0FF75438393F9598" modified="2021-06-02" version="1">MGYELHRAGKSAAKLRVAACRSAASAKRSSGGQRKAPPNNALARGIGVNRPRPSNLEETVRFYRDLVGMLDQTFAESYGSNGAIFGLPSSSLTLEIVETDHHEQLCRYCSDKRGQQAALTGLQEVATQPVEQRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4R8</accession>
    <name>A0A7U8Y4R8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4R8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="129" mass="14136" checksum="9F0941B135B6926F" modified="2021-06-02" version="1">MDCCEERGVARHKGLSQVGTPGCPRWSQAVSCRCSAYREAAVTAVQMPLTPGYGETPLPHDELAALLPEVVEVLDKPITRADVYDLEQGLQDQVFDLLMPTAVEGSLSLDELLSDHFVRDLHARMFGPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4S1</accession>
    <name>A0A7U8Y4S1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406628.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="104" mass="10713" checksum="B6C0996DF9699208" modified="2021-06-02" version="1">MLALHGLSEGVSGSGGSGGRWGAGEVLEGARIGVIADGVSCFPTKADCRRIRGVPVFDGYTRMVARLMGSLAVLRSVSIPKGYRDFGFGSLRAVAPKNCPDVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4T2</accession>
    <name>A0A7U8Y4T2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="381" mass="30862" checksum="3B14B97AABF878DD" modified="2021-06-02" version="1">MGYRRGRWRRRAGNGRSGPVNVAGSAGGNGGAGGAAGLFGDAGAGGNGGKGGAGGAAFSINFTAGDGGAGGAGGSGGHALLWGAGGAGGNGGSGGTGGAGGSTAGAGGNGGAGGGGGTGGLLFGNGGAGGHGAAAGNGLAAGNGVSSSGGGGAGGTGGAGGDGGAGGAGGNARLWGVGGAGGAGGKGGSGLSGNANGGAGGDSGRGGTGGAGGEGGAAGLLVGTGGHGGDGGAGGQGATAGAGGAGANGVSSTNGGGTGGNGGIGGTGGSGGAGGNAGLLGVGGAGGHGASGGAGDRGGAGGTGFISSDGGAGGDGGDGGNGGSGGAGGTGGLLFGAGGNGGPGGSGGAADIGGNGGAGNGGGTDGNGGKWRVRRRRRQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4Z8</accession>
    <name>A0A7U8Y4Z8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="17 18">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="17">ATP synthase subunit b</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="17">ATP synthase F(0) sector subunit b</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="17">ATPase subunit I</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="17">F-type ATPase subunit b</fullName>
                <shortName evidence="17">F-ATPase subunit b</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="18">ATP synthase subunit delta</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="18">ATP synthase F(1) sector subunit delta</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="18">F-type ATPase subunit delta</fullName>
                <shortName evidence="18">F-ATPase subunit delta</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="18" type="primary">atpH</name>
        <name evidence="17" type="synonym">atpF</name>
        <name evidence="20" type="ORF">TBLG_03489</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="15 17">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="14">This fusion protein includes a component of the F(0) channel (subunit b) and of the F(1) subunit (subunit delta). Two copies of subunit b and one of delta together form the peripheral 'stator' stalk which links F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="18">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16 17">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Cell membrane</location>
            <topology evidence="18">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 17">Cell membrane</location>
            <topology evidence="1 17">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ATPase B chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the ATPase delta chain family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406697.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4Z8"/>
    <dbReference type="GeneID" id="45425281"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005864">
        <property type="entry name" value="ATP_synth_F0_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01144">
        <property type="entry name" value="ATP_synt_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 17" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="17" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 17" id="KW-0138">CF(0)</keyword>
    <keyword evidence="18" id="KW-0139">CF(1)</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 17" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="48"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFD12905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="446" mass="48806" checksum="AF07F26E38B78315" modified="2021-06-02" version="1">MSTFIGQLFGFAVIVYLVWRFIVPLVGRLMSARQDTVRQQLADAAAAADRLAEASQAHTKALEDAKSEAHRVVEEARTDAERIAEQLEAQADVEAERIKMQGARQVDLIRAQLTRQLRLELGHESVRQARELVRNHVADQAQQSATVDRFLDQLDAMAPATADVDYPLLAKMRSASRRALTSLVDWFGTMAQDLDHQGLTTLAGELVSVARLLDREAVVTRYLTVPAEDATPRIRLIERLVSGKVGAPTLEVLRTAVSKRWSANSDLIDAIEHVSRQALLELAERAGQVDEVEDQLFRFSRILDVQPRLAILLGDCAVPAEGRVRLLRKVLERADSTVNPVVVALLSHTVELLRGQAVEEAVLFLAEVAVARRGEIVAQVGAAAELSDAQRTRLTEVLSRIYGHPVTVQLHIDAALLGGLSIAVGDEVIDGTLSSRLAAAEARLPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7J1</accession>
    <name>A0A7U8Y7J1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="14" type="ORF">TBLG_03898</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417079.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7J1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="13">
        <location>
            <begin position="26"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD15000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="89" mass="10157" checksum="04D4D99C01D6D9BD" modified="2021-06-02" version="1">MVPEAPAPFEEPLPPEATDQWQDRALCAQTDPEAFFPEKGGSTREAKKICMGCEVRHECLEYALAHDERFGIWGGLSERERRRLKRGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7L9</accession>
    <name>A0A7U8Y7L9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418008.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7L9"/>
    <dbReference type="GeneID" id="45427408"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035165">
        <property type="entry name" value="DUF5319"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17252">
        <property type="entry name" value="DUF5319"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="136" mass="15302" checksum="FA7F2660F99FDF62" modified="2021-06-02" version="1">MRDHLPPGLPPDPFADDPCDPSAALEAVEPGQPLDQQERMAVEADLADLAVYEALLAHKGIRGLVVCCDECQQDHYHDWDMLRSNLLQLLIDGTVRPHEPAYDPEPDSYVTWDYCRGYADASLNEAAPDADRFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7R3</accession>
    <name>A0A7U8Y7R3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF222 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF222" evidence="2">
        <location>
            <begin position="38"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="222" mass="24504" checksum="C406444AF75EACEF" modified="2021-06-02" version="1">MGSGSRERIVEVFDALDAELDRLDEVSFEVLTTPERLRSLERLECLVRRLPAVGHALINQLDAQASEEELGGTLCCALANRLRITKPDAARRIADAADLGPRRALTGEPLAPQLTATATAQRQGLIGEAHIKVIRALFRPPARRGGCVHPPGRRSRPGRQSRSISSRRAGPLRPAGHGLATPRRRPHRHRTRPQTRHHPEQPAIRRHVTAKWLPDPPSAGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y804</accession>
    <name>A0A7U8Y804_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the hydrocarbon hydroxylating system, which transfers electrons from NADH to rubredoxin reductase and then through rubredoxin to alkane 1 monooxygenase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417044.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y804"/>
    <dbReference type="GeneID" id="45427244"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="60" mass="6797" checksum="E0FBA3651C8BCC37" modified="2021-06-02" version="1">MNDYKLFRCIQCGFEYDEALGWPEDGIAAGTRWDDIPDDWSCPDCGAAKSDFEMVEVARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y822</accession>
    <name>A0A7U8Y822_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RES domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y822"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014914">
        <property type="entry name" value="RES_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08808">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00953">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RES" evidence="1">
        <location>
            <begin position="33"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="206" mass="22944" checksum="E487703890AF144A" modified="2021-06-02" version="1">MKLADAIATAPRRTLKGTYWHQGPTRHPVTSCADPARGPGRYHRTGEPGVWYASNKEQGAWAELFRHFVDDGVDPFEVRRRVGRVAVTLQVLDLTDERTRSHLGVDETDLLSDDYTTTQAIAAARDANFDAVLAPAAALPGCQTLAVFVHALPNIEPERSEVRQPPPRLANLLPLIRPHEHMPDSVRRLLATLTRAGAEAIRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y842</accession>
    <name>A0A7U8Y842_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methanethiol S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.334</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methylation of methanethiol (MeSH) to yield dimethylsulphide (DMS).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:50428"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:17437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.334"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nurim family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.334" evidence="5"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416945.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y842"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033580">
        <property type="entry name" value="Nurim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040">
        <property type="entry name" value="PTHR31040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD14973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="244" mass="28031" checksum="4653BEF3A8FD540B" modified="2021-06-02" version="1">MKRYLTIIYGAASYLVFLVAFGYAIGFVGDVVVPRTVDHAIAAPIGQAVVVNLVLLGVFAVQHSVMARQGFKRWWTRFVPPSIERSTYVLLASVALLLLYWQWRTMPAVIWDVRQPAGRVALWALFWLGWATVLTSTFMINHFELFGLRQVYLAWRGKPYTEIGFQAHLLYRWVRHPIMLGFVVAFWATPMMTAGHLLFAIGATGYILVALQFEERDLLAALGDQYRDYRREVSMLLPWPHRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y856</accession>
    <name>A0A7U8Y856_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04052</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003422266.1">
        <property type="nucleotide sequence ID" value="NZ_KK338640.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="14"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="163" mass="17671" checksum="4DA681085779EC0B" modified="2021-06-02" version="1">MTAENPGRSRRTLVGIDAAITACHHIAIRDDVGARSIRFSVEPTLAGLRTLTDKLSGYDDIDATVEPTSMTWLPLTIAVENAGDTMHMAGARHCARLRGAIVGKSKSDVIDAEVLTRASEVFDLTPLTLPTPAQLALRRSVIRRAGAVIDANRSWRRLMSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y881</accession>
    <name>A0A7U8Y881_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418774.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y881"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="168" mass="18568" checksum="D57D3C0C4F1D4C40" modified="2021-06-02" version="1">MRPVDEQWIEILRIQALCARYCLTIDTQDGEGWAGCFTEDGAFEFDGWVIRGRPALREYADAHARVVRGRHLTTDLLYEVDGDVATGRSASVVTLATAAGYKILGSGEYQDRLIKQDGQWRIAYRRLRNDRLVSDPSVAVNVADADVAAVVGHLLAAARRLGTQMSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y890</accession>
    <name>A0A7U8Y890_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_04021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="124" mass="13219" checksum="589B403262A7CA53" modified="2021-06-02" version="1">MGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETVRFGLPKQVRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y8B6</accession>
    <name>A0A7U8Y8B6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418298.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y8B6"/>
    <dbReference type="GeneID" id="45427428"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="280" mass="29241" checksum="D5DD102ACD7C01D0" modified="2021-06-02" version="1">MPRIRKLVAALHRRGPHRVLRGDLAFAGLPGVVYTPEAGLHLPGVAFGHDWLTGTSRYSGLLEHLASWGIVAAAPDSERGLAPSVLNLAFDLGVALDIVAGVRLGPGKISVHPAKLGLVGHGFGGSAAVFAAAGLTGTHVKSVAAIFPTVTNPAAEQPAATLDVPGLILTAPGDPKTLTSNALGLSRAWDKATLRIVSKARAGGLVEGRRLTKVLGLPGPHRRTQRSVRALLTGYLLYTLGGDKTYRRFADPDLQLPKTDPIDPEAPPITPGEKIVTLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA92</accession>
    <name>A0A7U8YA92_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418042.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA92"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="168" mass="18214" checksum="625F08C7BE52CCA0" modified="2021-06-02" version="1">MSREGIRRRPKARAGLTGGGTATLPRVEDTLTLGSRLGEQLCAGDVVVLSGPLGAGKTVLAKGIAMAMDVEGPITSPTFVLARMHRPRRPGTPAMVHVDVYRLLDHNSADLLSELDSLDLDTDLEDAVVVVEWGEGLAERLSQRHLDVRLERVSHSDTRIATWSWGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAA3</accession>
    <name>A0A7U8YAA3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900050.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAA3"/>
    <dbReference type="GeneID" id="45427402"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD" evidence="4">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="295" mass="32579" checksum="213EB93DEF58F2A6" modified="2021-06-02" version="1">MTDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLAFAGLLGTPIGHPAAIALADDAPIITPINSEFGKANRWHTDVTFAANYPAASVLRAVSLPSYGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTTKPLTAAQRAFRQVFEKPDFRTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVLQRRITMPENTIRWNWAPGDVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQASRVISGAPMEIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAA6</accession>
    <name>A0A7U8YAA6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">1-deoxy-D-xylulose-5-phosphate synthase</fullName>
            <ecNumber evidence="6">2.2.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_04022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="6"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transket_pyr" evidence="11">
        <location>
            <begin position="212"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD15124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="536" mass="57234" checksum="8D4ADF333F9BB7BD" modified="2021-06-02" version="1">MFDTGHQTYPHKLLTGRGKDFATLRQADGLSGYPNRHESPHDWVENSHASVSLAWVDGIAKALALQGQCDRRVIAVIGDGALTGGVAWEGLNNLGAATRPVIVVLNDNGRSYDPTAGALAAHLEELRVGTPRGPNLFENMGFTYIGPVDGHNIPDTCAVLRKAAAAARPVVVHAVTSKGRGYPPAEADERDHMHACGVVDIATGLASTPSQRSWTDVFEDEIARIADDRSDVVGLTAAMRLPTGLGALSRRYPHRVFDSGIAEQHLLASAAGLAAAGTHPVVAVYSTFLHRAFDQLLFDIGLHRLPVTLVLDRAGVTGPDGPSHHGLWDLALLACVPGFQIACPRDAPRLRQQLRTAIATAAPTAVRFPKGAPGEPITAEHTIGGLDVLHTPPPHWRPDVLLVAVGAMSRPRMDAARCLSEEQIGVTVVDPQWVWPISPALTELAGRHRITVCVEDAIADVGIGAHLSHHIGRTHPRTRTYTLGLPPAYIPHASRDHILSSHGLTGPAIRIRCKSLLNALHEVPGPEDHPDSGDSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAC8</accession>
    <name>A0A7U8YAC8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAC8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="37"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="297" mass="31776" checksum="A4B225803419B681" modified="2021-06-02" version="1">MPSPSTTGHHAACGTGGTGFSVGSMRSPIRVGSGEPVLLLHPFLMSQTVWEKVAQQLADTGRFEVFAPTMAGHNGGPASGTRFLSSAVLADHVERQLDELGWETSHIVGNSLGGWVAFELERRGRARSVTGIAPAGGWTRWSPVKFEVIAKFIAGAPILAVAHILGQRALRLPFSRLLATLPISATPDGVSERELSGIIDDAAHCPAYFQLLVKALVLPGLQELEHTAVPSHVVLCEQDRVVPPSRFSRHFTDSLPAGHRLTVLDGVGHVPMFEAPGRITELITSFIEECCPHVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAF0</accession>
    <name>A0A7U8YAF0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_04153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418993.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAF0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="63" mass="6904" checksum="2C29D2CE701421E0" modified="2021-06-02" version="1">MRVIVDRDRCEGNAVCLGIAPDIFDLDDEDYAVVKTDPIPVDQEDLAEQAIAECPRAALSRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF04</accession>
    <name>A0A7U8TF04_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase galE3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="346" mass="36193" checksum="25CAA2CFFC9149AF" modified="2021-06-02" version="1">MRVLLTGAAGFIGSRVDAALRAAGHDVVGVDALLAAAHGPNPVLPPGCQRVDVRDASALAPLLAGVDLVCHQAAMVGAGVNAADAPAYGGHNDFATTVLLAQMFAAGVRRLVLASSMVVYGQGRYDCPQHGPVDPLPRRRADLDNGVFEHRCPGCGEPVIWQLVDEDAPLRPRSLYAASKTAQEHYALAWSEASGGSVVALRYHNVYGPGMPRDTPYSGVAAIFRSAVEKGKPPKVFEDGGQMRDFVHVDDVAAANLAAVHLGEADRDGFTAVNVCSGRPISILQVATAICDARGGSMSPAITGHYRSGDVRHIVADPARAARVLGFRAAVDPGEGLREFAFAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF89</accession>
    <name>A0A7U8TF89_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032568">
        <property type="entry name" value="DUF4926"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16277">
        <property type="entry name" value="DUF4926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="127" mass="13639" checksum="9045BD341E270B82" modified="2021-06-02" version="1">MPDRPQHPTASRQSSMVSWNHGAAGWLHCVQCGSATNPTACLDWLPPIHARSGPMYAEHDVVVLTRDVPDKSLIAGDVGAVVGRYAAGGYEVDFTAANGCTVAVVTLAGDDIRPRRRREIPHVREVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFA8</accession>
    <name>A0A7U8TFA8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase</fullName>
            <shortName evidence="3">SEPHCHC synthase</shortName>
            <ecNumber evidence="3">2.2.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthesis protein MenD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">menD</name>
        <name evidence="5" type="ORF">TBLG_02683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="ChEBI" id="CHEBI:58818"/>
            <dbReference type="EC" id="2.2.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="3">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPP enzyme family. MenD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.9" evidence="3"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402927.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFA8"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="UniPathway" id="UPA01057">
        <property type="reaction ID" value="UER00164"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070204">
        <property type="term" value="F:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01659">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004433">
        <property type="entry name" value="MenaQ_synth_MenD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42916">
        <property type="entry name" value="PTHR42916"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004983">
        <property type="entry name" value="MenD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00173">
        <property type="entry name" value="menD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 3" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="554" mass="57836" checksum="879423AAB00F36A5" modified="2021-06-02" version="1">MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGYLAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTMEQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIPLREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNLAALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTTGPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAAAVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEGAHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQGDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADRSSLRQLHAAIKAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFD6</accession>
    <name>A0A7U8TFD6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403474.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424651"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="84" mass="8784" checksum="7000B32AD4102B5E" modified="2021-06-02" version="1">MLGWTVKPGRVADGWQAPGVHLMARCSGPQPASERRADMDGGDIDAAVARVRAAGALAEPSRQPDDMSAECADDQGARCHLGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFK2</accession>
    <name>A0A7U8TFK2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403957.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="206" mass="21572" checksum="F4B619C96D6DDA3C" modified="2021-06-02" version="1">MRSRFLPYATTPGRLLAQLISDITVAVWTTLWMLVGLAVHDAISIIGEAGRQIEIGSHGIAGNLAAAGQDAQRIPVVGDALSNPITAASQAALDIAGAGHNLDTTAGWLAVVLALAVAATPILAVAMPWLFLRLRFCRRKWTVTTLAATPAGRQLLALRALANRPPGKLAAVSTDPVGAWRREDPATMRALAALELRAAGIPLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFL2</accession>
    <name>A0A7U8TFL2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurS</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit III</fullName>
            <shortName evidence="5">FGAR amidotransferase III</shortName>
            <shortName evidence="5">FGAR-AT III</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purS</name>
        <name evidence="6" type="ORF">TBLG_02935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PurS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403993.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFL2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01926">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34696">
        <property type="entry name" value="PTHR34696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00302">
        <property type="entry name" value="TIGR00302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="79" mass="8622" checksum="C9D0B7C971AE1CCA" modified="2021-06-02" version="1">MARVVVHVMPKAEILDPQGQAIVGALGRLGHLGISDVRQGKRFELEVDDTVDDTTLAEIAESLLANTVIEDWTISRDPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFL9</accession>
    <name>A0A7U8TFL9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">29 kDa antigen cfp29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the encapsulin family. Family 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404092.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFL9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019254">
        <property type="entry name" value="CFP29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="265" mass="28830" checksum="00E7E96904D3B33A" modified="2021-06-02" version="1">MNNLYRDLAPVTEAAWAEIELEAARTFKRHIAGRRVVDVSDPGGPVTAAVSTGRLIDVKAPTNGVIAHLRASKPLVRLRVPFTLSRNEIDDVERGSKDSDWEPVKEAAKKLAFVEDRTIFEGYSAASIEGIRSASSNPALTLPEDPREIPDVISQALSELRLAGVDGPYSVLLSADVYTKVSETSDHGYPIREHLNRLVDGDIIWAPAIDGAFVLTTRGGDFDLQLGTDVAIGYASHDTDTVRLYLQETLTFLCYTAEASVALSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFN1</accession>
    <name>A0A7U8TFN1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GCV_T domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02957</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404137.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFN1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045179">
        <property type="entry name" value="YgfZ/GcvT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017703">
        <property type="entry name" value="YgfZ/GcvT_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22602">
        <property type="entry name" value="PTHR22602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03317">
        <property type="entry name" value="ygfZ_signature"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCV_T" evidence="3">
        <location>
            <begin position="23"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="368" mass="39447" checksum="1150CF60667E8BD6" modified="2021-06-02" version="1">MAAVPAPDPGPDAGAIWHYGDPLGEQRAGQADAVLVDRSHRAVLTLDGGDRQTWLHSISTQHVSDLPEGASTQNLSLDGQGRVEDHWIQTELGGTTYLDTEPWRGEPLLAYLRKMVFWSMVTPRAADMAVLSLLGPRLAEERVLDALGLDVLPAEWLAVPLAGGGIVRRMPDGLAGQIELDVVVKRGDRADWQRRLTQAGVRPAGIWAYEAHRVAHRVPARRPRLGVDTDERTIPHEVGWIGGPGAGAVHLNKGCYRGQETVARVHNLGRPPRMLVLLHLDESVQRPSTGDAVLAGGRTVGRLGTVVEHVELGPVALALLKRGLPGDTALVTGPEAEVAAVIDVDSLPPADDVGAGRRAVERLRGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFQ1</accession>
    <name>A0A7U8TFQ1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02982</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="210" mass="18699" checksum="A51661D8D3822E27" modified="2021-06-02" version="1" fragment="single">MSFVIAAPDLVAMATEDLAGIGASLTAANAAAAVPTSGLLAAAGDEVSAAIAALFSSHGQQYQAMSAQAAAFHARFVQALAGAMGAYAAAEAANASPLQTLEQGLLGAINAPAAALSGRPFIGNGTNGAPGTGEAGGPGGWLLGNGGNGGSGAPGQTGGAGGAAGLLGHGGTGGAGGTGASGGKGGTGGWLWGSGGAGGAGGSGGGSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFR2</accession>
    <name>A0A7U8TFR2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallophos domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclic nucleotide phosphodiesterase class-III family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404120.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFR2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004112">
        <property type="term" value="F:cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07402">
        <property type="entry name" value="MPP_GpdQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026575">
        <property type="entry name" value="GpdQ/CpdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="16"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="318" mass="34233" checksum="7C1B683C5E375B3F" modified="2021-06-02" version="1">MHRLRAAEHPRPDYVLLHISDTHLIGGDRRLYGAVDADDRLGELLEQLNQSGLRPDAIVFTGDLADKGEPAAYRKLRGLVEPFAAQLGAELVWVMGNHDDRAELRKFLLDEAPSMAPLDRVCMIDGLRIIVLDTSVPGHHHGEIRASQLGWLAEELATPAPDGTILALHHPPIPSVLDMAVTVELRDQAALGRVLRGTDVRAILAGHLHYSTNATFVGIPVSVASATCYTQDLTVAAGGTRGRDGAQGCNLVHVYPDTVVHSVIPLGGGETVGTFVSPGQARRKIAESGIFIEPSRRDSLFKHPPMVLTSSAPRSPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFW5</accession>
    <name>A0A7U8TFW5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404750.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424882"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="85" mass="8533" checksum="ADF2CA6D275E0C1A" modified="2021-06-02" version="1">MMCYRPAGSPLPGPEPATSGKRAPLDESPRHEKLDGGAGIVAHDVMLQGAGQPMAFGVPLTGSISAAGDHATVASIAQVARRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFY4</accession>
    <name>A0A7U8TFY4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="94" mass="10869" checksum="32B9F4BA930DED99" modified="2021-06-02" version="1">MPRSWWPTAPRIWAYSGNGTPSAELSGNRRQALQSKYQAAQRRFNFPDGETHTWAYWRAPLQAMLPDLQRVLGDGQRPRRGPRPRERRPASPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFZ2</accession>
    <name>A0A7U8TFZ2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_03120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404903.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFZ2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="127" mass="13859" checksum="6804DC5EE9269AC0" modified="2021-06-02" version="1">MIVVDASAALAALLNDGQARQLIAAERLHVPHLVDSEIASGLRRLAQRDRLGAADGRRALQTWRRLAVTRYPVVGLFERIWEIRANLSAYDASYVALAEALNCALVTADLRLSDTGQAQCPITVVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFZ6</accession>
    <name>A0A7U8TFZ6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03088</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898651.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFZ6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="89"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="304" mass="32988" checksum="0D4A080694343D2A" modified="2021-06-02" version="1">MSPSTSIEALDQPVKPVVFRPLTLRRRIKNSVATTFFFTSFVVALIPLVWLLWVVIARGWFAVTRSGWWTHSLRGVLPEQFAGGVYHALYGTLVQAGVAAVLAVPLGLMTAVYLVEYGTGRMSRVTTFTVDVLAGVPSIVAALFVFSLWIATLGFQQSAFAVALALVLLMLPVVVRAGEEMLRLVPDELREASYALGVPKWKTIVRIVAPIAMPGIVSGILLSIARVVGETAPVLVLVGYSHSINLDVFHGNMASLPLLIYTELTNPEHAGFLRVWGAALTLIIVVATINLAAAMIRFVATRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG00</accession>
    <name>A0A7U8TG00_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate mutase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG00"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010958">
        <property type="entry name" value="Chorismate_mutase_highGC-bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01808">
        <property type="entry name" value="CM_M_hiGC-arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="1">
        <location>
            <begin position="23"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="105" mass="11771" checksum="6A387E4A53CC9F6D" modified="2021-06-02" version="1">MRPEPPHHENAELAAMNLEMLESQPVPEIDTLREEIDRLDAEILALVKRRAEVSKAIGKARMASGGTRLVHSREMKVIERYSELGPDGKDLAILLLRLGRGRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG02</accession>
    <name>A0A7U8TG02_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG02"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="253" mass="27039" checksum="BAC926219853DB12" modified="2021-06-02" version="1">MLTGVTRQKILITGASSGLGAGMARSFAAQGRDLALCARRTDRLTELKAELSQRYPDIKIAVAELDVNDHERVPKVFAELSDEIGGIDRVIVNAGIGKGARLGSGKLWANKATIETNLVAALVQIETALDMFNQRGSGHLVLISSVLGVKGVPGVKAAYAASKAGVRSLGESLRAEYAQGPIRVTVLEPGYIESEMTAKSASTMLMVDNATGVKALVAAIEREPGRAAVPWWPWAPLVRLMWVLPPRLTRRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG33</accession>
    <name>A0A7U8TG33_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mscL</name>
        <name evidence="12" type="ORF">TBLG_03148</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405128.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG33"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="7 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="122"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="151" mass="16023" checksum="D682D3F2C1651E9C" modified="2021-06-02" version="1">MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLINRIGVNAQSDVGILRIGIGGGQTIDLNVLLSAAINFFLIAFAVYFLVVLPYNTLRKKGEVEQPGDTQVVLLTEIRDLLAQTNGDSPGRHGGRGTPSPTDGPRASTESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG34</accession>
    <name>A0A7U8TG34_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="79"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="151" mass="16699" checksum="132E92C7389AE15B" modified="2021-06-02" version="1">MTPDPRPDIPERRPSPQDLRLVRRSIRLSRPIRPGAKPSLRLYERLWRPASFHLASRITTRTERHRAAVSLHLGRAHRVLDIGCGPGNFTEPLSGHPPDGGLAVGFDISAPTLTSTALDNRGPRTCHIRGHARMVPFGDETFDAVCCFGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG67</accession>
    <name>A0A7U8TG67_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="365" mass="37524" checksum="A8D8CA545A6B355A" modified="2021-06-02" version="1">MPKCGESRAVGVAQHGCCAVASLEARRHSKRGAARMSRAGDDAERSDEEERRMSVMNGREVARESRDAQVFEFGTAPGSAVVKIPVQGGPIGGIAISRDGSLLVVTNNGTDTVSVVGTDTCRVTQTVTSVNEPFAIAMGNAEANRAYVSTVSSAYDAIAVIDVATNTVLGTHPLALSVSDLTLSPDDKYLYVSRNGTRGADVAVLDTTTGALIDVVDVSQAPGTTTQCVRMSPDGSVLYVGANGPSGGLLVVITTRAQSDGGRIGSRSRSRQKSSKPRGNQAAAGLRVVATIDIGSSVRDVALSPDGAIAYVASCGSDFGAVVDVIDTRTHQITSSRAISEIGGLVTRVSVSGDAIAPTWSARIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG75</accession>
    <name>A0A7U8TG75_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cysteine dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405649.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG75"/>
    <dbReference type="GeneID" id="45425037"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010300">
        <property type="entry name" value="CDO_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12918">
        <property type="entry name" value="PTHR12918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05995">
        <property type="entry name" value="CDO_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="188" mass="20634" checksum="050A4815A3D3B003" modified="2021-06-02" version="1">MVMPLVTPTTAVPSPGPTRLRVADLLRATDQAADDVLGGRCDHLLPDGGVPQTQRWYTRIHGDEELDIWLISWVPGQPTELHDHGGSLGALTVLSGSLNEYRWDGRRLRRRRLDAGDQAGFPLGWVHDVVWAPRPIGGPDAAGMAVAPTLSVHAYSPPLTAMSYYEITERNTLRRQRTELTDQPEGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGB7</accession>
    <name>A0A7U8TGB7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="5">HMBPP reductase</shortName>
            <ecNumber evidence="5">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ispH</name>
        <name evidence="6" type="ORF">TBLG_03283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="5"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405853.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGB7"/>
    <dbReference type="GeneID" id="45425084"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="247"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="335" mass="36297" checksum="E6640BC3246BDDBB" modified="2021-06-02" version="1">MVPTVDMGIPGASVSSRSVADRPNRKRVLLAEPRGYCAGVDRAVETVERALQKHGPPVYVRHEIVHNRHVVDTLAKAGAVFVEETEQVPEGAIVVFSAHGVAPTVHVSASERNLQVIDATCPLVTKVHNEARRFARDDYDILLIGHEGHEEVVGTAGEAPDHVQLVDGVDAVDQVTVRDEDKVVWLSQTTLSVDETMEIVGRLRRRFPKLQDPPSDDICYATQNRQVAVKAMAPECELVIVVGSRNSSNSVRLVEVALGAGARAAHLVDWADDIDSAWLDGVTTVGVTSGASVPEVLVRGVLERLAECGYDIVQPVTTANETLVFALPRELRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGC2</accession>
    <name>A0A7U8TGC2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="51" mass="5623" checksum="23A848F66BF5D6EA" modified="2021-06-02" version="1">MAAFRLAVMWIDDSSADVIKADFEALYHGDMLVEGDTSEQLEDLHPLPTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGE9</accession>
    <name>A0A7U8TGE9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein lpqW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030868597" evidence="2">
        <location>
            <begin position="38"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="3">
        <location>
            <begin position="108"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="635" mass="66160" checksum="40F0C36BBB1F8B9E" modified="2021-06-02" version="1">MGVPSPVRRVCVTVGALVALACMVLAGCTVSPPPAPQSTDTPRSTPPPPRRPTQIIMGIDWIGPGFNPHLLSDLSPVNAAISALVLPSAFRPIPDPNTPTGSRWEMDPTLLVSADVTNNHPFTVTYKIRPEAQWTDNAPIAADDFWYLWQQMVTQPGVVDPAGYHLITSVQSLEGGKQAVVTFAQPYPAWRELFTDILPAHIVKDIPGGFASGLARALPVTGGQFRVENIDPQRDEILIARNDRYWGPPSKPGIILFRRAGAPAALADSVRNGDTQVAQVHGGSAAFAQLSAIPDVRTARIVTPRVMQFTLRANVPKLADTQVRKAILGLLDVDLLAAVGAGTDNTVTLDQAQIRSPSDPGYVPTAPPAMSSAAALGLLEASGFQVDTNTSVSPAPSVPDSTTTSVSTGPPEVIRSRISKDGEQLTLVIGVAANDPTSVAVANTAADQLRDVGIAATVLALDPVTLYHDALNDNRVDAIVGWRQAGGNLATLLASRYGCPALQATTVPAANAPTTAPSAPIGPTPSAAPDTATPPPTAPRRPSDPGALVKAPSNLTGICDRSIQSNIDAALNGTKNINDVITAVEPRLWNMSTVLPILQDTTIVAAGPSVQNVSLSGAVPVGIVGDAGQWVKTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGJ7</accession>
    <name>A0A7U8TGJ7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Type-5 uracil-DNA glycosylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGJ7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033958">
        <property type="term" value="F:DNA-deoxyinosine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10031">
        <property type="entry name" value="UDG-F5_TTUDGB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044147">
        <property type="entry name" value="UdgB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="11">
        <location>
            <begin position="120"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="299" mass="31784" checksum="F70620F2D42DE881" modified="2021-06-02" version="1">MNIAAESSAKPVWGPPNFCAAAARMQDVRVLMHPKTGRAFRSPVEPGSGWPGDPATPQTPVAADAAQVSALAGGAGSICELNALISVCRACPRLVSWREEVAVVKRRAFADQPYWGRPVPGWGSKRPRLLILGLAPAAHGANRTGRMFTGDRSGDQLYAALHRAGLVNSPVSVDAADGLRANRIRITAPVRCAPPGNSPTPAERLTCSPWLNAEWRLVSDHIRAIVALGGFAWQVALRLAGASGTPKPRFGHGVVTELGAGVRLLGCYHPSQQNMFTGRLTPTMLDDIFREAKKLAGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGJ9</accession>
    <name>A0A7U8TGJ9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="90" mass="7461" checksum="C6E7F196D3752B9F" modified="2021-06-02" version="1">GADGTTGPDGNGTDAGSGSNAVNPGVGGGAGGIGGDGTNLGQTDVSGGLGGAGGNGGAGGGGGTGFNPGAPGDPGTQGATGANGQHGLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGL6</accession>
    <name>A0A7U8TGL6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGL6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="105"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="456" mass="49619" checksum="9B70C0471EDF113A" modified="2021-06-02" version="1">MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGFGLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQDFRTFDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIEANFRTYAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAVLDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFDSVNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGAAAERAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGP3</accession>
    <name>A0A7U8TGP3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease NucS</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nucS</name>
        <name evidence="3" type="ORF">TBLG_03505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NucS endonuclease family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGP3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00722">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002793">
        <property type="entry name" value="Endonuclease_NucS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38814">
        <property type="entry name" value="PTHR38814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01939">
        <property type="entry name" value="NucS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="226" mass="25163" checksum="072094F6FB33F4DF" modified="2021-06-02" version="1">MSRVRLVIAQCTVDYIGRLTAHLPSARRLLLFKADGSVSVHADDRAYKPLNWMSPPCWLTEESGGQAPVWVVENKAGEQLRITIEGIEHDSSHELGVDPGLVKDGVEAHLQALLAEHIQLLGEGYTLVRREYMTAIGPVDLLCRDERGGSVAVEIKRRGEIDGVEQLTRYLELLNRDSVLAPVKGVFAAQQIKPQARILATDRGIRCLTLDYDTMRGMDSGEYRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGR4</accession>
    <name>A0A7U8TGR4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406879.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGR4"/>
    <dbReference type="GeneID" id="45425300"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="152" mass="16626" checksum="60E64662DC2B343D" modified="2021-06-02" version="1">MMTTDQVHARHMLATSLVTGLDHVGIAVADLDVAIEWYHDHLGMILVHEEINDDQGIREALLAVPGSAAQIQLMAPLDESSVIAKFLDKRGPGIQQLACRVSDLDAMCRRLRSQGVRLVYETARRGTANSRINFIHPKDAGGVLIELVEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGR6</accession>
    <name>A0A7U8TGR6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="263" mass="28481" checksum="21E727AD0AA62B2C" modified="2021-06-02" version="1">MLIAGYLTDWRIMTTAQLRPIAPQKLHFSENLSVWVSDAQCRLVVSQPALDPTLWNTYLQGALRAYSKHGVECTLDLDAISDGSDTQLFFAAIDIGGDVVGGARVIGPLRSADDSHAVVEWAGNPGLSAVRKMINDRAPFGVVEVKSGWVNSDAQRSDAIAAALARALPLSMSLLGVQFVMGTAAAHALDRWRSSGGVIAARIPAAAYPDERYRTKMIWWDRRTLANHAEPKQLSRMLVESRKLLRDVEALSATTAATAGAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGT7</accession>
    <name>A0A7U8TGT7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898853.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425361"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="165" mass="18189" checksum="0F1E5367BA55805A" modified="2021-06-02" version="1">MNSGTLAGSLIFAAVLVMLIAVLARLMMRGWRRRSERQAELLGDLPDVPEHVSSATVTTRGLYVGATLSPAWNERVTVGDLGYRSKAVLTRYPSGIMVERARAQPIWIPTESIAAIRMERGVAGKVVAGIGILAIRWRLPSGTEIDVGFRADNRDEYQEWLEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGY0</accession>
    <name>A0A7U8TGY0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="78" mass="8341" checksum="4598DE26E2E0E184" modified="2021-06-02" version="1">MGRMAPDRHALGLGLLVGALERGMAAGVIQRVPLPPLSHLLLAALTESALQIADATDKDRTRVEVERAFMALLEGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGZ9</accession>
    <name>A0A7U8TGZ9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="294" mass="31841" checksum="49F5229545DC8A5E" modified="2021-06-02" version="1">MSKRPLRWLTEQITLAGMRPPISPQLLINRPAMQPVDLTGKRILLTGASSGIGAAATKQFGLHRAVVVAVARRKDLLDAVADRITGDGGTAMSLPCDLSDMEAIDALVEDVEKRIGGIDSLINNAGRSIRRPLAESLERWHDVERTMVLNYYAPLRLIRGLAPGMLERGDGHIINVATWGVLSEASPLFSVYNASKAALSAVSRIIETEWGSQGVHSTTLYYPLVATPMIAPTKAYDGLPALTAAEAAEWMVTAARTRPVRIAPRVAVAVNALDSIGPRWVNALMQRRNEQLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH70</accession>
    <name>A0A7U8TH70_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methoxy mycolic acid synthase 3 mmaA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403302.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH70"/>
    <dbReference type="GeneID" id="45424603"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="293" mass="33263" checksum="0897FA680944C63F" modified="2021-06-02" version="1">MSDNSTGTTKSRSNVDDVQAHYDLSDAFFALFQDPTRTYSCAYFERDDMTLHEAQVAKLDLTLGKLGLEPGMTLLDVGCGWGSVMKRAVERYDVNVVGLTLSKNQHAYCQQVLDKVDTNRSHRVLLSDWANFSEPVDRIVTIEAIEHFGFERYDDFFKFAYNAMPADGVMLLHSITGLHVKQVIERGIPLTMEMAKFIRFIVTDIFPGGRLPTIETIEEHVTKAGFTITDIQSLQPHFARTLDLWAEALQAHKDEAIEIQSAEVYERYMKYLTGCAKAFRMGYIDCNQFTLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI11</accession>
    <name>A0A7U8TI11_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">prs</name>
        <name evidence="8" type="ORF">TBLG_03181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405263.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI11"/>
    <dbReference type="GeneID" id="45424988"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="234"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="45"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="326" mass="35477" checksum="4CE64D17E783AC37" modified="2021-06-02" version="1">MSHDWTDNRKNLMLFAGRAHPELAEQVAKELDVHVTSQDAREFANGEIFVRFHESVRGCDAFVLQSCPAPVNRWLMEQLIMIDALKRGSAKRITAVMPFYPYARQDKKHRGREPISARLIADLLKTAGADRIVTVDLHTDQIQGFFDGPVDHMRGQNLLTGYIRDNYPDGNMVVVSPDSGRVRIAEKWADALGGVPLAFIHKTRDPRVPNQVVSNRVVGDVAGRTCVLIDDMIDTGGTIAGAVALLHNDGAGDVIIAATHGVLSDPAAQRLASCGAREVIVTNTLPIGEDKRFPQLTVLSIAPLLASTIRAVFENGSVTGLFDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI31</accession>
    <name>A0A7U8TI31_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rho</name>
        <name evidence="12" type="ORF">TBLG_03479</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="11">
        <location>
            <begin position="223"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="76"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="344"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="356"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="602" mass="65034" checksum="98EF7A32ECC466C1" modified="2021-06-02" version="1">MTDTDLITAGESTDGKPSDAAATDPPDLNADEPAGSLATMVLPELRALANRAGVKGTSGMRKNELIAAIEEIRRQANGAPAVDRSAQEHDKGDRPPSSEAPATQGEQTPTEQIDSQSQQVRPERRSATREAGPSGSGERAGTAADDTDNRQGGQQDAKTEERGTDAGGDQGGDQQASGGQQARGDEDGEARQGRRGRRFRDRRRRGERSGDGAEAELREDDVVQPVAGILDVLDNYAFVRTSGYLPGPHDVYVSMNMVRKNGMRGGDAVTGAVRVPKEGEQPNQRQKFNPLVRLDSINGGSVEDAKKRPEFGKLTPLYPNQRLRLETSTERLTTRVIDLIMPIGKGQRALIVSPPKAGKTTILQDIANAITRNNPECHLMVVLVDERPEEVTDMQRSVKGEVIASTFDRPPSDHTSVAELAIERAKRLVEQGKDVVVLLDSITRLGRAYNNASPASGRILSGGVDSTALYPPKRFLGAARNIEEGGSLTIIATAMVETGSTGDTVIFEEFKGTGNAELKLDRKIAERRVFPAVDVNPSGTRKDELLLSPDEFAIVHKLRRVLSGLDSHQAIDLLMSQLRKTKNNYEFLVQVSKTTPGSMDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI33</accession>
    <name>A0A7U8TI33_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898703.1">
        <property type="nucleotide sequence ID" value="NZ_KK338665.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI33"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="293" mass="31991" checksum="3CEC83C346F5CB17" modified="2021-06-02" version="1">MTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKDFDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDTLTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQHPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI69</accession>
    <name>A0A7U8TI69_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03286</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405863.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI69"/>
    <dbReference type="GeneID" id="45425087"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="65" mass="6973" checksum="51000929DB16C82B" modified="2021-06-02" version="1">MRTTVTVDDALLAKAAELTGVKEKSTLLREGLQTLVRVESARRLAALGGTDPQATAAPRRRTSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIC8</accession>
    <name>A0A7U8TIC8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406233.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIC8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004736">
        <property type="entry name" value="MHS_symport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00883">
        <property type="entry name" value="2A0106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="4"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="425" mass="44575" checksum="67D44D03F0EA7256" modified="2021-06-02" version="1">MKRVALACLVGSAIEFYDFLIYGTAAALVFPTVFFPHLDPTVAAVASMGTFAVAFLSRPFGAAVFGYFGDRLGRKKTLVATLLIMGLATVTVGLVPTTVAIGAAAPLILTTMRLLQGFAVGGEWAGSALLSAEYAPASKRGWYGMFTVVGGGIALVLTSLTFLGVNYTIGESSPTFMQWGWRIPFLVSAALIAVALYVRFNIDETPVFARERADEKTRLGPAETPIAQVLRRQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILFDSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVMPLIDSGSPSLFAVAVVGMYAIGGFGFGPTASFIPELFATSYRYTGSALAANLAGVAGGALPPVIAGALVATYGSWAIGVMLAILALISLVCTYRLPETAGSALVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR17</accession>
    <name>A0A7U8TR17_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03644</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415911.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR17"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="PTHR11601:SF34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="3"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD14746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="393" mass="40947" checksum="D8CF10B6F88C85A1" modified="2021-06-02" version="1">MAYLDHAATTPMHPAAIEAMAAVQRTIGNASSLHTSGRSARRRIEEARELIADKLGARPSEVIFTAGGTESDNLAVKGIYWARRDAEPHRRRIVTTEVEHHAVLDSVNWLVEHEGAHVTWLPTAADGSVSATALREALQSHDDVALVSVMWANNEVGTILPIAEMSVVAMEFGVPMHSDAIQAVGQLPLDFGASGLSAMSVAGHKFGGPPGVGALLLRRDVTCVPLMHGGGQERDIRSGTPDVASAVGMATAAQIAVDGLEENSARLRLLRDRLVEGVLAEIDDVCLNGADDPMRLAGNAHFTFRGCEGDALLMLLDANGIECSTGSACTAGVAQPSHVLIAMGVDAASARGSLRLSLGHTSVEADVDAALEVLPGAVARARRAALAAAGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR43</accession>
    <name>A0A7U8TR43_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Carbon starvation protein A cstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03683</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="590"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="10">
        <location>
            <begin position="67"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="11">
        <location>
            <begin position="506"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD14785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="761" mass="80453" checksum="F6BB8D85FFC3B2DF" modified="2021-06-02" version="1">MAAPTPSNRIEERSGHASCVRADADLPPVAILGRSPITLRHKIFFVAVAVIGALAWTVVAFFRNEPVNAVWIVVAAGCTYIIGFRFYARLIEMKVVRPRDDHATPAEILDDGTDYVPPPDPAGGNSDTTSPPIAGAEPLVRTQYWPPQMGYLPSSIWIVVGAVLAGCVQDYLVLWISVRRRGRSLGQMVRDELGATAGVAALVGIPVIITIVIAVLALVVVRALAKSPWGVFSIAMTIPIAIFMGCYLRFLRPGRVSEVSLIGIGLLLLAVVSGDWVAHTSWGAAWFSLSPVTLCWLLISYGFAASVLPVWLLLAPRDYLSTFMKVGTIALLAIGVCAAHPIIEAPAVSKFAGSGNGPVFAGSLFPFLFITIACGALSGFHALICSGTTPKMLEKEGQMRVIGYGGMMTESFVAVIALLTAAILDQHLYFTLNAPSLHTHDSAATAAKYVNGLGLTGSPVTPDHISQAAASVGEQTIVSRTGGAPTLAFGMAEMLHRVVGGVGLKAFWYHFAIMFEALFILTTVDAGTRAARFMISDALGNFGGVLRKLQNPSWRPGAWACSLVVVAAWGSILLLGVTDPLGGINTLFPLFGIANQLLAGIALTVITVVVIKKGRLKWAWIPGIPLLWDLAVTLTASWQKIFSADPSVGYWTQHAHYAAAQHAGETAFGSATNADEINDVVRNTFVQGTLSIVFVVVVVLVVVAGVIVALKTIRGRGIPLAEDDPAPSTLFAPAGLIPTAAERKLQRRLGAPASASVAAPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR66</accession>
    <name>A0A7U8TR66_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine/threonine-protein kinase PknK</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein kinase K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03700</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031326">
        <property type="term" value="P:regulation of cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016236">
        <property type="entry name" value="Ser/Thr_kinase_PknK_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000574">
        <property type="entry name" value="Ser/Thr_PK_PknK_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR000574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1110" mass="119501" checksum="4541BF18BCD3E463" modified="2021-06-02" version="1">MTDVDPHATRRDLVPNIPAELLEAGFDNVEEIGRGGFGVVYRCVQPSLDRAVAVKVLSTDLDRDNLERFLREQRAMGRLSGHPHIVTVLQVGVLAGGRPFIVMPYHAKNSLETLIRRHGPLDWRETLSIGVKLAGALEAAHRVGTLHRDVKPGNILLTDYGEPQLTDFGIARIAGGFETATGVIAGSPAFTAPEVLEGASPTPASDVYSLGATLFCALTGHAAYERRSGERVIAQFLRITSQPIPDLRKQGLPADVAAAIERAMARHPADRPATAADVGEELRDVQRRNGVSVDEMPLPVELGVERRRSPEAHAAHRHTGGGTPTVPTPPTPATKYRPSVPTGSLVTRSRLTDILRAGGRRRLILIHAPSGFGKSTLAAQWREELSRDGAAVAWLTIDNDDNNEVWFLSHLLESIRRVRPTLAESLGHVLEEHGDDAGRYVLTSLIDEIHENDDRIAVVIDDWHRVSDSRTQAALGFLLDNGCHHLQLIVTSWSRAGLPVGRLRIGDELAEIDSAALRFDTDEAAALLNDAGGLRLPRADVQALTTSTDGWAAALRLAALSLRGGGDATQLLRGLSGASDVIHEFLSENVLDTLEPELREFLLVASVTERTCGGLASALAGITNGRAMLEEAEHRGLFLQRTEDDPNWFRFHQMFADFLHRRLERGGSHRVAELHRRASAWFAENGYLHEAVDHALAAGDPARAVDLVEQDETNLPEQSKMTTLLAIVQKLPTSMVVSRARLQLAIAWANILLQRPAPATGALNRFETALGRAELPEATQADLRAEADVLRAVAEVFADRVERVDDLLAEAMSRPDTLPPRVPGTAGNTAALAAICRFEFAEVYPLLDWAAPYQEMMGPFGTVYAQCLRGMAARNRLDIVAALQNFRTAFEVGTAVGAHSHAARLAGSLLAELLYETGDLAGAGRLMDESYLLGSEGGAVDYLAARYVIGARVKAAQGDHEGAADRLSTGGDTAVQLGLPRLAARINNERIRLGIALPAAVAADLLAPRTIPRDNGIATMTAELDEDSAVRLLSAGDSADRDQACQRAGALAAAIDGTRRPLAALQAQILHIETLAATGRESDARNELAPVATKWAELGLSRLLVDAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR83</accession>
    <name>A0A7U8TR83_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03725</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416127.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR83"/>
    <dbReference type="GeneID" id="45427103"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045276">
        <property type="entry name" value="YbiO_bact"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30460">
        <property type="entry name" value="PTHR30460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="308" mass="33381" checksum="050A151746E0D8F0" modified="2021-06-02" version="1">MTTSGTVLATSIAQHWHNFWRGEIGDWILNRGLRIVMLLIAAVLAARFVTWLANRVTRRLDLGFTESDALVRSEATKHRQAVASVISWVSIVLIYVVVVYEVIDVLPVPVGALVGPAAVLGAALGFGAQRLVQDLLAGFFIIVEKQYGFGDLVELSMVGSPENAAGTVEDVTLRVTKLRSSEGEVFTVPNGNIVKSVNLSKDWARAVVDIPVPTSADLGRVNEVLHQECEHARHDSLLGELLLDEPTVMGVERIEVDTVTLRLVARTLPGKQFEAGRQLRVLVIRALTRAGIVTAADARAAVAESPEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRD3</accession>
    <name>A0A7U8TRD3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="110" mass="11728" checksum="A23272F9CEA98191" modified="2021-06-02" version="1">MGWEFGVLLILIAVLAVFLAPRLIPRGPRGDLASGTLLVTGVSPRPDAGGQQYVTIAGIITGPTVNEYAVYQRMAVDVDQWPTVGQILPVVYSPKNPDNWTFTPNGPPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRJ5</accession>
    <name>A0A7U8TRJ5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acyl-L-amino acid amidohydrolase amiA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03944</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417220.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRJ5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="389" mass="41227" checksum="B7D595748A1522A0" modified="2021-06-02" version="1">MSLADAAESWLAAHHDDLVGWRRHIHRYPELGRQEYATTQFVAERLADAGLNPKVLPGGTGLTCDFGPQHQPRIALRADMDALPMAERTGAPYASTMPNVAHACGHDAHTAILLGAALALASVPELPVGVRLIFQAAEELMPGGAIDAIAAGALAGVSRIFALHCDPRLEVGKVAVRQGPITSAADSIEITLYSPGGHTSRPHLTADLVYGLGTLVTGLPGVLSRRIDPRNSTVLVWGAVNAGMAANAIPQTGVLSGTVRTASRQTWVDLEELVRQAISALLLPLAIEHTLQYRRGVPPVVNEEISTRILAHAIEAIGPGVLADTRQSGGGEDFSWYLEEVPGAMARLGVWSGDGLQLDLHQPTFDIDERALAIGLRVMVNIIEQAAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN3</accession>
    <name>A0A7U8TRN3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417112.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRN3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017523">
        <property type="entry name" value="CHP03089"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03089">
        <property type="entry name" value="TIGR03089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="229" mass="23723" checksum="850DF988E832306C" modified="2021-06-02" version="1">MLRADPVGPRITYYDDATGERIELSAVTLANWAAKTGNLLRDELAAGPASRVAILLPAHWQTAAVLFGVWWIGAQAILDDSPADVALCTADRLAEADAVVNSAAVAGEVAVLSLDPFGRPATGLPVGVTDYATAVRVHGDQIVPEHNPGPVLAGRSVEQILRDCAASAAARGLTAADRVLSTASWAGPDELVDGLLAILAAGASLVQVANPDPAMLQRRIATEKVTRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN8</accession>
    <name>A0A7U8TRN8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="9">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">guaA</name>
        <name evidence="12" type="ORF">TBLG_04004</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="9"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417952.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRN8"/>
    <dbReference type="GeneID" id="45427392"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="11">
        <location>
            <begin position="206"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="233"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD15106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="525" mass="56060" checksum="DFBE06100BA16FAF" modified="2021-06-02" version="1">MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVALVLSGGPASVYADGAPKLDPALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAGAPVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAVAAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGAVRDVLDGKTAEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQPFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDAMTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSKPPATIEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRY1</accession>
    <name>A0A7U8TRY1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRY1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="314" mass="33194" checksum="26144BA917E09274" modified="2021-06-02" version="1">MNSRAPRNLAVSSPSAQVTGRMVQNGENLFQFRREGPQVQLSFQDRTYLVTGGGSGIGKGVAAGLVAAGAAVMIVGRNPDKLAAAVKDIEALKTGAIGYEPADITDEEQTLRVVDAATAWHGRLHGVVHCAGGSQTIGPITQIDSQAWRRTVDLNVNGTMYVLKHAARELVRGGGGSFVGISSIAASNTHRWFGAYGVTKSAVDHMMKLAADELGPSWVRVNSIRPGLIRTDLVVPVTESPELSADYRVCTPLPRVGEVEDVANLAMFLLSDAASWITGQVINVDGGHMLRRGPDFSPMLEPVFGADGLRGVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TS28</accession>
    <name>A0A7U8TS28_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022171">
        <property type="entry name" value="PPE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12484">
        <property type="entry name" value="PPE-SVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-SVP" evidence="3">
        <location>
            <begin position="306"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="390" mass="39039" checksum="4645FE706DA124D5" modified="2021-06-02" version="1">MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAASAFQSVVWGLTVGSWIGSSAGLMAAAASPYVAWMSVTAGQAQLTAAQVRVAAAAYETAYRLTVPPPVIAENRTELMTLTATNLLGQNTPAIEANQAAYSQMWGQDAEAMYGYAATAATATEALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPAQGVVPSSKLGGLWTAVSPHLSPLSNVSSIANNHMSMMGTGVSMTNTLHSMLKGLAPAAAAQAVQTAAQNGVQAMSSLGSSLGSSGLGAGVAANLGRAASVGSLSVPPAWAAANQAVTPAARALPLTSLTSAAQTAPGHMLGGLPLGHSVNAGSGINNALRVPARAYAIPRTPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT83</accession>
    <name>A0A7U8TT83_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PseudoU_synth_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417215.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT83"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="93"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="305" mass="33280" checksum="5950A190DC9F53C5" modified="2021-06-02" version="1">MALRPEDRLLSVHDVLGPVRVRLLGGSVLAELTARFGVAARAKVLAGEVVDDDGAVVDSGTVLPPGSVVHLYRDLPDEVPVPFDVPVLHQDADIVVVDKPHFLATMPRGRHVAQTALVRLRRELGLPELSPAHRLDRLTAGVLLFTTRREVRGSYQTMFARGLVRKTYLARAPVAPGLALPRLVRSRIVKRRGHLQAVCEPGVPNAETLVERIARDGLYRLTPTTGRTHQLRVHMAALGIPIMGDPLYPNVISVAAHDFSTPLQLLAQRIEFDDPLTGSHREFASTRTLTGATLPTWSAAADCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTB3</accession>
    <name>A0A7U8TTB3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900051.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTB3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="275" mass="28659" checksum="47634BCA57C3CB3E" modified="2021-06-02" version="1">MNETPHAPVVEQVLVAAAFGNQPGSWPLPTAITPHHLWLRAVAAGGQGRYAHAYGDLSVLRRLVPAGPLASLAHSTQGSLLRQLGWHTLARGWDGRALALAGADREAGADALIGLAADALGVGRFAAAGALLDRADPLVVSPLVADRLAVRRRWVAAELAMATGDGATAVRHAEEAVELTQAMAVASARHRVKSDVVLAAALCSAGAVARARAVGEEALDATARFGLLPLRWALACLLIDIGTVTFSAQQLRELTKIRNICAGQVRRAGGCWRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTB4</accession>
    <name>A0A7U8TTB4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2384 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899956.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTB4"/>
    <dbReference type="GeneID" id="45427173"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024467">
        <property type="entry name" value="Xre/MbcA/ParS-like_toxin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09722">
        <property type="entry name" value="DUF2384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2384" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="115" mass="12818" checksum="EE5D945B1F839517" modified="2021-06-02" version="1">MAVTLDRAVEASEIVDALKPFGVTQVDVAAVIQVSDRAVRGWRTGDIRPERYDRLAQLRDLVLLLSDSLTPRGVGQWLHAKNRLLDGQRPVDLLAKDRYEDVRSAAESFIDGAYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTJ6</accession>
    <name>A0A7U8TTJ6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical alanine and valine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023840">
        <property type="entry name" value="T7SS_Rv3446c"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03931">
        <property type="entry name" value="T7SS_Rv3446c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="404" mass="41584" checksum="AF9EE8A86B9C3A4A" modified="2021-06-02" version="1">MSPHRAVIEAGPGAIRRLCCGADVVADTAVSAAALAAIDDQVALLDERPVAVDSLWFDALRSVAVDHRDGPVVVHPSWWSAARVEVVTAAARTLTRDVVVHPRSWLLRQASSGVSAATVVVEIAERLVLVAGAEVAAVARRTDAESVAGQVGSVIARMTRGITVVVLIDVPSTVAGAAALAAAIAGAVRGTGSSVVEIDGVRLARLARAALPPSDEPADPAARPATRSRVPTLARVAAAGVALALLAPAAVVRHGATTLQRPPTTLLVEGRVALTIPADWSTQRVVSGPGSARVQVTSPADPEVALHVTQSPVPGETLPGTAQRLKRAIDASPAGVFVDFNPSDIRAGRPAVTYREVRAGHQVRWTILLDGAVRISVGCQSGPGHEDLLREVCAQAVRSVHAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTK6</accession>
    <name>A0A7U8TTK6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900009.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTK6"/>
    <dbReference type="GeneID" id="45427301"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="170"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="394" mass="40740" checksum="184E98E50534559E" modified="2021-06-02" version="1">MPAASASDRVEELVRRRGGELVELSHAIHAEPELAFAEHRSCAKAQALVAERGFEITTAAGGLDTAFRADYGSGPLVVGVCAEYDALPGIGHACGHNIIAASAVGTALALAEVADDLGLTVALLGTPAEESGGGKALMLQAGTFDDVAVAVMVHPGPTDIAGARSLALSEVTVRYRGKESHAAVAPHLGVNAADAVTVAQVAIGVLRQQLAPGQMVHGIVTDGGQAVNVIPGQARLQYAMRAVESDSLRELQTRMFACFAAGALAAGCEYEIDEAAPAYAELKPDPWLADVCREEMQRLGREPLLPALEAELPLGSTDMGNVTQVLPGIHPVIGLDAGAATVHQRAFTVASAGASADRAVVDGAIMLARTVVRLAQTPDERDRVLAAQQRRAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTN0</accession>
    <name>A0A7U8TTN0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899954.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTN0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="114" mass="12692" checksum="119D0463FA24AB59" modified="2021-06-02" version="1">MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLLGGDKAGNWKRWYDNNIPIADQRSENWLASEHGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTP8</accession>
    <name>A0A7U8TTP8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTP8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="299" mass="31646" checksum="E6DB70B01D16190D" modified="2021-06-02" version="1">MSARSVAPSQVMRRAASALYSLNPAMPVLLRPDGAVQVGWDPRRAVLVRPPRGLTATGLAALLRSMRSPIPITELQRQAAERGLVDGDAMANLVAQLVGAGVATPLANPGNLDSRRRAASIRVHGRGPLSDLLVQALRCSGARIRHSSQPHAAVTPAGVDLVVLSDYLVADPHMVRDLHTERVPHLPVRVRDGTGMVGPLVVPGVTSCLGCADLHRSDRDAAWPAIAAQLRDTVGVADRATLLATAALALSQVNRVIAAVRGQEATPEPPSALNTTLEFDLNAGSIVARQWTRHPRCFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTU2</accession>
    <name>A0A7U8TTU2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTU2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="4"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="570" mass="62961" checksum="77965967116EAD35" modified="2021-06-02" version="1">MVVVGTDAHKYSHTFVATDEVGRQLGEKTVKATTAGHATAIMWAREQFGLELIWGIEDCRNMSARLERDLLAAGQQVVRVPTKLMAQTRKSARSRGKSDPIDALAVARAVLRETDLPLATHDETSRELKLLTDRRDVLVAQRTSAINRLRWLVHELDPERAPAARSLDAAKHQQALRTWLDTQPGLVAELARAELTDIIRLTGEINTLAQRISARVHQVAPALLEIPGCAELTAAKIVGEAAGVTRFKSEAAFACHAAVAPIPVWSGNTAGQMRLSRSGNRQLNAALHRIALTQIRMTDSRGQAYYQRLQDAGKTKRAALRCLKRRLARTVFQALRTVHQPSSEHTQPAAACHRSYCSSHLGEPPRLTDMTQKTRIQPLPPKRAGLLIRALYRIAKRRFGEVPEPFTVTAHHRRLLIANVVHEALLQRASRKLPPSVRELAVFWTARSIGCSWCVDFGAMLQRLDGLDVDRLTDIDNYATSSKFSDDERAAIAYAEAMTADPHSVTDEQVADLRARFGEAGVIELTYQIGVENMRARMNSALGITEQGFNSGDACRVPWAAPDVPSAESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTY8</accession>
    <name>A0A7U8TTY8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_04136</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418942.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="149" mass="16002" checksum="1808DAFC0B00D367" modified="2021-06-02" version="1">MHAEGPPSVICIRLLVGLVFLSEGIQKFMYPDQLGPGRFERIGIPAATFFADLDGVVEIVCGTLVLLGLLTRVAAVPLLIDMVGAIVLTKLRALQPGGFLGVEGFWGMAHAARTDLSMLLGLIFLLWSGPGRWSLDRRLSKRATACGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2B8</accession>
    <name>A0A7U8Y2B8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="40"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="138" mass="14528" checksum="F53A3C3CD8C26507" modified="2021-06-02" version="1" fragment="single">MPQSSIASSPSPAASRPQATCPPPNERMIMPKRSEYRQGTPNWVDLQTTDQSAAKKFYTSLFGWGYDDNPVPGGGGVYSMATLNGEAVAAIAPMPPGAPEGMPPIWNTYIAVDDVDAVVDKVVPGGGQVMMPAFDIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2C8</accession>
    <name>A0A7U8Y2C8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03078</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404757.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2C8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="439" mass="48672" checksum="54FF06E605F16C52" modified="2021-06-02" version="1">MDAAQVIEPAHAGQDVDEAAVAARELSGAERALVGDLVRQARAEGVALTGPDGLLKALTKTVLEAALQEEMTEHLGYDRHAAAGRGSGNSRNGSRNKKVITDACGQVEIAVPRDRNGTFEPVIVGKRKRRVTDVDRVVLSLYAKGLTTGEIAAHFADVYGVSVSKDTISRITDRVIEEMQAWWSRPLEKVYAAVFIDAIMVKIRDGQVRNRPVYAAIGVDLDGHKDILGMWAGEGDGESAKFWLAVLTDLRNRGVKDIFFLVCDGLKGLPDSVSAAFPLATVQTCIIHLIRNTFRYASRKYWDKISVDLKPIYTAASAAEARLRYEEFAEKWGKPYPAITRLWDSAWEEFIPFLDYDVEIRRVPCSTNAIESLNARYRRAVRARGHFPNEQSALKTLYLVTRSLDPKGTGQTKWAVRWKPALNALAITFADRMPAAEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2D9</accession>
    <name>A0A7U8Y2D9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methoxy mycolic acid synthase 2 mmaA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02781</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="208" mass="23282" checksum="F47603FA83DBB253" modified="2021-06-02" version="1">MVNDLTPHFEDVQAHYDLSDDFFRLFLDPTQTYSCAHFEREDMTLEEAQIAKIDLALGKLGLQPGMTLLDIGCGWGATMRRAIAQYDVNVVGLTLSKNQAAHVQKSFDEMDTPRDRRVLLAGWEQFNEPVDRIVSIGAFEHFGHDRHADFFARAHKILPPDGVLLLHTITGLTRQQMVDHGLPLTVVAGPLSQVHRDRNLPGGPTSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2H6</accession>
    <name>A0A7U8Y2H6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="153" mass="13756" checksum="62B95FD53CB19885" modified="2021-06-02" version="1">MIAAPEAIAAAATDLASIGSTIGAANAAAAANTTAVLAAGADQVSVAIAAAFGAHGQAYQALSAQAATFHIQFVQALTAGAGSYAAAEAASAASITSPLLDAINAPFLAALGRPLIGNGADGAPGTGAAGGAGGLLFGNGGAGGPGASGGALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2L5</accession>
    <name>A0A7U8Y2L5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tetronasin-transport membrane protein ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898775.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="548" mass="56650" checksum="3B830A76B619E244" modified="2021-06-02" version="1">MSSTVIDRARPAGHRAPHRGSGFTGTLGLLRLYLRRDRVSLPLWVLLLSVPLATVYIASVETVYPDRSARAAAAAAIMASPAQRALYGPVYNDSLGAVGIWKAGMFHTLIAVAVILTVIRHTRADEESGRAELIDSTVVGRYANLTGALLLSFGASIATGAIGALGLLATDVAPAGSVAFGVALAASGMVFTAVAAVAAQLSPSARFTRAVAFAVLGTAFALRAIGDAGSGTLSWCSPLGWSLQVRPYAGERWWVLLLSLATAAVLTVLAYRLRAGRDVGAGLIAERPGAGTAGPMLSEPFGLAWRLNRGSLLLWTVGLCLYGLVMGSVVHGIGDQLGDNTAVRDIVTRMGGTGALEQAFLALAFTMIGMVAAAFAVSLTLRLHQEETGLRAETLLAGAVSRTHWLASHLAMALAGSAVATLISGVAAGLAYGMTVGDVGGKLPTVVGTAAVQLPAVWLLSAVTVGLFGLAPRFTPVAWGVLVGFIALYLLGSLAGFPQMLLNLEPFAHIPRVGGGDFTAVPLLWLLAIDAALITLGAMAFRRRDVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2M7</accession>
    <name>A0A7U8Y2M7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein lpqP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010126">
        <property type="entry name" value="Esterase_phb"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10503">
        <property type="entry name" value="Esterase_PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031221554" evidence="2">
        <location>
            <begin position="22"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="280" mass="29609" checksum="ECF0565BA0875A33" modified="2021-06-02" version="1">MLRRVAILLAAVLAFAGCSGGTRLATGFGNGNSVHTLDVDGAGRSYRLYKPVGLPSSAPLVVMLHGGFGSAKQAERSYGWDELADSEKFLVAYPDGYHRAWNANGGGCCGRPAREGVDDIGFVRAVVADIANNVSIDPARVYVTGMSNGAIMSYTLACNTSIFAAIGVVSGTQLDPCQSPRPVSVIHIHGTADPLVRYHGGPGAGFARIDGPPVPDLNAFWREVNRCGALDTTTEGPVTTSGATCADNRRVVLLTVDDAGHRWPSFATQTLWRFFAAHFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2N3</accession>
    <name>A0A7U8Y2N3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406624.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2N3"/>
    <dbReference type="GeneID" id="45425259"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="161" mass="17209" checksum="1F088A2907C60317" modified="2021-06-02" version="1">MRMSAKAEYAVRAMVQLATAASGTVVKTDDLAAAQGIPPQFLVDILTNLRTDRLVRSHRGREGGYELARPGTEISIADVLRCIDGPLASVRDIGLGDLPYSGPTTALTDVWRALRASMRSVLEETTLADVAGGALPEHVAQLADDYRAQESTRHGASRHGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2P8</accession>
    <name>A0A7U8Y2P8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404617.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2P8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021421">
        <property type="entry name" value="DUF3071"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11268">
        <property type="entry name" value="DUF3071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="253" mass="27373" checksum="1060E3FA647A93DE" modified="2021-06-02" version="1">MRELKVVGLDADGKNIICQGAIPSEQFKLPVDDRLRAALRDDSVQPEQAQLDIEVTNVLSPKEIQARIRAGASVEQVAAASGSDIARIRRFAHPVLLERSRAAELATAAHPVLADGPAVLTMQETVAAALVARGLNPDSLTWDAWRNEDSRWTVQLAWKAGRSDNLAHFRFTPGAHGGTATAIDDTAHELINPTFNRPLRPLAPVAHLDFDEPEPAQPTLTVPSAQPVSNRRGKPAIPAWEDVLLGVRSGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2R9</accession>
    <name>A0A7U8Y2R9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipase lipH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03588</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407279.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2R9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002168">
        <property type="entry name" value="Lipase_GDXG_HIS_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01173">
        <property type="entry name" value="LIPASE_GDXG_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="4">
        <location>
            <begin position="87"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD13004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="320" mass="34053" checksum="D95637B78DEB12BD" modified="2021-06-02" version="1">MPSLDNTADEKPAIDPILLKVLDAVPFRLSIDDGIEAVRQRLRDLPRQPVHPELRVVDLAIDGPAGPIGTRIYWPPTCPDQAEAPVVLYFHGGGFVMGDLDTHDGTCRQHAVGADAIVVSVDYRLAPEHPYPAAIEDAWAATRWVAEHGRQVGADLGRIAVAGDSAGGTIAAVIAQRARDMGGPPIVFQLLWYPSTLWDQSLPSLAENADAPILDVKAIAAFSRWYAGEIDLHNPPAPMAPGRAENLADLPPAYIAVAGYDPLRDDGIRYGELLAAAGVPVEVHNAQTLVHGYVGYAGVVPAATEATNRGLVALRVVLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2S7</accession>
    <name>A0A7U8Y2S7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="80" mass="8151" checksum="C59E48A1B3365FFB" modified="2021-06-02" version="1">MVAASIVHHSAAPANRGRYHGIWSMTPVVASVVVPIMASYGPIHGAHLLAAVVVGSAGAALCLPLARALRRPTPSAMTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2W0</accession>
    <name>A0A7U8Y2W0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405600.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2W0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="301" mass="32497" checksum="3B608922D291031C" modified="2021-06-02" version="1">MARQRFRDQVVLITGASSGIGEATAKAFAREGAVVALAARREGALRRVAREIEAAGGRAMVAPLDVSSSESVRAMVADVVGEFGRIDVVFNNAGVSLVGPVDAETFLDDTREMLEIDYLGTVRVVREVLPIMKQQRSGRIMNMSSVVGRKAFARFAGYSSAMHAIAGFSDALRQELRGSGIAVSVIHPALTQTPLLANVDPADMPPPFRSLTPIPVHWVAAAVLDGVARRRARVVVPFQPRLLMVGDAFSPRYGDRVVRLLESKIFGRLIGSYRGSVYRHQPTESAKAQAAQPERGYSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2X0</accession>
    <name>A0A7U8Y2X0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898724.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425063"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="60" mass="6055" checksum="208FED4DE3E94DE3" modified="2021-06-02" version="1">MDSITVGYQAAQTGGYSPPTNLLINGQAVTIDQTPITSSPTTPPPTTPPEIPTGGTVIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Z9</accession>
    <name>A0A7U8Y2Z9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proline-rich antigen pra</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010432">
        <property type="entry name" value="RDD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06271">
        <property type="entry name" value="RDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RDD" evidence="7">
        <location>
            <begin position="89"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="240" mass="25064" checksum="D3826BE6CC0BC7F9" modified="2021-06-02" version="1">MTEQPPPGGSYPPPPPPPGPSGGHEPPPAAPPGGSGYAPPPPPSSGSGYPPPPPPPGGGAYPPPPPSAGGYAPPPPGPAIRTMPTESYTPWITRVLAAFIDWAPYVVLVGIGWVIMLVTQTSSCVTSISEYDVGQFCVSQPSMIGQLVQWLLSVGGLAYLVWNYGYRQGTTGSSIGKSVLKFKVVSETTGQPIGFGMSVVRQLAHFIDAIICFVGFLFPLWDAKRQTLADKIMTTVCVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y309</accession>
    <name>A0A7U8Y309_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Para-nitrobenzyl esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y309"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COesterase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="229" mass="25170" checksum="00BD01CD1433BB46" modified="2021-06-02" version="1">MVVDSCVAESRYGPVRGADDGRVKVWKGIRYAAPPLGDLRFRTPEPPERWTEVADATTFGPACPQPAIPNMPLDLGASQSEDCWSLNIWAPADTEPGDGKPVMVWLHGGAYILGSGSQPLYNGRRLAASGDVVVVTVNYRLGALGFLDLSSFNTSRRRFDSNIGLRDVLAVLRWVADNIAVFGGDPEKVTLFGESARESSRPCSPPRRPRVCSRRRSPRAHRRHRSTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y331</accession>
    <name>A0A7U8Y331_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpB</name>
        <name evidence="13" type="ORF">TBLG_03486</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cell membrane</location>
            <topology evidence="11 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 11 12" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="250" mass="27433" checksum="535B7C639A880571" modified="2021-06-02" version="1">MTETILAAQIEVGEHHTATWLGMTVNTDTVLSTAIAGLIVIALAFYLRAKVTSTDVPGGVQLFFEAITIQMRNQVESAIGMRIAPFVLPLAVTIFVFILISNWLAVLPVQYTDKHGHTTELLKSAAADINYVLALALFVFVCYHTAGIWRRGIVGHPIKLLKGHVTLLAPINLVEEVAKPISLSLRLFGNIFAGGILVALIALFPPYIMWAPNAIWKAFDLLVGAIQAFIFALLTILYFSQAMELEEEHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y339</accession>
    <name>A0A7U8Y339_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898763.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y339"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="275" mass="30213" checksum="22F50D4861D06C8C" modified="2021-06-02" version="1">MLLPVLEPADRPCDAPGWFLYLTDIPRAGVEYGQLLAVLPLQRMLPAGDGHPVLVLPGLLAGDGSTWILRRILRRLGYAAYGWGLGRNIGPTAKAVSGMRDLLDKLHSRYHTPVSLIGWSLGGIFARGLARDHPSAVRQVITLGSPFGMRDTCETRSAWSFNRYAHLHTERHELPLEMESEPLPVPTTAIYSRCDGMVAWQTCMNSPSERAENIAVRSSHIGYGHNPPVVWAIADRLAQPQGAWAPFRPPKVLSPLFPRPDTPAEAVSTPQTRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y3B4</accession>
    <name>A0A7U8Y3B4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="220" mass="20495" checksum="6A138113786586A7" modified="2021-06-02" version="1">MRKYLRANRGELTLMAIVNRFNIKVIAGAGLFAAAIALSPDAAADPLMTGGYACIQGMAGDAPVAAGDPVAAGGPAAAGACSAALTDMAGVPFVAPGPVPAAAPVPIGAPVPIPGAPVPIPGAPVPIPGAPVPIPGGPVPIPGAPVPVPAVPAPVIPVGTPLIALGPVLAGAPGDGVVSAPIIGMSGVKDALTDPAPAGGPVPGQPVLPGPSASAPAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y445</accession>
    <name>A0A7U8Y445_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="238" mass="25123" checksum="97F6265F412A6C9C" modified="2021-06-02" version="1">MEAGRADIVAPSHRWGLGAFLVVELVFLVASTSLAVVLTGHGPVSAGVLALALAAPTVVAAGLAILITRLRGNGPRTDLRLRWSWRGLRLGLMFGFGGMLVTIPASLVYTAIVGPEANSAVVRIFGGVRASWPWALVVFLVVVFVAPLCEEIIYRGLLWGAVDRRWGRWAALVVTTVVFALAHLEFARAPLLVVVAIPIALARFYSGGLLASIVTHQVTNLLPGIVLLLGLTGAISLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y494</accession>
    <name>A0A7U8Y494_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898592.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y494"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="115" mass="12512" checksum="2C68CCB3E6D744FD" modified="2021-06-02" version="1">MALKVEMVTFDCSDPAKLAGWWAEQFDGTTRELLPGEFVVVARTDGPRLGFQKVPDPAPGKNRVHLDFTTKDLDAEVLRLVAAGASEVGRHQVGESFRWVVLADPEGNAFCVAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4A9</accession>
    <name>A0A7U8Y4A9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02739</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="128" mass="14135" checksum="084D3DE4E8CB12D1" modified="2021-06-02" version="1">MGAWQTADTMGIFQALPDVWGGWRTECWEDRFEEQLIRCNGALRLPELDLAAGMDSAREWLRDRIFQRFSDSPAGQILKLSELLADVGPGLVVSDDAVTNGGARPNNEEWARFVAACDLVRGAHAESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4D7</accession>
    <name>A0A7U8Y4D7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03067</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404735.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4D7"/>
    <dbReference type="GeneID" id="45424874"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="139"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="257" mass="27627" checksum="26BDB284D9C27AFD" modified="2021-06-02" version="1">MPTRSSAPLGAPCWIDLTTSDVDRAQDFYGTVFGWAFESAGPDYGGYINAAKGGHPVAGLMANRPEFQSPDGWATYFHTVDIGATVAKLAAAGGSSCLDPMEVPGKGFMSLAVDPSGAAFGLWQPLQHHGFEVIGEAGSPVWHQLTTRDYRSVIDFYRQVFGWRTEQISDTDEFCYTTAWFDDQQLLGVMDGSSCLPEGVPSNWTIFFGAEDVDETLRVICDNGGSVVRAAENTPYGRLAAAADPMGVVFNLSSLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4E0</accession>
    <name>A0A7U8Y4E0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403465.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4E0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="265" mass="28575" checksum="7E96AFD7EC608067" modified="2021-06-02" version="1">MLARYIKMQLLVLLCGGLVGPIFLVVYFTLGLGSLMSWMFYVGLIITVADVLVALALTNYGAKTAAKTAALERSGVLALAQITGLSETGTRINDQPLVKVHLHISGPGITPFDTEDRVIASVTRLGNLTARKLVVLVNPATQQYLIDWERSALVNGLVPAQFTVAEDNKTYDLSGQTGPLMEILQILKANNVPLNRMVDIRSNPALRQQVQAVVRRAAERQAPAAEPASQGSIAERLAELESLRASGAVNAAEYESKRAQIISEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4G7</accession>
    <name>A0A7U8Y4G7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="194"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="426" mass="44263" checksum="E9073D50DEF9B40A" modified="2021-06-02" version="1">MRSVEEQQARISAAAVAPRPIRVAIAEAQGLMCAEEVVTERPMPGFDQAAIDGYAVRSVDVAGVGDTGGVQVFADHGDLDGRDVLTLPVMGTIEAGARTLSRLQPRQAVRVQTGAPLPTLADAVLPLRWTDGGMSRVRVLRGAPSGAYVRRAGDDVQPGDVAVRAGTIIGAAQVGLLAAVGRERVLVHPRPRLSVMAVGGELVDISRTPGNGQVYDVNSYALAAAGRDAGAEVNRVGIVSNDPTELGEIVEGQLNRAEVVVIAGGVGGAAAEAVRSVLSELGEMEVVRVAMHPGSVQGFGQLGRDGVPTFLLPANPVSALVVFEVMVRPLIRLSLGKRHPMRRIVSARTLSPITSVAGRKGYLRGQLMRDQDSGEYLVQALGGAPGASSHLLATLAEANCLVVVPTGAEQIRTGEIADVAFLAQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4Q1</accession>
    <name>A0A7U8Y4Q1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="6">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rsmA</name>
        <name evidence="6" type="synonym">ksgA</name>
        <name evidence="10" type="ORF">TBLG_03174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="6"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405191.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4Q1"/>
    <dbReference type="GeneID" id="45424982"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="rADc" evidence="9">
        <location>
            <begin position="44"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="317" mass="34646" checksum="40C58A1CD1EB69DE" modified="2021-06-02" version="1">MCCTSGCALTIRLLGRTEIRRLAKELDFRPRKSLGQNFVHDANTVRRVVAASGVSRSDLVLEVGPGLGSLTLALLDRGATVTAVEIDPLLASRLQQTVAEHSHSEVHRLTVVNRDVLALRREDLAAAPTAVVANLPYNVAVPALLHLLVEFPSIRVVTVMVQAEVAERLAAEPGSKEYGVPSVKLRFFGRVRRCGMVSPTVFWPIPRVYSGLVRIDRYETSPWPTDDAFRRRVFELVDIAFAQRRKTSRNAFVQWAGSGSESANRLLAASIDPARRGETLSIDDFVRLLRRSGGSDEATSTGRDARAPDISGHASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4Q2</accession>
    <name>A0A7U8Y4Q2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar-binding lipoprotein lpqY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898783.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4Q2"/>
    <dbReference type="GeneID" id="45425205"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006059">
        <property type="entry name" value="SBP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01547">
        <property type="entry name" value="SBP_bac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031115479" evidence="1">
        <location>
            <begin position="25"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="468" mass="49793" checksum="D2F5A20A706680CA" modified="2021-06-02" version="1">MVMSRGRIPRLGAAVLVALTTAAAACGADSQGLVVSFYTPATDGATFTAIAQRCNQQFGGRFTIAQVSLPRSPNEQRLQLARRLTGNDRTLDVMALDVVWTAEFAEAGWALPLSDDPAGLAENDAVADTLPGPLATAGWNHKLYAAPVTTNTQLLWYRPDLVNSPPTDWNAMIAEAARLHAAGEPSWIAVQANQGEGLVVWFNTLLVSAGGSVLSEDGRHVTLTDTPAHRAATVSALQILKSVATTPGADPSITRTEEGSARLAFEQGKAALEVNWPFVFASMLENAVKGGVPFLPLNRIPQLAGSINDIGTFTPSDEQFRIAYDASQQVFGFAPYPAVAPGQPAKVTIGGLNLAVAKTTRHRAEAFEAVRCLRDQHNQRYVSLEGGLPAVRASLYSDPQFQAKYPMHAIIRQQLTDAAVRPATPVYQALSIRLAAVLSPITEIDPESTADELAAQAQKAIDGMGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4X4</accession>
    <name>A0A7U8Y4X4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar-transport membrane protein ABC transporter sugB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03414</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900298.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4X4"/>
    <dbReference type="GeneID" id="45425207"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="274" mass="29158" checksum="772A9A53F559332C" modified="2021-06-02" version="1">MGARRATYWAVLDTLVVGYALLPVLWIFSLSLKPTSTVKDGKLIPSTVTFDNYRGIFRGDLFSSALINSIGIGLITTVIAVVLGAMAAYAVARLEFPGKRLLIGAALLITMFPSISLVTPLFNIERAIGLFDTWPGLILPYITFALPLAIYTLSAFFREIPWDLEKAAKMDGATPGQAFRKVIVPLAAPGLVTAAILVFIFAWNDLLLALSLTATKAAITAPVAIANFTGSSQFEEPTGSIAAGAIVITIPIIVFVLIFQRRIVAGLTSGAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y523</accession>
    <name>A0A7U8Y523_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <shortName evidence="11">AdoMet synthase</shortName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">metK</name>
        <name evidence="17" type="ORF">TBLG_03579</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 13">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900333.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y523"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10 11 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-AdoMet_synt_N" evidence="14">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_M" evidence="15">
        <location>
            <begin position="130"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="S-AdoMet_synt_C" evidence="16">
        <location>
            <begin position="253"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="11">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="179"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="265"/>
            <end position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFD12995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="403" mass="43047" checksum="2E18BE05D8267972" modified="2021-06-02" version="1">MSEKGRLFTSESVTEGHPDKICDAISDSVLDALLAADPRSRVAVETLVTTGQVHVVGEVTTSAKEAFADITNTVRARILEIGYDSSDKGFDGATCGVNIGIGAQSPDIAQGVDTAHEARVEGAADPLDSQGAGDQGLMFGYAINATPELMPLPIALAHRLSRRLTEVRKNGVLPYLRPDGKTQVTIAYEDNVPVRLDTVVISTQHAADIDLEKTLDPDIREKVLNTVLDDLAHETLDASTVRVLVNPTGKFVLGGPMGDAGLTGRKIIVDTYGGWARHGGGAFSGKDPSKVDRSAAYAMRWVAKNVVAAGLAERVEVQVAYAIGKAAPVGLFVETFGTETEDPVKIEKAIGEVFDLRPGAIIRDLNLLRPIYAPTAAYGHFGRTDVELPWEQLDKVDDLKRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7D8</accession>
    <name>A0A7U8Y7D8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416110.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7D8"/>
    <dbReference type="GeneID" id="45427097"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="106" mass="11859" checksum="D4DFC3D3F8CC9DA1" modified="2021-06-02" version="1">MVIRGAVYRVDFGDAKRGHEQRGRRYAVVISPGSMPWSVVTVVPTSTSAQPAVFRPELEVMGTKTRFLVDQIRTIGIVYVHGDPVDYLDRDQMAKVEHAVARYLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7F5</accession>
    <name>A0A7U8Y7F5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase subunit I L nuoL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03778</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900642.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7F5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="74"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="140"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD14880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="633" mass="66168" checksum="0ED0FC1C3F12FE3D" modified="2021-06-02" version="1">MTTSLGTHYTWLLVALPLAGAAILLFGGRRTDAWGHLLGCAAALAAFGVGAMLLADMLGRDGLERAIHQQVFTWIPAGGLQVDFGLQIDQLSMCFVLLISGVGSLIHIYSVGYMAEDPDRRRFFGYLNLFLASMLLLVVADNYVLLYVGWEGVGLASYLLIGFWYHKPSAATAAKKAFVMNRVGDAGLAVGMFLTFSTFGTLSYAGVFAGVPAASRAVLTAIGLLMLLGACAKSAQVPLQAWLGDAMEGPTPVSALIHAATMVTAGVYLIVRSGPLYNLAPTAQLAVVIVGAVTLLFGAIIGCAKDDIKRALAASTISQIGYMVLAAGLGPAGYAFAIMHLLTHGFFKAGLFLGSGAVIHAMHEEQDMRRYGGLRAALPVTFATFGLAYLAIIGVPPFAGFFSKDAIIEAALGAGGIRGSLLGGAALLGAGVTAFYMTRVMLMTFFGEKRWTPGAHPHEAPAVMTWPMILLAVGSVFSGGLLAVGGTLRHWLQPVVGSHEEATHALPTWVATTLALGVVAVGIAVAYRMYGTAPIPRVAPVRVSALTAAARADLYGDAFNEEVFMRPGAQLTNAVVAVDDAGVDGSVNALATLVSQTSNRLRQMQTGFARNYALSMLVGAVLVAAALLVVQLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7H3</accession>
    <name>A0A7U8Y7H3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416863.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427201"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021456">
        <property type="entry name" value="DUF3107"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11305">
        <property type="entry name" value="DUF3107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="90" mass="9433" checksum="417AE0D5B87F2985" modified="2021-06-02" version="1">MEVKIGITDSPRELVFSSAQTPSEVEELVSNALRDDSGLLTLTDERGRRFLIHTARIAYVEIGVADARRVGFGVGVDAAAGSAGKVATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7I1</accession>
    <name>A0A7U8Y7I1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical alanine, arginine and proline rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045596">
        <property type="entry name" value="DUF6459"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20060">
        <property type="entry name" value="DUF6459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="213" mass="22658" checksum="1C64EEE9DE578954" modified="2021-06-02" version="1">MMASNQTAAQHSSATLQQAPRSIDDAGGCPLTISPIANSPGDTFAVTPVVEYEPPPRNIPPCGQSSHAARRPHTPQLARRQPIRPSGRAPAAVTSTAKSPRLRQAGTFADAALRRVLEVIDRRRPVGQLRPLLAPGLVDSVLAVSRTAAGHQQGAAMLRRIRLTPAGPDTADTAAEVFGTYSRGDRIHAIACRVEQRPAGNETRWLMVALHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7J4</accession>
    <name>A0A7U8Y7J4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fade25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03913</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417122.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7J4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="17"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="131"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="238"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="389" mass="41723" checksum="2E77D0F28A9C8E08" modified="2021-06-02" version="1">MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEEALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILNGAKCWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDLGFISAASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7P9</accession>
    <name>A0A7U8Y7P9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7P9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="438" mass="47726" checksum="C6CF7F270A4FB68B" modified="2021-06-02" version="1">MHFARHGAGIQHPVIVRGDGVTIFDDRGKSYLDALSGLFVVQVGYGRAELAEAAARQAGTLGYFPLWGYATPPAIELAERLARYAPGDLNRVFFTSGGTEAVETAWKVAKQYFKLTGKPGKHKVISRSIAYHGTTQGALAITGLPLFKAPFEPLTPGGFRVPNTNFYRAPLHTDLKEFGRWAADRIAEAIEFEGPDTVAAVFLEPVQNAGGCIPAPPGYFERVREICDRYDVLLVSDEVICAFGRIGSMFACEDLGYVPDMITCAKGLTSGYSPLGAMIASDRLFEPFNDGETMFAHGYTFGGHPVSAAVGLANLDIFEREGLSDHVKRNSPALRATLEKLYDLPIVGDIRGEGYFFGIELVKDQATKQTFTDDERARLLGQVSAALFEAGLYCRTDDRGDPVVQVAPPLISGQPEFDTIETILRSVLTDTGRKYLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7S1</accession>
    <name>A0A7U8Y7S1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_04134</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900866.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7S1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_cpsA_psr" evidence="4">
        <location>
            <begin position="109"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="5">
        <location>
            <begin position="379"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="512" mass="54355" checksum="564614D425321D1B" modified="2021-06-02" version="1">MARSEGNRPRHRAVPQPSRIRKRLSRGVMTLVSVVALLMTGAGYWVAHGALGGITISQALTPEDPRSSGNNMNILLIGLDSRKDQEGNDLPWSVLKQLHAGDSDDGGYNTNTLILVHVGADGKVVAFSIPRDDWVPFTGVPGYNHIKIKEAYGLTKQYVAEQLANQGVSDRKELETRGREAARAATLRAVRSLTGVPIDYFAEINLAGFYDLAQTLGGVDVCLNHAVYDSYSGADFPAGRQRLNAAQALAFVRQRHGLDNGDLDRTHRQQAFLSSVMRELQDSGTFTNLDRLDNLMAVARKDVVLSAGWDEDLFRRMGDLAGGNVEFRTLPVVRYDNIDGQDVNIIDPTAIRAEVAAAFGSAPPTSQTAAAAKPNPSTVVDVVNAGSISGLASQVSGALLKRGYTAGQVRDRESGDPFTTAIEYGAGAETDAQNVADLLGIDAPNHPDPAVAPGHIRVTVDTNFSLPAPDEATAAATSTETSTYPLYGGGTTTDPTPDQGAPIDGGGVPCVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7V3</accession>
    <name>A0A7U8Y7V3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ftsE</name>
        <name evidence="8" type="ORF">TBLG_03723</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416120.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7V3"/>
    <dbReference type="GeneID" id="45427101"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="2"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="229" mass="25596" checksum="2F6BF50728761AA0" modified="2021-06-02" version="1">MITLDHVTKQYKSSARPALDDINVKIDKGEFVFLIGPSGSGKSTFMRLLLAAETPTSGDVRVSKFHVNKLRGRHVPKLRQVIGCVFQDFRLLQQKTVYDNVAFALEVIGKRTDAINRVVPEVLETVGLSGKANRLPDELSGGEQQRVAIARAFVNRPLVLLADEPTGNLDPETSRDIMDLLERINRTGTTVLMATHDHHIVDSMRQRVVELSLGRLVRDEQRGVYGMDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y806</accession>
    <name>A0A7U8Y806_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-quinone oxidoreductase subunit A</fullName>
            <ecNumber evidence="6">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NADH dehydrogenase I subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NDH-1 subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">NUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoA</name>
        <name evidence="8" type="ORF">TBLG_03766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cell membrane</location>
            <topology evidence="6 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416417.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y806"/>
    <dbReference type="GeneID" id="45427132"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-0520">NAD</keyword>
    <keyword evidence="6 7" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="128" mass="13975" checksum="DDF4FD3F77A8149A" modified="2021-06-02" version="1">MNVYIPILVLAALAAAFAVVSVVIASLVGPSRFNRSKQAAYECGIEPASTGARTSIGPGAASGQRFPIKYYLTAMLFIVFDIEIVFLYPWAVSYDSLGTFALVEMAIFMLTVFVAYAYVWRRGGLTWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y872</accession>
    <name>A0A7U8Y872_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418301.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y872"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="103" mass="10672" checksum="52F631F8DB585AD0" modified="2021-06-02" version="1">MRPDSVNSAGIDIAAVYAVADRFSAAAELIDDAIGNHLTRLAFGGACAGRGHASRGDALRCRLDRLAGELSVWSRAAVQIAFALRAGANRYAEADLCAAARIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y8D0</accession>
    <name>A0A7U8Y8D0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Esterase/lipase lipF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="3">
        <location>
            <begin position="6"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="223" mass="23597" checksum="2595EC3EA58A357F" modified="2021-06-02" version="1">SLSIRWGMALDDCHDAYQWLRARGYRPEQIVLAGDSAGGYLCARACAAAAVRRRETGGNSGHLSVAAAGKGPKQDHPNIGTDAMFPARAFDALAAWVRAAAAKNMVDGRPEDLYEPLDHIESSLPPTLIHVSGSEVLLHDAQLGAGKLAAAGVCAEVRVWPGQAHLFQLATPLVPEATRSLRQIGQFIRDATADSSLSPVHRSRYVAGSPRAASRGAFGQSPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9V8</accession>
    <name>A0A7U8Y9V8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fe(III)-dicitrate-binding periplasmic lipoprotein fecB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03664</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415959.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y9V8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002491">
        <property type="entry name" value="ABC_transptr_periplasmic_BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01497">
        <property type="entry name" value="Peripla_BP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50983">
        <property type="entry name" value="FE_B12_PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030993026" evidence="2">
        <location>
            <begin position="29"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Fe/B12 periplasmic-binding" evidence="3">
        <location>
            <begin position="91"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="359" mass="36910" checksum="50C08029AE99530F" modified="2021-06-02" version="1">MRSTVAVAVAAAVIAASSGCGSDQPAHKASQSMITPTTQIAGAGVLGNDRKPDESCARAAAAADPGPPTRPAHNAAGVSPEMVQVPAEAQRIVVLSGDQLDALCALGLQSRIVAAALPNSSSSQPSYLGTTVHDLPGVGTRSAPDLRAIAAAHPDLILGSQGLTPQLYPQLAAIAPTVFTAAPGADWENNLRGVGAATARIAAVDALITGFAEHATQVGTKHDATHFQASIVQLTANTMRVYGANNFPASVLSAVGVDRPPSQRFTDKAYIEIGTTAADLAKSPDFSAADADIVYLSCASEAAAERAAVILDSDPWRKLSANRDNRVFVVNDQVWQTGEGMVAARGIVDDLRWVDAPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA40</accession>
    <name>A0A7U8YA40_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416790.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="74" mass="7983" checksum="410F47E6627A2B92" modified="2021-06-02" version="1">MLRNGSSTVVRRAPTANRDAAGGGIKMPPPAAPDAPVQRPDYSETDWDALRAAYPRDAERVKRAMFIVSAATEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA57</accession>
    <name>A0A7U8YA57_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bifunctional AAC/APH</fullName>
            <ecNumber evidence="4">2.7.1.190</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03859</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region. The C-terminal region is a kinase that phosphorylates several 4,6-disubstituted aminoglycosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a gentamycin + GTP = a gentamycin 2''-phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48872"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:90218"/>
            <dbReference type="ChEBI" id="CHEBI:90219"/>
            <dbReference type="EC" id="2.7.1.190"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.190" evidence="4"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="7">
        <location>
            <begin position="15"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="474" mass="51324" checksum="6407B3285CA2A84F" modified="2021-06-02" version="1">MRFAKLSDGLSDGIVTLSPLCLDDVDAHLAGGDERLVRWLSGMPSTRASVEAYIRHCREQWVTGGPLRSFGIRTVAETIVGTIDLRFDGEGLASGQVNVAYGLYPSWRGRGLATRAVDLVRQYAAEHGATEAVIKVEPENSASARVALRAGFAFVRRICEQDGTVFDRYERVLRAKMHADEVDIDEDLVRRLLRAQFPQWADLPIAPVRSAGTDNAMYRLGEDLAVRIPRIGWAIESLRTEQQWLPRIAAHLGVASPVPVGLGSPAEGFGWPWSVCRWVAGENPSAAEFVEPNRAVEDLADFITALRATDPMGGPPAKRGAPLGEQDAEVRAALAALDGIIDVHAATAAWESALRVPPYAGPPMWFHGDLSRFNILTAQGRLTGVIDFGLMGVGDPSVDLIIAWNLLSAPARAQFRVAVGAADDDWMRGRGRALAIALIALPYYQDTNPPLAASARYAIGEVLADFRYGARPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA85</accession>
    <name>A0A7U8YA85_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417286.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA85"/>
    <dbReference type="GeneID" id="45427321"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="80" mass="8850" checksum="EBCAF8D6A242D29B" modified="2021-06-02" version="1">MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF18</accession>
    <name>A0A7U8TF18_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="548" mass="54974" checksum="1525AA90290C1827" modified="2021-06-02" version="1">MDVALGVAVTDRVARLALVDSAAPGTVIDQFVLDVAEHPVEVLTETVVGTDRSLAGENHRLVATRLCWPDQAKADELQHALQDSGVHDVAVISEAQAATALVGAAHAGSAVLLVGDETATLSVVGDPDAPPTMVAVAPVAGADATSTVDTLMARLGDQALAPGDVFLVGRSAEHTTVLADQLRAASTMRVQTPDDPTFALALGAAMAAGAATMAHPALVADATTSLPPAEAGQSGSEGEQLAYSQASDYELLPVDEYEEHDEYGAAADRSAPLSRRSLLIGNAVVAFAVIGFASLAVAVAVTIRPTAASKPVEGHQNAQPGKFMPLLPTQQQAPVPPPPPDDPTAGFQGGTIPAVQNVVPRPGTSPGVGGTPASPAPEAPAVPGVVPAPVPIPVPIIIPPFPGWQPGMPTIPTAPPTTPVTTSATTPPTTPPTTPVTTPPTTPPTTPVTTPPTTPPTTPVTTPPTTVAPTTVAPTTVAPTTVAPTTVAPATATPTTVAPQPTQQPTQQPTQQMPTQQQTVAPQTVAPAPQPPSGGRNGSGGGDLFGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF25</accession>
    <name>A0A7U8TF25_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402907.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF25"/>
    <dbReference type="GeneID" id="45424510"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="3"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="128" mass="14346" checksum="E6932EE3B7F67CF3" modified="2021-06-02" version="1">MEILASRMLLRPADYQRSLSFYRDQIGLAIAREYGAGTVFFAGQSLLELAGYGEPDHSRGPFPGALWLQVRDLEATQTELVSRGVSIAREPRREPWGLHEMHVTDPDGITLIFVEVPEGHPLRTDTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF64</accession>
    <name>A0A7U8TF64_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_02717</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="609"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="686"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="740"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="766"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="793" mass="83793" checksum="A80A145DD95A03B6" modified="2021-06-02" version="1">MRVDGRDIGVSGNLLQPLTRRTNDIIRAVLAAIYLVAVITSSLITRPQWVALEKSISEIVGVLSPSQSDLVYLGYGLAILALPFVILIGLIVSRQWKLLGAYAAAGLMAVLPLSISSSRIAAPRWHFDLSDRLATLLAQFLDDPRWIAMLAAVLTVSGPWLPARWRHWWWALLLAFVPIHLVVSAIVPARSLLGLAVGWLVGALVVLVVGTPALEVPLDGAIRALAKRGFAVSGLAVVRPAGPGPLVLSAACEQPNAGACSEALIELYGPHQSGGGALRQLWLKLTLRGTETAPLQASMRRAVEHRALMAIAFGDLGMANTTVIAVSPLDRGWTLYAHRPARGIGISECTKTTPTAHVWEALRTLHDQQISHGDLCSAEITVDNGAVLFGGFGEAEYGATDAQLQSDLAQLLVTTSALYDAEAAVTAAIDTFGKQAILAASRRLTKSAVPKRIRESITDPNAVIASTRAEVMRQTGADQIKAETITRFSRGQLIQLVLIGALVYVAYPFISTVPTFFSQLRTANWWWALLGLAVSALTYVGAAAALWACADGLVGFWKLSIMQVANTFAATTTPAGVGGLALSTRFLQKGGLTAVRATAAVALQQSVQVIVHLVLLILFSALAGTSTDLSHFVPNATVLYLIAGVALGIVGHSLRAELRRWLATRASKLREVTNDLIALAREPKRLALIVLGCAGTTLGAALALWASIEAFGGGTTFVTVTVVTMVGGTLASAAPTPGGVGAVEAALIGGLAAFGVPAALGVPSVLLYRLLTCWLPVFAGWQVMHWLTRHEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFB0</accession>
    <name>A0A7U8TFB0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02792</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="PTHR10543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="458" mass="50154" checksum="5558C1D97E846363" modified="2021-06-02" version="1" fragment="single">MTTAQAAESQNPYLEGFLAPVSTEVTATDLPVTGRIPEHLDGRYLRNGPNPVAEVDPATYHWFTGDAMVHGVALRDGKARWYRNRWVRTPAVCAALGEPISARPHPRTGIIEGGPNTNVLTHAGRTLALVEAGVVNYELTDELDTVGPCDFDGTLHGGYTAHPQRDPHTGELHAVSYSFARGHRVQYSVIGTDGHARRTVDIEVAGSPMMHSFSLTDNYVVIYDLPVTFDPMQVVPASVPRWLQRPARLVIQSVLGRVRIPDPIAALGNRMQGHSDRLPYAWNPSYPARVGVMPREGGNEDVRWFDIEPCYVYHPLNAYSECRNGAEVLVLDVVRYSRMFDRDRRGPGGDSRPSLDRWTINLATGAVTAECRDDRAQEFPRINETLVGGPHRFAYTVGIEGGFLVGAGAALSTPLYKQDCVTGSSTVASLDPDLLIGEMVFVPNPSARAEDDGILMGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFG3</accession>
    <name>A0A7U8TFG3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="304" mass="30278" checksum="B2140CEF883E7D79" modified="2021-06-02" version="1">MLTLCLDIGGTKIAAGLADPAGTLVHTAQRPTPAYGGAEQVWAAVAEDDRRRARRGGGRGRWCGDRLRPVLFDPTQRAGSSPINIGSWGGFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGRGARFLLGLVVSTGVGGGLVLDGAPCLGRTGNAGHVGHVVVDPDGSPCPCGGRGCVETIASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALAAMIASVGAVCDLDLAVIGGGVAKSGRLLFEPLRAALADHARLDFLAGLRVVPAELGGAAGLVGAARLAAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFJ9</accession>
    <name>A0A7U8TFJ9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 123 cyp123</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02912</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFJ9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="402" mass="45421" checksum="76AD843019361798" modified="2021-06-02" version="1">MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNFWAVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGFTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDRARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAELDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWVEETLRYDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGFAHLPISVQAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFL5</accession>
    <name>A0A7U8TFL5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">map</name>
        <name evidence="5" type="ORF">TBLG_02878</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403728.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFL5"/>
    <dbReference type="GeneID" id="45424699"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="266" mass="27277" checksum="A187BD61E62449E1" modified="2021-06-02" version="1">MRPLARLRGRRVVPQRSAGELDAMAAAGAVVAAALRAIRAAAAPGTSSLSLDEIAESVIRESGATPSFLGYHGYPASICASINDRVVHGIPSTAEVLAPGDLVSIDCGAVLDGWHGDAAITFGVGALSDADEALSEATRESLQAGIAAMVVGNRLTDVAHAIETGTRAAELRYGRSFGIVAGYGGHGIGRQMHMDPFLPNEGAPGRGPLLAAGSVLAIEPMLTLGTTKTVVLDDKWTVTTADGSRAAHWEHTVAVTDDGPRILTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFS7</accession>
    <name>A0A7U8TFS7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404312.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFS7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="258" mass="28061" checksum="F15294F2730CD75B" modified="2021-06-02" version="1">MAKRLDLTDVNIYYGSFHAVADVSLAILPRSVTAFIGPSGCGKTTVLRTLNRMHEVIPGARVEGAVLLDDQDIYAPGIDPVGVRRAIGMVFQRPNPFPAMSIRNNVVAGLKLQGVRNRKVLDDTAESSLRGANLWDEVKDRLDKPGGGLSGGQQQRLCIARAIAVQPDVLLMDEPCSSLDPISTMAIEDLISELKQQYTIVIVTHNMQQAARVSDQTAFFNLEAVGKPGRLVEIASTEKIFSNPNQKATEDYISGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFW3</accession>
    <name>A0A7U8TFW3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="4">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404742.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFW3"/>
    <dbReference type="GeneID" id="45424877"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="PTHR10543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="502" mass="56639" checksum="43F9861F1DC44F87" modified="2021-06-02" version="1">MDITIVGKYLSTLPEDDDHPYRTGPWRPQTTEWDADDLTTVTGEVPADLDGIYLRNTENPLHPAFATYHPFDGDGMIHVVGFRDGKAFYRNRFIRTDGFLAENEAGGPLWPGLAEPVQLAKREHGWGARGLMKDASSTDVIVHRGIALTSFYQCGDLYRIDPYSANTLGKESWHGRFPFDWGVSAHPKVDNKTGELLFFNYSKQEPYMRYGVVDQNNELVHYVDVPLPGPRLPHDMAFTENYVILNDFPLFWDPRLLERDVHLPRFYPEIPSRFAVVARRGNDIRWFEADPTFVLHFTNAYEQGDEIVLDGFYEGDPQPLDTGGTKWEKLFRFLALDRLQSRLHRWRLNMVTGAVHEEQLSESITEFGTINADYAASSYRYTYAATGKPSWFLFDGLVKHDLLTGNHECYSFGDGVYGSETAMAPRVGSSAEDDGYLVTLTTDMNDDASYCLVFDAARPGDGPICKLALPERISSGTHSAWVPGAELRRWDHAESPAAAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFW9</accession>
    <name>A0A7U8TFW9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901038.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFW9"/>
    <dbReference type="GeneID" id="45424852"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="SSF56219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030694043" evidence="2">
        <location>
            <begin position="32"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Endo/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="228"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="490" mass="52034" checksum="8A6DEA5E95A3D26E" modified="2021-06-02" version="1">MDYAKRIGQVGALAVVLGVGAAVTTHAIGSAAPTDPSSSSTDSPVDACSPLGGSASSLAAIPGASVPQVGVRQVDPGSIPDDLLNALIDFLAAVRNGLVPIIENRTPVANPQQVSVPEGGTVGPVRFDACDPDGNRMTFAVRERGAPGGPQHGIVTVDQRTASFIYTADPGFVGTDTFSVNVSDDTSLHVHGLAGYLGPFHGHDDVATVTVFVGNTPTDTISGDFSMLTYNIAGLPFPLSSAILPRFFYTKEIGKRLNAYYVANVQEDFAYHQFLIKKSKMPSQTPPEPPTLLWPIGVPFSDGLNTLSEFKVQRLDRQTWYECTSDNCLTLKGFTYSQMRLPGGDTVDVYNLHTNTGGGPTTNANLAQVANYIQQNSAGRAVIVTGDFNARYSDDQSALLQFAQVNGLTDAWVQVEHGPTTPPFAPTCMVGNECELLDKIFYRSGQGVTLQAVSYGNEAPKFFNSKGEPLSDHSPAVVGFHYVADNVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG12</accession>
    <name>A0A7U8TG12_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03135</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898670.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG12"/>
    <dbReference type="GeneID" id="45424943"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="123"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="382" mass="40747" checksum="3FA5C8A897E8634A" modified="2021-06-02" version="1">MNIWTTPERQQLRKTVRAFAEREILPHVDEWERIGELPRGLHRLAGAAGLLGAGFPEAVGGGGGDGADPVIICEEMHQAGAPGGVYASLFTCGIAVPHMVASGDERLIATYVRPTLAGEKIGALAITEPGGGSDVGHLRTSAVRDGDHYVINGAKTYITSGVRADYVVTAVRTGGPGAAGVSLLVVEKDTPGFEVTRKLDKMGWRSSDTAELCYTDVAVPATNLVGAENSGFTQIARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRPLISRQSVQNTLAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNTAVQAGEWVANQAVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTALAAKTLGYQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG20</accession>
    <name>A0A7U8TG20_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pterin-4-alpha-carbinolamine dehydratase moaB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405127.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG20"/>
    <dbReference type="GeneID" id="45424953"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="28"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="181" mass="18441" checksum="DADE84BE56B63E5E" modified="2021-06-02" version="1">MKVAAQCSKLGYTVAPMEQRAELVVGRALVVVVDDRTAHGDEDHSGPLVTELLTEAGFVVDGVVAVSADEVEIRNALNTAVIGGVDLVVSVGGTGVTPRDVTPEATRDILDREILGIAEAIRASGLSAGIVDAGLSRGLAGVSGSTLVVNLAGSRYAVRDGMATLNPLAAQIIGQLSSLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG27</accession>
    <name>A0A7U8TG27_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved serine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405142.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424960"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="110" mass="11458" checksum="EA67B53F75E7A6A2" modified="2021-06-02" version="1">MPTYSYECTQCANRFDVVQAFTDDALTTCERCSGRLRKLFNAVGVVFKGTGFYRTDSRESGKKSKSQTNGSSTSESTKSSGSSGSSGSSESKASGSTEKSTSSTTAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG65</accession>
    <name>A0A7U8TG65_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="91" mass="10326" checksum="332760868DFC9EF6" modified="2021-06-02" version="1">MDSHKVCMNNNTQLPTGPIIGVHPAVRDGVERVAYLDGDLLRCNTDVEFTSSPPPGPVLYRTKHTRVEIADEMVTEKLIKRQRAFNSRRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG73</accession>
    <name>A0A7U8TG73_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405651.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG73"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="131" mass="14033" checksum="F4D0F5AA6C72B797" modified="2021-06-02" version="1">MSRIDRVLEAARRRYRRLAADQVPEAARRGAVLVDIRPQAQRAREGEVPGALVIERNVLEWRCDPTSDARLPQAVDDDVEWVILCSEGYTSSLAAASLLDLGLHRATDVVGGYRALAAGGVLAELGGAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGA0</accession>
    <name>A0A7U8TGA0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405749.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="88" mass="9296" checksum="86787F92D7A81596" modified="2021-06-02" version="1">MNQILLSVIAEGGPGNTGPDFGKASPVGLLVIVLLVIATLFLVRSMNQQLKKVPKSFDRDHPELDQAADEGTDRDGPARPPGPPHESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGA4</accession>
    <name>A0A7U8TGA4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901093.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425089"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="61" mass="7296" checksum="52040381E0F474D0" modified="2021-06-02" version="1">MCSRMADEPRLEAGAHPFEEGRDKAPELRATQMDHVRFTEGRRERNRDRLERSQQFRQPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGE8</accession>
    <name>A0A7U8TGE8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406197.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_30" evidence="1">
        <location>
            <begin position="475"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="538" mass="57503" checksum="6C50FB0979342F0A" modified="2021-06-02" version="1">MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSDDVRLGLAAAAGSADVFFLIGVTDDEAVRWVDDQARQRAPVAIFVKHPSDSVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDLFGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPEHLQWIGQWGIFDALRAGREVVRVAERPELGLRPRLAIGIHQPGVGALRPPVFAGTIWVQQGSQPLADDAEEMLRGAAVLAARIMSRLATQPNTHALRVQQLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAVRHVRLVDVMALSASAFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGTISALRAELGVALRAAIAGPVAGLAEVNPARVEVDRVLESAERHPILGQVTSLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLGAQDPVLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGDPDVRLLFSLGLRAMERTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGF9</accession>
    <name>A0A7U8TGF9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406195.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425155"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013228">
        <property type="entry name" value="PE-PPE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08237">
        <property type="entry name" value="PE-PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031443883" evidence="1">
        <location>
            <begin position="26"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="PE-PPE" evidence="2">
        <location>
            <begin position="79"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="359" mass="37818" checksum="85E0949ACD144560" modified="2021-06-02" version="1">MKRVIAGAFAVWLVGWAGGFGTAIAASEPAYPWAPGPPPSPSPVGDASTAKVVYALGGARMPGIPWYEYTNQAGSQYFPNAKHDLIDYPAGAAFSWWPTMLLPPGSHQDNMTVGVAVKDGTNSLDNAIHHGTDPAAAVGLSQGSLVLDQEQARLANDPTAPAPDKLQFTTFGDPTGRHAFGASFLARIFPPGSHIPIPFIEYTMPQQVDSQYDTNHVVTAYDGFSDFPDRPDNLLAVANAAIGAAIAHTPIGFTGPGDVPPQNIRTTVNSRGATTTTYLVPVNHLPLTLPLRYLGMSDAEVDQIDSVLQPQIDAAYARNDNWFTRPVSVDPVRGLDPLTAPGSIVEGARGLLGSPAFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGJ6</accession>
    <name>A0A7U8TGJ6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="319" mass="35285" checksum="0C3DE4DE6FF5F74D" modified="2021-06-02" version="1">MSDVKTVVVSGASVAGTAAAYWLGRHGYSVTMVERHPGLRPGGQAIDVRGPALDVLERMGLLAAAQEHKTRIRGASFVDRDGNELFRDTESTPTGGPVNSPDIELLRDDLVELLYGATQPSVEYLFDDSISTLQDDGDSVRVTFERAAAREFDLVIGADGLHSNVRRLVFGPEEQFVKRLGTHAAIFTVPNFLELDYWQTWHYGDSTMAGVYSARNNTEARAALAFMDTELRIDYRDTEAQFAELQRRMAEDGWVRAQLLHYMRSAPRRNVADPDGSLVAGQGSARWRRWLLLLALVGAGDQRRPAGCLHPGRRTQGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGK5</accession>
    <name>A0A7U8TGK5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03445</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026954">
        <property type="entry name" value="PknH-like_Extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038232">
        <property type="entry name" value="PknH-like_Extracell_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14032">
        <property type="entry name" value="PknH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="200"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="205"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="534" mass="56207" checksum="4D19550BE829F166" modified="2021-06-02" version="1">MRLVEGTDLDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPAPPKPVPPPTMPATAMAPRQPPAPPVTPPGVQPAPKPSYTPPAQPGPAGQRPGPTGQPSWAPNSGPMPASGPTPTPQYYQGGGWGAPPSGGPSPWAQTPRKTNPWPLVAGAAAVVLVLVLGAIGIWIAIRPKPVQPPQPVAEERLSALLLNSSEVNAVMGSSSMQPGKPITSMDSSPVTVSLPDCQGALYTSQDPVYAGTGYTAINGLISSEPGDNYEHWVNQAVVAFPTADKARAFVQTSADKWKNCAGKTVTVTNKAKTYRWTFADVKGSPPTITVIDTQEGAEGWECQRAMSVANNVVVDVNACGYQITNQAGQIAAKIVDKVNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGM6</accession>
    <name>A0A7U8TGM6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase rfe</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03484</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898816.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGM6"/>
    <dbReference type="GeneID" id="45425276"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="404" mass="42257" checksum="57D7D2807034A426" modified="2021-06-02" version="1">MQYGLEVSSDVAGVAGGLLALSYRGAGVPLRELALVGLTAAIITYFATGPVRMLASRLGAVAYPRERDVHVTPTPRMGGLAMFLGIVGAVFLASQLPALTRGFVYSTGMPAVLVAGAVIMGIGLIDDRWGLDALTKFAGQITAASVLVTMGVAWSVLYIPVGGVGTIVLDQASSILLTLALTVSIVNAMNFVDGLDGLAAGLGLITALAICMFSVGLLRDHGGDVLYYPPAVISVVLAGACLGFLPHNFHRAKIFMGDSGSMLIGLMLAAASTTAAGPISQNAYGARDVFALLSPFLLVVAVMFVPMLDLLLAIVRRTRAGRSAFSPDKMHLHHRLLQIGHSHRRVVLIIYLWVGIVAFGAASSIFFNPRDTAAVMLGAIVVAGVATLIPLLRRGDDYYDPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGN1</accession>
    <name>A0A7U8TGN1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="235" mass="24577" checksum="F1E2DD35E515A292" modified="2021-06-02" version="1" fragment="single">MAERFVVTGGNRLSGEVAVGGAKNSVLKLMAATLLAEGTSTITNCPDILDVPLMAEVLRGLGATVELDGDVARITAPDEPKYDADFAAVRQFRASVCVLGPLVGRCKRARVALPGGDAIGSRPLDMHQAGLRQLGAHCNIEHGCVVARAETLRGAEIQLEFPSVGATENILMAAVVAEGVTTIHNAAREPDVVDLCTMLNQMGAQVEGAGSPTMTITGVPRLHPTEHRVIGDRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGU8</accession>
    <name>A0A7U8TGU8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407318.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGU8"/>
    <dbReference type="GeneID" id="45425390"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="98"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="98"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD13016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="201" mass="21320" checksum="1CE1C3A20A61D2FF" modified="2021-06-02" version="1">MFTGIVEERGEVTGREALVDAARLTIRGPMVTADAGHGDSIAVNGVCLTVVDVLPDGQFTADVMAETLNRSNLGELRPGSRVNLERAAALGSRLGGHIVQGHVDATGEIVARCPSEHWEVVRIEMPASVARYVVEKGSITVDGISLTVSGLGAEQRDWFEVSLIPTTRELTTLGSAAVGTRVNLEVDVVAKYVERLMRSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGV3</accession>
    <name>A0A7U8TGV3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407264.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGV3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032687">
        <property type="entry name" value="AraC-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12625">
        <property type="entry name" value="Arabinose_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH araC/xylS-type" evidence="4">
        <location>
            <begin position="242"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="344" mass="37894" checksum="131FB83BC8C25EA7" modified="2021-06-02" version="1">MGHLPPPAEVRHPVYATRVLCEVANERGVPTADVLAGTAIEPADLDDPDAVVGALDEITAVRRLLARLPDDAGIGIDVGSRFALTHFGLFGFAVMSCGTLRELLTIAMRYFALTTMHVDITLFETADDCLVELDASHLPADVRGFFIERDIAGIIATTTSFALPLAAKYADQVSAELAVDAELLRPLLELVPVHDVAFGRAHNRVHFPRAMFDEPLPQADRHTLEMCIAQCDVLMQRNERRRGITALVRSKLFRDSGLFPTFTDVAGELDMHPRTLRRRLAEEGTSFRALLGEARSTVAVDLLRNVGLTVQQVSTRLGYTEVSTFSHAFKRWYGVAPSEYSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGW0</accession>
    <name>A0A7U8TGW0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TBLG_03597</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGW0"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="274"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD13013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="339" mass="35382" checksum="B3C277C8E1CF9772" modified="2021-06-02" version="1">MNVEQVKSIDEAMGLAIEHSYQVKGTTYPNPPVGAVIVDPNGRIVGAGGTEPAGGDHAEVVALRRAGGLATGAIVVVTMEPCNHYGKTPPCVNALIEARVGTVVYAVADPNGIAGGGAGRLSAAGLQVRSGVLAEQVAAGPLREWLHKQRTGLPHVTWKYATSIDGRSAAADGSSQWISSEAARLDLHRRRAIADAILVGTGTVLADDPALTARLADGSLAPQQPLRVVVGKRDIPPEARVLNDEARTMMIRTHEPMEVLRALSDRTDVLLEGGPTLAGAFLRAGAINRILAYVAPILLGGPVTAVDDVGVSNITNALRWQFDSVEKVGPDLLLSLVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGX0</accession>
    <name>A0A7U8TGX0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407359.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGX0"/>
    <dbReference type="GeneID" id="45425402"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD13028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="253" mass="27427" checksum="263080B9F837BED3" modified="2021-06-02" version="1">MTVVPGAPSRPASAVSRPSYRQCVQASAQTSARRYSFPSYRRPPAEKLVFPVLLGILTLLLSACQTASASGYNEPRGYDRATLKLVFSMDLGMCLNRFTYDSKLAPSRPQVVACDSREARIRNDGFHANAPSCMRIDYELITQNHRAYYCLKYLVRVGYCYPAVTTPGKPPSVLLYAPSACDESLPSPRVATALVPGTRSANREFSRFVVTEIKSLGAGGRCDSASVSLQPPEEIEGPAIPPASSQLVCVAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH20</accession>
    <name>A0A7U8TH20_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ArsR family transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="Activator_of_Hsp90_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="269" mass="29806" checksum="CF404E9EA97F0A8C" modified="2021-06-02" version="1">MPDMLEVAAEPTRRRLLQLLAPGERTVTQLASQFTVTRSAISQHLGMLAEAGLVTARKQGRERYYRLDERGVLRLRALMESFWSDELDRLVADAAHYPPSQGDCAMPFEKAVVVPLDPTSTFALITQPDRLRRWMAVAARIELRTGGAYRWTVTPGHSAAGTVIDVDPGKRVVFTWGWEDHGDPPPGGSTVTITLTPVDGGTEVRLVHDGLTAQQAARHAKGWNHFLDRLSSRQHGDAGPDEWAAAPDRSTKYLVPKQHWPFFSTYCAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THC3</accession>
    <name>A0A7U8THC3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03044</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898633.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THC3"/>
    <dbReference type="UniPathway" id="UPA00223"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="373" mass="40147" checksum="AABF5238CB79B54D" modified="2021-06-02" version="1">MTVVPENFVPGLDGVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQRVTFGDVWALLVDGNFGSGLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLLDIDDATARQQLARASVMALSYVAQSARGIYQPAVPQRIIDECSTVTARFMTRWQGEPDPRHIEAIDAYWVSAAEHGMNASTFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARVLPMLDEVERAGDARSVVKGILDRGEKLMGFGHRVYRAEDPRARVLRAAAERLGAPRYEVAVAVEQAALSELRERRPDRAIETNVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCAHILEQKRLGKLVRPSAIYVGPGPRSPESVDGWERVLTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THC7</accession>
    <name>A0A7U8THC7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="367" mass="40804" checksum="768DFA1944B64336" modified="2021-06-02" version="1">MTYTGSIRCEGDTWDLASSVGATATMVAAARAMATRAANPLINDQFAEPLVRAVGVDVLTRLASGELTASDIDDPERPNASMVRMAEHHAVRTKFFDEFFMDATRAGIRQVVILASGLDSRAYRLAWPAQTVVYEIDQPQVMGFKTRTLAELGATPTADRRVVTADLRADWPTALGAAGFDPTQPTAWSAEGLLRYLPPEAQDRLLDNVTALSVPDSRFATESIRNFKPHHEERMRERMTILANRWRAYGFDLDMNELVYFGDRNEPASYLSDNGWLLTEIKSQDLLTANGFQPFEDEEVPLPDFFYVSARLQRKHRQYPAHRKPAPSWRHTACPVNELSKSAAYTMTRSDAHQASTTAPPPPGLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THI7</accession>
    <name>A0A7U8THI7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02960</name>
        <name evidence="4" type="ORF">TBLG_03739</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404278.1">
        <property type="nucleotide sequence ID" value="NZ_KK338673.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THI7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010814">
        <property type="entry name" value="DUF1416"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07210">
        <property type="entry name" value="DUF1416"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0832">Ubl conjugation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="100" mass="10165" checksum="8CDBC094255BC876" modified="2021-06-02" version="1">MCSGPKQGLTLPASVDLEKETVITGRVVDGDGQAVGGAFVRLLDSSDEFTAEVVASATGDFRFFAAPGSWTLRALSAAGNGDAVVQPSGAGIHEVDVKIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THK2</accession>
    <name>A0A7U8THK2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THK2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035552">
        <property type="term" value="P:oxidative single-stranded DNA demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="PTHR31212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="105"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="205" mass="22648" checksum="4E871EAE209FC7CB" modified="2021-06-02" version="1">MCDKLGGVAIAVQGALFEHNERRQLGDGAFIDIRSGWLTGGEELLDALLSTVPWRAERRQMYDRVVDVPRLVSFHDLTIEDPPHPQLARMRRRLNDIYGGELGEPFTTAGLCYYRDGSDSVAWHGDTIGRGSTEDTMVAIVSLGATRVFALRPRGRGPSLRLPLAHGDLLVMGGSCQRTFEHAVPKTSAPTGPRVSIQFRPRDVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THN8</accession>
    <name>A0A7U8THN8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404614.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024244">
        <property type="entry name" value="DUF2537"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10801">
        <property type="entry name" value="DUF2537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="94" mass="9662" checksum="3B4953D9278B601E" modified="2021-06-02" version="1">MNDQRDQAVPWATGLAVAGFVAAVIAVAVVVLSLGLIRVHPLLAVGLNIVAVSGLAPTLWGWRRTPVLRWFVLGAAVGVAGAWLALLALTLGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THR9</accession>
    <name>A0A7U8THR9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001959">
        <property type="entry name" value="Transposase_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01385">
        <property type="entry name" value="OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OrfB_IS605" evidence="2">
        <location>
            <begin position="271"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="550" mass="59656" checksum="8ED9176D92CBFE3C" modified="2021-06-02" version="1">MIVRMRSCAQAAKVPEATGGVQLAGKPKPDGTPTFSRYVEIGVDFEAHRPVVESVSVLFELYDGDANSYAATGGPGAQLPSGWMVTAAKFEVEWPADPQRAGLVRSHFGARRKAFNWGLAQVKADLDAKAADPAHESVDWDLKSLRWAWNRAKDDVAPWWAENSKECYSSGLADLAQGLANWKAGKNGTRKGRRVGFPRFKSGRRDPGRVRFTTGTMRIEDDRRTITVPVIGPLRAKENTRRVQRHLVSGRAQILNMTLSQRWGRLFVAVCYALRTPTTRSPLTQPTVRAGMDLGVRTLATVATLDTATGEQTIIEYPNPAPLKATLVARRRAGRELSRRIPGSHGHRAVKAKLARLDRRCVHLRREAAHQLTTELAGTYGQVVIEDLDVAAMKRSMRRRAFRRSVSDAAMGLVAPQLAYKTAKCSGVLTVADRWFASSQIHHGCTSPDGTPCRLQGKGRIDKHLLCPVTGEVVDRDRNAALNLRDWPDNASRGPVGTTAPSAPGPTTTVGTGHGADTGSSGAGGASVRPRPRRAGRGEAKTQTPQGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI23</accession>
    <name>A0A7U8TI23_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oligopeptide-transport membrane protein ABC transporter oppB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406613.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI23"/>
    <dbReference type="GeneID" id="45425255"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="95"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="325" mass="35083" checksum="A3EA93995DEFE13A" modified="2021-06-02" version="1">MTRYLARRLLNYLVLLALASFLTYCLTSLAFSPLESLMQRSPRPPQAVIDAKAHDLGLDRPILARYANWVSHAVRGDFGTTITGQPVGTELGRRIGVSLRLLVVGSVFGTVAGVVIGAWGAIRQYRLSDRVMTTLALLVLSTPTFVVANLLILGALRVNWAVGIQLFDYTGETSPGVAGGVWDRLGDRLQHLILPSLTLALAAAAGFSRYQRNAMLDVLGQDFIRTARAKGLTRRRALLKHGLRTALIPMATLFAYGVAGLVTGAVFVEKIFGWHGMGEWMVRGISTQDTNIVAAITVFSGAVVLLAGLLSDVIYAALDPRVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIC2</accession>
    <name>A0A7U8TIC2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407404.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIC2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="10"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="141" mass="16027" checksum="85AC5CC04F2BD8F4" modified="2021-06-02" version="1">MQMSASNAFVEGFADFWKAPSPDRLTDHLHPDVVLVRPLSPPRHGLGAAQREFTRILGLLPDLHGEVDRWSQAGDVVFIEFRLIARLGSEVVEWPVVDRFLLRGDKAVERVSYFDSLPLLIKVVKHPSAWRGWLTTMRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIL2</accession>
    <name>A0A7U8TIL2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901145.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="152" mass="16825" checksum="2CEBA80E01C0060B" modified="2021-06-02" version="1">MVTSVADENVASRIASWGTGPAPDPRLDYAHAHLKGRRGRSPARPNAPIGARSFAVGRKICRVERFTLLEHGFVGHALHRVPCAGLVALVMSACSLAVCREVGNYAQRRVGRFAFFEQTFVRHALTPRCSRTDSKASYTQLNRICKFPPHWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIV1</accession>
    <name>A0A7U8TIV1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="79" mass="7435" checksum="919C31A270F76E33" modified="2021-06-02" version="1">MIGGKGGTGGNGGVGGTGGASALTIGNGSSAGAGGAGGAGGTGGTGGYIESLDGKAKPQRRNASTSPRVGQRRRHRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR45</accession>
    <name>A0A7U8TR45_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcriptional regulator, asnC-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415979.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR45"/>
    <dbReference type="GeneID" id="45427043"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HTH tetR-type" evidence="6">
        <location>
            <begin position="29"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="246" mass="27619" checksum="29437E47AD887B8E" modified="2021-06-02" version="1">MVRIPRPHPSAKPGVKVDARSERWREHRKKVRNEIVDAAFRAIDRLGPELSVRQIAEEAGTAKPKIYRHFTDKSDLLEAIGMRLRDMLWAAIFPSLDLATDSAREVIRRSVEEYVNLVDQHPNVLRVFIQGRSAKQSEATVRTLNEGREITLAMAEMFNNELREMELNRAALELAAFAAFGSAASATEWWLGPEPDSPRRMPREQFVAHLTTIMMGVIVGTAEALGIAVDPDQPIHDAVPNNPAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR46</accession>
    <name>A0A7U8TR46_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent alcohol dehydrogenase adhC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03665</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="8"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="346" mass="37105" checksum="792EDC0B970A2C6B" modified="2021-06-02" version="1">MSTVAAYAAMSATEPLTKTTITRRDPGPHDVAIDIKFAGICHSDIHTVKAEWGQPNYPVVPGHEIAGVVTAVGSEVTKYRQGDRVGVGCFVDSCRECNSCTRGIEQYCKPGANFTYNSIGKDGQPTQGGYSEAIVVDENYVLRIPDVLPLDVAAPLLCAGITLYSPLRHWNTGANTRVAIIGLGGLGHMGVKLGAAMGADVTVLSQSLKKMEDGLRLGAKSYYATADPDTFRKLRGGFDLILNTVSANLDLGQYLNLLDVDGTLVELGIPEHPMAVPAFALALMRRSLAGSNIGGIAETQEMLNFCAEHGVTPEIELIEPDYINDAYERVLASDVRYRFVIDISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR68</accession>
    <name>A0A7U8TR68_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="222" mass="24903" checksum="C0DFDDED6283ABE9" modified="2021-06-02" version="1">MTSRDGFTIVWDWNGTLCDDRTILLDAVGQTLVNEGFEPLSQQQLIQRFARPLRTFFENACGRDLLTSEWERVQSTFRRIYRSREAEVTLVEDAYDVLAQGNRSTAGQFLLSLAPHDELMHFVQKYGIAKWFNEIRGRTRPDQEKPMMLAELIMQRSLNPTRVVHIGDSLEDAAAASAVGAISVLVTGASLQPPDRVMLKQLQPFVASSLKQALQYAGGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR81</accession>
    <name>A0A7U8TR81_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR81"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="156" mass="17178" checksum="6182D072B906263E" modified="2021-06-02" version="1">MYSGCWINNQNGETRVGEDSLEDLEQRRARLYDQLAATGDFRRGSISENYRRCGKPNCVCAQEGHPGHGPRYLWTRTVAGRGTKGRQLSVEEVDKVRAELANYHRFAQVSEQIVAVNEAICEARPPNPAATAPPAGTTGHKKGGSATRSRRSSPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR84</accession>
    <name>A0A7U8TR84_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR84"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="104" mass="11767" checksum="0FB4D7C9E1AA9EDD" modified="2021-06-02" version="1">MVIRFDQIGSLVLSMKSLASLSFQRCLRENSSLVAALDRLDAAVDELSALSFDALTTPERDRARRDRDHHPWSRSRSQLSPRMAHGAVHQCQWPKAVWAVIDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRA3</accession>
    <name>A0A7U8TRA3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03712</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008526">
        <property type="entry name" value="YedI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30503">
        <property type="entry name" value="PTHR30503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05661">
        <property type="entry name" value="DUF808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016660">
        <property type="entry name" value="YedI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="306" mass="31839" checksum="7B4E004B7762B7CC" modified="2021-06-02" version="1">MSGGLFGLLDHVAVLARLAAASIDDIGAAAGRATAKAAGVVIDDTAVTPQYVHRITAERELPIIKRIAIGSVRNKLLLILPGALLLSQLVPWLLTPLLMLGATYLCYEGAEKVCGVIGGRGHDAAPQVAERELVAGAIRTDFILSAEIMVIALNEVADQPFVPRLVVLVIVALVITAAVYGVVAVIVQMDDVGLRLTQTASRFGQRIGGGLVAGMPKLLSALSAVGMGAMLWVGGHIVLVGSDHLGWHAPYRLVHHLDDHLVGSAGGALTWLVSTAACAATGLVIGIVVVALVHLVCFRPPRSRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRA4</accession>
    <name>A0A7U8TRA4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">NADH-quinone oxidoreductase subunit F</fullName>
            <ecNumber evidence="12">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03771</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="12"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416439.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRA4"/>
    <dbReference type="GeneID" id="45427137"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 12" id="KW-0288">FMN</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 12" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0874">Quinone</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="13">
        <location>
            <begin position="338"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD14873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="445" mass="48102" checksum="C02A660F43842926" modified="2021-06-02" version="1">MTTQATPLTPVISRHWDDPESWTLATYQRHDRYRGYQALQKALTMPPDDVISIVKDSGLRGRGGAGFATGTKWSFIPQGDTGAAAKPHYLVVNADESEPGTCKDIPLMLATPHVLIEGVIIAAYAIRAHHAFVYVRGEVVPVLRRLHNAVAEAYAAGFLGRNIGGSGFDLELVVHAGAGAYICGEETALLDSLEGRRGQPRLRPPFPAVAGLYGCPTVINNVETIASVPSIILGGIDWFRSMGSEKSPGFTLYSLSGHVTRPGQYEAPLGITLRELLDYAGGVRAGHRLKFWTPGGSSTPLLTDEHLDVPLDYEGVGAAGSMLGTKALEIFDETTCVVRAVRRWTEFYKHESCGKCTPCREGTFWLDKIYERLETGRGSHEDIDKLLDISDSILGKSFCALGDGAASPVMSSIKHFRDEYLAHVEGGGCPFDPRDSMLVANGVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRF8</accession>
    <name>A0A7U8TRF8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component system transcriptional regulator mtrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03884</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899985.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRF8"/>
    <dbReference type="GeneID" id="45427240"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="7"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="128"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="228" mass="25279" checksum="925DEBC495DFD5B6" modified="2021-06-02" version="1">MDTMRQRILVVDDDASLAEMLTIVLRGEGFDTAVIGDGTQALTAVRELRPDLVLLDLMLPGMNGIDVCRVLRADSGVPIVMLTAKTDTVDVVLGLESGADDYIMKPFKPKELVARVRARLRRNDDEPAEMLSIADVEIDVPAHKVTRNGEQISLTPLEFDLLVALARKPRQVFTRDVLLEQVWGYRHPADTRLVNVHVQRLRAKVEKDPENPTVVLTVRGVGYKAGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRH9</accession>
    <name>A0A7U8TRH9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03875</name>
        <name evidence="2" type="ORF">TBLG_03880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="237" mass="25004" checksum="941658EB55DAE7B0" modified="2021-06-02" version="1">MSGRRCAAAPIDSTAVTGDRDTWCVLDLVLPLECGGCGAPATRWCAACAAELSVAAGEPHVVSPRVDPQVPVFALGRYAGVRRQAILAMKEHGRRDLVAPLACALIVGVDHLLSWGMLENPLTMVPAPTRRWAARRRGGDPVSRMARIAGATLGRHHDVTVVPALRMRALARDSVGLGASARERNITGRVLLRGQRPRNEVVLVDDIITTGATARESVRVLQAAGVRVGAVLAVAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRL6</accession>
    <name>A0A7U8TRL6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="176" mass="19849" checksum="56D631D54AB2913E" modified="2021-06-02" version="1">MHPMIPAEYISNIIYEGPGADSLSAAAEQLRLMYNSANMTAKSLTDRLGELQENWKGSSSDLLADAAGRYLDWLTKHSRQILETAYVIDFLAYVYEETRHKVVPPATIANNREERRRLIASNVAGVNTPAIADLDAQYDQYRARNVAVMNAYVSWTRSALSDLPRWREPPQIYRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN6</accession>
    <name>A0A7U8TRN6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03966</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417295.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427325"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="124" mass="14031" checksum="3D5924F60485B171" modified="2021-06-02" version="1">MAHGNVSRCEESSLHDVCCGRLSALTDRELSERLTALPGWELVDGKLRHTFGFGSFDQSMKFVAKIAAIADKFNHHPDICVHNKRSVRLTCWTRQMHCLTRVDFDLAEAFSAVHDEQCSQQVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRP5</accession>
    <name>A0A7U8TRP5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418013.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRP5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="6">
        <location>
            <begin position="49"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="7">
        <location>
            <begin position="152"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="212" mass="22919" checksum="12A157F6F66BB0C3" modified="2021-06-02" version="1">MVDPGVSPGCVRFVTLEISPSMTMQGERLDAVVAEAVAGDRNALREVLETIRPIVVRYCRARVGTVERSGLSADDVAQEVCLATITALPRYRDRGRPFLAFLYGIAAHKVADAHRAAGRDRAYPAETLPERWSADAGPEQMAIEADSVTRMNELLEILPAKQREILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAAGDYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRS3</accession>
    <name>A0A7U8TRS3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417903.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRS3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="217" mass="23664" checksum="0AFCDC61F2BD0156" modified="2021-06-02" version="1">MSISAVVFDRDGVLTSFDWTRAEEDVRRITGLPLEEIERRWGGWLNGLTIDDAFVETQPISEFLSSLARELELGSKARDELVRLDYMAFAQGYPDARPALEEARRRGLKVGVLTNNSLLVSARSLLQCAALHDLVDVVLSSQMIGAAKPDPRAYQAIAEALGVSTTSCLFFDDIADWVEGARCAGMRAYLVDRSGQTRDGVVRDLSSLGAILDGAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRU5</accession>
    <name>A0A7U8TRU5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical proline rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417421.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031120831" evidence="2">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="3">
        <location>
            <begin position="36"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="281" mass="28652" checksum="67AC4F67C97C7DB6" modified="2021-06-02" version="1">MFTGIASHAGALGAALVVLIGAAILHDGPAAADPNQDDRFLALLEKKEIPAVANVPRVIDAAHKVCRKLDGGMPVNDIVDGLRNDAYNIDPVMRLYPVRLTTTMTRFISAAVEIYCPNHHSKMAFAMANFEPGSNEPTHRVAASTRSAVNSGSDLRASVSDMTIMSPGWREPTGAMLASVLGAVRAGDPLIPNPPPIPVPPPAAQTLIPPPPIVAPPPPRPAPPQQPPPPPPEVEPPAGVPQSGGAAGSGGAGSGGGGGGDGPVEPSPARPMPPGFIRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRV2</accession>
    <name>A0A7U8TRV2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="8">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">trpS</name>
        <name evidence="10" type="ORF">TBLG_04066</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="8"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417440.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRV2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_B">
        <property type="entry name" value="Trp_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024109">
        <property type="entry name" value="Trp-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>L-tryptophan</name>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD15172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="336" mass="36272" checksum="8B6512E39649AEB3" modified="2021-06-02" version="1">MSTPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQDPEALRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGCFTGFGQASRMTQFKDKSARQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHLELARDVAQRFNSRFPGTLVVPDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDDPALSAKKIRSAVTDSERDIRYDPDVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELTADPAELEAVLAAGAQRAHDVASKTVQRVYDRLGFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRV6</accession>
    <name>A0A7U8TRV6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_04071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417418.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRV6"/>
    <dbReference type="GeneID" id="45427334"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="7">
        <location>
            <begin position="48"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="302"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="383" mass="38805" checksum="59C633CAAE97FC58" modified="2021-06-02" version="1">MTVLGADAVVIDGRICRPGWVHTADGRILSGGAGAPPMPADAEFPDAIVVPGFVDMHVHGGGGASFADGNAADIARAAEFHLRHGTTTTLASLVTAGPAELLSAVGALAEATRDGVVAGIHLEGPWLSPARCGAHDHTRMRAPDPAEIESVLAAADGAVRMVTLAPELPGSDAAIRRFRDAEVVVAVGHTDATYTQTRHAIDLGATVGTHLFNAMPPLDHRAPGPVLALLCDPRVTVEIIADGVHVHPAVVHAVIEAVGPDRVAVVTDAIAAAGCGDGAFRLGTMPIEVESSVARVAGASTLAGSTTTMDQLFRTVAGLGSKSDSAGDVALAAAVQVTSATPARALGLTGVGRLAAGYAANLVVLDRDLRVTAVMVNDDWRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRY4</accession>
    <name>A0A7U8TRY4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, merR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_04068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900026.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRY4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015358">
        <property type="entry name" value="Tscrpt_reg_MerR_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00376">
        <property type="entry name" value="MerR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09278">
        <property type="entry name" value="MerR-DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH merR-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="146" mass="16169" checksum="4776B7E29CE16ED7" modified="2021-06-02" version="1">MKISEVAALTNTSTKTLRFYENSGLLPPPARTASGYRNYGPEIVDRLRFIHRGQAAGLALQEVRQILAIHDRGEAPCAHVRQLLSTRIDEVRAQIAELIALEGHLQTLLDHASYGPPTEHDHSTVCWILESDLDEPTAIEVSDIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRY5</accession>
    <name>A0A7U8TRY5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRY5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019922">
        <property type="entry name" value="Lucif-like_OxRdatse_MSMEG_4141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03620">
        <property type="entry name" value="F420_MSMEG_4141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="285" mass="30651" checksum="481AFC8647F1F3AB" modified="2021-06-02" version="1">MTNCAAGKPSSGPNLGRFGSFGRGVTPQQATEIEALGYGAVWVGGSPPAALSWVEPILQATTTLCVATGIVNIWSAPAQRVAESFHRIEAAYPGRFLLGIGVGHAEMISEYRKPYNALVEYLDRLDDYGVPANRRVVAALGPRVLGLSARRSAGAHPYLTTPEHTARARELIGPSAFLAPEHKVVLTTDSARARTVGRQALDMYFNLANYRNNWKRLGFTDDEVSRPGSDRLVDAVVAYGTPDAIAARLNEHLLAGADHVPIQVLTEDDNLVSALTELAKPLRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRZ8</accession>
    <name>A0A7U8TRZ8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dicarboxylic acid transport membrane protein kGTP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_04126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="22"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="449" mass="49551" checksum="CDE48504549C4CBF" modified="2021-06-02" version="1">MTVSIAPPSRPSQAETRRAIWNTIRGSSGNLVEWYDVYVYTVFATYFEDQFFDRADRNSTVYVYAIFAVTFVTRPVGSWFFGRFADRRGRRAALTFSVSLMAACSLIVALVPSRSSIGVAAPILLILCRLVQGFATGGEYGTSATYMSEAATRERRGYFSSFQYVTLVGGHVLAQFTLLVILAVFTREQVHEFGWRIGFAVGGGAAIVVFWLRRTMDESLSQERLTAIKAGRDHDSGSLRELATHYWKPLLLCFLVTLGGTVAFYTYSVNAPAIVKSVYGSQAMTATWINLVGLILLMMLQPIGGMISDKIGRKPLLLWFGVGGLIYTYVLVTYLPETRSPTMSFLLVAVGYVILTGYCSINALVKSELFPAHVRALGVGVGYALANSVFGGTAPLIYQALKERDQVPMFIAYVTACIAVSLIVYVFFIKNKADTYLDREQGFAFYGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSN7</accession>
    <name>A0A7U8TSN7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03669</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899895.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TSN7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="524" mass="58777" checksum="BABAF86F4DD1AB54" modified="2021-06-02" version="1">MSIADTAAKPSTPSPANQPPVRTRAVIIGTGFSGLGMAIALQKQGVDFVILEKADDVGGTWRDNTYPGCACDIPSHLYSFSFEPKADWKHLFSYWDEILGYLKGVTDKYGLRRYIEFNSLVDRGYWDDDECRWHVFTADGREYVAQFLISGAGALHIPSFPEIAGRDEFAGPAFHSAQWDHSIDLTGKRVAIVGTGASAIQIVPEIVGQVAELQLYQRTPPWVVPRTNEELPVSLRRALRTVPGLRALLRLGIYWAQEALAYGMTKRPNTLKIIEAYAKYNIRRSVKDRELRRKLTPRYRIGCKRILNSSTYYPAVADPKTELITDRIDRITHDGIVTADGTGREVFREADVIVYATGFHVTDSYTYVQIKGRHGEDLVDRWNREGIGAHRGITVANMPNLFFLLGPNTGLGHNSVVFMIESQIHYVADAIAKCDRMGVQALAPTREAQDRFNQELQRRLAGSVWNSGGCRSWYLDEHGKNTVLWCGYTWQYWLTTRSVNPAEYRFFGIGNGLSSDRATVAAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT73</accession>
    <name>A0A7U8TT73_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13502"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417156.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT73"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="11"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="130"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="524"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD15026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="600" mass="63783" checksum="1B7507AB78E217F0" modified="2021-06-02" version="1">MASHAGSRIARISKVLVANRGEIAVRVIRAARDAGLPSVAVYAEPDAESPHVRLADEAFALGGQTSAESYLDFAKILDAAAKSGANAIHPGYGFLAENADFAQAVIDAGLIWIGPSPQSIRDLGDKVTARHIAARAQAPLVPGTPDPVKGADEVVAFAEEYGLPIAIKAAHGGGGKGMKVARTIDEIPELYESAVREATAAFGRGECYVERYLDKPRHVEAQVIADQHGNVVVAGTRDCSLQRRYQKLVEEAPAPFLTDFQRKEIHDSAKRICKEAHYHGAGTVEYLVGQDGLISFLEVNTRLQVEHPVTEETAGIDLVLQQFRIANGEKLDITEDPTPRGHAIEFRINGEDAGRNFLPAPGPVTKFHPPSGPGVRVDSGVETGSVIGGQFDSMLAKLIVHGADRAEALARARRALNEFGVEGLATVIPFHRAVVSDPAFIGDANGFSVHTRWIETEWNNTIEPFTDGEPLDEDARPRQKVVVEIDGRRVEVSLPADLALSNGGGCDPVGVIRRKPKPRKRGAHTGAAASGDAVTAPMQGTVVKFAVEEGQEVVAGDLVVVLEAMKMENPVTAHKDGTITGLAVEAGAAITQGTVLAEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT84</accession>
    <name>A0A7U8TT84_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03765</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT84"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="3">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="344"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="409" mass="39069" checksum="59194B4AE37841AD" modified="2021-06-02" version="1">MSFVVLPPEINSLRMFIGAGTAPMLAAAAAWDGLAEELGTAAQSFASVTAGLAGQAWQGPAALAMAAAAAPYAGWLTAAAAQSAGAAGQARAVASIFEAAQAATVLPAAVAANRDAFVQLVMTNLFGQNAPLIAAAEGVYEEMWAADVAAMSGYYSGASAIAAQVVPWASLLQRFPGLGAGATGATGGESVGTGATGGESVGTGGGESVGTGGATASGGGVGYVGGGVASAGLAAGDPAHGSVGQGNFGGGDVGAGDVVASSATSAHAGVVSPGFIGAPLALAALGQMARGGTNSAPGTATESARAPEPAASAPPEAVVEVPELEVPAMGVLPTVDPKVAAKAAPLSTTRVGQSAGSGIPESTLRTAQGQQASETSAAEETAPSLRPEAAAGQLRPRVRQDPKIQMRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTE0</accession>
    <name>A0A7U8TTE0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03855</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416897.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTE0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014293">
        <property type="entry name" value="RNA_pol_sigma70_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02947">
        <property type="entry name" value="SigH_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="37"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="140"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD14957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="216" mass="24225" checksum="AC0C33B47DB40CFD" modified="2021-06-02" version="1">MADIDGVTGSAGLQPGPSEETDEELTARFERDAIPLLDQLYGGALRMTRNPADAEDLLQETMVKAYAGFRSFRHGTNLKAWLYRILTNTYINSYRKKQRQPAEYPTEQITDWQLASNAEHSSTGLRSAEVEALEALPDTEIKEALQALPEEFRMAVYYADVEGFPYKEIAEIMDTPIGTVMSRLHRGRRQLRGLLADVARDRGFARGEQAHEGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTI2</accession>
    <name>A0A7U8TTI2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative pterin-4-alpha-carbinolamine dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03731</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416149.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTI2"/>
    <dbReference type="GeneID" id="45427109"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTHR12599"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="SSF55248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="131" mass="14558" checksum="84453C25A695F514" modified="2021-06-02" version="1">MTVSTPEQHEQRASHDASEGKHNVCQGRLAALADAAVSEKLGALPGWQLLDMRLSRAFQCTNFDQSIDFMNRVASIANDINHHPDIAVLDKRSVRVTAWTRKLGYLTDIDFDLAASVEAMYATEFADRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTI7</accession>
    <name>A0A7U8TTI7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_04085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTI7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="281" mass="30484" checksum="F3F68F862A190F44" modified="2021-06-02" version="1">MFAELIRAGLQALIEAEATEAIGAGRYERSDGRIVHRNGHRPKTVSTTAGDIEVQIPKLRAGSFFPSLLERRRRIDKALHAVIMEAYVHGVSTRSVDDLVAAMGVQAGVSKSEVSRICAGLDTEIEAFRTRSLTHTEFPYVFCDATFCKVRVGAHVVSQALVVATGVSIDGTREVLGTAVGDSESYEFWREFLASLKARGLTGVHLVISDAHAGLKAAVAQQFSGASWQRCRVHFMRNLYTAVAAKHAPAVTVAVKTIFAHTDPEEVGAQWDRVADPLCQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTQ5</accession>
    <name>A0A7U8TTQ5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ZnMc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022603">
        <property type="entry name" value="DUF3152"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11350">
        <property type="entry name" value="DUF3152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="ZnMc" evidence="2">
        <location>
            <begin position="83"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="285" mass="31066" checksum="A9E1F9F9FA6F32A8" modified="2021-06-02" version="1">MSTYGWRAYALPVLMVLTTVVVYQTVTGTSTPRPAAAQTVRDSPAIGVVGTAILDAPPRGLAVFDANLPAGTLPDGGPFTEAGDKTWRVVPGTTPQVGQGTVKVFRYTVEIENGLDPTMYGGDNAFAQMVDQTLTNPKGWTHNPQFAFVRIDSGKPDFRISLVSPTTVRGGCGYEFRLETSCYNPSFGGMDRQSRVFINEARWVRGAVPFEGDVGSYRQYVINHEVGHAIGYLRHEPCDQQGGLAPVMMQQTFSTSNDDAAKFDPDFVKADGKTCRFNPWPYPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTR3</accession>
    <name>A0A7U8TTR3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA (cytidine/uridine-2'-O-)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04035</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could methylate the ribose at the nucleotide 34 wobble position in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="1"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417878.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTR3"/>
    <dbReference type="GeneID" id="45427365"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1 2">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="154" mass="16517" checksum="413E209E8EA477EE" modified="2021-06-02" version="1">MFRLLFVSPRIAPNTGNAIRTCAATGCELHLVEPLGFDLSEPKLRRAGLDYHDLASVTVHASLAHAWEALSPARVFAFTAQATTLFTNVGYRAGDVLMFGPEPTGLDEATLADTHITGQVRIPMLAGRRSLNLSNAAAVAVYEAWRQHGFAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTR7</accession>
    <name>A0A7U8TTR7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416886.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTR7"/>
    <dbReference type="GeneID" id="45427213"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038424">
        <property type="entry name" value="H_kinase_PdtaS_GAF_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022066">
        <property type="entry name" value="PdtaS_GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011495">
        <property type="entry name" value="Sig_transdc_His_kin_sub2_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12282">
        <property type="entry name" value="H_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07568">
        <property type="entry name" value="HisKA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="300"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="501" mass="54012" checksum="DF099B268388AD00" modified="2021-06-02" version="1">MSTLGDLLAEHTVLPGSAVDHLHAVVGEWQLLADLSFADYLMWVRRDDGVLVCVAQCRPNTGPTVVHTDAVGTVVAANSMPLVAATFSGGVPGREGAVGQQNSCQHDGHSVEVSPVRFGDQVVAVLTRHQPELAARRRSGHLETAYRLCATDLLRMLAEGTFPDAGDVAMSRSSPRAGDGFIRLDVDGVVSYASPNALSAYHRMGLTTELEGVNLIDATRPLISDPFEAHEVDEHVQDLLAGDGKGMRMEVDAGGATVLLRTLPLVVAGRNVGAAILIRDVTEVKRRDRALISKDATIREIHHRVKNNLQTVAALLRLQARRTSNAEGREALIESVRRVSSIALVHDALSMSVDEQVNLDEVIDRILPIMNDVASVDRPIRINRVGDLGVLDSDRATALIMVITELVQNAIEHAFDPAAAEGSVTIRAERSARWLDVVVHDDGLGLPQGFSLEKSDSLGLQIVRTLVSAELDGSLGMRDARERGTDVVLRVPVGRRGRLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TUC6</accession>
    <name>A0A7U8TUC6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MCE-family protein mce4C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418967.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427483"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="44"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="357" mass="38150" checksum="47C19DD8EAB80BCA" modified="2021-06-02" version="1">MLNRKPSSKHERDPLRTGIFGLVLVICVVLIAFGYSGLPFWPQGKTYDAYFTDAGGITPGNSVYVSGLKVGAVSAVSLAGNSAKVTFSVDRSIVVGDQSLAAIRTDTILGERSIAVSPAGSGKSTTIPLSRTTTPYTLNGVLQDLGRNANDLNRPQFEQALNVFTQALHDATPQVRGAVDGLTSLSRALNRRDEALQGLLAHAKSVTSVLSERAEQVNKLVEDGNQLFAALDARRAALSALISGIDDVAAQISGFVADNRKEFGPALSKLNLVLANLNERRDYITEALKRLPTYATTLGEVVGSGPGFNVNVYSVLPGPLVATVFDLVFQPGKLPDSLADYLRGFIQERWIIRPKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y235</accession>
    <name>A0A7U8Y235_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="36" mass="3965" checksum="760A928E6B9EF424" modified="2021-06-02" version="1" fragment="single">KASCSCWMPRLSSRSPPCTCHSVCRWASTATGRRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2B0</accession>
    <name>A0A7U8Y2B0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, marR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404606.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2B0"/>
    <dbReference type="GeneID" id="45424844"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="143" mass="15576" checksum="F9E2D59CD77E0CE8" modified="2021-06-02" version="1">MLDSDARLASDLSLAVMRLSRQLRFRNPSSPVSLSQLSALTTLANEGAMTPGALAIRERVRPPSMTRVIASLADMGFVDRAPHPIDGRQVLVSVSESGAELVKAARRARQEWLAERLATLNRSERDILRSAADLMLALVDESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2E7</accession>
    <name>A0A7U8Y2E7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="SSF50630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="270" mass="27220" checksum="908DC9D4837CA386" modified="2021-06-02" version="1">MTNATVPLQLVNTTEPVVFISLNGGQMVPVLLDTGSTGLVMDSQFLTQNFGPVIGTGTAGYAGGLTYNYNTYSTTVDFGNGLLTLPTSVNVVTSSSPGTLGNFLSRSGAVGVLGIGPNNGFPGTSSIVTAMPGLLNNGVLIDESAGILQFGPNTLTGGITISGAPISTVAVQIDNGPLQQAPVMFDSGGINGTIPSALASLPSGGFVPAGTTISVYTSDGQTLLYSYTTTATNTPFVTSGGVMNTGHVPFAQQPIYVSYSPTAIGTTTFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2I2</accession>
    <name>A0A7U8Y2I2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2I2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="61" mass="6588" checksum="1B6B7109E694AD7A" modified="2021-06-02" version="1">MKELSVAEQRYQAVLAVISDGLSISQVAEKVGVSRQTLHTWLARYEAEGLDGLRIGTGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2J4</accession>
    <name>A0A7U8Y2J4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018763">
        <property type="entry name" value="DUF2334"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10096">
        <property type="entry name" value="DUF2334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="228" mass="25052" checksum="FC972C575D55BF7E" modified="2021-06-02" version="1">MSVSGIGESTLADVDAFCAEMDARSVPVSLLVAPRMRDDYRLDRDPRTVDWLTGRRAAGDALVLHGYDEAATKRRRGEFAMLRAHEANLRLMAADRVLEHLGLRTRLFAAPGWLVSPGVRTALPANGFRLLADLHGITDLVRLTTVRARVLGIGEGFLAEPWWCRMVVMSAERIARRGGVVRIAVAARHLRKSGPLQAMLDAVDLAMLQGCTPMVYRWRADAAVLDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2N9</accession>
    <name>A0A7U8Y2N9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplN</name>
        <name evidence="6" type="ORF">TBLG_02858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403649.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2N9"/>
    <dbReference type="GeneID" id="64238840"/>
    <dbReference type="GeneID" id="66747017"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="122" mass="13428" checksum="654100DA6F054A0D" modified="2021-06-02" version="1">MIQQESRLKVADNTGAKEILCIRVLGGSSRRYAGIGDVIVATVKDAIPGGNVKRGDVVKAVVVRTVKERRRPDGSYIKFDENAAVIIKPDNDPRGTRIFGPVGRELREKRFMKIISLAPEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2V1</accession>
    <name>A0A7U8Y2V1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein lpqU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2V1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043426">
        <property type="entry name" value="MltB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30163">
        <property type="entry name" value="PTHR30163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="243" mass="25828" checksum="0AA42F2C201E2868" modified="2021-06-02" version="1">MSPRRWLRAVAVIGATAMLLASSCTWQLSLFIPDGVPPPPGDPVPPVDTHAGGRPADQLREWAEKRAAALGIPVIALEAYAYAARVAEVENPKCHLAWTTLAGIGRVESHHGTYRGATIAPNGDVSPPIRGVRLDGTGGTLRIVDRDGGGLDGDAAVERAMGPMQFISETWRLYGVAARNDGIANVDNIDDAALSAAGYLCWRGKDLATPRGWITALRAYNNSVIYARAVRDWATAYAAGHPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2W1</accession>
    <name>A0A7U8Y2W1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035166">
        <property type="entry name" value="DUF5336"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17270">
        <property type="entry name" value="DUF5336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="303" mass="30234" checksum="FBFD8BDB621E04B4" modified="2021-06-02" version="1">MTYSPGNPGYPQAQPAGSYGGVTPSFAHADEGASKLPMYLNIAVAVLGLAAYFASFGPMFTLSTELGGGDGAVSGDTGLPVGVALLAALLAGVALVPKAKSHVTVVAVLGVLGVFLMVSATFNKPSAYSTGWALWVVLAFIVFQAVAAVLALLVETGAITAPAPRPKFDPYGQYGRYGQYGQYGVQPGGYYGQQGAQQAAGLQSPSPQQSPQPPGYGSQYGGYSSSPSQSGSGYTAQPPAQPPAQSGSQQSHQGPSTPPTGFPSFSPPPPVSAGTGSQAGSAPVNYSNPSGGEQSSSPGGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Y3</accession>
    <name>A0A7U8Y2Y3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Resuscitation-promoting factor rpfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase family. Rpf subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Y3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040010">
        <property type="term" value="P:positive regulation of growth rate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13925">
        <property type="entry name" value="RPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007137">
        <property type="entry name" value="DUF348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011098">
        <property type="entry name" value="G5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010618">
        <property type="entry name" value="RPF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03990">
        <property type="entry name" value="DUF348"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07501">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06737">
        <property type="entry name" value="Transglycosylas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01208">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51109">
        <property type="entry name" value="G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030506750" evidence="3">
        <location>
            <begin position="23"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="G5" evidence="4">
        <location>
            <begin position="192"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="362" mass="38077" checksum="0495538C70373310" modified="2021-06-02" version="1">MLRLVVGALLLVLAFAGGYAVAACKTVTLTVDGTAMRVTTMKSRVIDIVEENGFSVDDRDDLYPAAGVQVHDADTIVLRRSRPLQISLDGHDAKQVWTTASTVDEALAQLAMTDTAPAAASRASRVPLSGMALPVVSAKTVQLNDGGLVRTVHLPAPNVAGLLSAAGVPLLQSDHVVPAATAPIVEGMQIQVTRNRIKKVTERLPLPPNARRVEDPEMNMSREVVEDPGVPGTQDVTFAVAKVNGVETGRLPVANVVVTPAHEAVVRVGTKPGTEVPPVIDGSIWDAIAGCEAGGNWAINTGNGYYGGVQFDQGTWEANGGLRYAPRADLATREEQIAVAEVTRLRQGWGAWPVCAARAGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y304</accession>
    <name>A0A7U8Y304_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cellulase celA2b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="PTHR34002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="150" mass="16347" checksum="5F71AB75F0FEE894" modified="2021-06-02" version="1">MGTNLPTEVGQILSAPTSIDYNYPTTGVWDASYDICLDSTPKTTGVNQQEIMIWFNHQGSIQPVGSPVGNTTIEGKNFVVWDGSNGMNNAMAYVATEPIEVWSFDVMSFVDHTATMEPITDSWYLTSIRAGLSPERRCGSGGRFVSAKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y3B0</accession>
    <name>A0A7U8Y3B0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrABC system protein C</fullName>
            <shortName evidence="6">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uvrC</name>
        <name evidence="10" type="ORF">TBLG_03608</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407347.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y3B0"/>
    <dbReference type="GeneID" id="45425398"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 6" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="GIY-YIG" evidence="8">
        <location>
            <begin position="16"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="7">
        <location>
            <begin position="208"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="UVRC" evidence="9">
        <location>
            <begin position="259"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD13024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="646" mass="71614" checksum="CD7792F6C54E6709" modified="2021-06-02" version="1">MPDPATYRPAPGSIPVEPGVYRFRDQHGRVIYVGKAKSLRSRLTSYFADVASLAPRTRQLVTTAAKVEWTVVGTEVEALQLEYTWIKEFDPRFNVRYRDDKSYPVLAVTLGEEFPRLMVYRGPRRKGVRYFGPYSHAWAIRETLDLLTRVFPARTCSAGVFKRHRQIDRPCLLGYIDKCSAPCIGRVDAAQHRQIVADFCDFLSGKTDRFARALEQQMNAAAEQLDFERAARLRDDLSALKRAMEKQAVVLGDGTDADVVAFADDELEAAVQVFHVRGGRVRGQRGWIVEKPGEPGDSGIQLVEQFLTQFYGDQAALDDAADESANPVPREVLVPCLPSNAEELASWLSGLRGSRVVLRVPRRGDKRALAETVHRNAEDALQQHKLKRASDFNARSAALQSIQDSLGLADAPLRIECVDVSHVQGTDVVGSLVVFEDGLPRKSDYRHFGIREAAGQGRSDDVACIAEVTRRRFLRHLRDQSDPDLLSPERKSRRFAYPPNLYVVDGGAPQVNAASAVIDELGVTDVAVIGLAKRLEEVWVPSEPDPIIMPRNSEGLYLLQRVRDEAHRFAITYHRSKRSTRMTASALDSVPGLGEHRRKALVTHFGSIARLKEATVDEITAVPGIGVATATAVHDALRPDSSGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y418</accession>
    <name>A0A7U8Y418_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="340" mass="30078" checksum="5D9707BA1A9B0F15" modified="2021-06-02" version="1">MIPVSGGCRAARGGSGSHPPVPTAHPATPPPSGGQRRATAAKACPVWAGSATPAWMAAPAETVGPVDPGGAWAGNGGTGGAGGTGGVGGAGGTGGVGGTGGSGSDGVNGSSAGADGHPGGTGGVGGTGGKGGDGGDGGAAPNGVAGSQGPGGAGGDGGTGGVGGNGGRGIDGADGATAGARGQDGGAGGAGGKGGRGGTGGPGGAGPAGTTGSQGAGGYGGSGGTGGDLGDGGNGANGSVFPNNGNGGNGGNGGNAGPSGAGGIVGSGSTFRCDRLRQQLFTFICGNAGYGRQRRPCPQRQRRRPCGNGRQRSVSAACAVAVGPAATSPTVVLCQLGHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y493</accession>
    <name>A0A7U8Y493_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein TBLG_02694</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402987.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y493"/>
    <dbReference type="GeneID" id="45424530"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="163" mass="18078" checksum="13C83B3033609E16" modified="2021-06-02" version="1">MADSSFDIVSKVDRQEVDNALNQAAKELATRFDFRGTDTKIAWKGDEAVELTSSTEERVKAAVDVFKEKLIRRDISLKAFEAGEPQASGKTYKVTGALKQGISSENAKKITKLIRDAGPKNVKTQIQGDEVRVTSKKRDDLQAVIAMLKKADLDVALQFVNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4B9</accession>
    <name>A0A7U8Y4B9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03022</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031308">
        <property type="entry name" value="UCP028777"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005185">
        <property type="entry name" value="YccF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03733">
        <property type="entry name" value="YccF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028777">
        <property type="entry name" value="UCP028777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="YccF" evidence="2">
        <location>
            <begin position="69"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="130" mass="13759" checksum="8D7C8AFA8F4F0F02" modified="2021-06-02" version="1">MRLILNVIWLVFGGLWLALGYLLASLVCFLLIITIPFGFAALRIAASYALWPFGRTIVEKPTAGTGALIGNVIWVLLFGIWLALGHLVSAAAMAVTIIGIPLALANLKLIPVSLVPLGKDIVGVNSQVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4D1</accession>
    <name>A0A7U8Y4D1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="535" mass="56174" checksum="6C4AA92094DCE34D" modified="2021-06-02" version="1">MSDHDRDFDVVVVGGGHNGLVAAACLARAGLRVRLLERLAQTGGAAVSIQAFDGVEVALSRYSYLVSLLPSRIVADLGAPVRLARRPFSSYTPAPATAGRSGLLIGPTGEPRAAHLAAIGAAPDAHGFAAFYRRCRLVTARLWPTLIEPLRTREQARRDIVEYGGHEAAAAWQAMVDEPIGHAIAGAVANDLLRGVIATDALIGTFARMHEPSLMQNICFLYHLVGGGTGVWHVPIGGMGSVTSALATAAARHGAEIVTGADVFALDPDGTVRYHSDGSDGAEHLVRGRFVLVGVTPAVLASLLGEPVAALAPGAQVKVNMVVRRLPRLRDDSVTPQQAFAGTFHVNETWSQLDAAYSQAASGRLPDPLPCEAYCHSLTDPSILSARLRDAGAQTLTVFGLHTPHSVFGDTEGLAERLTAAVLASLNSVLAEPIQDVLWTDAQSKPCIETTTTLDLQRTLGMTGGNIFHGALSWPFADNDDPLDTPARQWGVATDHERIMLCGSGARRGGAVSGIGGHNAAMAVLACLASRRKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4I5</accession>
    <name>A0A7U8Y4I5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_17 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4I5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014942">
        <property type="entry name" value="AbiEii"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08843">
        <property type="entry name" value="AbiEii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_17" evidence="1">
        <location>
            <begin position="195"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="251" mass="28285" checksum="08C216032034BCD7" modified="2021-06-02" version="1">MRADVTAEHLTQVVRDIAVIDIDDGVAFNLDTSSVQEIRERADYPGLRVRVAMSVGPWQGIAAWDVSTGEPIAPWPTRVTIDRILGEPITLLGYAPETIIAEKGVTILERGITSTRWRDYVDIVQLDRRGIDDDELLRSARAVAQYRGATLEPVAPHLAGYGAVAQAKWATEHGRCQHCWRHWKPAHVGRRNMDLLDAKQVSEMIGVPVGTLRHWRHSDIGPASFTLGRRVVYRRDEVSRWISKRESATRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4M3</accession>
    <name>A0A7U8Y4M3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03337</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898748.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4M3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1232" mass="136956" checksum="F12194DA383644F9" modified="2021-06-02" version="1">MTVTPHVGGPLEELLERSGRFFTPGEFSADLRTVTRRGGREGDVFYRDRWSHDKVVRSTHGVNCTGSCSWKIYVKDGIITWETQQTDYPSVGPDRPEYEPRGCPRGASFSWYSYSPTRVRYPYARGVLVEMYREAKTRLGDPVLAWADIQADPERRRRYQQARGKGGLVRVSWAEASEMVAAAHVHTIKTYGPDRVAGFSPIPAMSMVSHAAGSRFVELIGGVMTSFYDWYADLPVASPQVFGDQTDVPESGDWWDASYLVMWGSNVPITRTPDAHWMAEARYRGAKVVVVSPDYADNTKFADEWVRCAAGTDTALAMAMGHVILSECYVRNQVPFFVDYVRRYTDLPFLIKLEKRGDLLVPGKFLTAADIGEESENAAFKPALLDELTNTVVVPQGSLGFRFGEDGVGKWNLDLGSVVPALSVEMDKAVNGDRSAELVTLPSFDTIDGHGETVSRGVPVRRAGKHLVCTVFDLMLAHYGVARAGLPGEWPTGYHDRTQQNTPAWQESITGVPAAQAIRFAKEFARNATESGGRSMIIMGGGICHWFHSDVMYRSVLALLMLTGSMGRNGGGWAHYVGQEKVRPLTGWQTMAMATDWSRPPRQVPGASYWYAHTDQWRYDGYGADKLASPVGRGRFAGKHTMDLLTSATAMGWSPFYPQFDRSSLDVADEARAAGRDVGDYVAEQLAQHKLKLSITDPDNPVNWPRVLTVWRANLIGSSGKGGEYFLRHLLGTDSNVQSDPPTDGVHPRDVVWDSDIPEGKLDLIMSIDFRMTSTTLVSDVVLPAATWYEKSDLSSTDMHPYVHSFSPAIDPPWETRSDFDAFAAIARAFSALAKRHLGTRTDVVLTALQHDTPDEMAYPDGTERDWLATGEVPVPGRTMSKLTVVERDYTAIYDKWLTLGPLIDQFGMTTKGYTVHPFREVSELAANFGVMNSGVAVGRPAITTAKRMADVILALSGTCNGRLAVEGFLELEKRTGQRLAHLAEGSEERRITYADTQARPVPVITSPEWSGSESGGRRYAPFTINIEHLKPFHTLTGRMHFYLAHDWVEELGEQLPVYRPPLDMARLFNQPELGPTDDGLGLTVRYLTPHSKWSFHSTYQDNLYMLSLSRGGPTMWMSPGDAAKINVRDNDWVEAVNANGIYVCRAIVSHRMPEGVVFVYHVQERTVDTPRTETNGKRGGNHNALTRVRIKPSHLAGGYGQHAFAFNYLGPTGNQRDEVTVVRRRSQEVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4Q9</accession>
    <name>A0A7U8Y4Q9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase amiB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="332" mass="34791" checksum="6E54D298D58E4FA5" modified="2021-06-02" version="1">MDPTDLAFAGAAAQARMLADGALTAPMLLEVYLQRIERLDSHLRAYRVVQFDRARAEAEAAQQRLDAGERLPLLGVPIAIKDDVDIAGEVTTYGSAGHGPAATSDAEVVRRLRAAGAVIIGKTNVPELMIMPFTESLAFGATRNPWCLNRTPGGSSGGSAAAVAAGLAPVALGSDGGGSIRIPCTWCGLFGLKPQRDRISLEPHDGAWQGLSVNGPIARSVMDAALLLDATTTVPGPEGEFVAAAARQPGRLRIALSTRVPTPLPVRCGKQELAAVHQAGSPFVIWATTSSSAIPTIRLRPMPTTCPAFSAVSATTRTRRRTRTASKHVPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4R2</accession>
    <name>A0A7U8Y4R2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4R2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="158" mass="16462" checksum="ED9E6CCBF6C5A412" modified="2021-06-02" version="1">MRHAKSAYPDGIADHDRPLAPRGIREAGLAGGWLRANLPAVDAVLCSTATRARQTLAHTGIDAPARYAERLYGAAPGTVIEEINRVGDNVTTLLVVGHEPTTSALAIVLASISGTDAAVAERISEKFPTSGIAVLRVAGHWADVEPGCAALVGFHVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4R4</accession>
    <name>A0A7U8Y4R4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405345.1">
        <property type="nucleotide sequence ID" value="NZ_KK338665.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4R4"/>
    <dbReference type="GeneID" id="45425009"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="98" mass="10993" checksum="0ED04CBA64A779D1" modified="2021-06-02" version="1">MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGWSGMAEATSLDTMTQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4T3</accession>
    <name>A0A7U8Y4T3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018561">
        <property type="entry name" value="DUF2017"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09438">
        <property type="entry name" value="DUF2017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2017" evidence="1">
        <location>
            <begin position="32"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="218" mass="24054" checksum="3DB14E266FC84E8D" modified="2021-06-02" version="1">MPPVCGRRCSRTGEIRGYSGSIVRRWKRVETRDGPRFRSSLAPHEAALLKNLAGAMIGLLDDRDSSSPSDELEEITGIKTGHAQRPGDPTLRRLLPDFYRPDDLDDDDPTAVDGSESFNAALRSLHEPEIIDAKRVAAQQLLDTVPDNGGRLELTESDANAWIAAVNDLRLALGVMLEIGPRGPERLPGNHPLAAHFNVYQWLTVLQEYLVLVLMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4W5</accession>
    <name>A0A7U8Y4W5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_trans_2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406242.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4W5"/>
    <dbReference type="GeneID" id="45425178"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="324" mass="34379" checksum="7CE4AE274C1A23BA" modified="2021-06-02" version="1">MTASELVAGDLAGGRAPGALPLDTTWHRPGWTIGELEAAKAGRTISVVLPALNEEATIESVIDSISPLVDGLVDELIVLDSGSTDDTEIRAIASGARVVSREQALPEVPVRPGKGEALWRSLAATSGDIVVFIDSDLINPHPLFVPWLVGPLLTGEGIQLVKSFYRRPLQVSDVTSGVCATGGGRVTELVARPLLAALRPELGCVLQPLSGEYAASRELLTSLPFAPGYGVEIGLLIDTFDRLGLDAIAQVNLGVRAHRNRPLDELGAMSRQVIATLLSRCGIPDSGVGLTQFLPGGPDDSDYTRHTWPVSLVDRPPMKVMRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4Y6</accession>
    <name>A0A7U8Y4Y6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041685">
        <property type="entry name" value="AAA_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13175">
        <property type="entry name" value="AAA_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_15" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="875" mass="93351" checksum="366C580A3AAC97A2" modified="2021-06-02" version="1">MKLHRLALTNYRGIAHRDVEFPDHGVVVVCGANEIGKSSMVEALDLLLEYKDRSTKKEVKQVKPTNADVGSEVIAEISSGPYRFVYRKRFHKRCETELTVLAPRREQLTGDEAHERVRTMLAETVDTELWHAQRVLQAASTAAVDLSGCDALSRALDLAAGDDAALSGTESLLIERIEAEYARYFTPTGRPTGEWSAAVSRLAAAEAAVADCAAAVAEVDDGVRRHTELTEQVAELSQQLLAHQLRLEAARVAAEKIAAITDDAREAKLIATAAAATSGASTAAHAGRLGLLTEIDTRTAAVVAAEAKARQAADEQATARAEAEACDAALTEATQVLTAVRLRAESARRTLDQLADCEEADRLAARLARIDDIEGDRDRVCAELSAVTLTEELLSRIERAAAAVDRGGAQLASISAAVEFTAAVDIELGVGDQRVSLSAGQSWSVTATGPTEVKVPGVLTARIVPGATALDFQAKYAAAQQELADALAAGEVADLAAARSADLCRRELLSRRDQLTATLAGLCGDEQVDQLRSRLEQLCAGQPAELDLVSTDTATARAELDAVEAARIAAEKDCETRRQIAAGAARRLAETSTRATVLQNAAAAESAELGAAMTRLACERASVGDDELAAKAEADLRVLQTAEQRVIDLADELAATAPDAVAAELAEAADAVELLRERHDEAIRALHEVGVELSVFGTQGRKGKLDAAETEREHAASHHARVGRRARAARLLRSVMARHRDTTRLRYVEPYRAELHRLGRPVFGPSFEVEVDTDLRIRSRTLDDRTVPYECLSGGAKEQLGILARLAGAALVAKEDAVPVLIDDALGFTDPERLAKMGEVFDTIGADGQVIVLTCSPTRYGGVKGAHRIDLDAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7C8</accession>
    <name>A0A7U8Y7C8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutaredoxin-like protein NrdH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Electron transport system for the ribonucleotide reductase system NrdEF.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415982.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7C8"/>
    <dbReference type="GeneID" id="45427046"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011909">
        <property type="entry name" value="GlrX_NrdH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02194">
        <property type="entry name" value="GlrX_NrdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="79" mass="8419" checksum="2677CD0EAD3C6B88" modified="2021-06-02" version="1">MTVTVYTKPACVQCSATSKALDKQGIAYQKVDISLDSEARDYVMALGYLQAPVVVAGNDHWSGFRPDRIKALAGAALTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7F9</accession>
    <name>A0A7U8Y7F9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavin-containing monoamine oxidase aofH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03793</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="245" mass="26415" checksum="1C496A0A4316559C" modified="2021-06-02" version="1">MTNPPWTVDVVVVGAGFAGLAAARELTRQGHEVLVFEGRDRVGGRSLTGRVAGVPADMGGSFIGPTQDAVLALATELGIPTTPTHRDGRNVIQWRGSARSYRGTIPKLSLTGLIDIGRLRWQFERIARGVPVAAPWDARRARELDDVSLGEWLRLVRATSSSRNLMAIMTRVTWGCEPDDVSMLHAARYVRAAGGLDRLLDVKNGAQQDRVPGGHSRSPRRPPPNSAHASCSTPRCVASTGTERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7T9</accession>
    <name>A0A7U8Y7T9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain type alcohol dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7T9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="287" mass="31154" checksum="E58046026B6F4F10" modified="2021-06-02" version="1">MLQRGAGQYFAGKRCFVTGAASGIGRATALRLAAQGAELYLTDRDRDGLAQTVCDARALGAQVPEHRVLDVSDYQDVAAFAADIHARHPSMDVVLNIAGVSAWGTVDQLTHDQWSRMVAINLMGPIHVIETLVPPMVAAGRGGHLVNVSSAAGLVGLPWHAAYSASKYGLRGLSEVLRFDLARHGIGVSVVVPGAVKTPLVNTVEIAGVDRDDPRVNRWVERFSGHAVTPEKAADKILAGVTRNRYLVYTSADIRALYAFKRYAWWPYTLVMRRVNVFFTRALRPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7V9</accession>
    <name>A0A7U8Y7V9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02961</name>
        <name evidence="6" type="ORF">TBLG_03738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404293.1">
        <property type="nucleotide sequence ID" value="NZ_KK338673.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7V9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="18"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="160"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="277" mass="31015" checksum="AC37B715D99565A9" modified="2021-06-02" version="1">MARCDVLVSADWAESNLHAPKVVFVEVDEDTSAYDRDHIAGAIKLDWRTDLQDPVKRDFVDAQQFSKLLSERGIANEDTVILYGGNNNWFAAYAYWYFKLYGHEKVKLLDGGRKKWELDGRPLSSDPVSRPVTSYTASPPDNTIRAFRDEVLAAINVKNLIDVRSPDEFSGKILAPAHLPQEQSQRPGHIPGAINVPWSRAANEDGTFKSDEELAKLYADAGLDNSKETIAYCRIGERSSHTWFVLRELLGHQNVKNYDGSWTEYGSLVGAPIELGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7W9</accession>
    <name>A0A7U8Y7W9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="246" mass="26989" checksum="E583C903ED44B3A3" modified="2021-06-02" version="1">MVEAAQRLRYDVFSTTPGFALPAAADTRRDGDRFDEYCDHLLVRDDDTGELVGCYRMLAPAGAIAAGGLYTATEFDVCAFDPLRPSLVEMGRAVVREGHRNGGVVLLMWAGILAYLDRYGYDYVTGCVSVPIGGDGETPGSRLRGVRDFILNRHAAPPQCQVYPYRPVRVDGRSLDDILPPPRPAVPPLMRGYLRLGARACGEPAHDPDFGVGDFCLLLDKDHADTRYLRRLRSVAAASEMVNDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7X9</accession>
    <name>A0A7U8Y7X9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="214" mass="23692" checksum="F88DE85A596B9E7E" modified="2021-06-02" version="1">MEAARRLIARSGADAITMDDVAAAAGVGKGTLFRRFGSRAGLMMVLLDEDERASQQAFLFGPPPLGPDAPPLDRLIAFGRERMRFVHAHHQLLSEANRDPQTRHSAALSVLRTHLRVLLASAPTTGDLDAQTDALLALRRRRRRARAAHPAAVRWAVPGLADRRRRTVRTMIDHYADSSTAMDPARRPRPVFGVGRTAPPPRTGRFAGHRRRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y846</accession>
    <name>A0A7U8Y846_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417908.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y846"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="296" mass="34031" checksum="D79E55CFDE338E07" modified="2021-06-02" version="1">MNLVSEKEFLDLPLVSVAEIVRCRGPKVSVFPFDGTRRWFHLECNPQYDDYQQAALRQSIRILKMLFEHGIETVISPIFSDDLLDRGDRYIVQALEGMALLANDEEILSFYKEHEVHVLFYGDYKKRLPSTAQGAAVVKSFDDLTISTSSNTEHRLCFGVFGNDAAESVAQFSISWNETHGKPPTRREIIEGYYGEYVDKADMFIGFGRFSTFDFPLLSSGKTSLYFTVAPSYYMTETTLRRILYDHIYLRHFRPKPDYSAMSADQLNVLRNRYRAQPDRVFGVGCVHDGIWFAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9X6</accession>
    <name>A0A7U8Y9X6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoserine phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">TBLG_03662</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + O-phospho-D-serine = D-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24873"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58680"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-serine = L-serine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="3.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="6"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415945.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y9X6"/>
    <dbReference type="GeneID" id="45427035"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD14764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="409" mass="43131" checksum="5AD6E99BB342340A" modified="2021-06-02" version="1">MPAKVSVLITVTGMDQPGVTSALFEVLAQHGVELLNVEQVVIRGRLTLGVLVSCPLDVADGTALRDDVAAAIHGVGLDVAIERSDDLPIIRQPSTHTIFVLGRPITAGAFSAVAREVAALGVNIDFIRGISDYPVTGLELRVSVPPGCVGPLQIALTKVAAEEHVDVAVEDYGLAWRTKRLIVFDVDSTLVQGEVIEMLAARAGAQGQVAAITEAAMRGELDFAESLQRRVATLAGLPATVIDDVAEQLELMPGARTTIRTLRRLGFRCGVVSGGFRRIIEPLARELMLDFVASNELEIVDGILTGRVVGPIVDRPGKAKALRDFASQYGVPMEQTVAVGDGANDIDMLGAAGLGIAFNAKPALREVADASLSHPYLDTVLFLLGVTRGEIEAADAGDCGVRRVEIPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA71</accession>
    <name>A0A7U8YA71_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417130.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427274"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="82"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="172" mass="19820" checksum="9BB3AD2FC53CB964" modified="2021-06-02" version="1">MSYPENVLAAGEQVVLHRHPHWNRLIWPVVVLVLLTGLAAFGSGFVNSTPWQQIAKNVIHAVIWGIWLVIVGWLTLWPFLSWLTTHFVVTNRRVMFRHGVLTRSGIDIPLARINSVEFRDRIFERIFRTGTLIIESASQDPLEFYNIPRLREVHALLYHEVFDTLGSDESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF56</accession>
    <name>A0A7U8TF56_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_02702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403007.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF56"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="154"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="463" mass="50509" checksum="9D0B8745F869533A" modified="2021-06-02" version="1">MAIRQHVGALFTDLYEVTMAQAYWAERMSGTAVFEIFFRKLPPGRSYIMAAGLADVVEFLEAFRFDEQDLRYLRGLGQFSDEFLRWLAGVRFTGDVWAAPEGTVIFPNEPAVQLIAPIIEAQLVETFVLNQIHLQSVLASKAARVVAAARGRPVVDFGARRAHGTDAACKVARTSYLAGAAGTSNLLAARQYGIPTFGTMAHSFVQAFDSEVAAFEAFARLYPATMLLVDTYDTLRGVDHVIELAKRLGNRFDVRAVRLDSGDLDELSKATRARLDTAGLEQVEIFASSGLDENRIAALLAARCPIDGFGVGTQLVVAQDAPALDMAYKLVAYDGSGRTKFSSGKVIYPGRKQVFRKLEHGVFCGDTLGEHGENLPGDPLLVPIMTNGRRIRQHAPTLDGARDWARQQIDALPPELRSLEDTGYSYPVAVSDRIVGELARLRHADTAEAHPGSNVVGAKAKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF76</accession>
    <name>A0A7U8TF76_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component system transcriptional regulator tcrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02734</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403148.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF76"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="24"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="146"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="253" mass="28170" checksum="E4F0DA2EA8E1BA18" modified="2021-06-02" version="1">MADETTMRAGRGPGRACGRVSGVRILVVEDEPKMTALLARALTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQRVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRGPIPRPPTLEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRRPGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRPFGVTSLETIRGAGYRLRKDGGRHALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF98</accession>
    <name>A0A7U8TF98_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">secE</name>
        <name evidence="9" type="ORF">TBLG_02775</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="161" mass="16926" checksum="9AC5D894F289784E" modified="2021-06-02" version="1">MSDEGDVADEAVADGAENADSRGSGGRTALVTKPVVRPQRPTGKRSRSRAAGADADVDVEEPSTAASEATGVAKDDSTTKAVSKAARAKKASKPKARSVNPIAFVYNYLKQVVAEMRKVIWPNRKQTLTYTSVVLAFLAFMVALVAGADLGLTKLVMLVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF99</accession>
    <name>A0A7U8TF99_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RecBCD enzyme subunit RecD</fullName>
            <ecNumber evidence="10">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Exonuclease V subunit RecD</fullName>
            <shortName evidence="10">ExoV subunit RecD</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Helicase/nuclease RecBCD subunit RecD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">recD</name>
        <name evidence="12" type="ORF">TBLG_02764</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RecD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="10"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900979.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF99"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009338">
        <property type="term" value="C:exodeoxyribonuclease V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01487">
        <property type="entry name" value="RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006344">
        <property type="entry name" value="RecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041851">
        <property type="entry name" value="RecD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027785">
        <property type="entry name" value="UvrD-like_helicase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13538">
        <property type="entry name" value="UvrD_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01447">
        <property type="entry name" value="recD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD_C_2" evidence="11">
        <location>
            <begin position="499"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="575" mass="61747" checksum="A250708D407DE561" modified="2021-06-02" version="1">MKLTDVDFAVEASGMVRAFNQAGVLDVSDVHVAQRLCALAGESDERVALAVAVAVRALRAGSVCVDLLSIARVAGHDDLPWPDPADWLAAVRASPLLADPPVLHLYDDRLLYLDRYWREEEQVCADLLALLTSRRPAGVPDLRRLFPTGFDEQRRAAEIALSQGVTVLTGGPGTGKTTTVARLLALVAEQAELAGEPRPRIALAAPTGKAAARLAEAVRREMAKLDATDRARLGDLHAVTLHRLLGAKPGARFRQDRQNRLPHNVIVVDETSMVSLTLMARLAEAVRPGARLILVGDADQLASVEAGAVLADLVDGFSVRDDALVAQLRTSHRFGKVIGTLAEAIRAGDGDAVLGLLRSGEERIEFVDDEDPAPRLRAVLVPHALRLREAALLGASDVALATLDEHRLLCAHRDGPTGVLHWNRRVQAWLAEETGQPPWTPWYAGRPLLVTANDYGLRVYNGDTGVVLAGPTGLRAVISGASGPLDVATGRLGDVETMHAMTIHKSQGSQVDEVTVLMPQEDSRLLTRELLYTAVTRAKRKVRVVGSEASVRAAIARRAVRASGLRMRLQSTGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFE9</accession>
    <name>A0A7U8TFE9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFE9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023981">
        <property type="entry name" value="MftF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43646:SF6">
        <property type="entry name" value="PTHR43646:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03965">
        <property type="entry name" value="mycofact_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="85"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="470" mass="50667" checksum="D2D6AC3F43D77414" modified="2021-06-02" version="1">MTATRLPDGFAVQVDRRVRVLGDGSALLGGSPTRLLRLAPAARGLLCDGRLKVRDEVSAELARILLDATVAHPRPPSGPSHRDVTVVIPVRNNASGLRRLVTSLRGLRVIVVDDGSACPVESDDFVGAHCDIEVLHHPHSKGPAAARNTGLAACTTDFVAFLDSDVTPRRGWLESLLGHFCDPTVALVAPRIVSLVEGENPVARYEALHSSLDLGQREAPVLPHSTVSYVPSAAIVCRSSAIRDVGGFDETMHSGEDVDLCWRLIEAGARLRYEPIALVAHDHRTQLRDWIARKAFYGGSAAPLAVRHPDKTAPLVISGGALMAWILMSIGTGLGRLASLVIAVLTGRRIARAMRCAETSFLDVLAVATRGLWAAALQLASAICRHYWPLALLAAILSRRCRRVVLIAAVVDGVVDWLRRREGADDDAEPIGPLTYLVLKRVDDLAYGAGLWYGVVRERNIGALKPQIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFH9</accession>
    <name>A0A7U8TFH9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403733.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFH9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="zf-HC2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="250" mass="25938" checksum="D7FB0253C04F9064" modified="2021-06-02" version="1">MTMPLRGLGPPDDTGVREVSTGDDHHYAMWDAAYVLGALSAADRREFEAHLAGCPECRGAVTELCGVPALLSQLDRDEVAAISESAPTVVASGLSPELLPSLLAAVHRRRRRTRLITWVASSAAAAVLAIGVLVGVQGHSAAPQRAAVSALPMAQVGTQLLASTVSISGEPWGTFINLRCVCLAPPYASHDTLAMVVVGRDGSQTRLATWLAEPGHTATPAGSISTPVDQIAAVQVVAADTGQVLLQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFJ1</accession>
    <name>A0A7U8TFJ1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Acyl-CoA:diacylglycerol acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.122</ecNumber>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_02920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:23472"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:18195"/>
            <dbReference type="ChEBI" id="CHEBI:18234"/>
            <dbReference type="EC" id="2.3.1.122"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the mycobacterial A85 antigen family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.122" evidence="4"/>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403938.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFJ1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030835479" description="Acyl-CoA:diacylglycerol acyltransferase" evidence="8">
        <location>
            <begin position="30"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="303" mass="30654" checksum="BD2AD4EE7C2CE63D" modified="2021-06-02" version="1">MMARMPELSRRAVLGLGAGTVLGATSAYAIDMLLQPRTSHAAPAAAIGTNVPLAPTPALDPAPPAQAAPTMSTGSFVSAARAGKMTNWAIARPPGQTQALRPVIALHGLGGSASAVMDGGVEQGLAQAVNAGLPPFAVVSVDGGSSYWHQRASGEDAGAMVLNELIPLLDTQRLDTSRVAFLGWSMGGYGALLLGSRLGPARTAAICAVSPALWLSAGSVAPGSFDGPDDWSANSVFGLPALGSIPIRVDCGNSDPFYAATKQFVAQLPHPPAGGFSPGGHNGGFWSAQLPAELTWFAPLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFJ2</accession>
    <name>A0A7U8TFJ2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase NAD-dependent aldA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403919.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFJ2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026460">
        <property type="entry name" value="Aldehyde_dehydrogenase_Rv0768"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04284">
        <property type="entry name" value="aldehy_Rv0768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="21"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="489" mass="51184" checksum="2E2E797008030738" modified="2021-06-02" version="1">MALWGDGISALLIDGKLSDGRAGTFPTVNPATEEVLGVAADADAEDMGRAIEAARRAFDSTDWSRNTELRVRCVRQLRDAMQQHVEELRELTISEVGAPRMLTASAQLEGPVGDLSFAADTAESYPWKQDLGEASPLGIATRRTLAREAVGVVGAITPWNFPHQINLAKLGPALAAGNTVVLKPAPDTPWCAAALGEIIVEHTDFPPGVVNIVTSSSHALGALLAKDPRVDMISFTGSTATGRAVMADAAATIKKVFLELGGKSAFVVLDDADLAAASAVSAFSACMHAGQGCAITTRLVVPRARYEEAVAIAAATMSSIRPGDPNDPGTVCGPLISARQRDRVQGYLDLAVAEGGRFACGGARPADREVGFYIEPTVIAGLTNDARVAREEIFGPVLTVIAHDGDDDAVRIANDSPYGLSGTVYGADPQRAARIASRLRVGTVNVNGGVWYCADAPFGGYKQSGIGREMGLLGFEEYLEAKLIATAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFJ6</accession>
    <name>A0A7U8TFJ6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403477.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011200">
        <property type="entry name" value="UCP012608"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10094">
        <property type="entry name" value="DUF2332"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012608">
        <property type="entry name" value="UCP012608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="349" mass="38130" checksum="57A8964DD93A55D2" modified="2021-06-02" version="1">MTGTEHLVHTLRSQGRVCTSSGSPMYRELLELVAADVESGGVFASILADQKGAPEGQAVPLRLLGGLHRMVLDGRAPVLRRWYPSTGGTWQAEAAWPDIVRTATDQPESLRAALDRPPQTNEVGRSAALIGGLLIACLQFDLPIRLFEIGSSAGLNLRPDRYRYRYLGGEWGLADSPVRIDNAWLGELPPTATVRIVERHGYDIAPIDVTSPDGELNALSYIWPDQTDRLERLRGAIAVARNIPADLHRQAAHAAVAGMTLTDDALTVLWHSITWQYLPADERAAIRAGIDALAAQADAHCPFVHLTLEPAHQRPGAQIKYLVRMRSWPGGHARVLGECHPHGPPVTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFK5</accession>
    <name>A0A7U8TFK5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protease II ptrBb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023302">
        <property type="entry name" value="Pept_S9A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002470">
        <property type="entry name" value="Peptidase_S9A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02897">
        <property type="entry name" value="Peptidase_S9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00862">
        <property type="entry name" value="PROLIGOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S9" evidence="1">
        <location>
            <begin position="312"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="547" mass="60425" checksum="AB811AC9D02F2E13" modified="2021-06-02" version="1">MRFKDLRTGEQYPDEIAGIGAGVTWAADNRTVYYTTVDAAWRPDTVWRYRLGSGESSERVYHEADDRFWLAVGRTRSNAYLLIAAGSSITSEVRYAHAADPTAQFSVVLPRRDGVEYSVEHAVIAGQDRFLILHNDGAVNFTLVEAPVEDPARQRTLIAHRDDVRLDAVDALAGHLVVSYRREALPRVQLWPIGPDGNYGEPEEISFDSELMSAGLGPNPNWDSPKLRVGAGSFVTPVRIYDIDLVTGERTLLKEQPVLGGYRREDYVERRDWAYGDDGTRIPVSIVHRADIEFPAPALIYGYGAYEICEDPRFSIARLSLLDRGMVFVVAHVRGGGEMGRLWYENGKLLDKKNTFTDFIAVARHLVDTGLTSQQQLVALGGSAGGLLMGAVANMAPDLFAGILAQVPFVDPLTTILDPSLPLTVTEWDEWGNPLNDSDVYAYVKSYSPYENVTAQKYPAILAMTSLNDTRVYYVEPAKWVAALRHAKTDGNSVLLKTQMHAGHGGISGRYERWKETAFQYGWLLATADSDRYGGGQGNDLDGAAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFK9</accession>
    <name>A0A7U8TFK9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplF</name>
        <name evidence="7" type="ORF">TBLG_02863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403673.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFK9"/>
    <dbReference type="GeneID" id="45424684"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="11"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="6">
        <location>
            <begin position="91"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="179" mass="19377" checksum="70C5F357B7C452E9" modified="2021-06-02" version="1">MSRIGKQPIPVPAGVDVTIEGQSISVKGPKGTLGLTVAEPIKVARNDDGAIVVTRPDDERRNRSLHGLSRTLVSNLVTGVTQGYTTKMEIFGVGYRVQLKGSNLEFALGYSHPVVIEAPEGITFAVQAPTKFTVSGIDKQKVGQIAANIRRLRRPDPYKGKGVRYEGEQIRRKVGKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFM5</accession>
    <name>A0A7U8TFM5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="3 12">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 12">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 12">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">purM</name>
        <name evidence="15" type="ORF">TBLG_02955</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="3 12"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404132.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFM5"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="13">
        <location>
            <begin position="70"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="14">
        <location>
            <begin position="186"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD12371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="364" mass="38393" checksum="9ECF162DE6C59A92" modified="2021-06-02" version="1">MTDLAKGPGKDPGSRGITYASAGVDIEAGDRAIDLFKPLASKATRPEVRGGLGGFAGLFTLRGDYREPVLAASSDGVGTKLAIAQAMDKHDTVGLDLVAMVVDDLVVCGAEPLFLLDYIAVGRIVPERLSAIVAGIADGCMRAGCALLGGETAEHPGLIEPDHYDISATGVGVVEADNVLGPDRVKPGDVIIAMGSSGLHSNGYSLVRKVLLEIDRMNLAGHVEEFGRTLGEELLEPTRIYAKDCLALAAETRVRTFCHVTGGGLAGNLQRVIPHGLIAEVDRGTWTPAPVFTMIAQRGRVRRTEMEKTFNMGVGMIAVVAPEDTTRALAVLTARHLDCWVLGTVCKGGKQGPRAKLVGQHPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFQ5</accession>
    <name>A0A7U8TFQ5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014513">
        <property type="entry name" value="UCP021525"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021525">
        <property type="entry name" value="UCP021525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="271" mass="29671" checksum="5727B2D2B3259277" modified="2021-06-02" version="1">MSDSPDYDPVLLAWVTPIVTALADVVPAEQLMLVGAQCRDLLHWRFCRGVPPRATNDTDIAGTLNNWDHFEAIRATFRALGSTGHRFLIADRAVDALPFGEVESPTGTTRHPPGNQLMNVHGCTDAYLRADVLPLPGGLTVHLPQPPNYAVLKLHAWLDRSADHDYKDGPDLALVVHWYAGDLDRLYAKPDQWALRRHDFDLRTAAAALLGHDMRASVSAPEAAVLATRATQADHDLLAQHFAVGRPGWPTTTASRRPLVEALLDQLTPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFQ6</accession>
    <name>A0A7U8TFQ6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SCP_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404127.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFQ6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041629">
        <property type="entry name" value="SCP_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17844">
        <property type="entry name" value="SCP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SCP_3" evidence="1">
        <location>
            <begin position="34"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="129" mass="13480" checksum="F686B14ED7C59CE4" modified="2021-06-02" version="1">MSARDRVDPAKTRQVVLALADWLRDETLPAPDTDVLAAAVRLTARTLAALAPGASVEVRIPPFAAVQCISGPRHTRGTPPNVVQTDPRTWLLVATGLSGVAQARGSGALQLSGSRAGEIEAWLPLVDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFR4</accession>
    <name>A0A7U8TFR4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="110" mass="12384" checksum="35023972E9A31153" modified="2021-06-02" version="1">MTRDPHSPDCGREGSYRDTITRPLTDLPVAGYPLVPRVASPRYRCTTPQCGRAVFNQDLANVDQYLVVNQLAHQLIDGSSLIPDADKRWDARRHADMTHHLTSSLKENQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFU6</accession>
    <name>A0A7U8TFU6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metal cation transporting P-type ATPase ctpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898639.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFU6"/>
    <dbReference type="GeneID" id="45424871"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="667"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="797" mass="84973" checksum="4C5034FC6052FC7B" modified="2021-06-02" version="1">MTRSASATAGLTDAEVAQRVAEGKSNDIPERVTRTVGQIVRANVFTRINAILGVLLLIVLATGSLINGMFGLLIIANSVIGMVQEIRAKQTLDKLAIIGQAKPLVRRQSGTRTRSTNEVVLDDIIELGPGDQVVVDGEVVEEENLEIDESLLTGEADPIAKDAGDTVMSGSFVVSGAGAYRATKVGSEAYAAKLAAEASKFTLVKSELRNGINRILQFITYLLVPAGLLTIYTQLFTTHVGWRESVLRMVGALVPMVPEGLVLMTSIAFAVGVVRLGQRQCLVQELPAIEGLARVDVVCADKTGTLTESGMRVCEVEELDGAGRQESVADVLAALAAADARPNASMQAIAEAFHSPPGWVVAANAPFKSATKWSGVSFRDHGNWVIGAPDVLLDPASVAARQAERIGAQGLRVLLLAAGSVAVDHAQAPGQVTPVALVVLEQKVRPDARETLDYFAVQNVSVKVISGDNAVSVGAVADRLGLHGEAMDARALPTGREELADTLDSYTSFGRVRPDQKRAIVHALQSHGHTVAMTGDGVNDVLALKDADIGVAMGSGSPASRAVAQIVLLNNRFATLPHVVGEGRRVIGNIERVANLFLTKTVYSVLLALLVGIECLIAIPLRRDPLLFPFQPIHVTIAAWFTIGIPAFILSLAPNNERAYPGFVRRVMTSAVPFGLVIGVATFVTYLAAYQGRYASWQEQEQASTAALITLLMTALWVLAVIARPYQWWRLALVLASGLAYVVIFSLPLAREKFLLDASNLATTSIALAVGVVGAATIEAMWWIRSRMLGVKPRVWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFW7</accession>
    <name>A0A7U8TFW7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03056</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404689.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFW7"/>
    <dbReference type="GeneID" id="45424865"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="237"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="446" mass="47829" checksum="CD84A335CCFFE6D7" modified="2021-06-02" version="1">MNILSRIFARTPSLRTRVVVATAIGAAIPVLIVGTVVWVGITNDRKERLDRRLDEAAGFAIPFVPRGLDEIPRSPNDQDALITVRRGNVIKSNSDITLPKLQDDYADTYVRGVRYRVRTVEIPGPEPTSVAVGATYDATVAETNNLHRRVLLICTFAIGAAAVFAWLLAAFAVRPFKQLAEQTRSIDAGDEAPRVEVHGASEAIEIAEAMRGMLQRIWNEQNRTKEALASARDFAAVSSHELRTPLTAMRTNLEVLSTLDLPDDQRKEVLNDVIRTQSRIEATLSALERLAQGELSTSDDHVPVDITDLLDRAAHDAARIYPDLDVSLVPSPTCIIVGLPAGLRLAVDNAIANAVKHGGATLVQLSAVSSRAGVEIAIDDNGSGVPEGERQVVFERFSRGSTASHSGSGLGLALVAQQAQLHGGTASLENSPLGGARLVLRLPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG16</accession>
    <name>A0A7U8TG16_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031175942" description="PE domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="3">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="420" mass="37394" checksum="9B494BDFDDB93822" modified="2021-06-02" version="1">MLCRPQEVSAMSFVVTAPPVLASAASDLGGIASMISEANAMAAVRTTALAPAAADEVSAAIAALFSSYARDYQTLSVQVTAFHVQFAQTLTNAGQLYAVVDVGNGVLLKTEQQVLGVINAPTQTLVGRPLIGDGTHGAPGTGQNGGAGGILWGNGGNGGSGAPGQPGGRGGDAGLFGHGGHGGVGGPGIAGAAGTAGLPGGNGANGGSGGIGGAGGAGGNGGLLFGNGGAGGQGGSGGLGGSGGTGGAGMAAGPAGGTGGIGGIGGIGGAGGVGGHGSALFGHGGINGDGGTGGMGGQGGAGGNGWAAEGITVGIGEQGGQGGDGGAGGAGGIGGSAGGIGGSQGAGGHGADGGQGGAGGSGRVGGGCAGSGANGGEIGISRTGRNCSLDGTARNDRNRRRGGSGAMTTEGSDESMSACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG48</accession>
    <name>A0A7U8TG48_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdpC</name>
        <name evidence="12" type="ORF">TBLG_03197</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 11" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="169" mass="17928" checksum="71D31C7C9412EA5B" modified="2021-06-02" version="1">GIVYPLRDRVGQLFFGDQANGALLERDGQVIGSAHIGQQFTAAKYFHPRPSSAGDGYDAAASSGSNLGPTNEKLLAAVAERVTAYRKENNLPADTLVPVDAVTGSGSGLDPAISVVNAKLQAPRVAQARNISIRQVERLIEDHTDARGLGFLGERAVNVLRLNLALDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG53</accession>
    <name>A0A7U8TG53_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpA</name>
        <name evidence="10" type="ORF">TBLG_03195</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405318.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG53"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="538"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="571" mass="60163" checksum="4A3238D1C62A3687" modified="2021-06-02" version="1">MSGTSWLQFAALIAVLLLTAPALGGYLAKIYGDEAKKPGDRVFGPIERVIYQVCRVDPGSEQRWSTYALSVLAFSVMSFLLLYGIARFQGVLPFNPTDKPAVTDHVAFNAAVSFMTNTNWQSYSGEATMSHFTQMTGLAVQNFVSASAGMCVLAALIRGLARKRASTLGNFWVDLARTVLRIMFPLSFVVAILLVSQGVIQNLHGFIVANTLEGAPQLIPGGPVASQVAIKQLGTNGGGFFNVNSAHPFENYTPIGNFVENWAILIIPFALCFAFGKMVHDRRQGWAVLAIMGIIWIGMSVAAMSFEAKGNPRLDALGVTQQTTVDQSGGNLEGKEVRFGVGASGLWAASTTGTSNGSVNSMHDSYTPLGGMVPLAHMMLGEVSPGGTGVGLNGLLVMAILAVFIAGLMVGRTPEYLGKKIQATEMKLVTLYILAMPIALLSFAAASVLISSALASRNNPGPHGLSEILYAYTSGANNNGSAFAGLTASTWSYDTTIGVAMLIGRFFLIIPVLAIAGSLARKGTTPVTAATFPTHKPLFVGLVIGVVLIVGGLTFFPALALGPIVEQLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG63</accession>
    <name>A0A7U8TG63_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405517.1">
        <property type="nucleotide sequence ID" value="NZ_KK338665.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG63"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025159">
        <property type="entry name" value="AbiEi_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13338">
        <property type="entry name" value="AbiEi_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="207" mass="22532" checksum="92ED3553A4299CF9" modified="2021-06-02" version="1">MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAVSWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTGTDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG76</accession>
    <name>A0A7U8TG76_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="103" mass="11013" checksum="102C7249BEE8195B" modified="2021-06-02" version="1">MTTAGISGSKGRTGTGEPVRSAVCGRVSRWRVRWVDGGGEEHSKSFQRKPDAQVPDPCRTVDARQGHGPVRNAHLGARLLRLTAVYGSVRLLPCGASMWGIAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG85</accession>
    <name>A0A7U8TG85_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG85"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="144" mass="15376" checksum="8201C5443BFCCAFF" modified="2021-06-02" version="1">MSYMIATPAALTAAATDIDGIGSAVSVANAAAVAATTGVLAAGGDEVLAAIARLFNANAEEYHALSAQVAAFQTLFVRTLTGGCGVFRRRRGRQCVTAAEHRAAGAGRRQRRRRSGDGQWRLRQQRHFGCGGQPEFRQHSEHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGC5</accession>
    <name>A0A7U8TGC5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epoxide hydrolase ephC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGC5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="316" mass="34695" checksum="828D91DCF60CBC7D" modified="2021-06-02" version="1">MRAGRGERESTWRTTMAEPHWIDVKGPNGDLKALTWGPAGAPVALCLHGFPDTAYGWRKVAPRLAESGWHVVAPFMRGYAPSSIPADGSYHVGALMHDALRVRSAAGGTERDVIIGHDWGAIAATGLAAMPDSPFAKAVIMSVPPSAAFRPLGRVPERGRLLRELPHQLLRSWYILYFQLPWLPERSASWVVPLLWRRWSPGYHAEEDLRHVDAAIGTPEGRRAALGPYRATMRNTRAPADYADLNRLWTEAPKLPVLYLHGHDDGCATSAFTHWTARVLPAGSEVAVVEHAGHFLQLEQPDKIAELIVAFIGSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGF1</accession>
    <name>A0A7U8TGF1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406189.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="939" mass="100674" checksum="F4AAA3147E04FCA3" modified="2021-06-02" version="1">MDPHRDLESRAFAGNWRVYQQQALDAFDADVAAGDNRAYLVLPPGAGKTMIGLEAARRLGRRSLVLVPNTAVQAQWAAAWDNSFPSSDRSASKCGTERGLASAMNVLTYQSLAVIDAETDSTVRREVLRNRDQQALLDLLHPNGRAVIERAATLGPWTLVLDECHHLLATWGALVSALASVLGAQTALIGLTATPATELTAWQHTLHDELFGTADFVIPTPALVREGDLAPYQELVYLTQPTPEEQAWIGTHRARFADLMLALIDQKVGSMSLAAWLHTRIVDRATREGNQIAWSTFERAEPDLACSGLRFAYDGLIPLPDGVRLREQHRIAPDAQDWVNVLTDFSVGHLQQSADPRDAHALTAIKRVLPGLGYRLTSRGVRVATSPVDRLCALSESKIAATAHILDTEDAVLGARLRALVLCDFESMTGALPTSLKGAPVSEQSGSAQLVAAMLAASDHRRRTPLHALLVTGQTFACPAAIEDDLIAFCAERGALVTAEPLDAHPSLRVMRGTGGFTPRTWVALATEYFLAGRARVLVGTRSLLGEGWDCAAVNVNIDLTSATTQAAITQMRGRAIRNDPSDGHKVADNWSVCCIATEHPRGDADYLRLVRKHDGYYAATPQGLIESGVTHCDPSLSPYGPPVTDTHAITARALQRVAERAQARSWWRIGEPYEGVDVATIRVRSRQPLGVAAPRIPASALTPPVPGQFSPVRLARGAVAAVSVVGASTATAVASANLGMLAGAGTAGAIVAAGVGLVATAAAAESRRLDHAPNALEQLAAVVADALYAAGGAQRGSAALRLASDPEGWIRCQLDGVPTEQSLRFTAALDELLAPLAEPRYLIGRKILTPPARPVARRLFAVRAVVGLSLPGTVAWHAVPRWFARNKDRRQHLAQAWRKHIGPPRQLPADSPQGQAILDLFRGDNPLSVTTQLRTTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGK9</accession>
    <name>A0A7U8TGK9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 130 cyp130</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGK9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="405" mass="44581" checksum="72DEAE6CB688FA48" modified="2021-06-02" version="1">MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEYDYYVLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRKLVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPEEDWTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVAAGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGIPDAVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAELDVTRCPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSYVRRPLSVPFRVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGM0</accession>
    <name>A0A7U8TGM0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03447</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031326">
        <property type="term" value="P:regulation of cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="292"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="576" mass="61643" checksum="7491AC0EBF5B4505" modified="2021-06-02" version="1">MSDAQDSRVGSMFGPYHLKRLLGRGGMGEVYEAEHTVKEWTVAVKLMTAEFSKDPVFRERMKREARIAGRLQEPHVVPIHDYGEVDGQMFLEMRLVEGTDLDSVLKRFGPLTPPRAVAIITQIASALDAAHADGVMHRDVKPQNILITRDDFAYLVDFGIASATTDEKLTQLGTAVGTWKYMAPERFSNDEVTYRADIYALACVLHECLTGAPPYRADSAGTLVSSHLMGPIPQPSAIRPGIPKAFDAVVARGMAKKPEDRYASAGDLALAAHEALSDPDQDHAADILRRSQESTLPGTAAVTAQPPTMPTVTPPPIQAAPTGQPSWAPNSGPMPASGPTPTPQYYQGGGWGAPPSGGPSPWAQTPRKTNPWPFVAVAAAVVLVLVLGAIGIWIANRPDDNPKRNIATSPGTPTTTATTSLPATTTPTTAPASDPQTRLLSMLPSGYPTGTCKPTTPKPNSIWVNAVAMVDCGQNTNQGGPSRAIYGLFANPDKLKQAFNDDIAAVELMNCPGEGPSPDGWHYNQTPDVTAGMIACGTYKNRPNVIWSNEAKLTLSDVFGDPATIEDLHNWWAKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGN4</accession>
    <name>A0A7U8TGN4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">atpG</name>
        <name evidence="10" type="ORF">TBLG_03491</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898819.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGN4"/>
    <dbReference type="GeneID" id="45425283"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="305" mass="33890" checksum="37AB5B6258330427" modified="2021-06-02" version="1">MAATLRELRGRIRSAGSIKKITKAQELIATSRIARAQARLESARPYAFEITRMLTTLAAEAALDHPLLVERPEPKRAGVLVVSSDRGLCGAYNANIFRRSEELFSLLREAGKQPVLYVVGRKAQNYYSFRNWNITESWMGFSEQPTYENAAEIASTLVDAFLLGTDNGEDQRSDSGEGVDELHIVYTEFKSMLSQSAEAHRIAPMVVEYVEEDIGPRTLYSFEPDATMLFESLLPRYLTTRVYAALLESAASELASRQRAMKSATDNADDLIKALTLMANRERQAQITQEISEIVGGANALAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGQ2</accession>
    <name>A0A7U8TGQ2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">9.5 kDa culture filtrate antigen cfp10a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="93" mass="9587" checksum="CA53151BDD3742A8" modified="2021-06-02" version="1">MNVTVSIPTILRPHTGGQKSVSASGDTLGAVISDLEANYSGISERLMDPSSPGKLHRFVNIYVNDEDVRFSGGLATAIADGDSVTILPTVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGS8</accession>
    <name>A0A7U8TGS8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RelA_SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03553</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407164.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGS8"/>
    <dbReference type="GeneID" id="45425346"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RelA_SpoT" evidence="1">
        <location>
            <begin position="76"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="273" mass="30132" checksum="BCD66B318BE0B887" modified="2021-06-02" version="1">MVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKSQDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVEIQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMALGEASKNKATVLATTKFRLERAINEAESAGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGU6</accession>
    <name>A0A7U8TGU6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotase</fullName>
            <shortName evidence="5">DHOase</shortName>
            <ecNumber evidence="5">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrC</name>
        <name evidence="7" type="ORF">TBLG_03567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="5"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407204.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGU6"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="6">
        <location>
            <begin position="48"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="59"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="322"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="430" mass="45192" checksum="05065892995885F5" modified="2021-06-02" version="1">MSVLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAIPDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEMGMMNAGAAQVRMFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEILKWAKDQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALRQALADGIIDCVATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGADLASRSANTPFESMSLPATVTATLLRGKVTARDGKIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH96</accession>
    <name>A0A7U8TH96_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02747</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898526.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424574"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="201" mass="22255" checksum="190EBA095C804A13" modified="2021-06-02" version="1">MLGPIRQPRLTVRPGRLPGMIAGVAAKRMNREQFFRAASGLDEDRLRKALWNLYWRGTANMRERIEAELASAGRARPARKIKPPADPDIVGWEVDEFVSLARSGAYLGGDRRVSPRERSRWRFTFKRLAAEAQDALRAEDAEPAASALEQLIDLAREADGYDYFRSDDPVAAAGFVVSDVAAAGHPHFREFAAEIGAAIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THD1</accession>
    <name>A0A7U8THD1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="104" mass="11625" checksum="2B6BEB963D47DFF6" modified="2021-06-02" version="1">MFSVKGEEGKQALDRWISWARRCRIPVFVELAGGIVRHRQAIDAALDHGLWQGLIESTNTKIRLLTRIAFGFRSPEALIALAMLALGGRRPALPGRTKHPRISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THG0</accession>
    <name>A0A7U8THG0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpsC</name>
        <name evidence="13" type="ORF">TBLG_02851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 10">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403590.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THG0"/>
    <dbReference type="GeneID" id="45424672"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="12">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="274" mass="30020" checksum="F109494401A53E15" modified="2021-06-02" version="1">MGQKINPHGFRLGITTDWKSRWYADKQYAEYVKEDVAIRRLLSSGLERAGIADVEIERTRDRVRVDIHTARPGIVIGRRGTEADRIRADLEKLTGKQVQLNILEVKNPESQAQLVAQGVAEQLSNRVAFRRAMRKAIQSAMRQPNVKGIRVQCSGRLGGAEMSRSEFYREGRVPLHTLRADIDYGLYEAKTTFGRIGVKVWIYKGDIVGGKRELAAAAPAGADRPRRERPSGTRPRRSGASGTTATGTDAGRAAGGEEAAPDAAAPVEAQSTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THG2</accession>
    <name>A0A7U8THG2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="7">GPI</shortName>
            <ecNumber evidence="7">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphoglucose isomerase</fullName>
            <shortName evidence="7">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphohexose isomerase</fullName>
            <shortName evidence="7">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgi</name>
        <name evidence="10" type="ORF">TBLG_03104</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THG2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4 7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="553" mass="59974" checksum="FB57DFFD16386AE4" modified="2021-06-02" version="1">MTSAPIPDITATPAWDALRRHHDQIGNTHLRQFFADDPGRGRELTVSVGDLYIDYSKHRVTRETLALLIDLARTAHLEERRDQMFAGVHINTSEDRAVLHTALRLPRDAELVVDGQDVVTDVHAVLDAMGAFTDRLRSGEWTGATGKRISTVVNIGIGGSDLGPVMVYQALRHYADAGISARFVSNVDPADLIATLADLDPATTLFIVASKTFSTLETLTNATAARRWLTDALGDAAVSRHFVAVSTNKRLVDDFGINTDNMFGFWDWVGGRYSVDSAIGLSLMTVIGRDAFADFLAGFHIIDRHFATAPLESNAPVLLGLIGLWYSNFFGAQSRTVLPYSNDLSRFPAYLQQLTMESNGKSTRADGSPVSADTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFAQPLDDLPTAEGTGSMHDLLMSNFFAQTQVLAFGKTAEEIAADGTPAHVVAHKVMPGNRPSTSILASRLTPSVLGQLIALYEHQVFTEGVVWGIDSFDQWGVELGKTQAKALLPVITGAGSPPPQSDSSTDGLVRRYRTERGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THG8</accession>
    <name>A0A7U8THG8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpmD</name>
        <name evidence="8" type="ORF">TBLG_02866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403683.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THG8"/>
    <dbReference type="GeneID" id="45424687"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_L30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L30" evidence="7">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="65" mass="7347" checksum="7BF451DA23AE298A" modified="2021-06-02" version="1">MSQLKITQVRSTIGARWKQRESLRTLGLRRIRHSVIREDNAATRGLIAVVRHLVEVEPAQTGGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THI5</accession>
    <name>A0A7U8THI5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyl-/propionyl-CoA carboxylase beta subunit accD2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03134</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="2">
        <location>
            <begin position="20"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="3">
        <location>
            <begin position="270"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="529" mass="56227" checksum="41C58B39AECB937E" modified="2021-06-02" version="1">MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHALISGLADYFALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEAESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THR3</accession>
    <name>A0A7U8THR3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="59" mass="6394" checksum="E9CCD45DF5205B9F" modified="2021-06-02" version="1">MGILDKVKNLLSQNADKVETVINKAGEFVDEQTQGNYSDAIHKLQDAASNVVGMSDQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIA4</accession>
    <name>A0A7U8TIA4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="561" mass="59132" checksum="D734AF6344B6960D" modified="2021-06-02" version="1">MRVWKHVEAAVDSPDRCGVVLVGPHGVGKTLLAQPAEQVMSEDGRSGRARWVVGTAPGRAIPFGAFRHLISLPASGADIGRPAALLRAARSSLTGDAGDLLLVVDDAHNLDPLSATLVYQLARAGAARLVVTVASEAEPPDAIAALWSDDLLTRVAIEPLDRAQTAAFVESALDATLDVADADELFRRSLGNPLYLRHLIDGGGLEHVDGRWRCRDEDRRPLSGVIDEYLCALPEPARAVVDYLAIAEPLARTDLVALVGGEQLDTLGQAEAAGAVRVGPDSDTSEIFVGHPLYADRARAVLTAEHAHALRVSLVAQLAKHPSDHVSDQLRLSSLAIDVPASATPAAVTDAATAAGQALRLGDVRLAERLARAALDRSDALAARLPLAYALGWQGRGREADAVLAAVNPAELTETELMAWAIPRAANRFWMLNEPERATAFLQTTRSRVTEPTARSTLDALAATFAMNSGNLPRAITLATEVLSGPAADDMAVAWAASAAALSSARMGRFGDVDRLAERASAAEHPGLLRFTVGLAQITSLLLAGDVAPAQELAKRFTDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIA5</accession>
    <name>A0A7U8TIA5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898752.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIA5"/>
    <dbReference type="GeneID" id="45425141"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="100" mass="10872" checksum="82F436818463A897" modified="2021-06-02" version="1">MSFVTTRPDSIGETAANLHEIGVTMSAHDDGVTPLITNVESPAHDLVSIVTSMLFSMHGELYKAIARQAHVIHESFVQTLQTSKTSYWLTELANRAGTST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIC4</accession>
    <name>A0A7U8TIC4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406288.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425203"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025241">
        <property type="entry name" value="DUF4190"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13828">
        <property type="entry name" value="DUF4190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4190" evidence="3">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="198" mass="19899" checksum="7614F59B71C56A62" modified="2021-06-02" version="1">MTAPSGSSGESAHDAAGGPPPVGERPPEQPIADAPWAPPASSPMANHPPPAYPPSGYPPAYQPGYPTGYPPPMPPGGYAPPGYPPPGTSSAGYGDIPYPPMPPPYGGSPGGYYPEPGYLDGYGPSQPGMNTMALVSLISALVGVLCCIGSIVGIVFGAIAINQIKQTREEGYGLAVAGIVIGIATLLVYMIAGIFAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TII7</accession>
    <name>A0A7U8TII7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="2">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Sulfate adenylate transferase</fullName>
            <shortName evidence="2">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cysD</name>
        <name evidence="4" type="ORF">TBLG_03466</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="2"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406618.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425257"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00064">
        <property type="entry name" value="Sulf_adenylyltr_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="3">
        <location>
            <begin position="63"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="332" mass="37513" checksum="373C2D63E0D990A1" modified="2021-06-02" version="1">MAITINMVNPTGFIRYEDVEQEAMTSDVTVGPAPGQYQLSHLRLLEAEAIHVIREVAAEFERPVLLFSGGKDSIVMLHLALKAFRPGRLPFPVMHVDTGHNFDEVIATRDELVAAAGVRLVVASVQDDIDAGRVVETIPSRNPIQTVTLLRAIRENQFDAAFGGARRDEEKARAKERVFSFRDEFGQWDPKAQRPELWNLYNGRHHKGEHIRVFPLSNWTEFDIWSYIGAEQVRLPSIYFAHRRKVFQRDGMLLAVHRHMQPRADEPVFEATVRFRTVGDVTCTGCVESSASTVAEVIAETAVARLTERGATRADDRISEAGMEDRKRQGYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TII8</accession>
    <name>A0A7U8TII8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 9">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03515</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="9">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 9"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900321.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TII8"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 9" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="12">
        <location>
            <begin position="22"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="149"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="357"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="448" mass="47241" checksum="E3F926EE7EA35CE9" modified="2021-06-02" version="1">MGPPPAARRREGEPDNQDPAGLLTDKYELTMLAAALRDGSANRPTTFEVFARRLPTGRRYGVVAGTGRLLEALPQFRFDADACELLAQFLDPATVRYLREFRFRGDIDGYAEGELYFPGSPVLSVRGSFAECVLLETLVLSIFNHDTAIASAAARMVSAAGGRPLIEMGSRRTHERAAVAAARAAYIAGFAASSNLAAQRRYGVPAHGTAAHAFTMLHAQHGGPTELAERAAFRAQVEALGPGTTLLVDTYDVTTGVANAVAAAGAELGAIRIDSGELGVLARQAREQLDRLGATRTRIVVSGDLDEFSIAALRGEPVDSYGVGTSLVTGSGAPTANMVYKLVEVDGVPVQKRSSYKESPGGRKEALRRSRATGTITEELVHPAGRPPVIVEPHRVLTLPLVRAGQPVADTSLAAARQLVASGLRSLPADGLKLAPGEPAIPTRTIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR69</accession>
    <name>A0A7U8TR69_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alkyldihydroxyacetonephosphate synthase agpS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899914.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR69"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="90"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="527" mass="56521" checksum="BA13CC3F70D00459" modified="2021-06-02" version="1">MRSWWGWGTVEDALSDQETQALQSRVAALVSGHDLSDHPPPDLTALGLAAPRVSPPASLAALCSSDLVDRAGHARGKAYRDIARNLQGQLDHLPDLIARPRSEQDVIDVLDWCAREGIAVIPYGGGSSVVGGVEPRFDEPVVTVDVTAMSAVLEIDRVSRAARIQAGAFGPSIEHQLRPHDLTLRHFPQSFGFSTLGGWLATRSGGHFATLYTHIDDLTESLRIVTPVGISESRRLPGSGAGPSPDRLFLGSEGTLGIITEAWMRLQHRPRWQVTVSVVFDDWAAAVAATRTIAQAGLYPANCRLLDPAEALLNAGTSVGGGLLVLAFESADHPIDPWLHRAVAITAEHGGTVTAQRSRGTTSDATEHNAAANWRSAFLRMPYQRDALVRRGVIAETFETACTWDGFDTLHAAVTDAARTAIWKVCGTGVVTCRFTHVYPDGPAPYYGIYAGGRWGSLDAQWDEIKAAVSEAISASGGTITHHHAVGRDHRAWYDRQRPDPFAAALRAAKSALDPAGILNPGVLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR89</accession>
    <name>A0A7U8TR89_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidinol-phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidinol-phosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03758</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol phosphate = L-histidinol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14465"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="3.1.3.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 8/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416388.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR89"/>
    <dbReference type="GeneID" id="45427124"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00013"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004401">
        <property type="term" value="F:histidinol-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011809">
        <property type="entry name" value="His_9_proposed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02067">
        <property type="entry name" value="his_9_HisN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD14860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="260" mass="27709" checksum="6F9C786ABE3C08D9" modified="2021-06-02" version="1">MSHDDLMLALALADRADELTRVRFGALDLRIDTKPDLTPVTDADRAVESDVRQTLGRDRPGDGVLGEEFGGSTTFTGRQWIVDPIDGTKNFVRGVPVWASLIALLEDGVPSVGVVSAPALQRRWWAARGRGAFASVDGARPHRLSVSSVAELHSASLSFSSLSGWARLGLRERFIGLTDTVWRVRAYGDFLSYCLVAEGAVDIAAEPQVSVWDLAALDIVVREAGGRLTSLDGVAGPHGGSAVATNGLLHDEVLTRLNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRC5</accession>
    <name>A0A7U8TRC5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03801</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRC5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="119" mass="13497" checksum="E6E07393EE396E44" modified="2021-06-02" version="1">MRLGAGFRKPVPTLLLEHRSRKSGKNFVAPLLYITDRNNVIVVASALGQAENPQWYRNLPPNPDTHIQIGSDRRPVRAVVASSDERARLWPRPVDAYADFDSCQSWTERGIPVIILRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRF1</accession>
    <name>A0A7U8TRF1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="143" mass="14292" checksum="4B2E142036CEB3D0" modified="2021-06-02" version="1">MPVRAPAAVRGAGLIVAVQGGAALVVAAALLVRGLAGADQHIVNGLGTAGWFVLVGGAVLAAGCRLAVGKLWGRGLAVFAQLLLLPVAWYLIVGSHQPAIGIPVGIIALGVLVLLFSPPSIRWAAGRDQRGAASAANRGPDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRF3</accession>
    <name>A0A7U8TRF3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03869</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRF3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Na_H_Exchanger" evidence="5">
        <location>
            <begin position="13"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="385" mass="39075" checksum="B8685743A78323E0" modified="2021-06-02" version="1">MEVSRALLFELGVLLAVLAVLGAVARRFALSPIPVYLLAGLSLGNGGILGVAAAGEFIATGAPIGVVLLLLALGLEFSATEFASSLRHHLPSAGVDIVLNATPGAVAGWLLGLDGVAILGLAGVTYISSSGVIARLLEDLRRLGNRETPAVLSVLVLEDFAMAAYLPLFAVLATDGSWLEAVVGMTVAIAALLGAFAASYRWGHHVGRLVTHPDSEQLLLRVLGITLIVAAVAESLHASAAVGAFLVGLTLTGETADRARMVLTPLRDLFATIFFLGIGLSVDPGKLVSMLPVALALAAVTAATKVATGMFAARREGVARRGQLRAGTALVARGEFSLIIIGLAGASIPGVAALATAYVFVMAIVGPILARYTGGGLPAAAVASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRF9</accession>
    <name>A0A7U8TRF9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03867</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00554">
        <property type="reaction ID" value="UER00611"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="168"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD14969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="315" mass="33245" checksum="54B43AE32ABDC2C0" modified="2021-06-02" version="1">SPTGRGVHRRFRKTSGSRNGGTTRLLLRAVGDWLVRPGAQLQAVGSAVAGLVTNSGQLVETGRKVLDIARTVARGTAPSSPLNATVSRNRRFTVARASLDDYRTVRARYDCDVHDVVLTVIAGALGNWLMSRGEAVAPTATVRAMAPLSVYADDQLDSTGPGQAISQVTPFLVDLPVGEGNAVVRLSQIAHATESNPTAASLVDARTIVTLSGLAPATLHAMGVRVATSFSARLFNLLITNAPGTQSQMYIAGTKLLETYSVPPLLHNQALAISVTSYNGMLYFGINADRDAMSDVDLLPGLLSQALDELLEASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRI0</accession>
    <name>A0A7U8TRI0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03912</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRI0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="PTHR11814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfate_transp" evidence="13">
        <location>
            <begin position="31"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD15014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="764" mass="80566" checksum="DFD9090EA337D617" modified="2021-06-02" version="1">MTIPRSQHMSTAVNSCTEAPASRSQWMLANLRHDVPASLVVFLVALPLSLGIAIASGAPIIAGVIAAVVGGIVAGAVGGSPVQVSGPAAGLTVVVAELIDELGWPMLCLMTIAAGALQIVFGLSRMARAALAIAPVVVHAMLAGIGITIALQQIHVLLGGTSHSSAWRNIVALPDGILHHELHEVIVGGTVIAILLMWSKLPAKVRIIPGPLVAIAGATVLALLPVLQTERIDLQGNFFDAIGLPKLAEMSPGGQPWSHEISAIALGVLTIALIASVESLLSAVGVDKLHHGPRTDFNREMVGQGSANVVSGLLGGLPITGVIVRSSANVAAGARTRMSTILHGVWILLFASLFTNLVELIPKAALAGLLIVIGAQLVKLAHIKLAWRTGNFVIYAITIVCVVFLNLLEGVAIGLVVAIVFLLVRVVRAPVEVKPVGGEQSKRWRVDIDGTLSFLLLPRLTTVLSKLPEGSEVTLNLNADYIDDSVSEAISDWRRAHETRGGVVAIVETSPAKLHHAHARPPKRHFASDPIGLVPWRSARGKDRGSASVLDRIDEYHRNGAAVLHPHIAGLTDSQDPYELFLTCADSRILPNVITASGPGDLYTVRNLGNLVPTDPDDRSVDAALDFAVNQLGVSSVVVCGHSSCAAMTALLEDDPANTTTPMMRWLENAHDSLVVFRNHHPARRSAESAGYPEADQLSIVNVAVQVERLTRHPILATAVAAADLQVIGIFFDISTARVYEVGPNGIICPDEPADRPVDHESAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRL9</accession>
    <name>A0A7U8TRL9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03940</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="123"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="221" mass="24800" checksum="121760420C1BD3C3" modified="2021-06-02" version="1">MRTVYHQRLTELAGRLGEMCSLAGIAMKRATQALLEADIGAAEQVIRDHERIVAMRAQVEKEAFALLASQHPVAGELREIFSAVQIIADTERMGALAVHIAKITRREYPNQVLPEEVRNCFADMAKVAIALGDSARQVLVNRDPQEAAQLHDRDDAMDDLHRHLLSVLIDREWRHGVRVGVETALLGRFFERFADHAVEVGRRVIFMVTGVLPTEDEISTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRP4</accession>
    <name>A0A7U8TRP4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfurtransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen cyanide + thiosulfate = 2 H(+) + sulfite + thiocyanate</text>
            <dbReference type="Rhea" id="RHEA:16881"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:18022"/>
            <dbReference type="ChEBI" id="CHEBI:18407"/>
            <dbReference type="ChEBI" id="CHEBI:33542"/>
            <dbReference type="EC" id="2.8.1.1"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417149.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRP4"/>
    <dbReference type="GeneID" id="45427279"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00683">
        <property type="entry name" value="RHODANESE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="174"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="297" mass="33320" checksum="5930AB5F9C63A533" modified="2021-06-02" version="1">MPLPADPSPTLSAYAHPERLVTADWLSAHMGAPGLAIVESDEDVLLYDVGHIPGAVKIDWHTDLNDPRVRDYINGEQFAELMDRKGIARDDTVVIYGDKSNWWAAYALWVFTLFGHADVRLLNGGRDLWLAERRETTLDVPTKTCTGYPVVQRNDAPIRAFRDDVLAILGAQPLIDVRSPEEYTGKRTHMPDYPEEGALRAGHIPTAVHIPWGKAADESGRFRSREELERLYDFINPDDQTVVYCRIGERSSHTWFVLTHLLGKADVRNYDGSWTEWGNAVRVPIVAGEEPGVVPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRS4</accession>
    <name>A0A7U8TRS4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative mRNA interferase YoeB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_04043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YoeB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417760.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRS4"/>
    <dbReference type="GeneID" id="45427357"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009614">
        <property type="entry name" value="YoeB_toxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38039">
        <property type="entry name" value="PTHR38039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06769">
        <property type="entry name" value="YoeB_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02116">
        <property type="entry name" value="toxin_Txe_YoeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="85" mass="10102" checksum="8663A289B5FD9DAF" modified="2021-06-02" version="1">MRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLKARYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRT2</accession>
    <name>A0A7U8TRT2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase/methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417461.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRT2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="43"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="243" mass="26641" checksum="BD755CC5AF7DC4D3" modified="2021-06-02" version="1">MTCSRRDMSLSFGSAVGAYERGRPSYPPEAIDWLLPAAARRVLDLGAGTGKLTTRLVERGLDVVAVDPIPEMLDVLRAALPQTVALLGTAEEIPLDDNSVDAVLVAQAWHWVDPARAIPEVARVLRPGGRLGLVWNTRDERLGWVRELGEIIGRDGDPVRDRVTLPEPFTTVQRHQVEWTNYLTPQALIDLVASRSYCITSPAQVRTKTLDRVRQLLATHPALANSNGLALPYVTVCVRATLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRW3</accession>
    <name>A0A7U8TRW3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03975</name>
        <name evidence="2" type="ORF">TBLG_04081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003904310.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="120" mass="13018" checksum="E296E3A86BB0D1FA" modified="2021-06-02" version="1">MPNPVTMLYGRKADLVILPHVLAEERPHPYSTPGRKRGAQIALTTGIDALASFAPQIVNPRHGLSRVVQCLGGCENKRHAYFRSISKTPHIRARGVPSVCAVRTVGVDGAKRPPKPIPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TS04</accession>
    <name>A0A7U8TS04_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-coumarate-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="3">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="349" mass="37237" checksum="7653F2B056295A45" modified="2021-06-02" version="1" fragment="single">MTPTHPTVTELLLPLSEIDDRGVYFEDSFTSWRDHIRHGAAIAAALRERLDPARPPHVGVLLQNTPFFSATLVAGALSGIVPVGLNPVRRGAALAGDIAKADCQLVLTGSGSAEVPADVEHINVDSPEWTDEVAAHRDTEVRFRSADLADLFMLIFTSGTSGDPKAVKCSHRKVAIAGVTITQRFSLGRDDVCYVSMPLFHSNAVLVGWAVAAACQGSMALRRKFSASQFLADVRRYGETYANYVGKSLSYVLATPELPDDAHNPLRAVYGNEGVPGDIDRFGRRFGCVVMDGFGSTEGGVAITRTLDTPAGALGPTAGGESKSSDPRHRRTRAPTGSGRRTWSTPPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TS37</accession>
    <name>A0A7U8TS37_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MCE-associated alanine and valine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418960.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427479"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="242" mass="25611" checksum="B202EDEAC6F3E3EC" modified="2021-06-02" version="1">MAADTGVAGGQQSTTRRARRKASRPAGPAEGESSRPAQGAATVRAAARTESKPAKAAKPALRPVKPPPRRPAHRVLVGWLSLAAGLLAIAALAWGVTALVMQNRDADARQARNQRFVDAATQTVVNMFSYTPDTIDESVNRFVNGTSGPLRGMLNANNNVDNLKGLFRATNATSEAVVNGAALEGIDEISDNASVLVSVRVTVADIDGVNKPSMPYRLRVIVHEDENGRMTGYDLKYPDGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSM7</accession>
    <name>A0A7U8TSM7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TSM7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030941848" evidence="1">
        <location>
            <begin position="26"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="300" mass="33064" checksum="9C7A5C12673D0C8D" modified="2021-06-02" version="1">MNVLSLGSSSGVVWGRVPITAPAGAATGVTSRADAHSQMRRYAQTGPTAKLSSAPMTTMWGAPLHRRWRGSRLRDPRQAKFLTLASLKWVLANRAYTPWYLVRYWRLLRFKLANPHIITRGMVFLGKGVEIHATPELAQLEIGRWVHIGDKNTIRAHEGSLRFGDKVVLGRDNVINTYLDIEIGDSVLMADWCYICDFDHRMDDITLPIKDQGIIKSPVRIGPDTWIGVKVSVLRGTTIGRGCVLGSHAVVRGAIPDYSIAVGAPAKVVKNRQLSWEASAAQRAELAAALADIERKKAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSZ2</accession>
    <name>A0A7U8TSZ2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_03804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899952.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TSZ2"/>
    <dbReference type="GeneID" id="45427169"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD14906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="144" mass="15205" checksum="259C959D5015C767" modified="2021-06-02" version="1">MPLVYFDASAFVKLLTTETGSSLASALWDGCDAALSSRLAYPEVRAALAAAARNHDLTESELADAERDWEDFWAATRPVELTATVEQHAGHLARAHALRGADAVHLASALAVGDPGLVVAVWDRRLHTGAHAAGCRVAPAQLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT05</accession>
    <name>A0A7U8TT05_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PlsC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415914.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT05"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="2">
        <location>
            <begin position="95"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="304" mass="32632" checksum="52E04ED25E8DCF25" modified="2021-06-02" version="1">MSAPAVTEHSWLPRATCGVSCVSVGDAAQVRRPLVVLRVALRVMLALLLVPGVPLVVMPLPGRTRVQRIYCRLVLRLFGVRITVSGSPVRNLRGVLVVSGHVSWLDVFCIGSVLPGSFVARADMFTGRTIGIVARILKIIPIERASLRRLPGVVDTIARRLRAGQTVVAFPEGTTWCGRPGDDAGRPAARAGAGCSHRGCGAFYPAMFQAAIDAGRPVQPLRLTYHHVDGTVSTAPAFVGDDTLVRSVCRLLTVRRTLAWVRVESLQLPGTDRRNLARRCQSAVLAGALGQSGQRPGRRHVPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTF4</accession>
    <name>A0A7U8TTF4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417757.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTF4"/>
    <dbReference type="GeneID" id="45427356"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="91" mass="10194" checksum="5A4140972F329F0A" modified="2021-06-02" version="1">MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSVDELREMAGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTP3</accession>
    <name>A0A7U8TTP3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030941059" evidence="1">
        <location>
            <begin position="28"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="208" mass="22090" checksum="8A2461314DB5E42A" modified="2021-06-02" version="1">MQSRKTTSVLAAALLFCGLLGPGTAPPATGGGPACRPAELFATDNTTDGFELPAVATIALTGTVVTGSTLVDGVFWSNERQQIGYERSREFHLCVVDAPTLHNAAEALHRQFNQEAVLTFDYLPQNAPEADAILITVPDIGIARFRDAFASDLAAHHRLRGGSVTTADHTLILVAGNGDLDVARRLVEEAGGDWNATTIAHGRREFVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTV1</accession>
    <name>A0A7U8TTV1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021888">
        <property type="entry name" value="DUF3499"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12005">
        <property type="entry name" value="DUF3499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="163" mass="16811" checksum="4046C3905963AC32" modified="2021-06-02" version="1">MRVSGASAALVHDSLSVVNVPRRCCRPGCPHYAVATLTFVYSDSTAVIGPLATAREPHSWDLCVGHAGRITAPRGWELVRHAGPLPSHPDEDDLVALADAVREGGPSAGRRHHPGGNGAPLHGFDDFPAAATGAPTGGGVLAPPEPGAGRRRGHLRVLPDPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TU26</accession>
    <name>A0A7U8TU26_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_04001</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="348" mass="38168" checksum="1327809A850A14B3" modified="2021-06-02" version="1">MARPMGKLPSNTRKCAQCAMAEALLEIAGQTINQKDLGRSGRMTRTDNDTWDLASSVGATATMIATARALASRAENPLINDPFAEPLVRAVGIDLFTRLASGELRLEDIGDHATGGRWMIDNIAIRTKFYDDFFGDAATAGIRQVVILAAGLDTRAYRLPWPPGTVVYEIDQPAVIKFKTRALANLNAEPNAERHAVAVDLRNDWPTALKNAGFDPARPTAFSAEGLLSYLPPQGQDRLLDAITALSAPDSRLATQSPLVLDLAEEDEKKMRMKSAAEAWRERGFDLDLTELIYFDQRNDVADYLAGSGWQVTTSTGKELFAAQGLPPFEDDHITRFADRRYISAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y200</accession>
    <name>A0A7U8Y200_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Benzoquinone methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y200"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="66"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="241" mass="25945" checksum="32652F8B609D5170" modified="2021-06-02" version="1">MSTVLTYIRAVDIYEHMTESLDLEFESAYRGESVAFGEGVRPPWSIGEPQPELAALIVQGKFRGDVLDVGCGEAAISLALAERGHTTVGLDLSPAAVELARHEAAKRGLANASFEVADASSFTGYDGRFDTIVDSTLFHSMPVESREGYLQSIVRAAAPGASYFVLVFDRAAIPEGPINAVTEDELRAAVSKYWIIDEIKPARLYARFPAGFAGMPALLDIREEPNGLQSIGGWLLSAHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2C2</accession>
    <name>A0A7U8Y2C2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CE-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="44"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="130"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="269" mass="28971" checksum="47EA74474EA6C5F8" modified="2021-06-02" version="1">MPTLVTRKNRRAWLYVEGVVLLLVGALVLVLVYKQFRGEFTPKTELTMVASRAGLVMEAGSKVTYNGVEIGRVGSISEIERDGRPAAKLVLDVNPRYISLIPVNVVADIEAATLFGNKYVALSAPKIPQQQRISSHDVIDVGSVTTEFNTLFETITSIAEKVDPIELNATLSAVAQALDGLGGKFGESIVNGNQILAQLNPRLPQLGYDVRRLADLGEVYVDASPDLWSFLQNALTTARTLTSQQRDLDAALLAATGAGAGCGRFGRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2C5</accession>
    <name>A0A7U8Y2C5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein lpqO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011094">
        <property type="entry name" value="Uncharacterised_LppY/LpqO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07485">
        <property type="entry name" value="DUF1529"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030958239" evidence="2">
        <location>
            <begin position="25"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="316" mass="32897" checksum="1DB0CFE5F4FE78F8" modified="2021-06-02" version="1">MIRRRGARMAALLAAAALALTACAGSDDKGEPDDGGDRGASLATTSDADWKPVADILGRTGKLNDGSVYKIGFARSDLSVQTKGVTVAPALSLGSWVAFARTPDGQTMLMGDLVVTEDELASVTDAVQAGGLQQTALHKHLLEQSPPIWWTHIAGHGDAADLARAVRSALDATDTPPPAPATSGQTSLDLDTAAIDEALGRSGTIAGGVYKFFIARRDPVTMSGMLIPPSMGLATALNFQPTGNGRAAINGDFVMTAAEVQDVVQALRGGGIDIVAIHNHGFDEQPRLFYMHFWAENDAVALARTLRAAVDATAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2F2</accession>
    <name>A0A7U8Y2F2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08666">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAF" evidence="1">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="218" mass="22567" checksum="965D8E4291251EA7" modified="2021-06-02" version="1">MAESSLNPSLVSRISAFLRPDWTRTVRARRFAAAGLVMLAGVAALRSNPEDDRAEVVVAAHDLRPGTALTPGDVRLEKRSATTLPDGSQADLDAVVGSTLASPTRRGEVLTDVRLLGSRLAESTAGPDARIVPLHLADSALVDLVRVGDVVDVLAAPVTDSPAALRLLATDAIVVLVSAQQKAQAADSDRVVLVALPARLANTVAGAALGQTVTLTLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2H0</accession>
    <name>A0A7U8Y2H0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">L-fuculose phosphate aldolase fucA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403695.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2H0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="9"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="218" mass="23110" checksum="F23DA761ADB9DAD0" modified="2021-06-02" version="1">MNFVDDPESAVLAAAKDMLRRGLVEGTAGNISARRSDGNVVITPSSVDYAEMLLHDLVLVDAGGAVLHAKDGRSPSTELNLHLACYRAFDDIGSVIHSHPVWATMFAVAHEPIPACIDEFAIYCGGDVRCTEYAASGTPEVGRNAVRALEGRAAALIANHGLVAVGPRPDQVLRVTALVERTAQIVWGARALGGPVPIPEDVCRNFTGVYGYLRANPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2H4</accession>
    <name>A0A7U8Y2H4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405722.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2H4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="283" mass="32043" checksum="AD486BEFDCAF8116" modified="2021-06-02" version="1">MGAQPFIGSEALAAGLISWHELGKYYTAIMPNVYLDKRLKPSLRQRVIAAWLWSGRKGVIAGASASALHGAKWVDDHALVELIWRNARAPNGVRTKDELLLDGEVQRLCGLTVTTVERTAFDLGRRPPLGQAITRLDALANATDFKINDVRELARKHPHTRGLRQLDKALDLVDPGAQSPKETWLRLLLINAGFPRPSTQIPLLGVYGHPKYFLDMGWEDIMLAVEYDGEQHRLSRDQFVKDVERLEYIRRAGWTHIRVLADHKGPDVVRRVRQAWDTLTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2I3</accession>
    <name>A0A7U8Y2I3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">1,4-dihydroxy-2-naphthoate octaprenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901663">
        <property type="term" value="P:quinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd13962">
        <property type="entry name" value="PT_UbiA_UBIAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026046">
        <property type="entry name" value="UBIAD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13929">
        <property type="entry name" value="PTHR13929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="222" mass="22526" checksum="50B710B53C77E5B1" modified="2021-06-02" version="1">RQGGSGAVGGLAAGDPALGADRCHDEPGARCAGRAGLALLSAPWLIAVGAICIAGAWLYTGGSKPYGYAGFGELAVFVFFGPVAVLGTQYTQALRVDWVGLAQAVATGALSCSVLVANNLRDIPTDARADKITLAVRLGDARTRMLYQGLLAVAGVLTFVLMLATPWCVVGLVAAPLALRAAGPVRSGRGGRELIPVLRDTGLAMLVWALAVAGALAFGQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2J7</accession>
    <name>A0A7U8Y2J7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="74" mass="7250" checksum="10CC403C7114D8C1" modified="2021-06-02" version="1">MAVTVGLAEPAARAGPAVFALAASGPETAAQGRLAVTAEPAGTGGDSWQRRVTGAAGALGVKRWCKVAPVAHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2P4</accession>
    <name>A0A7U8Y2P4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">moaA</name>
        <name evidence="14" type="ORF">TBLG_03021</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404564.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2P4"/>
    <dbReference type="GeneID" id="45424835"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="33"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="292"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="360" mass="38986" checksum="894E5490A60A65BC" modified="2021-06-02" version="1">MTLTALGMPALRSRTNGIADPRVVPTTGPLVDTFGRVANDLRVSLTDRCNLRCSYCMPERGLRWLPGEQLLRPDELARLIHIAVTRLGVTSVRFTGGEPLLAHHLDEVVAATARLRPRPEISLTTNGVGLARRAGALAEAGLDRVNVSLDSIDRAHFAAITRRDRLAHVLAGLAAAKAAGLTPVKVNAVLDPTTGREDVVDLLRFCLERGYQLRVIEQMPLDAGHSWRRNIALSADDVLAALRPHFRLRPDPAPRGSAPAELWLVDAGPNTPRGRFGVIASVSHAFCSTCDRTRLTADGQIRSCLFSTEETDLRRLLRGGADDDAIEAAWRAAMWSKPAGHGINAPDFIQPDRPMSAIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2P7</accession>
    <name>A0A7U8Y2P7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycogen phosphorylase</fullName>
            <ecNumber evidence="4">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3417" evidence="11">
        <location>
            <begin position="13"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="863" mass="95531" checksum="E3805ED03D5B255D" modified="2021-06-02" version="1">MKALRRFTVRAHLPERLAALDQLSTNLRWSWDKPTQDLFAAIDPALWEQCGHDPVALLGAVNPARLDELALDAEFLGALDELAADLNDYLSRPLWYQEQQDAGVAAQALPTGIAYFSLEFGVAEVLPNYSGGLGILAGDHLKSASDLGVPLIAVGLYYRSGYFRQSLTADGWQHETYPSLDPQGLPLRLLTDANGDPVLVEVALGDNAVLRARIWVAQVGRVPLLLLDSDIPENEHDLRNVTDRLYGGDQEHRIKQEILAGIGGVRAIRAYTAVEKLTPPEVFHMNEGHAGFLGIERIRELVTDAGLDFDTALTVVRSSTVFTTHTPVPAGIDRFPLEMVQRYVNDQRGDGRSRLLPGLPADRIVALGAEDDPAKFNMAHMGLRLAQRANGVSLLHGRVSRAMFNELWAGFDPDEVPIGSVTNGVHAPTWAAPQWLQLGRELAGSDSLREPVVWQRLHQVDPAHLWWIRSQLRSMLVEDVRARLRQSWLERGATDAELGWIATAFDPNVLTVGFARRVPTYKRLTLMLRDPDRLEQLLLDEQRPIQLIVAGKSHPADDGGKALIQQVVRFADRPQVRHRIAFLPNYDMSMARLLYWGCDVWLNNPLRPLEACGTSGMKSALNGGLNLSIRDGWWDEWYDGENGWEIPSADGVADENRRDDLEAGALYDLLAQAVAPKFYERDERGVPQRWVEMVRHTLQTLGPKVLASRMVRDYVEHYYAPAAQSFRRTAGAQFDAARELADYRRRAEEAWPKIEIADVDSTGLPDTPLLGSQLTLTATVRLAGLRPNDVTVQGVLGRVDSGDVLMDPVTVEMAHTGTGDGGYEIFSTTTPLPLAGPVGYTVRVLPRHPMLAASNELGLVTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2R0</accession>
    <name>A0A7U8Y2R0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407185.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2R0"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012328">
        <property type="entry name" value="Chalcone/stilbene_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001099">
        <property type="entry name" value="Chalcone/stilbene_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011141">
        <property type="entry name" value="Polyketide_synthase_type-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11877">
        <property type="entry name" value="PTHR11877"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02797">
        <property type="entry name" value="Chal_sti_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00195">
        <property type="entry name" value="Chal_sti_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000451">
        <property type="entry name" value="PKS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chal_sti_synt_N" evidence="8">
        <location>
            <begin position="33"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Chal_sti_synt_C" evidence="9">
        <location>
            <begin position="251"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000451-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="393" mass="42032" checksum="317D24C33B9CFD42" modified="2021-06-02" version="1">MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2V6</accession>
    <name>A0A7U8Y2V6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="11"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="230" mass="25347" checksum="50CFCB8F6DECFAAD" modified="2021-06-02" version="1">MRFSYAEAMTDFTFYIPLAKAAEAAGYSSMTIPDSIAYPFESDSKYPYTPDGNREFMDGKPFIETFVLTAALGAVTTRLRFNFFVLKLPIRPPALVAKQAGSLAALIGNRVGLGVGTSPWPEDYELMGVPFAKRGKRIDECIEIVRGLTTGDYFEFHGEFYDIPKTKMTPAPTQPIPILVGGHADAALRRAARADGWMHGGGDPDELDRLIARVKRLREEAGKTSPFEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2W6</accession>
    <name>A0A7U8Y2W6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Metal cation transporter P-type ATPase CtpV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="371" mass="38403" checksum="9553C87B8FF4AC6E" modified="2021-06-02" version="1">MSIAPATRSPAVFSTGTDSPVSIDSSTAARRAVCLLDQSHNLRQRGVCPDGGGAHDTVVFDKTGTLTRARMRVTDVIAGQRRQPNQVLRLAAAVESGSEHPIGAAIVAAAHERGLAIPAANAFTAVAGHGVRAQVNGGPVVVGRRKLVDEQHLVLPDHLAAAAVEQEERGRTAVFVGQDGQVVGVLAVADTVKDDAADVVGRLHAMGLQVAMITGDNARTAAAIAKQVGIEKVLAEVLPQDKVAEVRRLQDQGRVVAMVGDGVNDAPALVQADLGIAIGTGTDVAIEASDITLMSGRLDGVVRAIELSRQTLRTIYQNLGWAFGYNTAAIPLAALGALNPVVAGAAMGFSSVSVVTNSLRLRRFGRDGRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y305</accession>
    <name>A0A7U8Y305_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="215" mass="22107" checksum="48B363E71E6C9F3B" modified="2021-06-02" version="1">MPGQPAPSRGESLWAHAEGSISEDVILAGARERATDIGAGAVTPAVGALLCLLAKLSGGKAVAEVGTGAGVSGLWLLSGMRDDGVLTTIDIEPEHLRLARQAFAEAGIGPSRTRLISGRAQEVLTRLADASYDLVFIDADPIDQPDYVAEGVRLLRSGGVIVVHRAALGGRAGDPGARDAEVIAVREAARLIAEDERLTPALVPLGDGVLAAVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y320</accession>
    <name>A0A7U8Y320_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405919.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y320"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031061393" evidence="3">
        <location>
            <begin position="29"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="PPE" evidence="4">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="618" mass="60207" checksum="021E3275747595A3" modified="2021-06-02" version="1">MSFLVLPPEVNSALMFAGAGSGPTLAAAAAWDGLAAELGQAANSFSSATAALADTAWQGPAATAMAAAAAPYASWLSTAATRALSAAAQAKAAAAVYEAARAATVDPLLVAANRHQLVSLVLSNLFGQNAPAIAATEAAYEQLWAADVAAMVSYHSGASAVAAQLAPWAQAVRALPNPTAPALASGPAALAIPALGIGNTGIGNIFSIGNIGDYNLGNGNTGNANLGSGNTGQANLGSGNTGFFNFGSGNTANTNFGSGNLGNLNLGSGNDGNGNFGLGNIGDGNRGSGNVGSFNFGTANAGSFNVGSANHGSPNVGFANLGNNNLGIANLGNNNLGIANLGNNNIGIGLTGDNMIGIGALNSGIGNLGFGNSGNNNIGLFNSGNNNIGFFNSGDSNFGFFNSGDTNTGFGNAGFTNTGFGNAGSGNFGFGNAGNNNFGFGNSGFENMGVGNSGAYNTGSFNSGTLNTGDLNSGDFNTGWANSGDINTGGFHSGDLNTGFGSPVDQPVMNSGFGNIGTGNSGFNNSGDANSGFQNTNTGAFFIGHSGLLNSGGGQHVGISNSGTGFNTGLFNTGFNNTGIGNSATNAAFTTTSGVANSGDNSSGGFNAGNDQSGFFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y366</accession>
    <name>A0A7U8Y366_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein lprH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407343.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030700475" evidence="1">
        <location>
            <begin position="27"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="228" mass="24288" checksum="3C069DD0EB00498A" modified="2021-06-02" version="1">MACLGRPGCRGWAGASLVLVVVLALAACTESVAGRAMRATDRSSGLPTSAKPARARDLLLQDGDRAPFGQVTQSRVGDSYFTSAVPPECSAALLFKGSPLRPDGSSDHAEAAYNVTGPLPYAESVDVYTNVLNVHDVVWNGFRDVSHCRGDAVGVSRAGRSTPMRLRYFATLSDGVLVWTMSNPRWTCDYGLAVVPHAVLVLSACGFKPGFPMAEWASKRRAQLDSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4D5</accession>
    <name>A0A7U8Y4D5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_02814</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403423.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4D5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041504">
        <property type="entry name" value="AidB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18158">
        <property type="entry name" value="AidB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AidB_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="176"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="280"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="542" mass="58534" checksum="1AD435206E6E2C33" modified="2021-06-02" version="1">MSDTHVVTNQVPPLENYNPASSPVLIEALIQEGGQWGLDEVNEVGAISASCQAQRWGELADRNRPILHTHDAYGYRVDEVEYDPAYHELMRTAITHGMHAAPWADDRPGAHVVRAAKTSVWTVEPGHICPISMTYAVVPALRYNSELAAVYEPLLTSREYDPELKPATTKAGITAGMSMTEKQGGSDVRAGTTQATPNADGSYSLTGHKWFTSAPMCDIFLVLAQAPDGLSCFLLPRVLPDGTRNRMFLQRLKDKLGNHANASSEVEYDGAVAWLVGEEGRGVPTIIEMVNLTRLDCALGSATSMRTGLTRAVHHAQHRKAFGAYLIDQPLMRNVLADLAVEAEAATIVAMRMAGATDNAVRGNETEALLRRIGLAAAKYWVCKRSTAHAAEALECLGGNGYVEDSGMPRLYREAPLMGIWEGSGNVSALDTLRAMATRPACVEVLFDELARSAGQDPRLDGHVERLRPQLGDLDTIGYRARKIAEDICLALQGSLLVRHGHPAVAEAFLATRLGGQWGGAYGTMPAGLDLAPILERALVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4I2</accession>
    <name>A0A7U8Y4I2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="10" type="ORF">TBLG_02949</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404114.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4I2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001587">
        <property type="entry name" value="FGAM_synthase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="9">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="212"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="7">
        <location>
            <begin position="470"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="8">
        <location>
            <begin position="588"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="324"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="552"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="754" mass="79507" checksum="AFDB14694FDA5E6D" modified="2021-06-02" version="1">MLDTVEHAATTPDQPQPYGELGLKDDEYRRIRQILGRRPTDTELAMYSVMWSEHCSYKSSKVHLRYFGETTSDEMRAAMLAGIGENAGVVDIGDGWAVTFKVESHNHPSYVEPYQGAATGVGGIVRDIMAMGARPVAVMDQLRFGAADAPDTRRVLDGVVRGIGGYGNSLGLPNIGGETVFDPCYAGNPLVNALCVGVLRQEDLHLAFASGAGNKIILFGARTGLDGIGGVSVLASDTFDAEGSRKKLPSVQVGDPFMEKVLIECCLELYAGGLVIGIQDLGGAGLSCATSELASAGDGGMTIQLDSVPLRAKEMTPAEVLCSESQERMCAVVSPKNVDAFLAVCRKWEVLATVIGEVTDGDRLQITWHGETVVDVPPRTVAHEGPVYQRPVARPDTQDALNADRSAKLSRPVTGDELRATLLALLGSPHLCSRAFITEQYDRYVRGNTVLAEHADGGMLRIDESTGRGIAVSTDASGRYTLLDPYAGAQLALAEAYRNVAVTGATPVAVTNCLNFGSPEDPGVMWQFTQAVRGLADGCADLGIPVTGGNVSFYNQTGSAAILPTPVVGVLGVIDDVRRRIPTGLGAEPGETLMLLGDTRDEFDGSVWAQVTADHLGGLPPVVDLAREKLLAAVLSSASRDGLVSAAHDLSEGGLAQAIVESALAGETGCRIVLPEGADPFVLLFSESAGRVLVAVPRTEESRFRGMCEARGLPAVRIGVVDQGSDAVEVQGLFAVSLAELRATSEAVLPRYFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4N0</accession>
    <name>A0A7U8Y4N0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADPH dependent 2,4-dienoyl-CoA reductase fadH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03352</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="8"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="378"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="674" mass="72885" checksum="99A69178A68A4644" modified="2021-06-02" version="1">MTNPYPNLLSPLDLGFTTLRNRVVMGSMHTGLEDRARHIDRLADYFAERARGGVGLIITGGYAPNRTGWLLPFASELVTSAQARRHRRITRAVHDSGAKILLQILHAGRYAYHPLAVSASPIKAPITPFRPRALSARGVEATIADFARCAQLARDAGYDGVEIMGSEGYLLNQFLAPRTNKRTDSWGGTPANRRRFPVEIIRRSRAAVGSDFIICYRLSMADYVAEGQSWDEIVALATEVEGAGATIINSGFGWHEARVPTIVTSVPGGAFVDISSAVAEHVTIPVVASNRINMPQAAERILAETQVRLISMARPMLSDPDWVLKAQSNRVDEINTCISCNQACLDHAFARKTVSCLLNPRAGRETQLVLSPTRRARSVAVVGAGPAGLATAANAAQRGHRVTLFEANDFIGGQFDMARRIPGKEEFSETIRYFSTILAKHGVEVRLGTRVAAQELTGYDEVVLATGVAPRIPAIPGIDHPMVLTYAEAITGVRPVGRTVAVVGAGGIGFDVTELLVTDSSPTLNLKEWKAEWGVADPREARGALTTPLPAPPAREVYLLQRTKGPQGKRLGKTTGWVHRASLKAKGVHQLSGVNYEQINDDGLHISFGPKRRRPQLLAVDNVVVCAGQEPVRDLESELRRHGINPHIIGGAAVAAELDAKRAIKQGTELAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4N2</accession>
    <name>A0A7U8Y4N2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha/beta fold family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="222" mass="23677" checksum="5C33522CA64EB3A1" modified="2021-06-02" version="1">MAFADDLRTIADTLGIDKMAVVGLSGGGPYTLACAAGLPDRVVAAGVLGGVAPTRGPDAISGGLMRLGSAVAPLLQVGGTPLRLGASLLIRAARPVASPALDLYGLLSPRADRHLLARPEFKAMFLDDLLNGSRKQLAAPFADVIAFARDWGFRLDEVKVPVRWWHGDHDHIVPFSHGEHVVSRLPDAKLLHLPGESHLAGLGRGEEILSTLMQIWDRDLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4S4</accession>
    <name>A0A7U8Y4S4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit c</fullName>
            <shortName evidence="13">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpE</name>
        <name evidence="15" type="ORF">TBLG_03487</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
            <topology evidence="13">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406686.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4S4"/>
    <dbReference type="GeneID" id="64235844"/>
    <dbReference type="GeneID" id="66596952"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 13" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="14">
        <location>
            <begin position="11"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="13">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD12903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="81" mass="8055" checksum="36303496CDDF52CC" modified="2021-06-02" version="1">MDPTIAAGALIGGGLIMAGGAIGAGIGDGVAGNALISGVARQPEAQGRLFTPFFITVGLVEAAYFINLAFMALFVFATPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4V1</accession>
    <name>A0A7U8Y4V1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Respiratory nitrate reductase subunit delta narJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4V1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="201" mass="21918" checksum="9D37566625BE02AF" modified="2021-06-02" version="1">MWQSASLLLAYPDDGLAERLHMVDALRAHQTGPAAALLGRTVAELRALAPMAAAAQYVETFDMRRRSTMYLTYWTAGDTRNRGREMLAFATAYRDAGVKPPRTEAPDYLPVVLEFAATVDPEAGRRLLTEHRVPIDVLRGALADAKSPYEYTVAAICETLPAATNQEVRRAQRLAQSGPPAEAVGLQPFTLTVPPKRAEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7E2</accession>
    <name>A0A7U8Y7E2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MoaD family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899918.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7E2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="PTHR33359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="83" mass="9188" checksum="6EE1751F2A36810C" modified="2021-06-02" version="1">MIKVNVLYFGAVREACDETPREEVEVQNGTDVGNLVDQLQQKYPRLRDHCQRVQMAVNQFIAPLSTVLGDGDEVAFIPQVAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7M5</accession>
    <name>A0A7U8Y7M5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Squalene synthase HpnD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carotenoid biosynthesis; phytoene biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417954.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7M5"/>
    <dbReference type="GeneID" id="45427393"/>
    <dbReference type="UniPathway" id="UPA00799"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:farnesyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016767">
        <property type="term" value="F:geranylgeranyl-diphosphate geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017828">
        <property type="entry name" value="SQ_synth_HpnD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03465">
        <property type="entry name" value="HpnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="302" mass="33142" checksum="C214605A7B93AFFD" modified="2021-06-02" version="1">MTEIEQAYRITESITRTAARNFYYGIRLLPREKRAALSAVYALGRRIDDVADGELAPETKITELDAIRKSLDNIDDSSDPVLVALADAARRFPVPIAMFAELIDGARMEIDWTGCRDFDELIVYCRRGAGTIGKLCLSIFGPVSTATSRYAEQLGIALQQTNILRDVREDFLNGRIYLPRDELDRLGVRLRLDDTGALDDPDGRLAALLRFSADRAADWYSLGLRLIPHLDRRSAACCAAMSGIYRRQLALIRASPAVVYDRRISLSGLKKAQVAAAALASSVTCGPAHGPLPADLGSHPSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7N3</accession>
    <name>A0A7U8Y7N3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PPOX class F420-dependent enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7N3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019966">
        <property type="entry name" value="F420-dep_enz_PPOX_Rv3369"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03667">
        <property type="entry name" value="Rv3369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="144" mass="15718" checksum="9102BB4111B376DF" modified="2021-06-02" version="1">MWAGYRWAMSVELTQEVSARLTSDLYGWLTTVARSGQPVPRLVWFYFDGTDLTVYSMPQAAKVAHITAHPQVSLNLDSDGNGAGIIVVGGTAAVVATDVDCRDDAPYWAKYREDAAKFGLTEAIAAYSTRLKITPTRVWTTPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y813</accession>
    <name>A0A7U8Y813_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin--[biotin carboxyl-carrier protein] ligase</fullName>
            <ecNumber evidence="2">6.3.4.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EC" id="6.3.4.15" evidence="2"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="BPL_C" evidence="3">
        <location>
            <begin position="218"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="266" mass="28151" checksum="F261DF001AC39247" modified="2021-06-02" version="1">MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHSRGWAATARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y821</accession>
    <name>A0A7U8Y821_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 11">2.4.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">UMP pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">UPRTase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">upp</name>
        <name evidence="12" type="ORF">TBLG_03948</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Allosterically activated by GTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UPRTase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="3 11"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417245.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y821"/>
    <dbReference type="GeneID" id="45427304"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00636"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006223">
        <property type="term" value="P:uracil salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01218_B">
        <property type="entry name" value="Upp_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034332">
        <property type="entry name" value="Upp_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005765">
        <property type="entry name" value="Ura_phspho_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01091">
        <property type="entry name" value="upp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="5-phospho-alpha-D-ribose 1-diphosphate binding" evidence="11">
        <location>
            <begin position="129"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uracil binding" evidence="11">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>uracil</name>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD15050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="207" mass="21898" checksum="63B2486AE7C42AF8" modified="2021-06-02" version="1">MQVHVVDHPLAAARLTTLRDERTDNAGFRAALRELTLLLIYEATRDAPCEPVPIRTPLAETVGSRLTKPPLLVPVLRAGLGMVDEAHAALPEAHVGFVGVARDEQTHQPVPYLDSLPDDLTDVPVMVLDPMVATGGSMTHTLGLLISRGAADITVLCVVAAPEGIAALQKAAPNVRLFTAAIDEGLNEVAYIVPGLGDAGDRQFGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y826</accession>
    <name>A0A7U8Y826_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417288.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y826"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="51"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="204" mass="21615" checksum="13C5CB74C9C4B07F" modified="2021-06-02" version="1">MSVQTDPALREHPNRVDWNARYERAGSAHAPFAPVPWLADVLRAGVPDGPVLELASGRSGTALALAAHGRQVTAIDVSDVALLQLDSEAVRRGVADRLNLVQADLGCWEPGETRFALVLSRLFWDAAIFHRACEAVMPGGVLAWESLALSGAEAGTASAKRRVKPGEPACLLPADFTVVHEGQGNCDSAPSRIMIARRSPLPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y832</accession>
    <name>A0A7U8Y832_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03841</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416873.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y832"/>
    <dbReference type="GeneID" id="45427203"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="231" mass="25121" checksum="DE604D5E1C0C20BA" modified="2021-06-02" version="1">MPSPSSADQVADSPRPRLPADHPGVNELFALLAYGEVAAFYRLTDEARMAPDLRGRISMASMAAAEMGHYELLRNALERRGVDVVSAMSKYTSALENYHRLTTPSTWLEALVKTYVADALAADLYLEIADGLPDEVADVVRAALSETGHSQFVVAEVRAAVTASGKQRSRLALWSRRLLGEAITQAQLVLADHDELVDLVVSGSGGLSQLGAFFDRLQQTHDQRMRELGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y8A1</accession>
    <name>A0A7U8Y8A1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y8A1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="2">
        <location>
            <begin position="2"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="246" mass="26630" checksum="B2704E034DFD2981" modified="2021-06-02" version="1">MAIDPAAAYASAIRTPGLLPNAKLVVDHFHVTTLANDALTAVRRRVTWAFHDRRGRKIDPQWANRRRLLTARERLSDKSFAKMRNRINAVDPRAQILSAWIAKEELRTLLSTVRTGGDPHLARHHLHRFLPGASTRRSPNCSPWPPPLTSHPRSTPSWSPASPTRASVVGEVAEMLGDIDGQCVQVEVPVPERGPAGCGGLDGLGRAGVSATPRVCAAMTAVNVAGRCAGQQADVGPTPQHRCRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y8C4</accession>
    <name>A0A7U8Y8C4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetolactate synthase</fullName>
            <ecNumber evidence="6">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_04122</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="6"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900704.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y8C4"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="12">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="10">
        <location>
            <begin position="198"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="11">
        <location>
            <begin position="391"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD15228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="552" mass="57257" checksum="5A6CE9C099652D9D" modified="2021-06-02" version="1">MTVGDHLVARMRAAGISVVCGLPTSRLDSLLVRLSRDAGFQIVLARHEGGAGYLADGFARASGKSAAVFVAGPGATNVISAVANASVNQVPMLILTGEVAVGEFGLHSQQDTSDDGLGLGATFRRFCRCSVSIESIANARSKIDSAFRALASIPRGPVHIALPRDLVDERLPAHQLGTAAAGLGGLRTLAPCGPDVADEVIGRLDRSRAPMLVLGNGCRLDGIGEQIVAFCEKAGLPFATTPNGRGIVAETHPLSLGVLGIFGDGRADEYLFDTPCDLLIAVGVSFGGLVTRSFSPRWRGLKADVVHVDPDPSAVGRFVATSLGITTSGRAFVNALNCGRPPRFCRRVGVRPPAPAALPGTPQARGESIHPLELMHELDRELAPNATICADVGTCISWTFRGIPVRRPGRFFATVDFSPMGCGIAGAIGVALARPEEHVICIAGDGAFLMHGTEISTAVAHGIRVTWAVLNDGQMSASAGPVSGRMDPSPVARIGANDLAAMARALGAEGIRVDTRCELRAGVQKALAATGPCVLDIAIDPEINKPDIGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9Y8</accession>
    <name>A0A7U8Y9Y8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Two component system transcriptional regulator devR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03754</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416369.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y9Y8"/>
    <dbReference type="GeneID" id="45427119"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="217" mass="23294" checksum="1BA535C26CC4EB51" modified="2021-06-02" version="1">MVKVFLVDDHEVVRRGLVDLLGADPELDVVGEAGSVAEAMARVPAARPDVAVLDVRLPDGNGIELCRDLLSRMPDLRCLILTSYTSDEAMLDAILAGASGYVVKDIKGMELARAVKDVGAGRSLLDNRAAAALMAKLRGAAEKQDPLSGLTDQERTLLGLLSEGLTNKQIADRMFLAEKTVKNYVSRLLAKLGMERRTQAAVFATELKRSRPPGDGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA33</accession>
    <name>A0A7U8YA33_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD-capped RNA hydrolase NudC</fullName>
            <shortName evidence="7">DeNADding enzyme NudC</shortName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">NADH pyrophosphatase</fullName>
            <ecNumber evidence="7">3.6.1.22</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nudC</name>
        <name evidence="9" type="ORF">TBLG_03827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11800"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide</text>
            <dbReference type="Rhea" id="RHEA:48868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90832"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.6.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end NAD(+)-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60876"/>
            <dbReference type="Rhea" id="RHEA-COMP:15698"/>
            <dbReference type="Rhea" id="RHEA-COMP:15719"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:144029"/>
            <dbReference type="ChEBI" id="CHEBI:144051"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Nudix hydrolase family. NudC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EC" id="3.6.1.22" evidence="7"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA33"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00297">
        <property type="entry name" value="Nudix_NudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022925">
        <property type="entry name" value="RNA_Hydrolase_NudC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="168"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="236"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nudix box" evidence="7">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD14929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="313" mass="33795" checksum="38484E252EDABD02" modified="2021-06-02" version="1">MTNVSGVDFQLRSVPLLSRVGADRADRLRTDMEAAAAGWPGAALLRVDSRNRVLVANGRVLLGAAIELADKPPPEAVFLGRVEGGRHVWAVRAALQPIADPDIPAEAVDLRGLGRIMDDTSSQLVSSASALLNWHDNARFSALDGAPTKPARAGWSRVNPITGHEEFPRIDPAVICLVHDGADRAVLARQAAWPERMFSLLAGFVEAGESFEVCVAREIREEIGLTVRDVRYLGSQPWPFPRSLMVGFHALGDPDEEFSFSDGEIAEAAWFTRDEVRAALAAGDWSSASESKLLLPGSISIARVIIESWAACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA61</accession>
    <name>A0A7U8YA61_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">S30AE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031538845" evidence="2">
        <location>
            <begin position="40"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="192" mass="20929" checksum="CD2863D09B70F259" modified="2021-06-02" version="1">MSRSPTTSASTFRRNSPAWSGSTGPSTCSTSNSTTNVIAASASPVSAWRSPRVARAGGASEACADSFYAALESAVVKLESRLRRGKDRRKVHYGDKTPVSLAEATAVVPAPENGFNTRPAEAHDHDGAVVEREPGRIVRTKEHPAKPMSVDDALYQMELVGHDFFLFYDKDTERPSVVYRRHAYDYGLIRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA97</accession>
    <name>A0A7U8YA97_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418034.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA97"/>
    <dbReference type="GeneID" id="45427416"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="158" mass="17389" checksum="080C08100AE63C93" modified="2021-06-02" version="1">MTADTEPVTIGALTRADAQRCAELEAQLFVGDDPWPPAAFNRELASPHNHYVGARSGGTLVGYAGISRLGRTPPFEYEVHTIGVDPAYQGRGIGRRLLRELLDFARGGVVYLEVRTDNDAALALYRSVGFQRVGLRRRYYRVSGADAYTMRRDSGDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF67</accession>
    <name>A0A7U8TF67_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_02727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403122.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF67"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="130" mass="14112" checksum="7B38EAE492156816" modified="2021-06-02" version="1">MNVRRALADTSVFIGIEATRFDPDRFAGYEWGVSVVTLGELRLGVLQASGPEAAARRLSTYQLAQRFEPLGIDEAVSEAWALLVSKLRAAKLRVPINDSWIAATAVAHGIAILTQDNDYAAMPDVEVITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF68</accession>
    <name>A0A7U8TF68_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein mce2F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02726</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403119.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="40"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="122"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="516" mass="54194" checksum="F37F03477F86E77D" modified="2021-06-02" version="1">MLTRAIKTQLVLLTVLAVIAVVVLGWYFLRIPSLVGIGRYTLYAELPRSGGLYRTANVTYRGITIGKVTGVEPTERGARATMSIDNGYQIPTDASANVHSVSAVGEQFVDLVSTRTSGPYLRHGQTITTTTVPSQIGPALDAANRGLAVLPKDRVASVLHEASEAVGGLGSSLNRLIEATQAIAHDVRGSLEDIDDIIERSAPIIDSQVNSGNEIARWAANLNTLAAQTAQTDPAVRSILANAAPTADQVNATFSDVRESLPQTLANLEVVIDMLKRYHNGVEQALVFLPQSGAIAQSVTTEFPGQAGLGVGGLALNQPPPCLTGFLPASEWRSPADTSTAPLPKGTYCRIPMDASNVVRGARNNPCVDVPGKRAATPRECRSNEAYVPGGTNPWYGDPNQMLSCPAPAARCDQPVKPGQVIPAPSVNNGINPLPADQLPGTPPPVNDPLQRPGSGTVQCNGQQPNPCVYTPSTFPTTIYDVQSGKVVAPDGVVYSVEASTHAGADGWKVMLAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF77</accession>
    <name>A0A7U8TF77_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="10" type="ORF">TBLG_02730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403137.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF77"/>
    <dbReference type="GeneID" id="45424566"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030986198" description="Ribonuclease VapC" evidence="8">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PINc" evidence="9">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="137" mass="14818" checksum="12975B4555CA4402" modified="2021-06-02" version="1">MKPPLAVDTSVAIPLLVRTHTAHAAVVAWWAHREAALCGHALAETYSVLTRLPRDLRLAPMDAARLLTERFAAPLLLSSRTTEHLPRVLAQFEITGGAVYDALVALAAAEHRAELATRDARAKDTYEKIGVHVVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFB7</accession>
    <name>A0A7U8TFB7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898549.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="57" mass="5849" checksum="62858455BD7D0F2E" modified="2021-06-02" version="1">MTPRTDEGAAAPCLMPDVTMPVKRGDARGALGVGPALFVVSVSSSLVRARSCRCTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFB8</accession>
    <name>A0A7U8TFB8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_02800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403386.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFB8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="2"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="145" mass="15245" checksum="DB4804BF6738FC3D" modified="2021-06-02" version="1">MIVLDTTVLVYAKGAEHPLRDPCRDLVAAIADERIAATTTAEVIQEFVHVRARRRDRSDAAALGRVTMPNCSRRYSPSIEATSKRGLTLFETTPGLEACDAVLAAVAASAGATALVSADPAFADLSDVVHVIPDAAGMVSLLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFC7</accession>
    <name>A0A7U8TFC7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403442.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFC7"/>
    <dbReference type="GeneID" id="45424640"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="165" mass="18379" checksum="AD3C974B4DFCDF8A" modified="2021-06-02" version="1">MSVNDGVDQMGAEPDIMEFVEQMGGYFESRSLTRLAGRLLGWLLVCDPERQSSEELATALAASSGGISTNARMLIQFGFIERLAVAGDRRTYFRLRPNAFAAGERERIRAMAELQDLADVGLRALGDAPPQRSRRLREMRDLLAYMENVVSDALGRYSQRTGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFE7</accession>
    <name>A0A7U8TFE7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplD</name>
        <name evidence="7" type="ORF">TBLG_02846</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="5">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403580.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFE7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="223" mass="23743" checksum="E9AF8F30E35A66AB" modified="2021-06-02" version="1">MAAQEQKTLKIDVKTPAGKVDGAIELPAELFDVPANIALMHQVVTAQRAAARQGTHSTKTRGEVSGGGRKPYRQKGTGRARQGSTRAPQFTGGGVVHGPKPRDYSQRTPKKMIAAALRGALSDRARNGRIHAITELVEGQNPSTKSARAFLASLTERKQVLVVIGRSDEAGAKSVRNLPGVHILAPDQLNTYDVLRADDVVFSVEALNAYIAANTTTSEEVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFF6</accession>
    <name>A0A7U8TFF6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5 7">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplP</name>
        <name evidence="10" type="ORF">TBLG_02852</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403592.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFF6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="9">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="138" mass="15692" checksum="2C878FC597C69D0C" modified="2021-06-02" version="1">MLIPRKVKHRKQHHPRQRGIASGGTTVNFGDYGIQALEHAYVTNRQIESARIAINRHIKRGGKVWINIFPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRVLFELSYPNEGVARAALTRAIHKLPIKARIITREEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFK4</accession>
    <name>A0A7U8TFK4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplB</name>
        <name evidence="9" type="ORF">TBLG_02848</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403582.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFK4"/>
    <dbReference type="GeneID" id="45424669"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="8">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="225"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="280" mass="30577" checksum="456837947E32FFBB" modified="2021-06-02" version="1">MAIRKYKPTTPGRRGASVSDFAEITRSTPEKSLVRPLHGRGGRNAHGRITTRHKGGGHKRAYRMIDFRRNDKDGVNAKVAHIEYDPNRTARIALLHYLDGEKRYIIAPNGLSQGDVVESGANADIKPGNNLPLRNIPAGTLIHAVELRPGGGAKLARSAGSSIQLLGKEASYASLRMPSGEIRRVDVRCRATVGEVGNAEQANINWGKAGRMRWKGKRPSVRGVVMNPVDHPHGGGEGKTSGGRHPVSPWGKPEGRTRNANKSSNKFIVRRRRTGKKHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFK8</accession>
    <name>A0A7U8TFK8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="199" mass="22486" checksum="FB91563E9EAEF4D5" modified="2021-06-02" version="1">MSRRAIHSGRAAPRRSGNSHLVLRNRVPSSKDSPRRRPHHEFMTESIGEPLSTNLIERYLRARGRRYFRGHHDAEFFFVANAHLRLHVHLEISPAYRDVFTIRVSPAYFFPATDHTRLAEIVNAWNLQNHEVTAIVHGSSDPHRIGVAAERSLIRDRIRFDDFATFVDNAVSAATELFGQLTAAGLPPTATPPLLRDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFL8</accession>
    <name>A0A7U8TFL8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">UDP-glucose-4-epimerase cpsY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_02952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the stealth family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898594.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFL8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031358">
        <property type="entry name" value="Stealth_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021520">
        <property type="entry name" value="Stealth_CR2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031357">
        <property type="entry name" value="Stealth_CR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031356">
        <property type="entry name" value="Stealth_CR4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17101">
        <property type="entry name" value="Stealth_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11380">
        <property type="entry name" value="Stealth_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17102">
        <property type="entry name" value="Stealth_CR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17103">
        <property type="entry name" value="Stealth_CR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0270">Exopolysaccharide synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Stealth_CR1" evidence="5">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR2" evidence="4">
        <location>
            <begin position="239"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR3" evidence="6">
        <location>
            <begin position="389"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="Stealth_CR4" evidence="7">
        <location>
            <begin position="465"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="532" mass="60268" checksum="248451CB250C27F5" modified="2021-06-02" version="1">MPKISSRDGGRPAQRTVNPIIVTRRGKIARLESGLTPQEAQIEDLVFLRKVLNRADIPYLLIRNHKNRPVLAINIELRAGLERALAAACATEPMYAKTIDEPGLSPVLVATDGLSQLVDPRVVRLYRRRIAPGGFRYGPAFGVELQFWVYEETVIRCPVENSLSRKVLPRNEITPTNVKLYGYKWPTLDGMFAPHASDVVFDIDMVFSWVDGSDPEFRARRMAQMSQYVVGEGDDAEARIRQIDELKYALRSVNMFAPWIRRIFIATDSTPPPWLAEHPKITIVRAEDHFSDRSALPTYNSHAVESQLHHIPGLSEHFLYSNDDMFFGRPLKASMFFSPGGVTRFIEAKTRIGLGANNPARSGFENAARVNRQLLFDRFGQVITRHLEHTAVPLRKSVLIEMEREFPEEFARTAASPFRSDTDISVTNSFYHYYALMTGRAVPQEKAKVLYVDTTSYAGLRLLPKLRKHRGYDFFCLNDGSFPEVPAAQRAERVVSFLERYFPIPAPWEKIAADVSRRDFAVPRTSAPSEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFR1</accession>
    <name>A0A7U8TFR1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="337"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="425" mass="45884" checksum="992CAE441E3B1CAA" modified="2021-06-02" version="1">MPSYGNLGRLGGRHEYGVLVAMTSSAELDRVRWAHQLRSYRIASVLRIGVVGLMVAAMVVGTSRSEWPQQIVLIGVYAVAALWALLLAYSASRRFFALRRFRSMVRLEPFAFTAVDVLILTGFQLLSTDGIYPLLIMILLPVLVGLDVSTRRAAVVLACTLVGFAVAVLGDPVMLRAIGWPETIFRFALYAFLCATALMVVRIEERHTRSVAGLSALREELLAQTMTASEVLQRRIAEAIHDGPLQDVLAARQELIELDAVTPGDERVGRALAGLQSASERLRQATFELHPAVLEQVGLGPAVKQLAASTAQRSGIKISTDIDYPIRSGIDPIVFGVVRELLSNVVRHSGATTASVRLGITDEKCVLDVADDGVGVTGDTMARRLGEGHIGLASHRARVDAAGGVLVFLATPRGTHVCVELPLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFU2</accession>
    <name>A0A7U8TFU2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404651.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFU2"/>
    <dbReference type="GeneID" id="45424855"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="495" mass="55039" checksum="08CB55F48674DB44" modified="2021-06-02" version="1">MTGRCPTVAVVGAGMSGMCVAITLLSAGITDVCIYEKADDVGGTWRDNTYPGLTCDVPSRLYQYSFAKNPNWTQMFSRGGEIQDYLRGIAERYGLRHRIRFGATVVSARFDDGRWVLRTDSGTESTVDFLISATGVLHHPRIPPIAGLDDFRGTVFHSARWDHTVPLLGRRIAVIGTGSTGVQLVCGLAGVAGKVTMFQRTAQWVLPWPNPRYSKLARVFHRAFPCLGSLAYKAYSLSFETFAVALSNPGLHRKLVGAVCRASLRRVRDPRLRRALTPDYEPMCKRLVMSGGFYRAIQRDDVELVTAGIDHVEHRGIVTDDGVLHEVDVIVLATGFDSHAFFRPMQLTGRDGIRIDDVWQDGPHAHQTVAIPGFPNFFMMLGPHSPVGNFPLTAVAESQAEHIVQWIKRWRHGEFDTMEPKSAATEAYNTVLRAAMPNTVWTTGCDSWYLNKDGIPEVWPFAPAKHRAMLANLHPEEYDLRRYAAVRATSRPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFU4</accession>
    <name>A0A7U8TFU4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrate/nitrite response transcriptional regulator narL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02996</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404388.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFU4"/>
    <dbReference type="GeneID" id="45424810"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="148"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="216" mass="22916" checksum="4604E6D7C8D132E5" modified="2021-06-02" version="1">MSNPQPEKVRVVVGDDHPLFREGVVRALSLSGSVNVVGEADDGAAALELIKAHLPDVALLDYRMPGMDGAQVAAAVRSYELPTRVLLISAHDEPAIVYQALQQGAAGFLLKDSTRTEIVKAVLDCAKGRDVVAPSLVGGLAGEIRQRAAPVAPVLSAREREVLNRIACGQSIPAIAAELYVAPSTVKTHVQRLYEKLGVSDRAAAVAEAMRQRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFW2</accession>
    <name>A0A7U8TFW2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404747.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFW2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022171">
        <property type="entry name" value="PPE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12484">
        <property type="entry name" value="PPE-SVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="3">
        <location>
            <begin position="6"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-SVP" evidence="4">
        <location>
            <begin position="319"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="383"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="423" mass="41440" checksum="370DB0745C4978A3" modified="2021-06-02" version="1">MDFGLLPPEVNSSRMYSGPGPESMLAAAAAWDGVAAELTSAAVSYGSVVSTLIVEPWMGPAAAAMAAAATPYVGWLAATAALAKETATQARAAAEAFGTAFAMTVPPSLVAANRSRLMSLVAANILGQNSAAIAATQAEYAEMWAQDAAVMYSYEGASAAASALPPFTPPVQGTGPAGPAAAAAATQAAGAGAVADAQATLAQLPPGILSDILSALAANADPLTSGLLGIASTLNPQVGSAQPIVIPTPIGELDVIALYIASIATGSIALAITNTARPWHIGLYGNAGGLGPTQGHPLSSATDEPEPHWGPFGGAAPVSAGVGHAALVGALSVPHSWTTAAPEIQLAVQATPTFSSSAGADPTALNGMPAGLLSGMALASLAARGTTGGGGTRSGTSTDGQEDGRKPPVVVIREQPPPGNPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFX3</accession>
    <name>A0A7U8TFX3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03085</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404769.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFX3"/>
    <dbReference type="GeneID" id="45424893"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="263" mass="26746" checksum="544AB32F709D97E3" modified="2021-06-02" version="1">MILDMFRLDDKVAVITGGGRGLGAAIALAFAQAGADVLIASRTSSELDAVAEQIRAAGRRAHTVAADLAHPEVTAQLAGQAVGAFGKLDIVVNNVGGTMPNTLLSTSTKDLADAFAFNVGTAHALTVAAVPLMLEHSGGGSVINISSTMGRLAARGFAAYGTAKAALAHYTRLAALDLCPRVRVNAIAPGSILTSALEVVAANDELRAPMEQATPLRRLGDPVDIAAAAVYLASPAGSFLTGKTLEVDGGLTFPNLDLPIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFY2</accession>
    <name>A0A7U8TFY2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formamidopyrimidine-DNA glycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404828.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFY2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FPG-type" evidence="5">
        <location>
            <begin position="109"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="158" mass="16495" checksum="6BA9BF572AF38E52" modified="2021-06-02" version="1">MAGTPQPRALGPDALDVSTDDLAGLLAGNTGRIKTVITDQKVIAGIGNAYSDEILHVAKISPFATAGKLSGAQLTCLHEAMASVLSDAVRRSVGQGAAMLKGEKRSGLRVHARTGLPCPVCGDTVREVSFADKSFQYCPTCQTGGKALADRRMSRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFY6</accession>
    <name>A0A7U8TFY6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901948.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFY6"/>
    <dbReference type="GeneID" id="45424908"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="92" mass="9737" checksum="F0732A4A607D47C6" modified="2021-06-02" version="1">MGRSATIAMVPKRRDAMNRHSGPILSSGFIASSSNSCPANSLRMPSALAAETLSFDDRAVRRSTHHPGGGYPQKHAINLQSGLCPAYANASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG08</accession>
    <name>A0A7U8TG08_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VWFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="395"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="586" mass="64627" checksum="E08A43FF2A82A525" modified="2021-06-02" version="1">TAADGSCCAATLRWHLAGDQEAARRGRAGRTQGAARALDDDARFAELQLDALPASPAKAVQELAEYRWRSGQAREKYEQIKDLLGRELLDQRFAGMKQALAGATDDDRRRVTEMLDDLNDLLDKHARGEDTQRDFDEFMTKHGEFFPENPRNVEELLDSLAKRAAAAQRFRNSLSQEQRDELDALAQQAFGSPALMRALDRLDAHLQAARPGEDWTGSQQFSGDNPFGMGEGTQALADIAELEQLAEQLSQSYPGASMDDVDLDALARQLGDQAAVGARTLAELERALVNQGFLDRGSDGQWRLSPKAMRRLGETALRDVAQQLSGRHGERDHRRAGAAGELTGATRPWQFGDTEPWHVARTLTNAVLRQAAAVHDRIRITVEDVEVAETETRTQAAVALLVDTSFSMVMENRWLPMKRTALALHHLVCTRFRSDALQIIAFGRYARTVTAAELTGLAGVYEQGTNLHHALALAGRHLRRHAGAQPVVLVVTDGEPTAHLEDFDGDGTSVFFDYPPHPRTIAHTVRGFDDMARLGAQVTIFRLGSDPGLARFIDQVARRVQGRVVVPDLDGLGAAVVGDYLRFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG11</accession>
    <name>A0A7U8TG11_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898667.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG11"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="239"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="388" mass="41515" checksum="7F9DAF7778B75B15" modified="2021-06-02" version="1">MTDTSFIESEERQALRKAVASWVANYGHEYYLDKARKHEHTSELWAEAGKLGFLGVNLPEEYGGGGAGMYELSLVMEEMAAAGSALLLMVVSPAINGTIIAKFGTDDQKKRWLPGIADGSLTMAFAITEPDAGSNSHKITTTARRDGSDWIIKGQKVFISGIDQAQAVLVVGRSEEAKTGKLRPALFVVPTDAPGFSYTPIEMELVSPERQFQVFLDDVRLPADALVGAEDAAIAQLFAGLNPERIMGAASAVGMGRFALGRAVDYVKTRKVWSTPIGAHQGLAHPLAQCHIEVELAKLMTQKAATLYDHGDDFGAAEAANMAKYAAAEASSRAVDQAVQSMGGNGLTKEYGVAAMMTSARLARIAPISREMVLNFVAQTSLGLPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG19</accession>
    <name>A0A7U8TG19_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Adhesion component transport transmembrane protein ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03150</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="769"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="820"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="8">
        <location>
            <begin position="28"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="290"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="7">
        <location>
            <begin position="755"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="855" mass="93571" checksum="2379EFE906F24841" modified="2021-06-02" version="1">MNDQAPVAYAPLWRTAWRRLRQRPFQYILLVLGIALGVAMIVAIDVSSNSAQRAFDLSAAAITGKSTHRLVSGPAGVDQQLYVDLRRHGYDFSAPVIEGYVLARGLGNRAMQFMGTDPFAESAFRSPLWSNQNIAELGGFLTRPNGVVLSRQVAQKYGLAVGDRIALQVKGAPTTVTLVGLLTPADEVSNQKLSDLIIADTSTAQELSHMPGRLSHIDLIIKDEDTATRIHQRLTAGVRMETSDTQRDTVKQMTDAFTVNLTALSLIALLVGIFLIYNTVTFNVVQRRPFFAILRCLGVTREQLFWLIMTESLVAGLIGTGLGLLIGIWLGEGLIGLVTQTINDFYFVINVRNVSVSAESLLKGLIIGIFAAMLATLPPAIEAMRTVPASTLRRSSLESKITKLMPWLWVAWFGLGSFGVLMLWLPGNNLVVAFVGLFSVLIALALIAPPLTRFVMLRLAPGLGRLLGPIGRMAPRNIVRSLSRTSIAIAALMMAVSLMVGVSISVGSFRQTLANWLEVTLKSDVYVSPPTLTSGRPSGNLPVDAVRNISKWPGVRDAVMARYSSVFAPDWGREVELMAVSGDISDGKRPYRWIDGNKDTLWPRFLAGKGVMLSEPMVSRQHLQMPPRPITLMTDSGPQTFPVLAVFSDYTSDQGVILMDRASYRAHWQDDDVTTMFLFLASGANSGALIDQLQAAFVGREDIVIQSTHSVREASMVIFDRSFTITIALQLVATVVAFIGVLSALMSLELDRAHELGVFRAIGMTTRQLWKLMFIETGLMGGMAGLMALPTGCILAWILVRIINVRSFGWTLQMHFESAHFLRALLVAVVAALAAGMYPAWRLGRMTIRTAIREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG42</accession>
    <name>A0A7U8TG42_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5642 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG42"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041313">
        <property type="entry name" value="DUF5642"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18702">
        <property type="entry name" value="DUF5642"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5642" evidence="1">
        <location>
            <begin position="63"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="252" mass="25970" checksum="7C06468D4D19CE9C" modified="2021-06-02" version="1">MRPPLAPQFAADLLVKTVSTLRSSGAALGRLTTMRKAVLAVGSVCWLVGCSSGASSTTASTGDIAKVAEVKSGFGPEYTVTDVTPRAIDPGFFSARKLPDGLSFDPANCAQVAAGPQLPTGLQGNMAAVSAEGNGNRFVVIAVETSQPLPAPSPGKDCSKVTFSGTQLRGGIEVVDVPHIDGTQTLGVHRVLQAVVGGSARTGELYDYSARFGDYQVIVIANPLVIPGRPVARVDTQRARDLLVQAVAAVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG44</accession>
    <name>A0A7U8TG44_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mfd</name>
        <name evidence="12" type="ORF">TBLG_03184</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="663"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="842"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1207"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1234" mass="132938" checksum="639351386C4B361B" modified="2021-06-02" version="1">MTAPGPACSDTPIAGLVELALSAPTFQQLMQRAGGRPDELTLIAPASARLLVASALARQGPLLVVTATGREADDLAAELRGVFGDTVALLPSWETLPHERLSPGVDTVGTRLMALRRLAHPDDAQLGPPLGVVVTSVRSLLQPMTPQLGMMEPLTLTVGDESPFDGVVARLVELAYTRVDMVGRRGEFAVRGGILDIFAPTAEHPVRVEFWGDEITEMRMFSVADQRSIPEIDIHTLVAFACRELLLSEDVRARAAQLAARHPAAESTVTGSASDMLAKLAEGIAVDGMEAVLPVLWSDGHALLTDQLPDGTPVLVCDPEKVRTRAADLIRTGREFLEASWSVAALGTAENQAPVDVEQLGGSGFVELDQVRAAAARTGHPWWTLSQLSDESAIELDVRAAPSARGHQRDIDEIFAMLRAHIATGGYAALVAPGTGTAHRVVERLSESDTPAGMLDPGQAPKPGVVGVLQGPLRDGVIIPGANLVVITETDLTGSRVSAAEGKRLAAKRRNIVDPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASAKRGGGAKNTDKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARRAVREIAGELVSLYAKRQASPGHAFSPDTPWQAELEDAFGFTETVDQLTAIEEVKADMEKPIPMDRVICGDVGYGKTEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLQTFGERMSGFPVTIKGLSRFTDAAESRAVIDGLADGSVDIVIGTHRLLQTGVRWKDLGLVVVDEEQRFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQIAAALRRELLRDGQAFYVHNRVSSIDAAAARVRELVPEARVVVAHGQMPEDLLETTVQRFWNREHDILVCTTIVETGLDISNANTLIVERADTFGLSQLHQLRGRVGRSRERGYAYFLYPPQVPLTETAYDRLATIAQNNELGAGMAVALKDLEIRGAGNVLGIEQSGHVAGVGFDLYVRLVGEALETYRDAYRAAADGQTVRTAEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDREVAAVVDELTDRYGALPEPARRLAAVARLRLLCRGSGITDVTAASAATVRLSPLTLPDSAQVRLKRMYPGAHYRATTATVQVPIPRAGGLGAPRIRDVELVQMVADLITALAGKPRQHIGITNPSPPGEDGRGRNTTIKERQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG54</accession>
    <name>A0A7U8TG54_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="565"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="786" mass="84516" checksum="873B2170BED3AB80" modified="2021-06-02" version="1">MLEGIEMIPPRYVEYRGARFPELDVEAVLRRHPQVVLVDELAHTNTPGSKNPKRWQDVQEILDAGITVISTVNIQHLEGLNDVVEQITGIEQKEKIPDEIVRAADQVELVDITPEALRRRLAHGNVYAAERVDAALSNYFRTGNLTALREIALLWLADQVDAALEKYRADKKITATWEARERVVVAVTGGPESETLVRRASRIASKSSAELMVVHVIRGDGLAGVSAPQLGRVRELATSLGATMHTVVGDDVPTALLDFAREMNATQLVVGTSRRSRWARLFDEGIGARTVQESGGIDVHMVTHPAASRASGWSRVSPRERHIASWLAALVVPSVICAITVAWLDRFMGIGGESALFFIGVLIVALLGGVAPAALSALLSGMLLNYFLTEPRYTWTIAEPDAAVTEFVLLAMAVAVAVLVDGAASRTREARRASQEAELLALFAGSVLRGADLATLLQRVRETYSQRAVTMLRVRQGASTGETVACVGTNPCRDVDSADTAIEVGDDEFWMLMAGRKLAARDRRVLTAVATQAAGLVKQRELAEEAGQAEAIARADELRRSLLSAVSHDLRTPLAAAKVAVSSLRTEDVAFSPEDTAELLATIEESIDQLTALVANLLDSSRLAAGVIRPQLRRAYLEEAVQRALVSIGKGATGFYRSGIDRVKVDVGDAVAMADAGLLERVLANLIDNALRYAPDCVVRVNAGRVRERVLINVIDEGPGVPRGTEEQLFAPFQRPGDHDNTTGVGLGMSVARGFVEAMGGTISATDTPGGGLTVVIDLAAPEDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG56</accession>
    <name>A0A7U8TG56_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03206</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405370.1">
        <property type="nucleotide sequence ID" value="NZ_KK338665.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG56"/>
    <dbReference type="GeneID" id="45425011"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022171">
        <property type="entry name" value="PPE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12484">
        <property type="entry name" value="PPE-SVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031080286" evidence="1">
        <location>
            <begin position="33"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-SVP" evidence="3">
        <location>
            <begin position="192"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="275" mass="26225" checksum="C3BA1804F8435392" modified="2021-06-02" version="1">MSFLKTVPEELTAAAAQLGTIGAAMAAQNAAAAAPTTAIAPAALDEVSALQAALFTAYGTFYQQVSAEAQAMHDMFVNTLGISAGTYGVTESLNSSAAASPLSGITGEASAIIQATTGLFPPELSGGIGNILNIGAGNWASATSTLIGLAGGGLLPAEEAAEAASALGGEAALGELGALGAAEAALGEAGIAAGLGSASAIGMLSVPPAWAGQATLVSTTSTLPGAGWTAAAPQAAAGTFIPGMPGVASAARNSAGFGAPRYGVKPIVMPKPATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG80</accession>
    <name>A0A7U8TG80_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405744.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425054"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025443">
        <property type="entry name" value="DUF4307"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14155">
        <property type="entry name" value="DUF4307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="144" mass="15385" checksum="9DC51214A2866A40" modified="2021-06-02" version="1">MTHTPIPRPDARYGRPRLSRRARRRVAIALGVLVAAAGIVIAVIGYQRISTSAVTGSLVGYRLVDDETASVTISVTRSDPSRPVACIVRVRATNGSETGRRELLVPPSEATTVQVTTTVKSSQPPVMADVYGCGTEVPSYLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG98</accession>
    <name>A0A7U8TG98_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="5">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="5">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">xseA</name>
        <name evidence="9" type="ORF">TBLG_03281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="5"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405846.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG98"/>
    <dbReference type="GeneID" id="45425082"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_anti_2" evidence="8">
        <location>
            <begin position="12"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Exonuc_VII_L" evidence="7">
        <location>
            <begin position="128"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="415" mass="44628" checksum="2182DA0BD1E278B4" modified="2021-06-02" version="1">MTQNSAENPFPVRAVAIRVAGWIDKLGAVWVEGQLAQITMRPDAKTVFMVLRDPAADMSLTVTCSRDLVLSAPVKLAEGVQVVVCGKPSFYTGRGTFSLRLSEIRAVGIGELLARIDRLRRLLDAEGLFDPRLKRPIPYLPNMIGLITGRASAAERDVTTVASARWPAARFAVRNVAVQGPNAVGQIVEALRELDRDPDVDVIVLARGGGSVEDLLPFSDETLCRAIAACRTPVVSAVGHEPDNPLCDLVVDLRAATPTDAAKKVVPDTAAEQRLIDDLRRRSAQALRNWVSREQRAVAQLRSRPVLADPMTMVSVRAEEVHRARSTLRRNLTLMVAAETERIGHLAARLATLGPAATLARGYAIVQTVAQTGPEGGSEPQVLRSVHDAPEGTKLRVRVADGALAAVSEGQTNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGA2</accession>
    <name>A0A7U8TGA2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="3">
        <location>
            <begin position="47"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="291" mass="31123" checksum="40EC5F0F7C7BAF5E" modified="2021-06-02" version="1">MPKRPDNQTWRYWRTVTGVVVAGAVLVVGGLSGRVTRAENLSCSVIKCVALTFDDGPGPYTDRLLHILTDNDAKATFFLIGNKVAANPAGARRIADAGMEIGSHTWEHPNMTTIPPEDIPGQFSRANDVIAAATGRTPTLYRPAGGLSNDAVRQAAAKVGQAEILWDVIPFDWINDSNTAATRHMLMTQIKPGSVVLFHDTYSSTVDVVYQFIPVLKANGYRLVTVSELLGPRAPGSSYGSRENGPPINELRDIPASEIPPLPNTSSPKPMPNFPITDIAGQNSGGPNNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGB2</accession>
    <name>A0A7U8TGB2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ychF</name>
        <name evidence="7" type="ORF">TBLG_03285</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898732.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGB2"/>
    <dbReference type="GeneID" id="45425086"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="272"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="357" mass="38097" checksum="C70A5951D18114D3" modified="2021-06-02" version="1">MSLSLGIVGLPNVGKSTLFNALTRNNVVAANYPFATIEPNEGVVSLPDPRLDKLAELFGSQRVVPAPVTFVDIAGLVKGASEGAGLGNKFLAHIRECDAICQVVRVFVDDDVTHVTGRVDPQSDIEVVETELILADLQTLERATGRLEKEARTNKARKPVYDAALRAQQVLDAGKTLFAAGVDAAALRELNLLTTKPFLYVFNADEAVLTDPARVGELRALVAPADAVFLDAAIESELTELDDESAAELLESIGQSERGLDALARAGFHTLKLQTFLTAGPKEARAWTIHQGDTAPKAAGVIHSDFEKGFIKAEIVSYDDLVAAGSMAAAKAAGKVRIEGKDYVMADGDVVEFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGC6</accession>
    <name>A0A7U8TGC6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Alpha-methylacyl-CoA racemase mcr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898740.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGC6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="360" mass="38685" checksum="52633107358AC843" modified="2021-06-02" version="1">MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSVDGISRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVTERLGLGPEECAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHAIGRGDERPVPPLNLVGDFGGGSMFLLVGILAALWERQSSGKGQVVDAAMVDGSSVLIQMMWAMRATGMWTDTRGANMLDGGAPYYDTYECADGRYVAVGAIEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFASHDRDHWGAVFANSDACVTPVLAFGEVHNEPHIIERNTFYEANGGWQPMPAPRFSRTASSQPRPPAATIDIEAVLTDWDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGG8</accession>
    <name>A0A7U8TGG8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03392</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406252.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="224" mass="24862" checksum="846E5824A202A95C" modified="2021-06-02" version="1">MHIGLKIFIWGVLGLVVFGALLFGPAGTFDYWQAWVFLAAFVSTTIGPTIYLARNDPAALQRRMRSGPLAEGRTIQKFIVIGAFLGFFAMMVLSACDHRYGWSSVPAAVCVIGDVLVMTGLGIAMLVVIQNRYAASTVRVEAGQILASDGLYKIVRHPMYAGNVVMMTGIPLALGSYWAMFILVPGTLVLVFRILDEEKLLTQELSGYREYRQLVRYRLVPYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGH3</accession>
    <name>A0A7U8TGH3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sec-independent protein translocase protein TatB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tatB</name>
        <name evidence="10" type="ORF">TBLG_03400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TatB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGH3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00237">
        <property type="entry name" value="TatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01410">
        <property type="entry name" value="tatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="131" mass="13985" checksum="D9AA3A6D773D8AB6" modified="2021-06-02" version="1">MFANIGWGEMLVLVMVGLVVLGPERLPGAIRWAASALRQARDYLSGVTSQLREDIGPEFDDLRGHLGELQKLRGMTPRAALTKHLLDGDDSLFTGDFDRPTPKKPDAAGSAGPDATEQIGAGPIPFDSDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGI9</accession>
    <name>A0A7U8TGI9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406264.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="177" mass="19388" checksum="32A42967EC442912" modified="2021-06-02" version="1">MDHARNVPSATGPQRNHLALAEPAHRPSSQAPVMWALSASLGWILPVIAQLVWWAVHPQPPWPHLAAAALTAVAMVVHIGVVPLWRYRVHRWEISPQAVFTRTGWLVQERRITPISRVQTVDTYRGPMDRLFGLANVTVTTASSAGAVHIEALDTDVADRVVAQLTDIAALRGEDAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGJ0</accession>
    <name>A0A7U8TGJ0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898789.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGJ0"/>
    <dbReference type="GeneID" id="45425216"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="97" mass="11064" checksum="706298CC2CAB3434" modified="2021-06-02" version="1">MSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEIIHIARRSASYRMNPCRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGM8</accession>
    <name>A0A7U8TGM8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="5">RF MTase</shortName>
            <ecNumber evidence="5">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prmC</name>
        <name evidence="8" type="ORF">TBLG_03482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="5"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406673.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425274"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="7">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_25" evidence="6">
        <location>
            <begin position="134"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="209"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="325" mass="34536" checksum="8587B145D68F8140" modified="2021-06-02" version="1">MTSAPATMRWGNLPLAGESGTMTLRQAIDLAAALLAEAGVDSARCDAEQLAAHLAGTDRGRLPLFEPPGDEFFGRYRDIVTARARRVPLQHLIGTVSFGPVVLHVGPGVFVPRPETEAILAWATAQSLPARPLIVDACTGSGALAVALAQHRANLGLKARIIGIDDSDCALDYARRNAAGTPVELVRADVTTPCLLPELDGQVDLMVSNPPYIPDAAVLEPEVAQHDPHHALFGGPDGMTVISAVVGLAGRWLRPGGLFAVEHDDTTSSSTVDLVSSTKLFVDVQARKDLAGRPRFVTAMRWGHLPLAGENGAIDPRQRRCRAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGN6</accession>
    <name>A0A7U8TGN6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_02714</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403047.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGN6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="135" mass="14503" checksum="E41EEBD26C0D28E9" modified="2021-06-02" version="1">MIIDTSALLAYFDAAEPDHAAVSECIDSSADALVVSPYVVAELDYLVATRVGVDAELAVLRELAGGAWELANCGAAEIEQAARIVTKYQDQRIGIADAANVVLADRYRTRTILTLDRRHFSALRPIGGGRFTVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGV0</accession>
    <name>A0A7U8TGV0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM86 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012506">
        <property type="entry name" value="YhhN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31885">
        <property type="entry name" value="PTHR31885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07947">
        <property type="entry name" value="YhhN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD13005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="200" mass="21257" checksum="2A367E97EA6EEF86" modified="2021-06-02" version="1">MLQPAFKASMAVLLAAAAVAHPIGRERRWLVPALLLSATGDWLLAIPWWTWAFVFGLGAFLLAHLCFIGALLPLARQAAPSRGRVAAVVAMCVASAGLLVWFWPHLGKDNLTIPVTVYIVALSAMVCTALLARLPTIWTAVGAVCFAASDSMIGIGRFILGNEALAVPIWWSYAAAEILITAGFFFGREVPDNAAAPTDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGW1</accession>
    <name>A0A7U8TGW1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Triosephosphate isomerase</fullName>
            <shortName evidence="3">TIM</shortName>
            <shortName evidence="3">TPI</shortName>
            <ecNumber evidence="3 4">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tpiA</name>
        <name evidence="5" type="ORF">TBLG_03626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="3 4"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407398.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGW1"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="3 4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD13042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="261" mass="27403" checksum="3559BAA35031E471" modified="2021-06-02" version="1">MSRKPLIAGNWKMNLNHYEAIALVQKIAFSLPDKYYDRVDVAVIPPFTDLRSVQTLVDGDKLRLTYGAQDLSPHDSGAYTGDVSGAFLAKLGCSYVVVGHSERRTYHNEDDALVAAKAATALKHGLTPIVCIGEHLDVREAGNHVAHNIEQLRGSLAGLLAEQIGSVVIAYEPVWAIGTGRVASAADAQEVCAAIRKELASLASPRIADTVRVLYGGSVNAKNVGDIVAQDDVDGGLVGGASLDGEHFATLAAIAAGGPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGW4</accession>
    <name>A0A7U8TGW4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03557</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900326.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="PTHR19353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="SSF55856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="489" mass="55124" checksum="55D11239781CB565" modified="2021-06-02" version="1">MTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWISKHPGGAFFIGRTKNRDITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPAFLFKDDFNSWRDTPKYRFDDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVGYFAVQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNYVALSLVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMAIRIVDVFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQFVATLWVSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVIGNRYVDCFLSAGLSSHRVHHVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDRLPRLCRKYLLTPSRQAKERHWGFVREHCSPAALKASASYVVAGFVGIGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGX7</accession>
    <name>A0A7U8TGX7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase lipH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="84"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="319" mass="33878" checksum="EA5CC23ADD021589" modified="2021-06-02" version="1">MTEPTAARPDIDPVLKMLLDTFPVTFTAADGVEVARARLRQLKTPPELLPELRIEERTVGYDGLTDIPVRVYWPPVVRDNLPVVVYYHGGGWSLGGLDTHDPVARAHAVGAQAIVVSVDYRLAPEHPYPAGIDDSWAALRWVGENAAELGGDPSRIAVAGDSAGGNISAVMAQLARDVGGPPLVFQLLWYPTTMADLSLPSFTENADAPILDRDVIDAFLAWYVPGLDISDHTMLPTTLAPGNADLSGLPPAFIGTAEHDPLRDDGACYAELLTAAGVSVELSNEPTMVHGYVNFALVVPAAAEATGRGLAALKRALHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH26</accession>
    <name>A0A7U8TH26_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02909</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403890.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH26"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="68" mass="7681" checksum="A5A3944B0EB889A5" modified="2021-06-02" version="1">MGYRVEADRDLCQGHAMCELEAPEYFRVPKRGQVEILDPEPPEEARGVIKHAVWACPTQALSIRETGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH42</accession>
    <name>A0A7U8TH42_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403164.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH42"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030672248" evidence="1">
        <location>
            <begin position="29"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="103" mass="10182" checksum="3BD1F38BEB1E7C51" modified="2021-06-02" version="1">MNRIVQFGVSAVAAAAIGIGAGSGIAAAFDGEDEVTGPDADRARAAAVQAVPGGTAGEVETETGEGAAAYGVLVTRPDGTRVEVHLDRDFRVLDTEPADGDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THG9</accession>
    <name>A0A7U8THG9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance membrane efflux protein emrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_02930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403977.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THG9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="438"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="44"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="540" mass="56587" checksum="C24BF33DEE8D01E7" modified="2021-06-02" version="1">MLGNAMVEACPAEGDAPVPITPAGRPRSGQRSYPDRLDVGLLRTAGVCVLASVMAHVDVTVVSVAQRTFVADFGSTQAVVAWTMTGYMLALATVIPTAGWAADRFGTRRLFMGSVLAFTLGSLLCAVAPNILLLIIFRVVQGFGGGMLTPVSFAILAREAGPKRLGRVMAVVGIPMLLGPVGGPILGGWLIGAYGWRWIFLVNLPVGLSALVLAAIVFPRDRPAASENFDYMGLLLLSPGLATFLFGVSSSPARGTMADRHVLIPAITGLALIAAFVAHSWYRTEHPLIDMRLFQNRAVAQANMTMTVLSLGLFGSFLLLPSYLQQVLHQSPMQSGVHIIPQGLGAMLAMPIAGAMMDRRGPAKIVLVGIMLIAAGLGTFAFGVARQADYLPILPTGLAIMGMGMGCSMMPLSGAAVQTLAPHQIARGSTLISVNQQVGGSIGTALMSVLLTYQFNHSEIIATAKKVALTPESGAGRGAAVDPSSLPRQTNFAAQLLHDLSHAYAVVFVIATALVVSTLIPAAFLPKQQASHRRAPLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THV6</accession>
    <name>A0A7U8THV6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406104.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THV6"/>
    <dbReference type="GeneID" id="45425139"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="17"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="201" mass="21962" checksum="BEBDB86681B446F8" modified="2021-06-02" version="1">MTVSAPAKANPYRRRGEVLERALYDATLAELESAGYGGLTMEGIAARAQTGKAALYRRWAGKRELVLAAVQYALPPVPEPRADRSARENLLAVFTANCEILAGKTALPSMEIVSQLLHEPELRAIFINSVWAPRLRIVESILQAGVRSGEIDPATLTPMTARIGPALIHQHVLFTGSPPDREQLTRIIDAMILTTGERRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THW7</accession>
    <name>A0A7U8THW7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="186" mass="17422" checksum="EB82252288A1EC8B" modified="2021-06-02" version="1">GSGHPDRPAAQRGAGLIGNDGAGGTGDAVSLGRAGTAGGDRRGPVGGIGGAGGVGGAGGAAGAVTTITHASFNDPHGVAVNPGGNVYVTNFGSGTVSVINPATNTVTGSPITIGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPTTNTVTGSPITVGTAPTGVAVNPVTGEVYVTNFAGDTVSVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI68</accession>
    <name>A0A7U8TI68_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transmembrane transporter mmpL13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="668"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="729"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="259"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="812"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="839" mass="89630" checksum="2EA328D56C0AF363" modified="2021-06-02" version="1">MLRRHGGRHRGHAAGEPLERPHPYLWQALFDSCNLSQISHRGFGAGPRDQHRLRRKRNMLQRIARLAIAAPRRIIGFAVFVFIAAAVFGVPVADSLSPGGFQDPRSESARAIEVLTDKFGQSGQKMLIVVTAAAGADSPPAREVGTDIVEVLRRSPLVYNVTSPWTVPPTAAADLLSTDGKSGLIVVNVKGGENDAQNHAQTLSDEVAHDRDGVTVRAGGSAMEYAQINRQNKDDLLVMELIAIPLSFLVLIWVFGGLLAAGLPMAQAVLAVVGSMAVLRLVTFATEVSTFALNLSTALGLALAIDYTLLIVSRYRDELAEGSDRDEALIRTMATSGRTVLFSAVTVALSMSATALFPMYFLKSFAYAGVATVAFVATASIVITPAAIVLLGPRLDALDVRRLVRRLLGRPDPVHKPVKQLFWYRSSKFVMRRWLPVGTAVVALLVLLGLPFLSVKWGFPDDRVLPRSASARQVGDILRDDFGHDPATQIPIVVPDARGLGPVELDSYAAELSRVPDVSAVAAPTGTFVDGSWVGTPRGATGLAEGSAFLTVSSTAPLFSRASDIQLKRLHQVAGPAGRSVVMAGVAQVNRDSVDAVTDRLPMVLGLIAAITYVLLFLLTGSVVLPAKALVCNVLSLTAAFGALVWIFQEGHFGALGTTPSGTLVANMPVLLFCIAFGLSMDYEVFLVSRIREYWLESGAARPARRSVAEVHAANDESVALGVARTGRVITAAALVMSMSFAALIAAHVSFMRMFGLGLTLAVAADATLVRMVVVPAFMHVTGRWNWWAPRPLAWLHERFGVSEAAEPVSRRRSHAGGLGKIAGRSDGQTIPASLTRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIB5</accession>
    <name>A0A7U8TIB5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406254.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIB5"/>
    <dbReference type="GeneID" id="45425189"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041484">
        <property type="entry name" value="TetR_C_25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17933">
        <property type="entry name" value="TetR_C_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="212" mass="23181" checksum="8FBC03B909EA88C0" modified="2021-06-02" version="1">MRSADLTAHARIREAAIEQFGRHGFGVGLRAIAEAAGVSAALVIHHFGSKEGLRKACDDFVAEEIRSSKAAALKSNDPTTWLAQMAEIESYAPLMAYLVRSMQSGGELAKMLWQKMIDNAEEYLDEGVRAGTVKPSRDPRARARFLAITGGGGFLLYLQMHENPTDLRAALRDYAHDMVLPSLEVYTEGLLADRAMYEAFLAEAQQGEAHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIE5</accession>
    <name>A0A7U8TIE5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a quinol + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = a quinone + reduced coenzyme F420-(gamma-L-Glu)(n)</text>
            <dbReference type="Rhea" id="RHEA:39663"/>
            <dbReference type="Rhea" id="RHEA-COMP:12939"/>
            <dbReference type="Rhea" id="RHEA-COMP:14378"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="ChEBI" id="CHEBI:133980"/>
            <dbReference type="ChEBI" id="CHEBI:139511"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the F420H(2)-dependent quinone reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406364.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIE5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004378">
        <property type="entry name" value="F420H2_quin_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04075">
        <property type="entry name" value="F420H2_quin_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00026">
        <property type="entry name" value="hi_GC_TIGR00026"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="149" mass="16756" checksum="D8F22A51B5F43FCF" modified="2021-06-02" version="1">MDISRWLERHVGVQLLRLHDAIYRGTNGRIGHRIPGAPPSLLLHTTGAKTSQPRTTSLTYARDGDAYLIVASKGGDPRSPGWYHNLKANPDVEINVGPKRFGVTAKPVQPHDPDYARLWQIVNENNANRYTNYQSRTSRPIPVVVLTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIM8</accession>
    <name>A0A7U8TIM8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Primosomal protein N priA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="431" mass="45252" checksum="1775825A67AAC1B4" modified="2021-06-02" version="1">MIGTRSAVFAPLSELGLVMVWADADDSLAEPRAPYPHAREVAMLRAHQARCAALIGGYARTAEAHALVRSGWAHDVVAPRPEVRARSPRVVALDDSGYDDARDPAARTARLPSIALRAARSALQSGAPVLVQVPRRGYIPSLACGRCRAIARCRSCTGPLSLQGAGSPGAVCRWCGRVDPTRRCVRCGSDVVRAVVVGARRTAEELGRAFPGTAVITSAGDTLVPQLDAGPALVVATPGAEPRAPGGYGAALLLDSWALLGRQDLRAAEDALWRWMTAAALVRPRGAGGVVTVVAESSIPTVQSLIRWDPVGHAEAELAARTEVGLPPSVHIAALDGPAGTVTALLEAARLPDPDRLQADLLGPVDLPPGVRRPAGIPADAPVIRMLLRVCREQGLELAASLRRGIGVLSARQTRQTRSLVRVQIDPLHIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIQ4</accession>
    <name>A0A7U8TIQ4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407382.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIQ4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD13036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="473" mass="50476" checksum="E274D90D32FFFFE3" modified="2021-06-02" version="1">MTTAVVVGAGPNGLAAAIHLARHGVDVQVLEARDTIGGGARSGELTVPGVIHDHCSAFHPLGVGSPFWAAIDLQRYGLTWKWPDVDCAHPLDDGTAGVLYRSIEATAAGLGPDGKRWQRAVGDLAAGFDELAEDLLRPVLNMPRHPIRLARFGPRAALPATAMARRFHTERARALFGGAAAHVYTRLDRPLTASLGLMILASGHRHGWPVARGGSGSITKALAAALDAYGGTVATGVTVTSRRDIPDADIVMLDLSPAAVLGIYGDVMPTRINRSYRRYRAGSSAFKVDFAIEGDVGWTNPDCRRAGTVHLGGTFAEIADTERQRAQGTMVQRPFVLVGQQYLADPSRSVGNINPIWAYAHVPFGYTGDATAAVIDQIERFAPGFRDRIVATVSTSTTELQTYNRNFIGGDIIGGANDRLQVIFRPRVAVDPYAIGVPGVYLCSQSAPPGAGIHGLCGYHAAESALRWLRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR23</accession>
    <name>A0A7U8TR23_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thump_like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR23"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041497">
        <property type="entry name" value="Thump-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18096">
        <property type="entry name" value="Thump_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thump_like" evidence="1">
        <location>
            <begin position="281"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="358" mass="39082" checksum="4E2B5AECDF5259CA" modified="2021-06-02" version="1">MRARFGDRAPWLVETTLLRRRAAGKLGELCPNVGVSQWLFTDEALQQATAAPVARHRARRLAGRVVHDATCSIGTELAALRELAVRAVGSDIDPVRLAMARHNLAALGMEADLCRADVLHPVTRDAVVVIDPARRSNGRRRFHLADYQPGLGPLLDRYRGRDVVVKCAPGIDFEEVGRLGFEGEIEVISYRGGVREACLWSAGLAGSGIRRRASILDSGEQIGDDEPDDCGVRPAGKWIVDPDGAVVRAGLVRNYGARHGLWQLDPQIAYLSGDRLPPALRGFEVLEQLAFDERRLRQVLSALDCGAAEILVRGVAIDPDALRRRLRLRGSRPLAVVITRIGAGSLSHVTAYVCRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR26</accession>
    <name>A0A7U8TR26_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415928.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR26"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="15"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="212"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="414" mass="44805" checksum="64ADC7A4EA17A0DE" modified="2021-06-02" version="1">MRILMVSWEYPPVVIGGLGRHVHHLSTALAAAGHDVVVLSRCPSGTDPSTHPSSDEVTEGVRVIAAAQDPHEFTFGNDMMAWTLAMGHAMIRAGLRLKKLGTDRSWRPDVVHAHDWLVAHPAIALAQFYDVPMVSTIHATEAGRHSGWVSGALSRQVHAVESWLVRESDSLITCSASMNDEITELFGPGLAEITVIRNGIDAARWPFAARRPRTGPAELLYVGRLEYEKGVHDAIAALPRLRRTHPGTTLTIAGEGTQQDWLIDQARKHRVLRATRFVGHLDHTELLALLHRADAAVLPSHYEPFGLVALEAAAAGTPLVTSNIGGLGEAVINGQTGVSCAPRDVAGLAAAVRSVLDDPAAAQRRARAARQRLTSDFDWQTVATATAQVYLAAKRGERQPQPRLPIVEHALPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR49</accession>
    <name>A0A7U8TR49_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-hydrolase/esterase lipR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901538.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR49"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Abhydrolase_3" evidence="1">
        <location>
            <begin position="72"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="308" mass="32617" checksum="8F9938336F47BAE7" modified="2021-06-02" version="1">MNLRKNVIRSVLRGARPLFASRRLGIAGRRVLLATLTAGARAPKGTRFQRVSIAGVPVQRVQPPHAATSGTLIYLHGGAYALGSARGYRGLAAQLAAAAGMTALVPDYTRAPHAHYPVALEEMAAVYTRLLDDGLDPKTTVIAGDSAGGGLTLALAMALRDRGIQAPAALGLICPWADLAVDIEATRPALRDPLILPSMCTEWAPRYVGSSDPRLPGISPVYGDMSGLPPIVMQTAGDDPICVDADKIETACAASKTSIEHRRFAGMWHDFHLQVSLLPEARDAIADLGARLRGHLHQSQGQPRGVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRM0</accession>
    <name>A0A7U8TRM0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="3">
        <location>
            <begin position="40"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="694" mass="77383" checksum="7CAD70D564F02C86" modified="2021-06-02" version="1">MATIAQRLRDDHGVAASESSVRRWIATHFAEEVARERVTVPRGPVDAGSEAQIDYGRLGMWFDPATARRVAVWAFVMVLAFSRHLFVRPVIRMDQTAWCACHVAAFEFFDGVPARLVCDNLRTGVDKPDLYDPQINRSYAELASHYATLVDPARARKPKDKPRVERPMTYVRDSFWKGREFDSLAQMQQAAVTWSTEVAGLRYLRALEGAQPLRVFEAVEQQALIALPPRAFELTSWSIGTVGVDTHLKVGKALYSVPWRLIGQRLHARTAGDVVQIFAGNDVVATHVRRPSGRSTDFSHYPPEKIAFHMRTPTWCRHTAELVGPACQQVIAEFMRDNAIHHLRSAQGVLGLRDKHGCDRLEAACARAIEVGDPSYRTIKGILVAGTEHAANEPTTSSPASTAGAFLRGPEQFGTDTPRRLISQRNPEPSRHNPHRYSQGEASMSICDPALRNALRTLKLSGMLDTLDARLAQTRNGDLGHLEFLQALREDEIARRESAALTRRLRRAKFEAQATFEDFDFTANPKLPGAMLRDLAALRWLDAGESVILHGPVGVGKTHVAQALVHAVARRGGDVRFAKTSRMLSDLAGGHADRSWGQRIREYTKPLVLILDDFAMREHTAMHADDLYELISDRAITGKPLILTSNRAPNNWYGLFPNPVVAESLLDRLINTSHQILMDGPSYRPRKRPGRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRQ0</accession>
    <name>A0A7U8TRQ0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030667241" description="PE domain-containing protein" evidence="2">
        <location>
            <begin position="34"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="3">
        <location>
            <begin position="4"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="391" mass="33905" checksum="F33E8A6A00A52A2F" modified="2021-06-02" version="1" fragment="single">MSFVIANPEMLAAAATDLAGIRSAISAATAAAAAPTIQVAAAGADEVSLAISALFGQHAQAYQALSAQATIFHDQFVQALTSGGNLYAAAESHTVEQMVLNAINAPTQTLFGRPLIGDGANGTAENPDGQNGGLLFGNGGNGFTQTTAGVAGGNGGSAGLIGNGGAGGGGGAGAAGGLGGNGGWLYGNGGAGGIGGAGTGTGGHGGAGGAGGRAWLWGTGGAGGAGGDGGWLFGDGGAAGAGGNGGNNTSAGTGGVGASGGTGGNAGLIGAGGHGGAGGAGGNQTGGVGNGGAGGNGGAGGAGGQLYGNGGAGGANIAGGNGSDGGAAGHGGAGGSARLIGAGGHGGDGGAGGNTAGRRADAIAGTGGDGGNGGNGGLLSGNAGAGGHGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRR3</accession>
    <name>A0A7U8TRR3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900015.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45428006"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="56" mass="6577" checksum="13BCEE84CD5D4212" modified="2021-06-02" version="1">MNGDSASTIDIDKAVTRTPVRRIVRSALDRLWLRQSQPRRYRFLEDSCMARALNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRS9</accession>
    <name>A0A7U8TRS9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chaperonin GroEL</fullName>
            <ecNumber evidence="9">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Chaperonin-60</fullName>
            <shortName evidence="9">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">groEL</name>
        <name evidence="9" type="synonym">groL</name>
        <name evidence="12" type="ORF">TBLG_03982</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 11">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell surface</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Secreted</location>
            <location evidence="8">Capsule</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="9"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418021.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRS9"/>
    <dbReference type="GeneID" id="45427413"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042603">
        <property type="term" value="C:capsule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="495"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD15084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="539" mass="55877" checksum="3E0B93164C091B63" modified="2021-06-02" version="1">MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFGGPTVTNDGVTVAREIELEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGGLRLVAAGVNPIALGVGIGKAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLVGEAMSKVGHDGVVSVEESSTLGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQDKISSLPDLLPLLEKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGDRRKAFLEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAVANRAKHLRAEIDKSDSDWDREKLGERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAAKAAVEEGIVPGGGASLIHQARKALTELRASLTGDEVLGVDVFSEALAAPLFWIAANAGLDGSVVVNKVSELPAGHGLNVNTLSYGDLAADGVIDPVKVTRSAVLNASSVARMVLTTETVVVDKPAKAEDHDHHHGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRV7</accession>
    <name>A0A7U8TRV7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="178" mass="19838" checksum="0F70ED029DA1FBAF" modified="2021-06-02" version="1">MHPMIPAEYISNIIYEGPGADSLSAAAEQLRLMYNSANMTAKSLTDRLGELQENWKGSSSDLLADAAGRYLDWLTKHSRQILETAYVIDFLAYVYEETRHKVVPPATIANNREEVHRLIASNVAGVNTPAIADLDAQYDQYRAQNIAVMNDYQSTARFILAYLPRWQEPPQIYGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRW0</accession>
    <name>A0A7U8TRW0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="69" mass="7927" checksum="414CDC789DDE43B5" modified="2021-06-02" version="1">MTNRAGTGRRGSSVTVDEVPDPQVPERAQRRTFTVKYKLAILDEYDRADRTERGAILRRENLYSSLLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRX8</accession>
    <name>A0A7U8TRX8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmJ</name>
        <name evidence="6" type="ORF">TBLG_04114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418367.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRX8"/>
    <dbReference type="GeneID" id="45427450"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="37" mass="4343" checksum="C92A4845315F930F" modified="2021-06-02" version="1">MKVNPSVKPICDKCRLIRRHGRVMVICSDPRHKQRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TS47</accession>
    <name>A0A7U8TS47_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="74" mass="5719" checksum="21E7C72A4A46576C" modified="2021-06-02" version="1" fragment="single">MNGGDGGAGGQGGDGAAGDAAASAGGTGGKGGQGGDGGTGGAGGAGPVLFGHGGAGGMGGQGGTGGMGGAGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSR2</accession>
    <name>A0A7U8TSR2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bac_luciferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="155" mass="17290" checksum="AED1BFDDBFFDEDE5" modified="2021-06-02" version="1">EVANHGVDPAVRGRVIDERLRAIIEIWTQEQAEFHGTYVDFDPIYCWPKPVTKPYPPLYVGGGPANFPRIARLNAGWIAISPSPQRLSGPLQRLRAMAGGDVPVTVCQWGEAAAKDLEGYRHLGVERVLLELPTEPRDPTLRYLDKLQAELARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT14</accession>
    <name>A0A7U8TT14_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="PTHR12318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="13"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="288" mass="31515" checksum="ECA6C161039A9839" modified="2021-06-02" version="1">MNSPREPLVPPPTPRPAATVMLVRDPDAGSASGLAVFLMRRHAAMDFAAGVMVFPGGGVDDRDRDADLGRLGAWAGPPPQWWAQRFGIEPDLAEALVCAAARETFEESGVLFAGPVDQDHSAPNSIVSDASVYGDARRALADRTLSFADFLQREKLVLRSDLLRPWANWVTPEAELTRRYDTYFFVGALPEGQRADGENTESDRAGWVLPADAIADFAAGRNFLLPPTWTQLDSLAGHTVADVLAVERQIVPVQPQLARNGDNWEIEFFDSDRYNQTRRSGGSTGWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT37</accession>
    <name>A0A7U8TT37_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">crcB</name>
        <name evidence="10" type="ORF">TBLG_03690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416046.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT37"/>
    <dbReference type="GeneID" id="45427064"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD14792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="126" mass="13167" checksum="70D57B2A80C9AC3D" modified="2021-06-02" version="1">MTASTALTVAIWIGVMLIGGIGSVLRFLVDRSVARRLARTFPYGTLTVNITGAALLGFLAGLALPKDAALLAGTGFVGAYTTFSTWMLETQRLGEDRQMVSALANIVVSVVLGLAAALLGQWIAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT55</accession>
    <name>A0A7U8TT55_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03894</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417056.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT55"/>
    <dbReference type="GeneID" id="45427250"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="346" mass="35309" checksum="8998BAB502550844" modified="2021-06-02" version="1">MNVARAIDLEDTEGLIAADRGALLRAASMAGAQVRAIAAAADEGELDLLRGSDRPRSVIWVTGRGTAETAGTILASTLGAGAAEPIVLASAAPPWVGPLDVLIVAGDDPGDPALVGAAAIGVRRGARVVVVAPYEGPLRDSTAGRVAVLEPRLRVPDEFGLSRYLAAGLAALQTVDPKLRIDLASLADELDAEALRNSAGREVFTNPAKALAARVSGCQLALAGDNAATLALARHGSSVMLRIANQVVAATRLSDAVVALRAGTPPDALFHDEEIDGPAPQRLRVLALALAGERTVVAARVAGLDDAYLVAAEDVPELLDAPVGSGGAVLAVRLEMAAVYLRLVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT96</accession>
    <name>A0A7U8TT96_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="5">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nuoN</name>
        <name evidence="8" type="ORF">TBLG_03780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900644.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT96"/>
    <dbReference type="GeneID" id="45427145"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0874">Quinone</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="169"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="531" mass="55342" checksum="45A17C8F3E57BBA1" modified="2021-06-02" version="1">MILPAPHVEYFLLAPMLIVFSVAVAGVLAEAFLPRRWRYGAQVTLALGGSAVALIAVIVVARSIHGSGHAAVLGAIAVDRATLFLQGTVLLVTIMAVVFMAERSARVSPQRQNTLAVARLPGLDSFTPQASAVPGSDAERQAERAGATQTELFPLAMLSVGGMMVFPASNDLLTMFVALEVLSLPLYLMCGLARNRRLLSQEAAMKYFLLGAFSSAFFLYGVALLYGATGTLTLPGIRDALAARTDDSMALAGVALLAVGLLFKVGAVPFHSWIPDVYQGAPTPITGFMAAATKVAAFGALLRVVYVALPPLHDQWRPVLWAIAILTMTVGTVTAVNQTNVKRMLAYSSVAHVGFILTGVIADNPAGLSATLFYLVAYSFSTMGAFAIVGLVRGADGSAGSEDADLSHWAGLGQRSPIVGVMLSMFLLAFAGIPLTSGFVSKFAVFRAAASAGAVPLVIVGVISSGVAAYFYVRVIVSMFFTEESGDTPHVAAPGVLSKAAIAVCTVVTVVLGIAPQPVLDLADQAAQLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTD3</accession>
    <name>A0A7U8TTD3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415939.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTD3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021729">
        <property type="entry name" value="DUF3298"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037126">
        <property type="entry name" value="PdaC/RsiV-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11738">
        <property type="entry name" value="DUF3298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031316544" evidence="1">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3298" evidence="2">
        <location>
            <begin position="145"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="227" mass="24407" checksum="0F2C73D55F4B348B" modified="2021-06-02" version="1">MRYLIATAVLVAVVLVGWPAAGAPPSCAGLGGTVQAGQICHVHASGPKYMLDMTFPVDYPDQQALTDYITQNRDGFVNVAQGSPLRDQPYQMDATSEQHSSGQPPQATRSVVLKFFQDLGGAHPSTWYKAFNYNLATSQPITFDTLFVPGTTPLDSIYPIVQRELARQTGFGAAILPSTGLDPAHYQNFAITDDSLIFYFAQGELLPSFVGACQAQVPRSAIPPLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTJ7</accession>
    <name>A0A7U8TTJ7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, asnC-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="4">
        <location>
            <begin position="5"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="150" mass="16489" checksum="8E95E92133D13338" modified="2021-06-02" version="1">MNEALDDIDRILVRELAADGRATLSELATRAGLSVSAVQSRVRRLESRGVVQGYSARINPEAVGDLLSAFVAITPLDPSQPDDAPARLEHIEEVESCYSVAGEESYVLLVRVASARALEDLLQRIRTTANVRTRSTIILNTFYSDRQHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTL5</accession>
    <name>A0A7U8TTL5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase iron-sulfur protein subunit sdhB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417279.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTL5"/>
    <dbReference type="GeneID" id="45427319"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="263" mass="29335" checksum="F09FE9396750C594" modified="2021-06-02" version="1">MSVEPDVETLDPPLPPVPDGAVMVTVKIARFNPDDPDAFAATGGWQSFRVPCLPSDRLLNLLIYIKGYLDGTLTFRRSCAHGVCGSDAMRINGVNRLACKVLMRDLLPKKKGKSLTVTVEPIRGLPVEKDLVVDMEPFFDAYRAIKPYLITSGNPPTRERIQSPTDRARYDDTTKCILCACCTTSCPVFWHEGSYFGPAAIVNAHRFIFDSRDEAAAERLDILNEVDGVWRCRTTFNCTESCPRGIEVTKAIQEVKRALMFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TU98</accession>
    <name>A0A7U8TU98_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_04102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EccD/Snm4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900062.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TU98"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044049">
        <property type="entry name" value="EccD_transm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006707">
        <property type="entry name" value="T7SS_EccD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024962">
        <property type="entry name" value="YukD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19053">
        <property type="entry name" value="EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08817">
        <property type="entry name" value="YukD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017804">
        <property type="entry name" value="Secretion_EccD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03920">
        <property type="entry name" value="T7SS_EccD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="EccD" evidence="6">
        <location>
            <begin position="96"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="467" mass="46731" checksum="91FF9CD1FD51F2F4" modified="2021-06-02" version="1">MPTSDPGLRRVTVHAGAQAVDLTLPAAVPVATLIPSIVDILGDRGASPATAARYQLSALGAPALPNATTLAQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAVAAALDTTARPQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAAGLAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLVAAMAAAATSVLAMRITGCGGITLTAVACCAVVVAAATLVGAITAAPVPAIGSLATLASFGLLEVSARMAVLLAGLSPRLPPALNPDDADALPTTDRLTTRANRADAWLTSLLAAFAASATIGAIGTAVATHGIHRSSMGGIALAAVTGALLLLRARSADTRRSLVFAICGITTVATAFTVAADRALEHGPWIAALTAMLAAVAMFLGFVAPALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TUA8</accession>
    <name>A0A7U8TUA8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 6">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_04117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 6"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418607.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TUA8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="331" mass="37558" checksum="10652C75423082D2" modified="2021-06-02" version="1">MRLLVTGGAGFIGTNFVHSAVREHPDDAVTVLDALTYAGRRESLADVEDAIRLVQGDITDAELVSQLVAESDAVVHFAAESHVDNALDNPEPFLHTNVIGTFTILEAVRRHGVRLHHISTDEVYGDLELDDRARFTESTPYNPSSPYSATKAGADMLVRAWVRSYGVRATISNCSNNYGPYQHVEKFIPRQITNVLTGRRPKLYGAGANVRDWIHVDDHNSAVRRILDRGRIGRTYLISSEGERDNLTVLRTLLRLMDRDPDDFDHVTDRVGHDLRYAIDPSTLYDELCWAPKHTDFEEGLRTTIDWYRDNESWWRPLKDATEARYQERGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y206</accession>
    <name>A0A7U8Y206_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, gntR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403065.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y206"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="240" mass="26509" checksum="A0AA26FD6BFF8FB8" modified="2021-06-02" version="1">MALQPVTRRSVPEEVFEQIATDVLTGEMPPGEALPSERRLAELLGVSRPAVREALKRLSAAGLVEVRQGDVTTVRDFRRHAGLDLLPRLLFRNGELDISVVRSILEARLRNFPKVAELAAERNEPELAELLQDSLRALDTEEDPIVWQRHTLDFWDHVVDSAGSIVDRLMYNAFRAAYEPTLAALTTTMTAAAKRPSDYRKLADAICSGDPTGAKKAAQDLLELANTSLMAVLVSQASRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y266</accession>
    <name>A0A7U8Y266_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019710">
        <property type="entry name" value="DUF4226"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10774">
        <property type="entry name" value="DUF4226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="259" mass="28526" checksum="0B9A309B79CA90DE" modified="2021-06-02" version="1">MALTQHIGVSAETDRAVVPKLRQAYDSLVCGRRRLGAIGAEIENAVAHQRALGLDTPAGARNFSRFLATKAHDITRVLAATAAESQAGAARLRSLASSYQAVGFGPKPQEPPPDPVPFPPYQPKVWAACRARGQDPDKVVRTFHHAPMSARFRSLPAGDSVLYCGNDKYGLLHIQAKHGRQWHDIADARWPSAGNWRYLADYAIGATLAYPERVEYNQDNDTFAVYRRMSLPDGRYVFTTRVIISARDGKIITAFPQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y275</accession>
    <name>A0A7U8Y275_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH tetR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403915.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y275"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="29"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="213" mass="22572" checksum="75A7FDEAFB9B0743" modified="2021-06-02" version="1">MSSDVLVTTPAQRQTEPHAEAVSRNRRQQATFRKVLAAAMATLREKSYADLTVRLVAARAKVAPATAYTYFSSKNHLIAEVYLDLVRQVPCVTDVNVPMPIRVTSSLRHLALVVADEPEIGAACTAALLDGGADPAVRAVRDRIGAEIHRRITSAIGPGADPGTVFALEMAFFGALVQAGSGTFTYHEIADRLGYVVGLILAGANEPSTGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2E8</accession>
    <name>A0A7U8Y2E8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="PTHR12670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ceramidase_alk" evidence="1">
        <location>
            <begin position="3"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="58" mass="6282" checksum="40EE42E63DD4457A" modified="2021-06-02" version="1" fragment="single">MLSVGRGIADITGEAADCGMLGYGKSDQRTAGIHQRLRSRAFVFRDDSQDGDARLLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2F8</accession>
    <name>A0A7U8Y2F8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, tetR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405271.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2F8"/>
    <dbReference type="GeneID" id="45424991"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="197" mass="21702" checksum="9405F1D695ECE253" modified="2021-06-02" version="1">MTGTERRHQLIGIARSLFAERGYDGTSIEEIAQRANVSKPVVYEHFGGKEGLYAVVVDREMSALLDGITSSLTNNRSRVRVERVALALLTYVEERTDGFRIMIRDSPASISSGTYSSLLNDAVSQVSSILAGDFARRGLDPDLAPLYAQALVGSVSMTAQWWLDAREPKKEVVAAHLVNLVWNGLTHLEADPRLQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2P3</accession>
    <name>A0A7U8Y2P3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-xylulose kinase xylB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FGGY_N" evidence="1">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="FGGY_C" evidence="2">
        <location>
            <begin position="290"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="448" mass="46560" checksum="2C38A8CBEC960D9E" modified="2021-06-02" version="1">MSRDDVTIGIDIGTTAVKAVAADDNGRVTARVRIGHQLAVPAPDRLEHDADEAWRRGPLAALDRLVGPDTRALAVAAMVPSLTAVDPAGRPITPGLLYGDARGRVPNASVARAQSVPSVGETAEFLRWTAGQAPDASGYWPAPAVANYALSGEAVIDYATAVTTLPLFDGTGWNATACADCGVTVDRMPRVETFGVGVGQVRGTGAVLAVGAVDALCEQIVAGADRDGDVLVLCGATLIVWTTISAARQVPGLWTIPHTAPGKSQIGGASNAGGLFLNWVDRVIGPGDPALADPRRVPVWLPYIRGERTPFHEPDRRAVLDGVDLSQDAASVRRAAYEASGFVVRQLIELSGAPVARIVAAGGGTRIQPWMQAIADATGRPVEVSRVAEGAALGAAFLGRLAAGLESSIADAARWASTDRIVEPSADWAGPTKERYRRFLALSGSKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2S0</accession>
    <name>A0A7U8Y2S0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404298.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021373">
        <property type="entry name" value="DUF2993"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11209">
        <property type="entry name" value="LmeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030575798" evidence="1">
        <location>
            <begin position="28"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="270" mass="28568" checksum="DA139EB88555EE6C" modified="2021-06-02" version="1">MPMRKVLVGVTGAAIVVAVLIVGAVGADFGASIYAEYRLSTTVRKAANLRSDPFVAILRFPFIPQAMREHYAELEIKAFAVEHAGSGTATLEATMHSIDLSYASWLIRPDAKLPVGELESRIIIDSMHLGRYLGISDLMVAAPRQESNDATGGTTESGISGSRGLVFSGTPISANFAHRVSVLVDLSVASDDRATLVITPTAVVTGPDTADQPVPDDKRDAVLHAFASKLPNQKLPFGVVPNTVGARGSDVIIEGITRGVTISLDEFKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2T0</accession>
    <name>A0A7U8Y2T0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Biotin sulfoxide reductase bisC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407419.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2T0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02793">
        <property type="entry name" value="MopB_CT_DMSOR-BSOR-TMAOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006658">
        <property type="entry name" value="BisC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041954">
        <property type="entry name" value="CT_DMSOR/BSOR/TMAOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041460">
        <property type="entry name" value="Molybdopterin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18364">
        <property type="entry name" value="Molybdopterin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00509">
        <property type="entry name" value="bisC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Molybdopterin_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="Molybdopterin" evidence="3">
        <location>
            <begin position="50"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Molydop_binding" evidence="4">
        <location>
            <begin position="623"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD13049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="766" mass="83390" checksum="C74E74F9FDEAC2BA" modified="2021-06-02" version="1">MQVYTSATHWGVFTARVHGGDIAAVAALASDTNPAPQLQNLPGAVRHRSRIANPAVRRGWLQHGPGPSSARGAEEFVEVSWDELIELLASELRRTVDRYGNEAIYGSSYGWASAGRFHHAQSQVHRFLNMLGGYTASRHSYSAGASEVIFPHIVGAALFEALAETTTWDVIVDHTALLVAFGGLPVKNTAVMPGGTTAHPDRDYVGRYRARGGRLVSVSPLRDDIAAIAGPLDDRCRWLAPVPGTDVAIMLGLAYVLATESLADRAFLGRYCTGYERFERYLLGLDDGIPKTPEWAAALSGLAAGDLRDLARRMAEHRTLITTSLSLQRIEHGEQTVWMAATLAAMLGQIGLPGGGFGHGYSSNGVGNPPLACGLPALPQGNNPVSTFIPVAAISELLQRPGQRLAYNGRLLELPDIKCVYWAGGNPFHHHQNLPRLRRALSRVDTIVVHEQYWTAMAKHADIVVPTTTSFERDDFAASKTNPTLIAMPAMVPPYANARDDYHTFSALAHRLGFGKQFTEGRSAREWLEHMYDKWSAELDFPVPSFAEFWRTGRLELPTRTGLTWLADFRADPAAHPLGTPSGRIEIFSDTVDAFALPDCAGHPTWYEPSEWLGGPRAARYPLHLIANQPRTRLHSQLDHGGASMASKIRGREPIRIHPDDAAARELTDGDIVRVFNDRGACLAGVVIDDGLRPKVVQLSTGAWFDPADPRDPDSMCVHGNPNALSNDSGTSSLAHGSTGQHVLVQIERFTGELPPVRAHEPPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Z2</accession>
    <name>A0A7U8Y2Z2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="208" mass="23047" checksum="5D1A5A4B011B9706" modified="2021-06-02" version="1">MSVPRRTPNSHAPAGPVPDFLRHRYETSTHRVICLRSVPKTSGIGAVEALTPSTAGRAGLAQRALPRRAGRPLGPHRPRHLPTRRRVDRRLGSDRGRHAPPRRYDLPGLRTHAPRPDRRDPRRAGHRHPPLVEDTGQHRRDCVAPLRPGHILDRTRRDHDPGIGSDNRNLTHPSARSPIHSGSATKSVTNWRVTRCESGCAEAANPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y314</accession>
    <name>A0A7U8Y314_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y314"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="164" mass="18061" checksum="2356C01F54E2EEDA" modified="2021-06-02" version="1">MLSGGREAVKTVWQTANLVRKEGFGAAVRSSIEDPADWAEVERPDLARVTPDGRVVILFSDIEESTALDERIGDRTWVKLIGAHDKLVHELVRRWSGHMVTSQGDGFMIAFARAEQAVRCGIDIQDALRNSAKRKRNQGIRVRIGTTWGARCGTVTICSAATSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y356</accession>
    <name>A0A7U8Y356_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Drug-transport membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="20"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="579" mass="60809" checksum="A3BAACE3D1D99394" modified="2021-06-02" version="1">MTTAIRRAAGSSYFRNPWPALWAMMVGFFMIMLDSTVVAIANPTIMAQLRIGYATVVWVTSAYLLAYAVPMLVAGRLGDRFGPKNLYLIGLGVFTVASLGCGLSSGAGMLIAARVVQGVGAGLLTPQTLSTITRIFPAHRRGVALGAWGTVASVASLVGPLAGGALVDSMGWEWIFFVNVPVGVIGLILAAYLIPALPHHPHRFDWFGVGLSGAGMFLIVFGLQQGQSANWQPWIWAVIVGGIGFMSLFVYWQARNAREPLIPLEVFNDRNFSLSNLGIAIIAFAGTGMMLPVTFYAQAVCGLSPTHTAVLFAPTAIVGGVLAPFVGMIIDRSHPLCVLGFGFSVLAIAMTWLLCEMAPGTPIWRLVLPFIALGVAGAFVWSPLTVTATRNLRPHLAGASSGVFNAVRQLGAVLGSASMAAFMTSRIAAEMPGGVDALTGPAGQDATVLQLPEFVREPFAAAMSQSMLLPAFVALFGIVAALFLVDFTGAAVAKEPLPESDGDADDDDYVEYILRREPEEDCDTQPLRASRPAAAAASRSGAGGPLAVSWSTSAQGMPPGPPGRRAWQADTESTAPSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y463</accession>
    <name>A0A7U8Y463_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898562.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027948">
        <property type="entry name" value="DUF4436"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14494">
        <property type="entry name" value="DUF4436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="313" mass="33925" checksum="D22397ADAFEE870F" modified="2021-06-02" version="1">MAGSDPPTGGPASQAGSDAGASPEHKHMSRRKHLVLDVCIILGVLIAYVFSLLGYDWLAHTPGPLPQPDVGTTDDTVVLIRFEELHTVANRLDVKVLVLPDDSMIDHRLQVLTTDTSVRLYPENELGDLQYPVGKLPAQVATTIEAHGNPGAWPFDTYTTDTVQADVLVGAGDNRQYVPARVEVTGSLEGWDISAVRVGESSQTSDRPDNVIITLKRAKGPLVFDLGICLVLITLPTLALFVAIQMITGRRKFQPPFGTWYAAMLFAVVPLRTILPGSPPAGAWIDRAVVIWVLIALAAAMVVYIVAWYRESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4C0</accession>
    <name>A0A7U8Y4C0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403266.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4C0"/>
    <dbReference type="GeneID" id="45424589"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="28"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="237" mass="25928" checksum="D5D9947D0261434F" modified="2021-06-02" version="1">MSKDRLYFRQLLSGRDFAVGDMFATQMRNFAYLIGDRTTGDCVVVDPAYAAGDLLDALESDDMQLSGVLVTHHHPDHVGGSMMGFQLPGLAELLERASVPVHVNTHEALWVSRVTGIPVGDLITHEHGDKVSVGDIDIELLHTPGHTPGSQCFLLDGRLVAGDTLFLEGCGRTDFPGGDSDEMYRSLRQLAELPGDPTVFPGHWYSAEPSASLSEVKRSNYVYRPASLDQWRMLMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4F6</accession>
    <name>A0A7U8Y4F6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03127</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsoR family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404935.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4F6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003735">
        <property type="entry name" value="Metal_Tscrpt_repr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038390">
        <property type="entry name" value="Metal_Tscrpt_repr_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33677">
        <property type="entry name" value="PTHR33677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02583">
        <property type="entry name" value="Trns_repr_metal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="119" mass="12800" checksum="87C758FDE4467719" modified="2021-06-02" version="1">MSKELTAKKRAALNRLKTVRGHLDGIVRMLESDAYCVDVMKQISAVQSSLERANRVMLHNHLETCFSTAVLDGHGQAAIEELIDAVKFTPALTGPHARLGGAAVGESATEEPMPDASNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4N3</accession>
    <name>A0A7U8Y4N3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4N3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="14"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="257" mass="27170" checksum="1BB77C089CC94ED5" modified="2021-06-02" version="1">MVAVSTAAKSPTALAIAVRTQDSVVILTADGALDSSSSALLRDSLTRATLEQPSAVIVNVTELQVAEESAWSVFISARWQADFRADVPVLLVCGHRAGRAAVTRTGVARFMPVYPTEKAASKAIGRLARRNFKRSDAQLPANLNSLRESRQLVREWLTQWSRPGLIPVALVVVNVFVENVLKHTGSDPVMRIESDGPTATIAVSDGSSAPAVRLASPPKGIDVSGLAIVAALSRAWGSSPTSSGKTVWAIIGPENQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y528</accession>
    <name>A0A7U8Y528_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="4 8">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fmt</name>
        <name evidence="12" type="ORF">TBLG_03594</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 8">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="4 8"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900336.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y528"/>
    <dbReference type="GeneID" id="45425384"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="10">
        <location>
            <begin position="3"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="11">
        <location>
            <begin position="204"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Tetrahydrofolate (THF) binding" evidence="8">
        <location>
            <begin position="110"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD13010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="312" mass="32692" checksum="1AD300DE45E39E2F" modified="2021-06-02" version="1">MRLVFAGTPEPALASLRRLIESPSHDVIAVLTRPDAASGRRGKPQPSPVAREAAERGIPVLRPSRPNSAEFVAELSDLAPECCAVVAYGALLGGPLLAVPPHGWVNLHFSLLPAWRGAAPVQAAIAAGDTITGATTFQIEPSLDSGPIYGVVTEVIQPTDTAGDLLKRLAVSGAALLSTTLDGIADQRLTPRPQPADGVSVAPKITVANARVRWDLPAAVVERRIRAVTPNPGAWTLIGDLRVKLGPVHLDAAHRPSKPLPPGGIHVERTSVWIGTGSEPVRLGQIQPPGKKLMNAADWARGARLDLAARAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7F1</accession>
    <name>A0A7U8Y7F1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416407.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046179">
        <property type="entry name" value="DUF6188"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19686">
        <property type="entry name" value="DUF6188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="142" mass="15935" checksum="6B83B45E7651B8D5" modified="2021-06-02" version="1">MTEQEMTEQWLEGCAVQRIMFRDGLVLNFDDYNELVISVPLQLTLPAIETSPAEVVAIDPNDPADHERPLFDFAGATCTAFVWYDTGDLHLEFSDGHQIDVHPDDRVTAWELYGKYHGYAACLAPGKLRVVRHDVADANGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7N8</accession>
    <name>A0A7U8Y7N8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030858130" evidence="1">
        <location>
            <begin position="29"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="87" mass="8809" checksum="8A0E3D68891DA67E" modified="2021-06-02" version="1">MMSRQTFLRGAVGAPATSAVFPTILARATPGDGWASLASSIGGQVLLPANGRAFTSGKQIFNSNYSGLNPAAVVTVASQADVRKAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y831</accession>
    <name>A0A7U8Y831_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TsaD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418038.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y831"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="40"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="211" mass="21572" checksum="EC7705833AD1E4BC" modified="2021-06-02" version="1">MSRVQISTVLAIDTATPAVTAGIVRRHDLVVLGERVTVDARAHAERLTPNVLAALADAALTMADLDAVVVGCGPGPFTGLRAGMASAAAYGHALGIPVYGVCSLDAIGGQTIGDTLVVTDARRREVYWARYCDGIRTVGPAVNAAADVDPGPALAVAGAPEHAALFALPCVEPSRPSPAGLVAAVNWADKPAPLVPLYLRRPDAKPLAVCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y876</accession>
    <name>A0A7U8Y876_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplQ</name>
        <name evidence="7" type="ORF">TBLG_04109</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418346.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y876"/>
    <dbReference type="GeneID" id="45427445"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="180" mass="19475" checksum="BCA33FB5ED6DE99F" modified="2021-06-02" version="1">MPKPTKGPRLGGSSSHQKAILANLATSLFEHGRITTTEPKARALRPYAEKLITHAKKGALHNRREVLKKLRDKDVVHTLFAEIGPFFADRDGGYTRIIKIEARKGDNAPMAVIELVREKTVTSEANRARRVAAAQAKAKKAAAMPTEESEAKPAEEGDVVGASEPDAKAPEEPPAEAPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y8B2</accession>
    <name>A0A7U8Y8B2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02985</name>
        <name evidence="4" type="ORF">TBLG_03808</name>
        <name evidence="5" type="ORF">TBLG_03969</name>
        <name evidence="6" type="ORF">TBLG_04019</name>
        <name evidence="7" type="ORF">TBLG_04077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y8B2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="108" mass="12005" checksum="3C092518827DABBB" modified="2021-06-02" version="1">MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVGCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELDRPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9X9</accession>
    <name>A0A7U8Y9X9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical proline rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416124.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427102"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="145" mass="15600" checksum="39DF4DE30C0763FC" modified="2021-06-02" version="1">MKLSNQKRHWPGYLFGRIRTSTLVLIAAFLAVWWIYETYRPQAPGPGDSPPTQVVPPGFVPDPDYTWVPRTRVQPPTVKATPTTTSSTPPVSPPETTTDSAVPPPFELPPPFGPGTTTPTPPAPLPQPGPGPTAGTYPKSEPPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA01</accession>
    <name>A0A7U8YA01_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein moeB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="297"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="389" mass="41610" checksum="50D1E4A8801A6885" modified="2021-06-02" version="1">MTEALIPAPSQISLTRDEVRRYSRHLIIPDIGVNGQQRLKDARVLCIGAGGLGSPALLYLAAAGVGTIGIIDGDHVDESNLQRQIIHGTSDVGRPKVESAAEAVAEINPHVRVTQYREMLTHDNALAIFGDHDLIVDGTDNFTTRYLINDAAVLAGKPYVWGSIYRFNGQTSVFWPGRGPCYRCLHPAPPPPGLVPSCAEGGVLGAICATIASIQVTEVLKLLTGVGTPLVGRLLMYEALDATYHQIRIAKNPDCAICGDAPTITELVDDSVSCASTQSVDPELVISCDELRTKQQSDQNFLLVDVREPAEFDIAHIPGSILIPKGEIGSAAGLAQLPLDKEIVLYCKSGIRSAQALTTLKAAGLHNVKHLDGGIAEWTRTIDSSLLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA35</accession>
    <name>A0A7U8YA35_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Epoxide hydrolase mesT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416627.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA35"/>
    <dbReference type="GeneID" id="45427164"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="318" mass="35230" checksum="66C4ABF8DEBAD84A" modified="2021-06-02" version="1">MTHRASALISAQEWFSAGERVGYDAERPGINPRSPLRAFIRRAAGTGVTRTFLPGWPDGSYGWAKVEAFLSSRFHFPRIYLDYIGHGDSDKPRDYPYSTFERADLVEALWHAEGIAQTVVVAFDYSCIVSLELLARRIDRERAGNDQRTRITACLLANGGIFADGHTHAWYTTPLLTSPLGAAITPIGQRSWRMFAPFLRPVFSRGYPLSAAEMKELHDAISRRDGVRVLPATAGFVDEHREHAARWDLARIISALGDEVAFGVVGSAEDPFEGEQLRLARERLADSVEITELAGGHLTTAEQPDRLAEVIAALPERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA96</accession>
    <name>A0A7U8YA96_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_03992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417998.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA96"/>
    <dbReference type="GeneID" id="45427404"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="2"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="136" mass="14728" checksum="0BED0252F1A06E2A" modified="2021-06-02" version="1">MIYMDTSALTKLLISEPETTELRTWLTAQSGQGEDAATSTLGRVELMRVVARYGQPGQTERARYLLDGLDILPLTEPVIGLAETIGPATLRSLDAIHLAAAAQIKRELTAFVTYDHRLLSGCREVGFVTASPGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAD6</accession>
    <name>A0A7U8YAD6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">truA</name>
        <name evidence="9" type="ORF">TBLG_04108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="137"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="256" mass="28092" checksum="7B7BCF155C625B1C" modified="2021-06-02" version="1">MGQRTVAGDLDAALTTIFRTPVRLRAAGRTDAGVHASGQVAHVDVPADALPNAYPRAGHVGDPEFLPLLRRLGRFLPADVRILDITRAPAGFDARFSALRRHYVYRLSTAPYGVEPQQARYITAWPRELDLDAMTAASRDLMGLHDFAAFCRHREGATTIRDLQRLDWSRAGTLVTAHVTADAFCWSMVRSLVGALLAVGEHRRATTWCRELLTATGRSSDFAVAPAHGLTLIQVDYPPDDQLASRNLVTRDVRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAE0</accession>
    <name>A0A7U8YAE0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAE0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="177" mass="18585" checksum="AC1ED301C6E9D1CE" modified="2021-06-02" version="1">MSTRPERERASTSTDAVLQATVALSAGHKPAFRGFVKDPPRARAHAAAMFVSNAREAEPFVAPDLSEIRVLVDRATVGVASVSLAHATVAAGAETVWHRLQATDEIYFVLSGRGLVSVGDESGEVGPGDAVWIPAGVPQKIRALGSVPLTFLCACGPAYLPERDQRMGEAAVIGAWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAF1</accession>
    <name>A0A7U8YAF1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxidase bpoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="261" mass="28136" checksum="B522FFA0F8E93595" modified="2021-06-02" version="1">MVFLHGGGQTRRSWGRAAAAVAESGWQAVTIDLRGHGESDWSSEGDYRLVSFAGDIQEVLRNLPGQPALVGASLGGFAAMLLAGELSPGIASAVVLVDIVPNMDLAGASRIHAFMAERVESGFGSLDEVADVIANYNPHRPRPSDPDGLVANLRRRGDRWYWHWDPQFIGGIAAFPPVEVTDVDRMNAAVATILRDEVPVLLVRGQVSDIVRQESADQFLSRFPQVEFTDVRGAGHMVAGDRNDAFAGAVLDFLARHVGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF87</accession>
    <name>A0A7U8TF87_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900723">
        <property type="term" value="P:negative regulation of protein adenylylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11586">
        <property type="entry name" value="VbhA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033788">
        <property type="entry name" value="VbhA-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="304" mass="33405" checksum="DE2DC1FEC1D8F5CB" modified="2021-06-02" version="1">MDDELRGLLARYARGELSADDARRAILRYPKWRVAEIDGELETVALDDGTPMLIAESSASDGREYSGLELVRDIAPLVGGLSFDPDEPWGSAFRPGALPELQSWARTVELEDAVAKPGPGQRDLLYEGPWWVAVSPGTGRPAVHRADGLDVITIMTAPDAAATFRRTERHRGLDVVRLGPALWGDLAKRSDFDGVRLNPLRPLAQLWPPHVPAMLVAGCDPRPNAEPLPARTVAEIHLWLDQHGARQEKRELSNRATPVGEVTVARAWWNYDRREIAFTRVAPASDTEGLGSVPSRILCAGKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFA3</accession>
    <name>A0A7U8TFA3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methoxy mycolic acid synthase 4 mmaA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFA3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="77"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="103"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="132"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="301" mass="34670" checksum="827ED04835956802" modified="2021-06-02" version="1">MTRMAEKPISPTKTRTRFEDIQAHYDVSDDFFALFQDPTRTYSCAYFEPPELTLEEAQYAKVDLNLDKLDLKPGMTLLDIGCGWGTTMRRAVERFDVNVIGLTLSKNQHARCEQVLASIDTNRSRQVLLQGWEDFAEPVDRIVSIEAFEHFGHENYDDFFKRCFNIMPADGRMTVQSSVSYHPYEMAARGKKLSFETARFIKFIVTEIFPGGRLPSTEMMVEHGEKAGFTVPEPLSLRPHYIKTLRIWGDTLQSNKDKAIEVTSEEVYNRYMKYLRGCEHYFTDEMLDCSLVTYLKPGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFE5</accession>
    <name>A0A7U8TFE5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8 11">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rplV</name>
        <name evidence="13" type="ORF">TBLG_02850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="7">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8 11">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 10">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403587.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFE5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="118"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="197" mass="20380" checksum="8BD60E2D09B47D18" modified="2021-06-02" version="1">MTAATKATEYPSAVAKARFVRVSPRKARRVIDLVRGRSVSDALDILRWAPQAASGPVAKVIASAAANAQNNGGLDPATLVVATVYADQGPTAKRIRPRAQGRAFRIRRRTSHITVVVESRPAKDQRSAKSSRARRTEASKAASKVGATAPAKKAAAKAPAKKAPASSGVKKTPAKKAPAKKAPAKASETSAAKGGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFI0</accession>
    <name>A0A7U8TFI0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="120" mass="10423" checksum="33BD0ABB3FA51B1D" modified="2021-06-02" version="1" fragment="single">RGVDGAGGKAGLLIGNGGAGGAGGQGAVTGGTGGAGGDGVLIGNGGNAGIGGTGPTAGDTGAGGISGLLLGADGFNAPASASPLHTLKQQALAAINAPTQTLTGRPLIGNGTPGAVGSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFN4</accession>
    <name>A0A7U8TFN4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-[acyl-carrier protein] desaturase desA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_02970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="7">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fatty acid desaturase type 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404321.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFN4"/>
    <dbReference type="GeneID" id="45424787"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045300">
        <property type="term" value="F:acyl-[acyl-carrier-protein] desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01050">
        <property type="entry name" value="Acyl_ACP_Desat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005067">
        <property type="entry name" value="Fatty_acid_desaturase-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31155">
        <property type="entry name" value="PTHR31155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03405">
        <property type="entry name" value="FA_desaturase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000346">
        <property type="entry name" value="Dlt9_acylACP_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000346-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="338" mass="38770" checksum="9AC9B5A4FFBDAC20" modified="2021-06-02" version="1">MSAKLTDLQLLHELEPVVEKYLNRHLSMHKPWNPHDYIPWSDGKNYYALGGQDWDPDQSKLSDVAQVAMVQNLVTEDNLPSYHREIAMNMGMDGAWGQWVNRWTAEENRHGIALRDYLVVTRSVDPVELEKLRLEVVNRGFSPGQNHQGHYFAESLTDSVLYVSFQELATRISHRNTGKACNDPVADQLMAKISADENLHMIFYRDVSEAAFDLVPNQAMKSLHLILSHFQMPGFQVPEFRRKAVVIAVGGVYDPRIHLDEVVMPVLKKWRIFEREDFTGEGAKLRDELALVIKDLELACDKFEVSKQRQLDREARTGKKVSAHELHKTAGKLAMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFR8</accession>
    <name>A0A7U8TFR8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="300" mass="27702" checksum="3093122953DED8EE" modified="2021-06-02" version="1">MSYVLATPEMVAAAANNLAQIGSTLSAANAAALAPTTGVLAAGADEVSAAVASLFSGHAQAYQTLGTQAAAFHERFIQALSTAAGAYGSAEAANASPLQQALNVINAPTQTLLGRPLIGNGTNGAPGTGQAGGPGGLLYGNGGNGGSGGVGQAGGAGGSAGLIGIGGTGGAGGAGAVGGVGGNGGWLYGNGGAGGLGGTGVAGVNGGMGAAGGAGGNAYLFGSGGAGGQGGMGAAGADGVNPTPTGTADAGSTGTDQTLGGNAIGGNGGPGDAGDAMTSGRRWRVWRERRLNRQRRRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFS2</accession>
    <name>A0A7U8TFS2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin biosynthesis protein mog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404549.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFS2"/>
    <dbReference type="GeneID" id="45424831"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="7"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="160" mass="16188" checksum="4DD3AE6A0FE98E2D" modified="2021-06-02" version="1">MSTRSARIVVVSSRAAAGVYTDDCGPIIAGWLEQHGFSSVQPQVVADGNPVGEALHDAVNAGVDVIITSGGTGISPTDTTPEHTVAVLDYVIPGLADAIRRSGLPKVPTSVLSRGVCGVAGRTLIINLPGSPGGVRDGLGVLADVLDHALEQIAGGDHPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFS8</accession>
    <name>A0A7U8TFS8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404586.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019494">
        <property type="entry name" value="FIST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013702">
        <property type="entry name" value="FIST_domain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016741">
        <property type="entry name" value="UCP018953"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08495">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10442">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018953">
        <property type="entry name" value="UCP018953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00897">
        <property type="entry name" value="FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01204">
        <property type="entry name" value="FIST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FIST" evidence="7">
        <location>
            <begin position="33"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="FIST_C" evidence="8">
        <location>
            <begin position="221"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="386" mass="40402" checksum="6BA71B4ACDAA190C" modified="2021-06-02" version="1">MRIGVGVCTTPDARQAAVEAAGQARDELAGEAPSLAVLLGSRAHTDRAADVLSAVLQMIDPPALVGCIAQAIVAGRHEIEDEPAVVVWLASGLAAETFQLDFVRTGSGALITGYRFDRTARDLHLLLPDPYTFPSNLLIEHPNTDLPGTAVVGGVVSGGRRRGDTRLFRDHDVLTSGVVGVRLPGMRGVPVVSQGCRPIGYPYIVTGADGILITELGGRPPLQRLREIVEGLSPDERALVSHGLQIGIVVDEHLAAPGQGDFVIRGLLGADPSTGSIEIDEVVQVGATMQFQVRDAAGADKDLRLTVERAAARLPGRAAGALLFTCNGRGRRMFGVADHDASTIEELLGGIPLAGFFAAGEIGPIAGRNALHGFTASMALFVDDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFV3</accession>
    <name>A0A7U8TFV3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03028</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404591.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024495">
        <property type="entry name" value="DUF2771"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10969">
        <property type="entry name" value="DUF2771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="162" mass="17833" checksum="651EAA16B4FF5AD0" modified="2021-06-02" version="1">MKRGVATLPVILVILLSVAAGAGAWLLVRGHGPQQPEISAYSHGHLTRVGPYLYCNVVDLDDCQTPQAQGELPVSERYPVQLSVPEVISRAPWRLLQVYQDPANTTSTLFRPDTRLAVTIPTVDPQRGRLTGIVVQLLTLVVDHSGELRDVPHAEWSVRLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFZ9</accession>
    <name>A0A7U8TFZ9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="8">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="8">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="8">IMP cyclohydrolase</fullName>
                <ecNumber evidence="8">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="8">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="8">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="8" type="primary">purH</name>
        <name evidence="10" type="ORF">TBLG_03116</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="8"/>
    <dbReference type="EC" id="3.5.4.10" evidence="8"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404890.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFZ9"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MGS-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="523" mass="55026" checksum="5A78C034101019C7" modified="2021-06-02" version="1">MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQLTGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESGASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAALRAGGFTLAERKRLASLAFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPTAWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADAHRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRVLVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTLATGSPADPATLTDLVFAWRACRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLETLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG15</accession>
    <name>A0A7U8TG15_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase echA7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404949.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG15"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="269" mass="27604" checksum="802EA79381310880" modified="2021-06-02" version="1">MDSPVDYAGPAACGGPFARLTLNSPHNRNALSSTLVSQLHQGLSAAEADPAVRLVVLGHTGGTFCAGADLSEAGGGGGDPYRMAVARAREMTALLRAIVESPLPVVGAINGHVRAGGFGLVGACDMVVAGPESTFALTEARIGVAPAIISLTLLPKLSPRAAARYYLTGEKFGAREAADIGLITMAADDVDAAVAALVADVGRGSPQGLAASKALTTAAVLEGFDRDAERLTEESARLFVSDEAREGMLAFLQKRPPRWVQPATMRAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG18</accession>
    <name>A0A7U8TG18_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin carboxylase</fullName>
            <ecNumber evidence="2">6.3.4.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:13502"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="2"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="118"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="9">
        <location>
            <begin position="582"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="667" mass="70727" checksum="F763885F8FEF6B73" modified="2021-06-02" version="1">MGITRVLVANRGEIARRVFATCRRLGLGTVAVYTDPDAAAPHAAEADARVRLPQTTDYLNAEAIIAAAQAAGADAVHPGYGFLSENAEFAAAVQEAGLTWVGPPVDAVRAMGSKIESKKLMAAAGVPVLEELDPDAVTTAQLPVLVKASAGGGGRGMRVVHELSALPAEVEAARREAQSAFGDPTVFCERYLPTGHHVEVQVMADTHGTVWAVGERECSIQRRHQKIIEEAPSPLVERVPGMRAKLFDAARLAASAIGYTGAGTVEFLADDSPGREGEFYFLEMNTRLQVEHPVTEETTGLDLVELQLMIADCGRLDTEPPPAQGYSIEARLYAEDPAHGWQPQAGVMHTIEVPGVRAQFDSLGQRTGIRLDSGIVDGSTVSIHYDPMLAKVVSYGATRRQAALVLADALVRARLHGLRTNRELLVNVLRHPAFLDGATDTGFFDTHGMAELSTPLADTATLRLSAIAAALADAEHNRASAGVFSSIPSGWRNLASGYQVKTYRDDADTEHRVEYRFTRTGLALPGDPVVQLVSADVDQVVLAQDGVAHGFTVARHGPDVYVDSARGPVHLVALSRFPEPSSAVEQGSLVAPMPGNVIRIGAEVGDTVTAGQPLIWLEAMKMEHTIAAPADGVLTHVSVNTGQQVEVGAILARVEAPQNGPAEGDPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG30</accession>
    <name>A0A7U8TG30_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405150.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424967"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="83" mass="9167" checksum="884C0BFF547384D2" modified="2021-06-02" version="1">MSTKYYLQKVPVEAVQPGFSLAIPHDGDYRLFQVDCTQMCQRSGQPVMIRLMSESVDGGQPWVLEYEAGTAVIRLLGVCQAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG38</accession>
    <name>A0A7U8TG38_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="8">CMK</shortName>
            <ecNumber evidence="2 8">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">ispE</name>
        <name evidence="11" type="ORF">TBLG_03175</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="2 8"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG38"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP_kinases_N" evidence="9">
        <location>
            <begin position="91"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="10">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="306" mass="31382" checksum="98A513F46E487492" modified="2021-06-02" version="1">MPTGSVTVRVPGKVNLYLAVGDRREDGYHELTTVFHAVSLVDEVTVRNADVLSLELVGEGADQLPTDERNLAWQAAELMAEHVGRAPDVSIMIDKSIPVAGGMAGGSADAAAVLVAMNSLWELNVPRRDLRMLAARLGSDVPFALHGGTALGTGRGEELATVLSRNTFHWVLAFADSGLLTSAVYNELDRLREVGDPPRLGEPGPVLAALAAGDPDQLAPLLGNEMQAAAVSLDPALARALRAGVEAGALAGIVSGSGPTCAFLCTSASSAIDVGAQLSGAGVCRTVRVATGPVPGARVVSAPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG40</accession>
    <name>A0A7U8TG40_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="15">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="15">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="15">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="15">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="15">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">glmU</name>
        <name evidence="18" type="ORF">TBLG_03182</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="15"/>
    <dbReference type="EC" id="2.3.1.157" evidence="15"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405267.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG40"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01173">
        <property type="entry name" value="glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 15" id="KW-0133">Cell shape</keyword>
    <keyword evidence="14 15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 15 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="17">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="15">
        <location>
            <begin position="1"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="88"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="UDP-GlcNAc binding" evidence="15">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="15">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="263"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Acetyl-CoA binding" evidence="15">
        <location>
            <begin position="397"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="457"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EFD12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="495" mass="51584" checksum="C14DC76BD6E5EC86" modified="2021-06-02" version="1">MTFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQRLIVVLGHDHQRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALPDDYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYGRILRTQDHEVMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSSNNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNNRVQLAELASELNRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGRCVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPFTYLRPGTALGADGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNIGASSVFVNYDGTSKRRTTVGSHVRTGSDTMFVAPVTIGDGAYTGAGTVVREDVPPGALAVSAGPQRNIENWVQRKRPGSPAAQASKRASEMACQQPTQPPDADQTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG89</accession>
    <name>A0A7U8TG89_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="200" mass="18638" checksum="F3901008BCAAD4A1" modified="2021-06-02" version="1" fragment="single">MSYMIAVPDMLSSAAGDLASIGSSINASTRAAAAATTRLLPAAADEVSAHIAALFSGHGEGYQAIARQMAAFHDQFTLALTSSAGAYASAEATNVEQQVLGLINAPTQALWGRPLIGNGADGTAANPNGGAGGLLYGNGGNGFSQTTAGLTGGTGGSAGLIGNGGNGGAGGAGANGGAGGNGGWLYGSGGNGGAGGAGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGC9</accession>
    <name>A0A7U8TGC9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent protein deacylase</fullName>
            <ecNumber evidence="3">2.3.1.286</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Regulatory protein SIR2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cobB</name>
        <name evidence="5" type="ORF">TBLG_03326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:43636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="ChEBI" id="CHEBI:83767"/>
            <dbReference type="EC" id="2.3.1.286"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:47668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:11877"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:87830"/>
            <dbReference type="ChEBI" id="CHEBI:87832"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">2 residues (Tyr-53 and Arg-56) present in a large hydrophobic pocket are probably involved in substrate specificity. They are important for desuccinylation activity, but dispensable for deacetylation activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.286" evidence="3"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406044.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGC9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034979">
        <property type="term" value="F:NAD-dependent protein deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036054">
        <property type="term" value="F:protein-malonyllysine demalonylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036055">
        <property type="term" value="F:protein-succinyllysine desuccinylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006476">
        <property type="term" value="P:protein deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01412">
        <property type="entry name" value="SIRT5_Af1_CobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01121">
        <property type="entry name" value="Sirtuin_ClassIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027546">
        <property type="entry name" value="Sirtuin_class_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="177"/>
            <end position="179"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="237" mass="25661" checksum="0D826859B37AFFD7" modified="2021-06-02" version="1">MRVAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWLRNPERVWGWYLWRHYLVANVEPNDGHRAIAAWQDHAEVSVITQNVDDLHERAGSGAVHHLHGSLFEFRCARCGVPYTDALPEMPEPAIEVEPPVCDCGGLIRPDIVWFGEPLPEEPWRSAVEATGSADVMVVVGTSAIVYPAAGLPDLALARGTAVIEVNPEPTPLSGSATISIRESASQALPGLLERLPALLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGF0</accession>
    <name>A0A7U8TGF0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898751.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGF0"/>
    <dbReference type="GeneID" id="45425140"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022171">
        <property type="entry name" value="PPE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12484">
        <property type="entry name" value="PPE-SVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="6"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-SVP" evidence="3">
        <location>
            <begin position="270"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="346" mass="35821" checksum="6DC0844DA6EB9C68" modified="2021-06-02" version="1">MDFTIFPPEFNSLNIQGSARPFLVAANAWKNLSNELSYAASRFESEINGLITSWRGPSSTIMAAAVAPFRAWIVTTASLAELVADHISVVAGAYEAAHAAHVPLPVIETNRLTRLALATTNIFGIHTPAIFALDALYAQYWSQDGEAMNLYATMAAAAARLTPFSPPAPIANPGALARLYELIGSVSETVGSFAAPATKNLPSKLWTLLTKGTYPLTAARISSIPVEYVLAFVEGSNMGQMMGNLAMRSLTPTLKGPLELLPNAVRPAVSATLGNADTIGGLSVPPSWVADKSITPLAKAVPTSAPGGPSGTSWAQLGLASLAGGAVGAVAARTRSGVILRSPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGF5</accession>
    <name>A0A7U8TGF5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CdaR family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406219.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGF5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041522">
        <property type="entry name" value="CdaR_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025736">
        <property type="entry name" value="PucR_C-HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042070">
        <property type="entry name" value="PucR_C-HTH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17853">
        <property type="entry name" value="GGDEF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13556">
        <property type="entry name" value="HTH_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF_2" evidence="3">
        <location>
            <begin position="187"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_30" evidence="2">
        <location>
            <begin position="345"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="421" mass="46098" checksum="4D98DC493263F6FA" modified="2021-06-02" version="1">MAWQQPSPRIRELIREGARIALNPSPEWIEELDRATIAANPAIANDPVLAKVVQTANRANLVYWAAANLRDPGARVPANLGTEPLRMARDLVRRGLDTVAFNIYRTGEHIGWRFWMGIAFELTSDPQELRELLDVSARSVNDFIEATLTGIAAQVQSEHDELTRSTHAERLEVVGLILDGAPISPERAEAKLGYPLSRAHTAAIIWSDELDGDHSYLDRAADLFCHAVGSTRPLTVVAGAASRWAWVTDADGLDIDTVQAAVDNAPGARIAIGTTANGVEGFRRSHLEALITQRTLSRLRSTQRVAFFADVKMVALISQNPDAASEFITSTLGDLESASPDLQTALLTFINEQCNASRAAKRLHTHRNTFLRRLESAQRLLPRPLDHTSVHVAVALEALQWRGNKAHALSSPGRRSNSVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGG9</accession>
    <name>A0A7U8TGG9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003421604.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGG9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03930">
        <property type="entry name" value="WXG100_ESAT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="98" mass="10963" checksum="1FD04CAB64A779D1" modified="2021-06-02" version="1">MASRFMTDPHAMRDMAGRFEVHAQTVEDEARRMWASAQNISGAGWSGMAEATSLDTMAQMNQAFRNIVNMLHGVRDGLVRDANNYEQQEQASQQILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGH9</accession>
    <name>A0A7U8TGH9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGH9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006668">
        <property type="entry name" value="Mg_transptr_MgtE_intracell_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038076">
        <property type="entry name" value="MgtE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006669">
        <property type="entry name" value="MgtE_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43773">
        <property type="entry name" value="PTHR43773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03448">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00924">
        <property type="entry name" value="MgtE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="360"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="435" mass="47328" checksum="1EF4C03DB719DEC8" modified="2021-06-02" version="1">MGSVNRVYLARLSRMSVLGPLGESFGRVRDVVISISIVRQQPRVLGLVVDLATRRKIFIPILRVAAIEPHAVTLSTGNVSLHRFEQRPGEALALGQVLDTLVKVNDPALPELAGVDVVVTDLGVEQTRSRDWMVTRVAVRTQRRLRRRGPVHVVDWHNVAGLTPSALAMPGQDVAQLLDQFEGWKAVDVADAIRGLPPKRRHEVFKALHDKRLADVLQELPELDQAEVLSQLGTERAADVLEEMDPDDAADLLAVLNPTEAELLLTRMDPGDSGQVRRLLTHSPDTAGGLMTSDPVVLTPDTSIAEALARVRDPDLTPALASMVFVARPPTATPTGHYLGCVHLQRLLRDPPAELVGGVVDTDLLTLTPETPLAAVTRYFAAYNLVCGPVVDDENHLLGAVTVDDLLDHLLPHDWRVDMPELDPSGAPDRPGGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGI0</accession>
    <name>A0A7U8TGI0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406261.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGI0"/>
    <dbReference type="GeneID" id="45425195"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07509">
        <property type="entry name" value="HAD_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006355">
        <property type="entry name" value="LHPP/HDHD2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="276" mass="29121" checksum="7C6C98F9A5A1E522" modified="2021-06-02" version="1">MDVAHLMAAAVLFDIDGVLVLSWRAIPGAAETVRQLTHRGIACAYLTNTTTRTRRQIAEALGAAGIPVAADDVITAGVLTAEYLHGAYPGARCFLVNNGDITEDLPGIDVVLSTEIGPEDCPEAPDVVVLGSAGPQFDHRTLSRVYGWMLDGVPVVAMHRNMTWNTTDGLRIDTGMYLTGMEQACGKTATAIGKPAAEGFLAAADRVGVDPQQMVMIGDDLHNDVLAAQAVGMTGVLVRTGKFRQQTLDRWLAGASATRPHHVIDSVAGLPPLLGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGL4</accession>
    <name>A0A7U8TGL4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic oligopeptide-binding lipoprotein oppA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900310.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGL4"/>
    <dbReference type="GeneID" id="45425252"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="2">
        <location>
            <begin position="150"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="591" mass="63477" checksum="E63F417047BE91CE" modified="2021-06-02" version="1">MADRGQRRGCAPGIASALRASFQGKSRPWTQTRYWAFALLTPLVVAMVLTGCSASGTQLELAPTADRRAAVGTTSDINQQDPATLQDGGNLRLSLTDFPPNFNILHIDGNNAEVAAMMKATLPRAFIIGPDGSTTVDTNYFTSIELTRTAPQVVTYTINPEAVWSDGTPITWRDIASQIHAISGADKAFEIASSSGAERVASVTRGVDDRQAVVTFAKPYAEWRGMFAGNGMLLPASMTATPEAFNKGQLDGPGPSAGPFVVSALDRTAQRIVLTRNPRWWGARPRLDSITYLVLDDAARLPALQNNTIDATGVGTLDQLTIAARTKGISIRRAPGPSWYHFTLNGAPGSILADKALRLAIAKGIDRYTIARVAQYGLTSDPVPLNNHVFVAGQDGYQDNSGVVAYNPEQAKRELDALGWRRSGAFREKDGRQLVIRDLFYDAQSTRQFAQIAQHTLAQIGVKLELQAKSGSGFFSDYVNVGAFDIAQFGWVGDAFPLSSLTQIYASDGESNFGKIGSPQIDAAIERTLAELDPGKARALANQVDELIWAEGFSLPLTQSPGTVAVRSTLANFGATGLADLDYTAIGFMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGM2</accession>
    <name>A0A7U8TGM2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 17">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">TBLG_03476</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 17">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 17"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406648.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGM2"/>
    <dbReference type="GeneID" id="45425268"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14 17" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 17" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 17" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 16 17" id="KW-0521">NADP</keyword>
    <keyword evidence="12 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 17" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="19">
        <location>
            <begin position="356"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="13"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EFD12892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="441" mass="45553" checksum="818248C137885BE8" modified="2021-06-02" version="1">MPGDEKPVGVAVLGLGNVGSEVVRIIENSAEDLAARVGAPLVLRGIGVRRVTTDRGVPIELLTDDIEELVAREDVDIVVEVMGPVEPSRKAILGALERGKSVVTANKALLATSTGELAQAAESAHVDLYFEAAVAGAIPVIRPLTQSLAGDTVLRVAGIVNGTTNYILSAMDSTGADYASALADASALGYAEADPTADVEGYDAAAKAAILASIAFHTRVTADDVYREGITKVTPADFGSAHALGCTIKLLSICERITTDEGSQRVSARVYPALVPLSHPLAAVNGAFNAVVVEAEAAGRLMFYGQGAGGAPTASAVTGDLVMAARNRVLGSRGPRESKYAQLPVAPMGFIETRYYVSMNVADKPGVLSAVAAEFAKREVSIAEVRQEGVVDEGGRRVGARIVVVTHLATDAALSETVDALDDLDVVQGVSSVIRLEGTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGM7</accession>
    <name>A0A7U8TGM7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406616.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGM7"/>
    <dbReference type="GeneID" id="45425256"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="163" mass="18189" checksum="DDD342B7DBFE5AA0" modified="2021-06-02" version="1">MTVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGN2</accession>
    <name>A0A7U8TGN2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpmE</name>
        <name evidence="8" type="ORF">TBLG_03480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406668.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGN2"/>
    <dbReference type="GeneID" id="45425272"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="80" mass="8753" checksum="6CF25D51A31BB136" modified="2021-06-02" version="1">MKSDIHPAYEETTVVCGCGNTFQTRSTKPGGRIVVEVCSQCHPFYTGKQKILDSGGRVARFEKRYGKRKVGADKAVSTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGQ4</accession>
    <name>A0A7U8TGQ4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA acetyltransferase fadA4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGQ4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="267"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="389" mass="40081" checksum="32F892A90364AB05" modified="2021-06-02" version="1">MIVAGARTPIGKLMGSLKDFSASELGAIAIKGALEKANVPASLVEYVIMGQVLTAGAGQMPARQAAVAAGIGWDVPALTINKMCLSGIDAIALADQLIRAREFDVVVAGGQESMTKAPHLLMNSRSGYKYGDVTVLDHMAYDGLHDVFTDQPMGALTEQRNDVDMFTRSEQDEYAAASHQKAAAAWKDGVFADEVIPVNIPQRTGDPLQFTEDEGIRANTTAAALAGLKPAFRGDGTITAGSASQISDGAAAVVVMNQEKAQELGLTWLAEIGAHGVVAGPDSTLQSQPANAINKALDREGISVDQLDVVEINEAFAAVALASIRELGLNPQIVNVNGGAIAVGHPLGMSGTRITLHAALQLARRGSGVGVAALCGAGGQGDALILRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGR3</accession>
    <name>A0A7U8TGR3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Glutamate racemase</fullName>
            <ecNumber evidence="2 7">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">murI</name>
        <name evidence="8" type="ORF">TBLG_03523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="2 7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406919.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGR3"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="44"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="271" mass="28643" checksum="29DE3CE67A27EEBA" modified="2021-06-02" version="1">MNSPLAPVGVFDSGVGGLTVARAIIDQLPDEDIVYVGDTGNGPYGPLTIPEIRAHALAIGDDLVGRGVKALVIACNSASSACLRDARERYQVPVVEVILPAVRRAVAATRNGRIGVIGTRATITSHAYQDAFAAARDTEITAVACPRFVDFVERGVTSGRQVLGLAQGYLEPLQRAEVDTLVLGCTHYPLLSGLIQLAMGENVTLVSSAEETAKEVVRVLTEIDLLRPHDAPPATRIFEATGDPEAFTKLAARFLGPVLGGVQPVHPSRIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGS3</accession>
    <name>A0A7U8TGS3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03522</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898831.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425315"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="7">
        <location>
            <begin position="73"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="240" mass="25703" checksum="E43B682C8606CB69" modified="2021-06-02" version="1">MGMTPRRKRRGGAVQITRPTGRPRTPTTQTTKRPRWVVGGTTILTFVALLYLVELIDQLSGSRLDVNGIRPLKTDGLWGVIFAPLLHANWHHLMANTIPLLVLGFLMTLAGLSRFVWATAIIWILGGLGTWLIGNVGSSCGPTDHIGASGLIFGWLAFLLVFGLFVRKGWDIVIGLVVLFVYGGILLGAMPVLGQCGGVSWQGHLSGAVAGVVAAYLLSAPERKARALKRAGARSGHPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGS4</accession>
    <name>A0A7U8TGS4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_02759</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403236.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGS4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="4"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="131" mass="14250" checksum="777FCE0A5BB640E3" modified="2021-06-02" version="1">MVIDTSALVAMLSDEPDAERFEAAVEADHIRLMSTASYLETALVIEARFGEPGGRELDLWLHRAAVDLVAVHADQADAARAAYRTYGKGRHRAGLNYGDCFSYGLAKISGQPLLFKGEDFQHTDIATVALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGT6</accession>
    <name>A0A7U8TGT6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898845.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGT6"/>
    <dbReference type="GeneID" id="45425345"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="17"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="128" mass="13589" checksum="BB489351860A0005" modified="2021-06-02" version="1">MNPTQAGSFTTPVSNALKATIQHHDSAVIIHARGEIDAANEHTWQDLVTKAAAATTAPEPLVVNLNGLDFMGCCAVAVLAHEAERCRRRGVDVRLVSRDRAVARIIHACGYGDVLPVHPTTESALSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGT9</accession>
    <name>A0A7U8TGT9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_03585</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGT9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD13001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="133" mass="14894" checksum="853D7B9013EB2594" modified="2021-06-02" version="1">MILVDSDVLIAHLRGVVAARDWLVSARKDGPLAISVVSTAELIGGMRTAERREVWRLLASFRVQPATEVIARRAGDMMRRYRRSHNRIGLGDYLIAATADVQGLQLATLNVWHFPMFEQLKPPFAVPGHRPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGU2</accession>
    <name>A0A7U8TGU2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7 8">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplJ</name>
        <name evidence="9" type="ORF">TBLG_02789</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403341.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGU2"/>
    <dbReference type="GeneID" id="45424611"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="178" mass="18478" checksum="48CB571C1A9B801D" modified="2021-06-02" version="1">MARADKATAVADIAAQFKESTATLITEYRGLTVANLAELRRSLTGSATYAVAKNTLIKRAASEAGIEGLDELFVGPTAIAFVTGEPVDAAKAIKTFAKEHKALVIKGGYMDGHPLTVAEVERIADLESREVLLAKLAGAMKGNLAKAAGLFNAPASQLARLAAALQEKKACPGPDSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGU7</accession>
    <name>A0A7U8TGU7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpe</name>
        <name evidence="15" type="ORF">TBLG_03596</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901153.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGU7"/>
    <dbReference type="GeneID" id="45425386"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="203"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EFD13012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="232" mass="24105" checksum="1BF84D9D6F8FD325" modified="2021-06-02" version="1">MSLMAGSTGGPLIAPSILAADFARLADEAAAVNGADWLHVDVMDGHFVPNLTIGLPVVESLLAVTDIPMDCHLMIDNPDRWAPPYAEAGAYNVTFHAEATDNPVGVARDIRAAGAKAGISVKPGTPLEPYLDILPHFDTLLVMSVEPGFGGQRFIPEVLSKVRAVRKMVDAGELTILVEIDGGINDDTIEQAAEAGVDCFVAGSAVYGADDPAAAVAALRRQAGAASLHLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGY7</accession>
    <name>A0A7U8TGY7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsS</name>
        <name evidence="7" type="ORF">TBLG_02849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403584.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGY7"/>
    <dbReference type="GeneID" id="45424670"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="93" mass="10804" checksum="26F7D53D8D00B56E" modified="2021-06-02" version="1">MPRSLKKGPFVDEHLLKKVDVQNEKNTKQVIKTWSRRSTIIPDFIGHTFAVHDGRKHVPVFVTESMVGHKLGEFAPTRTFKGHIKDDRKSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH88</accession>
    <name>A0A7U8TH88_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein lpqS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901025.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424813"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031186500" evidence="1">
        <location>
            <begin position="22"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="130" mass="13519" checksum="CB443C14F32A27BD" modified="2021-06-02" version="1">MVWMRSAIVAVALGVTVAAVAAACWLPQLHRHVAHPNHPLTTSVGSEFVINTDHGHLVDNSMPPCPERLATAVLPRSATPVLLPDVVAAAPGMTAALTDPVAPAARGPPAAQGSVRTGQDLLTRFCLARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH90</accession>
    <name>A0A7U8TH90_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Neutral ceramidase</fullName>
            <ecNumber evidence="3">3.5.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acylsphing-4-enine + H2O = a fatty acid + sphing-4-enine</text>
            <dbReference type="Rhea" id="RHEA:20856"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="ChEBI" id="CHEBI:57756"/>
            <dbReference type="EC" id="3.5.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the neutral ceramidase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.23" evidence="3"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102121">
        <property type="term" value="F:ceramidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017040">
        <property type="term" value="F:N-acylsphingosine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006823">
        <property type="entry name" value="Ceramidase_alk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12670">
        <property type="entry name" value="PTHR12670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0746">Sphingolipid metabolism</keyword>
    <feature type="domain" description="Ceramidase_alk" evidence="4">
        <location>
            <begin position="3"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Ceramidse_alk_C" evidence="5">
        <location>
            <begin position="430"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="581" mass="63470" checksum="1A6ED2C9EC0040D1" modified="2021-06-02" version="1">MIVAELPLPMQNVNEEVLRRLADLYGDTYSEQNTLITATHTHAGPGGYCGYLLYNLTTSGFRPATFAAIVDGIVESVEHAHADVAPAEVSLSHGELYGASINRSPSAFDRNPPADKAFFPKRVDPHTTLVRIDRGEATVGVIHFFATHGTSMTNRNHLISGDNKGFAAYHWERTVGGADYLAGQPDFIAAFAQTNPGDMSPNVDGPLSPEAPPDREFDNTRRTGLCQFEDAFTQLSGATPIGAGIDARFTYVDLGSVLVRGEYTPDGEERRTGRPMFGAGAMAGTDEGPGFHGFRQGRNPFWDRLSRAMYRLARPTAAAQAPKGIVMPARLPNRIHPFVQEIVPVQLVRIGRLYLIGIPGEPTIVAGLRLRRMVASIVGADLADVLCVGYTNAYIHYVTTPEEYLEQRYEGGSTLFGRWELCALMQTVAELAEAMRDGRPVTLGRRPRPTRELSWVRGAPADAGSFGAVIAEPSATYRPGQAVEAVFVSALPNNDLRRGGTYLEVVRREGASWVRIADDGDWATSFRWQRQGRAGSHVSIRWDVPGDTTPGQYRIVHHGTARDRNGMLTAFSATTREFTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THA0</accession>
    <name>A0A7U8THA0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THA0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="93" mass="10111" checksum="1D4F18CB54E2733E" modified="2021-06-02" version="1">MCSVIADQRRPDQPCGVGGCKTCQNGFVADIAEGKARKTRYVDHGWPTTDPDDHAVSELVTDRTGALSPFGELTFPVPSDDLPYIHPVTVINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THD2</accession>
    <name>A0A7U8THD2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase echA6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03059</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404702.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THD2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="243" mass="26029" checksum="23BD1153F0159991" modified="2021-06-02" version="1">MIGITQAEAVLTIELQRPERRNALNSQLVEELTQAIRKAGDGSARAIVLTGQGTAFCAGADLSGDAFAADYPDRLIELHKAMDASPMPVVGAINGPAIGAGLQLAMQCDLRVVAPDAFFQFPTSKYGLALDNWSIRRLSSLVGHGRARAMLLSAEKLTAEIALHTGMANRIGTLADAQAWAAEIARLAPLAIQHAKRVLNDDGAIEEAWPAHKELFDKAWGSQDVIEAQVARMEKRPPKFQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THU7</accession>
    <name>A0A7U8THU7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03091</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THU7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="22"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="276" mass="29996" checksum="F52045DD1EF9580B" modified="2021-06-02" version="1">MACERLGGQSGAADVDAAAPAMAAVNLTLGFAGKTVLDQVSMGFPARAVTSLMGPTGSGKTTFLRTLNRMNDKVSGYRYSGDVLLGGRSIFNYRDVLEFRRRVGMLFQRPNPFPMSIMDNVLAGVRAHKLVPRKEFRGVAQARLTEVGLWDAVKDRLSDSPFRLSGGQQQLLCLARTLAVNPEVLLLDEPTSALDPTTTEKIEEFIRSLADRLTVIIVTHNLAQAARISDRAALFFDGRLVEEGPTEQLFSSPKHAETARYVAGLSGDVKDAKRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THX1</accession>
    <name>A0A7U8THX1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ESAT-6-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WXG100 family. ESAT-6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THX1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009416">
        <property type="entry name" value="ESAT-6-like_Myco"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037656">
        <property type="entry name" value="DUF1066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="94" mass="9972" checksum="A085B5BB923E746A" modified="2021-06-02" version="1">MTINYQFGDVDDHGAMIRAQAGLLEAEHQAIIRDVLTASDFWGGAGSAACQGFITQLGRNFQVIYEQANAHGQKVQAAGNNMAQTDSAVGSSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THZ3</accession>
    <name>A0A7U8THZ3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_03419</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406304.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THZ3"/>
    <dbReference type="GeneID" id="45425212"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006226">
        <property type="entry name" value="Mtu_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00028">
        <property type="entry name" value="Mtu_PIN_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="143" mass="15905" checksum="A22B4EE4B6E5371F" modified="2021-06-02" version="1">MIIPDINLLLYAVITGFPQHRRAHAWWQDTVNGHTRIGLTYPALFGFLRIATSARVLAAPLPTADAIAYVREWLSQPNVDLLTAGPRHLDIALGLLDKLGTASHLTTDVQLAAYGIEYDAEIHSSDTDFARFADLKWTDPLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THZ8</accession>
    <name>A0A7U8THZ8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.370.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023374">
        <property type="entry name" value="AttH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010791">
        <property type="entry name" value="AttH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07143">
        <property type="entry name" value="CrtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CrtC" evidence="1">
        <location>
            <begin position="71"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="386" mass="42790" checksum="888C4A3527F19C5A" modified="2021-06-02" version="1">MRKAGLTGVVLVLTLTLVAFWWWQRPRTNAVAADSLVGVLVDENNAGYSLATVPGAIRFPRDLGPHYDYQTEWWYYTGNLETADGRLFGYQLTFFRRALAPPGEGVAIADASSWRTTQVYMAHFAISDISNRGFYPAEKFSRQALGLAGASSEPYAVWLDDWYARESNNNSVQLFARTQNTVLDLTLTQTLPPILQGNAGLSVKGAQPGNASNYYSLVRQESRGTVSVNGDTFMVSGLSWKDHEYMTSALAPEDVGWDWFGLQFYNGTALMLFQIRQADGSVTRFSSGTFVAGDGGVIPLESSDFRIKTTDRWTSDQSGATYPIAWEIEIERIGLTLRGAALMANQELRLSRTYWEGAVALEGRYQGMPISGRGYVEMTGYVQRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI22</accession>
    <name>A0A7U8TI22_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="14">K+-transporting ATPase, B subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03196</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="611"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="682" mass="71940" checksum="1D481A2BD863D1AB" modified="2021-06-02" version="1" fragment="single">MMIARMETSATAAAATSAPRLRLAKRSLFDPMIVRSALPQSLRKLAPRVQARNPVMLVVLVGAVITTLAFLRDLASSTAQENVFNGLVAAFLWFTVLFANFAEAMAEGRGKAQAAALRKVRSETMANRRTAAGNIESVPSSRLDLDDVVEISAGETIPSDGEIIEGIASVDESAITGESAPVIRESGGDRSAVTGGTVVLSDRIVVRITAKQGQTFIDRMIALVEGAARQQTPNEIALNILLAGLTIIFLLAVVTLQPFAIYSGGGQRVVVLVALLVCLIPTTIGALLSAIGIAGMDRLVQHNVLATSGRAVEAAGDVNTLLLDKTGTITLGNRQATEFVPINGVSAEAVADAAQLSSLADETPEGRSIVVLAKDEFGLRARDEGVMSHARFVPFTAETRMSGVDLAEVSGIRRIRKGAAAAVMKWVRDHGGHPTEEVGAIVDGISSGGGTPLVVAEWTDNSSARAIGVVHLKDIVKVGIRERFDEMRRMSIRTVMITGDNPATAKAIAQEAGVDDFLAEATPEDKLALIKREQQGGRLVAMTGDGTNDAPALAQADVGVAMNTGTQAAREAGNMVDLDSDPTKLIEVVEIGKQLLITRGALTTFSIANDVAKYFAIIPAMFVGLYPVLDKLNVMALHSPRSAILSAVIFNALVIVALIPLALRGVRFRAESASAMLRRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIF5</accession>
    <name>A0A7U8TIF5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein lprB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024520">
        <property type="entry name" value="DUF3558"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12079">
        <property type="entry name" value="DUF3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030844308" evidence="2">
        <location>
            <begin position="26"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="185" mass="19723" checksum="B406D78748229453" modified="2021-06-02" version="1">MRRKVRRLTLAVSALVALFPAVAGCSDSGDNKPGATIPSTPANAEGRHGPFFPQCGGVSDQTVTELTRVTGLVNTAKNSVGCQWLAGGGILGPHFSFSWYRGSPIGRERKTEELSRASVEDINIDGHSGFIAIGNEPSLGDSLCEVGIQFSDDFIEWSVSFSQKPFPPPCDIAKELTRQSIANSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIH5</accession>
    <name>A0A7U8TIH5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein lprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LppX/LprAFG lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406562.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIH5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16334">
        <property type="entry name" value="LppX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009830">
        <property type="entry name" value="LppX/LprAFG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07161">
        <property type="entry name" value="LppX_LprAFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031505639" evidence="4">
        <location>
            <begin position="35"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="244" mass="24874" checksum="566C3A1459622BD8" modified="2021-06-02" version="1">MKHPPCSVVAAATAILAVVLAIGGCSTEGDAGKASDTAATASNGDAAMLLKQATDAMRKVTGMHVRLAVTGDVPNLRVTKLEGDISNTPQTVATGSATLLVGNKSEDAKFVYVDGHLYSDLGQPGTYTDFGNGASIYNVSVLLDPNKGLANLLANLKDASVAGSQQADGVATTKITGNSSADDIATLAGSRLTSEDVKTVPTTVWIASDGSSHLVQIQIAPTKDTSVTLTMSDWGKQVTATKPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIK1</accession>
    <name>A0A7U8TIK1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407052.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIK1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="250" mass="26886" checksum="702AD33E86F081A7" modified="2021-06-02" version="1">MFMALRAPMLERMNGLHTDDAPVNWLERRGGRLTSRRRVTLLHAGVEHPMRLWGVQSEAITAAMVLSRKVSAIIAGHCGVRLVDQGVGDGFVAAFAHASDAVACALELHQAPLSPIVLRIGIHTGEAQLVDERIYAGATMNLAAELRDLAHGGQTVMSGATEDAVLGRLPMRAWLIGLRPMEGSPEGHNFPQSQRIAQLCHPNLRNTFPPLRMRIADASGIPYVGRILVNVQVVPHWEGGCAAAGMVLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIT7</accession>
    <name>A0A7U8TIT7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ala_racemase_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIT7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="1">
        <location>
            <begin position="29"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="171" mass="17640" checksum="EA6E2590C6CE0E1F" modified="2021-06-02" version="1">MATIGEVEVFVDHGADDVFITYPLWIGTRQADRLRQLADRARIAVGAGTAEGASNTGARLADAAGAIDVLIEIDSGHHRSGVRAEQVLEVAHAVGEAGLHLVGVFTFPGHSYAPGKPGEAGEQERRALNDAANALVAVGFPISCRSGGSTPTALLTAADGASETSRRLCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR59</accession>
    <name>A0A7U8TR59_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416094.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR59"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022526">
        <property type="entry name" value="F420_Rv3093c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03841">
        <property type="entry name" value="F420_Rv3093c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="334" mass="34649" checksum="3F68AEC05BAB5958" modified="2021-06-02" version="1">MTDIEVALPFWLDRPDHEATDVALAAADTGFAALWIGEMATYDAFALATSIGLRTPNMTLKVGPLAVGVRGPVGLALGVSSVASLTGCRVDLALGASSPAIVAGWHGRPWAHHVPVMRETIECLRSIFTGARVEYSGRHVNSRGFRLRGAAPDTRIALGAFGPGMIRLAAQHADEVVLNLASPFRVGRVRAAIDSAAAAAGRAAPRLTVWVPVAVNPGAAAHSQLAAQLAVYLAPPGYGEMFSALGFDGLVRSARSRATRRELAVAVPSELLDRVCALGSPDRVAARLRAYADAGADCVAVVPATAEDPGGRVALRALRPGGLYGTAGDNDGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR94</accession>
    <name>A0A7U8TR94_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH quinone oxidoreductase fadB4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416403.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR94"/>
    <dbReference type="GeneID" id="45427128"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="7"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="323" mass="33853" checksum="5AEC3AEA01544C67" modified="2021-06-02" version="1">MRAVRVTRLEGPDAVEVAEVEEPTSAGVVIEVHAAGVAFPDALLTRGRYQYRPEPPFVLGAEIAGVVRSAPDNSQVRSGDRVVGLTMLTGGMAEVAVLSPERVFKLPDNMTFEAGAGVLFNDLTVYFALAVRGRLQAGETVLVHGAAGGIGTSTLRLAPALGASRTVAVVSTQEKAELATVAGATDVVLAEGFKDAVQELTNGRGVDIVVDPVGGDRFTDSLRSLAAGGRLLVIGFTGGEIPTVKVNRLLLNNIDVVGVGWGAWSLTHPDALAQQWSQLERLLRSGKLPPPEPVVYPLDQAAAAIASLENRTAKGKVVLRVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR99</accession>
    <name>A0A7U8TR99_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase subunit I M nuoM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416460.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR99"/>
    <dbReference type="GeneID" id="45427144"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="6">
        <location>
            <begin position="160"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="527"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="553" mass="59207" checksum="E50510EEECBCC0DB" modified="2021-06-02" version="1">MNNVPWLSVLWLVPLAGAVLIILLPPGRRRLAKWAGMVVSVLTLAVSIVVAAEFKPSAEPYQFVEKHSWIPAFGAGYTLGVDGIAVVLVLLTTVLIPLLLVAGWNDATDADDLSPASGRYPQRPAPPRLRSSGGERTRGVHAYVALTLAIESMVLMSVIALDVLLFYVFFEAMLIPMYFLIGGFGQGAGRSRAAVKFLLYNLFGGLIMLAAVIGLYVVTAQYDSGTFDFREIVAGVAAGRYGADPAVFKALFLGFMFAFAIKAPLWPFHRWLPDAAVESTPATAVLMMAVMDKVGTFGMLRYCLQLFPDPSTYFRPLIVTLAIIGVIYGAIVAIGQTDMMRLIAYTSISHFGFIIAGIFVMTTQGQSGSTLYMLNHGLSTAAVFLIAGFLIARRGSRSIADYGGVQKVAPILAGTFMVSAMATVSLPGLAPFISEFLVLLGTFSRYWLAAAFGVTALVLSAVYMLWLYQRVMTGPVAEGNERIGDLVGREMIVVAPLIALLLVLGVYPKPVLDIINPAVENTMTTIGQHDPAPSVAHPVPAVGASRTAEGPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRD1</accession>
    <name>A0A7U8TRD1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, tetR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16859">
        <property type="entry name" value="TetR_C_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="20"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="208" mass="22126" checksum="80981D7724F180FD" modified="2021-06-02" version="1">MKADLPSLDKAPGAGRQRDPRIDSAILSATAELLVQIGYSNLSLAAVAERAGTTKSALYRRWSSKAELVHEAAFPAAPTALQAAAGDIAADIRMMIAATRDVFTTPVVRAALPGLVADMTADAELNARVLARFADLFAAVRMRLREAVDRGEAHPDVDPDRLIELIGGATMLRMLLYPDDMLDDAWVDQTTAIVVRGVHRAAPGGSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRE7</accession>
    <name>A0A7U8TRE7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03831</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003907005.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="69" mass="7080" checksum="8DC4A466E8B3D9A3" modified="2021-06-02" version="1">MAAVVGGGPQDEIPEADAVEQGRAVDFDDEAGLDTAYLSGGAGDRDASEADVVDQAFVVPVADDEEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRK4</accession>
    <name>A0A7U8TRK4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416916.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="5">
        <location>
            <begin position="99"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="4">
        <location>
            <begin position="118"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="330" mass="34876" checksum="E3FACF709E67E860" modified="2021-06-02" version="1">MRPGDYDESDVKVRSGRSSRPRTKTRPEHADAEAAMVVSVDRGRWGCVLGGRPDRRITAMRARELGRTPIVVGDDVDVVGDLSGRPDTLARIVRRAPRRTVLRRTADDTDPTERVVVANADQLLIVVALADPPPRTGLVDRALIAAYAGGLTPILCLTKTDLAPAEPFGKQFADLELTVTAAGVDDPLLAVADLLAGKITVLLGHSGVGKSTLVNRLVPEADRAVGEVTEIGRGRHTSTRSVALPLGDTLSGSGWVIDTPGIRSFGLAHIQPDNVLLAFSDLAEATRECPRGCGHMGPPADPECALDTLSGPAARRAAAARRLLAVLSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRL3</accession>
    <name>A0A7U8TRL3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gmad1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gmad1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="136" mass="13937" checksum="2AD048D26CB5FCC8" modified="2021-06-02" version="1">MSRDGTRAAMVIGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRTDAAHPVSYVNLDGVNSDAPSRGLQTPLTAIAANPSTVYVAGPQGVLMYSASVESRPGWADVPGLMVPGAAPVLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRL5</accession>
    <name>A0A7U8TRL5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900000.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032716">
        <property type="entry name" value="ACC_epsilon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13822">
        <property type="entry name" value="ACC_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="156" mass="16887" checksum="F29C13C3973655F0" modified="2021-06-02" version="1">MGTCPCESSERNEPVSRVSGTNEVSDGNETNNPAEVSDGNETNNPAEVSDGNETNNPAPVSRVSGTNEVSDGNETNNPAPVTEKPLHPHEPHIEILRGQPTDQELAALIAVLGSISGSTPPAQPEPTRWGLPVDQLRYPVFSWQRITLQEMTHMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN5</accession>
    <name>A0A7U8TRN5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="5"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="94" mass="10221" checksum="E06FDF5385053B69" modified="2021-06-02" version="1" fragment="single">MSFIFTTPQALDNAAKSVSGIHDLWLADSKTAITVVNAIVPPAADPVSNRMVGRILEHMAQYQQISSQALEYLRGFSQGLAENAEAYRLAEAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRS0</accession>
    <name>A0A7U8TRS0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030808425" description="DUF732 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="36"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="129" mass="12988" checksum="3268B8329FF35312" modified="2021-06-02" version="1">MNLRRHQTLTLRLLAASAGILSAAAFAAPAQANPVDDAFIAALNNAGVNYGDPVDAKALGQSVCPILAEPGGSFNTAVASVVARAQGMSQDMAQTFTSIAISMYCPSVMADVASGNLPALPDMPGLPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRT5</accession>
    <name>A0A7U8TRT5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417767.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRT5"/>
    <dbReference type="GeneID" id="45427360"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13599">
        <property type="entry name" value="Pentapeptide_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="183" mass="20020" checksum="D4830FF752235A69" modified="2021-06-02" version="1">MQQWVDCEFTGRDFRDEDLSRLHTERAMFSECDFSGVNLAESQHRGSAFRNCTFERTTLWHSTFAQCSMLGSVFVACRLRPLTLDDVDFTLAVLGGNDLRGLNLTGCRLRETSLVDTDLRKCVLRGADLSGARTTGARLDDADLRGATVDPVLWRTASLVGARVDVDQAVAFAAAHGLCLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRW7</accession>
    <name>A0A7U8TRW7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 7">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_04086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + L-glutamate = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 7"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006536">
        <property type="term" value="P:glutamate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="PTHR43321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="440" mass="48663" checksum="5B2989B6F272CF5F" modified="2021-06-02" version="1">MFTAPVPALRMPDESMDPEAAYRFIHDELMLDGSSRLNLATFVTTWMDPEAEKLMAETFDKNMIDKDEYPATAAIEARCVSMVADLFHAEGLRDHDPTSATGVSTIGSSEAVMLGGLALKWRWRQRVGSWKGRMPNLVMGSNVQVVWEKFCRYFDVEPRYLPMERGRYVITPEQVLAAVDENTIGVVAILGTTYTGELEPIAETCAALDKLAAGGGVDVPVHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLTYPGVGFVVWRGPEHLPEDLVFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRLGRDGYTKVMQALSHTARWLGDQLREVDHCEVISDGSAIPVVSFRLAGDRGYTEFDVSHELRTFGWQVPAYTMPDNATDVAVLRIVVREGLSADLARALHDDAVTALAALDKVKPGGHFDAQHFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRX4</accession>
    <name>A0A7U8TRX4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpsK</name>
        <name evidence="10" type="ORF">TBLG_04112</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900064.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRX4"/>
    <dbReference type="GeneID" id="45427448"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD15218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="139" mass="14785" checksum="BD54A1C494AA323B" modified="2021-06-02" version="1">MPPAKKGPATSARKGQKTRRREKKNVPHGAAHIKSTFNNTIVTITDPQGNVIAWASSGHVGFKGSRKSTPFAAQLAAENAARKAQDHGVRKVDVFVKGPGSGRETAIRSLQAAGLEVGAISDVTPQPHNGVRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSS3</accession>
    <name>A0A7U8TSS3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416097.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TSS3"/>
    <dbReference type="GeneID" id="45427090"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013107">
        <property type="entry name" value="Acyl-CoA_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08028">
        <property type="entry name" value="Acyl-CoA_dh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_2" evidence="2">
        <location>
            <begin position="223"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="376" mass="40329" checksum="2CADF2D5BA14783D" modified="2021-06-02" version="1">MNQSETEIEILAEKIARWARARSAEIERDRRLPDELVTRLREAGLLRATMPREVAAPELAPGRALRCAEAVARGDASAGWCVSIAITSALLVAYLPARSREEMFGGGRGVAAGVWAPRGTARSVDGGVVVSGRWPFCSGINHADIMFAGCFVDDRQVPSVVALNKDELQVLDTWHTLGLRGTGSHDCVADDVFVPADRVFSVFDGPIVDRPLYRFPVFGFFALSIGAAALGNARAAIDDLVELAGGKKGLGSTRTLAERSATQAAAATAESALGAARALFYEVIEAAWQVSHDAEAVPVTMRNRLRLAATHAVRTSADVVRSMYDLAGGTAIYDNAPLQRRFRDAFTATAHFQVNEASRELPGRVLLDQPADVSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSU5</accession>
    <name>A0A7U8TSU5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901547.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="164" mass="18041" checksum="3DBD41F812E7BA03" modified="2021-06-02" version="1">MRSRSVRWDPRCRPGRSGVGDPHCDDPAGLLAAGAAAGRRHRAPGPAHRLRARALRVVRRLPRQEPRYRAGPGPVAPRLLPLPHLRAWDGAPWIWNLATAILPEATPIVDLYHARQHVHDLAGQLAPALGEHHSDWLTARLVDLDSGDIETLVQQPIGQHTGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT13</accession>
    <name>A0A7U8TT13_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013402">
        <property type="entry name" value="CHP02569"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02569">
        <property type="entry name" value="TIGR02569_actnb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="292" mass="31368" checksum="40C68F217093C688" modified="2021-06-02" version="1">MGSTRLTGVNVEPPPEHVLVAFGLAGAQPILLGAGWEGGWRCGEVVLSMVADNARAAWSARVRETLFVDGVRLARPVRSTDGRYVVSGWRADTFVAGAPEPRHDEVVSAAVRLHEATGKLERPRFLTQGPAAPWAEIDVFVAADRAGWEERPLQSVPPGVPTAPPAADPQRSIDLINQLAGLRKPTKSPNQLVHGDLYGTVLFAGTAPPGITDITPYWRPASWAAGVAVVDALSWGASDDGLIERWNALPEWPQMLLRALMFRLAVYALHPRSTAEAFPGLAHTAALVRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTE5</accession>
    <name>A0A7U8TTE5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalose 6-phosphate phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_04029</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Removes the phosphate from trehalose 6-phosphate to produce free trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-trehalose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23420"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58429"/>
            <dbReference type="EC" id="3.1.3.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trehalose phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.12" evidence="4"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417892.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTE5"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044651">
        <property type="entry name" value="OTSB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43768">
        <property type="entry name" value="PTHR43768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="391" mass="41720" checksum="87AAC490926F9187" modified="2021-06-02" version="1">MRKLGPVTIDPRRHDAVLFDTTLDATQELVRQLQEVGVGTGVFGSGLDVPIVAAGRLAVRPGRCVVVSAHSAGVTAARESGFALIIGVDRTGCRDALRRDGADTVVTDLSEVSVRTGDRRMSQLPDALQALGLADGLVARQPAVFFDFDGTLSDIVEDPDAAWLAPGALEALQKLAARCPIAVLSGRDLADVTQRVGLPGIWYAGSHGFELTAPDGTHHQNDAAAAAIPVLKQAAAELRQQLGPFPGVVVEHKRFGVAVHYRNAARDRVGEVAAAVRTAEQRHALRVTTGREVIELRPDVDWDKGKTLLWVLDHLPHSGSAPLVPIYLGDDITDEDAFDVVGPHGVPIVVRHTDDGDRATAALFALDSPARVAEFTDRLARQLREAPLRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTK5</accession>
    <name>A0A7U8TTK5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase fadE23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899936.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTK5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="6">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="5">
        <location>
            <begin position="241"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="401" mass="43344" checksum="B7FE4E6F00E4193C" modified="2021-06-02" version="1">MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEVGKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTN1</accession>
    <name>A0A7U8TTN1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMP dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418005.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTN1"/>
    <dbReference type="GeneID" id="45427406"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005992">
        <property type="entry name" value="IMP_DH-rel2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF85">
        <property type="entry name" value="PTHR11911:SF85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01304">
        <property type="entry name" value="IMP_DH_rel_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMPDH" evidence="2">
        <location>
            <begin position="17"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="375" mass="38991" checksum="221116AC214D9741" modified="2021-06-02" version="1">MVEIGMGRTARRTYELSEISIVPSRRTRSSKDVSTAWQLDAYRFEIPVVAHPTDALVSPEFAIELGRLGGLGVLNGEGLIGRHLDVEAKIAQLLEAAAADPEPSTAIRLLQELHAAPLNPDLLGAAVARIREAGVTTAVRVSPQNAQWLTPVLVAAGIDLLVIQGTIVSAERVASDGEPLNLKTFISELDIPVVAGGVLDHRTALHLMRTGAAGVIVGYGSTQGVTTTDEVLGISVPMATAIADAAAARRDYLDETGGRYVHVLADGDIHTSGELAKAIACGADAVVLGTPLAESAEALGEGWFWPAAAAHPSLPRGALLQIAVGERPPLARVLGGPSDDPFGGLNLVGGLRRSMAKAGYCDLKEFQKVGLTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TU07</accession>
    <name>A0A7U8TU07_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="72" mass="7984" checksum="97111CC9D13285ED" modified="2021-06-02" version="1">MARRSILMLDLVELLTHWHAGRSQVRLSESLGIDRKTVRKYTAPAIAAGIEPGGEPLSAEQWAELIGGWFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TU16</accession>
    <name>A0A7U8TU16_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RsdA_SigD_bd domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03986</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031928">
        <property type="entry name" value="RsdA_SigD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16751">
        <property type="entry name" value="RsdA_SigD_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="RsdA_SigD_bd" evidence="2">
        <location>
            <begin position="16"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="178" mass="19193" checksum="0D97E13501819C79" modified="2021-06-02" version="1" fragment="single">MTMREFGNPLGDRPPLDELARTDLLLDALAEREEVDFADPRDDALAALLGQWRDDLRWPPASALVSQDEAVAALRAGVAQRRRARRSLAAVGSVAAALLVLSGFGAVVADARPGDLLYGLHAMMFNRSRVSDDQIVLSAKANLAKVEQMIAQGQWAEAQDELAEVSSTVQAVTDGSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y245</accession>
    <name>A0A7U8Y245_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, tetR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02823</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403451.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y245"/>
    <dbReference type="GeneID" id="45424643"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="196" mass="21262" checksum="21541B187EF0DF17" modified="2021-06-02" version="1">MARPAKLSRESIVEGALTFLDREGWDSLTINALATQLGTKGPSLYNHVDSLEDLRRAVRIRVIDDIITMLNRVGAGRARDDAVLVMAGAYRSYAHHHPGRYSAFTRMPLGGDDPEYTAATRGAAAPVIAVLSSYGLDGEQAFYAALEFWSALHGFVLLEMTGVMDDIDTDAVFTDMVLRLAAGMERRTTHGGTAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2G0</accession>
    <name>A0A7U8Y2G0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="109" mass="11844" checksum="4B132FED6B3344FE" modified="2021-06-02" version="1">MGRRGNRRVHVDRVRLTGTERELRAENQSPPIFRPQNTLGDGANGLPLAVCTTTAHTCHTSHTHPSRWTPNPVPATKGVPAGLVQATFIIENLDPGNNDTPTPLHPNCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2G9</accession>
    <name>A0A7U8Y2G9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Medium chain fatty-acid-CoA ligase fadD14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405625.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2G9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="27"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="543" mass="59625" checksum="4FE5EA380E6E2132" modified="2021-06-02" version="1">MYGTMQDFPLTITAIMRHGCGVHGRRTVTTATGEGYRHSSYRDVGQRAGQLANALRRLGVTGDQRVATFMWNNTEHLVTYFAVPSMGAVLHTLNIRLFPEQIAYVTNEAEDRVILVDLSLARLLAPVLPKLDTVHTVIAVGEGDTTPLREAGKTVLRFAELIDAESPDFGWPQIDENSAAAMCYTSGTTGNPKGVVYSHRSSFLHTMAACTTNGIGVGSSDKVLPIVPMFHANGWGLPYAALMAGADLVLPDRHLDARSLIHMVETLKPTLAGAVPTIWNDVMHYLEKDPDHDMSSLRLVACGGSAVPESLMRTFEDKHDVQIRQLWGMTETSPLATMAWPPPGTPDDQHWAFRITQGQPVCGVETRIVDDDGQVLPNDGNAVGEVEVRGPWIAGSYYGGRDESKFDSGWLRTGDVGRIDEQGFITLTDRAKDVIKSGGEWISSVELENCLIAHPDVLEAAVVGVPDERWQERPLAVVVVREGATVSAGDLRAFLADKVVRWWLPERWAFVDEIPRTSVGKYDKKAIRSRYAEGAYQITEVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2K1</accession>
    <name>A0A7U8Y2K1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable M18 family aminopeptidase 2</fullName>
            <ecNumber evidence="9">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">apeB</name>
        <name evidence="12" type="ORF">TBLG_02946</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the peptidase M18 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="9"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404103.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2K1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00467">
        <property type="entry name" value="Aminopeptidase_M18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022984">
        <property type="entry name" value="M18_aminopeptidase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="PTHR28570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 10" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="433" mass="46056" checksum="228424208638F68C" modified="2021-06-02" version="1">MAATAHGLCEFIDASPSPFHVCATVAGRLLGAGYRELREADRWPDKPGRYFTVRAGSLVAWNAEQSGHTQVPFRIVGAHTDSPNLRVKQHPDRLVAGWHVVALQPYGGVWLHSWLDRDLGISGRLSVRDGTGVSHRLVRIDDPILRVPQLAIHLAEDRKSLTLDPQRHINAVWGVGERVESFVGYVAQRAGVAAADVLAADLMTHDLTPSALIGASVNGTASLLSAPRLDNQASCYAGMEALLAVDVDSASSGFVPVLAIFDHEEVGSASGHGAQSDLLSSVLERIVLAAGGTREDFLRRLTTSMLASADMAHATHPNYPDRHEPSHPIEVNAGPVLKVHPNLRYATDGRTAAAFALACQRAGVPMQRYEHRADLPCGSTIGPLAAARTGIPTVDVGAAQLAMHSARELMGAHDVAAYSAALQAFLSAELSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2N5</accession>
    <name>A0A7U8Y2N5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltranfer_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404373.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2N5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="40"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="270" mass="29640" checksum="C443965D41FE31A6" modified="2021-06-02" version="1">MNDKRRAIYTHGYHESVLRSHRRRTAENSAGYLLPYLVPGLSVLDVGCGPGTITVDLAARVVPGSVTGVEPTDDALSLARAEAQLHRLSNISFTTSDVHKLDFPDDAFDVVHAHQVLQHVADPVRALQEMRRVCTPGGIVAARDADYSGFIWFPKLPALDRWLDLYERAARANGGEPDAGRRLLSWARAAGFDDVTPTASVWCFATASAREWWGLVWADRILQSDLAHQLVDSGLATAAQLEEISTAWREWAAAPDGWLAIPHGEILCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2U3</accession>
    <name>A0A7U8Y2U3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404673.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2U3"/>
    <dbReference type="GeneID" id="45424861"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020311">
        <property type="entry name" value="Uncharacterised_Rv0898c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10944">
        <property type="entry name" value="DUF2630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="87" mass="9920" checksum="79D055AB95C09BB2" modified="2021-06-02" version="1">MGKGRKPTDSETLAHIRDLVAEEKALRAQLRHGGISESEEQQQLRRIEIELDQCWDLLRQRRALRQTGGDPREAVVRPADQVEGYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2U8</accession>
    <name>A0A7U8Y2U8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404738.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424875"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="149" mass="15438" checksum="5A521D653C5530FD" modified="2021-06-02" version="1">MTRRLRPGWLVALSAAVIAASTWMPWLTTTVGGGGWVNAIGGTHGSLELPHGFGPGQLIVLLSSTLLVVGAMAGRGLSVKLSSIAALVVSLLIVALTVWYYKLNVNPPVSAEYGLYFGAAGGVCAVGCSLWAAVSAASPGRRRHREVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2X4</accession>
    <name>A0A7U8Y2X4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2X4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="103" mass="11062" checksum="5F3CAF38C1C1F173" modified="2021-06-02" version="1">MRPIHIAQLDKARPVLILTREVVRPHLTNVTVAPITTTVRGLATEVPVDAVNGLNQPSVVSCDNIQTIPVCDLGRQIGYLLASQEPALAEAIGNAFDLDWVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y325</accession>
    <name>A0A7U8Y325_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406627.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018723">
        <property type="entry name" value="DUF2254_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10011">
        <property type="entry name" value="DUF2254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="521" mass="56028" checksum="0A4BC9FEC7E86AD5" modified="2021-06-02" version="1">MLQRSLGVNGRKLAMSARSAKRERKNASTAASKCYVVPPSARGWVHAYSVTATSMLNRRKAILDYLQGAVWVLPTFGVAIGLGSGAVLSMIPVKSGTLIDKLMFQGTPGDARGVLIVVSATMITTIGIVFSLTVLSLQIASSQFSVRLLRTFLRDVPNQVVLAIFACTFAYSTGGLHTVGEHRDGGAFIPKVAVTGSLALAFVSIAALIYFLHHLMHSIQIDTIMDKVRLRTLGLVDQLYPESDTADRQVETPPSPPADAVPLLAPHSGYLQTVDVDDIAELAAASRYTALLVTFVGDYVTAGGLLGWCWRRGTAPGAPGSDFPQRCLRHVHIGFERTLQQDIRFGLRQMVDIALRALSPALNDPYTAIQVVHHLSAVESVLASRALPDDVRRDRAGELLFWLPYPSFATYLHVGCAQIRRYGSREPLVLTALLQLLSAVAQNCVDPSRRVAVQTQIALVVRAAQREFADESDRAMVLGAAARATEVVERPGTLAPPPSTFGQVAAAQAAASTIRSADRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y343</accession>
    <name>A0A7U8Y343_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA dehydrogenase fadE14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="3">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="2">
        <location>
            <begin position="117"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="259" mass="27825" checksum="123668CD23313656" modified="2021-06-02" version="1">MTAGSDLDDFRGLLAKAFDERVVAWTAEAEAQERFPRQLIEHLGVCGVFDAKWATDARPDVGKLVELAFALGQLASAGIGVGVSLHDSAIAILRRFGKSDYLRDICDQAIRGAAVLCIGASEESGGSDLQIVETEIRSRDGGFEVRGVKKFVSLSPIADHIMVVARSVDHDPTSRHGNVAVVAVPAAQVSVQTPYRKVGAGPLDTPRSASTPGYRPMHWLRGPARGWQPSVGDWLMSGCRSPGRSQRRVNGRSESPWPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y370</accession>
    <name>A0A7U8Y370_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03621</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407384.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y370"/>
    <dbReference type="GeneID" id="45425411"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041280">
        <property type="entry name" value="Big_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17964">
        <property type="entry name" value="Big_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031362359" evidence="4">
        <location>
            <begin position="23"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Big_10" evidence="6">
        <location>
            <begin position="37"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="167"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD13037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="271" mass="28701" checksum="719301725EAC509A" modified="2021-06-02" version="1">MRAVFGCAIAVVGIAGSVVAGPADIHLVAAKQSYGFAVASVLPTRGQVVGVAHPVVVTFSAPITNPANRHAAERAVEVKSTPAMTGKFEWLDNDVVQWVPDRFWPAHSTVELSVGSLSSDFKTGPAVVGVASISQHTFTVSIDGVEEGPPPPLPAPHHRVHFGEDGVMPASMGRPEYPTPVGSYTVLSKERSVIMDSSSVGIPVDDPDGYRLSVDYAVRITSRGLYVHSAPWALPALGLENVSHGCISLSREDAEWYYNAVDIGDPVIVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y377</accession>
    <name>A0A7U8Y377_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Adenylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="278"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="3">
        <location>
            <begin position="362"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="535" mass="58112" checksum="2AF93F93A37056A3" modified="2021-06-02" version="1">MPAKKTMAQRLGQALETMTRQCGQLPETPAYGSWLLGRVSESPSRRWVRIKRIVTVYIMTANLTGIVVALLVVTFAFPVPSIYTDAPWWVTFGVAPAYATLALAIGTYWITTRIVRASIRWAIEERAPSQADGRNTLLLPFRVAAVHLILWDIGGALLATLYGLANRVFVTIILFSVTICGVLVATNCYLFTEFALRPVAAKALEAGRPPRRFAPGIMGRTMTVWSLGSGVPVTGIATTALYVLLVHNLTETQLASAVLILSITTLIFGFLVMWILAWLTAAPVRVVRAALKRVEQGDLRGDLVVFDGTELGELQRGFNAMVNGLRERERVRDLFGRHVGREVAAAAERERPQLGGEDRHAAVVFVDIVGSTQLVDNQPAAHVVKLLNRFFAIVVNEVDRHHGLINKFAGDAALAIFGAPNRLDRPEDAALAAARAIAERLANEMPEVQAGIGVAAGQIVAGNVGAKQRFEYTVVGKPVNQAARLCELAKSHPARLLASSDTLHAASETERAHWSLGETVTLRGHEQPTRLAVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y3A0</accession>
    <name>A0A7U8Y3A0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="7" type="ORF">TBLG_03578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898859.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y3A0"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="191"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="196"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="418" mass="43577" checksum="48BD95E536595506" modified="2021-06-02" version="1">MVDHKRIPKQVIVGVSGGIAAYKACTVVRQLTEASHRVRVIPTESALRFVGAATFEALSGEPVCTDVFADVPAVPHVHLGQQADLVVVAPATADLLARAAAGRADDLLTATLLTARCPVLFAPAMHTEMWLHPATVDNVATLRRRGAVVLEPATGRLTGADSGAGRLPEAEEITTLAQLLLERHDALPYDLAGRKLLVTAGGTREPIDPVRFIGNRSSGKQGYAVARVAAQRGADVTLIAGHTAGLVDPAGVEVVHVSSAQQLADAVSKHAPTADVLVMAAAVADFRPAQVATAKIKKGVEGPPTIELLRNDDVLAGVVRARAHGQLPNMRAIVGFAAETGDANGDVLFHARAKLRRKGCDLLVVNAVGEGRAFEVDSNDGWLLASDGTESALQHGSKTLMASRIVDAIVTFLAGCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y428</accession>
    <name>A0A7U8Y428_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02737</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y428"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03769">
        <property type="entry name" value="SR_IS607_transposase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041718">
        <property type="entry name" value="IS607_transposase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="5">
        <location>
            <begin position="59"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="202" mass="22211" checksum="EF010572CB8355D5" modified="2021-06-02" version="1">MACCRNRGMNLAAWAERNGVARVTAYRWFHAGLLPVPARKVGRLILVDELASEAGAQPKTAVYARVSSADQKSDLDRQVARVTSWATAEQIPVDKVVTEVGSVLNGHRRKFPAVLRDLSVTRIVVEHRDRFCRFGSEYVHAALAAQGRELVVVDSAEVDDDLVWDMTEILTSMCARLYGKRAAQNRAKRAVAAAAVDDHEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y447</accession>
    <name>A0A7U8Y447_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable endonuclease 4</fullName>
            <ecNumber evidence="7">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nfo</name>
        <name evidence="9" type="ORF">TBLG_02812</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y447"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="8">
        <location>
            <begin position="14"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="252" mass="26845" checksum="170F550442C45A15" modified="2021-06-02" version="1">MLIGSHVSPTDPLAAAEAEGADVVQIFLGNPQSWKAPKPRDDAAALKAATLPIYVHAPYLINLASANNRVRIPSRKILQETCAAAADIGAAAVIVHGGHVADDNDIDKGFQRWRKALDRLETEVPVYLENTAGGDHAMARRFDTIARLWDVIGDTGIGFCLDTCHTWAAGEALTDAVDRIKAITGRIDLVHCNDSRDEAGSGRDRHANLGSGQIDPDLLVAAVKAAGAPVICETADQGRKDDIAFLRERTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y483</accession>
    <name>A0A7U8Y483_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase cmd</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02917</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403928.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y483"/>
    <dbReference type="GeneID" id="45424736"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="27"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="144" mass="16073" checksum="B546A6A564AF1DF2" modified="2021-06-02" version="1">MMDELRRTGLDKMNEVYAWDMPDMPGEFFALTVDHLFGRIWTRPGLSMRDRRMAVIAVLTAQGQSDLLEVQVNAVLHNDELTIDELRELAVFITHYVGFPLGSRLNSAIERVAAKRKQAAENGSLPDTKANVAEVLAKESGKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4D0</accession>
    <name>A0A7U8Y4D0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02799</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403381.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4D0"/>
    <dbReference type="GeneID" id="45424620"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="2"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="81" mass="9169" checksum="29985341768D033D" modified="2021-06-02" version="1">MLSFRADDHDVDLADAWARRLHIGRSELLRDALRRHLAALAADQDVQAYTERPLTDDENALAEIADWGPAEDWADWADAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4J4</accession>
    <name>A0A7U8Y4J4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Beta-thionase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Serine sulfhydrase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-homocysteine + L-serine = H2O + L,L-cystathionine</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405730.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4J4"/>
    <dbReference type="GeneID" id="45425049"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="340"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="464" mass="48635" checksum="BF53318ECB10BB81" modified="2021-06-02" version="1">MRIAQHISELIGGTPLVRLNSVVPDGAGTVAAKVEYLNPGGSSKDRIAVKMIEAAEASGQLKPGGTIVEPTSGNTGVGLALVAQRRGYKCVFVCPDKVSEDKRNVLIAYGAEVVVCPTAVPPHDPASYYSVSDRLVRDIDGAWKPDQYANPEGPASHYVTTGPEIWADTEGKVTHFVAGIGTGGTITGAGRYLKEVSGGRVRIVGADPEGSVYSGGAGRPYLVEGVGEDFWPAAYDPSVPDEIIAVSDSDSFDMTRRLAREEAMLVGGSCGMAVVAALKVAEEAGPDALIVVLLPDGGRGYMSKIFNDAWMSSYGFLRSRLDGSTEQSTVGDVLRRKSGALPALVHTHPSETVRDAIGILREYGVSQMPVVGAEPPVMAGEVAGSVSERELLSAVFEGRAKLADAVSAHMSPPLRMIGAGELVSAAGKALRDWDALMVVEEGKPVGVITRYDLLGFLSEGAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4L2</accession>
    <name>A0A7U8Y4L2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADPH:adrenodoxin oxidoreductase fprB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404631.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4L2"/>
    <dbReference type="GeneID" id="45424850"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="575" mass="61337" checksum="170C58599872A810" modified="2021-06-02" version="1">MPHVITQSCCNDASCVFACPVNCIHPTPDEPGFATSEMLYIDPVACVDCGACVTACPVSAIAPNTRLDFEQLPFVEINASYYPKRPAGVKLAPTSKLAPVTPAAEVRVRRQPLTVAVVGSGPAAMYAADELLVQQGVQVNVFEKLPTPYGLVRSGVAPDHQNTKRVTRLFDRIAGHRRFRFYLNVEIGKHLGHAELLAHHHAVLYAVGAPDDRRLTIDGMGLPGTGTATELVAWLNGHPDFNDLPVDLSHERVVIIGNGNVALDVARVLAADPHELAATDIADHALSALRNSAVREVVVAARRGPAHSAFTLPELIGLTAGADVVLDPGDHQRVLDDLAIVADPLTRNKLEILSTLGDGSAPARRVGRPRIRLAYRLTPRRVLGQRRAGGVQFSVTGTDELRQLDAGLVLTSIGYRGKPIPDLPFDEQAALVPNDGGRVIDPGTGEPVPGAYVAGWIKRGPTGFIGTNKSCSMQTVQALVADFNDGRLTDPVATPTALDQLVQARQPQAIGCAGWRAIDAAEIARGSADGRVRNKFTDVAEMLAAATSAPKEPLRRRVLARLRDLGQPIVLTVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y517</accession>
    <name>A0A7U8Y517_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407152.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425342"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="220" mass="23503" checksum="BEDB2AF51B806A1C" modified="2021-06-02" version="1">MTDDVRDVNTETTDATEVAEIDSAAGEAGDSATEAFDTDSATESTAQKGQRHRDLWRMQVTLKPVPVILILLMLISGGATGWLYLEQYRPDQQTDSGAARAAVAAASDGTIALLSYSPDTLDQDFATARSHLAGDFLSYYDQFTQQIVAPAAKQKSLKTTAKVVRAAVSELHPDSAVVLVFVDQSTTSKDSPNPSMAASSVMVTLAKVDGNWLITKFTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7E6</accession>
    <name>A0A7U8Y7E6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416354.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7E6"/>
    <dbReference type="GeneID" id="45427112"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="344" mass="38521" checksum="9DACAA3495F03770" modified="2021-06-02" version="1">MLKNAVLLACRAPSVHNSQPWRWVAESGSEHTTVHLFVNRHRTVPATDHSGRQAIISCGAVLDHLRIAMTAAHWQANITRFPQPNQPDQLATVEFSPIDHVTAGQRNRAQAILQRRTDRLPFDSPMYWHLFEPALRDAVDKDVAMLDVVSDDQRTRLVVASQLSEVLRRDDPYYHAELEWWTSPFVLAHGVPPDTLASDAERLRVDLGRDFPVRSYQNRRAELADDRSKVLVLSTPSDTRADALRCGEVLSTILLECTMAGMATCTLTHLIESSDSRDIVRGLTRQRGEPQALIRVGIAPPLAAVPAPTPRRPLDSVLQIRQTPEKGRNASDRNARETGWFSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Y0</accession>
    <name>A0A7U8Y7Y0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025246">
        <property type="entry name" value="IS30-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13936">
        <property type="entry name" value="HTH_38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="175"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="344" mass="40294" checksum="90A2087D0D9E3876" modified="2021-06-02" version="1">MRQISSRYLSEEERINIADLRRSGLSIRKIADQLGRAPSTVSRELRRNSRRDGQYRPFEAHRWAVQRRVRRHRRRIDKNPDLCELIAELLAQRWSPQQIARHLRRKYPDDRSMWLCHESIYQAVYQPQSRLIRPPQVKSPHRGPLRTGRTHRRAHLRPGRRRPRFAQPMLSIHQRPFDPADRSEPGHWEGDLIVGKNQGSAIGTLVERQTRLIRLLHLPTHDAYCLRIAITETMSDLSVTLVRSITWDQGIEMARHIDITADLGAPVYFCDSRSPWQRASNENSNGLLRQYFPKGTSLSTYTPDHLRAVEYEINNRPRQVLGHRSPAELFTALLTSPDHQLLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Z2</accession>
    <name>A0A7U8Y7Z2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smpB</name>
        <name evidence="4" type="ORF">TBLG_03721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="3">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416113.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7Z2"/>
    <dbReference type="GeneID" id="45427099"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="160" mass="18230" checksum="949F6327A03ACCD3" modified="2021-06-02" version="1">MSKSSRGGRQIVASNRKARHNYSIIEVFEAGVALQGTEVKSLREGQASLADSFATIDDGEVWLRNAHIPEYRHGSWTNHEPRRNRKLLLHRRQIDTLVGKIREGNFALVPLSLYFAEGKVKVELALARGKQARDKRQDMARRDAQREVLRELGRRAKGMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y817</accession>
    <name>A0A7U8Y817_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4143 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4143" evidence="1">
        <location>
            <begin position="58"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="269" mass="29586" checksum="EAA66720068C498C" modified="2021-06-02" version="1">MGLPRRPCCDTTGSARYRESVRRYPRIGEDSAAYRRRLCRESAKARNVDRVVKRDAADVSNLQRIADLPRLIRLLATRSASELNLSSLATDAEIPVRTLPPYLDLLETLYLIDRIPAWSTNLSKRVVDRPKVLLLDSGLAARLVNVSPTGAGPHANPNAAGAIIETFVIAELRRQLGWSQQAPRLFHYRDRDGAEVDLILETADGLIAAIEIKSAATLRGRDTRSISRLRDKVGARFAGGVILHTGPQAQPFGDRLAAVPIDILWSPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y818</accession>
    <name>A0A7U8Y818_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, tetR/acrR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03796</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416617.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y818"/>
    <dbReference type="GeneID" id="45427161"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="16"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="200" mass="21567" checksum="3642FF9D29D70186" modified="2021-06-02" version="1">MPPVTRTTEPPRRGGRGARQRILKAAAELFYCEGINATGVELIANKASVSKRTLYQHFPSKSALVEEYLRGLRQAAGEADKMPKASNATPRERLLALFDRPNRGDGRMRGCPFHNAAVEAAGEMPGVERIVHSHKRDYIKGLARLAREAGAAHPRSLGNQLAVLFEGAAALSTSLDDAGPWAHARAAAEVLIDQATARPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y851</accession>
    <name>A0A7U8Y851_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417772.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y851"/>
    <dbReference type="GeneID" id="45427362"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007995">
        <property type="entry name" value="DUF742"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36221">
        <property type="entry name" value="PTHR36221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05331">
        <property type="entry name" value="DUF742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="122" mass="13209" checksum="9F189410DD75094F" modified="2021-06-02" version="1">MFNPAGDRPKAGLVRPYTLTAGRTGTDVDLPLQAPVQTLPAGPAGRWPAYDMRRRILQLCIGSPSVAEISARLDLPVGVARVLVGDLVTSGYLRVHATLTDRSTRDERHELIGRTLRGLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y867</accession>
    <name>A0A7U8Y867_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="7"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="180" mass="20280" checksum="56193E15C34CA8F6" modified="2021-06-02" version="1">MPFTLTPAHQISYQMYAGPGADSMRAASQQLRELAFSADTTADSLNDTLFDLDDTWIGGSSAFMTDAALRYLKWLSKHSKRLWQTANTIHHLANTYEDIRQRVVPPAAIEDNREEVRRLIASDITGENAPAIAELDEQYQSYGDTNVQAMNLYAERAQTLLSQLPRWQEPPQIHQRGRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9W6</accession>
    <name>A0A7U8Y9W6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome P450 136 cyp136</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="492" mass="56170" checksum="2BCA3B5E95622F3E" modified="2021-06-02" version="1">MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKKLAEPPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLPGVAALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHRRIMQEAFVRSRLAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHELVTKVNKAFTITTRAGNAVIRTSVPPFTWWRGLRARELLENYFTARVKERREASGNDLLTVLCQTEDDDGNRFSDADIVNHMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESDRHGDGPLDIESLEQLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFGQLEIKTILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9X1</accession>
    <name>A0A7U8Y9X1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Electron transfer flavoprotein alpha subunit fixB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03647</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899889.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y9X1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="8">
        <location>
            <begin position="4"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD14749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="318" mass="31691" checksum="3C155E4CF5B0FE2D" modified="2021-06-02" version="1">MAEVLVLVEHAEGALKKVSAELITAARALGEPAAVVVGVPGTAAPLVDGLKAAGAAKIYVAESDLVDKYLITPAVDVLAGLAESSAPAGVLIAATADGKEIAGRLAARIGSGLLVDVVDVREGGVGVHSIFGGAFTVEAQANGDTPVITVRAGAVEAEPAAGAGEQVSVEVPAAAENAARITAREPAVAGDRPELTEATIVVAGGRGVGSAENFSVVEALADSLGAAVGASRAAVDSGYYPGQFQVGQTGKTVSPQLYIALGISGAIQHRAGMQTSKTIVAVNKDEEAPIFEIADYGVVGDLFKVAPQLTEAIKARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAC0</accession>
    <name>A0A7U8YAC0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="5"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="780" mass="76197" checksum="1B6D2CCEA7A6F6D5" modified="2021-06-02" version="1" fragment="single">MNFPVLPPEINSVLMYSGAGSSPLLAAAAAWDGLAEELGSAAVSFGQVTSGLTAGVWQGAAAAAMAAAAAPYAGWLGSVAAQAVAVAGQARAAVAAFEAALAATVDPAAVAVNRMAMRALAMSNLLGQNAAAIAAVEAEYELMWAADVAAMAGYHSGASAAAAALPAFSPPAQALGGGVGAFLNALFAGPAKMLRLNAGLGNVGNYNVGLGNVGIFNLGAANVGAQNLGAANAGSGNFGFGNIGNANFGFGNSGLGLPPGMGNIGLGNAGSSNYGLANLGVGNIGFANTGSNNIGIGLTGDNLTGIGGLNSGTGNLGLFNSGTGNIGFFNSGTGNFGVFNSGSYNTGVGNAGTASTGLFNVGGFNTGVANVGSYNTGSFNAGNTNTGGFNPGNVNTGWLNTGNTNTGIANSGNVNTGAFISGNFSNGVLWRGDYEGLWGLSGGSTIPAIPIGLELNGGVGPITVLPIQILPTIPLNIHQTFSLGPLVVPDIVIPAFGGGTAIPISVGPITISPITLFPAQNFNTTFPVGPFFGLGVVNISGIEIKDLAGNVTLQLGNLNIDTRINQSFPVTVNWSTPAVTIFPNGISIPNNPLALLASASIGTLGFTIPGFTIPAAPLPLTIDIDGQIDGFSTPPITIDRIPLNLGASVTVGPILINGVNIPATPGFGNTTTAPSSGFFNSGDGGVSGFGNFGAGSSGWWNQAQTEVAGAGSGFANFGSLGSGVLNFGSGVSGLYNTGGLPPGTPAVVSGIGNVGEQLSGLSSAGTALNQSLIINLGLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAD1</accession>
    <name>A0A7U8YAD1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved alanine and proline rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAD1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="467" mass="47660" checksum="D3C8E9DD2EA1DBCA" modified="2021-06-02" version="1">MADRLNVAERLAEGRPAAEHTQSYVRACHLVGYQHPDLTAYPAQIHDWYGSEDGLDLHALDADCAQLRAAASVLMEALRMERSQVAVLAAAWTGSGADAAVHFVQRHCETGNSVVTEVRAAAQRCESLRDNLWQLVDSKVATAIAIDERALAQRPAWLAAAEALTTEGADRPTAVEVVRQQIQPYVDDDVRNDWLTTMRSTTAGVAASYDAVTDQLASAPRAHFEIPDDLGPGRQPSPASVPAQPSATAAITPAAALPPPDPVPAVTSRPVTPSDFGSAPGDGSATPAGVGSAGGFGDAGGTGGLGGFAGLAGLANRIVDAVDSLLGSVAEQLGDPLAADNPPGAVDPFAEDAADNADDGDDAHPEEADEAAEPKEATEPDEADEVDDADESVPAERAQDVAEEATLPPVAEPPPPAAPPVAEPPPPVAAPAPPGAPEPANGPSPEALSEGATPCEIAADELPQAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF38</accession>
    <name>A0A7U8TF38_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme peroxidase bpoC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="15"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="262" mass="28381" checksum="26C4F81152054167" modified="2021-06-02" version="1">MINLAYDDNGTGDPVVFIAGRGGAGRTWHPHQVPAFLAAGYRCITFDNRGIGATENAEGFTTQTMVADTAALIETLDIAPARVVGVSMGAFIAQELMVVAPELVSSAVLMATRGRLDRARQFFNKAEAELYDSGVQLPPTYDARARLLENFSRKTLNDDVAVGDWIAMFSMWPIKSTPGLRCQLDCAPQTNRLPAYRNIAAPVLVIGFADDVVTPPYLGREVADALPNGRYLKIPDAGHLGFFERPEAVNTAMLKFFASVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF72</accession>
    <name>A0A7U8TF72_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family lipoprotein mce2E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02725</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF72"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="68"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="145"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="402" mass="43174" checksum="D2A202F324BAD82F" modified="2021-06-02" version="1">MRCGVSAGSANGKPNRWTLRCGVSAGHRGSVFLLAVLLAPVVLTSCTWRGIANVPLPVGRGMGPDRMTIYVQMPDTLALNTNSRVRVADVWVGTVRDISLRNWIATLTLELEPTVRLPANATAKIGQTSLLGTQHVELAAPPIPSPQPLKSGDTIGLKNSSAYPTVERTLASVALILTGGGIVNLDVIQTEILNILDGHAGQIREFLERLATFTAELNNQRGDLTRAIDSTNQLLTIIANRNDTLDRVLTDVPPLIEHFADTGQLFADATESLGRFSEVANRALAATRPNLHQTLQSLQRPLRQLERASPYVVGALKLGLTAPFNIDEVPNVIRGDYVNVSATFDVTLSALDNALLSGTGISGMLRALEQAWGRDPDTMIPDVRYTPNPNDAPGGPLVERAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFB1</accession>
    <name>A0A7U8TFB1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFB1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019239">
        <property type="entry name" value="VapB_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09957">
        <property type="entry name" value="VapB_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="83" mass="9426" checksum="1E9A71E3A687EA55" modified="2021-06-02" version="1">MGSDCGCGGYLWSMLKRVEIEVDDDLIQKVIRRYRVKGAREAVNLALRTLLGEADTAEHGHDDEYDEFSDPNAWVPRRSRDTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFD5</accession>
    <name>A0A7U8TFD5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403486.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFD5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023850">
        <property type="entry name" value="MftB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03967">
        <property type="entry name" value="mycofact_MftB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="109" mass="12076" checksum="F9D1767B50641A0D" modified="2021-06-02" version="1">MWGLLTVPAPAQARRADSSEFDPDRGWRLHPQVAVRPEPFGALLYHFGTRKLSFLKNRTILAVVQTLADYPDIRSACRGAGVDDCDQDPYLHALSVLAGSNMLVPRQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFE1</accession>
    <name>A0A7U8TFE1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403448.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424642"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021417">
        <property type="entry name" value="DUF3060"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11259">
        <property type="entry name" value="DUF3060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031566360" evidence="1">
        <location>
            <begin position="31"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="124" mass="13199" checksum="5DE50CD16DA891A3" modified="2021-06-02" version="1">MKWNTVAASLAAGVITIAVALAAPPPAAHAKNGDTHVTGQGIERTLDCNESTLLVNGTQNIVTALGTCWAVTVMGSSNTVVADTIINDITVYGWDETVFFRNGDPFIWDRGRELGMVNRLQRVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFH2</accession>
    <name>A0A7U8TFH2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403828.1">
        <property type="nucleotide sequence ID" value="NZ_KK338667.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="48" mass="4818" checksum="2AD26E6F349534CE" modified="2021-06-02" version="1">MLGLAMEAVASTGAAAPLGSHAAQIYAKFAADHADLDFSAVIETLRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFP3</accession>
    <name>A0A7U8TFP3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404314.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFP3"/>
    <dbReference type="GeneID" id="45424784"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="18"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="5">
        <location>
            <begin position="122"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="213" mass="23514" checksum="D2EDD9A9968AEA19" modified="2021-06-02" version="1">MRTAYHEQLSELSERLGEMCGLAGIAMERATQALLQADLVLAEQVISDHEKIATLSARAEESAFVLLALQAPVAGDLRAIVSAIQMVADIDRMGALALHVAKIARRRHPQHALPEEVNGYFAEMGRVAVELGNSAQEVVLSHDPEKAAQIREEDDAMDDLHRHLFTVLMDREWKHGVAAAVDVTLLSRFYERFADHAVEVARRVIFQATGAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFR0</accession>
    <name>A0A7U8TFR0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty-acid-CoA ligase fadD16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="278" mass="30108" checksum="C660DE8943C28060" modified="2021-06-02" version="1">MFTIGYSCASRGADSWLIRRCSVVQGCLDDPGATVEAIDDDGWPHTGDPCSPNSAASGKYGERPASVSTGDIHSLVIASDYRVPDPGRVWPLLQRNKSALADIGAHHVLIYASTHDSGRVLVMIGVRSREPIVELLRSRVFFDWFDAMGVDDIPAVFAGEIVDRFVAAPTTTQSTPRVPGVVVAAFASVNNVSNLTAEVRSAIARFTAAGIRKTWVFQAFDDAHEVLILQEFADEAGARQWIEHPDAAAEWMSGAGVGAYPPLFVGRFFDMMRIEALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFS6</accession>
    <name>A0A7U8TFS6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404596.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021391">
        <property type="entry name" value="DUF3027"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11228">
        <property type="entry name" value="DUF3027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="262" mass="27469" checksum="8466B819D3657DC3" modified="2021-06-02" version="1">MTGPTEESAVATVADWPEGLAAVLRGAADQARAAVVEFSGPEAVGDYLGVSYEDGNAATHRFIAHLPGYQGWQWAVVVASYSGADHATISEVVLVPGPTALLAPDWVPWEQRVRPGDLSPGDLLAPAKDDPRLVPGYTASGDAQVDETAAEIGLGRRWVMSAWGRAQSAQRWHDGDYGPGSAMARSTKRVCRDCGFFLPLAGSLGAMFGVCGNELSADGHVVDRQYGCGAHSDTTAPAGGSTPIYEPYDDGVLDIIEKPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFS9</accession>
    <name>A0A7U8TFS9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404633.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFS9"/>
    <dbReference type="GeneID" id="45424851"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041581">
        <property type="entry name" value="Glyoxalase_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18029">
        <property type="entry name" value="Glyoxalase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="152" mass="16098" checksum="CA23F189E3C94019" modified="2021-06-02" version="1">MAINVEPALSPHLVVDDAASAIDFYVKAFDAVELGRVPGPDGKLIHAALRINGFTVMLNDDVPQMCGGKSMTPTSLGGTPVTIHLTVTDVDAKFQRALNAGATVVTALEDQLWGDRYGVVADPFGHHWSLGQPVREVNMDEIQAAMSSQGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFT2</accession>
    <name>A0A7U8TFT2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404603.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424843"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019681">
        <property type="entry name" value="DUF2530"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10745">
        <property type="entry name" value="DUF2530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="91" mass="9512" checksum="FDD6D8E9D162E033" modified="2021-06-02" version="1">MSVENSQIREPPPLPPVLLEVWPVIAVGALAWLVAAVAAFVVPGLASWRPVTVAGLATGLLGTTIFVWQLAAARRGARGAQAGLETYLDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFT9</accession>
    <name>A0A7U8TFT9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404688.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFT9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="175" mass="18909" checksum="AD7024B10E5E1704" modified="2021-06-02" version="1">MEHVHWWLAGLAFTLGMVLTSTLMVRPVEHQVLVKKSVRGSSAKSKPPTARKPAVKSGTKREESPTAKTKVATESAAEQIPVAGEPAAEPIPVAGEPAARIPVVPYAPYGPGSARAGADGSGPQGWLVKGRSDTRLYYTPEDPTYDPTVAQVWFQDEESAARAFFTPWRKSTRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFY3</accession>
    <name>A0A7U8TFY3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03094</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404794.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFY3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="83"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="301" mass="32236" checksum="1B602BBD39733C40" modified="2021-06-02" version="1">MGESAESGSRQLPAMSPPRRSVAYRRKIVDALWWAACVCCLAVVITPTLWMLIGVVSRAVPVFHWSVLVQDSQGNGGGLRNAIIGTAVLAIGVILVGGTVSVLTGIYLSEFATGKTRSILRGAYEVLSGIPSIVLGYVGYLALVVYFDWGFSLAAGVLVLSVMSIPYIAKATESALAQVPTSYREAAEALGLPAGWALRKIVLKTAMPGIVTGMLVALALAIGETAPLLYTAGWSNSPPTGQLTDSPVGYLTYPIWTFYNQPSKSAQDLSYDAALLLIVFLLLLIFIGRLINWLSRRRWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFY5</accession>
    <name>A0A7U8TFY5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404748.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFY5"/>
    <dbReference type="GeneID" id="45424880"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="99" mass="9917" checksum="44F59AB38822222D" modified="2021-06-02" version="1">MSFVTIQPVVLAAATGDLPTIGTAVSARNTAVCAPTTGVLPPAANDVSVLTAARFTAHTKHYRVVSKPAALVHGMFVALPAATADAYATTEAVNVVATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFZ1</accession>
    <name>A0A7U8TFZ1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031121543" description="Phosphate-binding protein PstS" evidence="5">
        <location>
            <begin position="21"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="47"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="374" mass="38255" checksum="6324788F61FF38AA" modified="2021-06-02" version="1">MKIRLHTLLAVLTAAPLLLAAAGCGSKPPSGSPETGAGAGTVATTPASSPVTLAETGSTLLYPLFNLWGPAFHERYPNVTITAQGTGSGAGIAQAAAGTVNIGASDAYLSEGDMAAHKGLMNIALAISAQQVNYNLPGVSEHLKLNGKVLAAMYQGTIKTWDDPQIAALNPGVNLPGTAVVPLHRSDGSGDTFLFTQYLSKQDPEGWGKSPGFGTTVDFPAVPGALGENGNGGMVTGCAETPGCVAYIGISFLDQASQRGLGEAQLGNSSGNFLLPDAQSIQAAAAGFASKTPANQAISMIDGPAPDGYPIINYEYAIVNNRQKDAATAQTLQAFLHWAIIDGNKASFLDQVHFQPLPPAVVKLSDALIATISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFZ4</accession>
    <name>A0A7U8TFZ4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">purN</name>
        <name evidence="4" type="ORF">TBLG_03115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898661.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFZ4"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="14"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="99"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="215" mass="22416" checksum="55556C033097EAA1" modified="2021-06-02" version="1">MQEPLRVPPSAPARLVVLASGTGSLLRSLLDAAVGDYPARVVAVGVDRECRAAEIAAEASVPVFTVRLADHPSRDAWDVAITAATAAHEPDLVVSAGFMRILGPQFLSRFYGRTLNTHPALLPAFPGTHGVADALAYGVKVTGATVHLVDAGTDTGPILAQQPVPVLDGDDEETLHERIKVTERRLLVAAVAALATHGVTVVGRTATMGRKVTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFZ8</accession>
    <name>A0A7U8TFZ8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase_M23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="222"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="332" mass="35308" checksum="86F5236C5752E851" modified="2021-06-02" version="1">MAAIRTPRDRWPHHHRNEVTEIIPLDGFLDGLALYDELDFAELDDLDLGDDCVFDYEAQLLAAPELDDLDDADDLAPEWLVAPTVVLTPGVTPVSRRVGQHRKQPIGAARGRLLISAMAAGAAAAAAHTAIQQSETPRTETVLTAHASALNEGSGSNPPRGVQVIAAQPAASAAVHNAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLHAGIDLANAIGTPIYAVSDGVVIDAGPTAGYGMWVKLLHADGTVTLYGHVNTTLVSVGERVMAGDQIATMGSRGFSTGPHLHFEVLLGGTERVDPVPWLAKRGLSVGNYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG31</accession>
    <name>A0A7U8TG31_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="7">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rsmI</name>
        <name evidence="9" type="ORF">TBLG_03167</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405173.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG31"/>
    <dbReference type="GeneID" id="45424975"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018063">
        <property type="entry name" value="SAM_MeTrfase_RsmI_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01296">
        <property type="entry name" value="RSMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="285" mass="29665" checksum="2F799A8057F64634" modified="2021-06-02" version="1">MSSGRLLLGATPLGQPSDASPRLAAALATADVVAAEDTRRVRKLAKALDIRIGGRVVSLFDRVEALRVTALLDAINNGATVLVVSDAGTPVISDPGYRLVAACIDAGVSVTCLPGPSAVTTALVMSGLPAEKFCFEGFAPRKGAARRAWLAELAEERRTCVFFESPRRLAACLNDAVEQLGGARPAAICRELTKVHEEVVRGSLDELAIWAAGGVLGEITVVVAGAAPHAELSSLIAQVEEFVAAGIRVKDACSEVAAAHPGVRTRQLYDAVLQSRRETGGPAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG41</accession>
    <name>A0A7U8TG41_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein lpqT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG41"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019674">
        <property type="entry name" value="Lipoprotein_LpqN/LpqT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10738">
        <property type="entry name" value="Lpp-LpqN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031243423" evidence="1">
        <location>
            <begin position="30"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="226" mass="24081" checksum="38464105DA849980" modified="2021-06-02" version="1">MAGRRCPQDSVRPLAVAVAVATLAMSAVACGPKSPDFQSILSTSPTTSAVSTTTEVPVPLWKYLESVGVTGEPVAPSSLTDLTVSIPTPPGWAPMKNPNITPNTEMIAKGESYPTAMLMVFKLHRDFDIAEALKHGTADARLSTNFTELDSSTADFNGFPSSMIQGSYDLHGRRLHTWNRIVFPTGAPPAKQRYLVQLTITSLANEAVKHASDIEAIIAGFVVAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG51</accession>
    <name>A0A7U8TG51_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 2">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1 2">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name evidence="4" type="ORF">TBLG_03178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1 2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405251.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG51"/>
    <dbReference type="GeneID" id="45424985"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="191" mass="20456" checksum="1826278CBBA170BD" modified="2021-06-02" version="1">MAEPLLVVGLGNPGANYARTRHNLGFVVADLLAARLGAKFKAHKRSGAEVATGRSAGRSLVLAKPRCYMNESGRQIGPLAKFYSVAPANIIVIHDDLDLEFGRIRLKIGGGEGGHNGLRSVVAALGTKDFQRVRIGIGRPPGRKDPAAFVLENFTPAERAEVPTICEQAADATELLIEQGMEPAQNRVHAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG68</accession>
    <name>A0A7U8TG68_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405629.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG68"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="11"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="140"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="354" mass="36910" checksum="A5D345A63A218AF9" modified="2021-06-02" version="1">MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGEIIGSPPLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVVTPLGWFYPSEKEAAPLEVAAQAGNATLHGAGIGPGAVTELFPLLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGPMQKILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAPIDSPIGVIEPGQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAGERYEIEVRGSPDTCVTIKGWQPQTVAAGLKSNPGIVATAAHCVNAIPATCAAPAGIQSFFDLPLITGRAAPGLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG78</accession>
    <name>A0A7U8TG78_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405719.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG78"/>
    <dbReference type="GeneID" id="45425044"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010539">
        <property type="entry name" value="UCP009160"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41282">
        <property type="entry name" value="PTHR41282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12811">
        <property type="entry name" value="BaxI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009160">
        <property type="entry name" value="UCP009160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="278" mass="29144" checksum="6EE503639966DC3F" modified="2021-06-02" version="1">MRETSNPVFRSLPKQRGGYAQFGTGTAQQGFPADPYLAPYREAKATRPLTIDDVVTKTGLTLAMLAGTAVVSYFLVASNVALAMPLTLVGALGGLALVLVATFGRKQDNPAIVLSYAALEGLFLGAISFVLANFTVASANAGVLIGEAILGTMGVFFGMLVVYKTGAIRVTPKFTRMVVAALFGVLVLMLGNLVLAMFNVGGGEGLGLRSPGPLGIIFSLVCIGIAAFSFLIDFDAADQMIRAGAPEKAAWGVALGLTVTLVWLYIEILRLLSYLQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGB6</accession>
    <name>A0A7U8TGB6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898730.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGB6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="212" mass="22957" checksum="EE9B4278D0E502CA" modified="2021-06-02" version="1">MATAPYGVRLLVGAATVAVEETMKLPRTILMYPMTLASQAAHVVMRFQQGLAELVIKGDNTLETLFPPKDEKPEWATFDEDLPDALEGTSIPLLGLSDASEAKNDDRRSDGRFALYSVSDTPETTTASRSADRSTNPKTAKHPKSAAKPTVPTPAVAAELDYPALTLAQLRARLHTLDVPELEALLAYEQATKARAPFQTLLANRITRATAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGC4</accession>
    <name>A0A7U8TGC4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">IS4 family Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="3">
        <location>
            <begin position="15"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="183" mass="20169" checksum="DADC7E4C9B913617" modified="2021-06-02" version="1" fragment="single">ALSNYKKSADEPDDHAIGRSRGGLTTKIHALTDQREAPVRIRLTAGQAGDNPQLLPLLDDYRHASTEYALGSTDFRLLADKAYSHPSTRAALRSKKIKHTIPERQDQIDRRKAKGSAGGRPPAFDAALYGLRNTVERGFHRLKQWRGIATRYDKYALTYLGGVLLACAVIHARVGTPKLGDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGC8</accession>
    <name>A0A7U8TGC8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase echA11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405951.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGC8"/>
    <dbReference type="GeneID" id="45425114"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="268" mass="27616" checksum="0411C3944B5763F7" modified="2021-06-02" version="1">MPDSGIAALTPVTGLNVTLTDRVLSVRINRPSSLNSLTVPILTGIADTLERAAADPVVKVVRLGGVGRGFSSGVSMSVDDVWGGGPPTAIVEEANRAVRAVAALPHPVVAVVQGPAVGVAVSLALACDFILASDSAFFMLANTKVALMPDGGASALVAAATGRIRAMRLALLAEQLPAREALAWGLISAVYPDSDFEAEVDKVISRLLAGPALAFAQAKNAINAAALTELEPTFARELDGQEVLLRTHDFAEGAAAFLQRRTPNFTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGI6</accession>
    <name>A0A7U8TGI6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003908664.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427963"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="57" mass="6188" checksum="99F73CDED2F9A85E" modified="2021-06-02" version="1">MYSGAMKSISVGELRQNPAPMIADLERGEPYALTRHNHRIGTIIPAVSSATLIPRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGK8</accession>
    <name>A0A7U8TGK8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406347.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl_transf_3" evidence="2">
        <location>
            <begin position="23"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="383" mass="42314" checksum="23819C64BD051E7C" modified="2021-06-02" version="1">MTLPKERAAQGGLERIAHVDRVASLTGIRAVAALLVVGTHAAYTTGKYTHGYWGLMSSRMEIGVPIFFVLSGFLLFRPWVKSAATGGPPPSLSRYAWHRVRRIMPAYTVTVLLAYLVYHFRTAGPNPGHTWVGLFRNLTLTQIYTDGYLGAFLHQGLTQMWSLAVEVAFYLALPALAYLLLVLVCRRRWQPRLLLATMAGLTMISPAWLILVHNTHWMPDGARLWLPTYLAWFVGGMMLAVLAAMGVRCYAFVAIPLAVICYFIVSTPIAGAPTTSPTALAEALVKTAFYAVIAVLAVAPLALGDQGWYAQLLASRPMVFLGEISYEIFLIHLVTMEIAMVDVLGYRVYTSSMVNLCLVTLVLTIPLAWLLHRFTRVQGDRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGL8</accession>
    <name>A0A7U8TGL8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator embR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03448</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AfsR/DnrI/RedD regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15831">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01043">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SSF49879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="4">
        <location>
            <begin position="308"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="2"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="388" mass="41994" checksum="BBF3B9F400233731" modified="2021-06-02" version="1">MAGSATVEKRLDFGLLGPLQMTIDGTPVPSGTPKQRAVLAMLVINRNRPVGVDALITALWEEWPPSGARASIHSYVSNLRKLLGGAGIDPRVVLAAAPPGYRLSIPDNTYDLGRFVAEKTAGVHAAAAGRFEQASRHLSAALREWRGPVLDDLRDFQFVEPFATALVEDKVLAHTAKAEAEIACGRASAVIAELEALTFEHPYREPLWTQLITAYYLSDRQSDALGAYRRVKTTLADDLGIDPGPTLRALNERILRQQPLDAKKSAKTTAAGTVTVLDQRTMASGQQAVAYLHDIASGRGYPLQAAATRIGRLHDNDIVLDSANVSRHHAVIVDTGTNYVINDLRSSNGVHVQHERIRSAVTLNDGDHIRICDHEFTFQISAGTHGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGN3</accession>
    <name>A0A7U8TGN3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide-transport ATP-binding protein ABC transporter oppD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03462</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406602.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="350"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="612" mass="65293" checksum="9E03D437C6EF0992" modified="2021-06-02" version="1">MSPLLEVTDLAVTFRTDGDPVTAVRGISYRVEPGEVVAMVGESGSGKSAAAMAVVGLLPEYAQVRGSVRLQGTELLGLADNAMSRFRGKAIGTVFQDPMSALTPVYTVGDQIAEAIEVHQPRVGKKAARRRAVELLDLVGISQPQRRSRAFPHELSGGERQRVVIAIAIANDPDLLICDEPTTALDVTVQAQILDVLKAARDVTGAGVLIITHDLGVVAEFADRALVMYAGRVVESAGVNDLYRDRRMPYTVGLLGSVPRLDAAQGTRLVPIPGAPPSLAGLAPGCPFAPRCPLVIDECLTAEPELLDVATDHRAACIRTELVTGRSAADIYRVKTEARPAALGDASVVVRVRHLVKTYRLAKGVVLRRAIGEVRAVDGISLELRQGRTLGIVGESGSGKSTTLHEILELAAPQSGSIEVLGTDVATLGTAERRSLRRDIQVVFQDPVASLDPRLPVFDLIAEPLQANGFGKNETHARVAELLDIVGLRHGDASRYPAEFSGGQKQRIGIARALALQPKILALDEPVSALDVSIQAGIINLLLDLQEQFGLSYLFVSHDLSVVKHLAHQVAVMLAGTVVEQGDSEEVFGNPKHEYTRRLLGAVPQPDPARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGW8</accession>
    <name>A0A7U8TGW8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021941">
        <property type="entry name" value="DUF3556_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12077">
        <property type="entry name" value="DUF3556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD13035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="589" mass="65309" checksum="707840A4974BBFB8" modified="2021-06-02" version="1">MGFLKPDLPDVDHDTWLTQPRRTRLQVVTRDWVEHGFGTPYAVYLLYLTKIAVYVAAGAAIISLTPGLGGLSRIGDWWTQPIVYQKVIVFTLLFEVLGFGCGSGPLTGRFWPPIGGFLYWLRPNTIRLPAWPDKVPFTQGDTRTVVDVALYAIVLIGGVWALLSPGSPGPGGTPVTAAGDVGLINPVLVVPTIVALGVLGLRDKTIFLAARGEHYWLKLFVFFFPFTDQIAAFKIIMLCLWWGAATSKLNHHFPYVVAVMTSNNALLRSRVFNPIKHLLYRDHANDLRPSWLPKLMAHGGGTTAEFLVPGILVLVADGHPWRWFLIGFMVLFHLNILSNLPMGVPLEWNVFFIFSLCYLFGHYGAITATDLRSPLLLAIVIAVVAVVIMGNLLPEKISFLPAMRYYAGNWATSIWCFRGDAEATMETSVVKSSALVVNQLAKLYDGATAEIMTDKVAAFRAMHTHGRALNGLLPRALDDEAHYRIREGEIVAGPLVGWNFGEGHLHNEQLVAAVQRRCNFADGDLRVIILEGQPIHVQKQWYRIVDAKTGLFEAGYVTVEDMLSRQPWPEPGDEFPVHVTTQRGTPSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH07</accession>
    <name>A0A7U8TH07_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_02879</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403731.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH07"/>
    <dbReference type="GeneID" id="45424700"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000838">
        <property type="entry name" value="RNA_pol_sigma70_ECF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01063">
        <property type="entry name" value="SIGMA70_ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4" evidence="8">
        <location>
            <begin position="119"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="177" mass="19538" checksum="8E13D528AEDD9E16" modified="2021-06-02" version="1">MARVSGAAAAEAALMRALYDEHAAVLWRYALRLTGDAAQAEDVVQETLLRAWQHPEVIGDTARPARAWLFTVARNMIIDERRSARFRNVVGSTDQSGTPEQSTPDEVNAALDRLLIADALAQLSAEHRAVIQRSYYRGWSTAQIATDLGIAEGTVKSRLHYAVRALRLTLQELGVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH89</accession>
    <name>A0A7U8TH89_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403139.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424567"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="78" mass="8212" checksum="10D8C631953A6B73" modified="2021-06-02" version="1">MKAVVDAAGRIVVPKPLREALGLQPGSTVEISRYGAGLHLIPTGRTARLEEENGVLVATGETTIDDEVVFGLIDSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THF7</accession>
    <name>A0A7U8THF7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898579.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THF7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="248" mass="25966" checksum="2F62C15EEBF4A949" modified="2021-06-02" version="1">MFDSKVAIVTGAAQGIGQAYAQALAREGASVVVADINADGAAAVAKQIVADGGTAIHVPVDVSDEDSAKAMVDRAVGAFGGIDYLVNNAAIYGGMKLDLLLTVPLDYYKKFMSVNHDGVLVCTRAVYKHMAKRGGGAIVNQSSTAAWLYSNFYGLAKVGVNGLTQQLARELGGMKIRINAIAPGPIDTEATRTVTPAELVKNMVQTIPLSRMGTPEDLVGMCLFLLSDSASWITGQIFNVDGGQIIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THK7</accession>
    <name>A0A7U8THK7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-alanyl-D-alanine dipeptidase</fullName>
            <shortName evidence="3">D-Ala-D-Ala dipeptidase</shortName>
            <ecNumber evidence="3">3.4.13.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>D-alanyl-D-alanine + H2O = 2 D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20661"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="EC" id="3.4.13.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M15D family.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.22" evidence="3"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898609.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THK7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000755">
        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01427">
        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030958231" description="D-alanyl-D-alanine dipeptidase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="256" mass="27321" checksum="87F4A057413762B0" modified="2021-06-02" version="1">MRLIGRLRLLMVGLVVICGACACDRVSAGRWSESPSATSWPVRPVNTTTPSGPVPPVSEAARAAGLVDVRGVVPDAAIDLRYATANNFTGTQLYPPGARCLVHESMAEGLAAAAAVLRPHGQVLVFWDCYRPHDVQVRMFDVVPNPAWVARPGKYAHSHEAGRSVDVTFASAQRQCPSVRRSGELCLADMGTDFDDFSSRATAFATQGVSAEAQANRAHLRAAMQAGGLTVYSGEWWHFDGPGAGVDRPILEVPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THL1</accession>
    <name>A0A7U8THL1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rplY</name>
        <name evidence="6" type="synonym">ctc</name>
        <name evidence="9" type="ORF">TBLG_03179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405254.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THL1"/>
    <dbReference type="GeneID" id="45424986"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_TL5_C" evidence="8">
        <location>
            <begin position="103"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="215" mass="22441" checksum="51DD6ABE59CBF236" modified="2021-06-02" version="1">MAKSASNQLRVTVRTETGKGASRRARRAGKIPAVLYGHGAEPQHLELPGHDYAAVLRHSGTNAVLTLDIAGKEQLALTKALHIHPIRRTIQHADLLVVRRGEKVVVEVSVVVEGQAGPDTLVTQETNSIEIEAEALSIPEQLTVSIEGAEPGTQLTAGQIALPAGVSLISDPDLLVVNVVKAPTAEELEGEVAGAEEAEEAAVEAGEAEAAGESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THL8</accession>
    <name>A0A7U8THL8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein kdpF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405316.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THL8"/>
    <dbReference type="GeneID" id="45425002"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043462">
        <property type="term" value="P:regulation of ATP-dependent activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011726">
        <property type="entry name" value="KdpF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09604">
        <property type="entry name" value="Potass_KdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02115">
        <property type="entry name" value="potass_kdpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="30" mass="3256" checksum="7C5A5CDEFABC7305" modified="2021-06-02" version="1">MTTVDNIVGLVIAVALMAFLFAALLFPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THM1</accession>
    <name>A0A7U8THM1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404010.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THM1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="5"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="101" mass="11192" checksum="039D1B1EA1ACA6A0" modified="2021-06-02" version="1">MTSPVAVIARFMPRPDARSALRALLDAMITPTRAEDGCRSYDLYESADGGELVLFERYRSRIALDEHRGSPHYLNYRAQVGELLTRPVAVTVLAPLDEASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THM5</accession>
    <name>A0A7U8THM5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404135.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THM5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021426">
        <property type="entry name" value="DUF3073"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11273">
        <property type="entry name" value="DUF3073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="60" mass="6900" checksum="486630323FBCC826" modified="2021-06-02" version="1">MGRGRAKAKQTKVARELKYSSPQTDFQRLQRELSGTGTDRLDGDGPSDDDSWNDEDDWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THP7</accession>
    <name>A0A7U8THP7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03050</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THP7"/>
    <dbReference type="UniPathway" id="UPA00215"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="32"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="341"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="505" mass="53873" checksum="626018C99918256C" modified="2021-06-02" version="1">MRQQQEADVVALGRKPGLLCVPERFRAMDLPMAAADALFLWAETPTRPLHVGALAVLSQPDNGTGRYLRKVFSAAVARQQVAPWWRRRPHRSLTSLGQWSWRTETEVDLDYHVRLSALPPRAGTAELWALVSELHAGMLDRSRPLWQVDLIEGLPGGRCAVYVKVHHALADGVSVMRLLQRIVTADPHQRQMPTLWEVPAQASVAKHTAPRGSSRPLTLAKGVLGQARGVPGMVRVVADTTWRAAQCRSGPLTLAAPHTPLNEPIAGARSVAGCSFPIERLRQVAEHADATINDVVLAMCGGALRAYLISRGALPGAPLIAMVPVSLRDTAVIDVFGQGPGNKIGTLMCSLATHLASPVERLSAIRASMRDGKAAIAGRSRNQALAMSALGAAPLALAMALGRVPAPLRPPNVTISNVPGPQGALYWNGARLDALYLLSAPVDGAALNITCSGTNEQITFGLTGCRRAVPALSILTDQLAHELELLVGVSEAGPGTRLRRIAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THW9</accession>
    <name>A0A7U8THW9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404907.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="115" mass="12415" checksum="DB4928D8C4D74FD4" modified="2021-06-02" version="1">MRVPSQWMISSRVTVAWNIVGYLVYAALAFVGGFAVWFSLFFAMATDGCHDSACDASYHVFPAMVTMWIGVGAVLLLTLVVMVRNSSRGNVVIGWPFVGLLALGLVYVAADAVLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THX8</accession>
    <name>A0A7U8THX8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="10">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">glgC</name>
        <name evidence="13" type="ORF">TBLG_03389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Capsule biogenesis; capsule polysaccharide biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10 11">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="10"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406249.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THX8"/>
    <dbReference type="GeneID" id="45425183"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="UniPathway" id="UPA00934"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045227">
        <property type="term" value="P:capsule polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00808">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="12">
        <location>
            <begin position="9"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha-D-glucose 1-phosphate binding" evidence="10">
        <location>
            <begin position="179"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="10">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="site" description="Could play a key role in the communication between the regulatory and the substrate sites" evidence="10">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="404" mass="43800" checksum="D1D7C8934A8CC5D2" modified="2021-06-02" version="1">MREVPHVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLIDFVLSNLVNARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYTGSADAIYQSLNLIYDEDPDYIVVFGADHVYRMDPEQMVRFHIDSGAGATVAGIRVPRENATAFGCIDADDSGRIRSFVEKPLEPPGTPDDPDTTFVSMGNYIFTTKVLIDAIRADADDDHSDHDMGGDIVPRLVADGMAAVYDFSDNEVPGATDRDRAYWRDVGTLDAFYDAHMDLVSVHPVFNLYNKRWPIRGESENLAPAKFVNGGSAQESVVGAGSIISAASVRNSVLSSNVVVDDGAIVEGSVIMPGTRVGRGAVVRHAILDKNVVVGPGEMVGVDLEKDRERFAISAGGVVAVGKGVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THY5</accession>
    <name>A0A7U8THY5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Para-aminobenzoate synthase component I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="271"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="541" mass="56352" checksum="97ED1F9A53029BFE" modified="2021-06-02" version="1">MAGLPIAFSGPRWLALLLQPLSGPPSTSAKHTTTPSVLFLLLKTIATSRSHRASTSRGQRETALALAARTATPPGTETGAGHGSNLAWELSTRTKSPRSHLRCENPQFCQARTVRIDRLGDLGGAPAVLRAVGRATSRLDLPPPAALTGEWFGALAVIAPSVSIQPVSGDDVFSGPPGTGGPDATGAVGGGWVGYLSYPDAGADGRPHRIPEAAGGWTDCVLRRDRDGQWWYESLSGAPIADWLASALATTRASVARPAPACRIDWEPADRAAHRDGVLACLEAIGAGEVYQACVCTQFAGTVTGSPLDFFIDGFGRTAPSRSAFVAGPWGAVASLSPELFLRRRGSVVTSSPIKGTLPLDAPPSALRASAKEVAENIMIVDLVRNDLGRVAVTGTVTVPELLVVRPAPGVWHLVSTVSARVPLEEPMSALLDAAFPPASVTGTPKLRARQLISQWERYRRGIYCGTVGLASPVAGCELNVAIRTVEFDTAGNAVLGVGGGITADSDPDAEWAECLHKAAPIVGLPAATRTTPARLASKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI48</accession>
    <name>A0A7U8TI48_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406887.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI48"/>
    <dbReference type="GeneID" id="45425302"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="304" mass="32170" checksum="FC03A16FF88A7E03" modified="2021-06-02" version="1">MTRPRPPLGPAMAGAVDLSGIKQRAQQNAAASTDADRALSTPSGVTEITEANFEDEVIVRSDEVPVVVLLWSPRSEVCVDLLDTLSGLAAAAKGKWSLASVNVDVAPRVAQIFGVQAVPTVVALAAGQPISSFQGLQPADQLSRWVDSLLSATAGKLKGAASSEESTEVDPAVAQARQQLEDGDFVAARKSYQAILDANPGSVEAKAAIRQIEFLIRATAQRPDAVSVADSLSDDIDAAFAAADVQVLNQDVSAAFERLIALVRRTSGEERTRVRTRLIELFELFDPADPEVVAGRRNLANALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI78</accession>
    <name>A0A7U8TI78_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03301</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="319"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="419" mass="45492" checksum="6725D67DD3A1E13C" modified="2021-06-02" version="1">RIDHPGAPGAAGALRDRATPAASVEHTLINQIGEHPPRELAASCMTLRRAHHRSEAKRRVAEAADLGQRRALTGEPLPPLLTATAKAQRHGLIGDGHVEVIRAFVHRLPSWVDLKTLEKAERDLAKQATQYRPDQLAKLAARIMDCLNPDGDYTDEDRARRRGLTLGKQDVDGMSRLSGYVTPELRATIEAVWAKLAAPGMCNPEQKAPCVNGAPSKEQARRDTRSCPQRNHDALNAGLRSLLTSGNLGQHNGLPASIIVTTTLKDLEAAAGAGLTGGGTILPISDVIRLARHANHYLAIFDRGKALALYHTKRLASPAQRIMLYAKDSGCSAPGCDVPGYYCEVHHVTPYAQCRNTDVNDLTLGCGGHHPLAERGWTTRKNAHGDTEWLPPPHLDHGQPRVNTFHHPEKLLADDEGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI82</accession>
    <name>A0A7U8TI82_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamoyl-phosphate synthase small chain</fullName>
            <ecNumber evidence="2">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Carbamoyl-phosphate synthetase glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">carA</name>
        <name evidence="4" type="ORF">TBLG_03569</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="2"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407208.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI82"/>
    <dbReference type="GeneID" id="45425362"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="SSF52021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CPSase_sm_chain" evidence="3">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="CPSase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="376" mass="39767" checksum="DF057465F47AE46D" modified="2021-06-02" version="1">MSKAVLVLEDGRVFTGRPFGATGQALGEAVFSTGMSGYQETLTDPSYHRQIVVATAPQIGNTGWNGEDSESRGERIWVAGYAVRDPSPRASNWRATGTLEDELIRQRIVGIAGIDTRAVVRHLRSRGSMKAGVFSDGALAEPADLIARVRAQQSMLGADLAGEVSTAEPYVVEPDGPPGVSRFTVAALDLGIKTNTPRNFARRGIRCHVLPASTTFEQIAELNPHGVFLSNGPGDPATADHVVALTREVLGAGIPLFGICFGNQILGRALGLSTYKMVFGHRGINIPVVDHATGRVAVTAQNHGFALQGEAGQSFATPFGPAVVSHTCANDGVVEGVKLVDGRAFSVQYHPEAAAGPHDAEYLFDQFVELMAGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIE6</accession>
    <name>A0A7U8TIE6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the MIP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406273.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIE6"/>
    <dbReference type="GeneID" id="45425199"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="6">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="134"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="390" mass="41063" checksum="A7BD4DB9473AD11E" modified="2021-06-02" version="1">MPSRLHSAVMSGTRDGDLNAAIRTALGKVIDPELRRPITELGMVKSIDTGPDGSVHVEIYLTIAGCPKKSEITERVTRAVADVPGTSAVRVSLDVMSDEQRTELRKQLRGDTREPVIPFAQPDSLTRVYAVASGKGGVGKSTVTVNLAAAMAVRGLSIGVLDADIHGHSIPRMMGTTDRPTQVESMILPPIAHQVKVISIAQFTQGNTPVVWRGPMLHRALQQFLADVYWGDLDVLLLDLPPGTGDVAISVAQLIPNAELLVVTTPQLAAAEVAERAGSIALQTRQRIVGVVENMSGLTLPDGTTMQVFGEGGGRLVAERLSRAVGADVPLLGQIPLDPALVAAGDSGVPLVLSSPDSAIGKELHSIADGLSTRRRGLAGMSLGLDPTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIG6</accession>
    <name>A0A7U8TIG6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406626.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425261"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="210" mass="23550" checksum="F098568DEFE0EC6F" modified="2021-06-02" version="1">MCVSVGESVAQSLQQWDRKLWDVAMLHACNAVDETGRKRYPTLGVGTRFRTALRDSLDIYGVMATPGVDLEKTRFPVGVRSDLLPDKRPDIADVLYGIHRWLHGHADESSVEFEVSPYVNASAALRIANDGKIQLPKSAILGLLAVAVFAPENKGEVIPPDYQLSWYDHVFFISVWWGWQDHFREIVNVDRASLVALDFGDLWNGWTPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIJ6</accession>
    <name>A0A7U8TIJ6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase fadD33</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406950.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIJ6"/>
    <dbReference type="GeneID" id="45425323"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="28"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="521" mass="53957" checksum="2D432512077122DB" modified="2021-06-02" version="1">MSELAAVLTRSMQASAGDLMVLDRETSLWCRHPWPEVHGLAESVAAWLLDHDRPAAVGLVGEPTVELVAAIQGAWLAGAAVSILPGPVRGANDQRWADATLTRFLGIGVRTVLSQGSYLARLRSVDTAGVTIGDLSTAAHTNRSATPVASEGPAVLQGTAGSTGAPRTAILSPGAVLSNLRGLNQRVGTDAATDVGCSWLPLYHDMGLAFVLSAALAGAPLWLAPTTAFTASPFRWLSWLSDSGATMTAAPNFAYNLIGKYARRVSEVDLGALRVTLNGGEPVDCDGLTRFAEAMAPFGFDAGAVLPSYGLAESTCAVTVPVPGIGLLADRVIDGSGAHKHAVLGNPIPGMEVRISCGDQAAGNASREIGEIEIRGASMMAGYLGQQPIDPDDWFATGDLGYLGAGGLVVCGRAKEVISIAGRNIFPTEVELVAAQVRGVREGAVVALGTGDRSTRPGLVVAAEFRGPDEANARAELIQRVASECGIVPSDVVFVSPGSLPRTSSGKLRRLAVRRSLEMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIK0</accession>
    <name>A0A7U8TIK0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide chain release factor 1</fullName>
            <shortName evidence="5">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prfA</name>
        <name evidence="7" type="ORF">TBLG_03481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406670.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIK0"/>
    <dbReference type="GeneID" id="45425273"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0488">Methylation</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="6">
        <location>
            <begin position="229"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="5">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="357" mass="39036" checksum="F6DE97400EFC0663" modified="2021-06-02" version="1">MTQPVQTIDVLLAEHAELELALADPALHSNPAEARRVGRRFARLAPIVATHRKLTSARDDLETARELVASDESFAAEVAALEARVGELDAQLTDMLAPRDPHDADDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWAVTVLDETTSDLGGYKDATLAIASKADTPDGVWSRMKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEVGQVQIDESDLRIDVFRSSGKGGQGVNTTDSAVRITHLPTGIVVTCQNERSQLQNKTRALQVLAARLQAMAEEQALADASADRASQIRTVDRSERIRTYNFPENRITDHRIGYKSHNLDQVLDGDLDALFDALSAADKQSRLRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIP6</accession>
    <name>A0A7U8TIP6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin biosynthesis protein moeY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="90"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="715" mass="78179" checksum="D880AF921E7164C8" modified="2021-06-02" version="1">MTIPHEGGSTGILVLRDDDHDDVLVLDRLRSDPSIEFVDRFAEQLAGVRRLLPQPDPDLLEEAKRWAYYPWRRMVVAILGPRGFRAVRLDRNRHLITAEEQRALHALRVGVVGLSAGHAIAYTLAAEGACGTLRLADFDKIELSNLNRVPVGVFDIGLNKAMIAARRIAELDPYLAVDLVTSGLSPESVDEFLDGLDVVIEECDSLDIKVILRQAACARGVPVLMATSDRGLVDVERYDVEPGRPIFHGLLGDIDADKLCGLTTKDKVPHVLNILDCQELSARCAASMIEVDQTLWGWPQLAGDIWVGAATVAEAVRRIGLGEPLESGRVRVDVSAALDRLDQPPMPSRGNGWLLESVPPTAPAEPQPTSEIVAQAAIRAPSGGNVQPWHIVAKQHSLTIRLAPEHTSAMDIAFRGSAVAVGAAMFNARVAAAAHRVLGSVEFDESQPDSPLQATMHFGRGDDPSLAALYRPMLLRTTNRHHGMPGHVHPATVELLTNTAAAEGARLQLLLSRNEIDRAATILAAADRIRYLTPRLHEEMMSELRWPGDPSLDAGIDVRSLELDSGELRVLDILRRSDVVARLAQWDCGTALEDNTNERVSASSALAIVYVDGATLTDFARGGSAMQAVWIVAQQHGLAVQPMSPIFLYARGRHDLDQASPHFAAQLHRLQLDFRELVKPGKEGHEVLIFRLFHAPPPSVCSRRRVRHAIPEPHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIR5</accession>
    <name>A0A7U8TIR5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="7">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">OMP decarboxylase</fullName>
            <shortName evidence="7">OMPDCase</shortName>
            <shortName evidence="7">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pyrF</name>
        <name evidence="9" type="ORF">TBLG_03571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the OMP decarboxylase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407220.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIR5"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01215">
        <property type="entry name" value="OMPdecase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011995">
        <property type="entry name" value="OMPdecase_type-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43375">
        <property type="entry name" value="PTHR43375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02127">
        <property type="entry name" value="pyrF_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="274" mass="27377" checksum="369BAE076FB3D143" modified="2021-06-02" version="1">MTGFGLRLAEAKARRGPLCLGIDPHPELLRGWDLATTADGLAAFCDICVRAFADFAVVKPQVAFFESYGAAGFAVLERTIAELRAADVLVLADAKRGDIGATMSAYATAWVGDSPLAADAVTASPYLGFGSLRPLLEVAAAHGRGVFVLAATSNPEGAAVQNAAADGRSVAQLVVDQVGAANEAAGPGPGSIGVVVGATAPQAPDLSAFTGPVLVPGVGVQGGRPEALGGLGGAASSQLLPAVAREVLRAGPGVPELRAAGERMRDAVAYLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR87</accession>
    <name>A0A7U8TR87_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899924.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR87"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="51"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="200" mass="21828" checksum="1514A61D118F96CF" modified="2021-06-02" version="1">MSPSPSALLADHPDRIRWNAKYECADPTEAVFAPISWLGDVLQFGVPEGPVLELACGRSGTALGLAAAGRCVTAIDVSDTALVQLELEATRRELADRLTLVHADLCSWQSGDGRFALVLCRLFWHPPTFRQACEAVAPGGVVAWEAWRRPIDVARDTRRAEWCLKPGQPESELPAGFTVIRVVDTDGSEPSRRIIAQRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRF4</accession>
    <name>A0A7U8TRF4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdenum cofactor biosynthesis protein moeB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416855.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRF4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="300"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="392" mass="42173" checksum="06970A1BD2CC9645" modified="2021-06-02" version="1">MSTSLPPLVEPASALSREEVARYSRHLIIPDLGVDGQKRLKNARVLVIGAGGLGAPTLLYLAAAGVGTIGIVDFDVVDESNLQRQVIHGVADVGRSKAQSARDSIVAINPLIRVRLHELRLAPSNAVDLFKQYDLILDGTDNFATRYLVNDAAVLAGKPYVWGSIYRFEGQASVFWEDAPDGLGVNYRDLYPEPPPPGMVPSCAEGGVLGIICASVASVMGTEAIKLITGIGETLLGRLLVYDALEMSYRTITIRKDPSTPKITELVDYEQFCGVVADDAAQAAKGSTITPRELRDWLDSGRKLALIDVRDPVEWDIVHIDGAQLIPKSLINSGEGLAKLPQDRTAVLYCKTGVRSAEALAAVKKAGFSDAVHLQGGIVAWAKQMQPDMVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRF7</accession>
    <name>A0A7U8TRF7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismate synthase</fullName>
            <ecNumber evidence="3">5.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = isochorismate</text>
            <dbReference type="Rhea" id="RHEA:18985"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29780"/>
            <dbReference type="EC" id="5.4.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isochorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.4.2" evidence="3"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416879.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRF7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008909">
        <property type="term" value="F:isochorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004561">
        <property type="entry name" value="IsoChor_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00543">
        <property type="entry name" value="isochor_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="5">
        <location>
            <begin position="97"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="372" mass="38938" checksum="E2C1480BC281D8F3" modified="2021-06-02" version="1">MSAHVATLHPEPPFALCGPRGTLIARGVRTRYCDVRAAQAALRSGTAPILLGALPFDVSRPAALMVPDGVLRARKLPDWPTGPLPKVRVAAALPPPADYLTRIGRARDLLAAFDGPLHKVVLARAVQLTADAPLDARVLLRRLVVADPTAYGYLVDLTSAGNDDTGAALVGASPELLVARSGNRVMCKPFAGSAPRAADPKLDAANAAALASSAKNRHEHQLVVDTMRVALEPLCEDLTIPAQPQLNRTAAVWHLCTAITGRLRNISTTAIDLALALHPTPAVGGVPTKAATELIAELEGDRGFYAGAVGWCDGRGDGHWVVSIRCAQLSADRRAALAHAGGGIVAESDPDDELEETTTKFATILTALGVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRG9</accession>
    <name>A0A7U8TRG9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein LpqB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lpqB</name>
        <name evidence="7" type="ORF">TBLG_03882</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LpqB lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01373">
        <property type="entry name" value="LpqB_lipoprot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023959">
        <property type="entry name" value="Lipoprotein_LpqB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018910">
        <property type="entry name" value="Lipoprotein_LpqB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10647">
        <property type="entry name" value="Gmad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031126279" description="Lipoprotein LpqB" evidence="5">
        <location>
            <begin position="27"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="6">
        <location>
            <begin position="195"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="583" mass="61093" checksum="203E7FE34F3D040C" modified="2021-06-02" version="1">MRLTILLFLGAVLAGCASVPSTSAPQAIGTVERPVPSNLPKPSPGMDPDVLLREFLKATADPANRHLAARQFLTESASNAWDDAGSALLIDHVVFVETRSAEKVSVTMRADILGSLSDVGVFETAEGQLPDPGPIELVKTSGGWRIDRLPNGVFLDWQQFQETYKRNTLYFADPTGKTVVPDPRYVAVSDRDQLATELVSKLLAGPRPEMARTVRNLLAPPLRLRGPVTRADGGKSGIGRGYGGARVDMEKLSTTDPHSRQLLAAQIIWTLARADIRGPYVINADGAPLEDRFAEGWTTSDVAATDPGVADGAAAGLHALVNGSLVAMDAQRVTPVPGAFGRMPEQTAAAVSRSGRQVASVVTLGRGAPDEAASLWVGDLGGEAVQSADGHSLSRPSWSLDDAVWVVVDTNVVLRAIQDPASGQPARIPVDSTAVASRFPGAINDLQLSRDGTRAAMVIGGQVILAGVEQTQAGQFALTYPRRLGFGLGSSVVSLSWRTGDDIVVTRTDAAHPVSYVNLDGVNSDAPSRGLQTPLTAIAANPSTVYVAGPQGVLMYSASVESRPGWADVPGLMVPGAAPVLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRH0</accession>
    <name>A0A7U8TRH0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="7">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="7">EPSP synthase</shortName>
            <shortName evidence="7">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroA</name>
        <name evidence="10" type="ORF">TBLG_03861</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRH0"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EPSP_synthase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="7">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate-3-phosphate binding" evidence="7">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD14963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="450" mass="46426" checksum="27BB86F9412A07D5" modified="2021-06-02" version="1">MKTWPAPTAPTPVRATVTVPGSKSQTNRALVLAALAAAQGRGASTISGALRSRDTELMLDALQTLGLRVDGVGSELTVSGRIEPGPGARVDCGLAGTVLRFVPPLAALGSVPVTFDGDQQARGRPIAPLLDALRELGVAVDGTGLPFRVRGNGSLAGGTVAIDASASSQFVSGLLLSAASFTDGLTVQHTGSSLPSAPHIAMTAAMLRQAGVDIDDSTPNRWQVRPGPVAARRWDIEPDLTNAVAFLSAAVVSGGTVRITGWPRVSVQPADHILAILRQLNAVVIHADSSLEVRGPTGYDGFDVDLRAVGELTPSVAALAALASPGSVSRLSGIAHLRGHETDRLAALSTEINRLGGTCRETPDGLVITATPLRPGIWRAYADHRMAMAGAIIGLRVAGVEVDDIAATTKTLPEFPRLWAEMVGPGQGWGYPQPRSGQRARRATGQGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRH2</accession>
    <name>A0A7U8TRH2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="55" mass="6098" checksum="F7DEBDAD948B6F8C" modified="2021-06-02" version="1">MADGVWGEAGFEGTTTRIREPTSTREQTQKSPISGEIGDFCVCSPRAPRLTTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRH6</accession>
    <name>A0A7U8TRH6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="7" type="ORF">TBLG_03914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRH6"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="8"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="174" mass="17774" checksum="18CF4357E0CBC8D1" modified="2021-06-02" version="1">MTPAGERPRVGVIMGSDSDWPVMADAAAALAEFDIPAEVRVVSAHRTPEAMFSYARGAAERGLEVIIAGAGGAAHLPGMVAAATPLPVIGVPVPLGRLDGLDSLLSIVQMPAGVPVATVSIGGARNAGLLAVRMLGAANPQLRARIVAFQDRLADVVAAKDAELQRLAGKLTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRI8</accession>
    <name>A0A7U8TRI8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphomannomutase pmmA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRI8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="6">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="7">
        <location>
            <begin position="160"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="8">
        <location>
            <begin position="268"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="5">
        <location>
            <begin position="378"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD14997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="465" mass="49067" checksum="72BE3572CC9DDA10" modified="2021-06-02" version="1">MSWPAAAVDRVIKAYDVRGLVGEEIDESLVTDLGAAFARLMRTEDARPVVIGHDMRDSSPSLADAFAAGVTGQGLDVVRVGLASTDQLYFASGLLDCPGAMFTASHNPAAYNGIKMCRAAAKPVGADTGLTAIRDDLIAGVARYDGTPGTIADQDVLVDYGAFLRSLVDTSGLRPLRVAVDAGNGMAGHTAPAVLGVIDSITLLPLYFELDGSFPNHEANPLDPANLVDLQAYVRDTGADIGLAFDGDADRCFVVDERGQPVSPSTVTALVAARELNREIGATIIHNVITSRAVPELVAERGGTPLRSRVGHSYIKALMAETGAIFGGEHSAHYYFRDFWGADSGMLAALHVLAALGEQSRPLSELTADYQRYESSGEINFTVVDSSACVEAVLKSFGNRIVSIDHLDGVTVDLGDDSWFNLRSSNTEPLLRLNVEGRSVGDVDAVVRQVSAEIAAQSAHAKAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRK0</accession>
    <name>A0A7U8TRK0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase atsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009200">
        <property type="entry name" value="DUF1269_membrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06897">
        <property type="entry name" value="DUF1269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="212"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="970" mass="105649" checksum="8CA7DFD6D2F4C512" modified="2021-06-02" version="1">MMSEDNALVLVAGYQDLDSARHDFQTLVDAAKDKSIPLQGAVLIGKDAEGSPVLVDTGNRLGRRGAAWGAGVGLAIGLFSPALLASAALGAATGALAGTFAHHRIKTGLADKIGQALAAGRAVVIAVTEAQGRLEAGQALASSPMKSVAELSRSTLRSLGAALREAMGKFNPDRTRLPLPQRRFGGVVGRTMAESVGDWSIVPGPFPPDDAPNVLIVLIDDAGFGGPDTFGGAIRTPTLSRLAQNGLIYNRFHVTAVCSPTRAALLTGRNHHRVGFGSVCEFPGPYPGYSAVRPRSCAALPRILRDNGYVTGAFGKWHLTPDNVQGAAGPFDNWPLGWGFDHFWGFPSGAAGQYDPIISQDNSVIGIPEGSGEDGRPYYFPDDLTDKAIEWLHTVRAQNATKPWMLYYATGATHAPHHVFKEWADKYRGEFDDGWDVYRQKTFERQKRLGIIPPDAELTERPDLFPAWDSMSEAQKRLFARQMEVFAGFSENADWNVGRLLDAIEDLGESDNTLVFYIWGDNGASMEGTNTGSFNEMTFLNGLDLDAERQLELIEQYGGIAALGDEFTAPHFASAWAHASNTPLQWGKQMASHLGGTRDPLVVAWPARIRPDGRVRSQFTHCIDIAPTVLAAIGLPEPTHVDGFEQEPMDGTSFVRTFDDAEAEDRHTVQYFENFGSRAIYKDGWWACARLDKAPWDLSPETMRRFAPGTYDPDQDVWELYYLPDDFSQAKNLAAEHPDKVAELTQLWWPEAERNRVLPLLGGLAVMFGDLPPLPTTARFSFKGDVQNIQRGMVPRICGRSYAIEARLHIPDGGAQGVIVANADFMGGFALWVDEQRHLHHTYSFLGVETYRQVSSEPLPTGDVTVRMLFDSHQPVAASGGRVTLWADDRLIGEGELPQTVPLAFTSYAGMDIGRDNGLVVDRGYEDKAPYAFTGTVTEVIFDLKPVHPEAARALHEHASVQAVGQGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRM9</accession>
    <name>A0A7U8TRM9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thymidine phosphorylase deoA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03955</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900016.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRM9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004645">
        <property type="term" value="F:1,4-alpha-oligoglucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006206">
        <property type="term" value="P:pyrimidine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006213">
        <property type="term" value="P:pyrimidine nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036566">
        <property type="entry name" value="PYNP-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013102">
        <property type="entry name" value="PYNP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018090">
        <property type="entry name" value="Pyrmidine_PPas_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017872">
        <property type="entry name" value="Pyrmidine_PPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000053">
        <property type="entry name" value="Thymidine/pyrmidine_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10515">
        <property type="entry name" value="PTHR10515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07831">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000478">
        <property type="entry name" value="TP_PyNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00941">
        <property type="entry name" value="PYNP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54680">
        <property type="entry name" value="SSF54680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02644">
        <property type="entry name" value="Y_phosphoryl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00647">
        <property type="entry name" value="THYMID_PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PYNP_C" evidence="5">
        <location>
            <begin position="338"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="427" mass="44486" checksum="2253269754A96D60" modified="2021-06-02" version="1">MTDFAFDAPTVIRTKRDGGRLSDAAIDWVVKAYTDGRVADEQMSALLMAIVWRGMDRGEIARWTAAMLASGARLDFTDLPLATVDKHSTGGVGDKITLPLVPVVAACGGAVPQASGRGLGHTGGTLDKLESITGFTANLSNQRVREQLCDVGAAIFAAGQLAPADAKLYALRDITGTVESLPLIASSIMSKKLAEGAGALVLDVKVGSGAFMRSPVQARELAHTMVELGAAHGVPTRALLTEMNCPLGRTVGNALEVAEALEVLAGGGPPDVVELTLRLAGEMLELAGIHGRDPAQTLRDGTAMDRFRRLVAAQGGDLSKPLPIGSHSETVTAGASGTMGDIDAMAVGLAAWRLGAGRSRPGARVQHGAGVRIHRRPGEPVVVGEPLFTLYTNAPERFGAARAELAGGWSIRDSPPQVRPLIVDRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN9</accession>
    <name>A0A7U8TRN9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multifunctional geranylgeranyl pyrophosphate synthetase idsA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_04002</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417957.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRN9"/>
    <dbReference type="UniPathway" id="UPA00163"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="359" mass="38852" checksum="F59F229B19432E6E" modified="2021-06-02" version="1">MRGTDEKYGLPPQPDSDRMTRRTLPVLGLAHELITPTLRQMADRLDPHMRPVVSYHLGWSDERGRPVNNNCGKAIRPALVFVAAEAAGADPHSAIPGAVSVELVHNFSLVHDDLMDRDEHRRHRPTVWALWGDAMALLAGDAMLSLAHEVLLDCDSPHVGAALRAISEATRELIRGQAADTAFESRTDVALDECLKMAEGKTAALMAASAEVGALLAGAPRSVREALVAYGRHIGLAFQLVDDLLGIWGRPEITGKPVYSDLRSRKKTLPVTWTVAHGGSAGRRLAAWLVDETGSQTASDDELAAVAELIECGGGRRWASAEARRHVTQGIDMVARIGIPDRPAAELQDLAHYIVDRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRQ7</accession>
    <name>A0A7U8TRQ7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417980.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRQ7"/>
    <dbReference type="GeneID" id="45427400"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040660">
        <property type="entry name" value="N_formyltrans_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18216">
        <property type="entry name" value="N_formyltrans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="56"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="N_formyltrans_C" evidence="2">
        <location>
            <begin position="177"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="234" mass="26515" checksum="63FF857BB6FFAA8F" modified="2021-06-02" version="1">MTILILTDNVHAHALAVDLQARHGDMDVYQSPIGQLPGVPRCDVAERVAEIVERYDLVLSFHCKQRFPAALIDGVRCVNVHPGFNPYNRGWFPQVFSIIDGQKVGVTIHEIDDQLDHGPIIAQRECAIESWDSSGSVYARLMDIERELVLEHFDAIRDGSYTAKSPATEGNLNLKKDFEQLRRLDLNERGTFGHFLNRLRALTHDDFRNAWFVDASGRKVFVRVVLEPEKPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRR9</accession>
    <name>A0A7U8TRR9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin cofactor biosynthesis protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mob_synth_C" evidence="1">
        <location>
            <begin position="47"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="203" mass="22570" checksum="ECB5B3E4FFB1751F" modified="2021-06-02" version="1">NYKVIEGIEAVAAAGFTDTKLDSVVIRGFNDDELSDLIEFARNVNAEVRFIEYMDVGGATQWSMDKVFTKAQMLSTLGKKYGPIAALPKYDSAPANRYRLPDGTTFGIIASTTEPFCATCDRSRLTADGIWLHCLYALSGINLRESVRAGASANDVVQILQRGWRDRANRGAEQRLAQRTRQVFLPVSRLKRDPHLEMHTRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRW9</accession>
    <name>A0A7U8TRW9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_04118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="5"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418610.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRW9"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01221">
        <property type="entry name" value="rmlC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="4">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="202" mass="22314" checksum="A6A1AFA0FC0F5871" modified="2021-06-02" version="1">MKARELDVPGAWEITPTIHVDSRGLFFEWLTDHGFRAFAGHSLDVRQVNCSVSSAGVLRGLHFAQLPPSQAKYVTCVSGSVFDVVVDIREGSPTFGRWDSVLLDDQDRRTIYVSEGLAHGFLALQDNSTVMYLCSAEYNPQREHTICATDPTLAVDWPLVDGAAPSLSDRDAAAPSFEDVRASGLLPRWEQTQRFIGEMRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRY2</accession>
    <name>A0A7U8TRY2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418781.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRY2"/>
    <dbReference type="GeneID" id="45427463"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031092332" evidence="1">
        <location>
            <begin position="32"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="98" mass="9795" checksum="BCA07F382F9F94CD" modified="2021-06-02" version="1">MSFTAQPEMLAAAAGELRSLGATLKASNAAAAVPTTGVVPPAADEVSLLLATQFRTHAATYQTASAKAAVIHEQFVTTLATSASSYADTEAANAVVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRZ6</accession>
    <name>A0A7U8TRZ6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein mce4F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418963.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRZ6"/>
    <dbReference type="GeneID" id="45427480"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="39"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="564" mass="59637" checksum="37752501FE15EC6F" modified="2021-06-02" version="1">MIDRLAKIQLSIFAVITVITLSVMAIFYLRLPATFGIGTYGVSADFVAGGGLYKNANVTYRGVAVGRVESVGLNPNGVTAHMRLNSGTAIPSNVTATVRSVSAIGEQYIDLVPPENPSSTKLRNGFRIQRQNTRIGQDVADLLRQAETLLGSLGDTRLRELLHEAFIATNGAGPELARLIESARLLVDEANANYPQVSQLIDQAGPFLQAQIRAGGDIKSLADGLARFTWQLRAADPRLRDTLADAPDAIDEANTAFSGIRPSFPALAASLANLGRVGVIYHKSIEQLLVVFPALFAAIITSAGGVPQDEGAKLDFKIDLHDPPPCMTGFLPPPLVRSPADESVREIPRDMYCKTAQNDPSTVRGARNYPCQEFPGKRAPTVQLCRDPRGYVPVGTNPWRGPPIPYGTEVTDGRNILPPNKFPYIPPGADPDPGVPIVGPPPPGQVAGPGPAPHQPAQPAPPPNDNGPPPPFTSWMPPGYPPEPPQVPYPATIPPPPPPEGTGPPPGPAPGPQPQASGPAYTIYDQLSGAFADPAGGTGIFAPGMTGASSAENWVDLMRDPRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT35</accession>
    <name>A0A7U8TT35_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03864</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416922.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT35"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="6">
        <location>
            <begin position="58"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="5">
        <location>
            <begin position="299"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="380" mass="40795" checksum="1A7D0B80E1C3A045" modified="2021-06-02" version="1">MSKKHTTLNASIIDTRRPTVAGADRHPGWHALRKIAARITTPLLPDDYLHLANPLWSARELRGRILGVRRETEDSATLFIKPGWGFSFDYQPGQYIGIGLLVDGRWRWRSYSLTSSPAASGSARMVTVTVKAMPEGFLSTHLVAGVKPGTIVRLAAPQGNFVLPDPAPPLILFLTAGSGITPVMSMLRTLVRRNQITDVVHLHSAPTAADVMFGAELAALAADHPGYRLSVRETRAQGRLDLTRIGQQVPDWRERQTWACGPEGVLNQADKVWSSAGASDRLHLERFAVSKTAPAGAGGTVTFARSGKSVAADAATSLMDAGEGAGVQLPFGCRMGICQSCVVDLVEGHVRDLRTGQRHEPGTRVQTCVSAASGDCVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT92</accession>
    <name>A0A7U8TT92_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Adenosine deaminase</fullName>
            <ecNumber evidence="1 3">3.5.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2 3">Adenosine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">add</name>
        <name evidence="5" type="ORF">TBLG_03954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-deoxyadenosine + H(+) + H2O = 2'-deoxyinosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:28190"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17256"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:28997"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="1 3"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417259.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT92"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00540">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028893">
        <property type="entry name" value="A_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="PTHR11409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="A_deaminase" evidence="4">
        <location>
            <begin position="14"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00031852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="365" mass="39743" checksum="C034CDCEC377BB29" modified="2021-06-02" version="1">MTAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLPATDVDALASWFRTQSHSGSLERYLEPFSHTVAVMQTPEALYRVAFECAQDLAADSVVYAEVRFAPELHISCGLSFDDVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSREIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDIDVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGAVASIAEHPFDLLARARFRVTVNTDNRLMSDTSMSLEMHRLVEAFGYGWSDLARFTVNAMKSAFIPFDQRLAIIDEVIKPRFAALMGHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTA0</accession>
    <name>A0A7U8TTA0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTA0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="160" mass="18157" checksum="28D77A7E4BD620D5" modified="2021-06-02" version="1">MSVALLREMFDRMVVAKNAELIEHYYDPDFLMYSDGLSQSFAKFRDSHRKLYATAISYAVEYDEHAWVEAQTRLPGGCGSPRRDLARSRPASRWYSLPPTATAEFTGSGRRRGRVGATWPPSTITETTTDRLAMRNQLRAGAATLLFCDPMLQRFPATRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTD0</accession>
    <name>A0A7U8TTD0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HrpA-like helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="120" mass="11821" checksum="3B465C06144EC825" modified="2021-06-02" version="1">MGVRVGTVVGPVPGGATVVTVSGGSCGRKVLGEGWGDVLVGAVGRGEVDITVRGAGAPTMALVDVLSPLLIMTAVATAPSATTLPRIAATGRHRRSAAQANSPSEQVRPAPKPLELSSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTH7</accession>
    <name>A0A7U8TTH7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="159" mass="17338" checksum="8E245B4D2F96D8ED" modified="2021-06-02" version="1">MASDAGEHDGVAVLLKAVTWRALDRDPRHRCGCLVRFDRRHDVVSQRRCSLGGDQGMGALRSQIQRTTPEPLAEAHPQAFDPAPVVGMGACRRNQRMVIVASGARPARAHAVRCRWLFSSGNSFPQAAIQRYGLTEIRLVTIARTAGGSHVPSVNLLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTK7</accession>
    <name>A0A7U8TTK7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infA</name>
        <name evidence="5" type="ORF">TBLG_04115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418601.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTK7"/>
    <dbReference type="GeneID" id="64259827"/>
    <dbReference type="GeneID" id="66969202"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S1-like" evidence="4">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="73" mass="8489" checksum="70CEB2A79E874448" modified="2021-06-02" version="1">MAKKDGAIEVEGRVVEPLPNAMFRIELENGHKVLAHISGKMRQHYIRILPEDRVVVELSPYDLSRGRIVYRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTZ6</accession>
    <name>A0A7U8TTZ6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417264.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTZ6"/>
    <dbReference type="GeneID" id="45427315"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="133" mass="14072" checksum="B21C0B188CB8080E" modified="2021-06-02" version="1">MPDVDWNMLRGNATQAAAGAYVPYSRFAVGAAALVDDGRVVTGCNVENVSYGLTLCAECAVVCALHSTGGGRLLALACVDGHGSVLMPCGRCRQVLLEHGGSELLIDHPVRPRRLGDLLPDAFGLDDLPRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y280</accession>
    <name>A0A7U8Y280_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02929</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403974.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="46" mass="4842" checksum="163B371565B99A53" modified="2021-06-02" version="1">MAALRDPNARANPAGAELATWSLVHGFSTLWLDDAVNADVKQTSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2B5</accession>
    <name>A0A7U8Y2B5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="325" mass="36102" checksum="A8362353951A42C3" modified="2021-06-02" version="1">MRTEDDSWDVTTSVGSTGLLVAAARVLETQKADPLAIDPYAEVFCRAAGGEWADVLDGKLPDHYLTTGDFGEHFVNFQGARTRYFDEYFSRATAAGMKQVVILAAGLDSRAFRLQWPIGTTIFELDRPQVLDFKNAVLADYHIRPRAQRRSVAVDLRDEWQIALCNNGFDANRPSAWIAEGLLVYLSAEAQQRLFIGIDTLASPGSHVAVEEATPLDPCEFAAKLERERAANAQGDPRRFFQMVYNERWARATEWFDERGWRATATPLAEYLRRVGRAVPEADTEAAPMVTAITFVSAVRTGLVADPARTSPSSTSIGFKRFEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2D6</accession>
    <name>A0A7U8Y2D6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005751">
        <property type="entry name" value="ATP-dep_DNA_helicase_PcrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01073">
        <property type="entry name" value="pcrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="312"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="769" mass="84966" checksum="D18F3B29E04ABB3D" modified="2021-06-02" version="1">MSVHATDAKPPGPSPADQLLDGLNPQQRQAVVHEGSPLLIVAGAGSGKTAVLTRRIAYLMAARGVGVGQILAITFTNKAAAEMRERVVGLVGEKARYMWVSTFHSTCVRILRNQAALIEGLNSNFSIYDADDSRRLLQMVGRDLGLDIKRYSPRLLANAISNLKNELIDPHQALAGLTEDSDDLARAVASVYDEYQRRLRAANALDFDDLIGETVAVLQAFPQIAQYYRRRFRHVLVDEYQDTNHAQYVLVRELVGRDSNDGIPPGELCVVGDADQSIYAFRGATIRNIEDFERDYPDTRTILLEQNYRSTQNILSAANSVIARNAGRREKRLWTDAGAGELIVGYVADNEHDEARFVAEEIDALAEGSEITYNDVAVFYRTNNSSRSLEEVLIRAGIPYKVVGGVRFYERKEIRDIVAYLRVLDNPGDAVSLRRILNTPRRGIGDRAEACVAVYAENTGVGFGDALVAAAQGKVPMLNTRAEKAIAGFVEMFDELRGRLDDDLGELVEAVLERTGYRRELEASTDPQELARLDNLNELVSVAHEFSTDRDGPRWTSEAGRPDTGVLADFLERVSLVADADEIPEHGAGVVTLMTLHTAKGLEFPVVFVTGWEDGMFPHMRALDNPTELSEERRLAYVGITRARQRLYVSRAIVRSSWGQPMLNPESRFLREIPQELIDWRRTAPKPSFSAPVSGAGRFGSARPSPTRSGASRRPLLVLQVGDRVTHDKYGLGRVEEVSGVGESAMSLIDFGSSGRVKLMHNHAPVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y302</accession>
    <name>A0A7U8Y302_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="1">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>9-ribosyl-trans-zeatin 5'-phosphate + H2O = D-ribose 5-phosphate + trans-zeatin</text>
            <dbReference type="Rhea" id="RHEA:48564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16522"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:87947"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + N(6)-(dimethylallyl)adenosine 5'-phosphate = D-ribose 5-phosphate + N(6)-dimethylallyladenine</text>
            <dbReference type="Rhea" id="RHEA:48560"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17660"/>
            <dbReference type="ChEBI" id="CHEBI:57526"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="EC" id="3.2.2.n1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="1"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898770.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y302"/>
    <dbReference type="GeneID" id="45425175"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="187" mass="20014" checksum="892D09FFD6935D23" modified="2021-06-02" version="1">MSAKIDITGDWTVAVYCAASPTHAELLELAAEVGAAIAGRGWTLVWGGGHVSAMGAVASAARACGGWTVGVIPKMLVYRELADHDADELIVTDTMWERKQIMEDRSDAFIVLPGGVGTLDELFDAWTDGYLGTHDKPIVMVDPWGHFDGLRAWLNGLLDTGYVSPTAMERLVVVDNVKDALRACAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y392</accession>
    <name>A0A7U8Y392_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901140.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y392"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022171">
        <property type="entry name" value="PPE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12484">
        <property type="entry name" value="PPE-SVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-SVP" evidence="3">
        <location>
            <begin position="309"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="396" mass="40016" checksum="6AFAE0D7B5F668D0" modified="2021-06-02" version="1">MVDFGALPPEINSARMYAGPGSASLVAAAKMWDSVASDLFSAASAFQSVVWGLTTGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAATAATATEALLPFEDAPLITNPGGLLEQAVAVEEAIDTAAANQLMNNVPQALQQLAQPTKSIWPFDQLSELWKAISPHLSPLSNIVSMLNNHVSMTNSGVSMASTLHSMLKGFAPAAAQAVETAAQNGVQAMSSLGSQLGSSLGSSGLGAGVAANLGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAQTAPGHMLGGLPLGQLTNSGGGFGGVSNALRMPPRAYVMPRVPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y469</accession>
    <name>A0A7U8Y469_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">D-3-phosphoglycerate dehydrogenase serA2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02872</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y469"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="2">
        <location>
            <begin position="43"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="3">
        <location>
            <begin position="115"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="326" mass="34420" checksum="6616132C8B89BB5A" modified="2021-06-02" version="1">MTPRPRALVTAPLRGPGFAQLRRLADVVYDPWIDQRPLRIYSAEQLADRITAVAADVLVVESDSVGGPVFERGLRVVAATRGDPSNVDIPGATAAGIPVLHTPARNADAVAEMTVALLLAVARHLIPADADVRSGNIFRDGTIPYQRFRGAEIAGLTAGLVGLGAVGRAVRWRLSGLGLRVIAHDPYRDDAGHSLDELLAEADIVSMHAAVTDDTIGMIGAQQFAAMRDGAVFLNTARSQLHDTDALVDALRGGKLAAAGLDHFTGEWLPTDHPLVSMPNVVLTPHIGGATWNTEARQARMVADDLGALLSGNRPAHVVNPEVLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y485</accession>
    <name>A0A7U8Y485_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">5'-methylthioadenosine phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="142" mass="15464" checksum="7E73CD7E2C11E16F" modified="2021-06-02" version="1">MHNNGRMLGVIGGSGFYTFFGSDTRTVNSDTPYGQPSAPITIGTIGVHDVAFLPRHGAHHQYSAHAVPYRANMWALRALWCAAGLRAVCGRAAWTLNSSPARSWCPISWVDRTSGRADTYFDFGRCPCPPSPIRTAPRCGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y497</accession>
    <name>A0A7U8Y497_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="245" mass="21029" checksum="41D35508EA712644" modified="2021-06-02" version="1">MRARRRRRCGRQRRHAANLSADGQAGGNGENGGAGGTGRVGGPVGGHGLLGLGGSHGAGGAGGSGGDGGAPGDGGNGATGTWGHNLGAGGTGGNGGNPGAGGAGGAGGASVGGSAHGANGAPGTTSTSGGNGGDGGKGADAISSGQTGANGGRGGDGGQVGNGGAGGAGGRGGAGGLGFGSEAPGRPGGAGGTGGAGGNGGTQAGDGGTGGAGGAGGDGGSGGAGSIGFNASSSRGRRLTRREWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4A3</accession>
    <name>A0A7U8Y4A3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026349">
        <property type="entry name" value="CHP04255"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04255">
        <property type="entry name" value="sporadTIGR04255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="271" mass="30219" checksum="A6E873B2DF811848" modified="2021-06-02" version="1">MLPETNQDEVQPNAPVALVTVEIRHPTTDSLTESANRELKHLLINDLPIERQAQDVSWGMTAPGGAPTPVADRFVRYVNRDNTTAASLKNQAIVVETTAYRSFEAFTDVVMRVVDARAQVSSIVGLERIGLRFVLEIRVPAGVDGRIMWSNWIDEQLLGPQRFTPGGLVLTEWQGAAVYRELQPGKSLIVRYGPGMGQALDPNYHLRRITPAQTGPFFLLDIDSFWTPSGGSIPEYNRDALVSTFQDLYGPAQVVFQEMITSRLKDELLRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4E3</accession>
    <name>A0A7U8Y4E3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpsJ</name>
        <name evidence="6" type="ORF">TBLG_02844</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403578.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4E3"/>
    <dbReference type="GeneID" id="64259772"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="7"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="101" mass="11431" checksum="2B254B54B7DE0DF5" modified="2021-06-02" version="1">MAGQKIRIRLKAYDHEAIDASARKIVETVVRTGASVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDIIDPTPKTVDALMRIDLPASVDVNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4E9</accession>
    <name>A0A7U8Y4E9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rplX</name>
        <name evidence="6" type="ORF">TBLG_02859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="3">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403654.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4E9"/>
    <dbReference type="GeneID" id="45424680"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005825">
        <property type="entry name" value="Ribosomal_L24/26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01108">
        <property type="entry name" value="RIBOSOMAL_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="105" mass="11475" checksum="20AC100C291EC319" modified="2021-06-02" version="1">MKVHKGDTVLVISGKDKGAKGKVLQAYPDRNRVLVEGVNRIKKHTAISTTQRGARSGGIVTQEAPIHVSNVMVVDSDGKPTRIGYRVDEETGKRVRISKRNGKDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4J1</accession>
    <name>A0A7U8Y4J1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Collagen like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0176">Collagen</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="272" mass="24229" checksum="7CE0CF421890D415" modified="2021-06-02" version="1">MSEVPAGPVETPRSRVSSEGPVGQAGLPCCSVPVGPAGPGVPAVPAQLVGPVAPVGPAGCSPAAAAAGSAGSHRRAPVGPAAPVGLVGCSPAAGSAVLAGEPGPAVPVGLVGRVGPEGCSLAAALAGPAGPAVPVGLVGRVGPAGCSEPVALAGSAGKATTPAGTVGPVAAPACSPLATAALAGPAGPLPPEPAGPAGRVARPACCSAPVGPVGPVGLPAPSVTPVTPAGPVGRVARPACCSAPVGPVGPAALGASPTALPAVPAGPAAGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4J9</accession>
    <name>A0A7U8Y4J9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cellulase celA2a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4J9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="34" mass="3490" checksum="8A581D989094293B" modified="2021-06-02" version="1">MNGAAPTNGAPLSYPSICEGVHWGHLVGGHQPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4P9</accession>
    <name>A0A7U8Y4P9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mycobacterial persistence regulator mprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4P9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="129"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="230" mass="25924" checksum="C35D0734555BFC1C" modified="2021-06-02" version="1">MSVRILVVDDDRAVRESLRRSLSFNGYSVELAHDGVEALDMIASDRPDALVLDVMMPRLDGLEVCRQLRSTGDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARMRALLRRTKPEDAAESMAMRFSDLTLDPVTREVNRGQRRISLTRTEFALLEMLIANPRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEADGEPRLIHTVRGVGYVLRETPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4T8</accession>
    <name>A0A7U8Y4T8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine N-acyltransferase MbtK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Mycobactin synthase protein K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03532</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acyltransferase required for the direct transfer of medium- to long-chain fatty acyl moieties from a carrier protein (MbtL) on to the epsilon-amino group of lysine residue in the mycobactin core.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis; mycobactin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4T8"/>
    <dbReference type="UniPathway" id="UPA00011"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019290">
        <property type="term" value="P:siderophore biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019432">
        <property type="entry name" value="Acyltransferase_MbtK/IucB-like"/>
    </dbReference>
    <dbReference type="SMART" id="SM01006">
        <property type="entry name" value="AlcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlcB" evidence="5">
        <location>
            <begin position="46"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="210" mass="23799" checksum="2ADDBB5D0BE81561" modified="2021-06-02" version="1">MTKPTSAGQADDALVRLARERFDLPDQVRRLARPPVPSLEPPYGLRVAQLTDAEMLAEWMNRPHLAAAWEYDWPASRWRQHLNAQLEGTYSLPLIGSWHGTDGGYLELYWAAKDLISHYYDADPYDLGLHAAIADLSKVNRGFGPLLLPRIVASVFANEPRCRRIMFDPDHRNTATRRLCEWAGCKFLGEHDTTNRRMALYALEAPTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y507</accession>
    <name>A0A7U8Y507_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898830.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y507"/>
    <dbReference type="GeneID" id="45425312"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="146" mass="16530" checksum="333945ED84CF2D5E" modified="2021-06-02" version="1">MLLRKGTVYVLVIRADLVNAMVAHARRDHPDEACGVLAGPEGSDRPERHIPMTNAERSPTFYRLDSGEQLKVWRAMEDADEVPVVIYHSHTATEAYPSRTDVKLATEPDAHYVLVSTRDPHRHELRSYRIVDGAVTEEPVNVVEQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7H7</accession>
    <name>A0A7U8Y7H7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416891.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7H7"/>
    <dbReference type="GeneID" id="45427215"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024020">
        <property type="entry name" value="Anit_sigma_mycothiol_RsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014295">
        <property type="entry name" value="Anti-sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027383">
        <property type="entry name" value="Znf_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13490">
        <property type="entry name" value="zf-HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02949">
        <property type="entry name" value="anti_SigH_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03988">
        <property type="entry name" value="antisig_RsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-HC2" evidence="1">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="101" mass="11290" checksum="36636191A0D86341" modified="2021-06-02" version="1">MSENCGPTDAHADHDDSHGGMGCAEVIAEVWTLLDGECTPETRERLRRHLEACPGCLRHYGLEERIKALIGTKCRGDRAPEGLRERLRLEIRRTTIIRGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y837</accession>
    <name>A0A7U8Y837_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-regulated short-chain dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416899.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="282" mass="29814" checksum="C143553EC2E24432" modified="2021-06-02" version="1">MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPILLEKKWLRPTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKPEVYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y880</accession>
    <name>A0A7U8Y880_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cholesterol oxidase choD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418002.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y880"/>
    <dbReference type="GeneID" id="45427405"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMC_oxred_C" evidence="2">
        <location>
            <begin position="468"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="578" mass="63024" checksum="E72695DF493397C5" modified="2021-06-02" version="1">MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRRFSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLNYANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDADRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPARTGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFERRSDGLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMRDRGRLPGLSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEPVRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLNPRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIPIGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDPYHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRRPPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVSNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9X0</accession>
    <name>A0A7U8Y9X0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNHc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416051.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003870">
        <property type="entry name" value="DUF222"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02720">
        <property type="entry name" value="DUF222"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="314"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="424" mass="44950" checksum="67E952DDD7AB0201" modified="2021-06-02" version="1">MFETLTAIDPDAEEAALIERIAELERLKSAAAAGQARAAAAVDAARRAAEGAAGVPAARRGRGLASEIALARRDSPARGSRHLGFAKALVYEMPHTLAALDCGALSEWRATLIVRESACLDVADRRALDAELCGDPGDLEGMGDARVVAAARAIAYRLDPQAVVDRAANAENDRTVTIRPAPDTMTYLTALLPVAQGVSVYAALTRAADTRCDGRSRGQVMADTLVERVTGRDAAVPTPIAVNLVMSDETLLGAANTPAQLCGYGPIPAAVARTMVASAVTDQRSRATLRRLYAHPQAGALVSMESRARLFPRGLAAFIELRDQRCRTPYCDAPIRHRDHAHPWADGGPTSAHNGLGTCERCNYAKQAPGWRVSTSVDENHTHTAEFITPTGSRHRSGAPPHLPAVTVSELEVRIGIALARYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA10</accession>
    <name>A0A7U8YA10_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name evidence="4" type="ORF">TBLG_03767</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416420.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA10"/>
    <dbReference type="GeneID" id="45427133"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 2" id="KW-0408">Iron</keyword>
    <keyword evidence="1 2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1278">Translocase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="3">
        <location>
            <begin position="37"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="184" mass="20219" checksum="9E8C05D2A8BC18A0" modified="2021-06-02" version="1">MGLEEQLPGGILLSTVEKVAGYVRKNSLWPATFGLACCAIEMMATAGPRFDIARFGMERFSATPRQADLMIVAGRVSQKMAPVLRQIYDQMAEPKWVLAMGVCASSGGMFNNYAIVQGVDHVVPVDIYLPGCPPRPEMLLHAILKLHEKIQQMPLGINRERAIAEAEEAALLARPTIEMRGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA17</accession>
    <name>A0A7U8YA17_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031353918" evidence="3">
        <location>
            <begin position="32"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="PPE" evidence="4">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="629" mass="60618" checksum="BE4DA60150F9434B" modified="2021-06-02" version="1">MLPPEINSLRMFTGAGSAPMLAASVAWDGLAAELAVAASSFGSVTSGLAGQSWQGAAAAAMAAAAAPYAGWLAAAAARAAGASAQAKAVASAFEAARAATVHPMLVAANRNAFVQLVLSNLFGQNAPAIAAAEAMYEQMWAADVAAMVGYHGGASAAAAALPSWQQALRGLPGLGQVASAISGGAASMFAAPAAATAAVTPPALNTGLGNIGSWNLGGGNVGLLNLGSGNFGSLNLGGGNTGNANLGGGNWGFANLGSGNIGNTNFGNGNQGNLNFGSGNLLGNGNFGFGNAFGDGNLGSGNVGSTNLGSGNFGSFNVGSGNMGMSNIGFGNLGNNNLGFGNNGNKNIGFGLTGDNLVGIGALNSGIGNMGFGNSGNNNIGFFNSGNGNVGFFNSGDGNTGFGNAGDVNTGFWNGGPFNTGFGNGGNTNFGFGNAGFQNMGHGNAGGVNVGSGNAGLANTGDFNSGGVVSGIGGNTGSFNSGNLNTGFGNAGDLNTGLFNSGDVNTGIGSTVDQPGSVSGFGNTGTSVSGFNNSGNLTSGFGNMNSNVFDSTSGFQNIGDANVGFFNSGNSNEGFFNTGMFNNGIYNSGVASTGIANSGNASSGVANSGDNSSGAFNQGDNQAGFFGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA52</accession>
    <name>A0A7U8YA52_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901572.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA52"/>
    <dbReference type="GeneID" id="45427206"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="5"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="266" mass="28576" checksum="49BACF4E0ECC2116" modified="2021-06-02" version="1">MTDTRVLAVANQKGGVAKTTTVASLGAAMVEKGRRVLLVDLDPQGCLTFSLGQDPDKLPVSVHEVLLGEVEPNAVLVTTMEGMTLLPANIDLAGAEAMLLMRAGREYALKRALAKFSDRFDVVIIDCPPSLGVLTLNGLTAADEAIVPLQCEMLAHRGVGQFLRTVADVQQITNPNLRLLGALPTLYDSRTTHTRDVLLDVADRYDLQVLAPPIPRTVRFAEASASGSSVMAGRKNKGAVAYRELAQALLKHWKTGRPLPTFTVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA55</accession>
    <name>A0A7U8YA55_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, tetR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417042.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA55"/>
    <dbReference type="GeneID" id="45427243"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040611">
        <property type="entry name" value="TetR_C_35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18556">
        <property type="entry name" value="TetR_C_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="211" mass="22800" checksum="932634693A18739F" modified="2021-06-02" version="1">MSTPSATVAPVKRIPYAEASRALLRDSVLDAMRDLLLTRDWSAITLSDVARAAGISRQTIYNEFGSRQGLAQGYALRLADRLVDNVHASLDANVGNFYEAFLQGFRSFFAESAADPLVISLLTGVAKPDLLQLITTDSAPIITRASARLAPAFTDTWVATTDNDANVLSRAIVRLCLSYVSMPPEADHDVAADLARLITPFAERHGVINVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA76</accession>
    <name>A0A7U8YA76_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417187.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA76"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="PTHR43521"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="21"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="494" mass="51344" checksum="03E3D51D1FBD74E7" modified="2021-06-02" version="1">MLEACQAIGVTAALGEPGEHSLPASTPITGDVLFSIAPTTPEQADHAIAAAAATFTAWRSTPAPVRGALVARLGELLTAHQQDLATLVTVEVGKITAEARGEVQEMIDVCQFSVGLSRQLYGRTIASERAGHRLLETWHPLGVVGVITAFNFPVAVWAWNTAVALVCGDTVVWKPSELTPLTALACQALLSRAAADVGAPAAVGGLLLGGAERGAQLVDDPRVALLSATGSVRMGQQVGPRVARRFGRVLLELGGNNAAIVAPSADLELAVRGIVFAAAGTAGQRCTSLRRLIVHRSVADDVVARVVGAYRQLAIGDPSAPDTLVGPLIHEAAYRDMVAALERARTDGGEVIGGDRREVGSPGAYYVAPAVVRMPSQTAIVATETFAPILYVLTYDDLDEAIALNNAVPQGLSSSIFTTDLREAEHFLDQSDCGIANVNIGTSGAEIGGAFGGEKQTGGGRESGSDAWKAYMRRATNTVNYSSELPLAQGVKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAB2</accession>
    <name>A0A7U8YAB2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="PFTB_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SQHop_cyclase_C" evidence="2">
        <location>
            <begin position="338"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="501" mass="55289" checksum="E9BB9F76EE30207A" modified="2021-06-02" version="1">METFRTLLAKAALGNGISSTAYDTAWVAKLGQLDDELSDLALNWLCERQLPDGSWGAEFPFCYEDRLLSTLAAMISLTSNKHRRRRAAQVEKGLLALKNLTSGAFEGPQLDIKDATVGFELIAPTLMAEAARLGLAICHEESILGELVGVREQKLRKLGGSKINKHITAAFSVELAGQDGVGMLDVDNLQETNGLVKYSPSASAYFALHVKPGDKRALAYISSIIQAGDGGAPAFYQAEIFEIVWSLWNLSRTDIDLSDPEIVRTYLPYLDHVEQHWVRGRGVGWTGNSTLEDCDTTSVAYDVLSKFGRSPDIGAVLQFEDADWFRTYFHEVGPSISTNVHVLGALKQAGYDKCHPRVRKVLEFIRSSKEPGRFCWRDKWHRSAYYTTAHLICAASNYDDALCSDAIGWILNTQRPDGSWGFFDGQATAEETAYCIQALAHWQRHSGTSLSAQISRAGGWLSQHCEPPYAPLWIAKTLYCSATVVKAAILSALRLVDESNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF19</accession>
    <name>A0A7U8TF19_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402870.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="477" mass="50203" checksum="D24E02A377F94DEA" modified="2021-06-02" version="1">MGLSSDDTRRREVVRDLAAGALLIGALFFPWNLYFGFRIPDSSKTVFGLLLAVTSLSLASLAVTFAGRRSQLRLGLNVPYLLLVLAFVVFDAIQTIRLGGTVHVPGGVGPGGWLGITGALLSAQPALTGATTDEGSHSRWLRATQFLGYASMLGAALSTGFNLSWRVRYALEPAAGASGFGKQNLAVIDTAVVYGVVALAAVLVASRWLLRPTAAEALSTVALGGSTLIAGSIVWSLPIGREIDAFHGIAQNTSTAGVGYEGYLVWAAAAAMCAPLTLFRSPNAPPIDKTVWRAASRNGLLLIAVWCLGSVAMRLTDLVVAVLLNYPFSRYDSMALAAFDLATAVLAIWLRFNMATEALPARLISSLCGLLCTFTVSRVIVGVVLAPRFQASSGGSAHPVYGNDLAQQITSTFDVVLCGLALSILAAAIVIGRLRQLPQPPHTPALSRPAGSPRIFRSAGSTHPVRPKIYRPPDHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF35</accession>
    <name>A0A7U8TF35_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mannosyltransferase pimB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02685</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF35"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901576">
        <property type="term" value="P:organic substance biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="3">
        <location>
            <begin position="202"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="378" mass="41238" checksum="E1E5524A88A52D65" modified="2021-06-02" version="1">MCGVRVAIVAESFLPQVNGVSNSVVKVLEHLRRTGHEALVIAPDTPPGEDRAERLHDGVRVHRVPSRMFPKVTTLPLGVPTFRMLRALRGFDPDVVHLASPALLGYGGLHAARRLGVPTVAVYQTDVPGFASSYGIPMTARAAWAWFRHLHRLADRTLAPSTATMESLIAQGIPRVHRWARGVDVQRFAPSARNEVLRRRWSPDGKPIVGFVGRLAPEKHVDRLTGLAASGAVRLVIVGDGIDRARLQSAMPTAVFTGARYGKELAEAYASMDVFVHSGEHETFCQVVQEALASGLPVIAPDAGGPRDLITPHRTGLLLPVGEFEHRLPDAVAHLVHERQRYALAARRSVLGRSWPVVCDELLGHYEAVRGRRTTQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF69</accession>
    <name>A0A7U8TF69_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein lpqN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403052.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF69"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019674">
        <property type="entry name" value="Lipoprotein_LpqN/LpqT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10738">
        <property type="entry name" value="Lpp-LpqN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031528236" evidence="2">
        <location>
            <begin position="30"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="228" mass="23682" checksum="1F0821C9E9947526" modified="2021-06-02" version="1">MKHFTAAVATVALSLALAGCSFNIKTDSAPTTSPTTTSPTTSTTTTSATTSAQAAGPNYTIADYIRDNHIQETPVHHGDPGSPTIDLPVPDDWRLLPESSRAPYGGIVYTQPADPNDPPTIVAILSKLTGDIDPAKVLQFAPGELKNLPGFQGSGDGSAATLGGFSAWQLGGSYSKNGKLRTVAQKTVVIPSQGAVFVLQLNADALDDETMTLMDAANVIDEQTTITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF92</accession>
    <name>A0A7U8TF92_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TVP38/TMEM64 family membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403239.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="PTHR12677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="246" mass="25212" checksum="61B5CF73E4E15CBB" modified="2021-06-02" version="1">MSTHNDSAPTSRRRHIVRLVVFAGFLVGMFYLVAATDVIDVAAVRGAVSATGPAAPLTYVVVSAVLGALFVPGPILAASSGLLFGPLVGVFVTLGATVGTAVVASLVGRRAGRASARALLGGERADRTDALIERCGLWAVVGQRFVPGISDAFASYAFGTFGVPLWQMAVGAFIGSAPRAFAYTALGAAIGDRSPLLASCAIAVWCVTAIIGAFAARHGYRQWRAHARGDGADGGVEDPDREVGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFC8</accession>
    <name>A0A7U8TFC8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012906">
        <property type="entry name" value="PaaX-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013225">
        <property type="entry name" value="PaaX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07848">
        <property type="entry name" value="PaaX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08223">
        <property type="entry name" value="PaaX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PaaX" evidence="1">
        <location>
            <begin position="24"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="PaaX_C" evidence="2">
        <location>
            <begin position="190"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="240" mass="26713" checksum="86F61DAD7E2CD21F" modified="2021-06-02" version="1">MPAMTARSWYSACCSVLIPRGPPQSELIQLTADFGIKETTLRVALTRMVGAGDLVRSADGYRLSDRLLARQRRQDEAMRPRTRAWHGNWHMLIVTSIGTDARTRAALRTCMHHKRFGELREGVWMRPDNLDLDLESDVAARVRMLTARDEAPADLAGQLWDLSGWTEAGHRLLGDMAAATDMPGRFVVAAAMVRHLLTDPMLPAELLPADWPGAGLRAAYHDFATAMAKRRDATQLLEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFM1</accession>
    <name>A0A7U8TFM1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015837">
        <property type="entry name" value="UCP026622_CAAX_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026622">
        <property type="entry name" value="Proteas_026622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="209" mass="21614" checksum="87947A8B019AF030" modified="2021-06-02" version="1">MSRLRALSLAAGLVGWSLVSPRLPAPWRIPLQAGLGSVLVLVTRATMGLWPPRLWAGLRLGWAAGAAAATAIAATTPVPMVRLSMSARELPASVPVWLVWHIPGGTVWAEEAAFRGALATIGARAFGRSGGRVLQAGAFGLSHIADARATGEPLVLTVLATGIAGWMFGWLADRSGSLAAPLLTHLAINEAGAVAAVLVQRRSGISTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFP8</accession>
    <name>A0A7U8TFP8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="90" mass="10319" checksum="59F635F73DE461A6" modified="2021-06-02" version="1" fragment="single">PVVATADLSTAPTTMACWVRRSSRLLGLTSKRSDKLWRSRPVRLARRVLTTPRLQTRFQTANEEAAATMLRQLIRLPHNLHPWGESWQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFT7</accession>
    <name>A0A7U8TFT7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="49" mass="5392" checksum="707C7CBCD3491B4C" modified="2021-06-02" version="1">MRLAGNVGNIPIPIDCTLRGLTQYSRTNNAEVVQSVETHHRPANFDALT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG22</accession>
    <name>A0A7U8TG22_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine protease pepD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03146</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="368"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="464" mass="46467" checksum="AE93A4BB2BABDEE3" modified="2021-06-02" version="1">MAKLARVVGLVQEEQPSDMTNHPRYSPPPQQPGTPGYAQGQQQTYSQQFDWRYPPSPPPQPTQYRQPYEALGGTRPGLIPGVIPTMTPPPGMVRQRPRAGMLAIGAVTIAVVSAGIGGAAASLVGFNRAPAGPSGGPVAASAAPSIPAANMPPGSVEQVAAKVVPSVVMLETDLGRQSEEGSGIILSAEGLILTNNHVIAAAAKPPLGSPPPKTTVTFSDGRTAPFTVVGADPTSDIAVVRVQGVSGLTPISLGSSSDLRVGQPVLAIGSPLGLEGTVTTGIVSALNRPVSTTGEAGNQNTVLDAIQTDAAINPGNSGGALVNMNAQLVGVNSAIATLGADSADAQSGSIGLGFAIPVDQAKRIADELISTGKASHASLGVQVTNDKDTPGAKIVEVVAGGAAANAGVPKGVVVTKVDDRPINSADALVAAVRSKTPGATVALTFQDPSGGSRTVQVTLGKAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG29</accession>
    <name>A0A7U8TG29_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arginine deiminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginine deiminase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016990">
        <property type="term" value="F:arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018101">
        <property type="term" value="P:protein citrullination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003876">
        <property type="entry name" value="Arg_deiminase"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006356">
        <property type="entry name" value="Arg_deiminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01466">
        <property type="entry name" value="ARGDEIMINASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Amidino-cysteine intermediate" evidence="3">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006356-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="384" mass="41219" checksum="BD0D5A25F5D3FBF1" modified="2021-06-02" version="1">MGVELGSNSEVGALRVVILHRPGAELRRLTPRNTDQLLFDGLPWVSRAQDEHDEFAELLASRGAEVLLLSDLLIEALHHSGAARMQGIAAAVDAPRLGLPLAQELSAYLRSLDPGRLAHVLTAGMTFNELPSDTRTDVSLVLRMHHGGDFVIEPLPNLVFTRDSSIWIGPRVVIPSLALRARVREASLTDLIYAHHPRFTGVRRAYESRTAPVEGGDVLLLAPGVVAVGVGERTTPAGAEALARSLFDDDLAHRCARWSTPIAQQRAQIVDTLEAFTIQRTPDGVTIGDAAPFAEAAAKAMGIDKLRVIHTGMDPVVAEREQWDDGNNTLALAPGVVVAYERNVQTNARLQDAGIEVLTIAGSELGTGRGGPRCMSCPAARDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG64</accession>
    <name>A0A7U8TG64_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="85" mass="9486" checksum="5521310E4A308372" modified="2021-06-02" version="1">MIGPVGNWVLLFMQTLCESIRSPMEMGAPQGFSLIWCTRRFRIPPSCSMTGSSINCAYVELLRGYDRDRDIAALAAFIGVRPIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG94</accession>
    <name>A0A7U8TG94_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025339">
        <property type="entry name" value="DUF4245"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14030">
        <property type="entry name" value="DUF4245"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="233" mass="24563" checksum="C59154EF858CC2A5" modified="2021-06-02" version="1">MVGDCPRSRTVRWSWDTGHVTAEPQPTPRPAKPRLLQDGRDMFWSLAPLVVGCILLAGLVGMCSFQLGGTKRGPIPSYDAAQALRADAKTLGFPIRLPQLPGGWTPNSGGRGGIENGRADPATGQRRNAATSIVGFISPTGRYLSLTQSNADEDKLVGSIHPSMYPTGTVDVGGTRWVVYEGSDENGAVEPVWTTRLTGPGGATQLAITGAGSIDQFRTLASATQSQPPLPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG97</accession>
    <name>A0A7U8TG97_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mycothiol S-conjugate amidase</fullName>
            <ecNumber evidence="2">3.5.1.115</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mca</name>
        <name evidence="3" type="ORF">TBLG_03252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate</text>
            <dbReference type="Rhea" id="RHEA:36543"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58718"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="ChEBI" id="CHEBI:59633"/>
            <dbReference type="EC" id="3.5.1.115"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MshB deacetylase family. Mca subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.115" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405746.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG97"/>
    <dbReference type="GeneID" id="45425055"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010126">
        <property type="term" value="P:mycothiol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010127">
        <property type="term" value="P:mycothiol-dependent detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01482">
        <property type="entry name" value="Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017811">
        <property type="entry name" value="Mca"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF16">
        <property type="entry name" value="PTHR12993:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03446">
        <property type="entry name" value="mycothiol_Mca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="288" mass="32732" checksum="C19E3AAA882892DE" modified="2021-06-02" version="1">MSELRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGERGEILNPAMDLPDVHGRIAEIRRDEMTKAAEILGVEHTWLGFVDSGLPKGDLPPPLPDDCFARVPLEVSTEALVRVVREFRPHVMTTYDENGGYPHPDHIRCHQVSVAAYEAAGDFCRFPDAGEPWTVSKLYYVHGFLRERMQMLQDEFARHGQRGPFEQWLAYWDPDHDFLTSRVTTRVECSKYFSQRDDALRAHATQIDPNAEFFAAPLAWQERLWPTEEFELARSRIPARPPETELFAGIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGA5</accession>
    <name>A0A7U8TGA5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_03287</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405865.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGA5"/>
    <dbReference type="GeneID" id="45425088"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="2"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="124" mass="13477" checksum="08C64A0F6424C45C" modified="2021-06-02" version="1">MILVDTSVWIEHLRAADARLVELLGDDEAGCHPLVIEELALGSIKQRDVVLDLLANLYQFPVVTHDEVLRLVGRRRLWGRGLGAVDANLLGSVALVGGARLWTRDKRLKAACAESGVALAEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGE2</accession>
    <name>A0A7U8TGE2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">O-methyltransferase omt</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898744.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGE2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016874">
        <property type="entry name" value="TcmP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028177">
        <property type="entry name" value="Polyketide_synth_Omtfrase_TcmP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="282" mass="30887" checksum="41760C508774154A" modified="2021-06-02" version="1">MSAHKPAKQRVALTGVSETALLTLNARAAEARRRDAIIDDPMAVALVESIDFDFAKFGPTGQGFALRARAFDMAAQHYLDQHPAATVVALAEGLQTSFWRLDVAIPGGQFRWLTVDLPPIVDLRTRLLPSSPRVSVCAQSALDYSWMDSVDPAGGVFITAEGLLMYLQPEQALGLIAQCAQTFPGGQMLFDLPPRWFAGWSRLGLRTSLRYKVPRMPFSMSVAQAADLVNKVPGVVAVRDLRVPPGRGLWVNMALSTVYRLPVFDPLRPCLTLLEFSRPARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGF8</accession>
    <name>A0A7U8TGF8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406222.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGF8"/>
    <dbReference type="GeneID" id="45425166"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031494687" evidence="1">
        <location>
            <begin position="33"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="99" mass="9616" checksum="7E6A11535307DCA3" modified="2021-06-02" version="1">MSFVMAYPEMLAAAADTLQSIGATTVASNAAAAAPTTGVVPPAADEVSALTAAHFAAHAAMYQSVSARAAAIHDQFVATLASSASSYAATEVANAAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGI4</accession>
    <name>A0A7U8TGI4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">corA</name>
        <name evidence="7" type="ORF">TBLG_03416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406300.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGI4"/>
    <dbReference type="GeneID" id="45425209"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="366" mass="41502" checksum="F4FA350BE9805974" modified="2021-06-02" version="1">MFPGFDALPEVLRPVARPQPPNAHPVAQPPAQALVDCGVYVCGQRLPGKYTYAAALREVREIELTGQEAFVWIGLHEPDENQMQDVADVFGLHPLAVEDAVHAHQRPKLERYDETLFLVLKTVNYVPHESVVLAREIVETGEIMIFVGKDFVVTVRHGEHGGLSEVRKRMDADPEHLRLGPYAVMHAIADYVVDHYLEVTNLMETDIDSIEEVAFAPGRKLDIEPIYLLKREVVELRRCVNPLSTAFQRMQTESKDLISKEVRRYLRDVADHQTEAADQIASYDDMLNSLVQAALARVGMQQNMDMRKISAWAGIIAVPTMIAGIYGMNFHFMPELDSRWGYPTVIGGMVLICLFLYHVFRNRNWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGK7</accession>
    <name>A0A7U8TGK7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406566.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425243"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030723866" evidence="1">
        <location>
            <begin position="35"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="37"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="113" mass="11589" checksum="AE235E527DD5DE13" modified="2021-06-02" version="1">MLSPLSPRIIAAFTTAVGAAAIGLAVATAGTAGANTKDEAFIAQMESIGVTFSSPQVATQQAQLVCKKLASGETGTEIAEEVLSQTNLTTKQAAYFVVDATKAYCPQYASQLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGN9</accession>
    <name>A0A7U8TGN9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="133" mass="14753" checksum="81475CB80E2624C7" modified="2021-06-02" version="1">GLSPLPTAHPLSLQPKWVRASTRSYPRFTLAMGRSLRFGSRTRHYSHARMRVWVALFRLAFAAATPHGLTLRHVPDSQAHSSKGTPSPPSSGEEKEALTDCRHTVSGTLSLPSRGTFHHSLTVLIRYRSSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGQ9</accession>
    <name>A0A7U8TGQ9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031126548" evidence="2">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="106" mass="11400" checksum="556D24A3F43D81B1" modified="2021-06-02" version="1">MWRYPLSTRLALPNTPGVASFAMTSSPSTVSTTLLSILRDDLNIDLTRVTPDARLVDDVGLDSVAFAVGMVAIEERLGVALSEEELLTCDTVGELEAAIAAKYRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGR8</accession>
    <name>A0A7U8TGR8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406967.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425331"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030840810" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="123" mass="12850" checksum="338A49A108BE658F" modified="2021-06-02" version="1">MARTLALRASAGLVAGMAMAAITLAPGARAETGEQFPGDGVFLVGTDIAPGTYRTEGPSNPLILVFGRVSELSTCSWSTHSAPEVSNENIVDTNTSMGPMSVVIPPTVAAFQTHNCKLWMRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGW9</accession>
    <name>A0A7U8TGW9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407407.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425418"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD13046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="77" mass="8163" checksum="6DB2403163699EC6" modified="2021-06-02" version="1">MELALQITLIVTSVLVVLLVLLHRAKGGGLSTLFGGGVQSSLSGSTVVEKNLDRLTLFVTGIWLVSIIGVALLIKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGZ8</accession>
    <name>A0A7U8TGZ8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rplR</name>
        <name evidence="8" type="ORF">TBLG_02864</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403677.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGZ8"/>
    <dbReference type="GeneID" id="45424685"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 7" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="122" mass="13184" checksum="2BFFAF576C5ABDAE" modified="2021-06-02" version="1">MAQSVSATRRISRLRRHTRLRKKLSGTAERPRLVVHRSARHIHVQLVNDLNGTTVAAASSIEADVRGVPGDKKARSVRVGQLIAERAKAAGIDTVVFDRGGYTYGGRIAALADAARENGLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH66</accession>
    <name>A0A7U8TH66_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_02969</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898601.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH66"/>
    <dbReference type="GeneID" id="45424786"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="26"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="389" mass="41388" checksum="11F5EB06E561E0DB" modified="2021-06-02" version="1">MSRRRAIQPSPALRIGPIELASPVVLAPMAGVTNVAFRALCRQLEQSKVGTVSGLYVCEMVTARALIERHPVTMHMTTFSADESPRSLQLYTVDPDTTYAAARMIAGEGLADHIDMNFGCPVPKVTKRGGGAALPFKRRLFGQIVAAAVRATEGTDIPVTVKFRIGIDDAHHTHLDAGRIAEAEGAAAVALHARTAAQRYSGTADWEQIARLKQHVRTIPVLGNGDIYDAGDALAMMSTTGCDGVVIGRGCLGRPWLFAELSAAFTGSPAPTPPTLGEVADIIRRHGTLLAAHFGEDKGMRDIRKHIAWYLHGFPAGSALRRALAMVKTFDELDCLLDRLDGTVPFPDSATGARGRQGSPARVALPDGWLTDPDDCRVPEGADAMGSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THA6</accession>
    <name>A0A7U8THA6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02761</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403244.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THA6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="86" mass="9493" checksum="6B0E7DD0BB8BE563" modified="2021-06-02" version="1">MSEVASRELRNDTAGVLRRVRAGEDVTITVSGRPVAVLTPVRPRRRRWLSKTEFLSRLRGAQADPGLRNDLAVLAGDTTEDLGPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THF3</accession>
    <name>A0A7U8THF3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Coenzyme pqq synthesis protein E pqqE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_02836</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403490.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THF3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034391">
        <property type="entry name" value="Cmo-like_SPASM_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023913">
        <property type="entry name" value="MftC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01387">
        <property type="entry name" value="BtrN-like_SPASM_domain_contain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00316">
        <property type="entry name" value="C-terminal_tyrosine_decarboxyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03962">
        <property type="entry name" value="mycofact_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="16"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="340"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="391" mass="42448" checksum="CEE338AA1CE6A70A" modified="2021-06-02" version="1">MTSPVPRLIEQFERGLDAPICLTWELTYACNLACVHCLSSSGKRDPGELSTRQCKDIIDELERMQVFYVNIGGGEPTVRPDFWELVDYATAHHVGVKFSTNGVRITPEVATRLAATDYVDVQISLDGATAEVNDAIRGTGSFDMAVRALQNLAAAGFAGVKISVVITRRNVAQLDEFATLASRYGATLRITRLRPSGRGTDVWADLHPTADQQVQLYDWLVSKGERVLTGDSFFHLAPLGQSGALAGLNMCGAGRVVCLIDPVGDVYACPFAIHDHFLAGNVLSDGGFQNVWKNSSLFRELREPQSAGACGSCGHYDSCRGGCMAAKFFTGLPLDGPDPECVQGHSEPALARERHLPRPRADHSRGRRVSKPVPLTLSMRPPKRPCNESPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THH9</accession>
    <name>A0A7U8THH9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404098.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THH9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="335" mass="36048" checksum="2248C5CDE8606C30" modified="2021-06-02" version="1">MAVPAVSPQPILAPLTPAAIFLVATIGADGEATVHDALSKISGLVRAIGFRDPTKHLSVVVSIGSDAWDRLFAGPRPTELHPFVELTGPRHTAPATPGDLLFHIRAETMDVCFELAGRILKSMGDAVTVVDEVHGFRFFDNRDLLGFVDGTENPSGPIAIKATTIGDEDRNFAGSCYVHVQKYVHDMASWESLSVTEQERVIGRTKLDDIELDDNAKPANSHVALNVITDDDGTERKIVRHNMPFGEVGKGEYGTYFIGYSRTPTVTEQMLRNMFLGDPAGNTDRVLDFSTAVTGGLFFSPTIDFLDHPPPLPQAATPTLAAGSLSIGSLKGSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THJ0</accession>
    <name>A0A7U8THJ0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">3-hydroxyisobutyrate dehydrogenase</fullName>
            <shortName evidence="5">HIBADH</shortName>
            <ecNumber evidence="5">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_02896</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the HIBADH-related family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="5"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THJ0"/>
    <dbReference type="UniPathway" id="UPA00362"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011548">
        <property type="entry name" value="HIBADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01692">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="6">
        <location>
            <begin position="3"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="7">
        <location>
            <begin position="162"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU910714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="294" mass="29679" checksum="68DEF129A8BA3E68" modified="2021-06-02" version="1">MTTIAFLGLGNMGAPMSANLVGAGHVVRGFDPAPTAASGAAAHGVAVFRSAPEAVAEADVVITMLPTGEVVRRCYTDVLAAARPATLFIDSSTISVTDAREVHALAESHGMLQLDAPVSGGVKGAAAATLAFMVGGDESTLRRARPVLEPMAGKIIHCGAAGAGQAAKVCNNMVLAVQQIAIAEAFVLAEKLGLSAQSLFDVITGATGNCWAVHTNCPVPGPVPTSPANNDFKPGFSTALMNKDLGLAMDAVAATGATAPLGSHAADIYAKFAADHADLDFSAVIHTLRARADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THP4</accession>
    <name>A0A7U8THP4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="117"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="294" mass="33190" checksum="F5DF2B795B2B14F2" modified="2021-06-02" version="1">MRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWQGSPTWAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THR7</accession>
    <name>A0A7U8THR7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="6"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="448" mass="44465" checksum="5F2E3E11B9F9A79F" modified="2021-06-02" version="1">MMNFMVLPPEVNSARIYAGAGPAPMLAAAVAWDGLAAELGMAAASFSLLISGLTAGPGSAWQGPAAAAMAAAAAPYLSWLNAATARAEGAAAGAKAASAVYEAARAATAHPALVAANRNQLLSLVLSNLFGQNLPAIAATEASYEQLWAQDVAAMVGYHGGASTVASQLTPWQQLLSVLPPVVTAAPAGAVGVPAALAIPALGVENIGVGNFLGIGNIGNNNVGSGNTGDYNFGIGNIGNANLGNGNIGNANLGSGNAGFFNFGNGNDGNTNFGSGNAGFLNIGSGNEGSGNLGFGNAGDDNTGWGNSGDTNTGGFNSGDLNTGIGSPVTQGVANSGFGNTGTGHSGFFNSGNSGSGFQNLGNGSSGFGNASDTSSGFQNAGTALTRASSTWADSPRAWPIRAPSRLQVWRTRATTARECSIRVIISRVSSTGAPPKKSREQRVRENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THR8</accession>
    <name>A0A7U8THR8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="327" mass="37007" checksum="1DEBEBE5E6C357DA" modified="2021-06-02" version="1">MSAQRARSAVQASHRSIHPHIPGVPWWAAILIAVTATAIGYAIDAGSGHKALTLVFTGCYIAGCVGAVLAVRQSDLFTALVQPPLILFCAVPGAYWLFHGGTIGKFKDLLINCGYSLIERFPLMLGTAAGVLLIGLVRWYLGTALFDSIARKLSSLMTGDSDDDGGRRSAQRPARTRSRHARPPSEDNREPIAERRSRRRPRPQNDPHPRRNAHERPAPRSSRFDSYRSYQPSEPSGPAEPVNRYERRGARYQPYARYEPTYESQRRRARPSEPTNPTHHPISQVRYRGSATRDARRDNYREEQRFDRRDRSRAPRRPPAESWEYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THS7</accession>
    <name>A0A7U8THS7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03299</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405892.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THS7"/>
    <dbReference type="GeneID" id="45425099"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="201" mass="22197" checksum="F820B4D192863794" modified="2021-06-02" version="1">MSELTVLQAVRLKGRVITTDLAQTLGEDLADVAATVDRLTAAGLLVDATPLRISPSGRMRLDDLLAEERNRADSTVLAAAYRDFRSVNADFKRLVTDWQLKGEKPNTHDDAEYDAAVLSRLDGVHRRVGPIIGTVAMQLPRLSRYPVKLRAALDKVKAGDIAWLTRPLIDSYHTVWFELHEELIQAVGLTRDEAAKSGDAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THV1</accession>
    <name>A0A7U8THV1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404920.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THV1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="139" mass="14479" checksum="D6DAF1B4D11A1332" modified="2021-06-02" version="1">MRVNRPQCARVPYSAESLVRVEASWYGRTLRAIPEVLSQVGYQQADHGESLLTSHHCCLGAAEGARPGWVGSSAGALSGLLDSWAEASTAHAARIGDHSYGMHLAAVGFAEMEEHNAAALAAVYPTGGGSARCDGVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THW2</accession>
    <name>A0A7U8THW2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mycolyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="76" mass="8432" checksum="539A7C3DABE29135" modified="2021-06-02" version="1">MGGSFDRAARARRQLDNLVNVVAAGSTHRLMVPSRSMHRLIKVEFQGGGPHAWYLSDGILARDDYNGRDIHLPVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI12</accession>
    <name>A0A7U8TI12_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405595.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI12"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="148" mass="15980" checksum="7DB34E8917BA97CC" modified="2021-06-02" version="1">MGKGAAFDECACYTTRRAARQLGQAYDRALRPSGLTNTQFSTLAVISLSEGSAGIDLTMSELAARIGVERTTLTRNLEVMRRDGLVRVMAGADARCKRIELTAKGRAALQKAVPLWRGVQAEVTASVGDWPRVRRDIANLGQAAEACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI21</accession>
    <name>A0A7U8TI21_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="125" mass="13521" checksum="D6D48A95D4B6782F" modified="2021-06-02" version="1">MHWLRPDPTNQGGSGIKRVLGILSDRPVSSTMVGGGRVREELTSVDPPRSFGYTLTDIKGPLAPLVALVEGKWSFAPADTGTTVTWQWTIHPRSALAAPVLPVFARMWRGYARGVLEKLSALLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI57</accession>
    <name>A0A7U8TI57_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021941">
        <property type="entry name" value="DUF3556_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12077">
        <property type="entry name" value="DUF3556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="576" mass="63907" checksum="29234584D441A352" modified="2021-06-02" version="1">MGFLQPGLPDIDLAEWSQGSRSQKIRPMAQHWAEVGFGTPVLLHLFYVAKILLYVLVGWLIVLTTKGIDGFTDAAAWYAEPIVFEKVVLYTMLFEVIGLGCGFGPLNNRFFPPMGSILYWMRFGTIRLPPWPDRVPWTRGTKRKPVDVALYALLVMMLLSALFTDGAGPIPELGTTVGLLPAWQIVLILLLLGVLGLRDKVIFLAARGEVYATLTVTFLFGRLNGIDMIVAAKLVFLVIWIGAATSKLNRHFPFVISTMMSNNPLFRPRFIKRMFFKKFPGDLRPGLLSRIVAHVSTVIEMCVPVVLFVAHGGWPTVVAATIMVCFHLGILTAVPMGVPLEWNVFMIFGVLSLFVGHACLGLADVKNPVPLAILIAVVAGIVIAGNVFPRKISFLAAMRYYAGNWDTTLWCIKPSAEDKINRGIVAIASMPAAQLERFYGKDRAQIPMYLGYAFRAMNSHGRALFTLAHRAMAGHDEDDYVITDGERVCSTAVGWNFGDGHLHNEQLIAAMQQRCGFQPGEVRVVLLDAQPIHRQTQEYRLVDAATGEFERGYVRVADMVNRQPWDDDVPVHVLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIB4</accession>
    <name>A0A7U8TIB4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative fatty-acid-CoA ligase fadD21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05931">
        <property type="entry name" value="FAAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040097">
        <property type="entry name" value="FAAL/FAAC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="11"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="550" mass="59720" checksum="D47DA4A80CEBE4C9" modified="2021-06-02" version="1">MSDSSVLSLLRERAGLQPDDAAFTYIDYEQDWAGITETLTWSEVFRRTRIVAHEVRRHCTTGDRAVILAPQGLAYIAAFLGSMQAGAIAVPLSVPQIGSHDERVSAVLADASPSVILTTSAVAEAVAEHIHRPNTNNVGPIIEIDSLDLTGNSPSFRVKDLPSAAYLQYTSGSTRAPAGVMISHRNLQANFQQLMSNYFGDRNGVAPPDTTIVSWLPFYHDMGLVLGIIAPILGGYRSELTSPLAFLQRPARWLHSLANGSPSWSAAPNFAFELAVRKTTDADIEGLDLGNVLGITSGAERVHPNTLSRFCNRFAPYNFREDMIRPSYGLAEATLYVASRNSGDKPEVVYFEPDKLSTGSANRCEPKTGTPLLSYGMPTSPTVRIVDPDTCIECPAGTIGEIWVKGDNVAEGYWNKPDETRHTFGAMLVHPSAGTPDGSWLRTGDLGFLSEDEMFIVGRMKDMLIVYGRNHYPEDIESTVQEITGGRVAAISVPVDHTEKLVTVIELDSAGEAMDELDVIKNNVTAAISRSHGHRLATWSCPVRATASTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIF4</accession>
    <name>A0A7U8TIF4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="117" mass="11518" checksum="27AFD71E39EF89A4" modified="2021-06-02" version="1">MAPGEPAGPARTAVPAATAGGYTATVGSAATVGRPPRSGAMAATEATAATPGYGATGGRVEPERQERPAPTGKTRCPIRSRTRPMAPTALPDPMATGPTPARAATQSTPAWAVVQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR37</accession>
    <name>A0A7U8TR37_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF732 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007969">
        <property type="entry name" value="DUF732"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05305">
        <property type="entry name" value="DUF732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF732" evidence="2">
        <location>
            <begin position="58"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="136" mass="13945" checksum="4878839F9913CC15" modified="2021-06-02" version="1">MLTVGVGIGAAILLGWFTLAHRHPDQPGAAATPPPAGLTTRSAPTAAPPSTLQSPDLDSVFLGNLHDRGISFTNPDAAVYNGKMVCTNLGGGMTVQQVVEALQSSSPALGDRTTAYVAVSIRTYCPKYDAVLPPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR55</accession>
    <name>A0A7U8TR55_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Multidrugs transport membrane protein mmr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03685</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family. Mmr subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415995.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR55"/>
    <dbReference type="GeneID" id="45427058"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045324">
        <property type="entry name" value="Small_multidrug_res"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00893">
        <property type="entry name" value="Multi_Drug_Res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="107" mass="11083" checksum="3D372AC2FAE89834" modified="2021-06-02" version="1">MIYLYLLCAIFAEVVATSLLKSTEGFTRLWPTVGCLVGYGIAFALLALSISHGMQTDVAYALWSAIGTAAIVLVAVLFLGSPISVMKVVGVGLIVVGVVTLNLAGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR57</accession>
    <name>A0A7U8TR57_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, gntR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415989.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR57"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="265"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="490" mass="54008" checksum="C9E79EB4F75B9AD1" modified="2021-06-02" version="1">MSTEPDAVWTDKRASKIARRIEADIVRRGWPIGASLGSESALQQRFCVSRSVLREAVRLVEHHQVARMRRGPNGGLFICEPNAGPATRAVVIYLEYLGTTIGDLLGARLVLEPLAASLAAEHIDEPGIERLRAVLRAEERWRPGLPPPPEQFYRVLAEQSKNPVLQLFIDILMRLTKRYVQKSGTQSAGEAVEAAGQVHNEHSDIVAAVTAGDSAWAKTLSERHVEAVAGWLQQHQRGNDAAVRNGGRAREPRRAQQLILGAPRGKLAEVLAATIGDDIAASGWQVGSVFGTETALLERYQVSRAVLREAVRLLEYHAIAHMRRGPGGGLVVTTPQPQASIDTIALYLQYRKPSREDLRCVRDAIEIDNVAKVVKRRSEPEVASFLDTLGRPRLDNPTDDVRAAAVEEFRFHVGLARAAGNTMLDLFLLILVELFRRHLSSTEQALPTWSDVVAVGHAHVRILEAIGSGDDSLARCRTRRHLDAAASWWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR61</accession>
    <name>A0A7U8TR61_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415930.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="129" mass="14330" checksum="459444ABF4106646" modified="2021-06-02" version="1">MKPQDQGLHFPYRYDLRLAPMWLPFRWPGSQGVTVTEDGRFVARYGPFRVEAPLSSVRDAHITGPYRWWTAVGPRLSMVDDGLTFGTNAAAGVCIHFEPRIHRVIGLRDHSALTVTVADPEGLVAALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRA7</accession>
    <name>A0A7U8TRA7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase subunit I E nuoE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416434.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRA7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="252" mass="27198" checksum="07B62E1A282175A4" modified="2021-06-02" version="1">MTQPPGQPVFIRLGPPPDEPNQFVVEGAPRSYPPDVLARLEVDAKEIIGRYPDRRSALLPLLHLVQGEDSYLTPAGLRFCADQLGLTGAEVSAVASFYTMYRRRPTGEYLVGVCTNTLCAVMGGDAIFDRLKEHLGVGHDETTSDGVVTLQHIECNAACDYAPVVMVNWEFFDNQTPESARELVDSLRSDTPKAPTRGAPLCGFRQTSRILAGLPDQRPDEGQGGPGAPTLAGLQVARKNDMQAPPTPGADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRB6</accession>
    <name>A0A7U8TRB6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03809</name>
        <name evidence="3" type="ORF">TBLG_03968</name>
        <name evidence="4" type="ORF">TBLG_04020</name>
        <name evidence="5" type="ORF">TBLG_04078</name>
    </gene>
    <organism evidence="2 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="117"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="294" mass="33142" checksum="6F102E00FD9C4263" modified="2021-06-02" version="1">MRWGVESICTQLTELGVPIAPSTYYDHINREPSRRELRDGELKEHISRVHAANYGVYGARKVWLTLNREGIEVARCTVERLMTKLGLSGTTRGKARRTTIADPATARPADLVQRRFGPPAPNRLWVADLTYVSTWAGFAYVAFVTDAYARRILGWRVASTMATSMVLDAIEQAIWTRQQEGVLDLKDVIHHTDRGSQYTSIRFSERLAEAGIQPSVGAVGSSYDNALAETINGLYKTELIKPGKPWRSIEDVELATARWVDWFNHRRLYQYCGDVPPVELEAAYYAQRQRPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRC6</accession>
    <name>A0A7U8TRC6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Transcriptional regulator whib-like whiB7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD14926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="76" mass="8404" checksum="B8E8938D6366AD52" modified="2021-06-02" version="1">MSVLTVPRQTPRQRLPVLPCHVGDPDLWFADTPAGLEVAKTLCVSCPIRRQCLAAALQRAEPWAFGVVRYSTKARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRD0</accession>
    <name>A0A7U8TRD0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416628.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRD0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="40"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="286" mass="30913" checksum="3E51D0A6320CCB12" modified="2021-06-02" version="1">MPQRQAGDIGATYQDAPTKSINVGGTRFVYRRLGADAGVPVIFLHHLGAVLDNWDPRVVDGIAAKHPVVTFDNRGVGASEGQTPDTVTTMADDAIAFVRALGFDQVDLLGFSLGGFVAQVIAQQEPQLVRKIILAGTGPAGGVGIGKVTFGTIRESIKATLTFRDPKELRFFTRTDSGKSAARQFVKRLKERKDNRDKSITVRAFRSQLKAIHAWGTQKPSDLTSIGHPVLIANGDDDTMVPTSNSLDLADRLPDATLRIYPDAGHGGIFQHHAQFVDDALQFLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRD7</accession>
    <name>A0A7U8TRD7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, tetR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416861.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRD7"/>
    <dbReference type="GeneID" id="45427200"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045823">
        <property type="entry name" value="TetR_C_32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19344">
        <property type="entry name" value="TetR_C_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="228" mass="25166" checksum="E54EB0230F436702" modified="2021-06-02" version="1">MSDLAKTAQRRALRSSGSARPDEDVPAPNRRGNRLPRDERRGQLLVVASDVFVDRGYHAAGMDEIADRAGVSKPVLYQHFSSKLELYLAVLHRHVENLVSGVHQALSTTTDNRQRLHVAVQAFFDFIEHDSQGYRLIFENDFVTEPEVAAQVRVATESCIDAVFALISADSGLDPHRARMIAVGLVGMSVDCARYWLDADKPISKSDAVEGTVQFAWGGLSHVPLTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRD8</accession>
    <name>A0A7U8TRD8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved alanine and proline rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416793.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRD8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="153" mass="16286" checksum="8CAB8242ADB8CBBF" modified="2021-06-02" version="1">MIPQPLSQLGDLARRPGRRVLCSPKTAAPSISNATVASPAAPGLELSTGIALAFPRGPFVPAAAAWELQEATSGKFQLGLGTQVRKNVVHRYGMAFHRPGPRLRYLLAVKACFAVFQTGTPDHHGEFDNPDFITAQWSPARIDPPGPSPAGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRG0</accession>
    <name>A0A7U8TRG0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcriptional regulator WhiB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">whiB</name>
        <name evidence="13" type="ORF">TBLG_03850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="11">The Fe-S cluster can be nitrosylated by nitric oxide (NO).</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">Upon Fe-S cluster removal intramolecular disulfide bonds are formed.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the WhiB family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416884.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRG0"/>
    <dbReference type="GeneID" id="45427212"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035731">
        <property type="term" value="F:dinitrosyl-iron complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01479">
        <property type="entry name" value="WhiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034768">
        <property type="entry name" value="4FE4S_WBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003482">
        <property type="entry name" value="Whib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38839">
        <property type="entry name" value="PTHR38839"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02467">
        <property type="entry name" value="Whib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51674">
        <property type="entry name" value="4FE4S_WBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6 11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S Wbl-type" evidence="12">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD14952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="84" mass="9319" checksum="E06C6D18F7C31ED2" modified="2021-06-02" version="1">MDWRHKAVCRDEDPELFFPVGNSGPALAQIADAKLVCNRCPVTTECLSWALNTGQDSGVWGGMSEDERRALKRRNARTKARTGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRG6</accession>
    <name>A0A7U8TRG6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416925.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="169" mass="17797" checksum="E1AD4DD0B9BE9A8F" modified="2021-06-02" version="1">MTQVYIPATLAMLQRLVADGALWPVNGTAFAVTPTLRESYAEGDDEELAEVALREAALASLRLLAADIGATADALPPRRAVLAAEVDDATYRPDLDDAVVRLAGPITIDQVVAAYVDNAGAEPAVMAAIAVIDAADLGDEDAELVVGDAQDHDLAWYANQELPFLLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRH1</accession>
    <name>A0A7U8TRH1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Abasic site processing protein</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the SOS response-associated peptidase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416907.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRH1"/>
    <dbReference type="GeneID" id="45427220"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:cellular response to DNA damage stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1680.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003738">
        <property type="entry name" value="SRAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036590">
        <property type="entry name" value="SRAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13604">
        <property type="entry name" value="PTHR13604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02586">
        <property type="entry name" value="SRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143081">
        <property type="entry name" value="SSF143081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="252" mass="27640" checksum="60048E53445CE67D" modified="2021-06-02" version="1">MCGRFAVTTDPAQLAEKITAIDEATGCGGGKTSYNVAPTDTIATVVSRHSEPDDEPTRRVRLMRWGLIPSWIKAGPGGAPDAKGPPLINARADKVATSPAFRSAVRSKRCLVPMDGWYEWRVDPDATPGRPNAKTPFFLHRHDGALLFTAGLWSVWKSYRSAPPLLSCTVITTDAVGELAEIHDRMPLLLAEEDWDDWLNPDAPPDPELLARPPDVRDIALRQVSTLVNNVRNNGPELLEPARSQPEQIQLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRH5</accession>
    <name>A0A7U8TRH5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03897</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417076.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRH5"/>
    <dbReference type="GeneID" id="45427253"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010428">
        <property type="entry name" value="Zincin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038555">
        <property type="entry name" value="Zincin_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06262">
        <property type="entry name" value="Zincin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="139" mass="15649" checksum="8E672E766CB888FD" modified="2021-06-02" version="1">MRGPLLPPTVPGWRSRAERFDMAVLEAYEPIERRWQERVSQLDIAVDEIPRIAAKDPESVQWPPEVIADGPIALARLIPAGVDVRGNATRARIVLFRKPIERRAKDTEELGELLHEILVAQVAIYLDVDPSVIDPTIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRJ1</accession>
    <name>A0A7U8TRJ1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cationic amino acid transport membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03891</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable amino-acid or metabolite transport protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417049.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRJ1"/>
    <dbReference type="GeneID" id="45427247"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="495" mass="52520" checksum="A95457F288213D33" modified="2021-06-02" version="1">MAGRRRMKSVEQSIADTDEPTTRLRKDLTWWDLVVFGVSVVIGAGIFTVTASTAGDITGPAIWISFLIAAATCALAALCYAEFASTLPVAGSAYTFSYATFGEFLAWVIGWNLVLELAMGAAVVAKGWSSYLGTVFGFGNGTGHLGSLQLDWGALVIVTLVATLIALGTKLSSRFSAVVTAIKVSVVVLVVVVGAFYIRAANYSPFIPEPEVQHHGGGLDQSVFSLLTGAQGSHYGWYGVLAGASIVFFAFIGFDIVATMAEETKRPQRDVPRGILASLGVVTLLYVAVSVVLSGMVPYTQLRTVPGRGPANLATAFQANGVYWASGIISVGALAGLTTVVMVLMLGQCRVLFAMARDGLVPRQLAKTGSRGTPVRVTVLVAVLVATTASVFPITKLEEMVNVGTLFAFILVSAGVVVLRRTRPDLQRGFTAPWVPLLPIAAVCACLWLMLNLTALTWIRFGIWLVAGTAIYVGYGRRHSAQGLRQARESATRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRL2</accession>
    <name>A0A7U8TRL2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417257.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427312"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030606310" evidence="2">
        <location>
            <begin position="31"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="103" mass="10768" checksum="2E02E76F1E4885D1" modified="2021-06-02" version="1">MYRFACRTLMLAACILATGVAGLGVGAQSAAQTAPVPDYYWCPGQPFDPAWGPNWDPYTCHDDFHRDSDGPDHSRDYPGPILEGPVLDDPGAAPPPPAAGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRQ9</accession>
    <name>A0A7U8TRQ9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="38"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="405" mass="36748" checksum="F9DBE568AE84D1D3" modified="2021-06-02" version="1">MNLPQTPRPLAHIALASGCCDLAGCVLAAWGWVVMSFVVAVPEALAAAASDVANIGSALSAANAAAAAGTTGLLAAGADEVSAALASLFSGHAVSYQQVAAQATALHDQFVQALTGAGGSYALTEAANVQQNLLNAINAPTQALLGRPLIGDGAVGTASSPDGQDGGLLFGNGGAGYNSAATPGMAGGNGGNAGLIGNGGTGGSGGAGAAGGAGGSGGWLYGNGGNGGIGGNAIVAGGAGGNGGAGGAAGLWGSGGSGGQGGNGLTGNDGVNPAPVTNPALNGAAGDSNIEPQTSVLIGTQGGDGTPGGAGVNGGNGGAGGDANGNPANTSIANAGAGGNGAAGGDGGANGGAGGAGGQAASAGSSVGCDGCYGGARRLRARTGTPAVRAVSACRWSRRVAGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRR1</accession>
    <name>A0A7U8TRR1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase echA18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_04028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="214" mass="22719" checksum="237EA06C032A6743" modified="2021-06-02" version="1" fragment="single">MRRRAMTKMDEASNPCGGDIEAEMCQLMREQPPAEGVVDRVALQRHRNVALITLSHPQAQNALNLASWRRLKRLLDDLAGESGLRAVVLRGAGDKAFAAGADIKEFPNTRMSAADAAEYNESLAVCLRALTTMPIPVIAAVRGLAVGGGCELATACDVCIATDDARFGIPLGKLGVTTGFTEADTVARLIGPAALKYLLFSGELIGIEEAARWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRR6</accession>
    <name>A0A7U8TRR6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein lpqD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417932.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRR6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030522743" evidence="1">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="236" mass="25056" checksum="7BE5F0495BF3F532" modified="2021-06-02" version="1">MAKRTPVRKACTVLAVLAATLLLGACGGPTQPRSITLTFIRNAQSQANADGIIDTDMPGSGLSADGKAEAQQVAHQVSRRDVDSIYSSPMAADQQTAGPLAGELGKQVEILPGLQAINAGWFNGKPESMANSTYMLAPADWLAGDVHNTIPGSISGTEFNSQFSAAVRKIYDSGHNTPVVFSQGVAIMIWTLMNARNSRDSLLTTHPLPNIGRVVITGNPVTGWRLVEWDGIRNFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRT4</accession>
    <name>A0A7U8TRT4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD_binding_9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417969.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427399"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038732">
        <property type="entry name" value="HpyO_NAD-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13454">
        <property type="entry name" value="NAD_binding_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_9" evidence="1">
        <location>
            <begin position="19"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="533" mass="57880" checksum="FD575D42C8082B84" modified="2021-06-02" version="1">MLAFPYLMTMITPPTFDVAFIGSGAACSMTLLEMADALLSSPSASPKLRIAVVERDEQFWCGIPYGQRSSIGSLAIQKLDDFADEPEKAAYRIWLEQNKQRWLAFFQAEGGAAAARWICDNRDALDGNQWGELYLPRFLFGVFLSEQMIAAIAALGERDLAEIVTIRAEAMSAHSADGHYRIGLRPSGNGPTAIAAGKVVVAIGSPPTKAILASDSEPAFTYINDFYSPGGESNVARLRDSLDRVESWEKRNVLVVGSNATSLEALYLMRHDARIRARVRSITVISRSGVLPYMICNQPPEFDFPRLRTLLCTEAIAAADLMSAIRDDLATAEERSLNLADLYDAVAALFGQALHKMDLVQQEEFFCVHGMNFTKLVRRAGRDCRQASEELAADGTLSLLAGEVLRVDACASGQPFATMTYRAAGAEHTHPVPFAAVVNCGGFEELDTCSSPFLVSAMQNGLCRPNRTNRGLLVNDDFEASPGFCVIGPLVGGNFTPKIRFWHVESAPRVRSLAKSLAASLLASLQPVALAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRW8</accession>
    <name>A0A7U8TRW8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Esat-6 like protein esxU</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04099</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036689">
        <property type="entry name" value="ESAT-6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010310">
        <property type="entry name" value="T7SS_ESAT-6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06013">
        <property type="entry name" value="WXG100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140453">
        <property type="entry name" value="SSF140453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="125" mass="13494" checksum="1A270ADDB1FA3F34" modified="2021-06-02" version="1">MVEPGRIGGNQTRLAAVLLDVSTPNTLNADFDLMRSVAGITDARNEEIRAMLQAFIGRMSGVPPSVWGGLAAARFQDVVDRWNAESTRLYHVLHAIADTIRHNEAALREAGQIHARHIAAAGGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRZ1</accession>
    <name>A0A7U8TRZ1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418922.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427467"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021315">
        <property type="entry name" value="Gap/Sap"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11139">
        <property type="entry name" value="SfLAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="229" mass="23793" checksum="454D403694149B18" modified="2021-06-02" version="1">MRGLLPVAGHWVSVLTGLVPLALVIALSPLSVIPAVLVVHSPQPRPSSLAFLGGWLLGLAVVTAVFVAASGALGGLSTTSPAWASWLRVVLGSALIVFGVLRWLTRHRHTEMPGWMRAFASFTPARAGLVGAVLVVVRPEVLIICAAAGLAIGSGGHGAAGSWIYTAFFAMLAASTVAIPILAYVAAGDRLDDSLERLKDWMEKNHAGMVAAILVVIGLLLLYNGVHAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSQ3</accession>
    <name>A0A7U8TSQ3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03684</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415994.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="141" mass="15134" checksum="AD4FEC72DF45B35A" modified="2021-06-02" version="1">MVKDLDRRLAGCLPAVLSLFRLVYGLLFAGYGSMILFGWPVTSAQPVEFGSWPGWYAGVIELVAGLLIATGLFTRAVAFVASGEMAVAYFWMHQPYALWPIGGPPDGNGGTPAILFCFGFFLLVFTGGGIYSIDARRTVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTS2</accession>
    <name>A0A7U8TTS2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="78" mass="9038" checksum="35D3D6C9222DD43A" modified="2021-06-02" version="1">MKEYAVTSPKDLPYGEDRIMVRWNKIRWRCREDYCKLGPFTEAITQVPARVRSTLRLRRQMAKAIGDAARSVGRGRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTV2</accession>
    <name>A0A7U8TTV2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="159" mass="17241" checksum="97FF348F0C4A2C04" modified="2021-06-02" version="1" fragment="single">MVGRAVPSPNRRYRRVWPPRTKGQHFVQPICPAPAEAHQAHGCADPVAATHLRGLRDARAMRSGVQVGADLQPARWLVEFGVAPRDELDRADFQLQCDSAGASRRRRGVRSPRPARHRPSSRSPGTHTGGLVSRPVRGGTALLGRCDVDPLDPSATSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTX5</accession>
    <name>A0A7U8TTX5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Anti-sigma factor rsbW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03926</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417160.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTX5"/>
    <dbReference type="GeneID" id="45427283"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="145" mass="15551" checksum="4DB92A33771723BA" modified="2021-06-02" version="1">MADSDLPTKGRQRGVRAVELNVAARLENLALLRTLVGAIGTFEDLDFDAVADLRLAVDEVCTRLIRSALPDATLRLVVDPRKDEVVVEASAACDTHDVVAPGSFSWHVLTALADDVQTFHDGRQPDVAGSVFGITLTARRAASSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y270</accession>
    <name>A0A7U8Y270_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methylmalonate-semialdehyde dehydrogenase (Acylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403847.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y270"/>
    <dbReference type="GeneID" id="45424717"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="PTHR43866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="17"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="510" mass="54454" checksum="1C4F4BB84B74A096" modified="2021-06-02" version="1">MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAAWNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLLKGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDPSVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAATGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLRARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDLTFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHEYGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAAIQFYTKVKTVTSRWPSGIKDGAEFVIPTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2G3</accession>
    <name>A0A7U8Y2G3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03198</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="207"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="284"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="509" mass="54607" checksum="F6F11A1093A7E176" modified="2021-06-02" version="1">MIPDRNTRSRKAPCWRPRSLRQQLLLGVLAVVTVVLVAVGVVSVLSLSGYVTAMNDAELVECLHALNHSYTRYRDSAQTSTPTGNLPMSQAVLEFTGQTPGNLIAVLHDGVVIGSAVFSEDGARPAPPDVIRAIEAQVWDGGPPRVESLGSLGAYQVDSSAAGADRLFVGVSLSLANQIIARKKVTTVALVGAALVVTAALTVWVVGYALRPLRRVAATAAEVATMPLTDDDHQISVRVRPGDTDPDNEVGIVGHTLNRLLDNVDGALAHRVDSDLRMRQFITDASHELRTPLAAIQGYAELTRQDSSDLPPTTEYALARIESEARRMTLLVDELLLLSRLSEGEDLETEDLDLTDLVINAVNDAAVAAPTHRWVKNLPDEPVWVNGDHARLHQLVSNLLTNAWVHTQPGVTVTIGITCHRTGPNAPCVELSVTDDGPDIDPEILPHLFDRFVRASKSRSNGSGHGLGLAIVSSIVKAHRGSVTAESGNGQTVFRVRLPMIEQQIATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2K0</accession>
    <name>A0A7U8Y2K0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein mce2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01782">
        <property type="entry name" value="MCEVIRFACTOR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="137"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="481" mass="50777" checksum="C8753865CC00D059" modified="2021-06-02" version="1">MRTLTEFNRGRVGMMGAVVTVLVVGVAQSFTSVPMLFATPTYYAQFADTGGINTGDKVEIAGVNVGLVRSLAIRGNRVLIGFSLPGKTIGMQSRAAIRTDTILGRKNLEIEPRGSEPLKPNGFLPLAQTTTPYQIYDAFVDVTKAATGWDIDAVKRSLNVLSETFDQTAPHLSAALEGVKAFSDTVGRRGEQIEQLLANANRIARVLGDRSEQVNGLLVNAKTLLAAFKQRSQALRILLTNVSEASAQVSGLITDNPNLNHVLAQLRTVSEELVKRKNELADVAVLLGRYTAALTEAVGSGPFFKAMVVNLLPYQILQPWVDAAFKKRGIDPENFWRSAGLPEFRWPDPNGTRFPNGAPPAAPPVREGTPKHPGPAVPPGTPCSYTPAAGALPRPDNPLPCAGATVGPFGGPDFPAPLDVQPSPPNPDGPPPTPGILSAGRPGEPAPAVPGIPMPLPPNAPPGARTQPLEPFPDGTGGSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2L2</accession>
    <name>A0A7U8Y2L2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_02753</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403218.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2L2"/>
    <dbReference type="GeneID" id="45424579"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006226">
        <property type="entry name" value="Mtu_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00028">
        <property type="entry name" value="Mtu_PIN_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="133" mass="13970" checksum="98B9993106CF372D" modified="2021-06-02" version="1">MTVLLDANVLIALVVAEHVHHDAAADWLMASDTGFATCPMTQGSLVRFLVRSGQSAAAARDVVSAVQCTSRHEFWPDALSFAGVEVAGVVGHRQVTDAYLAQLARSHDGQLATLDSGLAHLHGDVAVLIPTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2M2</accession>
    <name>A0A7U8Y2M2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898788.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2M2"/>
    <dbReference type="GeneID" id="45425215"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="276" mass="29215" checksum="95E2EA43E916E6F6" modified="2021-06-02" version="1">MEGFAGKVAVVTGAGSGIGQALAIELARSGAKVAISDVDTDGLADTEHRLKAISTPVKTDRLDVTEREAFLAYADAVNEHFGTVNQIYNNAGIAFTGDIEVSQFKDIERVMDVDFWGVVNGTKAFLPHLIASGDGHVINISSVFGLFSAPGQAAYNSAKFAVRGFTEALRQEMALAGHPVKVTTVHPGGVKTAIARNATAAEGLDQAELAETFDKRVAHLSPQRAAQIILTGVAKNKARVLVGVDAKVLDLVVRLTGSGYQRIFPIITGRLIPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2R5</accession>
    <name>A0A7U8Y2R5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="218" mass="24930" checksum="99A58FF5B1BE059C" modified="2021-06-02" version="1">MSRHWPLFDLRITTPRLQLQLPTEELCDQLIDTILEGVHDPDRMPFSVPWTRASREDLPFNTLSHLWQQLAGFKRDDWSLPLAVLVDGRAVGVQALSSKDFPITRQVDSGSWLGLRYQGHGYGTEMRAAVLYFAFAELEAQVATSRSFVDNPASIAVSRRNGYRDNGLDHVAREGAMAEALLLRLTRDDWQRHRTVEVRVDGFDRCRPLFGPLEPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2T6</accession>
    <name>A0A7U8Y2T6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold shock protein B cspB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404570.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2T6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="135" mass="15021" checksum="494AD2474E8BD996" modified="2021-06-02" version="1">MPTGKVKWYDPDKGFGFLSQEGGEDVYVRSSALPTGVEALKAGQRVEFGIASGRRGPQALSLRLIEPPPSLSRPRREPAAEHKHSPDELHGMVEDMITLLESTVQPELRKGRYPDRKTARRVAEVVRAVAREFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2T8</accession>
    <name>A0A7U8Y2T8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmF</name>
        <name evidence="6" type="ORF">TBLG_03141</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405053.1">
        <property type="nucleotide sequence ID" value="NZ_KK338675.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2T8"/>
    <dbReference type="GeneID" id="45424948"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="57" mass="6507" checksum="2EF45101DDBF5921" modified="2021-06-02" version="1">MAVPKRRKSRSNTRSRRSQWKAAKTELVGVTVAGHAHKVPRRLLKAARLGLIDFDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Z7</accession>
    <name>A0A7U8Y2Z7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NTE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405642.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Z7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046470">
        <property type="term" value="P:phosphatidylcholine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001423">
        <property type="entry name" value="LysoPLipase_patatin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01237">
        <property type="entry name" value="UPF0028"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="19"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="251"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="3">
        <location>
            <begin position="166"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="360" mass="37523" checksum="F08C30CE6096D0F6" modified="2021-06-02" version="1">MPAPAALRVRGSSSPRVALALGSGGARGYAHIGVIQALRERGYDIVGIAGSSMGAVVGGVHAAGRLDEFAHWAKSLTQRTILRLLDPSISAAGILRAEKILDAVRDIVGPVAIEQLPIPYTAVATDLLAGKSVWFQRGPLDAAIRASIAIPGVIAPHEVDGRLLADGGILDPLPMAPIAGVNADLTIAVSLNGSEAGPARDAEPNVTAEWLNRMVRSTSALFDVSAARSLLDRPTARAVLSRFGAAAAESDSWSQAPEIEQRPAGPPADREEAADTPGLPKMGSFEVMNRTIDIAQSALARHTLAGYPADLLIEVPRSTCRSLEFHRAVEVIAVGRALATQALEAFEIDDDESAAATIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y310</accession>
    <name>A0A7U8Y310_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406290.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425204"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="175" mass="18605" checksum="94ED6FAC38BBBD9B" modified="2021-06-02" version="1">MTSPFQPRQVPGSTPAAAGAGRRGVPALPTPPKGWPVGSYPTYAEAQRAVDYLSEQQFPVQQVTIVGVDLMQVERVTGRLTWPKVLGGGVLSGAWLGLFIGLVLGFFSPNPWSALVTGLVAGVFFGLITSAVPYAMARGTRDFSSTMQLVAGRYDVLCDPQNAEKARDLLARLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y360</accession>
    <name>A0A7U8Y360_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenylyl cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406372.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y360"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032026">
        <property type="entry name" value="Ad_Cy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16701">
        <property type="entry name" value="Ad_Cy_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="397" mass="42232" checksum="F6C212A181DB5AD3" modified="2021-06-02" version="1">MTDHVREADDANIDDLLGDLGGTARAERAKLVEWLLEQGITPDEIRATNPPLLLATRHLVGDDGTYVSAREISENYGVDLELLQRVQRAVGLARVDDPDAVVHMRADGEAAARAQRFVELGLNPDQVVLVVRVLAEGLSHAAEAMRYTALEAIMRPGATELDIAKGSQALVSQIVPLLGPMIQDMLFMQLRHMMETEAVNAGERAAGKPLPGARQVTVAFADLVGFTQLGEVVSAEELGHLAGRLAGLARDLTAPPVWFIKTIGDAVMLVCPDPAPLLDTVLKLVEVVDTDNNFPRLRAGVASGMAVSRAGDWFGSPVNVASRVTGVARPGAVLVADSVREALGDAPEADGFQWSFAGPRRLRGIRGDVRLFRVRRGATRTGSGGAAQDDDLAGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y361</accession>
    <name>A0A7U8Y361_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="53"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="274" mass="30081" checksum="B902B77BBD16D8D7" modified="2021-06-02" version="1">MTVYTPTSERQAPATTHRQMWALGDYAAIAEELLAPLGPILVSTSGTRRGDRVLDVAAGSGNVSIPAAMAGAHVTASDLTLELLRRAQARAAAAGLELGWREANAEALPFSAGEFDAVLSTIGVMFAPRHQRTADELARVCRRGGKISTLNWTPEGFYGKLLSTIRPYRPTLPAGAPHEVWWGSEDYVSGLFRDHVSDIRTRRGSLTVDRFGCPDECRDYFKNFYGPAINAYRSIADSPECVATLDAEITELCREYLCDGVMQWEYLIFTARKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y381</accession>
    <name>A0A7U8Y381_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406908.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y381"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="PTHR36512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="344" mass="33953" checksum="296A055FECF8E650" modified="2021-06-02" version="1">MNSITDVGGIRVGHYQRLDPDASLGAGWACGVTVVLPPPGTVGAVDCRGGAPGTRETDLLDPANSVRFVDALLLAGGSAYGLAAADGVMRWLEEHRRGVAMDSGVVPIVPGAVIFDLPVGGWNCRPTADFGYSACAAAGVDVAVGTVGVGVGARAGALKGGVGTASATLQSGVTVGVLAVVNAAGNVVDPATGLPWMADLVGEFALRAPPAEQIAALAQLSSPLGAFNTPFNTTIGVIACDAALSPAACRRIAIAAHDGLARTIRPAHTPLDGDTVFALATGAVAVPPEAGVPAALSPETQLVTAVGAAAADCLARAVLAGVLNAQPVAGIPTYRDMFPGAFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y402</accession>
    <name>A0A7U8Y402_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="7">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="7">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fabH</name>
        <name evidence="10" type="ORF">TBLG_02662</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402861.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y402"/>
    <dbReference type="GeneID" id="45424497"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="9">
        <location>
            <begin position="116"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="8">
        <location>
            <begin position="242"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="7">
        <location>
            <begin position="259"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="335" mass="34873" checksum="6573BE1FAE5BCFB6" modified="2021-06-02" version="1">MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y409</accession>
    <name>A0A7U8Y409_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_02677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898500.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y409"/>
    <dbReference type="GeneID" id="45424513"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09873">
        <property type="entry name" value="PIN_Pae0151-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044153">
        <property type="entry name" value="PIN_Pae0151-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="137" mass="14700" checksum="16A91120CA498A7E" modified="2021-06-02" version="1">MRASPTSPPEQVVVDASAMVDLLARTSDRCSAVRARLARTAMHAPAHFDAEVLSALGRMQRAGALTVAYVDAALEELRQVPVTRHGLSSLLAGAWSRRDTLRLTDALYVELAETAGLVLLTTDERLARAWPSAHAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y423</accession>
    <name>A0A7U8Y423_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein Mce4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y423"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="39"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="115"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="343" mass="36747" checksum="2B8EF5129D60B8D1" modified="2021-06-02" version="1">MKTTGTTIKLGIVWLVLSVFTVMIIVVFGQVRFHHTTGYSAVFTHVSGLRAGQFVRAAGVEVGKVAKVTLIDGDKQVLVDFTVDRSLSLDQATTASIRYLNLIGDRYLELGRGHSGQRLAPGATIPLEHTHPALDLDALLGGFRPLFQTLDPDKVNSIASSIITVFQGQGATINDILDQTASLTATLADRDHAIGEVVNNLNTVLATTVKHQTEFDRTVDKLEVLITGLKNRADPLAAAAAHISSAAGTLADLLGADRPLLHSSFGHLEGIQQPLIDELAELDHVLGKLPDAYRIIGRAGGIYGDFFNFYLCDISLKVNGLQPGGPVRTVKLFGQPTGRCTPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4E8</accession>
    <name>A0A7U8Y4E8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404873.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4E8"/>
    <dbReference type="GeneID" id="45424922"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019921">
        <property type="entry name" value="Lucif-like_OxRdtase_Rv2161c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="SSF51679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03619">
        <property type="entry name" value="F420_Rv2161c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bac_luciferase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="282" mass="30913" checksum="81DDBAA488937C2B" modified="2021-06-02" version="1">MHYGLVLFTSDRGITPAAAARLAESHGFRTFYVPEHTHIPVKRQAAHPTTGDASLPDDRYMRTLDPWVSLGAASAVTSRIRLATAVALPVEHDPITLAKSIATLDHLSHGRVSVGVGFGWNTDELVDHGVPPGRRRTMLREYLEAMRALWTQEEACYDGEFVKFGPSWAWPKPVQPHIPVLVGAAGTEKNFKWIARSADGWITTPRDVDIDEPVKLLQDIWAAAGRDGLPQIVALDVKPVPDKLARWAELGVTEVLFGMPDRSADDAAAYVERLAAKLACCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4G3</accession>
    <name>A0A7U8Y4G3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011964">
        <property type="entry name" value="YVTN_b-propeller_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="SSF50974"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02276">
        <property type="entry name" value="beta_rpt_yvtn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="197" mass="20663" checksum="FCA624241746056D" modified="2021-06-02" version="1">RDPSRRYRRYGWRRLCRWARRRRHHHHPHQLHDPHGVAVNPGGNIYVTNQGSNTVSVIDPVTNTVTGSITDGNGPSGVAVSPVTGLVFVTNFDSNTVSVIDPNTNTVTGSIPVGTGAYGVAVNPGGNIYVTNQFSNTVSVIDPATNTVTGSPIPVGLDPTGVAVNPVTGVVYVTNSLDDTVSVITGEPARSVCSAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4H3</accession>
    <name>A0A7U8Y4H3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4H3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="129" mass="13949" checksum="F29D124E8B2FD5B9" modified="2021-06-02" version="1">MHVGDELPLAELTVRAVGGCHAVIHPEIPVIENISYLVGDSKHRARLMHPGDALFVPGEQVDVLATPAAAPWMKISEAVDYLRAVAPARAVPIHQAIVAPDARGIYYGRLTEMTTTDFQVLPEESAVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4I8</accession>
    <name>A0A7U8Y4I8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02964</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4I8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="1">
        <location>
            <begin position="124"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="255" mass="27581" checksum="9D3EB21443229D24" modified="2021-06-02" version="1">MLELLLLTSELYPDPVLPALSLLPHTVRTAPAEASSLLEAGNADAVLVDARNDLSSGRGLCRLLSSTGRSIPVLAVVSEGGLVAVSADWGLDEILLPSTGPAEIDARLRLVVGRRGDLADQESLGKVSLGELVIDEGTYTARLRGRPLDLTYKEFELLKYLAQHAGRVFTRAQLLHEVWGYDFFGGTRTVDVHVRRLRAKLGPEHEALIGTVRNVGYKAVRPARGRPPAADPDDEDADPGRDGMQEPLVDPLRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4L3</accession>
    <name>A0A7U8Y4L3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405917.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425107"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="78" mass="8195" checksum="68A7C574C2198167" modified="2021-06-02" version="1">MAAYQKFGQEHAAAIRGGAVLHPTATATTVRVTGARGGDVVTGDGPYEAADLDEQGPFPMETVYLWEDGPNGTTRMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4M8</accession>
    <name>A0A7U8Y4M8_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAP_DH_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404767.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4M8"/>
    <dbReference type="GeneID" id="45424892"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAP_DH_C" evidence="1">
        <location>
            <begin position="145"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="358" mass="37751" checksum="8EA50A4066EC6C3C" modified="2021-06-02" version="1">MAIPVVQLGTGNVGVHSLRALIADPEFELTGVWVSSDAKAGKDAAELAGLADSTGVRASTDLNAVLATGPRCAVYNAMADNRLPEALEDYRRILAAGINIVGSGPVFLQYPWQVIPDEIIKPLQDAARAGNSSLYVNGIDPGFANDLLPMALAGTCESIEQIRCMEIVDYATYDSAVVMFDVMGFGKPMDQIPMLLQPGVLSLAWGSVVRQLAAGLGISLDGVEEMYVREPAPEAFNIASGHIPKGSAAALRFEVLGLVDGVPAVVLEHVTRLRADLCPEWPQPAQPGGSYRIEISGEPCYAMDICLSSRHGDHNHAGLVATAMRIVNAIPAVVAAEPGIRTTLDLPLITGEGRYAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4N8</accession>
    <name>A0A7U8Y4N8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fatty-acid-CoA ligase fadD6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03382</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406240.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4N8"/>
    <dbReference type="GeneID" id="45425176"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030310">
        <property type="entry name" value="FadD17/FadD6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="PTHR43107:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="53"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="474"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="597" mass="64337" checksum="A0BEB5EB19A05CB7" modified="2021-06-02" version="1">MSDYYGGAHTTVRLIDLATRMPRVLADTPVIVRGAMTGLLARPNSKASIGTVFQDRAARYGDRVFLKFGDQQLTYRDANATANRYAAVLAARGVGPGDVVGIMLRNSPSTVLAMLATVKCGAIAGMLNYHQRGEVLAHSLGLLDAKVLIAESDLVSAVAECGASRGRVAGDVLTVEDVERFATTAPATNPASASAVQAKDTAFYIFTSGTTGFPKASVMTHHRWLRALAVFGGMGLRLKGSDTLYSCLPLYHNNALTVAVSSVINSGATLALGKSFSASRFWDEVIANRATAFVYIGEICRYLLNQPAKPTDRAHQVRVICGNGLRPEIWDEFTTRFGVARVCEFYAASEGNSAFINIFNVPRTAGVSPMPLAFVEYDLDTGDPLRDASGRVRRVPDGEPGLLLSRVNRLQPFDGYTDPVASEKKLVRNAFRDGDCWFNTGDVMSPQGMGHAAFVDRLGDTFRWKGENVATTQVEAALASDQTVEECTVYGVQIPRTGGRAGMAAITLRAGAEFDGQALARTVYGHLPGYALPLFVRVVGSLAHTTTFKSRKVELRNQAYGADIEDPLYVLAGPDEGYVPYYAEYPEEVSLGRRPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4X3</accession>
    <name>A0A7U8Y4X3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">OpcA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004555">
        <property type="entry name" value="G6PDH_assembly_OpcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38658">
        <property type="entry name" value="PTHR38658"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10128">
        <property type="entry name" value="OpcA_G6PD_assem"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00534">
        <property type="entry name" value="OpcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD13053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="303" mass="32632" checksum="02CC8BC5132A9F2C" modified="2021-06-02" version="1">MIVDLPDTTTTAVNKKLDELREKIGAVAMGRVLTLSIAPDSEAMLEESIEAANDASHEHPSRIIVTMRGDPYADRPRLDAQLRVGADAGAGEFVVLRLSGPLAGHADSVVIPFLLPDIPVVAWWPDIAPAVPAQDALGKLAIRRITDATNAIDPLSAIKSRLAGYGAGDTDLAWSRITYWRALLTSAVDQPPHEPIESALVSGLKTEPALDVLAGWLASRIEGPVRRAVGELKVELVRNSETIVLSRPQEGITATLTRTGKPDALVPLARRVTGECLAEDLRRLDPDEIYCAALEGIKKVQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4X6</accession>
    <name>A0A7U8Y4X6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AAA_12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_12" evidence="1">
        <location>
            <begin position="84"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="291" mass="30951" checksum="9CA8035000CD665B" modified="2021-06-02" version="1">MIGGTAWDFANGNRVPKASLDLLVIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPEPVDTSALSWLVDGQHTLPDERGYFLDRSYRMHPAVCAAVSALSYEGRLCSHTERTAVRRLDGYPPGVHTRGVHHKGNSIESPEEAEAILAELRQLLGSPWTDEHGTRPLAASDVLVLAPYNAQVALVRRRLASAGLGGADGVRVGTVDKFQGGQAPVVFISMTASSADDVPRGISFLLNRNRLNVAVSRAQYAAVIVRSELLTQYLPATPDGLVDLGAFLGLTSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y535</accession>
    <name>A0A7U8Y535_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="10">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03624</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="10"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407390.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y535"/>
    <dbReference type="GeneID" id="45425414"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="6">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD13040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="339" mass="35956" checksum="362D0D59E90A4588" modified="2021-06-02" version="1">MTVRVGINGFGRIGRNFYRALLAQQEQGTADVEVVAANDITDNSTLAHLLKFDSILGRLPCDVGLEGDDTIVVGRAKIKALAVREGPAALPWGDLGVDVVVESTGLFTNAAKAKGHLDAGAKKVIISAPATDEDITIVLGVNDDKYDGSQNIISNASCTTNCLAPLAKVLDDEFGIVKGLMTTIHAYTQDQNLQDGPHKDLRRARAAALNIVPTSTGAAKAIGLVMPQLKGKLDGYALRVPIPTGSVTDLTVDLSTRASVDEINAAFKAAAEGRLKGILKYYDAPIVSSDIVTDPHSSIFDSGLTKVIDDQAKVVSWYDNEWGYSNRLVDLVTLVGKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7I6</accession>
    <name>A0A7U8Y7I6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">TBLG_03883</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416988.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7I6"/>
    <dbReference type="GeneID" id="45427239"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="235"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="302"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="526"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD14985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="567" mass="61619" checksum="B4C73DF5D69D064E" modified="2021-06-02" version="1">MIFGSRRRIRGRRGRSGPMTRGLSALSRAVAVAWRRSLQLRVVALTLGLSLAVILALGFVLTSQVTNRVLDIKVRAAIDQIERARTTVSGIVNGEETRSLDSSLQLARNTLTSKTDPASGAGLAGAFDAVLMVPGDGPRAASTAGPVDQVPNALRGFVKAGQAAYQYATVQTEGFSGPALIIGTPTLSRVANLELYLIFPLASEQATITLVRGTMATGGLVLLVLLAGIALLVSRQVVVPVRSASRIAERFAEGHLSERMPVRGEDDMARLAVSFNDMAESLSRQIAQLEEFGNLQRRFTSDVSHELRTPLTTVRMAADLIYDHSADLDPTLRRSTELMVSELDRFETLLNDLLEISRHDAGVAELSVEAVDLRTTVNNALGNVGHLAEEAGIELLVDLPAEQVIAEVDARRVERILRNLIANAIDHAEHKPVRIRMAADEDTVAVTVRDYGVGLRPGEEKLVFSRFWRSDPSRVRRSGGTGLGLAISVEDARLHQGRLEAWGEPGEGACFRLTLPLVRGHKVTTSPLPMKPIPQPVLQPVAQPNPQPMPPEYKERQRPREHAEWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7L3</accession>
    <name>A0A7U8Y7L3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="176" mass="20270" checksum="D57B7BFD00967D5B" modified="2021-06-02" version="1">MHLMIPAEYISNVIYEGPRADSLYAADQRLRQLADSVRTTAESLNTTLDELHENWKGSSSEWMADAALRYLDWLSKHSRQILRTARVIESLVMAYEETLLRVVPPATIANNREEVRRLIASNVAGVNTPAIADLEAQYEQYRAENIQAMDRYLSWTRFALSKLPRWREPPQIHRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7P3</accession>
    <name>A0A7U8Y7P3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="544" mass="53838" checksum="B7D66868A90D30B7" modified="2021-06-02" version="1">MGGGNIGGNNVGLGNVGFGNVGLANSGLTPGLMGLGNIGFGNAGSYNFGLANMGVGNIGFANTGSGNFGIGLTGDNLTGFGGFNTGSGNVGLFNSGTGNVGFFNSGTGNWGVFNSGSYNTGIGNSGIVSTGLFNAGGFNTGVVNAGSYNTGSFNAGQANTGGFNPGSVNTGWLNTGDTNTGVANSGDVNTGAFISGNYSNGAFWRGDYQGLLGFSYTSTIIPEFTVANIHASGGAGPIIVPSIQFPAIPLDLSATGHIGGFTIPPVSISPITVRIDPVFDLGPITVQDITIPALGLDPATGVTVGPIFSSGSIIDPFSLTLLGFINVNVPAIQTAPSEILPFTVLLSSLGVTHLTPEITIPGFHIPVDPIHVELPLSVTIGPFVSPEITIPQLPLGLALSGATPAFAFPLEITIDRIPVVLDVNALLGPINAGLVIPPVPGFGNTTAVPSSGFFNIGGGGGLSGFHNLGAGMSGVLNAISDPLLGSASGFANFGTQLSGILNRGADISGVYNTGALGLITSALVSGFGNVGQQLAGLIYTGTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7U9</accession>
    <name>A0A7U8Y7U9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03708</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 11"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416079.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7U9"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="UniPathway" id="UPA00606"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014292">
        <property type="entry name" value="Acyl_transf_WS/DGAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WES_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02946">
        <property type="entry name" value="acyl_WS_DGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="WES_acyltransf" evidence="12">
        <location>
            <begin position="5"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="WS_DGAT_C" evidence="13">
        <location>
            <begin position="313"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD14810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="474" mass="50887" checksum="36832D972BE3851A" modified="2021-06-02" version="1">MTRINPIDLSFLLLERANRPNHMAAYTIFEKPKGQKSSFGPRLFDAYRHSQAAKPFNHKLKWLGTDVAAWETVEPDMGYHIRHLALPAPGSMQQFHETVSFLNTGLLDRGHPMWECYIIDGIERGRIAILLKVHHALIDGEGGLRAMRNFLSDSPDDTTLAGPWMSAQGADRPRRTPATVSRRAQLQGQLQGMIKGLTKLPSGLFGVSADAADLGAQALSLKARKASLPFTARRTLFNNTAKSAARAYGNVELPLADVKALAKATGTSVNDVVMTVIDDALHHYLAEHQASTDRPLVAFMPMSLREKSGEGGGNRVSAELVPMGAPKASPVERLKEINAATTRAKDKGRGMQTTSRQAYALLLLGSLTVADALPLLGKLPSANVVISNMKGPTEQLYLAGAPLVAFSGLPIVPPGAGLNVTFASINTALCIAIGAAPEAVHEPSRLAELMQRAFTELQTEAGTTSPTTSKSRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y827</accession>
    <name>A0A7U8Y827_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416827.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y827"/>
    <dbReference type="GeneID" id="45427189"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011915">
        <property type="entry name" value="GlrX_actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02200">
        <property type="entry name" value="GlrX_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="84" mass="8963" checksum="6E7DD7F00D4CAF3F" modified="2021-06-02" version="1">MITAALTIYTTSWCGYCLRLKTALTANRIAYDEVDIEHNRAAAEFVGSVNGGNRTVPTVKFADGSTLTNPSADEVKAKLVKIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y850</accession>
    <name>A0A7U8Y850_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="49" mass="5493" checksum="0A1127706D04D355" modified="2021-06-02" version="1">MTFALATIGYPDMAVLQPMPTINLPTDQFTAFGQKWLLGSKFSKKDDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAA0</accession>
    <name>A0A7U8YAA0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900042.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAA0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030760349" description="UmuC domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="2">
        <location>
            <begin position="31"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="527" mass="56667" checksum="33004BB73793E2F5" modified="2021-06-02" version="1">MMASARVLAIWCMDWPAVAAAAAAGLSATAPVAVTLANRVIACSATARAAGVRRGLRRREAAARCPQLFIATADADRDARLFEGVIAAVDDLVPRAELLRPGLLVLPVRGPARFFGSEQMAAERLIDAVAAAGAECQVGIADRLSTAVFAARAGRIVEPGGDARFLSLLSIRQLATEPSLSGPGRDDLTDLLWRMGIRTIGQFAALSRTDVASRFGADAVAAHRFARGEPERAPCGREPPPDLAAELACDPPIDRVDAAAFAGRSLAAELHRALMAAGVGCTRLAIHAVTANGEERSRVWRCAEPLTEDATADRVRWQLDGWLNNRNARDRPTAAVTLLRLQAVETVSASEGLQLPLWGGLGEQDRLRARRALVRVQGLLGPEAVRVPVLSGGHGPAERITLTVLGLVAPEPVPQADPGQPWPGRLPDPSPAVLFDDPVDLLDAQGNPIRVTSRGMFSADPARLRVRGRDDRLRWWAGPWPDDERWWDPDRASGRTARAQVLLDGDPGTALLLCYRQRRWYLEGSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAA7</accession>
    <name>A0A7U8YAA7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclopropane-fatty-acyl-phospholipid synthase 1 cmaA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAA7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="33"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="68"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="94"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR003085-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="287" mass="32434" checksum="38F7AEE3A67B7943" modified="2021-06-02" version="1">MPDELKPHFANVQAHYDLSDDFFRLFLDPTQTYSCAYFERDDMTLQEAQIAKIDLALGKLGLQPGMTLLDVGCGWGATMMRAVEKYDVNVVGLTLSKNQANHVQQLVANSESLRSKRVLLAGWEQFDEPVDRIVSIGAFEHFGHERYDAFFSLAHRLLPADGVMLLHTITGLHPKEIHERGLPMSFTFARFLKFIVTEIFPGGRLPSIPMVQECASANGFTVTRVQSLQPHYAKTLDLWSAALQANKGQAIALQSEEVYERYMKYLTGCAEMFRIGYIDVNQFTCQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAE5</accession>
    <name>A0A7U8YAE5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418948.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAE5"/>
    <dbReference type="GeneID" id="45427474"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="107" mass="11928" checksum="CCE62597646F6D94" modified="2021-06-02" version="1">MREFQRAAVRLHILHHAADNEVHGAWLTQELSRHGYRVSPGTLYPTLHRLEADGLLVSEQRVVDGRARRVYRATPAGRAALTEDRRALEELAREVLGGQSHTAGNGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF48</accession>
    <name>A0A7U8TF48_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="2"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="224" mass="24980" checksum="C5C810CE0043FED2" modified="2021-06-02" version="1" fragment="single">MKVAISGAGVAGAALAHWLQRTGHTPTVIERAPKFRTGGYMIDFWGVGYQVAKRMGITDQIAAAGYHMEHVRSVGPTGKVKADLGVDVFRRMVGDDFTSLPRGDLAAAIYTTIEDQVETIFDDSIATIDEHRDGVRLTFERTAPRDFDLVIGADGLHSNVRRLVFGPERDFEHYLGCKVAACVVDGYRAPRRAQLCPLQHRRRQLARFALRGDRTMFLFVFRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF97</accession>
    <name>A0A7U8TF97_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpmG</name>
        <name evidence="5" type="ORF">TBLG_02771</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898538.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF97"/>
    <dbReference type="GeneID" id="66747094"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="55" mass="6496" checksum="62BCB421312500B6" modified="2021-06-02" version="1">MASSTDVRPKITLACEVCKHRNYITKKNRRNDPDRLELKKFCPNCGKHQAHRETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFC3</accession>
    <name>A0A7U8TFC3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403039.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFC3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="71" mass="7605" checksum="A4B0A063FCD9CC6E" modified="2021-06-02" version="1">MDKTTVYLPDELKAAVKRAARQRGVSEAQVIRESIRAAVGGAKPPPRGGLYAGSEPIARRVDELLAGFGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFD7</accession>
    <name>A0A7U8TFD7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferredoxin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901000.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFD7"/>
    <dbReference type="GeneID" id="45424650"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="18"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Reductase_C" evidence="2">
        <location>
            <begin position="330"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="406" mass="43018" checksum="6EB261AB726B6E71" modified="2021-06-02" version="1">MNAHVTSREGVNEFDDGIVIVGGGLAAARTAEQLRRAGYSGRLTIVSDEVHLPYDRPPLSKEVLRSEVDDVALKPREFYDEKDIALRLGSAAVSLDTGEQTVTLADGTVLGYDELVIATGLVPRRIPSLPDLDGIRVLRSFDESMALRKHASAARHAVVVGAGFIGCEVAASLRGLGVDVVLVEPQPAPLASVLGEQIGQLVTRLHRDEGVDVRTGVTVAEVRGKGHVDAVVLTDGTELPADLVVVGIGSTPATEWLEGSGVEVDNGVICDKAGRTSAPNVWALGDVASWRDPMGHQARVEHWSNVADQARVVVPAMLGTDVPTGVVVPYFWSDQYDVKIQCLGEPHATDVVHLVEDDGRKFLAYYERDGVLVGVVGGGMAGKVMKVRGKIAAGAPIAEVLDQTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFD9</accession>
    <name>A0A7U8TFD9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain type dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403468.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFD9"/>
    <dbReference type="GeneID" id="45424649"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023985">
        <property type="entry name" value="SDR_subfam_1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03971">
        <property type="entry name" value="SDR_subfam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="275" mass="29028" checksum="43E9EB57986474C3" modified="2021-06-02" version="1">MSARGGSLHGRVAFVTGAARAQGRSHAVRLAREGADIVALDICAPVSGSVTYPPATSEDLGETVRAVEAEGRKVLAREVDIRDDAELRRLVADGVEQFGRLDIVVANAGVLGWGRLWELTDEQWETVIGVNLTGTWRTLRATVPAMIDAGNGGSIVVVSSSAGLKATPGNGHYAASKHALVALTNTLAIELGEFGIRVNSIHPYSVDTPMIEPEAMIQTFAKHPGYVHSFPPMPLQPKGFMTPDEISDVVVWLAGDGSGALSGNQIPVDKGALKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFE2</accession>
    <name>A0A7U8TFE2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="75" mass="8862" checksum="6B737EE77237207C" modified="2021-06-02" version="1">MELWAWTWERHGFRAFAETAAPQLIWREYRPGWTRYGDGSVAQVKSIFDAPRGYLNAACRRRVVHWASGLLRRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFH6</accession>
    <name>A0A7U8TFH6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="90" mass="9250" checksum="6543B6DA6F5F8ECC" modified="2021-06-02" version="1">MEKSRCHAVAHGGGCAGSAKSHKSGGRCGQGRGAGDSHGTRGAGRRYRAASAPHPLAVGAHLRDELAKRSADPRLTDELNDLAGHTLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFI6</accession>
    <name>A0A7U8TFI6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase fadE9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_02897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403845.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFI6"/>
    <dbReference type="GeneID" id="45424716"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="120"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="233"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="390" mass="41451" checksum="575EC02696ADED2F" modified="2021-06-02" version="1">MFVLNDDERVIVETAAAFAGKRLAPHALEWDAAKHFPVDVLREAAELGMAAIYCRDDVGGSGLRRLDGVRIFEQLAIADPVTAAFLSIHNMCAWMIDSFGTDEQRKDWIPRLATMGVIASYCLTEPGAGSDAGALSTRAVRHGSGKGGDYVLDGVKQFISGAAASDVYVVMARTGAEGPRGVSAFIVEKGTPGLSFGAPEAKMGWHAQPTAQVVLDGVRVPAEAMLGGADGEGAGFGIAMSGLNGGRLNIAACSLGGAQAAFDKAGAYVRDRQAFGGSLLDEPTVRFTLADMATGLQTSRMLLWRAASALDDDDADKVELCAMAKRYVTDTCFEVADQALQLHGGYGYLREYGLEKIVRDLRVHRILEGTNEIMRLVIGRAEAARFRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFN2</accession>
    <name>A0A7U8TFN2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403887.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFN2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="181" mass="20614" checksum="227DA92FAA50A4DC" modified="2021-06-02" version="1">MAGYPRDELEDVVHRWLQANRTAERRGDWTLLADFYTDDATYGWNVGPNEDVMCVGIDEIRDIALGQEMDGLQGWRYPYQRVVIDEKQGEVVGFWKQVATDANGAEQEVYGIGGSWFRYAGGGKWNWQRDFFDFGHVSALYLELIKAGKLSPGMQKRIERAVSGNKVPGYYPLGKTPVPLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFP6</accession>
    <name>A0A7U8TFP6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MPAB_Lcp_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898602.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPAB_Lcp_cat" evidence="2">
        <location>
            <begin position="59"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="351" mass="40281" checksum="E7E9CD4C805FCBA9" modified="2021-06-02" version="1">MTQDTSATCPLTSTVQDSSPVAGQLGRPIGFRGLAGGCPVSPLGYESPPLPLGPDSLTWRYFGDWRGMLQGPWAGSMQNMHPQLGAAVEDHSTFFRERWPRLLRSLYPIGGVVFDGDRAPVTGVQVRDYHITIKGVDGAGRRYHALNPDVFYWAHATFFVGTLHVAERFCGGLTEAQRRQLFDEHVQWYRMYGMSMRPVPATWEEFQDYWDHMCRNVLENNFAARAVLDLTELPKPPFAQRVPDWLWAAPRKLLARFFVWLTVGLYDPPVRELMGYRWLRRDEWLHRRFGDIVRLVFALVPFRFRKHPRARAGWDRATGRIPADAPLVQTPARNLPPPDERDNPTHYCPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFR7</accession>
    <name>A0A7U8TFR7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Helicase_C_3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase_C_3" evidence="3">
        <location>
            <begin position="479"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="740" mass="77598" checksum="884110DC35225D21" modified="2021-06-02" version="1">MTEHTPDIPLGSWLAALPDERLTQLLELRPDLAQPPPGSIAALAARAQARQSVKAATDELDFLRLAVFDALLVLQADTAPVPIVRLLAVIGDRAAQADVLGALADLKQRALAWGETAVRVATDAGTALPWHPGQVTLEGSSRSGDQLADLIAGLDPAQRDVLDKLLQGSPVGRTRDAAPGAPSDRPVPRLLAMGLLRRIDAETVILPRHVGQVLRGEQPGPMELTAPDPVVSTTTPDDADAAAAGAVIDLLREVDVLLENLGATPVAELRSGGLGVREFKRLAKATGIDEPRLGLILEIAAAAGLIASGMPDPEPPHSDGPFWAPTVAADRFATMSPAERWHLLASAWLDLPGRPALIGTRGPDAKPYGALSDSLFSTAAPLDRRLLLGMLAELPAGAGVDASRASATLIWRRPRWARRLQPAPIADLLTEGHALGLVGRGAISTPARALLDEALEPATAPAAAVGVMARALPKPIDHFLVQADLTVVVPGPLQRELADDLTTVATVESAGTAMVYRVSEQSIRHALDVGKSRDWLQEFFANRSKTPVPQGLTYLIDDVARRHGQLRIGMAASFVRCEDPTLLAQVVAAPEADGLALRALAPTVAVSPAPISEVLVTLRGAGFAPAAEDSTGAVVDVRTRGARVPTPQRRRPYRPPPRPNSEALKAVVAVLREVTAAPFANVRVDPAVTMSLLQRAAKDQATLVISYLDAAGVATSAGGRTDHATGRPAGGVRLVIRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFU7</accession>
    <name>A0A7U8TFU7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lactamase_B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="2"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="189" mass="20990" checksum="59FB43802634A037" modified="2021-06-02" version="1">RAPFLVPLGVGAHLRSWGVPQDRIVELDWNQSAQVDELTVVCVPARHFSGRFLSRNTTLWASWAFVGPNHRAYFGGDTGYTKSFTQIGADHGPFDLTLLPIGAYNTAWPDIHMNPEEAVRAHLDVTDSGSGMLVPVHWGTFRLAPHPWGEPVERLLAAAEPEHVTVAVPLPGQRVDPTGPMRLHPWWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG39</accession>
    <name>A0A7U8TG39_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="75" mass="7841" checksum="EB7F7326F3CCE9DE" modified="2021-06-02" version="1">MPAVGPQASALAEVGGAHQSQAQKPYHDATEPLGENLRYRPAHGDSCINGHRDNPSARESSQFTAGSTAKAVTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG57</accession>
    <name>A0A7U8TG57_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="197" mass="21430" checksum="3A33B463108AFF9A" modified="2021-06-02" version="1">MKVQARVGWNRRQLSAVGGRGQQLFANAPGHIPSTSHRRGTGDINRKIDESLAGAARPQANANYGATSDPPLTHQPKPGSPTQVGPRSPSPPGLRGLVKQLPEVHQSSLHLDTVASLPSSRPSPHHTPLALRSRSGHFSPDEIRNRRSRKRSQSHMPPRTPPRGRCLRAPESARLGRRSAAHRHSIARNARAIPFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG62</accession>
    <name>A0A7U8TG62_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Potassium-transporting ATPase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405313.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425001"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="48" mass="5451" checksum="629C389293252F77" modified="2021-06-02" version="1">MADLVLVLTVMAFAGLCLLYVRGCERIIRRDEIGETTVELTRAPAEWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG66</accession>
    <name>A0A7U8TG66_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="102" mass="11169" checksum="1C877EEC72D83E7A" modified="2021-06-02" version="1">MCSTATGTIPGNVGTTSRRSSRRLLGSQHLPTKRSYPRSALSTYLVFDALIAHGDRHDRNWAVHVPPLETKYVEALCPSFDHAASLGFTLTDQTPAQHLHDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG84</accession>
    <name>A0A7U8TG84_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="270" mass="21231" checksum="A620C82F1857DEC5" modified="2021-06-02" version="1">MGAGGAGAAGGFGGISAATPSAGSEGAMGGAGGVGGNARLLGTGGAGGVGGGGGVGGLGGLGTAINNVDAGSGAGGGGGGAGGTGGTAGLLYGVGGAGGGGGAGGDGGRGGVATPGGQGGDAGDGGAGGAGGNGGGGASGAGGWLLGTGGAGGAGGNGGNGGKAGFSPGPTNFGLNGAGGGGGVGGNGATGPWLFGDGGAGGGGGAGGIGGDGGPTPGSTGAGAAGGHGGDAQLIGNGGHGGAGGTGVPNGSGGAGGLSGLLFGEPGANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG90</accession>
    <name>A0A7U8TG90_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7 8">Pantothenate kinase</fullName>
            <ecNumber evidence="4 7 8">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coaA</name>
        <name evidence="10" type="ORF">TBLG_03266</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7 8">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the prokaryotic pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="4 7 8"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405790.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG90"/>
    <dbReference type="GeneID" id="45425066"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02025">
        <property type="entry name" value="PanK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00215">
        <property type="entry name" value="Pantothen_kinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004566">
        <property type="entry name" value="PanK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285:SF139">
        <property type="entry name" value="PTHR10285:SF139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000545">
        <property type="entry name" value="Pantothenate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00554">
        <property type="entry name" value="panK_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7 8" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRK" evidence="9">
        <location>
            <begin position="92"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="312" mass="35657" checksum="F075B543AE75788D" modified="2021-06-02" version="1">MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVEEVYLPLARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVAVGKSTTARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNRRALMRFVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILILEGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAFADPESHFHHYAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDADHSINRLRLRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGB8</accession>
    <name>A0A7U8TGB8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyruvate, phosphate dikinase ppdK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGB8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="78"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PPDK_N" evidence="2">
        <location>
            <begin position="269"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="389"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="490" mass="52073" checksum="CD6A26B8B4A5167C" modified="2021-06-02" version="1">MTRITRANGCPDGTLENAVVALDGGANYPREILGNKGHGIDMMRRHHLPVPPAFCITTEVGVRYLAAPESTIAAIWDDVLDRMSWLETETSCTFGRGPNPLLVSVRSGATQSMPGMMDTILDVGMTDAVERVLARPGAADFAHDTRRRFTSMYRRIVGSAGPITDDPYAQLRASIEAVFASWNSPRAVAYRDHHGLDDQGGTAVVVQAMVFGNLTANSGAGVLSSRNPITGANEPFGEWLPGGQGDDVVSGLVAVAPITALRDQQPAVYDQLMAAARSLERMAGDVQEIEFTVEDSQLWLLQTRGAERSAQAAVRLALQLHHEGLIDDTETLRRVTPTHIETLLRPSLQPETRLAAPLLAKGLPACPGVVSGTAYTEVDEALDAADRGEPVILVRDHTRPEDVMGMLAAQGIVTEVGGAASHAAVVSRELGRVAVVGCGPGVAAALAGKEITVDGYEGEVRQGVLALSAWSESDTPELRELADIAQRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGD4</accession>
    <name>A0A7U8TGD4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405932.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGD4"/>
    <dbReference type="GeneID" id="45425111"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="338" mass="36346" checksum="6C809C814B7C9415" modified="2021-06-02" version="1">MTSYDTDLLVVGGGPGGLATALHARARGLSVIVAEPRENPIDKACGEGLMPGGLAELTSLGVDPVGLPFHGIAYVGEHRRVQARFRTGPGRGVRRTTLHAALAARAKEQDTEWIRSRVATIQQDAHGVTAAGVRAKWLVAADGLHSAVRRAVGIKATAGTPRRYGVRWHYRLPVWSDFVEVHWSRWGEAYVTPVEPDLVGVAILSRQRPELAWFPSLAHHLQDASRGHARGCGPLRQVVSRRVAGRVLLVGDAAGYEDALTGEGISLAVKQAAAAVSAIVDDTPASYEAAWHRITRDYRLVTRGLVLASTPRAARRAIVPLCALLPTAFRYGVNILAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGD9</accession>
    <name>A0A7U8TGD9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
            <shortName evidence="3">GlcNAc-Ins deacetylase</shortName>
            <ecNumber evidence="3">3.5.1.103</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mshB</name>
        <name evidence="4" type="ORF">TBLG_03347</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deacetylation of 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate</text>
            <dbReference type="Rhea" id="RHEA:26180"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:52442"/>
            <dbReference type="ChEBI" id="CHEBI:58886"/>
            <dbReference type="EC" id="3.5.1.103"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MshB deacetylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.103" evidence="3"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406154.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGD9"/>
    <dbReference type="GeneID" id="45425142"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035595">
        <property type="term" value="F:N-acetylglucosaminylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010125">
        <property type="term" value="P:mycothiol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01696">
        <property type="entry name" value="MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017810">
        <property type="entry name" value="Mycothiol_biosynthesis_MshB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="PTHR12993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="SSF102588"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03445">
        <property type="entry name" value="mycothiol_MshB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="303" mass="31742" checksum="09824FF2C02FB3C7" modified="2021-06-02" version="1">MSETPRLLFVHAHPDDESLSNGATIAHYTSRGAQVHVVTCTLGEEGEVIGDRWAQLTADHADQLGGYRIGELTAALRALGVSAPIYLGGAGRWRDSGMAGTDQRSQRRFVDADPRQTVGALVAIIRELRPHVVVTYDPNGGYGHPDHVHTHTVTTAAVAAAGVGSGTADHPGDPWTVPKFYWTVLGLSALISGARALVPDDLRPEWVLPRADEIAFGYSDDGIDAVVEADEQARAAKVAALAAHATQVVVGPTGRAAALSNNLALPILADEHYVLAGGSAGARDERGWETDLLAGLGFTASGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGF3</accession>
    <name>A0A7U8TGF3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proline dehydrogenase</fullName>
            <ecNumber evidence="3">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="7">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900287.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGF3"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008219">
        <property type="entry name" value="PRODH_bac_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PTHR13914"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000196">
        <property type="entry name" value="Pro_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="52"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="200"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000196-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="329" mass="36237" checksum="49E72626A32FBE15" modified="2021-06-02" version="1">MAGWFAHTLRPAMLAAGRSDRLGRIVERSPLTRGVVRRFVPGDTLDDVVDIVTALRDSGRYLSIDYLGENVTDADDAAAAVRAYLGLLDVLGRRGDIACDGVRPLEVSLKLSALGQALDRDGQKIALDNARAICERAERVGAWVTVDAEDHTTTDSTLSISGDLRVDFPWLGTVVQAYLRRTLADCAELAAVGARVRLCKGAYDEPASVAYRDAAQVTDSYLRCLRVLTAGRGYPMVATHDPVIIAAVPGITRESGRSQGDFEYQMLYGVRDDEQRRLTGAGNHVRVYVPFGTRWYGYFLRRLAERPANLAFFLRALTDRRRARGCAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGM4</accession>
    <name>A0A7U8TGM4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403001.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGM4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="10"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="243"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="443" mass="46655" checksum="CC64EF0CE8C598A8" modified="2021-06-02" version="1">MKLFDDRGDAGRQLAQRLAQLSGKAVVVLGLPRGGVPVAFEVAKSLQAPLDVLVVRKLGVPFQPELAFGAIGEDGVRVLNDDVVRGTHLDAAAMDAVERKQLIELQRRAERFRRGRDRIPLTGRIAVIVDDGIATGATAKAACQVARAHGADKVVLAVPIGPDDIVARFAGYADEVVCLATPALFFAVGQGYRNFTQTSDDEVVAFLDRAHRDFAEAGAIDAAADPPLRDEEVQVVAGPVPVAGHLTVPEKPRGIVVFAHGSGSSRHSIRNRYVAEVLTGAGFATLLFDLLTPEEERNRANVFDIELLASRLIDVTGWLATQPDTASLPVGYFGASTGAGAALVAAADPRVNVRAVVSRGGRPDLAGDSLGSVVAPTLLIVGGRDQVVLELNQRAQAVIPGKCQLTVVPGATHLFEEPGTLEQVAKLACDWFIDHLCGPGPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGP1</accession>
    <name>A0A7U8TGP1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898823.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425299"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="98" mass="11334" checksum="72DF33A68405AE4B" modified="2021-06-02" version="1">MARRRKPLHRQRPEPPSWALRRVEAGPDGHEYEVRPVAAARAVKTYRCPGCDHEIRSGTAHVVVWPTDLPQAGVDDRRHWHTPCWANRATRGPTRKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGQ1</accession>
    <name>A0A7U8TGQ1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cysteine synthase B cysM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_03521</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406912.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGQ1"/>
    <dbReference type="GeneID" id="45425314"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="8">
        <location>
            <begin position="9"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="6">
        <location>
            <begin position="184"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="323" mass="34438" checksum="B743231FEFA87573" modified="2021-06-02" version="1">MTRYDSLLQALGNTPLVGLQRLSPRWDDGRDGPHVRLWAKLEDRNPTGSIKDRPAVRMIEQAEADGLLRPGATILEPTSGNTGISLAMAARLKGYRLICVMPENTSVERRQLLELYGAQIIFSAAEGGSNTAVATAKELAATNPSWVMLYQYGNPANTDSHYCGTGPELLADLPEITHFVAGLGTTGTLMGTGRFLREHVANVKIVAAEPRYGEGVYALRNMDEGFVPELYDPEILTARYSVGAVDAVRRTRELVHTEGIFAGISTGAVLHAALGVGAGALAAGERADIALVVADAGWKYLSTGAYAGSLDDAETALEGQLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGQ3</accession>
    <name>A0A7U8TGQ3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit beta</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpD</name>
        <name evidence="14" type="ORF">TBLG_03492</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406701.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGQ3"/>
    <dbReference type="GeneID" id="45425284"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="13">
        <location>
            <begin position="163"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="171"/>
            <end position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="486" mass="53094" checksum="6D2937B2354DB766" modified="2021-06-02" version="1">MTTTAEKTDRPGKPGSSDTSGRVVRVTGPVVDVEFPRGSIPELFNALHAEITFESLAKTLTLEVAQHLGDNLVRTISLQPTDGLVRGVEVIDTGRSISVPVGEGVKGHVFNALGDCLDEPGYGEKFEHWSIHRKPPAFEELEPRTEMLETGLKVVDLLTPYVRGGKIALFGGAGVGKTVLIQEMINRIARNFGGTSVFAGVGERTREGNDLWVELAEANVLKDTALVFGQMDEPPGTRMRVALSALTMAEWFRDEQGQDVLLFIDNIFRFTQAGSEVSTLLGRMPSAVGYQPTLADEMGELQERITSTRGRSITSMQAVYVPADDYTDPAPATTFAHLDATTELSRAVFSKGIFPAVDPLASSSTILDPSVVGDEHYRVAQEVIRILQRYKDLQDIIAILGIDELSEEDKQLVNRARRIERFLSQNMMAAEQFTGQPGSTVPVKETIEAFDRLCKGDFDHVPEQAFFLIGGLDDLAKKAESLGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGQ5</accession>
    <name>A0A7U8TGQ5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribonuclease PH</fullName>
            <shortName evidence="4">RNase PH</shortName>
            <ecNumber evidence="4">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rph</name>
        <name evidence="7" type="ORF">TBLG_03525</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="4"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406926.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGQ5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="RNase_PH" evidence="5">
        <location>
            <begin position="12"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="6">
        <location>
            <begin position="161"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate (substrate) binding" evidence="4">
        <location>
            <begin position="126"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="259" mass="27351" checksum="D8461B3089929F9F" modified="2021-06-02" version="1">MSKREDGRLDHELRPVIITRGFTENPAGSVLIEFGHTKVLCTASVTEGVPRWRKATGLGWLTAEYAMLPSATHSRSDRESVRGRLSGRTQEISRLIGRSLRACIDLAALGENTIAIDCDVLQADGGTRTAAITGAYVALADAVTYLSAAGKLSDPRPLSCAIAAVSVGVVDGRIRVDLPYEEDSRAEVDMNVVATDTGTLVEIQGTGEGATFARSTLDKLLDMALGACDTLFAAQRDALALPYPGVLPQGPPPPKAFGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGU0</accession>
    <name>A0A7U8TGU0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Integration host factor mihF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGU0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="190" mass="20835" checksum="376672DCF96AF60D" modified="2021-06-02" version="1">MLGNTIHVPCQPCRHGHGAPSRGLRGRPADRWPVARATPTLHVCPQNQGVGLDFVRKPEYGRLRWPAYPAGTNNDRLISMRDGGIVALPQLTDEQRAAALEKAAAARRARAELKDRLKRGGTNLTQVLKDAESDEVLGKMKVSALLEALPKVGKVKAQEIMTELEIAPTRRLRGLGDRQRKALLEKFGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGV9</accession>
    <name>A0A7U8TGV9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Long-chain fatty-acid-CoA ligase fadD12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="48"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="448"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD13031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="535" mass="58000" checksum="154E3837A008CACD" modified="2021-06-02" version="1">MRIRQAFGLIATMRRAGLIAPLRPDRYLRIVAAMRREGMGFTAGFAGAARRCPDRPGLIDELGTLTWRQLDERGNALAAALQALPAGPPRVVGIMCRNHRGFVDALLAVNRIGAHILLLNTSFAGPALAEVVTREGVDTVVYDEEFSATVDRALAEKPQATRIVAWTDEDHDLTVEKLVAAHAGRRPEHTGSHGKVILLTSGTTGTPKGARHSGGGIGTLKAILDRTPWRAEEVTVIVAPMFHAWGFSQLVLASSLACTIVTRRRFDPEATLDLIDRHHATGLVVVPVMFDRIMDLPAEIRNRTTAGRCGSPPRRVLPLRPDVVIAFMDQFGDVIYNNYNATEAGMIATATPADLRTAPDTAGRPAEGTEIRILDQQFTEVPTGEVGTIYVRNDSQFDGYTSGAAKDFHAGFMSSGDVGYLDENGRLFVVGRDDEMIVSGGENIYPIEVEKTLATHPDVAEAAVIGVDDQQYGQRLAAFVVLKPGVSATPETLKQHVRDNLANYKVPRDIAVLDELPRGITGKILRTELQSRVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGW7</accession>
    <name>A0A7U8TGW7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 10">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="2 7 10">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pgk</name>
        <name evidence="12" type="ORF">TBLG_03625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 10">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="2 7 10"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900339.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGW7"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 8">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <begin position="360"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="412" mass="42512" checksum="0075CB4B607E65E6" modified="2021-06-02" version="1">MSVANLKDLLAEGVSGRGVLVRSDLNVPLDEDGTITDAGRIIASAPTLKALLDADAKVVVAAHLGRPKDGPDPTLSLAPVAVALGEQLGRHVQLAGDVVGADALARAEGLTGGDILLLENIRFDKRETSKNDDDRRALAKQLVELVGTGGVFVSDGFGVVHRKQASVYDIATLLPHYAGTLVADEMRVLEQLTSSTQRPYAVVLGGSKVSDKLGVIESLATKADSIVIGGGMCFTFLAAQGFSVGTSLLEDDMIEVCRGLLETYHDVLRLPVDLVVTEKFAADSPPQTVDVGAVPNGLMGLDIGPGSIKRFSTLLSNAGTIFWNGPMGVFEFPAYAAGTRGVAEAIVAATGKGAFSVVGGGDSAAAVRAMNIPEGAFSHISTGGGASLEYLEGKTLPGIEVLSREQPTGGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH10</accession>
    <name>A0A7U8TH10_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyprenyl-diphosphate synthase grcC1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402957.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH10"/>
    <dbReference type="GeneID" id="45424526"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="335" mass="35560" checksum="F4D7BF4FEE9D832F" modified="2021-06-02" version="1">MRTPATVVAGVDLGDAVFAAAVRAGVARVEQLMDTELRQADEVMSDSLLHLFNAGGKRFRPLFTVLSAQIGPQPDAAAVTVAGAVIEMIHLATLYHDDVMDEAQVRRGAPSANAQWGNNVAILAGDYLLATASRLVARLGPEAVRIIADTFAQLVTGQMRETRGTSENVDSIEQYLKVVQEKTGSLIGAAGRLGGMFSGATDEQVERLSRLGGVVGTAFQIADDIIDIDSESDESGKLPGTDVREGVHTLPMLYALRESGPDCARLRALLNGPVDDDAEVREALTLLRASPGMARAKDVLAQYAAQARHELALLPDVPGRRALAALVDYTVSRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH48</accession>
    <name>A0A7U8TH48_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402896.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH48"/>
    <dbReference type="GeneID" id="45424507"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021784">
        <property type="entry name" value="DUF3349"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11829">
        <property type="entry name" value="DUF3349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="100" mass="11312" checksum="B276B37B29D2FFE7" modified="2021-06-02" version="1">MNRFLTSIVAWLRAGYPEGIPPTDSFAVLALLCRRLSHDEVKAVANELMRLGDFDQIDIGVVITHFTDELPSPEDVERVRARLAAQGWPLDDVRDREEHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH55</accession>
    <name>A0A7U8TH55_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purF</name>
        <name evidence="12" type="ORF">TBLG_02954</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH55"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="35"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="527" mass="56162" checksum="A2FE9D1DD08FA572" modified="2021-06-02" version="1">MAVDSDYVTDRAAGSRQTVTGQQPEQDLNSPREECGVFGVWAPGEDVAKLTYYGLYALQHRGQEAAGIAVADGSQVLVFKDLGLVSQVFDEQTLAAMQGHVAIGHCRYSTTGDTTWENAQPVFRNTAAGTGVALGHNGNLVNAAALAARARDAGLIATRCPAPATTDSDILGALLAHGAADSTLEQAALDLLPTVRGAFCLTFMDENTLYACRDPYGVRPLSLGRLDRGWVVASETAALDIVGASFVRDIEPGELLAIDADGVRSTRFANPTPKGCVFEYVYLARPDSTIAGRSVHAARVEIGRRLARECPVEADLVIGVPESGTPAAVGYAQESGVPYGQGLMKNAYVGRTFIQPSQTIRQLGIRLKLNPLKEVIRGKRLIVVDDSIVRGNTQRALVRMLREAGAVELHVRIASPPVKWPCFYGIDFPSPAELIANAVENEDEMLEAVRHAIGADTLGYISLRGMVAASEQPTSRLCTACFDGKYPIELPRETALGKNVIEHMLANAARGAALGELAADDEVPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH68</accession>
    <name>A0A7U8TH68_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="55" mass="5973" checksum="7B6208D6B1431641" modified="2021-06-02" version="1">MAADPQCTRCKQTIEPGWLYITAHRRGQAGIVDDGAVLIHVPGECPHPGEHVPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH78</accession>
    <name>A0A7U8TH78_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02716</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403055.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TH78"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="Alpha_mannosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030751058" evidence="1">
        <location>
            <begin position="31"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92N" evidence="3">
        <location>
            <begin position="44"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_hydro_92" evidence="2">
        <location>
            <begin position="280"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="877" mass="92953" checksum="F37E5513F12B2C00" modified="2021-06-02" version="1">MRARRLRRALAALLAVAGLFVPFIVGVPTAYDGEPVFVAIPVEHVNTLIGTGTGAAIVGEINNFPGASVPFGMVQYSPDTVDNYAGYDYDNPHSTGFSMTHASVGCPAFGDISMLPTTTPLGSQPWSAWEEIAHDDTEVGVPGYYTVRFPGTGVIAELTATTRTGVGRFRYPRNGWPALFHVRSGASLAGNYAATLQIEDNTTITGSATSGGFCGKKNLYTVYFAMKFSQPFSSYGTWDGYAVYPGSHSMNSSYSGGYVGFPAGSVLEVRTALSYVSVDGARANLDAEGGASFDDIRAATSSEWNAALSRIAVAGRGPGDVDTFYTCLYRSLLHPNTFNDVDGRYIGFDGVIHSVASGHTHYANFSDWDTYRSLAPLQGLLFPQRASDMIQSLVTDAEQSGAYPRWALANSATGMMSGDSVVPLIVNLYAFGARDFDLKSALHYMVNAATQGGVGLDGFLERPGIAAYLRLGYGPQTAEFRANGRIAGASVTLEWSVDDFAISRFADSLGDTATAAVFQNRSQYWQNLFNPTTGYISPRSAAGFFPDGPGFVAYPSGFGQDGYDEGNAEQYLWWVPHNVAGLVTALGGRTAVVKRLDRFTKKLNVGPNEPYLWAGNEPGFGVPWLYNYIGQPWKTQRTVDRVRGLFGPTPGGAPGNDDLGALSSWYVWAALGLYPSTPGTTILTVNTPLFDRAVIALPTGKSIQITAPGASGRNRLKYIDGLTIDRQPSNQTFLPESIVRTGGDLTFSLAGTPNKVWGTAASAAPPSFGAGSSAVTVNIARPIIGIVPGATGTVTVDAQRMIDGVDDYTVTPTSYVVGIAAEPLSGQFDDDGAVSASVAITVARSVPSGYYPIYVTTSAGDSARTLIVLVVVAEAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THU6</accession>
    <name>A0A7U8THU6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ORF">TBLG_03110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898659.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THU6"/>
    <dbReference type="GeneID" id="45424920"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="387" mass="40926" checksum="C3155A7CCAF98FDC" modified="2021-06-02" version="1">MDLFEYQAKELFAKHNVPSTPGRVTDTAEGAKAIATEIGRPVMVKAQVKIGGRGKAGGVKYAATPQDAYEHAKNILGLDIKGHIVKKLLVAEASDIAEEYYLSFLLDRANRTYLAMCSVEGGMEIEEVAATKPERLAKVPVNAVKGVDLDFARSIAEQGHLPAEVLDTAAVTIAKLWELFVAEDATLVEVNPLVRTPDHKILALDAKITLDGNADFRQPGHAEFEDRAATDPLELKAKEHDLNYVKLDGQVGIIGNGAGLVMSTLDVVAYAGEKHGGVKPANFLDIGGGASAEVMAAGLDVVLGDQQVKSVFVNVFGGITSCDAVATGIVKALGMLGDEANKPLVVRLDGNNVEEGRRILTEANHPLVTLVATMDEAADKAAELASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI32</accession>
    <name>A0A7U8TI32_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved exported protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH_hydro" evidence="2">
        <location>
            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="314" mass="32879" checksum="FC20DF4ADA6D1C33" modified="2021-06-02" version="1">MPRRSTIALATAGALASTGTAYLGARNLLVGQATHARTVIPKSFDAPPRADGVYTRGGGPVQRWRREVPFDVHLMIFGDSTATGYGCASAEEVPGVLIARGLAEQTGKRIRLSTKAIVGATSKGVCGQVDAMFVVGPPPDAAVIMIGANDITALNGIGPSAQRLADCVRRLRTRGAVVVVGTCPDLGVITAIPQPLRALAHTRGVRLARAQTAAVKAAGGVPVPLGHLLAPKFRAMPELMFSADRYHPSAPAYALAADLLFLALRDALTEKLDIPIHETPSRPGTATLEPGHTRHSMMSRLRRPRPARAVPTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIM0</accession>
    <name>A0A7U8TIM0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,4-alpha-glucan branching enzyme GlgB</fullName>
            <ecNumber evidence="9">2.4.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-glucosyl-transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-(1-&gt;4)-glucan branching enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glycogen branching enzyme</fullName>
            <shortName evidence="9">BE</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">glgB</name>
        <name evidence="12" type="ORF">TBLG_03511</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="9"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIM0"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00685">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="PTHR43651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 9" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="5 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="11">
        <location>
            <begin position="259"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9 10">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EFD12927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="731" mass="81671" checksum="32FB2FEB0259DBC6" modified="2021-06-02" version="1">MSRSEKLTGEHLAPEPAEMARLVAGTHHNPHGILGAHEYGDHTVIRAFRPHAVEVVALVGKDRFSLQHLDSGLFAVALPFVDLIDYRLQVTYEGCEPHTVADAYRFLPTLGEVDLHLFAEGRHERLWEVLGAHPRSFTTADGVVSGVSFAVWAPNAKGVSLIGEFNGWNGHEAPMRVLGPSGVWELFWPDFPCDGLYKFRVHGADGVVTDRADPFAFGTEVPPQTASRVTSSDYTWGDDDWMAGRALRNPVNEAMSTYEVHLGSWRPGLSYRQLARELTDYIVDQGFTHVELLPVAEHPFAGSWGYQVTSYYAPTSRFGTPDDFRALVDALHQAGIGVIVDWVPAHFPKDAWALGRFDGTPLYEHSDPKRGEQLDWGTYVFDFGRPEVRNFLVANALYWLQEFHIDGLRVDAVASMLYLDYSRPEGGWTPNVHGGRENLEAVQFLQEMNATAHKVAPGIVTIAEESTSWPGVTRPTNIGGLGFSMKWNMGWMHDTLDYVSRDPVYRSYHHHEMTFSMLYAFSENYVLPLSHDEVVHGKGTLWGRMPGNNHVKAAGLRSLLAYQWAHPGKQLLFMGQEFGQRAEWSEQRGLDWFQLDENGFSNGIQRLVRDINDIYRCHPALWSLDTTPEGYSWIDANDSANNVLSFMRYGSDGSVLACVFNFAGAEHRDYRLGLPRAGRWREVLNTDATIYHGSGIGNLGGVDATDDPWHGRPASAVLVLPPTSALWLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIS2</accession>
    <name>A0A7U8TIS2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407272.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TIS2"/>
    <dbReference type="GeneID" id="45425376"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD13002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="85" mass="9444" checksum="007F5EF09DD30488" modified="2021-06-02" version="1">MKRTNIYLDEEQTASLDKLAAQEGVSRAELIRLLLNRALTTAGDDLASDLQAINDSFGTLRHLDPPVRRSGGREQHLAQVWRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR24</accession>
    <name>A0A7U8TR24_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase echA17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="137" mass="14238" checksum="D9BB85673CE1C670" modified="2021-06-02" version="1">MPEFVNVVVSDGSQDAGLAMLLLSRPPTNAMTRQVYREVVAAANELGRRDDVAAVILYGGHEIFSAGDDMPELRTLSAQEADTAARIRQQAVDAVAAIPKPTVAAITGYALGAGLTLALAADWRVSGDNVTADGQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR88</accession>
    <name>A0A7U8TR88_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="1">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901535.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427073"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="603" mass="66840" checksum="9EDB8CE3B97F2386" modified="2021-06-02" version="1">MANRPDIIIVMTDEERAVPPYESAEVLAWRQRSLTGRRWFDEHGISFTRHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKRFDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPATGAPLATNDNEGVVDSAAVRRYLDADPLGPYGFSGWVGPEPHGAGLANSGFRRDPLVADRVVAWLTERYARRRAGDTAAMRPFLLVASFVNPHDIVLFPAWVWRSPLKPSPLDPPHVPAAPTADEDLSTKPAAQVAYREAYYSGYGLTRMVSRNYARNAQRYRDLYYRLHAEVDGPIDRVRRAVTEGGSEDAMLVRTSDHGDLLGAHGGLHQKWFNLYDEATRVPFVIARIGEKATQPRTVSAPTSHVDLVPTLLSAAGVDVDVVAAALAESFSEVHPLPGRDLMPVVDGASADEGRAIYLMTRDNVLEGDTGASLLSRQLGRIVNPPAPLRIKVPAHVAANFEGLVVRVDDTDAAGGAGHLWKLVRTFDDPATWTEPGVRHLATNGMGGDAYRTDPLDDQWELYDLTADPIEAYNRWTDPQLHELRQHLRMLLKQQRAVSVPERNQPWPYAHRLPPSGASNGLVRRVLGRFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR91</accession>
    <name>A0A7U8TR91_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416410.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR91"/>
    <dbReference type="GeneID" id="45427130"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="133" mass="14386" checksum="57DF1E50B20F655D" modified="2021-06-02" version="1">MPDSSTALRILVYSDNVQTRERVMRALGKRLHPDLPDLTYVEVATGPMVIRQMDRGGIDLAILDGEATPTGGMGIAKQLKDELASCPPILVLTGRPDDTWLASWSRAEAAVPHPVDPIVLGRTVLSLLRAPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRA8</accession>
    <name>A0A7U8TRA8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Non-heme haloperoxidase hpx</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRA8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="24"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="299" mass="32146" checksum="ED3F637B3C133B5D" modified="2021-06-02" version="1">MTVRAADGTPLHTQVFGPPHGYPIVLTHGFVCAIRAWAYQIADLAGDYRVIAFDHRGHGRSGVPRRGAYSLNHLAADLDSVLDATLAPRERAVVAGHSMGGITIAAWSDRYRHKVRRRTDAVALINTTTGDLVRKVKLLSVPRELSPVRVLAGRSLVNTFGGFPLPGAARALSRHVISTLAVAADADPSATRLVYELFTQTSAAGRGGCAKMLVEEVGSAHLNLDGLTVPTLVIGGVRDRLTPISQSRRIARTAPNVVGLVELPGGHCSMLERHQEVNSHLRALAESVTRHVRDRRISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRC4</accession>
    <name>A0A7U8TRC4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome P450 141 cyp141</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03742</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003899925.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRC4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002397">
        <property type="entry name" value="Cyt_P450_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00359">
        <property type="entry name" value="BP450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="SSF48264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD14844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="400" mass="43732" checksum="C612759A4F1B85B5" modified="2021-06-02" version="1">MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAWLVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQGLNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPETVHELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQSTMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIVRFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPNEHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRD2</accession>
    <name>A0A7U8TRD2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRD2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="66" mass="7285" checksum="C6CDD5AC32B04A0E" modified="2021-06-02" version="1">MQEGGPQETMSARSTQHDAADALFRAIIETLDKHRNERTLTEDVLDTLARAYASISTNVPEQGRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRE4</accession>
    <name>A0A7U8TRE4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="183" mass="18316" checksum="680CC1A10D8A6A22" modified="2021-06-02" version="1">MSSPVSSRRLANLVKESLQGSVLGGVVSDAVLPAVSDDVKPGAGEDAYRVPVVVAAGSGAVVQVGGLEVGSAAVAGEVADTVAELFVCRPTEPDVGDFVGLAGGAGDAGQAGQQFGLGVGVRGESFGARRRLALSTVGASGATAGLRKTHDGHHGCQARGALTQRRLYIGNPSEITDTRMVHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN4</accession>
    <name>A0A7U8TRN4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417251.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRN4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="420" mass="45732" checksum="7CB3FA383D594DBB" modified="2021-06-02" version="1">MVADLVPIRLSLSAGDRYTLWAPRWRDAGDEWEAFLGKDDDLYGFESVSDLVAFVRTDTENDLVDHPAWQDLTGAHAHNLNPAEDNQFDLVVVEELLAEKPTAESVAALAASLAIVSAIGSVCELAAVSKFFNGNPILGTVSGGLEHFTGKAGNKRWNSIAEVIGRSWDDVLAAIDEIISTPEVDAELSEKVAEELAEEPEGAEEVAAEVEATQDTQEAAESDDEEADAPGDSVVLGGDRDFWLQVGIDPIQIMTGTATFYTLRCYLDDRPIFLGRNGRISVFGSERALARYLADEHDHDLSDLSTYDDIRTAATDGSLAVAVTDDNVYVLSGLVDDFADGPDAVDREQLDLAVELLRDIGDYSEDSAVDKALETTRPLGQLVAYVLDPHSVGKPTAPYAAAVREWEKLERFVESRLRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRR4</accession>
    <name>A0A7U8TRR4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF772" evidence="2">
        <location>
            <begin position="52"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="234" mass="25572" checksum="824A7E916CFA713F" modified="2021-06-02" version="1">MFRTVGDQASLWESVLPEELRRLPEELARVDALLDDSAFFCPFVPFFDPRMGRPSIPMETYLRLMFLKFRYRLGYESLCREVTDSITWRRFCRIPLEGSVPHPTTLMKLTTRCGEDAVAGLNEALLAKAASEKLLRTNKVRADTTVVEGDVGYPTDTGLLAKAVGSMARTVARIKAADAGSAPLGGSSGPRDRLQAAVTRRAATRSGAGLRAPDHRGASRDRRAGADRGCRGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRT6</accession>
    <name>A0A7U8TRT6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional protein FolD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="6">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="6">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">folD</name>
        <name evidence="9" type="ORF">TBLG_04045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="6"/>
    <dbReference type="EC" id="3.5.4.9" evidence="6"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="3 6" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THF_DHG_CYH" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="THF_DHG_CYH_C" evidence="8">
        <location>
            <begin position="123"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="281" mass="29514" checksum="15708DDB7A663B16" modified="2021-06-02" version="1">MGAIMLDGKATRDEIFGDLKQRVAALDAAGRTPGLGTILVGDDPGSQAYVRGKHADCAKVGITSIRRDLPADISTATLNETIDELNANPDCTGYIVQLPLPKHLDENATLERVDPAKDADGLHPTNLGRLVLGTPAPLPCTPRGIVHLLRRYDISIAGAHVVVIGRGVTVGRPLGLLLTRRSENATVTLCHTGTRDLPALTRQADIVVAAVGVAHLLTADMVRPGAAVIDVGVSRTDDGLVGDVHPDVWELAGHVSPNPGGVGPLTRAFLLTNVVELAERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRV3</accession>
    <name>A0A7U8TRV3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase echA18_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_04027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRV3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="82" mass="8616" checksum="A137FF80B9AADE7B" modified="2021-06-02" version="1">MVQKVVAPQDLAAATAKLVGQVCRQSAVTMRAAKVVANMHGRALTGADTDALIRFGVEAYEGADLREGVAAFSQGRPPKFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRV4</accession>
    <name>A0A7U8TRV4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_04090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="6">
        <location>
            <begin position="138"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD15196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="293" mass="31546" checksum="6C1F0BD1C11D58D5" modified="2021-06-02" version="1">MPVEVELASEFRYRDPVLDRSTLVVAISQSGETADTLEAVRHAKEQKAKVLAICNTNGSQIPRECDAVLYTRAGPEIGVASTKTFLAQIAANYLLGLALAQARGTKYPDEVEREYHELEAMPDLVARVIAATGPVAELAHRFAQSSTVLFLGRHVGYPVALEGALKLKELAYMHAEGFAAGELKHGPIALIEDGLPVIVVMPSPKGSATLHAKLLSNIREIQTRGAVTIVIAEEGDETVRPYADHLIEIPAVSTLLQPLLSTIPLQVFAASVARARGYDVDKPRNLAKSVTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRW2</accession>
    <name>A0A7U8TRW2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cutinase</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_04105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cutinase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRW2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 6" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031592259" description="Cutinase" evidence="6">
        <location>
            <begin position="42"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="262" mass="26504" checksum="1DE666FA938D3639" modified="2021-06-02" version="1">MNNRPIRLLTSGRAGLGAGALITAVVLLIALGAVWTPVAFADGCPDAEVTFARGTGEPPGIGRVGQAFVDSLRQQTGMEIGVYPVNYAASRLQLHGGDGANDAISHIKSMASSCPNTKLVLGGYSQGATVIDIVAGVPLGSISFGSPLPAAYADNVAAVAVFGNPSNRAGGSLSSLSPLFGSKAIDLCNPTDPICHVGPGNEFSGHIDGYIPTYTTQAASFVVQRLRAGSVPHLPGSVPQLPGSVLQMPGTAAPAPESLHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRW5</accession>
    <name>A0A7U8TRW5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">rplM</name>
        <name evidence="8" type="ORF">TBLG_04097</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 6">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418312.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRW5"/>
    <dbReference type="GeneID" id="45427433"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="147" mass="16337" checksum="0D2DB2622D62B626" modified="2021-06-02" version="1">MPTYAPKAGDTTRSWYVIDATDVVLGRLAVAAANLLRGKHKPTFAPNVDGGDFVIVINADKVAISGDKLQHKMVYRHSGYPGGLHKRTIGELMQRHPDRVVEKAILGMLPKNRLSRQIQRKLRVYAGPEHPHSAQQPVPYELKQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRX3</accession>
    <name>A0A7U8TRX3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpsI</name>
        <name evidence="9" type="ORF">TBLG_04096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="151" mass="16466" checksum="7C47C2A001C3FC9E" modified="2021-06-02" version="1">MTETTPAPQTPATPAGPAQSFVLERPIQTVGRRKEAVVRVRLVPGTGKFDLNGRSLEDYFPNKVHQQLIKAPLVTVDRVESFDIFAHLGGGGPSGQAGALRLGIARALILVSPEDRPALKKAGFLTRDPRATERKKYGLKKARKAPQYSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRX5</accession>
    <name>A0A7U8TRX5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PE" evidence="1">
        <location>
            <begin position="5"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="121" mass="12061" checksum="375ED19527260D37" modified="2021-06-02" version="1" fragment="single">MVMSLMVAPELVAAAAADLTGIGQAISAANAAAAGPTTQVLAAAGDEVSAAIAALFGTHAQEYQALSARVATFHEQFVRSLTAAGSAYATAEAANASPLQALEQQVLGAINAPTQLWLGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRY9</accession>
    <name>A0A7U8TRY9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MCE-family protein mce4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418972.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRY9"/>
    <dbReference type="GeneID" id="45427484"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="3">
        <location>
            <begin position="122"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="350" mass="36880" checksum="5FBF33230C98ACB0" modified="2021-06-02" version="1">MAGSGVPSHRSMVIKVSVFAVVMLLVAAGLVVVFGDFRFGPTTVYHATFTDASRLKAGQKVRIAGVPVGSVKAVKLNPDHSIDVAFAIDRSYTLYSSTRAVIRYENLVGDRFLEITSGPGELRKLPPGGTINVAHTQPALDLDALLGGLRPVLKGFDADKINTITSAVIELLQGQGGPLANVLADTGAFSAALGARDQLIGEVITNLNAVLATVDAKSAQFSASVDQLQQLVSGLAKNRDPIAGAISPLASTTTDLTELLRNSRRPLQGILENARPLATELDNRKAEVNNDIEQLGEDYLRLSALGSYGAFFNIYFCSVTIKINGPAGSDILLPIGGQPDPSKGRCAFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TSV7</accession>
    <name>A0A7U8TSV7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate formate lyase activating protein pflA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03759</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="72"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="362" mass="40445" checksum="C61D377B593035AD" modified="2021-06-02" version="1">MSDPFTIATKHWHRLHDSRIQCDVCPRACKLHEGQRGLCFVRGRFDDQVKLTSYGRSSGFCVDPIEKKPLNHFLLGSATLSFGTAGCNLACKFCQNWDISKSREIDVLASRAAPADIARTAHELGCRSVAFTYNDPTIFWEYAADVADACHDQGIKAVAVTAGYMCPEPRAEFYRRVDAANVDLKAFTEDFYRKVCVSHLRNVLDTLAYLRHQTNVWLEITTLLIPGRNDSDAEVAAECRWIRENLGVDVPVHFTAFHPDYKMMDTPATPPATLTRAREIGIGEGLRFVYTGNVHDAVGGSTSCPGCRATVIVRDWYSIRHYALTEDGRCQACGYQMPGVYDGPAGHWGQRRLPLLTSLSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT56</accession>
    <name>A0A7U8TT56_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416111.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TT56"/>
    <dbReference type="GeneID" id="45427098"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017517">
        <property type="entry name" value="CHP03083_actinobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010872">
        <property type="entry name" value="MDMPI_C-term_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024344">
        <property type="entry name" value="MDMPI_metal-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07398">
        <property type="entry name" value="MDMPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11716">
        <property type="entry name" value="MDMPI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109854">
        <property type="entry name" value="SSF109854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03083">
        <property type="entry name" value="TIGR03083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MDMPI_N" evidence="2">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="MDMPI_C" evidence="1">
        <location>
            <begin position="179"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="283" mass="30508" checksum="4D911C48EC39ED38" modified="2021-06-02" version="1">MTTPGRPLTTLDKSDVLAGLFAVWHSLDALLDGLLETDWQATSPLPGWDVKAVVSHIIGTESFLLGIAAPEPDTDVSALAHVRNPIGVMNECWVRHLGTESGVGLLERFRAVTSQRRKVLASLSDDEWNAPTTTPSGPDSYGRFMRIRIFDCWMHEQDIRAAVQRPSSDDELGGPASPLVLDEIAATMGFVVGKLAKAPDGSRVLLELTGPLSRSIRVSVDGRARVVDDFGGPAPTATIRLDGLQFTRLAGGRPMSPARSQDVELGGDKELAGHILERLNFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTG2</accession>
    <name>A0A7U8TTG2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thymidylate kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tmk</name>
        <name evidence="5" type="ORF">TBLG_03885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417036.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTG2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="4">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="214" mass="22635" checksum="E435123C250F46E7" modified="2021-06-02" version="1">MLIAIEGVDGAGKRTLVEKLSGAFRAAGRSVATLAFPRYGQSVAADIAAEALHGEHGDLASSVYAMATLFALDRAGAVHTIQGLCRGYDVVILDRYVASNAAYSAARLHENAAGKAAAWVQRIEFARLGLPKPDWQVLLAVSAELAGERSRGRAQRDPGRARDNYERDAELQQRTGAVYAELAAQGWGGRWLVVGADVDPGRLAATLAPPDVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTI5</accession>
    <name>A0A7U8TTI5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">TBLG_03916</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="7">
        <location>
            <begin position="76"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD15017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="272" mass="30079" checksum="F07597B96A0AB081" modified="2021-06-02" version="1">MNEVTAGVRELATAIMVSRHLTGVLAGHGSQTVTYHFASILCSSVHSLVVSFADATIARLPGVVQPYAQRHHELIKFAIVGGTTFIIDTAIFYTLKLTVLEPKPVTAKVIAGIVAVIASYVLNREWSFRDRGGRERHHEALLFFAFSGVGVLLSMAPLWFSSYILQLRVPTVSLTMENIADFISAYIIGNLLQMAFRFWAFRRWVFPDEFARNPDKALESALTAGGIAEVFEDVLEGGFEDGNVTLLRAWRNRANRFAQLGDSSEPRVSKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTW9</accession>
    <name>A0A7U8TTW9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cutinase cut4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418339.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTW9"/>
    <dbReference type="GeneID" id="45427442"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="PTHR33630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031309939" evidence="2">
        <location>
            <begin position="46"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="226" mass="23113" checksum="DA956ABFC1085AFE" modified="2021-06-02" version="1">MIPRPQPHSGRWRAGAARRLTSLVAAAFAAATLLLTPALAPPASAGCPDAEVVFARGTGEPPGLGRVGQAFVSSLRQQTNKSIGTYGVNYPANGDFLAAADGANDASDHIQQMASACRATRLVLGGYSQGAAVIDIVTAAPLPGLGFTQPLPPAADDHIAAIALFGNPSGRAGGLMSALTPQFGSKTINLCNNGDPICSDGNRWRAHLGYVPGMTNQAARFVASRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TU87</accession>
    <name>A0A7U8TU87_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NAD(P)H-hydrate epimerase</fullName>
            <ecNumber evidence="14">5.1.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">NAD(P)HX epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">nnrE</name>
        <name evidence="16" type="ORF">TBLG_04087</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 14">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="14">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.99.6" evidence="14"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="15">
        <location>
            <begin position="10"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="14">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="14">
        <location>
            <begin position="123"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFD15193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="361" mass="36293" checksum="24131AECAACC1F80" modified="2021-06-02" version="1">MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTARTGGVVGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKSGGRLVESVSAATDLVIDGVVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVATGAITGPAVHAALTVTFGGLKPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARWPVPGPRDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWPEVIASPTPAAAGRVQAWVVGPGLGTDEAGAAALWFALDTDLPVLVDADGLTMLADHPDLVAGRNAPTVLTPHAGEFAPAGRGAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y231</accession>
    <name>A0A7U8Y231_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rplA</name>
        <name evidence="11" type="ORF">TBLG_02778</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403292.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y231"/>
    <dbReference type="GeneID" id="45424601"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="3 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="235" mass="24756" checksum="2ECD7F4DBD7763BF" modified="2021-06-02" version="1">MSKTSKAYRAAAAKVDRTNLYTPLQAAKLAKETSSTKQDATVEVAIRLGVDPRKADQMVRGTVNLPHGTGKTARVAVFAVGEKADAAVAAGADVVGSDDLIERIQGGWLEFDAAIATPDQMAKVGRIARVLGPRGLMPNPKTGTVTADVAKAVADIKGGKINFRVDKQANLHFVIGKASFDEKLLAENYGAAIDEVLRLKPSSSKGRYLKKITVSTTTGPGIPVDPSITRNFAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y243</accession>
    <name>A0A7U8Y243_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="7">RNAP subunit beta'</shortName>
            <ecNumber evidence="7">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoC</name>
        <name evidence="11" type="ORF">TBLG_02808</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="7"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 7 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RPOLA_N" evidence="10">
        <location>
            <begin position="310"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="167"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="537"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="539"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="891"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="968"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="975"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="978"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1316" mass="146767" checksum="86DD57194C8C28AE" modified="2021-06-02" version="1">MLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITSVDEEMRHNELSTLEAEMAVERKAVEDQRDGELEVRAQKLEADLAELEAEGAKADARRKVRDGGEREMRQIRDRAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYFTGAMGAESIQKLIENFDIDAEAESLRDVIRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPEIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTEVPGDTGEYQPASGDHPETGVYSSPAEAIMAADRGVLSVRAKIKVRLTQLRPPVEIEAELFGHSGWQPGDAWMAETTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALREHYPDDNPIITIVDSGATGNFTQTRTLAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAERAPDGTLIRDPYIETSAYARTLGTDAVDEAGNVIVERGQDLGDPEIDALLAAGITQVKVRSVLTCATSTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVVYDKISKRQRLRVFKHEDGSERVLSDGDHVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFEAENRRVVAEGGEPAAGRPVLMGITKASLATDSWLSAASFQEATRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRNIAVQPTEEARAAAYTIPSYEDQYYSPDFGAATGAAVPLDDYGYSDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y289</accession>
    <name>A0A7U8Y289_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amino acid aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404139.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y289"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008696">
        <property type="term" value="F:4-amino-4-deoxychorismate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01559">
        <property type="entry name" value="ADCL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017824">
        <property type="entry name" value="Aminodeoxychorismate_lyase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="289" mass="31141" checksum="14A941455727FBED" modified="2021-06-02" version="1">MVVTLDGEILQPGMPLLHADDLAAVRGDGVFETLLVRDGRACLVEAHLQRLTQSARLMDLPEPDLPRWRRAVEVATQRWVASTADEGALRLIYSRGREGGSAPTAYVMVSPVPARVIGARRDGVSAITLDRGLPADGGDAMPWLMASAKTLSYAVNMAVLRHAARQGAGDVIFVSTDGYVLEGPRSTVVIATDGDQGGGNPCLLTPPPWYPILRGTTQQALFEVARAKGYDCDYRALRVADLFDSQGIWLVSSMTLAARVHTLDGRRLPRTPIAEVFAELVDAAIVSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2D1</accession>
    <name>A0A7U8Y2D1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">TBLG_03093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404792.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="87"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EFD12509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="338" mass="34793" checksum="10D7BA65D72F7F96" modified="2021-06-02" version="1">MLARAGEVGRAGPAIRWLGGIGAVIPLLALVLVLVVLVIEAMGAIRLNGLHFFTATEWNPGNTYGETVVTDGVAHPVGAYYGALPLIVGTLATSAIALIIAVPVSVGAALVIVERLPKRLAEAVGIVLELLAGIPSVVVGLWGAMTFGPFIAHHIAPVIAHNAPDVPVLNYLRGDPGNGEGMLVSGLVLAVMVVPIIATTTHDLFRQVPVLPREGAIALGMSNWECVRRVTLPWVSSGIVGAVVLGLGRALGETMAVAMVSGAVLGAMPANIYATMTTIAATIVSQLDSAMTDSTNFAVKTLAEVGLVLMVITLLTNVAARGMVRRVSRTALPVGRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2J2</accession>
    <name>A0A7U8Y2J2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02693</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402981.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2J2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="486" mass="54526" checksum="8A789FC6B8B2423B" modified="2021-06-02" version="1">MSVTPNAGCVDVVIVGAGISGLGAAYRIIERNPQLTYTILERRARIGGTWDLFRYPGVRSDSSIFTLSFPYEPWTREEGIADGAHIREYLTDMAHKYGIDRHIEFNSYVRAADWDSSTDTWTVTFEQNGVHKHYRSRFVFFGSGYYNYDEGYTPDFGGIEKFGGAVVHPQHWPEDLDYTGKKIVVIGSGATAVTLIPSLTDRAEKVTMLQRSPTYLISASKYSTFAAVVRKALPPKTSHLIVRMYNALLEAVFWFLSRKTPVFVKWLLRRTAIKNLPEGYDIETHFTPRYNPWDQRLCLIPDADLYNAITSGRAEVVTDHIDHFDATGIALKSGGHLDADIIVTATGLQLQALGGAAISLDGVEIDPRDRFVYKAHMLEDVPNLFWCVGYTNASWTLRADMTARATAKLLAHMAAHGHTRAAPHLGDEPMDEKPSWDIQAGYVKRAPYALPKSGTKRPWNVRQNYLADAIDYRFDRIEEAMVFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2M0</accession>
    <name>A0A7U8Y2M0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipase/esterase lipG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403314.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2M0"/>
    <dbReference type="GeneID" id="45424606"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="301" mass="32963" checksum="3599851BF54D1F9D" modified="2021-06-02" version="1">MDIRSGTAVSGDVKLYYEDMGDLDHPPVLLIMGLGAQMLLWRTDFCARLVAKGLRVIRYDNRDVGLSTKTERHRPGQPLATRLVRSWLGLPSQAAYTLEDMAADAAALLDHLDVKHAHVVGASMGGMIAQIFAARFAQRTKTLAVIFSSNNHRFLPPPAPRALLALLTGPPPDSPRDVIVDNAVRVSKIIGSPAYPIPEDQVRAEAAESYDRNFHPWGIAQQFSAILGSGSLLRYDRRIVAPTVVIHGRADKLMRPFGGRAVARAINGARLVLIDGMGHDLPRQLWDRVIGELTRNFSEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2M6</accession>
    <name>A0A7U8Y2M6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved membrane transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03437</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406359.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2M6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="218"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="419" mass="43287" checksum="69EA46BBFF653037" modified="2021-06-02" version="1">MRNSNRGPAFLILFATLMAAAGDGVSIVAFPWLVLQREGSAGQASIVASATMLPLLFATLVAGTAVDYFGRRRVSMVADALSGAAVAGVPLVAWGYGGDAVNVLVLAVLAALAAAFGPAGMTARDSMLPEAAARAGWSLDRINGAYEAILNLAFIVGPAIGGLMIATVGGITTMWITATAFGLSILAIAALQLEGAGKPHHTSRPQGLVSGIAEGLRFVWNLRVLRTLGMIDLTVTALYLPMESVLFPKYFTDHQQPVQLGWALMAIAGGGLVGALGYAVLAIRVPRRVTMSTAVLTLGLASMVIAFLPPLPVIMVLCAVVGLVYGPIQPIYNYVIQTRAAQHLRGRVVGVMTSLAYAAGPLGLLLAGPLTDAAGLHATFLALALPIVCTGLVAIRLPALRELDLAPQADIDRPVGSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Q6</accession>
    <name>A0A7U8Y2Q6_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EAL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406987.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Q6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="54"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="307" mass="33982" checksum="3DC597A6AB3BAC48" modified="2021-06-02" version="1">MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWADSDRDQVNTRHYLSTSMRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTLLPGRFIDRAENNGLMVPLTAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVLVEGVLGETGLPAHALQLELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAYLPRLPVDVVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQAARLRAFGCKAAQGWHFAKALPVDFFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2S2</accession>
    <name>A0A7U8Y2S2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02978</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030957750" evidence="1">
        <location>
            <begin position="44"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="4"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="77" mass="7630" checksum="89EF518DFBD1D843" modified="2021-06-02" version="1" fragment="single">MSYVSVLPATLATAATEVARIGSALSLASAVAAAQTSAVQAAAADEVSAAIAALFSAHGRDFQALSARAAAFHHEFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2S4</accession>
    <name>A0A7U8Y2S4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="7"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="244" mass="25533" checksum="753FFBDACCE15662" modified="2021-06-02" version="1" fragment="single">MTHMSIFLSRDNKVIVQGITGSEATVHTARMLRAGTQIVGGVNARKAGTTVTHEDKGGRLIKLPVFGSVAEAMEKTGADVSIIFVPPTFAKDAIIEAIDAEIPLLVVITEGIPVQDTAYAWAYNLEAGHKTRIIGPNCPGIISPGQSLAGITPANITGPGPIGLVSKSGTLTYQMMFELRDLGFSTAIGIGGDPVIGTTHIDAIEAFEKDPDTKLIVMIGEIGGDAEERAADFIKTNVSKPVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2S8</accession>
    <name>A0A7U8Y2S8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="113" mass="12678" checksum="491A062C2D8E63C6" modified="2021-06-02" version="1">MLLALLGGFERRGRWNVPKKLTTFTLWGSGVLDLRYADFTSTEVDIRAYSIMGAQTILLPPEVNVEIHGHRVMGGFDRKVVGEGTRGAPTVRIRGFSLWGDVGIKRKPRKPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2T2</accession>
    <name>A0A7U8Y2T2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyketide_cyc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2T2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide_cyc" evidence="1">
        <location>
            <begin position="2"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="134" mass="14831" checksum="78AC03E21EEF90D2" modified="2021-06-02" version="1">MEALADVGVLASWSPLHKQVEVIDYYPDGRPHHVRATVKILGLVDKEVLEYHWGPDWVCWDADQTFQQHGQHIEYTVKPEGVDRARVRFDITVEPAGPIPGFIVKRASEHVLDAAAKGLQKLIAGAGDQGNAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2X8</accession>
    <name>A0A7U8Y2X8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal-protein-alanine acetyltransferase rimJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2X8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="203" mass="22191" checksum="56FFCA47AEA85A51" modified="2021-06-02" version="1">MAVGPLRVSAGVIRLRPVRMRDGVHWSRIRLADRAHLEPWEPSADGEWTVRHTVAAWPAVCSGLRSEARNGRMLPYVIELDGQFCGQLTIGNVTHGALRSAWIGYWVPSAATGGGVATGALALGLDHCFGPVMLHRVEATVRPENAASRAVLAKVGFREEGLLRRYLEVDRAWRDHLLMAITVEEVYGSVASTLVRAGHASWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Y5</accession>
    <name>A0A7U8Y2Y5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405293.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Y5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="228" mass="24570" checksum="8EA202F49CFE3CF7" modified="2021-06-02" version="1">MPEAKRPESKRRSPASRPGKAGDSVRGGRATKPSAKPSTPAPHASRKTTRTPHEHIVEPIKRAITESVEKRSEQRLGFTARRAAILAAVVCVLTLTIARPVRTYFAQRAEMEQLAATEAMLRRQIADLEEQQVKLADPAYIAAQARERLGFVMPGDIPFQVQLPSTPLAPPQPGSDAATATNNEPWYTALWHTIADDPHLPPAAPPAPEPGRPGPLPPASPNPEQPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Z3</accession>
    <name>A0A7U8Y2Z3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low molecular weight T-cell antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406169.1">
        <property type="nucleotide sequence ID" value="NZ_KK338656.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Z3"/>
    <dbReference type="GeneID" id="45425146"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032407">
        <property type="entry name" value="MHB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016572">
        <property type="entry name" value="UCP010611"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010611">
        <property type="entry name" value="UCP010611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04529">
        <property type="entry name" value="MTB_hemophore"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030659242" evidence="1">
        <location>
            <begin position="29"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="110" mass="10881" checksum="0309DDB489150061" modified="2021-06-02" version="1">MRLSLTALSAGVGAVAMSLTVGAGVASADPVDAVINTTCNYGQVVAALNATDPGAAAQFNASPVAQSYLRNFLAAPPPQRAAMAAQLQAVPGAAQYIGLVESVAGSCNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y349</accession>
    <name>A0A7U8Y349_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406258.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y349"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041916">
        <property type="entry name" value="Anti_sigma_zinc_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="154" mass="16250" checksum="3EED07D9584F06AA" modified="2021-06-02" version="1">MADPGSVGHVFRRAFSWLPAQFASQSDAPVGAPRQFRSTEHLSIEAIAAFVDGELRMNAHLRAAHHLSLCAQCAAEVDDQSRARAALRDSHPIRIPSTLLGLLSEIPRCPPEGPSKGSSGGSSQGPPDGAAAGFGDRFADGDGGNRGRQSRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y351</accession>
    <name>A0A7U8Y351_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">YcaO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y351"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003776">
        <property type="entry name" value="YcaO-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02624">
        <property type="entry name" value="YcaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00702">
        <property type="entry name" value="TIGR00702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51664">
        <property type="entry name" value="YCAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YcaO" evidence="1">
        <location>
            <begin position="116"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="439" mass="47318" checksum="59AD3E179E56F63A" modified="2021-06-02" version="1">MTGRRLARFPAFRAGVAQDDDVGSTLSQGSTTGVLSGPNWSYWPSRVLGSADPTTIAHRHGTHRITSPDETWLALQPFLAPAGITRVADVTWLDCLGIPTVQAVRPASLTLSVSQGKAASYRAAQVSAVMESLEGWHAENVTADLWSATARDLEADLTYDPAQLRHRPGSLYHAGVKLDWMVATTLLTGRRTWVPWTAVLVNVATRDCWEPPMFEMDTTGLASGNCYDEATLHALYEVMERHSVAAAVAGETMFEVPTDDVAGSDSAHLVEMIRDAGDDVDLARIDVWDGYYCFAAELTSATLEVTFGGFGLHHDPNVALSRAITEAAQSRITAISGAREDLPSAIYHRFGRVHTYAKARKTSLRLNRARPTPWRVPDVDSLPELVASAATAVANRSGTEPLAVVCDFADACVPVVKVLAPGLVLSSASPMRTPLQEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y374</accession>
    <name>A0A7U8Y374_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="ORF">TBLG_03488</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cell membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898818.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y374"/>
    <dbReference type="GeneID" id="45425280"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028987">
        <property type="entry name" value="ATP_synth_B-like_membr_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81573">
        <property type="entry name" value="SSF81573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFD12904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="171" mass="18325" checksum="05C53BF84D8F4B81" modified="2021-06-02" version="1">MGEVSAIVLAASQAAEEGGESSNFLIPNGTFFVVLAIFLVVLAVIGTFVVPPILKVLRERDAMVAKTLADNKKSDEQFAAAQADYDEAMTEARVQASSLRDNARADGRKVIEDARVRAEQQVASTLQTAHEQLKRERDAVELDLRAHVGTMSATLASRILGVDLTASAATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4L8</accession>
    <name>A0A7U8Y4L8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="110" mass="12247" checksum="8DEB708CEBFCFF61" modified="2021-06-02" version="1">MTTSQYAAVAAAHSVDPDRWQAEFSAVLDRIAPRFARHQPLRHAGELMAGMVSGLDRKNCWTIAEHRGDTTPMGCSICWHGPAGTPTMSVTICVTIAIDRWRRTRPPVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4P4</accession>
    <name>A0A7U8Y4P4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alternative RNA polymerase sigma factor sigE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03397</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406257.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4P4"/>
    <dbReference type="GeneID" id="45425191"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009628">
        <property type="term" value="P:response to abiotic stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="5">
        <location>
            <begin position="87"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="6">
        <location>
            <begin position="186"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="257" mass="28877" checksum="E7AB77CAECBF6CE7" modified="2021-06-02" version="1">MELLGGPRVGNTESQLCVADGDDLPTYCSANSEDLNITTITTLSPTSMSHPQQVRDDQWVEPSDQLQGTAVFDATGDKATMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMEALPEDYDRVPADEPNPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDYLAAHPEHGECAVHVNPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4W7</accession>
    <name>A0A7U8Y4W7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003908693.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4W7"/>
    <dbReference type="GeneID" id="45425412"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="45" mass="4606" checksum="108F5642A7C03EAB" modified="2021-06-02" version="1">MRASPAERVDGAYAGAGPHTQSVLEEDQRQRAPAGAEAEGPGRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4X0</accession>
    <name>A0A7U8Y4X0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Serine protease htrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03399</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898779.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4X0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="4">
        <location>
            <begin position="440"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="528" mass="54190" checksum="F9C4C6FD6C87BCB3" modified="2021-06-02" version="1">MDTRVDTDNAMPARFSAQIQNEDEVTSDQGNNGGPNGGGRLAPRPVFRPPVDPASRQAFGRPSGVQGSFVAERVRPQKYQDQSDFTPNDQLADPVLQEAFGRPFAGAESLQRHPIDAGALAAEKDGAGPDEPDDPWRDPAAAAALGTPALAAPAPHGALAGSGKLGVRDVLFGGKVSYLALGILVAIALVIGGIGGVIGRKTAEVVDAFTTSKVTLSTTGNAQEPAGRFTKVAAAVADSVVTIESVSDQEGMQGSGVIVDGRGYIVTNNHVISEAANNPSQFKTTVVFNDGKEVPANLVGRDPKTDLAVLKVDNVDNLTVARLGDSSKVRVGDEVLAVGAPLGLRSTVTQGIVSALHRPVPLSGEGSDTDTVIDAIQTDASINHGNSGGPLIDMDAQVIGINTAGKSLSDSASGLGFAIPVNEMKLVANSLIKDGKIVHPTLGISTRSVSNAIASGAQVANVKAGSPAQKGGILENDVIVKVGNRAVADSDEFVVAVRQLAIGQDAPIEVVREGRHVTLTVKPDPDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y512</accession>
    <name>A0A7U8Y512_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Drugs-transport transmembrane ATP-binding protein ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03534</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900322.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y512"/>
    <dbReference type="GeneID" id="45425328"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="332"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="366"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="579" mass="60954" checksum="46FA562CB22AE7D8" modified="2021-06-02" version="1">MIRTWIALVPNDHRARLIGFALLAFCSVVARAVGTVLLVPLMAALFGEAPQRAWLWLGWLSAATVAGWVLDAVTARIGIELGFAVLNHTQHDVADRLPVVRLDWFTAENTATARQAIAATGPELVGLVVNLVTPLTSAILLPAVIALALLPISWQLGVAALAGVPLLLGALWASAAFARRADTAADKANTALTERIIEFARTQQALRAARRVEPARSLVGNALASQHTATMRLLGMQIPGQLLFSIASQLALIVLAGTTAALTITGTLTVPEAIALIVVMVRYLEPFTAVSELAPALESTRATLGRIGSVLTAPVMVAGSGTWRDGAVVPRIEFDDVAFGYDGGSGPVLDGVSFCLQPGTTTAIVGPSGCGKSTILALIAGLHQPTRGRVLIDGTDVATLDARAQQAVCSVVFQHPYLFHGTIRDNVFAADPGASDDQFAQAVRLARVDELIARLPDGANTIVGEAGSALSGGERQRVSIARALLKAAPVLLVDEATSALDAENEAAVVDALAADPRSRTRVIVAHRLASIRHADRVLFVDDGRVVEDGSISELLTAGGRFSQFWRQQHEAAEWQILAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7D4</accession>
    <name>A0A7U8Y7D4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="495" mass="55504" checksum="8F895DADF99E30F7" modified="2021-06-02" version="1">MNQHFDVLIIGAGLSGIGTACHVTAEFPDKTIALLERRERLGGTWDLFRYPGVRSDSDMFTFGYKFRPWRHVKVLADGASIRQYIADTATEFGVDEKIHYGLKVNTAEWSSRQCRWTVAGVHEATGETRTYTCDYLISCTGYYNYDAGYLPDFPGVHRFGGRCVHPQHWPEDLDYSGKKVVVIGSGATAVTLVPAMAGSNPGSAAHVTMLQRSPSYIFSLPAVDKISEVLGRFLPDRWVYEFGRRRNIAIQRKLYQACRRWPKLMRRLLLWEVRRRLGRSVDMSNFTPNYLPWDERLCAVPNGDLFKTLASGAASVVTDQIETFTEKGILCKSGREIEADIIVTATGLNIQMLGGMRLIVDGAEYQLPEKMTYKGVLLENAPNLAWIIGYTNASWTLKSDIAGAYLCRLLRHMADNGYTVATPRDAQDCALDVGMFDQLNSGYVKRGQDIMPRQGSKHPWRVLMHYEKDAKILLEDPIDDGVLHFAAAAQDHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7N0</accession>
    <name>A0A7U8Y7N0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyprenyl synthetase idsB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_04018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7N0"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="350" mass="36390" checksum="CD2841898CDE9A26" modified="2021-06-02" version="1">MGGVLTLDAAFLGSVPADLGKALLERARADCGPVLHRAIESMREPLATMAGYHLGWWNADRSTAAGSSGKYFRAALVYAAAAACGGDVGDATPVSAAVELVHNFTLLHDDVMDGDATRRGRPTVWSVWGVGGAILLGDALHATAVRILTGLTDECVAVRAIRRLQMSCLDLCIGQFEDCLLEGQPEVTVDDYLRMAAGKTAALTGCCCALGALVANADDATIAALERFGHELGLAFQCVDDLIGIWGDPGVTGKPVGNDLARRKATLPVVAALNSRSEAATELAALYQAPAAMTASDVERATALVKVAGGGHVAQRCADERIQAAIAALPDAVRSPDLIALSQLICRREC</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7T2</accession>
    <name>A0A7U8Y7T2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein beta subunit fixA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415921.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7T2"/>
    <dbReference type="GeneID" id="45427021"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000049">
        <property type="entry name" value="ET-Flavoprotein_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01065">
        <property type="entry name" value="ETF_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="5">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="266" mass="28081" checksum="1510562234CD5D82" modified="2021-06-02" version="1">MTNIVVLIKQVPDTWSERKLTDGDFTLDREAADAVLDEINERAVEEALQIREKEAADGIEGSVTVLTAGPERATEAIRKALSMGADKAVHLKDDGMHGSDVIQTGWALARALGTIEGTELVIAGNESTDGVGGAVPAIIAEYLGLPQLTHLRKVSIEGGKITGERETDEGVFTLEATLPAVISVNEKINEPRFPSFKGIMAAKKKEVTVLTLAEIGVESDEVGLANAGSTVLASTPKPAKTAGEKVTDEGEGGNQIVQYLVAQKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7W3</accession>
    <name>A0A7U8Y7W3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Two component system sensor histidine kinase devS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7W3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="496"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="578" mass="62229" checksum="1B2C1C2475E85B06" modified="2021-06-02" version="1">MTTGGLVDENDGAAMRPLRHTLSQLRLHELLVEVQDRVEQIVEGRDRLDGLVEAMLVVTAGLDLEATLRAIVHSATSLVDARYGAMEVHDRQHRVLHFVYEGIDEETVRRIGHLPKGLGVIGLLIEDPKPLRLDDVSAHPASIGFPPYHPPMRTFLGVPVRVRDESFGTLYLTDKTNGQPFSDDDEVLVQALAAAAGIAVANARLYQQAKARQSWIEATRDIATELLSGTEPATVFRLVAAEALKLTAADAALVAVPVDEDMPAADVGELLVIETVGSAVASTVGRTIPVAGAVLREVFVNGIPRRVDRVDLEGLDELADAGPALLLPLRARGTVAGVVVVLSQGGPGAFTDEQLEMMAAFADQAALAWQLATSQRRMRELDVLTDRDRIARDLHDHVIQRLFAIGLALQGAVPHERNPEVQQRLSDVVDDLQDVIQEIRTTIYDLHGASQGITRLRQRIDAAVAQFADSGLRTSVQFVGPLSVVDSALADQAEAVVREAVSNAVRHAKASTLTVRVKVDDDLCIEVTDNGRGLPDEFTGSGLTNLRQRAEQAGGEFTLASVPGASGTVLRWSAPLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Y6</accession>
    <name>A0A7U8Y7Y6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane cation transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7Y6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="2">
        <location>
            <begin position="149"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="355" mass="38133" checksum="58A103CB1F5C1CB9" modified="2021-06-02" version="1">MAGSWRRLRGLDEKLTAQPGYALVGVLRIPQRRASPARVISRRVVVAVVALLLTAGIVYVDRDGYLDAQGDRLTFLDCLYYAAVTLSTTGYGDITPISEFARAINIFVITPLRIAFLILLVGTTLEVLTETSRQAYKIQRWRSRVRNHTVVIGYGTKGKTAVAAMVSDELVPGEIVVVDTDSGVLERAAAAGLVTVHGDATKSDVLRLAGTQHASSIIVATSRDDTAVLVTLTAREIAPKAKIVASIREAENQHLLRQSGADTVVVSSETAGRLLGIATTTPSVVEMIEDLLTPEAGLAVAEREVEQAEVGGSPRHLRDIVLGVVRDGQLLRIGAPEVDAIEASDRLLYIRQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y845</accession>
    <name>A0A7U8Y845_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="9" type="ORF">TBLG_03886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417039.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y845"/>
    <dbReference type="GeneID" id="45427242"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="253"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="219"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="282"/>
            <end position="287"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="361"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD14988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="495" mass="54324" checksum="386EF292620E7327" modified="2021-06-02" version="1">MTGNLVTKNSLTPDVRNGIDFKIADLSLADFGRKELRIAEHEMPGLMSLRREYAEVQPLKGARISGSLHMTVQTAVLIETLTALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPDEPKGVPVFAWKGETLEEYWWAAEQMLTWPDPDKPANMILDDGGDATMLVLRGMQYEKAGVVPPAEEDDPAEWKVFLNLLRTRFETDKDKWTKIAESVKGVTEETTTGVLRLYQFAAAGDLAFPAINVNDSVTKSKFDNKYGTRHSLIDGINRGTDALIGGKKVLICGYGDVGKGCAEAMKGQGARVSVTEIDPINALQAMMEGFDVVTVEEAIGDADIVVTATGNKDIIMLEHIKAMKDHAILGNIGHFDNEIDMAGLERSGATRVNVKPQVDLWTFGDTGRSIIVLSEGRLLNLGNATGHPSFVMSNSFANQTIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGHLTKLTKEQAEYLGVDVEGPYKPDHYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y862</accession>
    <name>A0A7U8Y862_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1338 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417184.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y862"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16348">
        <property type="entry name" value="VOC_YdcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009770">
        <property type="entry name" value="DUF1338"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07063">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01150">
        <property type="entry name" value="DUF1338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1338" evidence="1">
        <location>
            <begin position="13"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="415" mass="45332" checksum="0D9612154C265130" modified="2021-06-02" version="1">MSRSKRLQTGQLRARFAAGLSAMYAAEVPAYGTLVEVCAQVNSDYLTRHRRAERLGSLQRVTAERHGAIRVGNPAELAAVADLFAAFGMLPVGYYDLRTAESPIPVVSTAFRPIDANELAHNPFRVFTSMLAIEDRRYFDADLRTRVQTFLARRQLFDPALLAQARAIAADGGCDADDAPAFVAAAVAAFALSREPVEKSWYDELSRVSAVAADIAGVGSTHINHLTPRVLDIDDLYRRMTERGITMIDTIQGPPRTDGPDVLLRQTSFRALAEPRMFRDEDGTVTPGILRVRFGEVEARGVALTPRGRERYEAAMAAADPAAVWATHFPSTDAEMAAQGLAYYRGGDPSAPIVYEDFLPASAAGIFRSNLDRDSQTGDGPDDAGYNVDWLAGAIGRHIHDPYALYDALAQEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y871</accession>
    <name>A0A7U8Y871_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease VapC</fullName>
            <shortName evidence="7">RNase VapC</shortName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">vapC</name>
        <name evidence="9" type="ORF">TBLG_03961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417282.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y871"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045926">
        <property type="term" value="P:negative regulation of growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006226">
        <property type="entry name" value="Mtu_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00028">
        <property type="entry name" value="Mtu_PIN_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0800">Toxin</keyword>
    <keyword evidence="2 7" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="8">
        <location>
            <begin position="4"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="142" mass="15834" checksum="07FF3749A80AE028" modified="2021-06-02" version="1">MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFWSCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y895</accession>
    <name>A0A7U8Y895_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04036</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="341"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="481" mass="51547" checksum="011BAD1174797438" modified="2021-06-02" version="1">MTMFARPTIPVAAAASDISAPAQPARGKPQQRPPSWSPRNWPVRWKVFTIALLPLVVAMVLAGLRVEAAMASTSGLRLVAARAEMIPAITKYMSALDVAVLASSTGHDVEGAQKNFTARKYELQTRLADTDVIADVRSGVNTLLNGGQALLDKVLADSIGLRDRVTAYAPLLLTAQNVIDASVRVDSEQIRTQVQGLSRAVGARGQMTMQEILVTRGADLAEPQLRSAMVTLAGTEPSTLFGMSAALGAGSPDTKNLQQQMVTRMAIMSDPAVALVNNPELLHSIQITRDIAEQVITDTTEAVTKSVQSQATDRRDAAIRDAVLVLAAIATAIVVVLVVARTLVGPMRVLRDGALKVAHTDLDGEIAAVRAGDEPIPEPLAVYTTEEIGQVAHAVDELHTRALLLAGEETRLRLLVNEMFETMSRRSRSLVDQQLSVIDQLERNEEDPARLDSLFPARSPGRPAAPQQRQPAGAGRCADYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y8C0</accession>
    <name>A0A7U8Y8C0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015209">
        <property type="term" value="F:cytosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030191">
        <property type="entry name" value="CodB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30569">
        <property type="entry name" value="PTHR30569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="561" mass="60656" checksum="362F249BE44F5351" modified="2021-06-02" version="1">MPGVITNSESPTAADHDRITATRETLEDYTLRLAPRSYRRWPPAVVGISALGGIAYLADFAIGANVGITWGTANALCGIAIFALVVFVTGLPLAYYAARYNIDLDLITRGSGFGYYGSVVTNVIFATFTFIFFALEGSIMAQGLKLGLHIPLWAGYACSTLIIFPLVVYGMKVLSQLQLWTTPLWLILMAAPFGYLVVSHPDSIGQFFSYAGKDGHGGLSFGSVLLAAGVCLSLIAQIAEQIDYLRFMPPRTPENANRWWTWTLLAGPGWVAFGATKQIIGLFLAVYLMANIPGSSTIANQPVHQFMQIYRTFVPGWLALTLAVILVVLSQIKINVTNAYSGSLAWTNSFTRLTKHYPGRVVFLGVNLAIALILMEANMFDFLNTILGCYANCGMAWVVAVASDIGFNKYLLGLSPKTPEFRRGMLYAINPVGFGSLLLAAGLSIVTFFGGLGAALQPYSPLVAIVTALVMPPILAAATKGKYYLRRTHDGIDLPMYDEHGNPSAAVLTCHVCHQDFERPDMLACQTHGAHVCSLCLSTDKQAEHVLPGLARAHIPGDQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9Y1</accession>
    <name>A0A7U8Y9Y1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-damage-inducible protein P dinP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03677</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="5">
        <location>
            <begin position="9"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="346" mass="37608" checksum="E35AD473AA919684" modified="2021-06-02" version="1">MPTAAPRWILHVDLDQFLASVELLRHPELAGLPVIVGGNGDPTEPRKVVTCASYEARAYGVRAGMPLRTAARRCPEATFLPSNPAAYNAASEEVVALLRDLGYPVEVWGWDEAYLAVAPGTPDDPIEVAEEIRKVILSQTGLSCSIGISDNKQRAKIATGLAKPAGIYQLTDANWMAIMGDRTVEALWGVGPKTTKRLAKLGINTVYQLAHTDSGLLMSTFGPRTALWLLLAKCGGDTEVSAQAWVPRSRSHAVTFPRDLTCRSEMESAVTELAQRTLNEVVASSRTVTRVAVTVRTATFYTRTKIRKLQAPSTDPDVITAAARHVLDLFELDRPVRLLGVRLELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y9Z7</accession>
    <name>A0A7U8Y9Z7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">TBLG_03722</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416117.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y9Z7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="10 14" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="13">
        <location>
            <begin position="57"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="12">
        <location>
            <begin position="200"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD14824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="297" mass="32819" checksum="67E5304E104BECA7" modified="2021-06-02" version="1">MRFGFLLNEVLTGFRRNVTMTIAMILTTAISVGLFGGGMLVVRLADSSRAIYLDRVESQVFLTEDVSANDSSCDTTACKALREKIETRSDVKAVRFLNRQQAYDDAIRKFPQFKDVAGKDSFPASFIVKLENPEQHKDFDTAMKGQPGVLDVLNQKELIDRLFAVLDGLSNAAFAVALVQAIGAILLIANMVQVAAYTRRTEIGIMRLVGASRWYTQLPFLVEAMLAATMGVGIAVAGLMVVRALFLENALNQFYQANLIAKVDYADILFITPWLLLLGVAMSGLTAYLTLRLYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA29</accession>
    <name>A0A7U8YA29_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="PTHR43756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="6">
        <location>
            <begin position="53"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD14886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="382" mass="42548" checksum="47D62ED9EFDFF988" modified="2021-06-02" version="1">MLSTDNRAELGDILTDIGDYLDDNPPALSLPPAAYTSSELWQLERERIFNRSWMLVAHVDQLAKTGDYVTVSVAGEPVMVVRDVDGQLHALSPICRHRLMLMVEPGAGRIDTLTCQYHLWRYGLDGRLRGAPHMAANLDFNRRECRLPQFAVATWNGLVWINLDADAEPIAAHLDLTDDEFAGYRLGEMVQVESWSHEWRANWKVAAENGHENYHVLGLHRQTLEPFVPGGGDLDVRQYSRWALRLRVPFTVPVEAKSLQLNEVQKSNLVVLWTFPNSALAIAGERVVWFGFIPQSIDRVQVLGGVLTTPELAADAAATAQTSQFVMAMINYEDRLGLEAVQVGAGSRFAERGHLSSKEWPGMLAFYRNLAIALVGDHPGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA80</accession>
    <name>A0A7U8YA80_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator, tetR-family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417200.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA80"/>
    <dbReference type="GeneID" id="45427290"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="221" mass="24805" checksum="E724D09A71EB9148" modified="2021-06-02" version="1">MATARRRLSPQDRRAELLALGAEVFGKRPYDEVRIDEIAERAGVSRALMYHYFPDKRAFFAAVVKDEADRLYAATNKAPAPGMTMFEEIRTGVLAYMAYHQQNPEAAWAAYVGLGRSDPVLLGIDDEAKNRQMEHIMSRIAEVVSGIDRDNTLDPEVERDLRVIIHGWLAFTFELCRQRIMDPSTDAERLADACAHALLDAISRLPQIPAELADAMATARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA91</accession>
    <name>A0A7U8YA91_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">MoaD-moaE fusion protein moaX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417290.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YA91"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00756">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036563">
        <property type="entry name" value="MoaE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003448">
        <property type="entry name" value="Mopterin_biosynth_MoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02391">
        <property type="entry name" value="MoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54690">
        <property type="entry name" value="SSF54690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD15066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="221" mass="24050" checksum="5E76414D5A86E144" modified="2021-06-02" version="1">MITVNVLYFGAVREACKVAHEKISLESGTTVDGLVDQLQIDYPPLADFRKRVRMAVNESIAPASTILDDGDTVAFIPQVAGGSDVYCRLTDEPLSVDEVLNAISGPSQGGAVIFVGTVRNNNNGHEVTKLYYEAYPAMVHRTLMDIIEECERQADGVRVAVAHRTGELRIGDAAVVIGASAPHRAAAFDAARMCIERLKQDVPIWKKEFALDGVEWVANRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF47</accession>
    <name>A0A7U8TF47_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyltransferase/methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900173.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF47"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="8"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="111"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="339" mass="37143" checksum="C3C22866A6DB5865" modified="2021-06-02" version="1">MELSPDRIMAIGGGYGPSKVLLTAVGLGLFTELGDEAMTAEAIADRLGLLKRPAIDFLDALVSLDLLARDGDGPGSHYRNTPETAHFLDEARPTYAGGLLKIWNERNYRFWADLTEALKTGKAQSEVKQTGRPFFEALYADPRRLEAFMAAMDAASRRNIELLAKRFPFERYRRLCDVGCADGLLSRIVAAAHPHLQCVSFDLPAVTEIARRKLTAEGLGERVQACAGDFLADPLPAADVITMGQILHDWNLDRKQQLVAKAYEALSKEGAFIVIETLIDDARRENTTGLMMSLNMLIEFGDAFDYSAADFRGWCGEAGFRSFEVIPLAGGSSAAVAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF49</accession>
    <name>A0A7U8TF49_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003402995.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF49"/>
    <dbReference type="GeneID" id="45424534"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015035">
        <property type="entry name" value="DUF1918"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08940">
        <property type="entry name" value="DUF1918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1918" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="88" mass="9523" checksum="F3AE5CEAA9B4D7A9" modified="2021-06-02" version="1">MKAKVGDWLVIKGATIDQPDHRGLIIEVRSSDGSPPYVVRWLETDHVATVIPGPDAVVVTAEEQNAADERAQHRFGAVQSAILHARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF80</accession>
    <name>A0A7U8TF80_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403184.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF80"/>
    <dbReference type="GeneID" id="45424570"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011660">
        <property type="entry name" value="VapB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07704">
        <property type="entry name" value="PSK_trans_fac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="81" mass="8813" checksum="5E1A13D33C10DE65" modified="2021-06-02" version="1">MALNIKDPSVHQAVKQIAKITGESQARAVATAVNERLARLRSDDLAARLLAIGHKTASRMSPEAKRLDHDALLYDERGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF81</accession>
    <name>A0A7U8TF81_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Two component system sensor kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02732</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900973.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TF81"/>
    <dbReference type="GeneID" id="45424568"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="168" mass="17854" checksum="FE299CAFE5204F04" modified="2021-06-02" version="1">MPITPLLHESVARFAATGADITTRAEPDLFVSIDPDHLRRILTAVLDNAITHGDGEIAVTAHARDGAVDIGVRDHGPGFADHFLPVAFDRFTRADTARGGRGSGLGLAIVAALTTTHGGHANATNHPDGGAELRITLPTPRPPFHEELPRITSSDTKDPNREHDTSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TF83</accession>
    <name>A0A7U8TF83_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="75" mass="8035" checksum="929396B8710EA37F" modified="2021-06-02" version="1">MEGQRLWAHRRPKGTGSAVIDVSLARRCEAHGYDYFRSVDPVAAAGFVVSAVWSCGRGPGNATGSGRLPKPLRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFB5</accession>
    <name>A0A7U8TFB5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arylsulfatase atsD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="PTM">
        <text evidence="3">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFB5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase" evidence="4">
        <location>
            <begin position="43"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600917-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="787" mass="86070" checksum="4E97F8E51CECB047" modified="2021-06-02" version="1">MPQPRTHLPIPSAARTGLITYDAKDPDSTYPPIEQLRPPAGAPNVLLILLDDVGFGASSAFGGPCRTSTAELLAGNGLRYNRFHTTALCSPTRQALLTGRNHHSAGMGGITEIATGAPGYSSVLPNTMSPIARTLKLNGYNTAQFGKCHEVPVWQTSPVGPFDAWPSGGGGFEYFYGFIGGEANQWYPSLYEGTTPVEVNRTPEEGYHFMADMTDKALGWIGQQKALAPDRPFFVYFAPGATHAPHHVPREWADKYRGRFDVGWDALREETFARQKELGVIPADCQLTARHAEIPAWDDMPEDLKPVLCRQMEVYAGFLEYTDHHVGRLVDGLQRLGVLDDTLVFYIIGDNGASAEGTINGTYNEMLNFNGLADIETPRFMTDRLDKFGGPESYNHYSVGWAHAMDTPYQWTKQVASHWGGTRNGTIVHWPNGIAAKGEMRWQFHHVIDVAPTILEAAGLPEPLFVNGVQQHPIEGVSMAYSFDDAQAPDRHETQYFEMFGNRGIYHKGWTAVTKHKTPWILVGEQTVAFDDDVWELYDTTKDWSQAKDLAKEMPEKLHELQRLWLIEATRYNVLPLDDDTASRINPDLAGRPVLIRGNTQVLFSNMGRLSENCVLNLKNKSHTVTAEVEVPETGAEGVIVAQGASIGGWSLYANDGKLKYCYNLGGIKHFYAESADPLPAGAHQVRMEFAYAGGGLGKGGEVTLYVDGQQVGEGHVEATLAIVFSADDGCDVGMDSGSPVSPDYAPGSNAFNGRIKGVQLAIAEAAAAAGHLVDPEHAIRIALARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFC9</accession>
    <name>A0A7U8TFC9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase echA5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02817</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403433.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFC9"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="263" mass="27441" checksum="7A44666E5445B6E3" modified="2021-06-02" version="1">MSDLVRVERKGRVTTVILNRPASRNAVNGPTAAALCAAFEQFDRDDAASVAVLWGAGGTFCAGADLKAFGTPEANSVHRTGPGPMGPSRMMLSKPVIAAVSGYAVAGGLELALWCDLRVAEEDAVFGVFCRRWGVPLIDGGTVRLPRLIGHSRAMDMILTGRGVPADEALAMGLANRVVPKGQARQAAEELAAQLAALPQQCLRSDRLSALHQWGLPESAALDLEFASIARVAGEALEGARRFAAGAGRHGAPAPRAEQGDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFD1</accession>
    <name>A0A7U8TFD1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="6">RNAP subunit beta</shortName>
            <ecNumber evidence="6 8">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpoB</name>
        <name evidence="16" type="ORF">TBLG_02807</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6 8">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="6 8"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900992.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFD1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA_pol_Rpb2_1" evidence="13">
        <location>
            <begin position="99"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_2" evidence="12">
        <location>
            <begin position="175"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_3" evidence="14">
        <location>
            <begin position="432"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_45" evidence="15">
        <location>
            <begin position="510"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_6" evidence="10">
        <location>
            <begin position="637"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_Rpb2_7" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EFD12223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1172" mass="129236" checksum="E263B698E126A943" modified="2021-06-02" version="1">MADSRQSKTAASPSPSRPQSSSNNSVPGAPNRVSFAKLREPLEVPGLLDVQTDSFEWLIGSPRWRESAAERGDVNPVGGLEEVLYELSPIEDFSGSMSLSFSDPRFDDVKAPVDECKDKDMTYAAPLFVTAEFINNNTGEIKSQTVFMGDFPMMTEKGTFIINGTERVVVSQLVRSPGVYFDETIDKSTDKTLHSVKVIPSRGAWLEFDVDKRDTVGVRIDRKRRQPVTVLLKALGWTSEQIVERFGFSEIMRSTLEKDNTVGTDEALLDIYRKLRPGEPPTKESAQTLLENLFFKEKRYDLARVGRYKVNKKLGLHVGEPITSSTLTEEDVVATIEYLVRLHEGQTTMTVPGGVEVPVETDDIDHFGNRRLRTVGELIQNQIRVGMSRMERVVRERMTTQDVEAITPQTLINIRPVVAAIKEFFGTSQLSQFMDQNNPLSGLTHKRRLSALGPGGLSRERAGLEVRDVHPSHYGRMCPIETPEGPNIGLIGSLSVYARVNPFGFIETPYRKVVDGVVSDEIVYLTADEEDRHVVAQANSPIDADGRFVEPRVLVRRKAGEVEYVPSSEVDYMDVSPRQMVSVATAMIPFLEHDDANRALMGANMQRQAVPLVRSEAPLVGTGMELRAAIDAGDVVVAEESGVIEEVSADYITVMHDNGTRRTYRMRKFARSNHGTCANQCPIVDAGDRVEAGQVIADGPCTDDGEMALGKNLLVAIMPWEGHNYEDAIILSNRLVEEDVLTSIHIEEHEIDARDTKLGAEEITRDIPNISDEVLADLDERGIVRIGAEVRDGDILVGKVTPKGETELTPEERLLRAIFGEKAREVRDTSLKVPHGESGKVIGIRVFSREDEDELPAGVNELVRVYVAQKRKISDGDKLAGRHGNKGVIGKILPVEDMPFLADGTPVDIILNTHGVPRRMNIGQILETHLGWCAHSGWKVDAAKGVPDWAARLPDELLEAQPNAIVSTPVFDGAQEAELQGLLSCTLPNRDGDVLVDADGKAMLFDGRSGEPFPYPVTVGYMYIMKLHHLVDDKIHARSTGPYSMITQQPLGGKAQFGGQRFGEMECWAMQAYGAAYTLQELLTIKSDDTVGRVKVYEAIVKGENIPEPGIPESFKVLLKELQSLCLNVEVLSSDGAAIELREGEDEDLERAAANLGINLSRNESASVEDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFF5</accession>
    <name>A0A7U8TFF5_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl-CoA hydratase 2</fullName>
            <ecNumber evidence="1">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Enoyl-CoA hydratase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02773</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="4.2.1.119" evidence="1"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003903106.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFF5"/>
    <dbReference type="GeneID" id="45424595"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="5">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="142" mass="14934" checksum="2E1C7C99BCC2D327" modified="2021-06-02" version="1">MALREFSSVKVGDQLPEKTYPLTRQDLVNYAGVSGDLNPIHWDDEIAKVVGLDTAIAHGMLTMGIGGGYVTSWVGDPGAVTEYNVRFTAVVPVPNDGKGAELVFNGRVKSVDPESKSVTIALTATTGGKKIFGRAIASAKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFF9</accession>
    <name>A0A7U8TFF9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rplE</name>
        <name evidence="9" type="ORF">TBLG_02860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403660.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFF9"/>
    <dbReference type="GeneID" id="45424681"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="7">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="8">
        <location>
            <begin position="91"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD12276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="187" mass="21019" checksum="CFC6FDB2718308BC" modified="2021-06-02" version="1">MTTAQKVQPRLKERYRSEIRDALRKQFGYGNVMQIPTVTKVVVNMGVGEAARDAKLINGAVNDLALITGQKPEVRRARKSIAQFKLREGMPVGVRVTLRGDRMWEFLDRLTSIALPRIRDFRGLSPKQFDGVGNYTFGLAEQAVFHEVDVDKIDRVRGMDINVVTSAATDDEGRALLRALGFPFKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFG9</accession>
    <name>A0A7U8TFG9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02875</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the UPF0677 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011610">
        <property type="entry name" value="CHP00027_methylltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00027">
        <property type="entry name" value="mthyl_TIGR00027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="318" mass="34949" checksum="245150B22E9D1BE7" modified="2021-06-02" version="1">MTQTGSARFEGDSWDLASSVGLTATMVAAARAVAGRAPGALVNDQFAEPLVRAVGVDFFVRMASGELDPDKLAEDEANGLRRFADAMAIRTHYFDNFFLDATRAGIRQAVILASGLDSRAYRLRWPAGTIVFEVDQPQVIDFKTTTLAGLGAAPTTDRRTVAVDLRDDWPTALQKAGFDNAQRTAWIAEGLLGYLSAEAQDRLLDQITAQSVPGSQFATEVLRDINRLNEEELRGRMRRLAERFRRHGLDLDMSGLVYFGDRTDARTYLADHGWRTASASTTDLLAEHGLPPIDGDDAPFGEVIYVSAELKQKHQDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFI9</accession>
    <name>A0A7U8TFI9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403841.1">
        <property type="nucleotide sequence ID" value="NZ_KK338668.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFI9"/>
    <dbReference type="GeneID" id="45424714"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="81" mass="8719" checksum="A02EDE63B68DAFEA" modified="2021-06-02" version="1">MRAIVGDCVIHIMPMGTGVELSKLADLALDIGRSVGCSAYENDFTLPDIPTQWRNQPLGWYTQGLAPYLPGLSDPKDAAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFK7</accession>
    <name>A0A7U8TFK7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02922</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403949.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007362">
        <property type="entry name" value="DUF429"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008306">
        <property type="entry name" value="UCP018008"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04250">
        <property type="entry name" value="DUF429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018008">
        <property type="entry name" value="UCP018008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="259" mass="28037" checksum="445132CC24515B9F" modified="2021-06-02" version="1">MYFVGVDLAWAGRNPTGVAAVDADGCLVGVGAARDDASVLAALRPYVVGDCLVAFDAPLVVANRTGQRPAEAALNRDFRQFEAGAYPANTEKPEFADVPRAARLARQLALDMDPLSSATRRAIEVYPHPATVALFRLPRALKYKAKPGRSVDLLKSELLRLMDGVEGLAQAGVRMQVAGQPDWVSLRRQVTVAQRKSDLRAAEDPIDAVVCAYVALYAQRRPADVTIYGDFTTGYIVTPSLPTDFRTAPDAGRRARARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFL6</accession>
    <name>A0A7U8TFL6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PE-PGRS family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02891</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000084">
        <property type="entry name" value="PE-PGRS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00934">
        <property type="entry name" value="PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031426759" evidence="1">
        <location>
            <begin position="31"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PE" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="157" mass="14362" checksum="F25CFD84052B48FC" modified="2021-06-02" version="1" fragment="single">MLAMPEVLGSAATDLAALGSVLGAADAAAAATTTGIVAAAQDEVSAAIAALFSAHGRAYQVASAQAAAVHAQFVEALSAGAGAYASAEAAGAAVLANPAQSVQQDLLAAVNAQSVALTGRPLIGNGANGAPGTGANGAPGGWLLGNGGAGGSAAAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFR5</accession>
    <name>A0A7U8TFR5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LytR/CpsA/Psr (LCP) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFR5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027381">
        <property type="entry name" value="LytR/CpsA/Psr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004474">
        <property type="entry name" value="LytR_CpsA_psr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13399">
        <property type="entry name" value="LytR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03816">
        <property type="entry name" value="LytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00350">
        <property type="entry name" value="lytR_cpsA_psr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LytR_cpsA_psr" evidence="3">
        <location>
            <begin position="254"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="LytR_C" evidence="4">
        <location>
            <begin position="557"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="652"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="684" mass="72865" checksum="708C6322421755EB" modified="2021-06-02" version="1">MSDGESAAPWARLSESAFPDGVDRWITVPPATWVAAQGPRDTQNVGCHATGAVSVADLIARLGPAFPDLPTHRHVAPEPEPSGRGPKVPDDADDQQDTEAIAIPAHSLEFLSELPDLRAANYPRADHARREPELPGKQLTGSARVRPLRIRRTSPAPAKPAPNSGRRPMVLAARSLAALFAALALALTGGAWQWSASKNSRLNMVSALDPHSGDIVNPSGQHGDENFLLVGMDSRAGANANIGAGDAEDAGGARSDTVMLVNIPASRERVVAVSFPRDLAITPIQCEAWNPETGKYGPIYDEKTGTMGPRLVYTETKLNSAFSFGGPKCLVKVIQKLSGLSINRFIAIDFVGFARMVEALGGVEVCSTTPLRDYELGTVLEHAGRQVIDGPTALNYVRARQVTTESNGDYGRIKRQQLFLSSLLRSMISTDTLFNLSRLNNVVNMFIGNSYVDNVKTKDLVELGRSLQHMAAGHVTFVTVPTGITDQNGDEPPRTSDMKALFTAIIDDDPLPLENDHNAQRLGNTPSTPPTTTKKAPQAGLTNEIQHQQVTTTSPKEVTVQVSNSTGQAGLATTATDQLKRNGFNVMAPDDYPSSLLATTVFFSPGNEQAAATVAAVFGQSKIERVTGIGQLVQVVLGQDFSAVRAPLPSGSTVSVQISRNSSSPPTKLPEDLTVTNAADTTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFV7</accession>
    <name>A0A7U8TFV7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase fadE10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03026</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898626.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFV7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="9">
        <location>
            <begin position="58"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="8">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="7">
        <location>
            <begin position="277"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="650" mass="70745" checksum="FECF934A3F01C0D1" modified="2021-06-02" version="1">MAQQTQVTEEQARALAEESRESGWDKPSFAKELFLGRFPLGLIHPFPKPSDAEEARTEAFLVKLREFLDTVDGSVIERAAQIPDEYVKGLAELGCFGLKIPSEYGGLNMSQVAYNRVLMMVTTVHSSLGALLSAHQSIGVPEPLKLAGTAEQKRRFLPRCAAGAISAFLLTEPDVGSDPARMASTATPIDDGQAYELEGVKLWTTNGVVADLLVVMARVPRSEGHRGGISAFVVEADSPGITVERRNKFMGLRGIENGVTRLHRVRVPKDNLIGREGDGLKIALTTLNAGRLSLPAIATGVAKQALKIAREWSVERVQWGKPVGQHEAVASKISFIAATNYALDAVVELSSQMADEGRNDIRIEAALAKLWSSEMACLVGDELLQIRGGRGYETAESLAARGERAVPVEQMVRDLRINRIFEGSSEIMRLLIAREAVDAHLTAAGDLANPKADLRQKAAAAAGASGFYAKWLPKLVFGEGQLPTTYREFGALATHLRFVERSSRKLARNTFYGMARWQASLEKKQGFLGRIVDIGAELFAISAACVRAEAQRTADPVEGEQAYELAEAFCQQATLRVEALFDALWSNTDSIDVRLANDVLEGRYTWLEQGILDQSEGTGPWIASWEPGPSTEANLARRFLTVSPSSEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFX5</accession>
    <name>A0A7U8TFX5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Resolvase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404760.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TFX5"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03769">
        <property type="entry name" value="SR_IS607_transposase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041718">
        <property type="entry name" value="IS607_transposase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="1">
        <location>
            <begin position="51"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="193" mass="21080" checksum="303F09466E9162A0" modified="2021-06-02" version="1">MNLADWAESVGVNRHTAYRWFREGTLPVPAERVGRLILVKTAASASAAAAGVVLYARVSSHDRRSDLDRQVARLTAWATERDLGVGQVVCEVGSGLNGKRPKLRRILSDPDARVIVVEHRDRLARFGVEHLEAALSAQGRRIVVADPGETTDDLVCDMIEVLTGMCARLYGRRGARNRAMRAVTEAKREPGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TFZ3</accession>
    <name>A0A7U8TFZ3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium chelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="170"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="459" mass="49561" checksum="A3DFB465B65BF51D" modified="2021-06-02" version="1">MSPSNLPRTVGELRAAGHRERGVKQEIRENLLTALADGDNVWPGILGFDDTVIPQVERALIAGHDFVLLGERGQGKTRLLRALAGLLDEWTPVIAGAELGEHPYTPITPESIRRAAQLGDDLPVAWKHRSERYTEKLATPDTSVADLVGDVDPIKVAEGRSLGDPEAIAYGLIPRAHRGIVAVNELPDLAERIQVSMLNVMEERDIQVRGYTLRLPLDVLVVASANPEDYTNRGRIITPIKDRFGAEIRTHYPLELEAEMGVIVQEAHLSAQVPDYLMQVLARFARYLRESRSIDQRSGVSARFAIAAAETVAAAARHRGAVLGETDPVARVVDLGTVIDVLRGKLEFESGEEGREQAVLEHLLRRATADTASRVLGGIDVGSLVTAVEGGSAVTTGERVSAKDVLAAVPGLPVVDRIARKLGAESEGERAAALELALEALYLAKRVDKVCGEGQTVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG55</accession>
    <name>A0A7U8TG55_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405368.1">
        <property type="nucleotide sequence ID" value="NZ_KK338665.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG55"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022171">
        <property type="entry name" value="PPE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12484">
        <property type="entry name" value="PPE-SVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-SVP" evidence="3">
        <location>
            <begin position="310"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="391" mass="38081" checksum="AFDF3EA4FB195C4F" modified="2021-06-02" version="1">MDFGALPPEINSARMYAGAGAGPMMAAGAAWNGLAAELGTTAASYESVITRLTTESWMGPASMAMVAAAQPYLAWLTYTAEAAAHAGSQAMASAAAYEAAYAMTVPPEVVAANRALLAALVATNVLGINTPAIMATEALYAEMWAQDALAMYGYAAASGAAGMLQPLSPPSQTTNPGGLAAQSAAVGSAAATAAVNQVSVADLISSLPNAVSGLASPVTSVLDSTGLSGIIADIDALLATPFVANIINSAVNTAAWYVNAAIPTAIFLANALNSGAPVAIAEGAIEAAEGAASAAAAGLADSVTPAGLGASLGEATLVGRLSVPAAWSTAAPATTAGATALEGSGWTVAAEEAGPVTGMMPGMASAAKGTGAYAGPRYGFKPTVMPKQVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TG82</accession>
    <name>A0A7U8TG82_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Enoyl-CoA hydratase echA8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could possibly oxidize fatty acids using specific components.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:16105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57318"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:20724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58521"/>
            <dbReference type="ChEBI" id="CHEBI:137480"/>
            <dbReference type="EC" id="4.2.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405712.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TG82"/>
    <dbReference type="GeneID" id="45425042"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="257" mass="27273" checksum="C8907716969540AA" modified="2021-06-02" version="1">MTYETILVERDQRVGIITLNRPQALNALNSQVMNEVTSAATELDDDPDIGAIIITGSAKAFAAGADIKEMADLTFADAFTADFFATWGKLAAVRTPTIAAVAGYALGGGCELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAERSGLVSRVVPADDLLTEARATATTISQMSASAARMAKEAVNRAFESSLSEGLLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGA6</accession>
    <name>A0A7U8TGA6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible peroxidase bpob</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="52"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="304" mass="32694" checksum="E9C4D568CA47C430" modified="2021-06-02" version="1" fragment="single">MTIWRVPSKVTSGPVSAVSSSPQAVAFSGARGITLVADEWNRGAAAADRPTILMLHGGGQNRFSWKNTGQILADEGHHVVALDTRGPGDSDRAPGADYAVETPTTDVLHVVEAIGRRVVVVEASMGGLTGILVAERAGPQTVNGLVLVDVVPRYEKEGNARIRDFMLGNIDGFGSLEEAADAVAEYLPHRDKPRSPEGLKRNLRLRDGRWHWHWDPAMMTAPGHDPQLRTENFERAAMGLTIPVLLIRGKLSDVVSSDGARDFLAKVPNAEFVESNCPTRGAPPPATTTTRSPTSWWTSSGDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGC7</accession>
    <name>A0A7U8TGC7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">WS_DGAT_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045017">
        <property type="term" value="P:glycerolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="PTHR31650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WS_DGAT_C" evidence="1">
        <location>
            <begin position="270"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="414" mass="44208" checksum="4C0CA5BBBDE15771" modified="2021-06-02" version="1">MAGHRMAAVDAQFYWMSAKVPNDQFLLYAFDGEPTDLERAVAQVYRRARGCPGLGMRVQDRGALAYPQWVPTPVQRDQLVCHDLADRSWQGCLAAVVGLAGKQLDMRRMPWRLHVFTPVHDVPGVSGLGTVAVMQFAHALGDGARASAMAAWLFGRPAAVPEIARSRAGFLPWRAAHAARAHLRLVRDTNAGLVAPGVGSRPPLSTNARPEGVRAVRTLLRRRSQLAGPTVTVTVLAAVSTGLLGLLGGDVDTLGAEVPMAKPGVPRSYNHFGNVVVGLYPRLEPDERVRRIATDLANARRRFEHPAMLSADRAFAAVPAALLRWGVSQFDAEVRPVRVAGNTVVSSVYRGAADLSFGDAPVVLTAGYPALSPAMGLTHGVHGIGDTVAISVHAAESAVSDIDAYMRLLDAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGG0</accession>
    <name>A0A7U8TGG0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyketide synthase associated protein papA3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensatn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="1">
        <location>
            <begin position="55"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="472" mass="51561" checksum="F376C44B4857CC77" modified="2021-06-02" version="1">MLRVGPLTIGTLDDWAPSTGSTVSWRPSAVAHTKASQAPISDVPVSYMQAQHIRGYCEQKAKGLDYSRLMVVSCQQPGQCDIRAANYVINAHLRRHDTYRSWFQYNGNGQIIRRTIQDPADIEFVPVHHGELTLPQIREIVQNTPDPLQWGCFRFGIVQGCDHFTFFASVDHVHVDAMIVGVTLMEFHLMYAAVVGGHAPLELPPAGSYDDFCRRQHTFSSTLTVESPQVRAWTKFAEGTNGSFPDFPLPLGDPSKPSDADIVTVMMLDEEQTAQFESVCTAAGARFIGGVLACCGLAEHELTGTTTYYGLTPRDTRRTPADAMTQGWFTGLIPITVPIAGSAFGDAARAAQTSFDSGVKLAEVPYDRVVELSSTLTMPRPNFPVVNFLDAGAAPLSVLLTAELTGTNIGVYSDGRYSYQLSIYVIRVEQGTAVAVMFPDNPIARESVARYLATLKSVFQRVAESGQQQNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGG3</accession>
    <name>A0A7U8TGG3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406243.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGG3"/>
    <dbReference type="GeneID" id="45425179"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="122" mass="13121" checksum="F8B6F09F168D87E9" modified="2021-06-02" version="1">MALVLVYLVVLVLVAIVLFAAASLLFGRGEQLPPLPRATTATTLPAFGVTRADVDAVKFTQVLRGYKTSEVDWVLERLGRELEALRSQLGAIHASSEDAEAESDASNPSRGETVVHYRSDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGH0</accession>
    <name>A0A7U8TGH0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03213</name>
        <name evidence="8" type="ORF">TBLG_03375</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGH0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01007">
        <property type="entry name" value="TRANSPOSASE_MUTATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="415" mass="45780" checksum="147DACFD43A17FF3" modified="2021-06-02" version="1">MTSSHLIDAEQLLADQLAQASPDLLRGLLSTFIAALMGAEADALCGAGYRERSDERSNQRNGYRHRDFDTRAATIDVAIPKLRQGSYFPDWLLQRRKRAERALTSVVATCYLLGVSTRRMERLVETLGVTKLSKSQVSIMAKELDEAVEAFRTRPLDAGPYTFLAADALVLKVREAGRVVGVHTLIATGVNAEGYREILGIQVTSAEDGAGWLAFFRDLVARGLSGVALVTSDAHAGLVAAIGATLPAAAWQRCRTHYAANLMAATPKPSWPWVRTLLHSIYDQPDAESVVAQYDRVLDALTDKLPAVAEHLDTARTDLLAFTAFPKQIWRQIWSNNPQERLNREVRRRTDVVGIFPDRASIIRLVGAVLAEQHDEWIEGRRYLGLEVLTRARAALTSTEEPAKQQTTNTPALTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGI2</accession>
    <name>A0A7U8TGI2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PPE family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the mycobacterial PPE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022171">
        <property type="entry name" value="PPE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000030">
        <property type="entry name" value="PPE_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038332">
        <property type="entry name" value="PPE_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00823">
        <property type="entry name" value="PPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12484">
        <property type="entry name" value="PPE-SVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPE" evidence="2">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="PPE-SVP" evidence="3">
        <location>
            <begin position="306"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="391" mass="39061" checksum="D9D901F165958ABA" modified="2021-06-02" version="1">MVDFGALPPEINSARMYAGPGSASLVAAAQMWDSVASDLFSAASAFQSVVWGLTVGSWIGSSAGLMVAAASPYVAWMSVTAGQAELTAAQVRVAAAAYETAYGLTVPPPVIAENRAELMILIATNLLGQNTPAIAVNEAEYGEMWAQDAAAMFGYAAATATATATLLPFEEAPEMTSAGGLLEQAAAVEEASDTAAANQLMNNVPQALQQLAQPTQGTTPSSKLGGLWKTVSPHLSPISNMVSMANNHMSMTNSGVSMTNTLSSMLKGFAPAAAAQAVQTAAQNGVQAMSSLGSSLGSSGLGGGVAANSGRAASVGSLSVPQAWAAANQAVTPAARALPLTSLTSAAERGPGQMLGGLPVGQMGARAGGGLSGVLRVPPRPYVMPHSPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGI7</accession>
    <name>A0A7U8TGI7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein lpqZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007210">
        <property type="entry name" value="ABC_Gly_betaine_transp_sub-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04069">
        <property type="entry name" value="OpuAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031280826" evidence="2">
        <location>
            <begin position="26"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="OpuAC" evidence="3">
        <location>
            <begin position="33"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="286" mass="29632" checksum="2937052CDD0BE242" modified="2021-06-02" version="1">MRITRILALLLAVLLAVSGVAGCSADTGDRHPELVVGSTPDSEAMLLAAIYVAALRSYGFAAHAETAADPVAKLDSGAFTVVPAFTGQMLQTLQPDASVRSDAQVYRAIVSALPEGIATGDYTTAAEDKPALVVTQSTAKAWGGGDLSELPSHCRGLLVGRVAGAHTPAAVGPCRLPAPREFRNDATMFAALRAGQLVAAWTTTADPDIPADLIMLTDGKPALIRAENIVPLYRRNALTERQLLAVNEVAGVLDTTALIGMRRQVAAGADPAAVAAGWLAEHPLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGJ5</accession>
    <name>A0A7U8TGJ5_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03402</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005182">
        <property type="entry name" value="DUF304"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014529">
        <property type="entry name" value="UCP026631"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03703">
        <property type="entry name" value="bPH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026631">
        <property type="entry name" value="UCP026631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="62"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="bPH_2" evidence="2">
        <location>
            <begin position="401"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="487" mass="52600" checksum="4C538C30F652E9E8" modified="2021-06-02" version="1">MTDRPHDWHRLSPRMLLVHPVHEMLRQLPVLIGSVVLGSATGNPVWPLAALGVTVVFGVLRWFFTTYRIDDENVSLRTGILSRRAVSVPRNRIRSVQTEARLLHRLLGLTVLRVGTGQEARGEAAFELDAVDSARVPRLRALLLAESLAPVEPTGRVLARWQSSWLRYAPLSFSGLVMIGAVIGLGYQTGLAVRLPESGFARSAVDAAQRAGVVLVVAVTVLLVVGVSALLAVLFSWLTYGNLLLRRGGSGQEGVLHLRHGLLRVREHTYDMRRLRGATLREPLLVRLLRGARLDAVMTGVHSEGQSSMLLPPCPFETATAVLTDLIDNTDAAAGPLRRHGPAAARRRWTRALLVPTLAGVALIAAAPILGVPGWAWTLWAVLTAGCAGLAVDRVRSLGHRVADGWLVARAGSLQRRRDCIACTGIIGWTVRQTLFQRRAGVATLVAATAAGRKGYQVLDVPAELAWSVAGAASPWVADSVWLRHGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGN7</accession>
    <name>A0A7U8TGN7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Homoserine kinase</fullName>
            <shortName evidence="11">HK</shortName>
            <shortName evidence="11">HSK</shortName>
            <ecNumber evidence="4 11">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">thrB</name>
        <name evidence="14" type="ORF">TBLG_03478</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>ATP + L-homoserine = ADP + H(+) + O-phospho-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="4 11"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406654.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGN7"/>
    <dbReference type="GeneID" id="45425270"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7 11" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031086078" description="Homoserine kinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="13">
        <location>
            <begin position="90"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EFD12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="316" mass="32346" checksum="6C1DA36925F8A427" modified="2021-06-02" version="1">MVTQALLPSGLVASAVVAASSANLGPGFDSVGLALSLYDEIIVETTDSGLTVTVDGEGGDQVPLGPEHLVVRAVQHGLQAAGVSAAGLAVRCRNAIPHSRGLGSSAAAVVGGLAAVNGLVVQTDSSPSSDAELIQLASEFEGHPDNAAAAVLGGAVVSWTDHSGDRPNYSAVSLRLHPDIRLFTAIPEQRSSTAETRVLLPAQVSHDDARFNVSRAALLVVALTERPDLLMAATEDLLHQPQRAAAMTASAEYLRLLRRHNVAAALSGAGPSLIALSTDSELPTDAVEFGAAKGFAVTELTVGEAVRWSPTVRVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGP4</accession>
    <name>A0A7U8TGP4_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpC</name>
        <name evidence="10" type="ORF">TBLG_03493</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cell membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406708.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGP4"/>
    <dbReference type="GeneID" id="45425285"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7 8" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 7 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_DE_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD12909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="121" mass="13135" checksum="26E8CC3A5B7BC8D0" modified="2021-06-02" version="1">MAELNVEIVAVDRNIWSGTAKFLFTRTTVGEIGILPRHIPLVAQLVDDAMVRVEREGEKDLRIAVDGGFLSVTEEGVSILAESAEFESEIDEAAAKQDSESDDPRIAARGRARLRAVGAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGS0</accession>
    <name>A0A7U8TGS0_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_03544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylyl cyclase class-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGS0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1159" mass="125056" checksum="45BFD3EFE1CAAE10" modified="2021-06-02" version="1">MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQIARTGHMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTRLNELAADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIACALELQLSTLAPMRPRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALGLIDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSRESIGVTGEVTWVVPSLSPANEAIQLFTERARLVQPNFEIVADNFDAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTGGARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEIDNLRAAFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDNHLVPAGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLSQIDYWQVVGIFISGQPIPLRAAAEQARELADSIGNRFVSRQCRLFACLAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIGDSAARTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAIEASEASWDLRNQHNVVTAHHELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TGS1</accession>
    <name>A0A7U8TGS1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003407157.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TGS1"/>
    <dbReference type="GeneID" id="45425343"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="261" mass="28308" checksum="3EA6FF4C22354308" modified="2021-06-02" version="1">MAETTEPPSDAGTSQADAMALAAEAEAAEAEALAAAARARARAARLKREALAMAPAEDENVPEEYADWEDAEDYDDYDDYEAADQEAARSASWRRRLRVRLPRLSTIAMAAAVVIICGFTGLSGYIVWQHHEATERQQRAAAFAAGAKQGVINMTSLDFNKAKEDVARVIDSSTGEFRDDFQQRAADFTKVVEQSKVVTEGTVNATAVESMNEHSAVVLVAATSRVTNSAGAKDEPRAWRLKVTVTEEGGQYKMSKVEFVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TH34</accession>
    <name>A0A7U8TH34_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein yrbE2B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="295" mass="30984" checksum="6D43330FF74C79CD" modified="2021-06-02" version="1">MVESSTASATAVLRARYPRTAASLDRYGGGTARRLERTGTFARFTRVSVVQIGWALRRYRRETLRLVAEIGMGTGAMAVVGGTVAIIGFVTLSGGSLIAIQGFASLGNIGVEAFTGFFAALANTRVAAPIVSGVALAATVGAGATAQLGAMRISEEIDALEVMGIKSISFLVSTRILGGLVVIMPLYALALDMAFTSGQVVTTVFYGQSNGTYEHYFRTFLRPEDVGWSVVEVVIIAVVVMITHCYYGYTASGGPVGVGQAVGRSMRFSLVSVVVVVLLAELALYGVDPNFNLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THA9</accession>
    <name>A0A7U8THA9_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusG</name>
        <name evidence="8" type="ORF">TBLG_02776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403288.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THA9"/>
    <dbReference type="GeneID" id="45424599"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD12192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="238" mass="25447" checksum="E083F9754E42144C" modified="2021-06-02" version="1">MTTFDGDTSAGEAVDLTEANAFQDAAAPAEEVDPAAALKAELRSKPGDWYVVHSYAGYENKVKANLETRVQNLDVGDYIFQVEVPTEEVTEIKNGQRKQVNRKVLPGYILVRMDLTDDSWAAVRNTPGVTGFVGATSRPSALALDDVVKFLLPRGSTRKAAKGAASTAAAAEAGGLERPVVEVDYEVGESVTVMDGPFATLPATISEVNAEQQKLKVLVSIFGRETPVELTFGQVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THD3</accession>
    <name>A0A7U8THD3_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="76" mass="8520" checksum="FB97EDA9DC270A5B" modified="2021-06-02" version="1">MHGGLIDSTASIWSYCPRPDSQPWQAATRAFSPEATKGAMRALWVSQREDLTADAKRVNLLGSMRRMWPKEVEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THJ8</accession>
    <name>A0A7U8THJ8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_02974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003404336.1">
        <property type="nucleotide sequence ID" value="NZ_KK338659.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THJ8"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD12391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="140" mass="15901" checksum="6481D2CB97E79452" modified="2021-06-02" version="1">MPAGMAGFRRWAQTNDPTAHAESLAIRAACTKLGTEHLVGTTLNVLAHPCPMCYGSLYYCSPDEVVFLTSRDAYEPHYVDDRRYFEPATFYDEFAKEWQDRRLPMRQEHRPDIRAGAVDVYRFRQEPNGGERSAIAAPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8THQ3</accession>
    <name>A0A7U8THQ3_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredox_DsbH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405750.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8THQ3"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="673" mass="71050" checksum="3B059D3A43AC3A3F" modified="2021-06-02" version="1">MSPANPSGTNTLALATSPYLRQHADNPVHWQQWTPQALAEAAARAVPILLSVGYAACHWCHVMAHESFDDDEVAAAMNAGFVCIKVDREERPDIDAVYMNATVALTGQGGWPMTCFLTPNGRPFFCGTYYPKAAFLQLLSAISETWRERRAEVEQASDHIAAELRSMASGLPGGGPEVAPELCDDAVAGVLREQDTAHGGFGGAPKFPPSALLEALMRHYERTRSPAALEAVARTGNAMARGGIYDQLGGGFARYSVDGAWVVPHFEKMLYDNALLLRAYAHWARRTGDPLARRVAAQTARFLLDELGSKAPADMFTSSLDADADGREGSTYVWTPVQLTEVLGGDDGRWAAEVFGVTEAGTFEHGTSVLQLPADPDDAARLDRVRAALLVARLARAQPARDDKVVTSWNGLAITALAEASVALDDPALAHAARRCATRLLDLHVVDGRLRRASLGGVVGDSAAILEDHAMLATGLLALYQLTSEGAWLTAATGLLDTAVAHFGDPQRPGRWFDTADDAERLMLRPSDPLDGATPSGASSIAEALLTAGHVVDGARAERYWQLAADTLRAHAVLLARAPRSAGHWLAVAEAVVRGPLQIAVACDLPRSSLLADARRLAPGGAIVVGGAAGSSALLVGRDRVAGADAAYVCRGRVCDLPVTSAAELATALGVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI02</accession>
    <name>A0A7U8TI02_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_03434</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406350.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI02"/>
    <dbReference type="GeneID" id="45425225"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="202" mass="22223" checksum="78934C8E146DC0BB" modified="2021-06-02" version="1">MAGTDWLSARRTELAADRILDAAERLFTQRDPASIGMNEIAKAAGCSRATLYRYFDSREALRTAYVHRETRRLGREIMVKIADVVEPAERLLVSITTTLRMVRDNPALAAWFTTTRPPIGGEMAGRSEVIAALAAAFLNSLGPDDPTTVERRARWVVRMLTSLLMFPGRDEADERAMIAEFVVPIVTPASAAARKAGHPGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI37</accession>
    <name>A0A7U8TI37_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003406722.1">
        <property type="nucleotide sequence ID" value="NZ_KK338644.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45425286"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019675">
        <property type="entry name" value="DUF2550"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10739">
        <property type="entry name" value="DUF2550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="147" mass="16594" checksum="A880FB972E48AE27" modified="2021-06-02" version="1">MSAPMIGMVVLVVVLGLAVLALSYRLWKLRQGGTAGIMRDIPAVGGHGWRHGVIRYRGGEAAFYRLSSLRLWPDRRLSRRGVEIISRRAPRGDEFDIMTDEIVVVELCDSTQDRRVGYEIALDRGALTAFLSWLESRPSPRARRRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI47</accession>
    <name>A0A7U8TI47_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="216" mass="23753" checksum="FFEE0A7C472689FC" modified="2021-06-02" version="1" fragment="single">MEIIPPRLKEPLYRLYELRLRQGLAASKSDLPRHIAVLCDGNRRWARSAGYDDVSYGYRMGAAKIAEMLRWCHEAGIELATVYLLSTENLQRDPDELAALIEIITDVVEEICAPANHWSVRTVGDLGLIGEEPARRLRGAVESTPEVASFHVNVAVGYGGRREIVDAVRALLSKELANGATAEELVDAVTVEGISENLYTSGQPDPDLVIRTSGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TI67</accession>
    <name>A0A7U8TI67_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898836.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TI67"/>
    <dbReference type="GeneID" id="45425332"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004111">
        <property type="entry name" value="Repressor_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02909">
        <property type="entry name" value="TetR_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="261" mass="28253" checksum="12B447D94D8B03AC" modified="2021-06-02" version="1">MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFADNPVLCDLILIRAALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDRLSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TIL7</accession>
    <name>A0A7U8TIL7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="83" mass="9064" checksum="EF3EA434AD3B34C2" modified="2021-06-02" version="1">MDLGFPDLLNRSTTADDWWRQVASQLAVPGITRGWATYRACRAMVASTQPCQFSPTSPRCNPTRIIVAASAPNAGAQHHRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR25</accession>
    <name>A0A7U8TR25_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415932.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025637">
        <property type="entry name" value="DUF4333"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14230">
        <property type="entry name" value="DUF4333"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031128426" evidence="1">
        <location>
            <begin position="27"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4333" evidence="2">
        <location>
            <begin position="23"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4333" evidence="2">
        <location>
            <begin position="106"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="182" mass="19272" checksum="DC20790DDAD005AC" modified="2021-06-02" version="1">MAHSIVRTLLASGAATALIAIPTACSFSIGTSHSHSVSKAEVARQITAKMTDAAGNKPESVTCPSDLPAEVGAELNCEMKIKDRTFNVNVTVTSVDGSDVKFDMVETVDKNQVANIISDKLFQRVGARPDSVTCPDNLKGVEGAKLRCRLTDGSKTYGISVIVTSVDAGDVNFDFKVDDHPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR32</accession>
    <name>A0A7U8TR32_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Protein NrdI</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nrdI</name>
        <name evidence="5" type="ORF">TBLG_03672</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Probably involved in ribonucleotide reductase function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NrdI family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415981.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR32"/>
    <dbReference type="GeneID" id="45427045"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00128">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020852">
        <property type="entry name" value="RNR_Ib_NrdI_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004465">
        <property type="entry name" value="RNR_NrdI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37297">
        <property type="entry name" value="PTHR37297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07972">
        <property type="entry name" value="Flavodoxin_NdrI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005087">
        <property type="entry name" value="NrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00333">
        <property type="entry name" value="nrdI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD14774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="150" mass="16491" checksum="EB8906ECBA275EB4" modified="2021-06-02" version="1">MDIAGRSLVYFSSVSENTHRFVQKLGIPATRIPLHGRIEVDEPYVLILPTYGGGRANPGLDAGGYVPKQVIAFLNNDHNRAQLRGVIAAGNTNFGAEFCYAGDVVSRKCSVPYLYRFELMGTEDDVAAVRTGLAEFWKEQTCHQPSLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR75</accession>
    <name>A0A7U8TR75_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PHB" evidence="1">
        <location>
            <begin position="14"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="253" mass="27830" checksum="CBAC97367BD42352" modified="2021-06-02" version="1">MQRRPCSLLGCFTIVGTRQFAIMTTFGRPTGVSLNNGFHGKWPWQMTHPMDGAVQIDKYVKEGNTDQRITVRLGNQSTALADVSIRWQLKQAAAPELFQQYKTFDNVRVNLIERNLSVALNEVFAGFNPLDPRNLDVSPLPSLAKRAADILRQDVGGQVDIFDVNVPTIQYDQSTEDKINQLNQQRAQTSIALEAQRTAEAQAKANEILSRSISDDPNVVVQNCITAAINKGISPLGCWPGSSALPTIAVPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR77</accession>
    <name>A0A7U8TR77_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">prfB</name>
        <name evidence="6" type="ORF">TBLG_03726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR77"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="378" mass="42125" checksum="6E8B10EFA45BEF4A" modified="2021-06-02" version="1">MPVTLAAVDPDRQADIAALDCTLTTVERVLDVEGLRSRIEKLEHEASDPHLWDDQTRAQRVTSELSHTQGELRRVEELRRRLDDLPVLYELAAEEAGAAAADAVAEADAELKSLRADIEATEVRTLLSGEYDEREALVTIRSGAGGVDAADWAEMLMRMYIRWAEQHKYPVEVFDTSYAEEAGIKSATFAVHAPFAYGTLSVEQGTHRLVRISPFDNQSRRQTSFAEVEVLPVVETTDHIDIPEGDVRVDVYRSSGPGGQSVNTTDSAVRLTHIPSGIVVTCQNEKSQLQNKIAAMRVLQAKLLERKRLEERAELDALKADGGSSWGNQMRSYVLHPYQMVKDLRTEYEVGNPAAVLDGDLDGFLEAGIRWRNRRNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TR97</accession>
    <name>A0A7U8TR97_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Usp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416373.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TR97"/>
    <dbReference type="GeneID" id="45427120"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="8"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD14857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="268" mass="28008" checksum="EE2CB4F9C9D602AE" modified="2021-06-02" version="1">MSDPRPARAVVVGIDGSRAATHAALWAVDEAVNRDIPLRLVYVIDPSQLSAAGEGGGQSAARAALHDASRKVEATGQPVKIETEVLCGRPLTKLMQESRSAAMLCVGSVGLDHVRGRRGSVAATLAGSALCPVAVIHPSPAEPATTSQVSAVVAEVDNGVVLRHAFEEARLRGVPLRAVAVHAAETPDDVEQGSRLAHVHLSRRLAHWTRLYPEVRVDRAIAGGSACRHLAANAKPGQLFVADSHSAHELCGAYQPGCAVLTVRSANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRE9</accession>
    <name>A0A7U8TRE9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Biotinylated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="71" mass="7320" checksum="91E752CC98E5EFBB" modified="2021-06-02" version="1">MAEDVRAEIVASVLEVVVNEGDQIDKGDIVVLLESMKMEIPVLAEAAGTVSKVAVSVGDVIQAGDLIAVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRG1</accession>
    <name>A0A7U8TRG1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate mutase gpm2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416878.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRG1"/>
    <dbReference type="GeneID" id="45427207"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD14947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="203" mass="21949" checksum="25293CE08DD88D55" modified="2021-06-02" version="1">MGVRNHRLLLLRHGETAWSTLGRHTGGTEVELTDTGRTQAELAGQLLGELELDDPIVICSPRRRTLDTAKLAGLTVNEVTGLLAEWDYGSYEGLTTPQIRESEPDWLVWTHGCPAGESVAQVNDRADSAVALALEHMSSRDVLFVSHGHFSRAVITRWVQLPLAEGSRFAMPTASIGICGFEHGVRQLAVLGLTGHPQPIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRG8</accession>
    <name>A0A7U8TRG8_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SecA DEAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_03878</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD14980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SECA_MOTOR_DEAD" evidence="9">
        <location>
            <begin position="15"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD14980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="187" mass="20603" checksum="6AA04EB86B318EFA" modified="2021-06-02" version="1" fragment="single">MGVALSKDSYTCGDIAVLSKLLRLGEGRMVKRLKKVADYVGTLSDDVEKLTDAELRAKTDEFKRRLADQKNPETLDDLLPEAFAVAREAAWRVLDQRPFDVQVMGAAALHLGNVAEMKTGEGKTLTCVLPAYLNALAGNGVHIVTVNDYLAKRDSEWMGRVHRFLGLQVGVILATMTPDERRVAYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRI4</accession>
    <name>A0A7U8TRI4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417115.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRI4"/>
    <dbReference type="GeneID" id="45427263"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009963">
        <property type="entry name" value="DUF1490"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07371">
        <property type="entry name" value="DUF1490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="93" mass="9750" checksum="1E35DD689EA5206A" modified="2021-06-02" version="1">MAIQVFLAKATTTVITGLAGVTAYEILKKAAAKAPLRQTAVSAAALGLRGTRKAEEAAESARLKVADVMAEARERIGEESPTPAISDLHDHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRJ0</accession>
    <name>A0A7U8TRJ0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SufE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03923</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SufE family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417152.1">
        <property type="nucleotide sequence ID" value="NZ_KK338634.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRJ0"/>
    <dbReference type="GeneID" id="45427280"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003808">
        <property type="entry name" value="Fe-S_metab-assoc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43597">
        <property type="entry name" value="PTHR43597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02657">
        <property type="entry name" value="SufE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SufE" evidence="2">
        <location>
            <begin position="16"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="143" mass="15395" checksum="C05E186CD3D2081D" modified="2021-06-02" version="1">MTAPASLPAPLAEVVSDFAEVQGQDKLRLLLEFANELPALPSHLAESAMEPVPECQSPLFLHVDASDPNRVRLHFSAPAEAPTTRGFASILAAGLDEQPAADILAVPEDFYTELGLAALISPLRLRGMSAMLARIKRRLREAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRN1</accession>
    <name>A0A7U8TRN1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030673983" evidence="2">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="96" mass="9315" checksum="737B3D8F003D3551" modified="2021-06-02" version="1" fragment="single">PSNPAAPGSVGNSWTPLAPVVEPPTPPTPASAAEPSMSAGVSESPMPNSTSTVAASPSTPSSKPEPGSIDPSLEPADEATNPAGQPAPETPVSPTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRU6</accession>
    <name>A0A7U8TRU6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Alternative RNA polymerase sigma factor sigJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">TBLG_04075</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">T46</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts transiently with the RNA polymerase catalytic core formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1 omega subunit) to form the RNA polymerase holoenzyme that can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417413.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRU6"/>
    <dbReference type="GeneID" id="45427330"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="7">
        <location>
            <begin position="6"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="8">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="SnoaL-like" evidence="9">
        <location>
            <begin position="175"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EFD15181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="312" mass="33561" checksum="87C1482953370A5C" modified="2021-06-02" version="1">MEVSEFEALRQHLMSVAYRLTGTVADAEDIVQEAWLRWDSQDTVIADPRAWLTTVVSRLGLDKLRSAAHRRETYTGTWLPEPVVTGLDATDPLAAVVAAEDARFAAMVVLERLRPDQRVAFVLHDGFAVPFAEVAEVLGTSEAAARQLASRARKAVTAQPALISGDPDPAHNEVVGRLMAAMAAGDLDTVVSLLHPDVTFTGDSNGKAPTAVRAVRGSDKVVRFILGLVQRYGPGLFGANQLALVNGELGAYTAGLPGVDGYRAMAPRITAITVRDGKVCALWDIANPDKFTGSPLKERRAQPTGRGRHHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRX2</accession>
    <name>A0A7U8TRX2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">dTDP-glucose-4,6-dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRX2"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031327896" evidence="1">
        <location>
            <begin position="32"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="39"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="364" mass="39501" checksum="75A90549EDA35D9E" modified="2021-06-02" version="1">MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEALVRTLRARGADVVSLDSRPSRYTNIVGCVSDRALLRDVMAGVEVVFHAAAHHKPQLAFLPRQAFLDTNIIGTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKASSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNIKANEYACRRVALEDAVDAHLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFARRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNWRPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFAPARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TRX6</accession>
    <name>A0A7U8TRX6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_04101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003418326.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TRX6"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023836">
        <property type="entry name" value="EccCa-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023837">
        <property type="entry name" value="EccCb-like_Actinobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03924">
        <property type="entry name" value="T7SS_EccC_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03925">
        <property type="entry name" value="T7SS_EccC_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="407"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="747"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="430"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="765"/>
            <end position="772"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="1035"/>
            <end position="1042"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD15207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1236" mass="131866" checksum="43FBB433E707FA2E" modified="2021-06-02" version="1">MNSGPACATADILVAPPPELRRSEPSSLLIRLLPVVMSVATVGVMVTVFLPGSPATRHPTFLAFPMMMLVSLVVTAVTGRGRRHVSGIHNDRVDYLGYLSVLRTSVTQTAAAQHVSLNWTHPDPATLWTLIGGPRMWERRPGAADFCRIRVGVGSAPLATRLVVGQLPPAQRADPVTRAALRCFLAAHATIADAPIAIPLRVGGPIAIDGDPTKVRGLLRAMICQLAVWHSPEELLIAGVVSDRNRAHWDWLKWLPHNQHPNACDALGPAPMVYSTLAEMQNALAATVLAHVVAIVDTAERGNGAITGVITIEVGARRDGAPPVVRCAGEVTALACPDQLEPQDALVCARRLAAHRVGHSGRTFIRGSGWAELVGIGDVAAFDPSTLWRNVNQHDRLRVPIGVTPDGTAVQLDIKEAAEQGMGPHGLCVGATGSGKSELLRTIALGMMARNSPEVLNLLLVDFKGGATFLDLAGAPHVAAVITNLAEEAPLVARMQDALAGEMSRRQQLLRMAGHLVSVTAYQRARQTGAQLPCLPILFIVVDEFSELLSQHPEFVDVFLAIGRVGRSLGMHLLLASQRLDEGRLRGLETHLSYRMCLKTWSASESRNVLGTQDAYQLPNTPGAGLLQTGTGELIRFQTAFVSGPLRRASPSAVHPVAPPSVRPFTTHAAAPVTAGPVGGTAEVPTPTVLHAVLDRLVGHGPAAHQVWLPPLDEPPMLGALLRDAEPAQAELAVPIGIVDRPFEQSRVPLTIDLSGAAGNVAVVGAPQTGKSTALRTLIMALAATHDAGRVQFYCLDFGGGALAQVDELPHVGAVAGRAQPQLASRMLAELESAVRFREAFFRDHGIDSVARYRQLRAKSAAESFADIFLVIDGWASLRQEFAALEESIVALAAQGLSFGVHVALSAARWAEIRPSLRDQIGSRIELRLADPADSELDRRQAQRVPVDRPGRGLSRDGMHMVIALPDLDGVALRRRSGDPVAPPIPLLPARVDYDSVVARAGDELGAHILLGLEERRGQPVAVDFGRHPHLLVLGDNECGKTAALRTLCREIVRTHTAARAQLLIVDFRHTLLDVIESEHMGGYVSSPAALGAKLSSLVDLLQARMPAPDVSQAQLRARSWWSGPDIYVVVDDYDLVAVSSGNPLMVLLEYLPHARDLGLHLVVARRSGGAARALFEPVLASLRDLGCRALLMSGRPDEGALFGSSRPMPLPPGRGILVTGAGDEQLVQVAWSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TS09</accession>
    <name>A0A7U8TS09_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase fadE27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="168" mass="18150" checksum="FF29D02C033AD42F" modified="2021-06-02" version="1">MDAARRVGGTDVAVWLGTLSTLSRTAFQLGVLERGLQMTAEYARTREQFDRPIGSFQAVGQRLADGYIDVKGLRLTLTQAAWRVAEDSLASRECPQPADIDVATAGFWAAEAGHRVAHTIVHVHGGVGVDTDHPVHRYFLAAKQTEFALGGATGQLRRIGRELAETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TT75</accession>
    <name>A0A7U8TT75_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD14852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="87" mass="10069" checksum="FFF0A6FFEAF37B51" modified="2021-06-02" version="1">MRGGFRGGRPQRCRGLERDRQGSRPGADDRRGVREAERAQLLPWTATLKRHCVRVIPWEITGRHFRFGPEPDRSQTFACEASSHNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTT2</accession>
    <name>A0A7U8TTT2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="2">HAT</shortName>
            <ecNumber evidence="2">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Homoserine transacetylase</fullName>
            <shortName evidence="2">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metXA</name>
        <name evidence="5" type="ORF">TBLG_04061</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="2"/>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417458.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTT2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="52"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2 3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="active site" evidence="2 3">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD15167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="379" mass="39769" checksum="6F3506E4CC094D43" modified="2021-06-02" version="1">MTISDVPTQTLPAEGEIGLIDVGSLQLESGAVIDDVCIAVQRWGKLSPARDNVVVVLHALTGDSHITGPAGPGHPTPGWWDGVAGPGAPIDTTRWCAVATNVLGGCRGSTGPSSLARDGKPWGSRFPLISIRDQVQADVAALAALGITEVAAVVGGSMGGARALEWVVGYPDRVRAGLLLAVGARATADQIGTQTTQIAAIKADPDWQSGDYHETGRAPDAGLRLARRFAHLTYRGEIELDTRFANHNQGNEDPTAGGRYAVQSYLEHQGDKLLSRFDAGSYVILTEALNSHDVGRGRGGVSAALRACPVPVVVGGITSDRLYPLRLQQELADLLPGCAGLRVVESVYGHDGFLVETEAVGELIRQTLGLADREGACRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TTX7</accession>
    <name>A0A7U8TTX7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxy-2-oxovalerate aldolase mhpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003900067.1">
        <property type="nucleotide sequence ID" value="NZ_KK338657.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TTX7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="336" mass="36297" checksum="511C3CE6D4BEBEE3" modified="2021-06-02" version="1">MLMTATHREPIVLDTTVRDGSYAVNFQYTDDDVRRIVGDLDAAGIPYIEIGHGVTIGAAAAQGPAAHTDEEYFRAARSVVRNARLGAVIVPALARIETVDLAGDYLDFLRICVIATEFELVMPFVERAQSKGLEVSIQLVKSHLFEPDVLAAAGKRARDVGVRIVYVVDTTGTFLPEDARRYVEALRGASDVSVGFHGHNNLAMAVANTLEAFDAGADFLDGTLMGFGRGAGNCQIECLVAALQRRGHLAAVDLDRIFDAARSDMLGRSPQSYGIDPWEISFGFHGLDSLQVEHLRAAAQQAGLSVSHVIRQTAKSHAGQWLSPQDIDRVVVGMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TU35</accession>
    <name>A0A7U8TU35_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_04016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8TU35"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD15118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="102" mass="11031" checksum="644D4A89C5C2F79D" modified="2021-06-02" version="1">MTPTACATVSTMTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEPLDLDAGVELPSVTLARLREHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8TU75</accession>
    <name>A0A7U8TU75_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sugar-transport membrane protein sugI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">TBLG_04072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">T46</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417416.1">
        <property type="nucleotide sequence ID" value="NZ_KK338662.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45427333"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="54"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EFD15178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="502" mass="53059" checksum="0B3BB591CF47196D" modified="2021-06-02" version="1">MTTLWQPHRNDYSPIPGRGVHARRGARRPRPRGGRAERPGTGQLTRSGRRALLVGLTAASVGVLYGYDLSAIAGALLSLSEEFELTTREQELLTTTAVLGQIAGALGGGILANAIGRKKSVVLIVAGYAVFALLGATSVSVPMLVVARLLLGVTIGLSVVVVPVYVAESAPAAVRGSLVTAYQLATLSGIVVGYLVGYLLAGSHGWRAMFGLAAAPATLLLPLLWRMPDTARWYLLKGRIADARSALRRIQPEADIDAELADMAAAVDERGGGIGEMVRRPYLRATLFVIALGFLVQITGINAIIYYSPRLFAAMGFAGYFAMLALPAMVQVAGLAAVCASLFLVDRLGRRPILLSGIATMITADAVLITVFANDSDGGTGLVLGFAGVLLFIIGFNFGFGSLVWVYAAESFPSRLRSMGSSLMLTSTLTANAIVAAFSLTMLRVLGGAGVFAVFGTFAVVAFVVVYRFAPETKGRKLEEIRHFWENGGRWPAERSPAADEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y204</accession>
    <name>A0A7U8Y204_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PGA_cap domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_02703</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGA_cap" evidence="2">
        <location>
            <begin position="9"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="380" mass="41547" checksum="5197A2C71A981EF6" modified="2021-06-02" version="1">MAGNPDVVTVLLGGDVMLGRGVDQILPHPGKPQLRERYMRDATGYVRLAERVNGRIPLPVDWRWPWGEALAVLENTATDVCLINLETTITADGEFADRKPVCYRMHPDNVPALTALRPHVCALANNHILDFGYQGLTDTVAALAGAGIQSVGAGADLLAARRSALVTVGHERRVIVGSVAAESSGVPESWAARRDRPGVWLIRDPAQRDVADDVAAQVLADKRPGDIAIVSMHWGSNWGYATAPGDVAFAHRLIDAGIDMVHGHSSHHPRPIEIYRGKPILYGCGDVVDDYEGIGGHESFRSELRLLYLTVTDPASGNLISLQMLPLRVSRMRLQRASQTDTEWLRNTIERISRRFGIRVVTRPDNLLEVVPAANLTSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2I1</accession>
    <name>A0A7U8Y2I1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fructose-1,6-bisphosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">TBLG_03273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the FBPase class 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01516">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004464">
        <property type="entry name" value="FBPase_class-2/SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30447">
        <property type="entry name" value="PTHR30447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03320">
        <property type="entry name" value="FBPase_glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004532">
        <property type="entry name" value="GlpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00330">
        <property type="entry name" value="glpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="181"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR004532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004532-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EFD12689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="328" mass="34569" checksum="A04CA72CFB3753A0" modified="2021-06-02" version="1">MELVRVTEAGAMAAGRWVGRGDKEGGDGAAVDAMRELVNSVSMRGVVVIGEGEKDHAPMLYNGEEVGNGDGPECDFAVDPIDGTTLMSKGMTNAISVLAVADRGTMFDPSAVFYMNKIAVGPDAAHVLDITAPISENIRAVAKVKDLSVRDMTVCTLDRPRHAQLIHDVRATGARIRLITDGDVAGAISACRPHSGTDLLAGIGGTPEGIIAAAAIRCMGGAIQAQLAPRDDAERRKALEAGYDLNQVLTTEDLVSGENVFFCATGVTDGDLLKGVRYYPGGCTTHSIVMRSKSGTVRMIEAYHRLSKLNEYSAIDFTGDSSAVYPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2I7</accession>
    <name>A0A7U8Y2I7_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dehydrogenase/reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_02916</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403924.1">
        <property type="nucleotide sequence ID" value="NZ_KK338658.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2I7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="4">
        <location>
            <begin position="10"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="5">
        <location>
            <begin position="170"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD12332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="295" mass="30446" checksum="7A9E7FBFAD0E95B8" modified="2021-06-02" version="1">MTAHPETPRLGYIGLGNQGAPMAKRLLDWPGGLTVFDVRVEAMAPFVEGGATAAASVSDVAEADIISITVFDDAQVSSVITADNGLATHAKPGTIVAIHSTIADTTAVDLAEKLKPQGIHIVDAPVSGGAAAAAKGELAVMVGADDEAFQRIKEPFSRWASLLIHAGEPGAGTRMKLARNMLTFVSYAAAAEAQRLAEACGLDLVALGKVVRHSDSFTGGAGAIMFRNTTAPMEPADPLRPLLEHTRGLGEKDLSLALALGEVVSVDLPLAQLALQRLAAGLGVPHPDTEPAKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2K4</accession>
    <name>A0A7U8Y2K4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_02738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021027">
        <property type="entry name" value="Transposase_put_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12323">
        <property type="entry name" value="HTH_OrfB_IS605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_OrfB_IS605" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="238" mass="26962" checksum="19C96B203E7BCB08" modified="2021-06-02" version="1">MCKAFRFTLDPTAEQAHALARHFGARRKAYNLDRRAAESRYSKRWRATGAQTAKPSLRVLRKRWNTVKDEVCVNAETGTVWWPECSKEAYADGIAGAVDAYWNWQQRRAGKRDGKRMGFPRFKKKGRDADRVSFTTGAMRVEPDRRHLTLPVIGCVRTHENTRRIERLIAKDRARVLAITVRRNGTRLDASVRVLVQRPQQPNVELPESRIGVDVGVRRLATVATADGACCPVLVPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2Q1</accession>
    <name>A0A7U8Y2Q1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein lprD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898833.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2Q1"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="126" mass="14273" checksum="EFE23311D1FDC205" modified="2021-06-02" version="1">MSTTRRRRPALIALVIIATCGCLALGWWQWTRFQSTSGTFQNLGYALQWPLFAWFCVYAYRNFVRYEETPPQPPTGGAAAEIPAGLLPERPKPAQQPPDDPVLREYNAYLAELAKDDARKQNRTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2S1</accession>
    <name>A0A7U8Y2S1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="14">DHBP synthase</shortName>
            <ecNumber evidence="14">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ribB</name>
        <name evidence="17" type="ORF">TBLG_03603</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 14">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 14">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the N-terminal section; belongs to the DHBP synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="14"/>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00180">
        <property type="entry name" value="RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="SSF142695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP_cyclohydro2" evidence="16">
        <location>
            <begin position="211"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="14">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="14">
        <location>
            <begin position="141"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="339"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="14">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="site" description="Essential for catalytic activity" evidence="14">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EFD13019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="397" mass="42894" checksum="84C65159BF906AA8" modified="2021-06-02" version="1">MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGLALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLSLTTCRRKGLRDRRTDPGRSWGTFDEAADQQPGQAGGTGWIRIAHHRARAAAGAGQRGEHPLPDDQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2U7</accession>
    <name>A0A7U8Y2U7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="8">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">metG</name>
        <name evidence="13" type="ORF">TBLG_03171</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="8"/>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405183.1">
        <property type="nucleotide sequence ID" value="NZ_KK338655.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y2U7"/>
    <dbReference type="GeneID" id="45424979"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="11">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="11">
        <location>
            <begin position="150"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="12">
        <location>
            <begin position="374"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="299"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD12587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="519" mass="57994" checksum="FC019248902EE6E2" modified="2021-06-02" version="1">MKPYYVTTAIAYPNAAPHVGHAYEYIATDAIARFKRLDGYDVRFLTGTDEHGLKVAQAAAAAGVPTAALARRNSDVFQRMQEALNISFDRFIRTTDADHHEASKELWRRMSAAGDIYLDNYSGWYSVRDERFFVESETQLVDGTRLTVETGTPVTWTEEQTYFFRLSAYTDKLLAHYHANPDFIAPETRRNEVISFVSGGLDDLSISRTSFDWGVQVPEHPDHVMYVWVDALTNYLTGAGFPDTDSELFRRYWPADLHMIGKDIIRFHAVYWPAFLMSAGIELPRRIFAHGFLHNRGEKMSKSVGNIVDPVALAEALGVDQVRYFLLREVPFGQDGSYSDEAIVTRINTDLANELGNLAQRSLSMVAKNLDGRVPNPGEFADADAALLATADGLLERVRGHFDAQAMHLALEAIWLMLGDANKYFSVQQPWVLRKSESEADQARFRTTLYVTCEVVRIAALLIQPVMPESAGKILDLLGQAPNQRSFAAVGVRLTPGTALPPPTGVFPRYQPPQPPEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y2V2</accession>
    <name>A0A7U8Y2V2_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FMN_red domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="19"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="245" mass="26886" checksum="E68DB6A87889EEEC" modified="2021-06-02" version="1">MTTTSDQNAAAPPRFDGLRALFINATLKRSPELSHTGGLIERSSGIMREHGVQVDTLRAVDHDIATGVWPDMTEHGWATDEWPALYRRVLDAHILVLCGPIWLGDNSSVMKRVIERLYACSSLLNEDGQYAYYGRAGGCLITGNEDGVKHCAMNVLYSLQHLGYTIPPQADAGWIGEAGPGPSYLDPGSGGPENDFTNRNTTFMTFNLMHIAQMLRVAGGIPAYGNQRTKWDAGCRPDFANPDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y476</accession>
    <name>A0A7U8Y476_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_02887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403820.1">
        <property type="nucleotide sequence ID" value="NZ_KK338667.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424708"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="185" mass="20143" checksum="D80EE7B5C3E42033" modified="2021-06-02" version="1">MTRQQLAHLLRRACAVVGDVDVLVLGSQSILGSFDENELPPQATASQEADIAFVNDPARDKADHVDVAIGEMSDFHRSNGVYAEGVHIDTAILPNGWRDRLVSWTVESSRPAKPRFLEPHDLAVAKLAAGREKDKAFVAALIRSGLLDVGVIQARVLLLPEETDPRIGQRIAAWLNYYGAGNHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4A4</accession>
    <name>A0A7U8Y4A4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MCE-family protein mce2D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">TBLG_02724</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003403112.1">
        <property type="nucleotide sequence ID" value="NZ_KK338632.1"/>
    </dbReference>
    <dbReference type="GeneID" id="45424560"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005693">
        <property type="entry name" value="Mce"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024516">
        <property type="entry name" value="Mce_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11887">
        <property type="entry name" value="Mce4_CUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00996">
        <property type="entry name" value="Mtu_fam_mce"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5030961040" evidence="2">
        <location>
            <begin position="36"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="3">
        <location>
            <begin position="46"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Mce4_CUP1" evidence="4">
        <location>
            <begin position="128"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EFD12140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="508" mass="54540" checksum="0D6C04B48ACCF682" modified="2021-06-02" version="1">MSTIFDIRSLRLPKLSAKVVVVGGLVVVLAVVAAAAGARLYRKLTTTTVVAYFSEALALYPGDKVQIMGVRVGSIDKIEPAGDKMRVTLHYSNKYQVPATATASILNPSLVASRTIQLSPPYTGGPVLQDGAVIPIERTQVPVEWDQLRDSINGILRQLGPTERQPKGPFGDLIESAADNLAGKGRQLNETLNSLSQALTALNEGRGDFVAITRSLALFVSALYQNDQQFVALNENLAEFTDWFTKSDHDLADTVERIDDVLGTVRKFVSDNRSVLAADVNNLADATTTLVQPEPRDGLETALHVLPTYASNFNNLYYPLHSSLVGQFVFPNFANPIQLICSAIQAGSRLGYQESAELCAQYLAPVLDALKFNYLPFGSNPFSSAATLPKEVAYSEERLRPPPGYKDTTVPGIFSRDTPFSHGNHEPGWVVAPGMQGMQVQPFTANMLTPESLAELLGGPDIAPPPPGTNLPGPPNAYDESNPLPPPWYPQPASLPAAGATGQPGPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4I1</accession>
    <name>A0A7U8Y4I1_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">TBLG_03202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EFD12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="112" mass="12996" checksum="E6A250E176F8135B" modified="2021-06-02" version="1">MIPGRMVLNWEDGLNALVAEGIEAIVFRTLGDQCWLWESLLPDEVRRLPEELARVDALLDDPAFFAPFVPFFDPRRGRPSTPMEVYLQLMFVKFRYRLGYESLCREVADSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4N6</accession>
    <name>A0A7U8Y4N6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003901049.1">
        <property type="nucleotide sequence ID" value="NZ_KK338639.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045931">
        <property type="entry name" value="DUF6350"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19877">
        <property type="entry name" value="DUF6350"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="455" mass="46089" checksum="A8BF6E7A6BA48E42" modified="2021-06-02" version="1">MNRVSASADDRAAGARPARDLVRVAFGPGVVALGIIAAVTLLQLLIANSDMTGAWGAIASMWLGVHLVPISIGGRALGVMPLLPVLLMVWATARSTARATSPQSSGLVVRWVVASALGGPLLMAAIALAVIHDASSVVTELQTPSALRAFTSVLVVHSVGAATGVWSRVGRRALAATALPDWLHDSMRAAAAGVLALLGLSGVVTAGSLVVHWATMQELYGITDSIFGQFSLTVLSVLYAPNVIVGTSAIAVGSSAHIGFATFSSFAVLGGDIPALPILAAAPTPPLGPAWVALLIVGASSGVAVGQQCARRALPFVAAMAKLLVAAVAGALVMAVLGYGGGGRLGNFGDVGVDEGALVLGVLFWFTFVGWVTVVIAGGISRRPKRLRPAPPVELDADESSPPVDMFDGAASEQPPASVAEDVPPSHDDIANGLKAPTADDEALPLSDEPPPRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4Q6</accession>
    <name>A0A7U8Y4Q6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">TBLG_03427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EFD12843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="262" mass="27601" checksum="EC43F9C8D42C77BD" modified="2021-06-02" version="1">MSARRIRSWKRFDNRSANAAEPDPQLAGTGGRPKVSTRALAQVIERSSRIQGPAAQAYVARLRRAHPGASPAKIVAKLEKRFLSVVTASGAAVGAAATLPGIGTLAAWFAAAGEVVVFLEATALFVLALASVHAIPLDHRERRRALVLAVLVGDNTTAVADLLGPGRTSGGWVSETMASLPLPAISSLNSRMLKYVVKRFALKRGALMFGKLVPMGIGAIIGAIGNRLVGKKLVRNARSAFGTPPARWPVTLHVLPTVWDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4S2</accession>
    <name>A0A7U8Y4S2_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein lpqV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663490">
        <property type="protein sequence ID" value="EFD12650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405645.1">
        <property type="nucleotide sequence ID" value="NZ_KK338663.1"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020377">
        <property type="entry name" value="Uncharacterised_LpqV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17301">
        <property type="entry name" value="LpqV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5031237865" evidence="1">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="139" mass="14110" checksum="334F20C6EC237FAB" modified="2021-06-02" version="1">MRPSRYAPLLCAMVLALAWLSAVAGCSRGGSSKAGRSSSVAGTLPAGVVGVSPAGVTTRVDAPAESTEEEYYQACHAARLWMDAQPGSGESLIEPYLAVVQASPSGVAGSWHIRWAALTPARQAAVIVAARAAANAECG</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4T6</accession>
    <name>A0A7U8Y4T6_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cholesterol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405840.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4T6"/>
    <dbReference type="GeneID" id="45425080"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003854">
        <property type="term" value="F:3-beta-hydroxy-delta5-steroid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3Beta_HSD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="370" mass="40742" checksum="B2A93EC32AFEEA0B" modified="2021-06-02" version="1">MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPSLLPAHPQLEVLQGDITDADVCAAAVDGIDTIFHTAAIIELMGGASVTDEYRQRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGDETLPYTDRFNDLYTETKVVAERFVLAQNGVDGMLTCAIRPSGIWGNGDQTMFRKLFESVLKGHVKVLVGRKSARLDNSYVHNLIHGFILAAAHLVPDGTAPGQAYFINDAEPINMFEFARPVLEACGQRWPKMRISGPAVRWVMTGWQRLHFRFGFPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPLFTTQQALTECLPYYVSLFEQMKNEARAEKTAATVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y4U4</accession>
    <name>A0A7U8Y4U4_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD12725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003405922.1">
        <property type="nucleotide sequence ID" value="NZ_KK338654.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y4U4"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_C" evidence="1">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD12725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="80" mass="8801" checksum="F6F56F987255B749" modified="2021-06-02" version="1">MQLGNQNTMRFAGRPQRFRQSAYPLFNPNSAIALGHPFGGSGARLMTTVLHHMPDKGIRYGLQTMCEGRGQANATIVELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y530</accession>
    <name>A0A7U8Y530_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein TBLG_03609</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_03609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="GG663491">
        <property type="protein sequence ID" value="EFD13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003898873.1">
        <property type="nucleotide sequence ID" value="NZ_KK338642.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y530"/>
    <dbReference type="GeneID" id="45425399"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="301" mass="32912" checksum="FB546C303B51C01A" modified="2021-06-02" version="1">MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFMEASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLRDSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMGLLRSDQQLSVRALHRDLGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7C0</accession>
    <name>A0A7U8Y7C0_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="7">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mnmA</name>
        <name evidence="8" type="ORF">TBLG_03643</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">T46</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="7"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003415909.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7C0"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Interaction with tRNA" evidence="7">
        <location>
            <begin position="143"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="7">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="7">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EFD14745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="367" mass="38120" checksum="043ECC2D5D690C79" modified="2021-06-02" version="1">MKVLAAMSGGVDSSVAAARMVDAGHEVVGVHMALSTAPGTLRTGSRGCCSKEDAADARRVADVLGIPFYVWDFAEKFKEDVINDFVSSYARGETPNPCVRCNQQIKFAALSARAVALGFDTVATGHYARLSGGRLRRAVDRDKDQSYVLAVLTAQQLRHAAFPIGDTPKRQIRAEAARRGLAVANKPDSHDICFIPSGNTKAFLGERIGVRRGVVVDADGVVLASHDGVHGFTIGQRRGLGIAGPGPNGRPRYVTAIDADTATVHVGDVTDLDVQTLTGRAPVFTAGAAPSGPVDCVVQVRAHGETVSAVAELIGDALFVQLHAPLRGVARGQTLVLYRPDPAGDEVLGSATIAGASGLSTGGNPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-05-25" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y7Y7</accession>
    <name>A0A7U8Y7Y7_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">TBLG_03706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">T46</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003416075.1">
        <property type="nucleotide sequence ID" value="NZ_KK338652.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y7Y7"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023921">
        <property type="entry name" value="ADH_Zn_actinomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03989">
        <property type="entry name" value="Rxyl_3153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="5">
        <location>
            <begin position="12"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EFD14808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="368" mass="38342" checksum="A03FCB6F3C8003AF" modified="2021-06-02" version="1">MKTTAAVLFEAGKPFELMELDLDGPGPGEVLVKYTAAGLCHSDLHLTDGDLPPRFPIVGGHEGSGVIEEVGAGVTRVKPGDHVVCSFIPNCGTCRYCCTGRQNLCDMGATILEGCMPDGSFRFHSQGTDFGAMCMLGTFAERATVSQHSVVKVDDWLPLETAVLVGCGVPSGWGTAVNAGNLRAGDTAVIYGVGGLGINAVQGATAAGCKYVVVVDPVAFKRETALKFGATHAFADAASAAAKVDELTWGQGADAALILVGTVDDEVVSAATAVIGKGGTVVITGLADPAKLTVHVSGTDLTLHEKTIKGSLFGSCNPQYDIVRLLRLYDAGQLMLDELVTTTYNLEQVNQGYQDLRDGKNIRGVIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8Y840</accession>
    <name>A0A7U8Y840_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside hydrolase iunH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">TBLG_04008</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417946.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8Y840"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901564">
        <property type="term" value="P:organonitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="PTHR12304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="SSF53590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IU_nuc_hydro" evidence="3">
        <location>
            <begin position="4"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EFD15110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="308" mass="32970" checksum="F8F8A15A56B71F66" modified="2021-06-02" version="1">MSVVFADVDTGIDDALAVIYLLASPDADLVGIASTGGNIAVGQVCANNLSLLELCGAADIPVSKGADEPLGGRWPDHPKFHGPKGIGYAELPASNRRLTDYDATTAWIAAAHSHAGDLIGLVTGPLTNLALALRAEPALPRLLRRLVIMGGMFDGQPITEWNIRVDPEAASEVFTAWAGQRQLPIVCGLDLTRRVAMTPDILARLASVCGSSPVMRVIEDALRFYFESHEARGHGYLAYMHDPLAAAVAMDPELLTTRTATVDVDPTGATVTDWSGKRNPNARIGMSVDPAVFFDRFVERIGRFARRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="5" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YA45</accession>
    <name>A0A7U8YA45_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">TBLG_03829</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">T46</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="GG663493">
        <property type="protein sequence ID" value="EFD14931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038726">
        <property type="entry name" value="PDDEXK_AddAB-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12705">
        <property type="entry name" value="PDDEXK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="11">
        <location>
            <begin position="22"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="12">
        <location>
            <begin position="357"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EFD14931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="1101" mass="116717" checksum="891FF3BD3087A01A" modified="2021-06-02" version="1">MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVIAGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRLARLAGIGLGCGDPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDTRLLSETELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLGEHLVDTRALRDTHVELERLVHALPAGRYQRDRGPSQWLLRMLATQTQRAELVPLLDALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLDEYQDTGHAQRVVLSSLFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRALRPRPDAPPGAVRCALLPDVQAEREWIADHLRMRYQRAEADGVKPPTAAVLVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPTAGAAAMRVLTGPRWRLGARDLAALWRRALTLSGESPSTASPESIAMAASVDADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRLGHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAERASARSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVHAAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAELPPLLRGDRASAGAHGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDTLLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPAGDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDIDHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDPVGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADREVGDPEELAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAVFVDPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVYRLAWAALRGCPTSSVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-01-19" version="3" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAB1</accession>
    <name>A0A7U8YAB1_MYCTX</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663494">
        <property type="protein sequence ID" value="EFD15139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_003417776.1">
        <property type="nucleotide sequence ID" value="NZ_KK338647.1"/>
    </dbReference>
    <dbReference type="SMR" id="A0A7U8YAB1"/>
    <dbReference type="GeneID" id="45427363"/>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="11"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="130" mass="13440" checksum="7BE358D961B3AAC1" modified="2021-06-02" version="1">MKARLPDSPLDWLVSKFAREVPGVAHALLVSVDGLPVAASEHLPRERADQLAAVTSGLASLAGGAAQLFDGGQVLQSVVEMQNGYLLLMQVGDGSALAALAATGCDIGQIGYEMAILVERVGGVVQSCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2021-06-02" modified="2022-08-03" version="4" xmlns="http://uniprot.org/uniprot">
    <accession>A0A7U8YAF9</accession>
    <name>A0A7U8YAF9_MYCTX</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase fadE27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">TBLG_04155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Mycobacterium tuberculosis T46</name>
        <dbReference type="NCBI Taxonomy" id="611302"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Actinobacteria</taxon>
            <taxon>Corynebacteriales</taxon>
            <taxon>Mycobacteriaceae</taxon>
            <taxon>Mycobacterium</taxon>
            <taxon>Mycobacterium tuberculosis complex</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2009-03" db="EMBL/GenBank/DDBJ databases">
            <title>The Genome Sequence of Mycobacterium tuberculosis strain T46.</title>
            <authorList>
                <consortium name="The Broad Institute Genome Sequencing Platform"/>
                <person name="Small P."/>
                <person name="Gagneaux S."/>
                <person name="Hopewell P."/>
                <person name="Young S.K."/>
                <person name="Kodira C.D."/>
                <person name="Zeng Q."/>
                <person name="Koehrsen M."/>
                <person name="Alvarado L."/>
                <person name="Berlin A."/>
                <person name="Borenstein D."/>
                <person name="Chen Z."/>
                <person name="Engels R."/>
                <person name="Freedman E."/>
                <person name="Gellesch M."/>
                <person name="Goldberg J."/>
                <person name="Griggs A."/>
                <person name="Gujja S."/>
                <person name="Heiman D."/>
                <person name="Hepburn T."/>
                <person name="Howarth C."/>
                <person name="Jen D."/>
                <person name="Larson L."/>
                <person name="Lewis B."/>
                <person name="Mehta T."/>
                <person name="Park D."/>
                <person name="Pearson M."/>
                <person name="Roberts A."/>
                <person name="Saif S."/>
                <person name="Shea T."/>
                <person name="Shenoy N."/>
                <person name="Sisk P."/>
                <person name="Stolte C."/>
                <person name="Sykes S."/>
                <person name="Walk T."/>
                <person name="White J."/>
                <person name="Yandava C."/>
                <person name="Nusbaum C."/>
                <person name="Galagan J."/>
                <person name="Birren B."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">T46</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="GG663496">
        <property type="protein sequence ID" value="EFD15261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242483">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="1">
        <location>
            <begin position="10"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EFD15261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000242483"/>
        </source>
    </evidence>
    <sequence length="192" mass="20306" checksum="2C7CAC3DD9C8869E" modified="2021-06-02" version="1">MDFTTTEAAQDLGGLVDTIVDAVCTPEHQRELDKLEQRFDRELWRKLIDAGILSSAAPESLGGDGFGVLEQVAVLVALGHQLAAVPYLESVVLAAGALARFGSPELQQGWGVSAVSGDRILTVALDGEMGEGPVQAAGTGHGYRLTGTRTQVGYGPVARRISGTSSETRFRCSRFPGAAGEPRGLRWTQGLR</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>